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Conserved domains on  [gi|197927168|ref|NP_001128217|]
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leucine-rich repeat transmembrane neuronal protein 4 isoform a precursor [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
71-311 1.57e-27

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 115.03  E-value: 1.57e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168  71 NSIQKLKSNQFAGLNQLIWLYLDHNyissvdeDAFQGIRRLKELILSSNKITYLhNKTFHPVPNLRNLDLSYNKLQTLqS 150
Cdd:COG4886   82 LSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-P 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168 151 EQFKGLRKLIILHLRSNSLKTVPiRVFQDCRNLDFLDLGYNRLRSLSrnafagllklkelhlehnqfskinfAHFPRLFN 230
Cdd:COG4886  153 EPLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLP-------------------------EPLGNLTN 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168 231 LRSIYLQWNRIRSISQGLTwTWSSLHNLDLSGNDIQGIEpgTFKCLPNLQKLNLDSNKLTNISQETvnAWISLISITLSG 310
Cdd:COG4886  207 LEELDLSGNQLTDLPEPLA-NLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSN 281


                 .
gi 197927168 311 N 311
Cdd:COG4886  282 N 282
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
71-311 1.57e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 115.03  E-value: 1.57e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168  71 NSIQKLKSNQFAGLNQLIWLYLDHNyissvdeDAFQGIRRLKELILSSNKITYLhNKTFHPVPNLRNLDLSYNKLQTLqS 150
Cdd:COG4886   82 LSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-P 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168 151 EQFKGLRKLIILHLRSNSLKTVPiRVFQDCRNLDFLDLGYNRLRSLSrnafagllklkelhlehnqfskinfAHFPRLFN 230
Cdd:COG4886  153 EPLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLP-------------------------EPLGNLTN 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168 231 LRSIYLQWNRIRSISQGLTwTWSSLHNLDLSGNDIQGIEpgTFKCLPNLQKLNLDSNKLTNISQETvnAWISLISITLSG 310
Cdd:COG4886  207 LEELDLSGNQLTDLPEPLA-NLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSN 281


                 .
gi 197927168 311 N 311
Cdd:COG4886  282 N 282
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 90-311 9.96e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 76.36  E-value: 9.96e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168  90 LYLDHNYISSVDEDAFqgIRRLKELILSSNKITYLHNktFHPVPNLRNLDLSYNKLQTLqsEQFKGLRKLIILHLRSNSl 169
Cdd:cd21340    7 LYLNDKNITKIDNLSL--CKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNR- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168 170 ktvpIRV---FQDCRNLDFLDLGYNRLRSlsrnafagllklkelhleHNQFskinfahfprLFNLRSIylqwnriRSISQ 246
Cdd:cd21340   80 ----ISVvegLENLTNLEELHIENQRLPP------------------GEKL----------TFDPRSL-------AALSN 120

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 197927168 247 gltwtwsSLHNLDLSGNDIQGIEPgtFKCLPNLQKLNLDSNKLTNISQ--ETVNAWISLISITLSGN 311
Cdd:cd21340  121 -------SLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
133-193 2.63e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 70.25  E-value: 2.63e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 197927168  133 PNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRL 193
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 55-311 1.83e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.55  E-value: 1.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168  55 IPENISGGSQGLSLRF--NSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPV 132
Cdd:PLN00113 276 IPPSIFSLQKLISLDLsdNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKH 355

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168 133 PNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDfldlgynRLRsLSRNAFAGLLKlkelhl 212
Cdd:PLN00113 356 NNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLR-------RVR-LQDNSFSGELP------ 421

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168 213 ehNQFSKINFAHF-------------PRLFNLRSIYLQWNRIRSISQGLTWTWSS--LHNLDLSGNDIQGIEPGTFKCLP 277
Cdd:PLN00113 422 --SEFTKLPLVYFldisnnnlqgrinSRKWDMPSLQMLSLARNKFFGGLPDSFGSkrLENLDLSRNQFSGAVPRKLGSLS 499

