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Conserved domains on  [gi|208973226|ref|NP_001129169|]
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alpha-sarcoglycan isoform 2 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sarcoglycan_2 super family cl23856
Sarcoglycan alpha/epsilon; Sarcoglycans are a subcomplex of transmembrane proteins which are ...
 21-196 9.59e-32

Sarcoglycan alpha/epsilon; Sarcoglycans are a subcomplex of transmembrane proteins which are part of the dystrophin-glycoprotein complex. They are expressed in the skeletal, cardiac and smooth muscle. Although numerous studies have been conducted on the sarcoglycan subcomplex in skeletal and cardiac muscle, the manner of the distribution and localization of these proteins along the nonjunctional sarcolemma is not clear. This family contains alpha and epsilon members.


The actual alignment was detected with superfamily member pfam05510:

Pssm-ID: 461668  Cd Length: 410  Bit Score: 120.85  E-value: 9.59e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 208973226   21 TEAQQTTLHPLVGRVFVHTLDHETFLSLPEHVAVPpavhITYHAHLQGHPDLPRWLRYTQRSPHHPGFLYGSATPEDRGL 100
Cdd:pfam05510  17 KVHSDRTLQASVGELFTYKIEPELFNWTHEVISEQ----FTYRPSLEGYPDLPSWMRYMYSTEYHAGFLYGTPPAENAGK 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 208973226  101 QV-IEVTAYNRDSFDTtrQRLVLEIGDPEGPLLPYQAEFLVRSHDAEEVLPSTPASRFLSALG-GLWEP--GELQLLNVT 176
Cdd:pfam05510  93 PLiIEIIALNRQNYET--RRLIINMMVAHKFPTPNVIQMKIDNLNWVHMMDPGRVENLRNIFRkDLWPPsrEDLSIIFME 170

                         170       180
                  ....*....|....*....|
gi 208973226  177 SALDRGGRVPLPIEgRKEGL 196
Cdd:pfam05510 171 SAVNMGGRLPLRPQ-QREGV 189
 
Name Accession Description Interval E-value
Sarcoglycan_2 pfam05510
Sarcoglycan alpha/epsilon; Sarcoglycans are a subcomplex of transmembrane proteins which are ...
 21-196 9.59e-32

Sarcoglycan alpha/epsilon; Sarcoglycans are a subcomplex of transmembrane proteins which are part of the dystrophin-glycoprotein complex. They are expressed in the skeletal, cardiac and smooth muscle. Although numerous studies have been conducted on the sarcoglycan subcomplex in skeletal and cardiac muscle, the manner of the distribution and localization of these proteins along the nonjunctional sarcolemma is not clear. This family contains alpha and epsilon members.


Pssm-ID: 461668  Cd Length: 410  Bit Score: 120.85  E-value: 9.59e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 208973226   21 TEAQQTTLHPLVGRVFVHTLDHETFLSLPEHVAVPpavhITYHAHLQGHPDLPRWLRYTQRSPHHPGFLYGSATPEDRGL 100
Cdd:pfam05510  17 KVHSDRTLQASVGELFTYKIEPELFNWTHEVISEQ----FTYRPSLEGYPDLPSWMRYMYSTEYHAGFLYGTPPAENAGK 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 208973226  101 QV-IEVTAYNRDSFDTtrQRLVLEIGDPEGPLLPYQAEFLVRSHDAEEVLPSTPASRFLSALG-GLWEP--GELQLLNVT 176
Cdd:pfam05510  93 PLiIEIIALNRQNYET--RRLIINMMVAHKFPTPNVIQMKIDNLNWVHMMDPGRVENLRNIFRkDLWPPsrEDLSIIFME 170

                         170       180
                  ....*....|....*....|
gi 208973226  177 SALDRGGRVPLPIEgRKEGL 196
Cdd:pfam05510 171 SAVNMGGRLPLRPQ-QREGV 189
Dystroglycan_repeat cd11303
Cadherin-like repeat domain of alpha dystroglycan; Dystroglycan is a glycoprotein widely ...
 21-131 5.76e-18

Cadherin-like repeat domain of alpha dystroglycan; Dystroglycan is a glycoprotein widely distributed in skeletal muscle and other tissues; the pre-protein is cleaved into two subunits (alpha and beta) that form a complex which links the extracellular matrix to the cytoskeleton. Cadherin-like dystroglycan repeats are present in the extracellular alpha-dystroglycan subunit, which binds to the alpha-2-laminin G-domain in the basement membrane as part of the dystrophin-dystroglycan-complex (DGC). DGC has been shown to interact with other etxtracellular matrix components as well, such as perlecan and m-agrin, suggesting that the complex may play various different roles depending on the extracellular ligand.


Pssm-ID: 206636 [Multi-domain]  Cd Length: 99  Bit Score: 76.63  E-value: 5.76e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 208973226  21 TEAQQTTLHPLVGRVFVHTLDHETFLSLPEhvavppavhiTYHAHLQGHPDLPRWLRYTQRSphhpGFLYGSATPEDRGL 100
Cdd:cd11303    2 PLWGIPDLVAVVGRLFTYKIPPDTFSGNGD----------TYQVSEAGKDDLPSWLQFDSSS----RTLYGLPLSDDVGV 67

                         90       100       110
                 ....*....|....*....|....*....|..
gi 208973226 101 QVIEVTAYNRDS-FDTTRQRLVLEIGDPEGPL 131
Cdd:cd11303   68 HYISVTAEDKGSaGSQASDVFSIDVHPEPHPE 99
CADG smart00736
Dystroglycan-type cadherin-like domains; Cadherin-homologous domains present in metazoan ...
 29-128 3.13e-17

Dystroglycan-type cadherin-like domains; Cadherin-homologous domains present in metazoan dystroglycans and alpha/epsilon sarcoglycans, yeast Axl2p and in a very large protein from magnetotactic bacteria. Likely to bind calcium ions.


