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Conserved domains on  [gi|288541295|ref|NP_001128529|]
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leucine-rich repeat-containing protein 15 isoform a precursor [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-449 4.03e-33

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 131.59  E-value: 4.03e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295  50 IVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQG 129
Cdd:COG4886    7 SLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 130 LDSLESLLLSSNQLLQIQ-PAHFSQCSNLKELQLHGNHLEYIPDgAFDHLVGLTKLNLGKNSLTHIsPRVFQHLGNLQVL 208
Cdd:COG4886   87 LGLTDLGDLTNLTELDLSgNEELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 209 RLYENRLTDIPMGtFDGLVNLQELALQQNQIGLLSPGLFhNNHNLQRLYLSNNHISQLPPSvFMQLPQLNRLTLFGNSLK 288
Cdd:COG4886  165 DLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPEPLG-NLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLT 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 289 ELsPGIFGpMPNLRELWLYDNHISSLPDNvfSNLRQLQVLILSRNQISFISPGAFNGLTELreLSLHTNALQDLDGNVFR 368
Cdd:COG4886  242 DL-PELGN-LTNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGL--NSLLLLLLLLNLLELLI 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 369 MLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQ 448
Cdd:COG4886  316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLT 395


                 .
gi 288541295 449 P 449
Cdd:COG4886  396 T 396
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-449 4.03e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 131.59  E-value: 4.03e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295  50 IVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQG 129
Cdd:COG4886    7 SLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 130 LDSLESLLLSSNQLLQIQ-PAHFSQCSNLKELQLHGNHLEYIPDgAFDHLVGLTKLNLGKNSLTHIsPRVFQHLGNLQVL 208
Cdd:COG4886   87 LGLTDLGDLTNLTELDLSgNEELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 209 RLYENRLTDIPMGtFDGLVNLQELALQQNQIGLLSPGLFhNNHNLQRLYLSNNHISQLPPSvFMQLPQLNRLTLFGNSLK 288
Cdd:COG4886  165 DLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPEPLG-NLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLT 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 289 ELsPGIFGpMPNLRELWLYDNHISSLPDNvfSNLRQLQVLILSRNQISFISPGAFNGLTELreLSLHTNALQDLDGNVFR 368
Cdd:COG4886  242 DL-PELGN-LTNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGL--NSLLLLLLLLNLLELLI 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 369 MLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQ 448
Cdd:COG4886  316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLT 395


                 .
gi 288541295 449 P 449
Cdd:COG4886  396 T 396
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 81-407 1.81e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 79.89  E-value: 1.81e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295  81 NISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQ-VLPIGLFQGLDSLESLLLSSNQLLQIqPAHFSQCSNLKE 159
Cdd:PLN00113 186 NLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLTGPI-PSSLGNLKNLQY 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 160 LQLHGNHLE-YIPDGAFDhLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLT-DIPMGtFDGLVNLQELALQQN 237
Cdd:PLN00113 265 LFLYQNKLSgPIPPSIFS-LQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTgKIPVA-LTSLPRLQVLQLWSN 342

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 238 QIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSVFMQLPQLNRLTLFGNSLKELSPGIFGPMPNLRELWLYDNHISSLPDN 317
Cdd:PLN00113 343 KFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPS 422

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 318 VFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNA----LQDLDGNvfrmlANLQNISLQNNRLRQLPGNIFAN 393
Cdd:PLN00113 423 EFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKffggLPDSFGS-----KRLENLDLSRNQFSGAVPRKLGS 497

                        330
                 ....*....|....
gi 288541295 394 VNGLMAIQLQNNQL 407
Cdd:PLN00113 498 LSELMQLKLSENKL 511
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 151-357 2.61e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 75.21  E-value: 2.61e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 151 FSQCSNLKELQLHGNHLEYIPDgaFDHLVGLTKLNLGKNSLTHIsprvfqhlgnlqvlrlyENrltdipmgtFDGLVNLQ 230
Cdd:cd21340   20 LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI-----------------EN---------LENLVNLK 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 231 ELALQQNQIGLLSpGLfHNNHNLQRLYLSNNhisQLPPSvfmqlpqlNRLTLFGNSLKELSpgifgpmPNLRELWLYDNH 310
Cdd:cd21340   72 KLYLGGNRISVVE-GL-ENLTNLEELHIENQ---RLPPG--------EKLTFDPRSLAALS-------NSLRVLNISGNN 131