                        250       260       270
                 ....*....|....*....|....*....|....
gi 197927168 278 NLQKLNLDSNKLTNISQETVNAWISLISITLSGN 311
Cdd:PLN00113 500 ELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHN 533
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
71-311 1.57e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 115.03  E-value: 1.57e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168  71 NSIQKLKSNQFAGLNQLIWLYLDHNyissvdeDAFQGIRRLKELILSSNKITYLhNKTFHPVPNLRNLDLSYNKLQTLqS 150
Cdd:COG4886   82 LSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-P 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168 151 EQFKGLRKLIILHLRSNSLKTVPiRVFQDCRNLDFLDLGYNRLRSLSrnafagllklkelhlehnqfskinfAHFPRLFN 230
Cdd:COG4886  153 EPLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLP-------------------------EPLGNLTN 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168 231 LRSIYLQWNRIRSISQGLTwTWSSLHNLDLSGNDIQGIEpgTFKCLPNLQKLNLDSNKLTNISQETvnAWISLISITLSG 310
Cdd:COG4886  207 LEELDLSGNQLTDLPEPLA-NLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSN 281


                 .
gi 197927168 311 N 311
Cdd:COG4886  282 N 282
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-311 5.33e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.55  E-value: 5.33e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168  43 KIVYCESHAFADIPENISGGS--QGLSLRFNSIQKLkSNQFAGLNQLIWLYLDHNYISSVDEdAFQGIRRLKELILSSNK 120
Cdd:COG4886  116 ESLDLSGNQLTDLPEELANLTnlKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQ 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168 121 ITYLHnKTFHPVPNLRNLDLSYNKLQTLqSEQFKGLRKLIILHLRSNSLKTVPirVFQDCRNLDFLDLGYNRLRSLSrnA 200
Cdd:COG4886  194 ITDLP-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLP--P 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168 201 FAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQ 280
Cdd:COG4886  268 LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLL 347

                        250       260       270
                 ....*....|....*....|....*....|.
gi 197927168 281 KLNLDSNKLTNISQETVNAWISLISITLSGN 311
Cdd:COG4886  348 ALLTLLLLLNLLSLLLTLLLTLGLLGLLEAT 378
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
63-311 2.27e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 90.76  E-value: 2.27e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168  63 SQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSY 142
Cdd:COG4886   26 LLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSG 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168 143 NklqtlqsEQFKGLRKLIILHLRSNSLKTVPIRvFQDCRNLDFLDLGYNRLRSLSRNafagllklkelhlehnqfskinf 222
Cdd:COG4886  106 N-------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPEP----------------------- 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168 223 ahFPRLFNLRSIYLQWNRIRSISQGLTwTWSSLHNLDLSGNDIQGIePGTFKCLPNLQKLNLDSNKLTNISQEtVNAWIS 302
Cdd:COG4886  155 --LGNLTNLKSLDLSNNQLTDLPEELG-NLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEP-LANLTN 229


                 ....*....
gi 197927168 303 LISITLSGN 311
Cdd:COG4886  230 LETLDLSNN 238
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 90-311 9.96e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 76.36  E-value: 9.96e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168  90 LYLDHNYISSVDEDAFqgIRRLKELILSSNKITYLHNktFHPVPNLRNLDLSYNKLQTLqsEQFKGLRKLIILHLRSNSl 169
Cdd:cd21340    7 LYLNDKNITKIDNLSL--CKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNR- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168 170 ktvpIRV---FQDCRNLDFLDLGYNRLRSlsrnafagllklkelhleHNQFskinfahfprLFNLRSIylqwnriRSISQ 246
Cdd:cd21340   80 ----ISVvegLENLTNLEELHIENQRLPP------------------GEKL----------TFDPRSL-------AALSN 120

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 197927168 247 gltwtwsSLHNLDLSGNDIQGIEPgtFKCLPNLQKLNLDSNKLTNISQ--ETVNAWISLISITLSGN 311
Cdd:cd21340  121 -------SLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
133-193 2.63e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 70.25  E-value: 2.63e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 197927168  133 PNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRL 193
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-265 4.15e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.67  E-value: 4.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168  43 KIVYCESHAFADIPENISGGS--QGLSLRFNSIQKLkSNQFAGLNQLIWLYLDHNYISSVDEDaFQGIRRLKELILSSNK 120
Cdd:COG4886  162 KSLDLSNNQLTDLPEELGNLTnlKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQ 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168 121 ITYLHNktFHPVPNLRNLDLSYNKLQTLQSEqfKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNA 200
Cdd:COG4886  240 LTDLPE--LGNLTNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI 315

