NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|207447703|ref|NP_001129057|]
View 

solute carrier family 2, facilitated glucose transporter member 5 isoform 2 [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 23-191 3.24e-102

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17432:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 452  Bit Score: 304.15  E-value: 3.24e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  23 IAAFGSSFQYGYNVAAVNSPALLMQQFYNETYYGRTGEFMEDFPLTLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGAL 102
Cdd:cd17432    4 AAAFGSSFQYGYNLSVVNSPTPYIQNFYNETWTERYGTPLEESTLTLLWSLTVSIFPLGGLFGSLLVGPLVIRLGRKGTL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703 103 LFNNIFSIVPAILMGCSRVATSFELIIISRLLVGICAGVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFGL 182
Cdd:cd17432   84 LLNNIFAIVAAILMGLSKIAKSFEMIIVGRFLVGINAGISLNVVPMYLGESAPKNLRGAVGLVPAIFITLGILLGQVLGL 163


                 ....*....
gi 207447703 183 RNLLANVDG 191
Cdd:cd17432  164 RELLGNEEG 172
 
Name Accession Description Interval E-value
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 23-191 3.24e-102

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 304.15  E-value: 3.24e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  23 IAAFGSSFQYGYNVAAVNSPALLMQQFYNETYYGRTGEFMEDFPLTLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGAL 102
Cdd:cd17432    4 AAAFGSSFQYGYNLSVVNSPTPYIQNFYNETWTERYGTPLEESTLTLLWSLTVSIFPLGGLFGSLLVGPLVIRLGRKGTL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703 103 LFNNIFSIVPAILMGCSRVATSFELIIISRLLVGICAGVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFGL 182
Cdd:cd17432   84 LLNNIFAIVAAILMGLSKIAKSFEMIIVGRFLVGINAGISLNVVPMYLGESAPKNLRGAVGLVPAIFITLGILLGQVLGL 163


                 ....*....
gi 207447703 183 RNLLANVDG 191
Cdd:cd17432  164 RELLGNEEG 172
Sugar_tr pfam00083
Sugar (and other) transporter;
23-194 7.53e-51

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 171.69  E-value: 7.53e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703   23 IAAFGSsFQYGYNVAAVNSPALLMQQFYNETYYGRTGEFMEdfpLTLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGAL 102
Cdd:pfam00083   4 VAALGG-FLFGYDTGVIGAFLTLIDFFKNFGLSKSVSSLAA---LSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  103 LFNNIFSIVPAILMGCSRVATSFELIIISRLLVGICAGVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFGL 182
Cdd:pfam00083  80 LIANVLFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGL 159

                         170
                  ....*....|..
gi 207447703  183 RNLLANVDGEFR 194
Cdd:pfam00083 160 GLNKTSNSDGWR 171
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 27-194 4.93e-45

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 157.12  E-value: 4.93e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703   27 GSSFQYGYNVAAVNSPALLMQQFYNETYYGRTGEFMEDFPLT---------LLWSVTVSMFPFGGFIGSLLVGPLVNKFG 97
Cdd:TIGR00879  20 GSTYWKVALLSLIAAIGGLMFGYDTGVIGGALALPAFEFKFTsansdsyssSLWGLVVSIFLVGGFIGALFAGWLSDRFG 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703   98 RKGALLFNNIFSIVPAILMGCSRVATSFELIIISRLLVGICAGVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVA 177
Cdd:TIGR00879 100 RKKSLLIIALLFVIGAILMGLAAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVA 179

                         170
                  ....*....|....*..
gi 207447703  178 QIFGLRNLLANVDGEFR 194
Cdd:TIGR00879 180 YGFGSGKVSLNNTLGWR 196
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
61-181 1.22e-11

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 63.45  E-value: 1.22e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  61 FMEDFPLTLLW-SVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICA 139
Cdd:COG2814   36 IAADLGASPAQaGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA---LAPSLWLLLAARFLQGLGA 112

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 207447703 140 GVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFG 181
Cdd:COG2814  113 GALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLG 154
xylE PRK10077
D-xylose transporter XylE; Provisional
 69-176 3.89e-09

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 56.24  E-value: 3.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  69 LLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAI------LMGCSRVATSFELII---ISRLLVGICA 139
Cdd:PRK10077  55 SLLGFCVASALIGCIIGGALGGYCSNRFGRRDSLKIAAVLFFISALgsawpeFGFTSIGPDNTGYVPefvIYRIIGGIGV 134