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 288541295 311 ISSLPDnvFSNLRQLQVLILSRNQISFISP--GAFNGLTELRELSLHTN 357
Cdd:cd21340  132 IDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
155-215 4.53e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 4.53e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 288541295  155 SNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRL 215
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 402-473 5.64e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 46.61  E-value: 5.64e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 288541295   402 LQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIII 473
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGI 73
LRRCT smart00082
Leucine rich repeat C-terminal domain;
429-468 1.54e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 36.64  E-value: 1.54e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 288541295   429 NPWRCDSDILPLRNWLLLNQPRLGTDTvPVCFSPANVRGQ 468
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVD-LRCASPSSLRGP 39
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-449 4.03e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 131.59  E-value: 4.03e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295  50 IVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQG 129
Cdd:COG4886    7 SLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 130 LDSLESLLLSSNQLLQIQ-PAHFSQCSNLKELQLHGNHLEYIPDgAFDHLVGLTKLNLGKNSLTHIsPRVFQHLGNLQVL 208
Cdd:COG4886   87 LGLTDLGDLTNLTELDLSgNEELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 209 RLYENRLTDIPMGtFDGLVNLQELALQQNQIGLLSPGLFhNNHNLQRLYLSNNHISQLPPSvFMQLPQLNRLTLFGNSLK 288
Cdd:COG4886  165 DLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPEPLG-NLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLT 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 289 ELsPGIFGpMPNLRELWLYDNHISSLPDNvfSNLRQLQVLILSRNQISFISPGAFNGLTELreLSLHTNALQDLDGNVFR 368
Cdd:COG4886  242 DL-PELGN-LTNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGL--NSLLLLLLLLNLLELLI 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 369 MLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQ 448
Cdd:COG4886  316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLT 395


                 .
gi 288541295 449 P 449
Cdd:COG4886  396 T 396
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
156-455 7.00e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 130.82  E-value: 7.00e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 156 NLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLthisprvFQHLGNLQVLRLYENRLTDIPmGTFDGLVNLQELALQ 235
Cdd:COG4886   73 LLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE-------LSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLS 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 236 QNQIGLLSPGLFhNNHNLQRLYLSNNHISQLPPSVFmQLPQLNRLTLFGNSLKELsPGIFGPMPNLRELWLYDNHISSLP 315
Cdd:COG4886  145 NNQLTDLPEPLG-NLTNLKSLDLSNNQLTDLPEELG-NLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLP 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 316 DNvFSNLRQLQVLILSRNQISFISpgAFNGLTELRELSLHTNALQDLDGNVFrmLANLQNISLQNNRLRQLPGNIFANVN 395
Cdd:COG4886  222 EP-LANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLAN--LTNLKTLDLSNNQLTDLKLKELELLL 296

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 396 GLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDT 455
Cdd:COG4886  297 GLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLL 356
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
59-429 8.12e-30

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 121.96  E-value: 8.12e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295  59 WNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLfqgldsleslll 138
Cdd:COG4886   65 LLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEEL------------ 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 139 ssnqllqiqpahfSQCSNLKELQLHGNHLEYIPDgAFDHLVGLTKLNLGKNSLTHIsPRVFQHLGNLQVLRLYENRLTDI 218
Cdd:COG4886  133 -------------ANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 219 PMgTFDGLVNLQELALQQNQIGLLSPGLfHNNHNLQRLYLSNNHISQLPpsVFMQLPQLNRLTLFGNSLKELSPgiFGPM 298
Cdd:COG4886  198 PE-PLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP--LANL 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 299 PNLRELWLYDNHISSLPDNVFSNLRQLQVLIL----SRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQ 374
Cdd:COG4886  272 TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLllllLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 288541295 375 NISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 429
Cdd:COG4886  352 LLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLA 406
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
63-366 1.33e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.37  E-value: 1.33e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295  63 SLQILNTHITELNEsPFLNISALIALRIEKNELSRItPGAFRNLGSLRYLSLANNKLQVLPiglfqgldsleslllssnq 142
Cdd:COG4886  140 ELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLP------------------- 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 143 llqiqpAHFSQCSNLKELQLHGNHLEYIPDgAFDHLVGLTKLNLGKNSLTHISprVFQHLGNLQVLRLYENRLTDIPmgT 222
Cdd:COG4886  199 ------EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLP--P 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 223 FDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSVFMQLPQLNRLTLFGNSLKELSPGIFGPMPNLR 302
Cdd:COG4886  268 LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLL 347

