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Conserved domains on  [gi|4501995|ref|NP_001129|]
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agouti-related protein precursor [Homo sapiens]

Protein Classification

Agouti domain-containing protein( domain architecture ID 10655107)

Agouti domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Agouti smart00792
Agouti protein; The agouti protein regulates pigmentation in the mouse hair follicle producing ...
 1-122 2.97e-41

Agouti protein; The agouti protein regulates pigmentation in the mouse hair follicle producing a black hair with a subapical yellow band. A highly homologous protein agouti signal protein (ASIP) is present in humans and is expressed at highest levels in adipose tissue where it may play a role in energy homeostasis and possibly human pigmentation.


:

Pssm-ID: 197876  Cd Length: 124  Bit Score: 133.09  E-value: 2.97e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4501995       1 MLTAAVLSCALLLALPATRGAQMGLAPMEGIR---RPDQALLPELPGLGLRAPLKKTTAEQAEEDLLQ--EAQALAEVLD 75
Cdd:smart00792   1 MLLATLLGCLLLLTVHSHLGAEEGLEDARGARsnsSLNQADFPSVSIVGLNKKPKKISAEEAEKKLLQkkEKKALTNVLR 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 4501995      76 LqdrEPRSSRRCVRLHESCLGQQVPCCDPCATCYCRFFNAFCYCRKL 122
Cdd:smart00792  81 P---EPRSPRRCVRLRDSCKGPQPPCCDPCATCYCRFFNAFCYCRKL 124
 
Name Accession Description Interval E-value
Agouti smart00792
Agouti protein; The agouti protein regulates pigmentation in the mouse hair follicle producing ...
 1-122 2.97e-41

Agouti protein; The agouti protein regulates pigmentation in the mouse hair follicle producing a black hair with a subapical yellow band. A highly homologous protein agouti signal protein (ASIP) is present in humans and is expressed at highest levels in adipose tissue where it may play a role in energy homeostasis and possibly human pigmentation.


Pssm-ID: 197876  Cd Length: 124  Bit Score: 133.09  E-value: 2.97e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4501995       1 MLTAAVLSCALLLALPATRGAQMGLAPMEGIR---RPDQALLPELPGLGLRAPLKKTTAEQAEEDLLQ--EAQALAEVLD 75
Cdd:smart00792   1 MLLATLLGCLLLLTVHSHLGAEEGLEDARGARsnsSLNQADFPSVSIVGLNKKPKKISAEEAEKKLLQkkEKKALTNVLR 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 4501995      76 LqdrEPRSSRRCVRLHESCLGQQVPCCDPCATCYCRFFNAFCYCRKL 122
Cdd:smart00792  81 P---EPRSPRRCVRLRDSCKGPQPPCCDPCATCYCRFFNAFCYCRKL 124
Agouti pfam05039
Agouti protein; The agouti protein regulates pigmentation in the mouse hair follicle producing ...
 80-120 4.39e-16

Agouti protein; The agouti protein regulates pigmentation in the mouse hair follicle producing a black hair with a subapical yellow band. A highly homologous protein agouti signal protein (ASIP)is present in humans and is expressed at highest levels in adipose tissue where it may play a role in energy homeostasis and possibly human pigmentation.


Pssm-ID: 428273  Cd Length: 43  Bit Score: 66.69  E-value: 4.39e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 4501995     80 EPRSSRRCVRLHESCLGQQVPCCDPCATCYCRFFNAFCYCR 120
Cdd:pfam05039   2 RPPPPRRCVRLRESCKPHQVPCCDPCATCYCRFFRAFCYCR 42
 
Name Accession Description Interval E-value
Agouti smart00792
Agouti protein; The agouti protein regulates pigmentation in the mouse hair follicle producing ...
 1-122 2.97e-41

Agouti protein; The agouti protein regulates pigmentation in the mouse hair follicle producing a black hair with a subapical yellow band. A highly homologous protein agouti signal protein (ASIP) is present in humans and is expressed at highest levels in adipose tissue where it may play a role in energy homeostasis and possibly human pigmentation.


Pssm-ID: 197876  Cd Length: 124  Bit Score: 133.09  E-value: 2.97e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4501995       1 MLTAAVLSCALLLALPATRGAQMGLAPMEGIR---RPDQALLPELPGLGLRAPLKKTTAEQAEEDLLQ--EAQALAEVLD 75
Cdd:smart00792   1 MLLATLLGCLLLLTVHSHLGAEEGLEDARGARsnsSLNQADFPSVSIVGLNKKPKKISAEEAEKKLLQkkEKKALTNVLR 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 4501995      76 LqdrEPRSSRRCVRLHESCLGQQVPCCDPCATCYCRFFNAFCYCRKL 122
Cdd:smart00792  81 P---EPRSPRRCVRLRDSCKGPQPPCCDPCATCYCRFFNAFCYCRKL 124
Agouti pfam05039
Agouti protein; The agouti protein regulates pigmentation in the mouse hair follicle producing ...
 80-120 4.39e-16

Agouti protein; The agouti protein regulates pigmentation in the mouse hair follicle producing a black hair with a subapical yellow band. A highly homologous protein agouti signal protein (ASIP)is present in humans and is expressed at highest levels in adipose tissue where it may play a role in energy homeostasis and possibly human pigmentation.


Pssm-ID: 428273  Cd Length: 43  Bit Score: 66.69  E-value: 4.39e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 4501995     80 EPRSSRRCVRLHESCLGQQVPCCDPCATCYCRFFNAFCYCR 120
Cdd:pfam05039   2 RPPPPRRCVRLRESCKPHQVPCCDPCATCYCRFFRAFCYCR 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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