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 207447703 140 GVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILV 176
Cdd:PRK10077 135 GLASMLSPMYIAEIAPAHIRGKLVSFNQFAIIFGQLV 171
 
Name Accession Description Interval E-value
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 23-191 3.24e-102

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 304.15  E-value: 3.24e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  23 IAAFGSSFQYGYNVAAVNSPALLMQQFYNETYYGRTGEFMEDFPLTLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGAL 102
Cdd:cd17432    4 AAAFGSSFQYGYNLSVVNSPTPYIQNFYNETWTERYGTPLEESTLTLLWSLTVSIFPLGGLFGSLLVGPLVIRLGRKGTL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703 103 LFNNIFSIVPAILMGCSRVATSFELIIISRLLVGICAGVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFGL 182
Cdd:cd17432   84 LLNNIFAIVAAILMGLSKIAKSFEMIIVGRFLVGINAGISLNVVPMYLGESAPKNLRGAVGLVPAIFITLGILLGQVLGL 163


                 ....*....
gi 207447703 183 RNLLANVDG 191
Cdd:cd17432  164 RELLGNEEG 172
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 23-190 1.50e-63

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 204.42  E-value: 1.50e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  23 IAAFGSSFQYGYNVAAVNSPALLMQQFYNETYYGRTGEFMEDFPLTLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGAL 102
Cdd:cd17357    3 IVAFGGSFQFGYNIGVVNAPQEVFKEFINDTLVDRYGLNLSDSELDLLWSLIVSIFFIGGAIGSFISAFLANRFGRKNGL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703 103 LFNNIFSIVPAILMGCSRVATSFELIIISRLLVGICAGVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFGL 182
Cdd:cd17357   83 LISNALLVVSSLLMFLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEISPSELRGALGSLTQIGVTLGILLGQVFGL 162


                 ....*...
gi 207447703 183 RNLLANVD 190
Cdd:cd17357  163 PSVLGTET 170
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 29-191 2.43e-57

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 188.31  E-value: 2.43e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  29 SFQYGYNVAAVNSPALLMQQFYNETYYGRTGEFMEDFPLTLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIF 108
Cdd:cd17431   10 SLQFGYNTGVINAPQKVIEEFYNKTLGDRYGEPISPETLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLYNNLL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703 109 SIVPAILMGCSRVATSFELIIISRLLVGICAGVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFGLRNLLAN 188
Cdd:cd17431   90 AFAGAALMGLSKLAKSYEMLILGRFIIGLYCGLTTGLVPMYIGEISPTALRGALGTLHQLGIVVGILISQIFGLEFILGT 169


                 ...
gi 207447703 189 VDG 191
Cdd:cd17431  170 EEL 172
Sugar_tr pfam00083
Sugar (and other) transporter;
23-194 7.53e-51

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 171.69  E-value: 7.53e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703   23 IAAFGSsFQYGYNVAAVNSPALLMQQFYNETYYGRTGEFMEdfpLTLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGAL 102
Cdd:pfam00083   4 VAALGG-FLFGYDTGVIGAFLTLIDFFKNFGLSKSVSSLAA---LSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  103 LFNNIFSIVPAILMGCSRVATSFELIIISRLLVGICAGVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFGL 182
Cdd:pfam00083  80 LIANVLFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGL 159

                         170
                  ....*....|..
gi 207447703  183 RNLLANVDGEFR 194
Cdd:pfam00083 160 GLNKTSNSDGWR 171
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 27-194 4.93e-45

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 157.12  E-value: 4.93e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703   27 GSSFQYGYNVAAVNSPALLMQQFYNETYYGRTGEFMEDFPLT---------LLWSVTVSMFPFGGFIGSLLVGPLVNKFG 97
Cdd:TIGR00879  20 GSTYWKVALLSLIAAIGGLMFGYDTGVIGGALALPAFEFKFTsansdsyssSLWGLVVSIFLVGGFIGALFAGWLSDRFG 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703   98 RKGALLFNNIFSIVPAILMGCSRVATSFELIIISRLLVGICAGVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVA 177
Cdd:TIGR00879 100 RKKSLLIIALLFVIGAILMGLAAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVA 179

                         170
                  ....*....|....*..
gi 207447703  178 QIFGLRNLLANVDGEFR 194
Cdd:TIGR00879 180 YGFGSGKVSLNNTLGWR 196
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 23-182 1.39e-35