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 288541295 303 ELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNV 366
Cdd:COG4886  348 ALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAV 411
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 81-407 1.81e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 79.89  E-value: 1.81e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295  81 NISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQ-VLPIGLFQGLDSLESLLLSSNQLLQIqPAHFSQCSNLKE 159
Cdd:PLN00113 186 NLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLTGPI-PSSLGNLKNLQY 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 160 LQLHGNHLE-YIPDGAFDhLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLT-DIPMGtFDGLVNLQELALQQN 237
Cdd:PLN00113 265 LFLYQNKLSgPIPPSIFS-LQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTgKIPVA-LTSLPRLQVLQLWSN 342

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 238 QIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSVFMQLPQLNRLTLFGNSLKELSPGIFGPMPNLRELWLYDNHISSLPDN 317
Cdd:PLN00113 343 KFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPS 422

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 318 VFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNA----LQDLDGNvfrmlANLQNISLQNNRLRQLPGNIFAN 393
Cdd:PLN00113 423 EFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKffggLPDSFGS-----KRLENLDLSRNQFSGAVPRKLGS 497

                        330
                 ....*....|....
gi 288541295 394 VNGLMAIQLQNNQL 407
Cdd:PLN00113 498 LSELMQLKLSENKL 511
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 151-357 2.61e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 75.21  E-value: 2.61e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 151 FSQCSNLKELQLHGNHLEYIPDgaFDHLVGLTKLNLGKNSLTHIsprvfqhlgnlqvlrlyENrltdipmgtFDGLVNLQ 230
Cdd:cd21340   20 LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI-----------------EN---------LENLVNLK 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 231 ELALQQNQIGLLSpGLfHNNHNLQRLYLSNNhisQLPPSvfmqlpqlNRLTLFGNSLKELSpgifgpmPNLRELWLYDNH 310
Cdd:cd21340   72 KLYLGGNRISVVE-GL-ENLTNLEELHIENQ---RLPPG--------EKLTFDPRSLAALS-------NSLRVLNISGNN 131

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 288541295 311 ISSLPDnvFSNLRQLQVLILSRNQISFISP--GAFNGLTELRELSLHTN 357
Cdd:cd21340  132 IDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 83-407 1.18e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 77.58  E-value: 1.18e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295  83 SALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKL--QV-----------------------LPIGLFQGLDSLESLL 137
Cdd:PLN00113 164 SSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLvgQIprelgqmkslkwiylgynnlsgeIPYEIGGLTSLNHLDL 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 138 LSSNQLLQIqPAHFSQCSNLKELQLHGNHLE-YIPDGAFDhLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLT 216
Cdd:PLN00113 244 VYNNLTGPI-PSSLGNLKNLQYLFLYQNKLSgPIPPSIFS-LQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFT 321

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 217 -DIPMG---------------TFDGLV--------NLQELALQQNQI------GLLSPG------LFHNN---------- 250
Cdd:PLN00113 322 gKIPVAltslprlqvlqlwsnKFSGEIpknlgkhnNLTVLDLSTNNLtgeipeGLCSSGnlfkliLFSNSlegeipkslg 401

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 251 --HNLQRLYLSNNHISQLPPSVFMQLPQLNRLTLFGNSLKELSPGIFGPMPNLRELWLYDNHIS-SLPDnvFSNLRQLQV 327
Cdd:PLN00113 402 acRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFgGLPD--SFGSKRLEN 479

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 328 LILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLR-QLPGNiFANVNGLMAIQLQNNQ 406
Cdd:PLN00113 480 LDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSgQIPAS-FSEMPVLSQLDLSQNQ 558


                 .
gi 288541295 407 L 407
Cdd:PLN00113 559 L 559
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 93-407 4.61e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 75.65  E-value: 4.61e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295  93 NELSRITPGA-FRNLGSLRYLSLANNKLQ-VLPIGLFQGLDSLESLLLSSNQLLqiqPAHFSQCSNLKELQLHGNHLE-Y 169
Cdd:PLN00113 103 NQLSGPIPDDiFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSGEI---PNDIGSFSSLKVLDLGGNVLVgK 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 170 IPdGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRL-YENRLTDIPMgTFDGLVNLQELALQQNQIGLLSPGLFH 248
Cdd:PLN00113 180 IP-NSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLgYNNLSGEIPY-EIGGLTSLNHLDLVYNNLTGPIPSSLG 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 249 NNHNLQRLYLSNNHIS-QLPPSVFmQLPQLNRLTLFGNSLKELSPGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQV 327
Cdd:PLN00113 258 NLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQV 336