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 197927168 201 FAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDI 265
Cdd:COG4886  316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLL 380
LRR_8 pfam13855
Leucine rich repeat;
86-145 5.26e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.78  E-value: 5.26e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168   86 QLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKL 145
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
66-121 2.17e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.16  E-value: 2.17e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 197927168   66 LSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKI 121
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
109-169 4.30e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 4.30e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 197927168  109 RRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSL 169
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
230-289 7.31e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.92  E-value: 7.31e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168  230 NLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKL 289
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
253-311 4.86e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 4.86e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 197927168  253 SSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQetvNAWI---SLISITLSGN 311
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSP---GAFSglpSLRYLDLSGN 59
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 55-311 1.83e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.55  E-value: 1.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168  55 IPENISGGSQGLSLRF--NSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPV 132
Cdd:PLN00113 276 IPPSIFSLQKLISLDLsdNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKH 355

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168 133 PNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDfldlgynRLRsLSRNAFAGLLKlkelhl 212
Cdd:PLN00113 356 NNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLR-------RVR-LQDNSFSGELP------ 421

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168 213 ehNQFSKINFAHF-------------PRLFNLRSIYLQWNRIRSISQGLTWTWSS--LHNLDLSGNDIQGIEPGTFKCLP 277
Cdd:PLN00113 422 --SEFTKLPLVYFldisnnnlqgrinSRKWDMPSLQMLSLARNKFFGGLPDSFGSkrLENLDLSRNQFSGAVPRKLGSLS 499

                        250       260       270
                 ....*....|....*....|....*....|....
gi 197927168 278 NLQKLNLDSNKLTNISQETVNAWISLISITLSGN 311
Cdd:PLN00113 500 ELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHN 533
LRR_8 pfam13855
Leucine rich repeat;
157-241 2.78e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 2.78e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168  157 RKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGllklkelhlehnqfskinfahfprLFNLRSIYL 236
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSG------------------------LPSLRYLDL 56


                  ....*
gi 197927168  237 QWNRI 241
Cdd:pfam13855  57 SGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 84-290 1.27e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.43  E-value: 1.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168  84 LNQLIWLYLDHNYISSVDEDAFQGIRR---LKELILSSNKITYLHNKTF-----HPVPNLRNLDLSYNKLQTLQSEQ--- 152
Cdd:cd00116   80 GCGLQELDLSDNALGPDGCGVLESLLRsssLQELKLNNNGLGDRGLRLLakglkDLPPALEKLVLGRNRLEGASCEAlak 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168 153 -FKGLRKLIILHLRSNSLKTVPIRV----FQDCRNLDFLDLGYNRLRSLSRNAFAGLlklkelhlehnqfskinfahFPR 227
Cdd:cd00116  160 aLRANRDLKELNLANNGIGDAGIRAlaegLKANCNLEVLDLNNNGLTDEGASALAET--------------------LAS 219

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 197927168 228 LFNLRSIYLQWNRIRS-----ISQGLTWTWSSLHNLDLSGNDIQGIEPGTF----KCLPNLQKLNLDSNKLT 290
Cdd:cd00116  220 LKSLEVLNLGDNNLTDagaaaLASALLSPNISLLTLSLSCNDITDDGAKDLaevlAEKESLLELDLRGNKFG 291
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
86-294 1.64e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.24  E-value: 1.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168  86 QLIWLYLDHNYISSVDEDaFQGirRLKELILSSNKITYLHNKtfhpVPN-LRNLDLSYNKLQTLQSEQFKGLRKLIILHl 164
Cdd:PRK15370 200 QITTLILDNNELKSLPEN-LQG--NIKTLYANSNQLTSIPAT----LPDtIQEMELSINRITELPERLPSALQSLDLFH- 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168 165 rsNSLKTVPIRVFQDCRNLDFLDlgyNRLRSLSRNAFAGLLKLkelhlehNQFSKiNFAHFPRLF--NLRSIYLQWNRIR 242
Cdd:PRK15370 272 --NKISCLPENLPEELRYLSVYD---NSIRTLPAHLPSGITHL-------NVQSN-SLTALPETLppGLKTLEAGENALT 338