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 129.62  E-value: 1.39e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  23 IAAFGSsFQYGYNVAAVNSPALLMQQFYNETYygrtgefmedfpLTLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGAL 102
Cdd:cd17315    1 VAALGG-LLFGYDLGVINGALLYIAKDLGFGL------------STSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSL 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703 103 LFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICAGVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFGL 182
Cdd:cd17315   68 LIAAVLYVIGALLSA---LAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGL 144
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 64-182 1.30e-27

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 109.20  E-value: 1.30e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  64 DFPLTLL-WSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSRvatSFELIIISRLLVGICAGVS 142
Cdd:cd17358   35 SLPLTVAqFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAK---DVWMLYLGRFLAGFGGGAA 111

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 207447703 143 SNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFGL 182
Cdd:cd17358  112 SVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGS 151
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 23-189 2.32e-23

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 96.94  E-value: 2.32e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  23 IAAFGSSFQyGYNVAAVNSpaLLMQQFYNEtYYGRTGEFmeDFPLTLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGAL 102
Cdd:cd17356    5 FVSLGGFLF-GYDTGSISG--ILNMKSFQK-YFADNTGT--YYPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSI 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703 103 LFNNIFSIVPAILMGCSrvATSFELIIISRLLVGICAGVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQI--F 180
Cdd:cd17356   79 QIGCVIYIIGAIIQVAA--IGKWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCinY 156


                 ....*....
gi 207447703 181 GLRNLLANV 189
Cdd:cd17356  157 GTHKLDGSA 165
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 30-182 1.07e-21

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 91.95  E-value: 1.07e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  30 FQYGYNVAAVNSPALLMqqfynetyygrtGEFMEDFPLTLLW-SVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIF 108
Cdd:cd17360    7 FLFGYDTGVISGALLYI------------KDDLGEVVLSTGWqELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADAL 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 207447703 109 SIVPAILMGcsrVATSFELIIISRLLVGICAGVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFGL 182
Cdd:cd17360   75 FTIGAIVMA---AAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVING 145
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 23-180 9.92e-21

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 89.55  E-value: 9.92e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  23 IAAFGSsFQYGYNVAAVNSPALLMQQFYNetyygrTGEFMEDFpltllwsvTVSMFPFGGFIGSLLVGPLVNKFGRKGAL 102
Cdd:cd17359    5 VAALGG-LLFGYDTGVINGALPFLQTDFN------LTPFLEGL--------VVSSALLGAAIGALFAGRLADRFGRRKTL 69

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 207447703 103 LFNNIFSIVPAIlmGCSrVATSFELIIISRLLVGICAGVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIF 180
Cdd:cd17359   70 LISAVLFFISAL--GSA-FSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIV 144
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
 69-188 9.53e-17

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 78.45  E-value: 9.53e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  69 LLWSVTVSMFpFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICAGVSSNVVPM 148
Cdd:cd17361   52 LLQLFTSSLY-LAGLVASLLASYVTRKWGRKPSMLIGGVLFLVGAALNA---AAQNIAMLIVGRILLGFGVGFGNQAVPL 127

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 207447703 149 YLGELAPKNLRGALGVVPQLFITVGILVAQI--FGLRNLLAN 188
Cdd:cd17361  128 YLSEMAPAKLRGALNIGFQLAITIGILIANLinYGTSKIKPN 169
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 75-194 1.55e-13

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 68.92  E-value: 1.55e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  75 VSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCsrvATSFELIIISRLLVGICAGVSSNVVPMYLGELA 154
Cdd:cd17362   45 VSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGL---APSYPVLLVGRLIYGVGIGLAMHAAPVYIAETS 121

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 207447703 155 PKNLRGALGVVPQLFITVGILVAqiFGLRNLLANVDGEFR 194
Cdd:cd17362  122 PSHIRGLLVSLKELFIVLGILLG--YVSGYAFADVVGGWR 159
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 76-182 3.86e-12

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 65.28  E-value: 3.86e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  76 SMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVP-AILMGcsrvATSFELIIISRLLVGICAGVSSNVVPMYLGELA 154
Cdd:cd17433   48 SVVTLGAAAGGVLGGWIVDRAGRKLSLMLCSVPFIAGfTVITA----AQNVWMLYVGRLLTGLASGVTSLVVPVYISEIA 123

                         90       100
                 ....*....|....*....|....*...
gi 207447703 155 PKNLRGALGVVPQLFITVGILVAQIFGL 182
Cdd:cd17433  124 HPRVRGTLGSCVQLMVVIGIMGAYLAGL 151
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
 84-179 1.07e-11