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 328 LILSRNQISFISPGAFNGLTELRELSLHTNALQDL-------DGNVFRMlanlqnISLQNNRLRQLPGNIFAnVNGLMAI 400
Cdd:PLN00113 337 LQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEipeglcsSGNLFKL------ILFSNSLEGEIPKSLGA-CRSLRRV 409


                 ....*..
gi 288541295 401 QLQNNQL 407
Cdd:PLN00113 410 RLQDNSF 416
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 181-381 9.86e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 70.59  E-value: 9.86e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 181 LTKLNLGKNSLTHISprVFQHLGNLQVLRLYENRLTDIPmgtfdglvNLqelalqqnqigllspglfHNNHNLQRLYLSN 260
Cdd:cd21340    4 ITHLYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIE--------NL------------------EFLTNLTHLYLQN 55

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 261 NHISQLPPsvFMQLPQLNRLTLFGNSLKELSpGIFGPmPNLRELwlydnHIS--------SL---PDNVFSNLRQLQVLI 329
Cdd:cd21340   56 NQIEKIEN--LENLVNLKKLYLGGNRISVVE-GLENL-TNLEEL-----HIEnqrlppgeKLtfdPRSLAALSNSLRVLN 126

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 288541295 330 LSRNQISFISPgaFNGLTELRELSLHTNALQDLD--GNVFRMLANLQNISLQNN 381
Cdd:cd21340  127 ISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
155-215 4.53e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 4.53e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 288541295  155 SNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRL 215
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
180-239 4.86e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.00  E-value: 4.86e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295  180 GLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQI 239
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
299-359 7.39e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 7.39e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 288541295  299 PNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNAL 359
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
204-263 1.33e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.85  E-value: 1.33e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295  204 NLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHI 263
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
228-287 3.60e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.69  E-value: 3.60e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295  228 NLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSVFMQLPQLNRLTLFGNSL 287
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 145-428 5.43e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 65.64  E-value: 5.43e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 145 QIQPAHFsQCSNLKELQLHGNHLEY-IPDGAFDHLVGLTKLNLGKNSLTHISPRVFqhLGNLQVLRLYENRLT-DIP--M 220
Cdd:PLN00113  84 KISSAIF-RLPYIQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNMLSgEIPndI 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 221 GTFDglvNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSVFMQLPQLNRLTLFGNSLKELSPGIFGPMPN 300
Cdd:PLN00113 161 GSFS---SLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTS 237

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 301 LRELWL-YDNHISSLPDNvFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQdldGNVFRMLANLQNISL- 378
Cdd:PLN00113 238 LNHLDLvYNNLTGPIPSS-LGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLS---GEIPELVIQLQNLEIl 313

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 288541295 379 ---QNNRLRQLPGNIfANVNGLMAIQLQNNQLENlplGIFDHLGKLCELRLYD 428
Cdd:PLN00113 314 hlfSNNFTGKIPVAL-TSLPRLQVLQLWSNKFSG---EIPKNLGKHNNLTVLD 362
LRR_8 pfam13855
Leucine rich repeat;
323-383 9.76e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.53  E-value: 9.76e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 288541295  323 RQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRL 383
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 150-285 1.35e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 61.34  E-value: 1.35e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 150 HFSQCSNLKELQLHGNHLEYIPDgaFDHLVGLTKLNLGKNSLTHISPrvFQHLGNLQVLRLYENRLtdiPMG---TFD-- 224
Cdd:cd21340   41 NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRL---PPGeklTFDpr 113

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 288541295 225 ---GLVN-LQELALQQNQIGLLSPglFHNNHNLQRLYLSNNHISQLPP--SVFMQLPQLNRLTLFGN 285
Cdd:cd21340  114 slaALSNsLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 81-359 5.49e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.56  E-value: 5.49e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295  81 NISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQ-VLPIGLFQGLDSLESLLLSSNQLLQIqPAHFSQCSNLKE 159
Cdd:PLN00113 282 SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSGEI-PKNLGKHNNLTV 360