Pssm-ID: 214795 [Multi-domain]  Cd Length: 97  Bit Score: 74.69  E-value: 3.13e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 208973226    29 HPLVGRVFVHTLDHETFLSLPEHVAVPPAVHITYHAHLQGHPDLPRWLRYTQRSphhpGFLYGSATPEDRGLQVIEVTAY 108
Cdd:smart00736   1 ANAIGDQTATEGESFSYTIPSSTFTDADGDTLTYSATLSDGSALPSWLSFDSDT----GTLSGTPTNSDVGSLSLKVTAT 76

                           90       100
                   ....*....|....*....|
gi 208973226   109 NRDSfDTTRQRLVLEIGDPE 128
Cdd:smart00736  77 DSSG-ASASDTFTITVVNTN 95
 
Name Accession Description Interval E-value
Sarcoglycan_2 pfam05510
Sarcoglycan alpha/epsilon; Sarcoglycans are a subcomplex of transmembrane proteins which are ...
 21-196 9.59e-32

Sarcoglycan alpha/epsilon; Sarcoglycans are a subcomplex of transmembrane proteins which are part of the dystrophin-glycoprotein complex. They are expressed in the skeletal, cardiac and smooth muscle. Although numerous studies have been conducted on the sarcoglycan subcomplex in skeletal and cardiac muscle, the manner of the distribution and localization of these proteins along the nonjunctional sarcolemma is not clear. This family contains alpha and epsilon members.


Pssm-ID: 461668  Cd Length: 410  Bit Score: 120.85  E-value: 9.59e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 208973226   21 TEAQQTTLHPLVGRVFVHTLDHETFLSLPEHVAVPpavhITYHAHLQGHPDLPRWLRYTQRSPHHPGFLYGSATPEDRGL 100
Cdd:pfam05510  17 KVHSDRTLQASVGELFTYKIEPELFNWTHEVISEQ----FTYRPSLEGYPDLPSWMRYMYSTEYHAGFLYGTPPAENAGK 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 208973226  101 QV-IEVTAYNRDSFDTtrQRLVLEIGDPEGPLLPYQAEFLVRSHDAEEVLPSTPASRFLSALG-GLWEP--GELQLLNVT 176
Cdd:pfam05510  93 PLiIEIIALNRQNYET--RRLIINMMVAHKFPTPNVIQMKIDNLNWVHMMDPGRVENLRNIFRkDLWPPsrEDLSIIFME 170

                         170       180
                  ....*....|....*....|
gi 208973226  177 SALDRGGRVPLPIEgRKEGL 196
Cdd:pfam05510 171 SAVNMGGRLPLRPQ-QREGV 189
Dystroglycan_repeat cd11303
Cadherin-like repeat domain of alpha dystroglycan; Dystroglycan is a glycoprotein widely ...
 21-131 5.76e-18

Cadherin-like repeat domain of alpha dystroglycan; Dystroglycan is a glycoprotein widely distributed in skeletal muscle and other tissues; the pre-protein is cleaved into two subunits (alpha and beta) that form a complex which links the extracellular matrix to the cytoskeleton. Cadherin-like dystroglycan repeats are present in the extracellular alpha-dystroglycan subunit, which binds to the alpha-2-laminin G-domain in the basement membrane as part of the dystrophin-dystroglycan-complex (DGC). DGC has been shown to interact with other etxtracellular matrix components as well, such as perlecan and m-agrin, suggesting that the complex may play various different roles depending on the extracellular ligand.


Pssm-ID: 206636 [Multi-domain]  Cd Length: 99  Bit Score: 76.63  E-value: 5.76e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 208973226  21 TEAQQTTLHPLVGRVFVHTLDHETFLSLPEhvavppavhiTYHAHLQGHPDLPRWLRYTQRSphhpGFLYGSATPEDRGL 100
Cdd:cd11303    2 PLWGIPDLVAVVGRLFTYKIPPDTFSGNGD----------TYQVSEAGKDDLPSWLQFDSSS----RTLYGLPLSDDVGV 67

                         90       100       110
                 ....*....|....*....|....*....|..
gi 208973226 101 QVIEVTAYNRDS-FDTTRQRLVLEIGDPEGPL 131
Cdd:cd11303   68 HYISVTAEDKGSaGSQASDVFSIDVHPEPHPE 99
CADG smart00736
Dystroglycan-type cadherin-like domains; Cadherin-homologous domains present in metazoan ...
 29-128 3.13e-17

Dystroglycan-type cadherin-like domains; Cadherin-homologous domains present in metazoan dystroglycans and alpha/epsilon sarcoglycans, yeast Axl2p and in a very large protein from magnetotactic bacteria. Likely to bind calcium ions.


Pssm-ID: 214795 [Multi-domain]  Cd Length: 97  Bit Score: 74.69  E-value: 3.13e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 208973226    29 HPLVGRVFVHTLDHETFLSLPEHVAVPPAVHITYHAHLQGHPDLPRWLRYTQRSphhpGFLYGSATPEDRGLQVIEVTAY 108
Cdd:smart00736   1 ANAIGDQTATEGESFSYTIPSSTFTDADGDTLTYSATLSDGSALPSWLSFDSDT----GTLSGTPTNSDVGSLSLKVTAT 76

                           90       100
                   ....*....|....*....|
gi 208973226   109 NRDSfDTTRQRLVLEIGDPE 128
Cdd:smart00736  77 DSSG-ASASDTFTITVVNTN 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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