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 63.57  E-value: 1.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  84 IGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICAGVSSNVVPMYLGELAPKNLRGALG 163
Cdd:cd17437   47 VGSLAAGRTSDWIGRRYTIALAALIFFVGALLMG---VAPNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLT 123

                         90
                 ....*....|....*.
gi 207447703 164 VVPQLFITVGILVAQI 179
Cdd:cd17437  124 SFPEIFINIGILLGYV 139
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
61-181 1.22e-11

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 63.45  E-value: 1.22e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  61 FMEDFPLTLLW-SVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICA 139
Cdd:COG2814   36 IAADLGASPAQaGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA---LAPSLWLLLAARFLQGLGA 112

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 207447703 140 GVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFG 181
Cdd:COG2814  113 GALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLG 154
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 66-181 1.25e-11

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 62.91  E-value: 1.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  66 PLTLLWSVTVSMFPFGgfIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICAGVSSNV 145
Cdd:COG0477   48 SAQLGWIVSAYLLGRA--IGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCG---LAPSPELLIAARALQGIGAGGLMPG 122

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 207447703 146 VPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFG 181
Cdd:COG0477  123 ALALIAELFPARERGRALGLWGAAIGLGLALGPLLG 158
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 73-189 2.31e-11

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 62.51  E-value: 2.31e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  73 VTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSrvaTSFELIIISRLLVGICAGVSSNVVPMYLGE 152
Cdd:cd17435   40 MVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCS---VSYTVLIVGRIAIGVSISLSSIATCVYIAE 116

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 207447703 153 LAPKNLRGALGVVPQLFITVGILVAqiFGLRNLLANV 189
Cdd:cd17435  117 IAPQHRRGLLVSLNELMIVIGILLA--YISNYAFANV 151
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 76-182 8.19e-11

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 61.00  E-value: 8.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  76 SMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCsrvATSFELIIISRLLVGICAGVSSNVVPMYLGELAP 155
Cdd:cd17434   48 SVFTLGAAAGGLSAMFLNDRLGRKLSIMFSAVPSALGYLLMGS---AQGIWMLLLGRFLTGFAGGITAASIPVYVSEISH 124

                         90       100
                 ....*....|....*....|....*..
gi 207447703 156 KNLRGALGVVPQLFITVGILVAQIFGL 182
Cdd:cd17434  125 PGVRGALGACPQIMAVFGSLALYALGL 151
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 64-177 1.54e-10

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 60.31  E-value: 1.54e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  64 DFPLTLLWSVTVSMFPF-GGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSrvaTSFELIIISRLLVGICAGVS 142
Cdd:cd17316   30 SLGLSLLQTGLLFAAGFlGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLL---PTPILLLVLRFLQGIGIGGE 106

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 207447703 143 SNVVPMYLGELAPKNLRGALGVVPQLFITVGILVA 177
Cdd:cd17316  107 YPGASTYVAEFAPSKRRGFALGLLQSGWALGALLA 141
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 61-182 1.72e-10

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 60.13  E-value: 1.72e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  61 FMEDFPLTL-LWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICA 139
Cdd:cd06174   22 LLQSFGLSAsQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA---FAPSFWLLLLGRFLLGLGS 98

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 207447703 140 GVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFGL 182
Cdd:cd06174   99 GLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGG 141
xylE PRK10077
D-xylose transporter XylE; Provisional
 69-176 3.89e-09

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 56.24  E-value: 3.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  69 LLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAI------LMGCSRVATSFELII---ISRLLVGICA 139
Cdd:PRK10077  55 SLLGFCVASALIGCIIGGALGGYCSNRFGRRDSLKIAAVLFFISALgsawpeFGFTSIGPDNTGYVPefvIYRIIGGIGV 134

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 207447703 140 GVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILV 176
Cdd:PRK10077 135 GLASMLSPMYIAEIAPAHIRGKLVSFNQFAIIFGQLV 171
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 74-181 5.47e-09

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 55.63  E-value: 5.47e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  74 TVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICAGVSSNVVPMYLGEL 153
Cdd:cd17324   39 LVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAA---LAPSFALLLLARALAGLAHGGFWAIAAAYAADL 115

                         90       100
                 ....*....|....*....|....*....
gi 207447703 154 APKNLRG-ALGVVpQLFITVGILVAQIFG 181
Cdd:cd17324  116 VPPEKRGrAIGLV-FSGLTLGLVLGRPLG 143
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 61-181 2.28e-08

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 53.73  E-value: 2.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  61 FMEDFPLT-LLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICA 139
Cdd:cd17325   22 YAESLGASvAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA---FATSYWQLLLARFLQGLAS 98