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 160 LQLHGNHLE-YIPDGAFDHlVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLT----------------DIPMGT 222
Cdd:PLN00113 361 LDLSTNNLTgEIPEGLCSS-GNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSgelpseftklplvyflDISNNN 439

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 223 FDGLVN--------LQELALQQNQIGLLSPGLFHNNhNLQRLYLSNNHISQLPPSVFMQLPQLNRLTLFGNSLKELSPGI 294
Cdd:PLN00113 440 LQGRINsrkwdmpsLQMLSLARNKFFGGLPDSFGSK-RLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDE 518

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 288541295 295 FGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNAL 359
Cdd:PLN00113 519 LSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHL 583
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
169-411 1.02e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 61.64  E-value: 1.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 169 YIPDGafdhlvgLTKLNLGKNSLTHIsPRVFQhlGNLQVLRLYENRLTDIPMGTFDglvNLQELALQQNQIGLLSPglfH 248
Cdd:PRK15370 196 CIPEQ-------ITTLILDNNELKSL-PENLQ--GNIKTLYANSNQLTSIPATLPD---TIQEMELSINRITELPE---R 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 249 NNHNLQRLYLSNNHISQLPPSvfmqLPQlnrltlfgnslkelspgifgpmpNLRELWLYDNHISSLPDNVFSNLRQLQVL 328
Cdd:PRK15370 260 LPSALQSLDLFHNKISCLPEN----LPE-----------------------ELRYLSVYDNSIRTLPAHLPSGITHLNVQ 312

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 329 ilsRNQISFIsPGAFNglTELRELSLHTNALQDLDGNvfrMLANLQNISLQNNRLRQLPGNIFANVNGLmaiQLQNNQLE 408
Cdd:PRK15370 313 ---SNSLTAL-PETLP--PGLKTLEAGENALTSLPAS---LPPELQVLDVSKNQITVLPETLPPTITTL---DVSRNALT 380


                 ...
gi 288541295 409 NLP 411
Cdd:PRK15370 381 NLP 383
LRR_8 pfam13855
Leucine rich repeat;
252-311 1.35e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 1.35e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295  252 NLQRLYLSNNHISQLPPSVFMQLPQLNRLTLFGNSLKELSPGIFGPMPNLRELWLYDNHI 311
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
157-412 1.51e-09

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 60.95  E-value: 1.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 157 LKELQLHGNHLEYIPDGAfdhlVGLTKLNLGKNSLTHIsPRVFQHLGNLQVlrlYENRLTDIPMGTfdglVNLQELALQQ 236
Cdd:PRK15387 244 LRTLEVSGNQLTSLPVLP----PGLLELSIFSNPLTHL-PALPSGLCKLWI---FGNQLTSLPVLP----PGLQELSVSD 311

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 237 NQIGLLsPGLfhnNHNLQRLYLSNNHISQLPpsvfmQLPQ-LNRLTLFGNSLKELSPgifgpMPN-LRELWLYDNHISSL 314
Cdd:PRK15387 312 NQLASL-PAL---PSELCKLWAYNNQLTSLP-----TLPSgLQELSVSDNQLASLPT-----LPSeLYKLWAYNNRLTSL 377

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 315 PdNVFSNLRQlqvLILSRNQISFIS--PgafnglTELRELSLHTNALQDLDgnvfRMLANLQNISLQNNRLRQLPGNIFa 392
Cdd:PRK15387 378 P-ALPSGLKE---LIVSGNRLTSLPvlP------SELKELMVSGNRLTSLP----MLPSGLLSLSVYRNQLTRLPESLI- 442

                        250       260
                 ....*....|....*....|
gi 288541295 393 NVNGLMAIQLQNNQLENLPL 412
Cdd:PRK15387 443 HLSSETTVNLEGNPLSERTL 462
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 63-309 1.71e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 59.29  E-value: 1.71e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295  63 SLQILNTHITELNESP---------FLNISALIALRIEKNELSRITPGAFRNL---GSLRYLSLANNKLQVLPIGLfqgl 130
Cdd:cd00116   52 SLKELCLSLNETGRIPrglqsllqgLTKGCGLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGDRGLRL---- 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 131 dsleslllssnqllqIQPAHFSQCSNLKELQLHGNHLEYIP----DGAFDHLVGLTKLNLGKNSLTHISPRV----FQHL 202
Cdd:cd00116  128 ---------------LAKGLKDLPPALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGDAGIRAlaegLKAN 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 203 GNLQVLRLYENRLTDIPM----GTFDGLVNLQELALQQNQIGL-----LSPGLFHNNHNLQRLYLSNNHISQlppSVFMQ 273
Cdd:cd00116  193 CNLEVLDLNNNGLTDEGAsalaETLASLKSLEVLNLGDNNLTDagaaaLASALLSPNISLLTLSLSCNDITD---DGAKD 269