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 197927168 243 SISQGLTwtwSSLHNLDLSGNDIQgIEPGTFKclPNLQKLNLDSNKLTNISQ 294
Cdd:PRK15370 339 SLPASLP---PELQVLDVSKNQIT-VLPETLP--PTITTLDVSRNALTNLPE 384
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 57-311 2.23e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.62  E-value: 2.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168  57 ENISGGSQGLSLRFNSIQ--KLKSNQFAGlnqliwlyldhnyisSVDEDAFQGIRRLKELILSSNKITYLHNKTFhpVPN 134
Cdd:PLN00113  79 KNISGKISSAIFRLPYIQtiNLSNNQLSG---------------PIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPN 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168 135 LRNLDLSYNKLQtlqseqfkglrkliilhlrsnslKTVP--IRVFQdcrNLDFLDLGYNRLRSLSRNAFAGLLKLKELHL 212
Cdd:PLN00113 142 LETLDLSNNMLS-----------------------GEIPndIGSFS---SLKVLDLGGNVLVGKIPNSLTNLTSLEFLTL 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168 213 EHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNI 292
Cdd:PLN00113 196 ASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGP 275

                        250
                 ....*....|....*....
gi 197927168 293 SQETVNAWISLISITLSGN 311
Cdd:PLN00113 276 IPPSIFSLQKLISLDLSDN 294
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 61-311 2.12e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 47.09  E-value: 2.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168  61 GGSQGLSLRFNSIQKLKSNQFAGLNQLIWL---YLDHNYISSvdedafQGIRRLKE----------LILSSNKITYL--- 124
Cdd:COG5238  153 GNAVHLLGLAARLGLLAAISMAKALQNNSVetvYLGCNQIGD------EGIEELAEaltqnttvttLWLKRNPIGDEgae 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168 125 -------HNKTfhpvpnLRNLDLSYNKLqtlqseqfkGLRKLIIL--HLRSNslktvpirvfqdcRNLDFLDLGYNRL-- 193
Cdd:COG5238  227 ilaealkGNKS------LTTLDLSNNQI---------GDEGVIALaeALKNN-------------TTVETLYLSGNQIga 278

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168 194 ---RSLSrNAFAGLLKLKELHLEHNQF---SKINFA-HFPRLFNLRSIYLQWNRI-----RSISQGLtWTWSSLHNLDLS 261
Cdd:COG5238  279 egaIALA-KALQGNTTLTSLDLSVNRIgdeGAIALAeGLQGNKTLHTLNLAYNGIgaqgaIALAKAL-QENTTLHSLDLS 356

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 197927168 262 GNDI--QGIEpGTFKCL---PNLQKLNLDSNKLTNISQETVNAWI---SLISITLSGN 311
Cdd:COG5238  357 DNQIgdEGAI-ALAKYLegnTTLRELNLGKNNIGKQGAEALIDALqtnRLHTLILDGN 413
LRR_9 pfam14580
Leucine-rich repeat;
66-185 2.52e-05