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 207447703 140 GVSSNVVPMYLGELAPKNLRG-ALGVVpQLFITVGILVAQIFG 181
Cdd:cd17325   99 AAVWPAAMALIADIAPPEERGrAMGIF-SSAIGLGFLIGPLLG 140
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 72-176 1.12e-07

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 51.43  E-value: 1.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  72 SVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGI-CAGVSsnVVPMYL 150
Cdd:cd17317   28 ALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSA---FSPSYELFLVLRFLVGVtSAGIF--TVGFVL 102

                         90       100
                 ....*....|....*....|....*..
gi 207447703 151 G-ELAPKNLRGALGVVPQLFITVGILV 176
Cdd:cd17317  103 GmEIVGPKYRSFVGILFGLFWALGYML 129
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
72-181 2.87e-07

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 50.65  E-value: 2.87e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  72 SVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICAGVSSNVVPMYLG 151
Cdd:COG2223   43 GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLA---LAVSYWLLLLLGLLLGIGGGGSFAVGIALVS 119

                         90       100       110
                 ....*....|....*....|....*....|.
gi 207447703 152 ELAPKNLRG-ALGVVpQLFITVGILVAQIFG 181
Cdd:COG2223  120 KWFPPDRRGlALGLA-AGGGNLGAAVAAFLA 149
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
60-181 2.31e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 47.56  E-value: 2.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  60 EFMEDFPLTLL-WSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGIC 138
Cdd:COG2271   35 PLQADLGLSAAqLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFG---FATSFWQLLLLRFLLGLG 111

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 207447703 139 AGVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFG 181
Cdd:COG2271  112 EAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLL 154
MFS_1 pfam07690
Major Facilitator Superfamily;
75-181 2.42e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 47.80  E-value: 2.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703   75 VSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICAGVSSNVVPMYLGELA 154
Cdd:pfam07690  38 LTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL---FASSLWLLLVLRVLQGLGAGALFPAALALIADWF 114

                          90       100
                  ....*....|....*....|....*...
gi 207447703  155 PKNLRG-ALGVVpQLFITVGILVAQIFG 181
Cdd:pfam07690 115 PPEERGrALGLV-SAGFGLGAALGPLLG 141
MFS_GLUT10_Class3 cd17436
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 75-177 4.02e-06

Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340994 [Multi-domain]  Cd Length: 376  Bit Score: 47.10  E-value: 4.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  75 VSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICAGVSSNVVPMYLGELA 154
Cdd:cd17436   42 VSALLIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGSLILT---LAGSFFWLVIGRAVVGFAISVSSMACCIYVSEMV 118

                         90       100
                 ....*....|....*....|...
gi 207447703 155 PKNLRGALGVVPQLFITVGILVA 177
Cdd:cd17436  119 TPHQRGLLVSLYEAGITVGILIS 141
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 74-176 4.43e-06

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 46.93  E-value: 4.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703   74 TVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNnifSIVPAILMGCSRVATSFELIIISRLLVGI-CAGVSSNVVPMYLgE 152
Cdd:TIGR00898 132 TQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLS---TLVTAVSGVLTAFSPNYTVFLVFRLLVGMgIGGIWVQAVVLNT-E 207

                          90       100
                  ....*....|....*....|....
gi 207447703  153 LAPKNLRGALGVVPQLFITVGILV 176
Cdd:TIGR00898 208 FLPKKQRAIVGTLIQVFFSLGLVL 231
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 80-176 4.79e-06

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 46.58  E-value: 4.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  80 FGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICAGVSSNVVPMYLGELAPKNLR 159
Cdd:cd17379   44 LGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMA---FSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYR 120

                         90
                 ....*....|....*..
gi 207447703 160 GALGVVPQLFITVGILV 176
Cdd:cd17379  121 RTVGIVYQMFFTLGLLI 137
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 72-193 5.89e-06

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 46.31  E-value: 5.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  72 SVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICAGVSSNVVPMYLG 151
Cdd:cd17377   42 SLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNA---LAPSYEFFAVSRFLVGVMNGGMSLVAFVLLN 118

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 207447703 152 ELAPKNLRGALGVVPQLFITVGILVAQIFGL-----RNL--LANVDGEF 193
Cdd:cd17377  119 ECVGKSYWALAGSLGGLFFAVGIAQYALLGYfirswRTLavVVNLQGTL 167
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
75-182 9.58e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 46.02  E-value: 9.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  75 VSMFPFGGFIGSLLVGPLVNKFGRKGALLFNnIFSIVPAILMGCSRVATSFELIIISRLLVGICAGVSSNVVPMYLGELA 154
Cdd:COG2271  222 LSLPFLAGIVGSLLGGWLSDRLGRRRKLVLA-IGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELF 300