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 288541295 274 L-------PQLNRLTLFGNSLKE-----LSPGIFGPMPNLRELWLYDN 309
Cdd:cd00116  270 LaevlaekESLLELDLRGNKFGEegaqlLAESLLEPGNELESLWVKDD 317
LRR_8 pfam13855
Leucine rich repeat;
275-335 1.91e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 1.91e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 288541295  275 PQLNRLTLFGNSLKELSPGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQI 335
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 277-430 6.61e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.33  E-value: 6.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 277 LNRLT---LFGNSLKELspGIFGPMPNLRELWLYDNHISSLP--------------DNV------FSNLRQLQVLILSRN 333
Cdd:cd21340    1 LKRIThlyLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIEnlefltnlthlylqNNQiekienLENLVNLKKLYLGGN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 334 QISFISpgAFNGLTELRELSLhtnALQDLD-GNVF----RMLANLQNiSLQ-----NNRLRQLpgNIFANVNGLMAIQLQ 403
Cdd:cd21340   79 RISVVE--GLENLTNLEELHI---ENQRLPpGEKLtfdpRSLAALSN-SLRvlnisGNNIDSL--EPLAPLRNLEQLDAS 150

                        170       180
                 ....*....|....*....|....*....
gi 288541295 404 NNQLENLP--LGIFDHLGKLCELRLYDNP 430
Cdd:cd21340  151 NNQISDLEelLDLLSSWPSLRELDLTGNP 179
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 157-383 1.85e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 56.21  E-value: 1.85e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 157 LKELQLHGNHLEYIPDG------AFDHLVGLTKLNLGKNSLTHISPRVFQHLgnlqvLRLYenrltdipmgtfdglvNLQ 230
Cdd:cd00116   53 LKELCLSLNETGRIPRGlqsllqGLTKGCGLQELDLSDNALGPDGCGVLESL-----LRSS----------------SLQ 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 231 ELALQQNQIG-----LLSPGLFHNNHNLQRLYLSNNHISQLP----PSVFMQLPQLNRLTLFGNSLKElsPGI------F 295
Cdd:cd00116  112 ELKLNNNGLGdrglrLLAKGLKDLPPALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGD--AGIralaegL 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 296 GPMPNLRELWLYDNHISSLPD----NVFSNLRQLQVLILSRNQISF-----ISPGAFNGLTELRELSLHTNALQDLDG-N 365
Cdd:cd00116  190 KANCNLEVLDLNNNGLTDEGAsalaETLASLKSLEVLNLGDNNLTDagaaaLASALLSPNISLLTLSLSCNDITDDGAkD 269

                        250       260
                 ....*....|....*....|.
gi 288541295 366 VFRMLAN---LQNISLQNNRL 383
Cdd:cd00116  270 LAEVLAEkesLLELDLRGNKF 290
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
155-335 6.70e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 55.47  E-value: 6.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 155 SNLKELQLHGNHLEYIPDGAFDhlvGLTKLNLGKNSLTHIS---PRVFQHL---------------GNLQVLRLYENRLT 216
Cdd:PRK15370 220 GNIKTLYANSNQLTSIPATLPD---TIQEMELSINRITELPerlPSALQSLdlfhnkisclpenlpEELRYLSVYDNSIR 296

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 217 DIPMGTFDGLVnlqELALQQNQIGLLSPGLfhnNHNLQRLYLSNNHISQLPPSVFMQLPQL----NRLTLfgnsLKELSP 292
Cdd:PRK15370 297 TLPAHLPSGIT---HLNVQSNSLTALPETL---PPGLKTLEAGENALTSLPASLPPELQVLdvskNQITV----LPETLP 366