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 45.14  E-value: 2.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168   66 LSLRFNSIQKLKsNQFAGLNQLIWLYLDHNYISSVDedAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKL 145
Cdd:pfam14580  24 LDLRGYKIPIIE-NLGATLDQFDTIDFSDNEIRKLD--GFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNL 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 197927168  146 QTL-QSEQFKGLRKLIILHLRSNSLKTVP------IRVFQDCRNLDF 185
Cdd:pfam14580 101 QELgDLDPLASLKKLTFLSLLRNPVTNKPhyrlyvIYKVPQLRLLDF 147
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 133-297 3.67e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.19  E-value: 3.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168 133 PNLRNLDLSYNKLQTLQSEQFKGLRK---LIILHLRSNSL-----KTVpIRVFQDCR-NLDFLDLGYNRLRSLSRNAFAG 203
Cdd:cd00116   81 CGLQELDLSDNALGPDGCGVLESLLRsssLQELKLNNNGLgdrglRLL-AKGLKDLPpALEKLVLGRNRLEGASCEALAK 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168 204 LLKLKEL----HLEHNQFSKINFAH----FPRLFNLRSIYLQWNRIRS-----ISQGLTwTWSSLHNLDLSGN-----DI 265
Cdd:cd00116  160 ALRANRDlkelNLANNGIGDAGIRAlaegLKANCNLEVLDLNNNGLTDegasaLAETLA-SLKSLEVLNLGDNnltdaGA 238

                        170       180       190
                 ....*....|....*....|....*....|..
gi 197927168 266 QGIEPGTFKCLPNLQKLNLDSNKLTNISQETV 297
Cdd:cd00116  239 AALASALLSPNISLLTLSLSCNDITDDGAKDL 270
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 254-293 8.18e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 40.31  E-value: 8.18e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 197927168  254 SLHNLDLSGNDIQGIEPgtFKCLPNLQKLNLDSN-KLTNIS 293
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNnKITDLS 40
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 76-193 1.45e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.84  E-value: 1.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168  76 LKSNQFAG--------LNQLIWLYLDHNYISSVDEDAFqGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQT 147
Cdd:PLN00113 435 ISNNNLQGrinsrkwdMPSLQMLSLARNKFFGGLPDSF-GSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSG 513

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 197927168 148 LQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRL 193
Cdd:PLN00113 514 EIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQL 559
PLN03150 PLN03150
hypothetical protein; Provisional
 226-290 3.66e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.65  E-value: 3.66e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 197927168 226 PRLFNLRSIYLQWNRIR---SISQGltwTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLT 290
Cdd:PLN03150 439 SKLRHLQSINLSGNSIRgniPPSLG---SITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLS 503
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 95-183 1.44e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 39.07  E-value: 1.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168   95 NYISSVDEDAFQGIRRLKELILSSN---------------------KITYLHNKTFHPVPNLRNLDLSyNKLQTLQSEQF 153
Cdd:pfam13306  20 SSLTSIGEYAFSNCTSLKSITLPSSltsigsyafyncsltsitipsSLTSIGEYAFSNCSNLKSITLP-SNLTSIGSYAF 98

                          90       100       110
                  ....*....|....*....|....*....|..
gi 197927168  154 KG--LRKLIIlhlrSNSLKTVPIRVFQDCRNL 183
Cdd:pfam13306  99 SNcsLKSITI----PSSVTTIGSYAFSNCSNL 126
LRR_9 pfam14580
Leucine-rich repeat;
215-291 2.00e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 39.36  E-value: 2.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168  215 NQFSKINFA--------HFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQ---GIEPgtFKCLPNLQKLN 283
Cdd:pfam14580  42 DQFDTIDFSdneirkldGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQelgDLDP--LASLKKLTFLS 119


                  ....*...
gi 197927168  284 LDSNKLTN 291
Cdd:pfam14580 120 LLRNPVTN 127
PLN03150 PLN03150
hypothetical protein; Provisional
 251-311 2.45e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.95  E-value: 2.45e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 197927168 251 TWSSLH---NLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGN 311
Cdd:PLN03150 437 DISKLRhlqSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGN 500
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 133-167 3.41e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.68  E-value: 3.41e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 197927168  133 PNLRNLDLSYNKLQTLQSeqFKGLRKLIILHLRSN 167
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP--LAKLPNLETLDLSGN 33
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 66-145 6.75e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.45  E-value: 6.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927168  66 LSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKL 145
Cdd:PLN00113 480 LDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQL 559
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 110-147 8.21e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 8.21e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 197927168  110 RLKELILSSNKITYLhnKTFHPVPNLRNLDLSYNKLQT 147
Cdd:pfam12799   2 NLEVLDLSNNQITDI--PPLAKLPNLETLDLSGNNKIT 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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