                         90       100
                 ....*....|....*....|....*....
gi 207447703 155 PKNLRG-ALGVVPQLFITVGILVAQIFGL 182
Cdd:COG2271  301 PKKARGtASGLVNTFGFLGGALGPLLVGY 329
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 75-182 1.07e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 45.66  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  75 VSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICAGVSSNVVPMYLGELA 154
Cdd:cd17489   37 VGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL---LATSVALLLVLRLIHGIGWGAFTTAAATLVADII 113

                         90       100
                 ....*....|....*....|....*....
gi 207447703 155 PKNLRG-ALGVVpQLFITVGILVAQIFGL 182
Cdd:cd17489  114 PPSRRGeGIGYY-GLATTLAMALGPALGL 141
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 68-180 1.08e-05

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 45.63  E-value: 1.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  68 TLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLfnnIFSIVPAILMGCSRVATSFELIIISRLLVGICAGVSSNVVP 147
Cdd:cd17477   30 TALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFA---AGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSE 106

                         90       100       110
                 ....*....|....*....|....*....|...
gi 207447703 148 MYLGELAPKNLRGALGVVPQLFITVGILVAQIF 180
Cdd:cd17477  107 SWLNALATNENRGRVLGLYSTVLGLGFALGPLL 139
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 59-177 1.32e-05

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 45.37  E-value: 1.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  59 GEFMEDFPLTLLWS-VTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGI 137
Cdd:cd17371   23 PALIAEFGLDEAEAgLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCG---FAQNYWQLLILRALAGL 99

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 207447703 138 CAGVSSNVVPMYLGELAPKNLRG-ALGVVpQLFITVGILVA 177
Cdd:cd17371  100 GFGGEWAAGAALMAEYVPARHRGkALGYV-QSGWAVGWLLA 139
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
76-174 1.63e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 44.96  E-value: 1.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  76 SMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICAGVSSNVVPMYLGELAP 155
Cdd:COG2814  250 ALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLA---LAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAP 326

                         90
                 ....*....|....*....
gi 207447703 156 KNLRGALGVVPQLFITVGI 174
Cdd:COG2814  327 PEARGRASGLYNSAFFLGG 345
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
61-181 2.19e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 44.84  E-value: 2.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  61 FMEDFPLTLLWSVTV-SMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICA 139
Cdd:COG0738   34 LKDAFGLSDAQAGLLlFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFA---LAPSYPLLLLALFLLGLGL 110

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 207447703 140 GVSSNVVPMYLGELAPKNLRGALGVVpQLFITVGILVAQIFG 181
Cdd:COG0738  111 GLLDVAANPYVAALGPETAASRLNLL-HAFFSLGALLGPLLG 151
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 84-180 3.30e-05

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 44.54  E-value: 3.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  84 IGSLLVGPLVNKFGRKGALLFNNIFSIVPAILmgCSRvATSFELIIISRLLVGICAGVSSNVVPMyLGELAPKNLR---- 159
Cdd:cd06179   47 VLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIV--AGT-AKSVNMLIGGQALIGIGAGTQGLGAAV-ASELVPNKYRglvq 122

                         90       100
                 ....*....|....*....|.
gi 207447703 160 GALGVVPQLFITVGILVAQIF 180
Cdd:cd06179  123 GVVNLVASPGSALGPLIAGAL 143
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 54-181 3.78e-05

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 44.10  E-value: 3.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  54 YYGRTGEFMEDFPLTL-LWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSRvatSFELIIISR 132
Cdd:cd17323   18 YSPALPQIAEDFHVSEeVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAP---NIAMLIILR 94

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 207447703 133 LLVGICAGVSSNVVPMYLGELAPKNLRG-ALGVVpqlfiTVGILVAQIFG 181
Cdd:cd17323   95 FLQGFFGSSPLAIGAGTIADLFTPEERGkAMGVY-----SLGPLLGPALG 139
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
75-182 4.90e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 43.72  E-value: 4.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  75 VSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMgcSRVATSFELIIISRLLVGICAGVSSNVVPMYLGELA 154
Cdd:COG2223  247 AALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLL--ALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIF 324