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 288541295 293 gifgpmPNLRELWLYDNHISSLPDNVFSNLRQLQVlilSRNQI 335
Cdd:PRK15370 367 ------PTITTLDVSRNALTNLPENLPAALQIMQA---SRNNL 400
LRR_8 pfam13855
Leucine rich repeat;
60-119 3.14e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 3.14e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295   60 NAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKL 119
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
108-191 1.48e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 1.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295  108 SLRYLSLANNKLQVLPIGLFQGldsleslllssnqllqiqpahfsqCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLG 187
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKG------------------------LSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLS 57


                  ....
gi 288541295  188 KNSL 191
Cdd:pfam13855  58 GNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
67-352 1.67e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.24  E-value: 1.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295  67 LNTHITEL--NESPFLNISALIALRIEKNELS--RITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGldsleslllssnq 142
Cdd:PRK15370 218 LQGNIKTLyaNSNQLTSIPATLPDTIQEMELSinRITELPERLPSALQSLDLFHNKISCLPENLPEE------------- 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 143 llqiqpahfsqcsnLKELQLHGNHLEYIPdgafDHL-VGLTKLNLGKNSLTHIsPRVFQHlgNLQVLRLYENRLTDIPMG 221
Cdd:PRK15370 285 --------------LRYLSVYDNSIRTLP----AHLpSGITHLNVQSNSLTAL-PETLPP--GLKTLEAGENALTSLPAS 343

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 222 TFDGlvnLQELALQQNQIGLLSPGLfhnNHNLQRLYLSNNHISQLPPSV--FMQLPQLNRLTLFgnSLKELSPGIFGPMP 299
Cdd:PRK15370 344 LPPE---LQVLDVSKNQITVLPETL---PPTITTLDVSRNALTNLPENLpaALQIMQASRNNLV--RLPESLPHFRGEGP 415

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 288541295 300 NLRELWLYDNHISslpDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELREL 352
Cdd:PRK15370 416 QPTRIIVEYNPFS---ERTIQNMQRLMSSVGYQGPRVLFAMGDFSIVRVTRPL 465
LRR_8 pfam13855
Leucine rich repeat;
372-430 2.28e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 2.28e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 288541295  372 NLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNP 430
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
88-167 2.49e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 2.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295   88 LRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPiglfqgldsleslllssnqllqiqPAHFSQCSNLKELQLHGNHL 167
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLS------------------------PGAFSGLPSLRYLDLSGNRL 61
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 151-278 3.59e-05

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 43.69  E-value: 3.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295  151 FSQCsNLKELQLhGNHLEYIPDGAFDHLVGLTKLNLGkNSLTHISPRVFQHLgNLQVLRLYENrLTDIPMGTFDGLVNLQ 230
Cdd:pfam13306   8 FYNC-SLTSITI-PSSLTSIGEYAFSNCTSLKSITLP-SSLTSIGSYAFYNC-SLTSITIPSS-LTSIGEYAFSNCSNLK 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 288541295  231 ELALQQN--QIGllsPGLFHNNhNLQRLYLSNNhISQLPPSVFMQLPQLN 278
Cdd:pfam13306  83 SITLPSNltSIG---SYAFSNC-SLKSITIPSS-VTTIGSYAFSNCSNLK 127
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 402-473 5.64e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 46.61  E-value: 5.64e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 288541295   402 LQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIII 473
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGI 73
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 157-473 1.91e-04

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 44.48  E-value: 1.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295  157 LKELQLHG-NHLEYIPDGAfdHLVGLTKLNLGKNSLTHISPRVFQhlgNLQVLRLYENRLTDIPMGTfdGLVNLQELALQ 235
Cdd:PLN03210  683 LEDLDMSRcENLEILPTGI--NLKSLYRLNLSGCSRLKSFPDIST---NISWLDLDETAIEEFPSNL--RLENLDELILC 755

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295  236 QNQIG-------LLSPGLFHNNHNLQRLYLSNNHISQLPPSVFMQLPQLNRLTLFG-NSLKELSPGIfgpmpNLRELWLY 307
Cdd:PLN03210  756 EMKSEklwervqPLTPLMTMLSPSLTRLFLSDIPSLVELPSSIQNLHKLEHLEIENcINLETLPTGI-----NLESLESL 830

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295  308 D-NHISSL---PDnVFSNLRQlqvLILSRnqisfispgafnglTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRL 383
Cdd:PLN03210  831 DlSGCSRLrtfPD-ISTNISD---LNLSR--------------TGIEEVPWWIEKFSNLSFLDMNGCNNLQRVSLNISKL 892

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295  384 RQLPGNIFANVNGLMAIQLQNNQLE--NLPLGIFDHLGKLCELRLYdNPWRCDSDILpLRNWLLLNQPRLGTDTVPVCFS 461
Cdd:PLN03210  893 KHLETVDFSDCGALTEASWNGSPSEvaMATDNIHSKLPSTVCINFI-NCFNLDQEAL-LQQQSIFKQLILSGEEVPSYFT 970

                         330
                  ....*....|..
gi 288541295  462 PANVrGQSLIII 473
Cdd:PLN03210  971 HRTT-GASLTNI 981
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 83-269 1.39e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 1.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295  83 SALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQvlpiglfqGLDSLESLLLSSNQLLQIQPAHF-------SQCS 155
Cdd:PLN00113 404 RSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQ--------GRINSRKWDMPSLQMLSLARNKFfgglpdsFGSK 475

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 156 NLKELQLHGNHL-EYIPDGaFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLT-DIPMGtFDGLVNLQELA 233
Cdd:PLN00113 476 RLENLDLSRNQFsGAVPRK-LGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSgQIPAS-FSEMPVLSQLD 553

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 288541295 234 LQQNQIGLLSPGLFHNNHNLQRLYLSNNHI-SQLPPS 269
Cdd:PLN00113 554 LSQNQLSGEIPKNLGNVESLVQVNISHNHLhGSLPST 590
LRRCT smart00082
Leucine rich repeat C-terminal domain;
429-468 1.54e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 36.64  E-value: 1.54e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 288541295   429 NPWRCDSDILPLRNWLLLNQPRLGTDTvPVCFSPANVRGQ 468
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVD-LRCASPSSLRGP 39
LRR smart00370
Leucine-rich repeats, outliers;
298-321 1.91e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 1.91e-03
                           10        20
                   ....*....|....*....|....
gi 288541295   298 MPNLRELWLYDNHISSLPDNVFSN 321
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
298-321 1.91e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 1.91e-03
                           10        20
                   ....*....|....*....|....
gi 288541295   298 MPNLRELWLYDNHISSLPDNVFSN 321
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 299-340 3.26e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.68  E-value: 3.26e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 288541295  299 PNLRELWLYDNHISSLPdnVFSNLRQLQVLILSRN-QISFISP 340
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNnKITDLSD 41
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 249-428 4.89e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.83  E-value: 4.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 249 NNHNLQRLYLSNNHISQLPPSVFMQLPQLNRLTLFGNSLKELSPG-IFGPMPNLRELWLYDNHIS-SLPDNVFSNLRQLQ 326
Cdd:PLN00113  67 NSSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPDdIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLD 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 288541295 327 vliLSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNrlrQLPGNIFANVNGLMAIQLQNNQ 406
Cdd:PLN00113 147 ---LSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASN---QLVGQIPRELGQMKSLKWIYLG 220

                        170       180
                 ....*....|....*....|..
gi 288541295 407 LENLPLGIFDHLGKLCELRLYD 428
Cdd:PLN00113 221 YNNLSGEIPYEIGGLTSLNHLD 242
LRR smart00370
Leucine-rich repeats, outliers;
251-271 6.51e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 6.51e-03
                           10        20
                   ....*....|....*....|.
gi 288541295   251 HNLQRLYLSNNHISQLPPSVF 271
Cdd:smart00370   2 PNLRELDLSNNQLSSLPPGAF 22
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
251-271 6.51e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 6.51e-03
                           10        20
                   ....*....|....*....|.
gi 288541295   251 HNLQRLYLSNNHISQLPPSVF 271
Cdd:smart00369   2 PNLRELDLSNNQLSSLPPGAF 22
LRR smart00370
Leucine-rich repeats, outliers;
322-345 8.49e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 33.86  E-value: 8.49e-03
                           10        20
                   ....*....|....*....|....
gi 288541295   322 LRQLQVLILSRNQISFISPGAFNG 345
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
322-345 8.49e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 33.86  E-value: 8.49e-03
                           10        20
                   ....*....|....*....|....
gi 288541295   322 LRQLQVLILSRNQISFISPGAFNG 345
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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