                         90       100
                 ....*....|....*....|....*....
gi 207447703 155 PKNLRGA-LGVVPQLFITVGILVAQIFGL 182
Cdd:COG2223  325 PTKNAGAvYGLVGAAGGLGGFLGPLLFGA 353
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 75-160 5.26e-05

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 43.74  E-value: 5.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  75 VSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSRVATSFeLIIISRLLVGICAGVSSNVVPMYLGELA 154
Cdd:cd17316  219 LLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPT-LLLLLLFILSFFVGGVWGALYAYLAELF 297


                 ....*.
gi 207447703 155 PKNLRG 160
Cdd:cd17316  298 PTEVRA 303
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
 84-182 9.25e-05

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 43.05  E-value: 9.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  84 IGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSRV-----ATSFELIIISRLLVGICAGVSSNVVPMYLGELAPKNL 158
Cdd:cd17367   55 IGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTyatigIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGR 134

                         90       100
                 ....*....|....*....|....
gi 207447703 159 RGALGVVPQLFITVGILVAQIFGL 182
Cdd:cd17367  135 RGFYSSFQYVTLIGGQLLALGVLL 158
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 70-184 1.13e-04

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 42.66  E-value: 1.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  70 LWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLfnniFSIVPAILMG-CSRVATSFELIIISRLLVGIC-AGVSSNVVP 147
Cdd:cd17374   36 LKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILL----LSLLQLAIFGtCAAFAPTFPVYCVLRFLAGFAvSGISINTLI 111

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 207447703 148 MYLgELAPKNLRGALGVVPQLFITVG--ILVAQIFGLRN 184
Cdd:cd17374  112 LGT-EWTTPRHRALAITLTSCFFSIGqmLLAGLAYAIRD 149
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 42-177 1.16e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 42.54  E-value: 1.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  42 PALLMQQFYNETYYGrtgefmedfpltllwsVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMgcsrV 121
Cdd:cd17478  219 PFYLVQRGYSLVFAG----------------LLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLF----L 278

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 207447703 122 ATSFELIIISRLLVGICAGVSSNVVPMYLGELAPKNLRGALGVVPQL-FITVGILVA 177
Cdd:cd17478  279 LTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNVGLASGLMMGLsFGLGGIGAP 335
MFS_1 pfam07690
Major Facilitator Superfamily;
68-177 4.08e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 40.86  E-value: 4.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703   68 TLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSRVATSFELIIISRLLVGICAGVSSNVVP 147
Cdd:pfam07690 234 ALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALN 313

                          90       100       110
                  ....*....|....*....|....*....|
gi 207447703  148 MYLGELAPKNLRGALGVVPQLFITVGILVA 177
Cdd:pfam07690 314 ALVSDLAPKEERGTASGLYNTAGSLGGALG 343
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 69-169 5.12e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 40.64  E-value: 5.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  69 LLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICAGVSSnVVPM 148
Cdd:cd17330   34 YYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLG---LSRNLWLLFLARFLDGLTGGNVS-VAQA 109

                         90       100
                 ....*....|....*....|..
gi 207447703 149 YLGEL-APKNLRGALGVVPQLF 169
Cdd:cd17330  110 YIADItDEEERAKAFGIISAAF 131
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 84-141 7.12e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 40.25  E-value: 7.12e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 207447703  84 IGSLLVGPLVNKFGRKGALlfnnIFSIVPAILMGCSRV-ATSFELIIISRLLVGICAGV 141
Cdd:cd17473   50 LFAPLAGWLADRFGRKRLL----IAGLLLYGIGGVAGLfLDSLYALLASRALLGIGVAG 104
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 80-140 7.23e-04

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 40.34  E-value: 7.23e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 207447703  80 FGGFIGSL----------LVGPLVNKFGRKGALLFNNIFSIVPAILMGCSRvatSFELIIISRLLVGICAG 140
Cdd:cd17389   65 FGGLIGSLfsllqflsspITGAASDVYGRKPVLLLTMIGLAISYALWAVSR---SFTIFLLSRIVGGISKG 132
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 74-183 1.07e-03

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 39.48  E-value: 1.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  74 TVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICAGVSSNVVP-----M 148
Cdd:cd17320   39 TLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCA---LASSIEQLLIARFLQGLGAAAGSVVARaivrdL 115

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 207447703 149 YLGELAPK---NLRGALGVVPQLFITVGILVAQIFGLR 183
Cdd:cd17320  116 YSGAELAKifsLLMMILAIAPALAPLLGGLLLLFFGWR 153
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 80-181 1.12e-03

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 39.65  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703   80 FGGFIGSLLVGPLVNKFGRKGALLfnnIFSIVPAILMGCSRVATSFELIIISRLLVGICAGVSSNVVPMYLGELAPKNLR 159
Cdd:TIGR00895  63 IGMAFGALFFGPLADRIGRRRVLL---WSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFR 139

                          90       100
                  ....*....|....*....|..
gi 207447703  160 GALGVVPQLFITVGILVAQIFG 181
Cdd:TIGR00895 140 GTAVGLMFCGYPIGAAVGGFLA 161
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 70-181 1.28e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 39.52  E-value: 1.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  70 LWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLfnnIFSIVPAILMGCSRVATSFELIIISRLLVGICAGVSSNVVPMY 149
Cdd:cd06173  245 GYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLL---IGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTL 321

                         90       100       110
                 ....*....|....*....|....*....|..
gi 207447703 150 LGELAPKNLRGALGVVPQLFITVGILVAQIFG 181
Cdd:cd06173  322 LQLRVPDELRGRVFSVYNALNSGAMPLGALLA 353
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 80-173 1.36e-03

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 39.11  E-value: 1.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  80 FGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSRVATSFELIiisRLLVGICAGVSSNVVPMYLGELAPKNLR 159
Cdd:cd17365   45 FGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALL---RFLTGLGLGAAMPNAITLVSEYAPARRR 121

                         90
                 ....*....|....
gi 207447703 160 GALGVVPQLFITVG 173
Cdd:cd17365  122 SLAVTLMFCGYPLG 135
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
 80-182 1.55e-03

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 39.18  E-value: 1.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  80 FGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCS---RVATSFELIIISRLLVGICAGVSSNVVPMYLGELAPK 156
Cdd:cd17364   50 VGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSpgsTPLGVMGWLIFFRFLLGIGIGGDYPLSATIMSEYANK 129

                         90       100
                 ....*....|....*....|....*.
gi 207447703 157 NLRGALGVVPQLFITVGILVAQIFGL 182
Cdd:cd17364  130 KRRGALIAAVFAMQGFGILAGAIVTL 155
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 68-181 1.86e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 38.71  E-value: 1.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  68 TLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICAGVSSNVVP 147
Cdd:cd17325  234 PAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLP---LATSFWLLLLLLALLGLGLGLVFPATL 310

                         90       100       110
                 ....*....|....*....|....*....|....
gi 207447703 148 MYLGELAPKNLRGALGVVPQLFITVGILVAQIFG 181
Cdd:cd17325  311 ALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLG 344
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 68-164 2.39e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 38.69  E-value: 2.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  68 TLLWSVTVSMFPFGGFIgsLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGICAGVSSNVVP 147
Cdd:cd17321   32 QLQWVVNAYLLAFAALL--LLAGRLGDRFGRKRVFLIGLALFGLASLLCA---LAPSLAFLIAARALQGIGAAAIMPASL 106

                         90
                 ....*....|....*...
gi 207447703 148 MYLGELAPKNLRG-ALGV 164
Cdd:cd17321  107 ALIAATFPGERRGrALGL 124
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 71-181 6.90e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 37.16  E-value: 6.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  71 WSVTVSMFPFGGFIgsLLVGPLVNKFGRKGALLFNNIFSIVPAILMGcsrVATSFELIIISRLLVGI-CAGVSSNVVPMy 149
Cdd:cd17474   38 LLITAFTLPAAVLM--PVAGVLADRFGRKKVLLPGLLLFGIGGLLCG---LSDSFALLLAGRALQGIgAAGLGPLALTL- 111

                         90       100       110
                 ....*....|....*....|....*....|...
gi 207447703 150 LGELAPKNLRG-ALGVVpQLFITVGILVAQIFG 181
Cdd:cd17474  112 IGDLFEGGERAkAMGLY-EAALGLGIAVGPLLG 143
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
70-155 9.17e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 36.80  E-value: 9.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207447703  70 LWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSRvATSFELIIISRLLVGICAGVSSNVVPMY 149
Cdd:COG2211  265 LVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLG-PGNLWLLLVLAALAGIGLGAILVLPWAM 343


                 ....*.
gi 207447703 150 LGELAP 155
Cdd:COG2211  344 LADVVD 349
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 83-159 9.77e-03

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 36.82  E-value: 9.77e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 207447703  83 FIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSrvaTSFELIIISRLLVGICAGvSSNVVPMYLGELAPKNLR 159
Cdd:cd17390   45 LFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFS---TSLALLFLSRIPLGIFKH-TQSLCKAYLSDLVSEQER 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH