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Conserved domains on  [gi|196115158|ref|NP_001124490|]
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cip1-interacting zinc finger protein isoform 4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 111-402 8.64e-09

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.57  E-value: 8.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  111 PSLTPPQLATPNLQQFFPQATRQSLLGPPPVGVPMNPSQFNLSGRNPQKQARTSSSTTPNRkdsssqtmpvedkSDPPEG 190
Cdd:PHA03247 2708 PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPA-------------PAPPAA 2774

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  191 SEEAAEPRMDTPEDQDLPPCPEDiAKEKRTPAPEPEPCEAselPAKRLRSSEEPTEKEPPgqlqvkaQPQARMTVPKQTQ 270
Cdd:PHA03247 2775 PAAGPPRRLTRPAVASLSESRES-LPSPWDPADPPAAVLA---PAAALPPAASPAGPLPP-------PTSAQPTAPPPPP 2843

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  271 TPDLLPEALEAQVLP----RFQPRVLQVQAQVQSQTQPRIPS-TDTQVQPKLQKQAQTQTSPEHLVLQqkqvqpqlqqea 345
Cdd:PHA03247 2844 GPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRRlARPAVSRSTESFALPPDQPERPPQP------------ 2911

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 196115158  346 EPQKQVQPQVHTQAQPSVQPQEHPPAQVSVQPPEQTHEQPHTQPQVSLLAPEQTPVV 402
Cdd:PHA03247 2912 QAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALV 2968
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 606-630 1.78e-05

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


:

Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 42.16  E-value: 1.78e-05
                          10        20
                  ....*....|....*....|....*
gi 196115158  606 FCTVCNRYFKTPRKFVEHVKSQGHK 630
Cdd:pfam12171   3 YCVLCDKYFKSENALQNHLKSKKHK 27
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 512-541 5.83e-04

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


:

Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 38.00  E-value: 5.83e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 196115158   512 QFFCYICKASCSSQQEFQDHMSEPQHQQRL 541
Cdd:smart00451   3 GFYCKLCNVTFTDEISVEAHLKGKKHKKNV 32
UFD2 super family cl40793
U1-like Zn-finger-containing protein [General function prediction only];
586-637 5.67e-03

U1-like Zn-finger-containing protein [General function prediction only];


The actual alignment was detected with superfamily member COG5112:

Pssm-ID: 227443  Cd Length: 126  Bit Score: 37.75  E-value: 5.67e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158 586 DLIQHRRTQDHKIAKQSLRP--------FCTVCNRYFKTPRKFVEHVKSQGHKDKAKELK 637
Cdd:COG5112   29 DQIKNDLSTKESQKKLPYDPelpglgqhYCIECARYFITEKALMEHKKGKVHKRRAKELR 88
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 111-402 8.64e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.57  E-value: 8.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  111 PSLTPPQLATPNLQQFFPQATRQSLLGPPPVGVPMNPSQFNLSGRNPQKQARTSSSTTPNRkdsssqtmpvedkSDPPEG 190
Cdd:PHA03247 2708 PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPA-------------PAPPAA 2774

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  191 SEEAAEPRMDTPEDQDLPPCPEDiAKEKRTPAPEPEPCEAselPAKRLRSSEEPTEKEPPgqlqvkaQPQARMTVPKQTQ 270
Cdd:PHA03247 2775 PAAGPPRRLTRPAVASLSESRES-LPSPWDPADPPAAVLA---PAAALPPAASPAGPLPP-------PTSAQPTAPPPPP 2843

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  271 TPDLLPEALEAQVLP----RFQPRVLQVQAQVQSQTQPRIPS-TDTQVQPKLQKQAQTQTSPEHLVLQqkqvqpqlqqea 345
Cdd:PHA03247 2844 GPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRRlARPAVSRSTESFALPPDQPERPPQP------------ 2911

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 196115158  346 EPQKQVQPQVHTQAQPSVQPQEHPPAQVSVQPPEQTHEQPHTQPQVSLLAPEQTPVV 402
Cdd:PHA03247 2912 QAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALV 2968
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 606-630 1.78e-05

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 42.16  E-value: 1.78e-05
                          10        20
                  ....*....|....*....|....*
gi 196115158  606 FCTVCNRYFKTPRKFVEHVKSQGHK 630
Cdd:pfam12171   3 YCVLCDKYFKSENALQNHLKSKKHK 27
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 208-420 4.38e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 47.34  E-value: 4.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  208 PPCPEDIAKEKRTPAPEPE---PCEASELPAKRLRSSEEP-TEKEPPGQLQVKA--------QPQARMTVPKQTQTPDLL 275
Cdd:pfam09770 107 PAARAAQSSAQPPASSLPQyqyASQQSQQPSKPVRTGYEKyKEPEPIPDLQVDAslwgvapkKAAAPAPAPQPAAQPASL 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  276 P---------EALEAQVlpRFQPRVLQVQAQVQSQTQPripstdtqVQPKLQKQAQTQTSPEHLVLQQKQVQPQLQQEAE 346
Cdd:pfam09770 187 PapsrkmmslEEVEAAM--RAQAKKPAQQPAPAPAQPP--------AAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQH 256

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 196115158  347 PQKQVQPQVHtQAQPSVQPqehPPAQVSVQPPEQTHEQPHTQPQVSLLAPEQTPVVVHVCGLEMPPDAVEAGGG 420
Cdd:pfam09770 257 PGQGHPVTIL-QRPQSPQP---DPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQPGVQP 326
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 512-541 5.83e-04

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 38.00  E-value: 5.83e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 196115158   512 QFFCYICKASCSSQQEFQDHMSEPQHQQRL 541
Cdd:smart00451   3 GFYCKLCNVTFTDEISVEAHLKGKKHKKNV 32
UFD2 COG5112
U1-like Zn-finger-containing protein [General function prediction only];
586-637 5.67e-03

U1-like Zn-finger-containing protein [General function prediction only];


Pssm-ID: 227443  Cd Length: 126  Bit Score: 37.75  E-value: 5.67e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158 586 DLIQHRRTQDHKIAKQSLRP--------FCTVCNRYFKTPRKFVEHVKSQGHKDKAKELK 637
Cdd:COG5112   29 DQIKNDLSTKESQKKLPYDPelpglgqhYCIECARYFITEKALMEHKKGKVHKRRAKELR 88
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 111-402 8.64e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.57  E-value: 8.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  111 PSLTPPQLATPNLQQFFPQATRQSLLGPPPVGVPMNPSQFNLSGRNPQKQARTSSSTTPNRkdsssqtmpvedkSDPPEG 190
Cdd:PHA03247 2708 PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPA-------------PAPPAA 2774

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  191 SEEAAEPRMDTPEDQDLPPCPEDiAKEKRTPAPEPEPCEAselPAKRLRSSEEPTEKEPPgqlqvkaQPQARMTVPKQTQ 270
Cdd:PHA03247 2775 PAAGPPRRLTRPAVASLSESRES-LPSPWDPADPPAAVLA---PAAALPPAASPAGPLPP-------PTSAQPTAPPPPP 2843

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  271 TPDLLPEALEAQVLP----RFQPRVLQVQAQVQSQTQPRIPS-TDTQVQPKLQKQAQTQTSPEHLVLQqkqvqpqlqqea 345
Cdd:PHA03247 2844 GPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRRlARPAVSRSTESFALPPDQPERPPQP------------ 2911

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 196115158  346 EPQKQVQPQVHTQAQPSVQPQEHPPAQVSVQPPEQTHEQPHTQPQVSLLAPEQTPVV 402
Cdd:PHA03247 2912 QAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALV 2968
PHA03247 PHA03247
large tegument protein UL36; Provisional
 104-400 2.14e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.41  E-value: 2.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  104 ASPGLAAPSLTPPQLATPNLQQFFPQATRQSLLGPPPVGvPMNPSQFNLSGRnPQKQARTSSSTTPnrkdSSSQTMPVED 183
Cdd:PHA03247 2709 EPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAG-PATPGGPARPAR-PPTTAGPPAPAPP----AAPAAGPPRR 2782

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  184 KSDPPEGSEEAAEPRMDTPEDQDLPPCPEDIAKEKRTPAPEP---EPCEASELPAKRLRSSEEPTEKEPPGQLQVKAQPQ 260
Cdd:PHA03247 2783 LTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPagpLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDV 2862

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  261 ARMTVPKQTQTPDLLPEALEAQVLPRFQ-PRVLQVQAQVQSQtQPRIPSTDTQVQPKLQKQAQTQTSPEhlvlqqkqvqP 339
Cdd:PHA03247 2863 RRRPPSRSPAAKPAAPARPPVRRLARPAvSRSTESFALPPDQ-PERPPQPQAPPPPQPQPQPPPPPQPQ----------P 2931

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 196115158  340 QLQQEAEPQKQVQPQVHTQAQPSVQPQEHPPAQVSVQPPEQTHEQPHT-QPQVSLLAPEQTP 400
Cdd:PHA03247 2932 PPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVpQPAPSREAPASST 2993
PHA03247 PHA03247
large tegument protein UL36; Provisional
 105-418 2.10e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.94  E-value: 2.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  105 SPGLAAPSLTPPQLATPNLQQFFPQATRQSLLGPPPVGVPMNPSQFNLSG----------RNPQKQARTSSSTT-PNRKD 173
Cdd:PHA03247 2608 PRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPApgrvsrprraRRLGRAAQASSPPQrPRRRA 2687

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  174 SSSQTMPVEDKSDPPEGSEEAAEPRMDTPEDQDLPPCPEDIAKEK----RTPAPEPEPcEASELPAKRLRSSEEPTEKEP 249
Cdd:PHA03247 2688 ARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASpalpAAPAPPAVP-AGPATPGGPARPARPPTTAGP 2766

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  250 PGqlqvKAQPQARMTVPKQTQT-PDLLPEALEAQVLPrfQPRVLQVQAQVQSQTQPRIPSTDTQVQPKLQKQAQTQTSPE 328
Cdd:PHA03247 2767 PA----PAPPAAPAAGPPRRLTrPAVASLSESRESLP--SPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP 2840

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  329 HLVLQQKQVQP----------------QLQQEAEPQKQVQPQVHTQAQPSVQPQEHPPAQ--VSVQPPEQTHEQPHTQPQ 390
Cdd:PHA03247 2841 PPPGPPPPSLPlggsvapggdvrrrppSRSPAAKPAAPARPPVRRLARPAVSRSTESFALppDQPERPPQPQAPPPPQPQ 2920

                         330       340
                  ....*....|....*....|....*...
gi 196115158  391 VSLLAPEQTPVVVHVCGLEMPPDAVEAG 418
Cdd:PHA03247 2921 PQPPPPPQPQPPPPPPPRPQPPLAPTTD 2948
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 606-630 1.78e-05

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 42.16  E-value: 1.78e-05
                          10        20
                  ....*....|....*....|....*
gi 196115158  606 FCTVCNRYFKTPRKFVEHVKSQGHK 630
Cdd:pfam12171   3 YCVLCDKYFKSENALQNHLKSKKHK 27
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 104-396 4.13e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 47.39  E-value: 4.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  104 ASPGLAAPSLTPPQLATPNLQ---QFFPQATRqsllgPPPVGVPMNPSQFNLSGRNPQKQARTSSSTTPNRKDSSSQTMP 180
Cdd:PRK10263  577 AAATVAAPVFSLANSGGPRPQvkeGIGPQLPR-----PKRIRVPTRRELASYGIKLPSQRAAEEKAREAQRNQYDSGDQY 651

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  181 VEDKSDPPEGSEEAAE------PRMDTPEDQDLPPCPEDiakekRTPAPEPEPCEASELPAKRLRSSEEPTEKEPPGQLQ 254
Cdd:PRK10263  652 NDDEIDAMQQDELARQfaqtqqQRYGEQYQHDVPVNAED-----ADAAAEAELARQFAQTQQQRYSGEQPAGANPFSLDD 726

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  255 VKAQPQArmtvpkqtqtpDLLPEALEAqvlPRFQPRVLQVQAQVQSQTQPRIPSTDTQVQPKLQKQAQTQTS--PEHLVL 332
Cdd:PRK10263  727 FEFSPMK-----------ALLDDGPHE---PLFTPIVEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPvaPQPQYQ 792

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 196115158  333 QQKQVQPQLQQEAEPQKQVQPQVHTQaqpsvQPQEhppaQVSVQPPEQTHEQPHT-QPQVSLLAP 396
Cdd:PRK10263  793 QPQQPVAPQPQYQQPQQPVAPQPQYQ-----QPQQ----PVAPQPQYQQPQQPVApQPQDTLLHP 848
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 208-420 4.38e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 47.34  E-value: 4.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  208 PPCPEDIAKEKRTPAPEPE---PCEASELPAKRLRSSEEP-TEKEPPGQLQVKA--------QPQARMTVPKQTQTPDLL 275
Cdd:pfam09770 107 PAARAAQSSAQPPASSLPQyqyASQQSQQPSKPVRTGYEKyKEPEPIPDLQVDAslwgvapkKAAAPAPAPQPAAQPASL 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  276 P---------EALEAQVlpRFQPRVLQVQAQVQSQTQPripstdtqVQPKLQKQAQTQTSPEHLVLQQKQVQPQLQQEAE 346
Cdd:pfam09770 187 PapsrkmmslEEVEAAM--RAQAKKPAQQPAPAPAQPP--------AAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQH 256

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 196115158  347 PQKQVQPQVHtQAQPSVQPqehPPAQVSVQPPEQTHEQPHTQPQVSLLAPEQTPVVVHVCGLEMPPDAVEAGGG 420
Cdd:pfam09770 257 PGQGHPVTIL-QRPQSPQP---DPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQPGVQP 326
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 158-400 8.93e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 46.30  E-value: 8.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  158 QKQARTSSSTTPNRKDSS-SQTMPVEDKSDPPEGSEEAAEPRmdtPEDQDLPPCPEDIAKEKRTPAPEPEPCEASELPAK 236
Cdd:pfam03154  83 QREKGASDTEEPERATAKkSKTQEISRPNSPSEGEGESSDGR---SVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSD 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  237 RLRSSEEPTEKEPPGQLQVKAQPQARMTVPKQTQTPDLLPEALEAQVLPRFQPRVLQVQAQVQSQTQP------------ 304
Cdd:pfam03154 160 SSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPhtliqqtptlhp 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  305 -RIPSTDTQVQPKLQKQAQTQTSPEHLVLQQ---KQVQPQLQQEAEP---QKQVQPQVHTQAQPSVQPQEHPPAQVSVqp 377
Cdd:pfam03154 240 qRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSlhgQMPPMPHSLQTGPshmQHPVPPQPFPLTPQSSQSQVPPGPSPAA-- 317

                         250       260
                  ....*....|....*....|...
gi 196115158  378 PEQTHEQPHTQPQVSLLAPEQTP 400
Cdd:pfam03154 318 PGQSQQRIHTPPSQSQLQSQQPP 340
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 244-402 2.65e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 44.69  E-value: 2.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  244 PTEKEPPGQLQVKAQPqarmtVP-KQTQTPDLLPEALEAQVLPRFQPRVLQVQAQVQSQTQPRIPSTDTQVQPKLQKQAQ 322
Cdd:PRK10263  347 ASVDVPPAQPTVAWQP-----VPgPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYY 421

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  323 TQTSPEHLVLQQKQVQPQLQQEAEPQKQVQPQVHTQAQPSVQPQEHPPAQVsvqPPEQTHEQPHTQPQVSLLAPEqtPVV 402
Cdd:PRK10263  422 APAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPA---AQEPLYQQPQPVEQQPVVEPE--PVV 496
PHA03247 PHA03247
large tegument protein UL36; Provisional
 115-511 3.27e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 3.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  115 PPQLATPNLQqffPQATRQSLlgPPPVGVPmnpsqfnlsgrNPQKQARTSSSTTPNRKDSSSQTMPVEDKSDPPEGSEEA 194
Cdd:PHA03247 2551 PPPPLPPAAP---PAAPDRSV--PPPRPAP-----------RPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPP 2614

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  195 AEPRMDTPEDQDLPPCPEDIAKEKRTPAPEPEPceaselPAKRLRSSEEPTEKEPPGQLQVKAQPqARMTVPKQTQTPDL 274
Cdd:PHA03247 2615 SPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVP------PPERPRDDPAPGRVSRPRRARRLGRA-AQASSPPQRPRRRA 2687

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  275 LPEA---LEAQVLPRFQPRvlqvqaQVQSQTQPRIPSTDTQVQPKLQKQAQTQTSPEHLVLQQKQVQPQLQQEAEPQKQV 351
Cdd:PHA03247 2688 ARPTvgsLTSLADPPPPPP------TPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPP 2761

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  352 QPQVHTQAQPSVQPQEHPPAQVSVQPPEQTHEQPHTQPqvSLLAPEQTPVVVHVCGLEMPPDAVEAGGGMEKTLPEPVGT 431
Cdd:PHA03247 2762 TTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLP--SPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAP 2839

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  432 QVSMEEIQNESACGLDVGECENRAREMPgvwgaggslkvtilqssdSRAFSTVPLTPvPRPSDSVSSTPAATSTPSKQAL 511
Cdd:PHA03247 2840 PPPPGPPPPSLPLGGSVAPGGDVRRRPP------------------SRSPAAKPAAP-ARPPVRRLARPAVSRSTESFAL 2900
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 512-541 5.83e-04

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 38.00  E-value: 5.83e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 196115158   512 QFFCYICKASCSSQQEFQDHMSEPQHQQRL 541
Cdd:smart00451   3 GFYCKLCNVTFTDEISVEAHLKGKKHKKNV 32
PRK10927 PRK10927
cell division protein FtsN;
234-400 1.75e-03

cell division protein FtsN;


Pssm-ID: 236797 [Multi-domain]  Cd Length: 319  Bit Score: 41.20  E-value: 1.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158 234 PAKRLRSSEEPTEKEPpgQLQVKAQPQARMTVPKQTQtpdLLPEalEAQVLPRFQPRVLQVQAQVQSQtqPRIPSTDTQV 313
Cdd:PRK10927  79 PEERWRYIKELESRQP--GVRAPTEPSAGGEVKTPEQ---LTPE--QRQLLEQMQADMRQQPTQLVEV--PWNEQTPEQR 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158 314 QPKLQKQAQTQTSPEHLVLQQKQVQPQLQQEAEPQKQVQPQVHTQAQPSVQPQEHPPAQVSVQPPEQTHEQPHTQPQVSL 393
Cdd:PRK10927 150 QQTLQRQRQAQQLAEQQRLAQQSRTTEQSWQQQTRTSQAAPVQAQPRQSKPASTQQPYQDLLQTPAHTTAQSKPQQAAPV 229


                 ....*..
gi 196115158 394 LAPEQTP 400
Cdd:PRK10927 230 TRAADAP 236
PRK14960 PRK14960
DNA polymerase III subunit gamma/tau;
141-326 2.47e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237868 [Multi-domain]  Cd Length: 702  Bit Score: 41.57  E-value: 2.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158 141 VGVPMNPSQFNLSGRNPQKQARTSSSttpnrkdSSSQTMPVEDKSDPP-EGSEEAAEPRMDTPedqdlpPCPEDIAKEKR 219
Cdd:PRK14960 368 VSEPVQQNGQAEVGLNSQAQTAQEIT-------PVSAVQPVEVISQPAmVEPEPEPEPEPEPE------PEPEPEPEPEP 434

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158 220 TPAPEPEPCEASELPAKRLRSSEEPTEKEPPGQLQVKAQPQARMTVPKQTQTP-DLLPEALEAQVLPRF--QPRVLQVQA 296
Cdd:PRK14960 435 EPEPEPEPQPNQDLMVFDPNHHELIGLESAVVQETVSVLEEDFIPVPEQKLVQvQAETQVKQIEPEPAStaEPIGLFEAS 514

                        170       180       190
                 ....*....|....*....|....*....|
gi 196115158 297 QVQSQTQPRIPSTDTQVQPKLQKQAQTQTS 326
Cdd:PRK14960 515 SAEFSLAQDTSAYDLVSEPVIEQQSLVQAE 544
rne PRK10811
ribonuclease E; Reviewed
 201-420 3.26e-03

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 41.18  E-value: 3.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  201 TPEDQDLPPCPEDIAKEKRTPAPEPEPCEASELPAKRLRSSEEPTEKEPPgqlQVKAQPQARMTVPKQTQTPDLlpeale 280
Cdd:PRK10811  849 RPQDVQVEEQREAEEVQVQPVVAEVPVAAAVEPVVSAPVVEAVAEVVEEP---VVVAEPQPEEVVVVETTHPEV------ 919

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  281 aqvlprfqprvlqVQAQVQSQTQPRIPSTDTQVQPKLQKQAQTQTSPEHLVLQQKQVQPQLQQEAEPQKQVQPQVHTQAQ 360
Cdd:PRK10811  920 -------------IAAPVTEQPQVITESDVAVAQEVAEHAEPVVEPQDETADIEEAAETAEVVVAEPEVVAQPAAPVVAE 986

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 196115158  361 PSVQPQEHPPAQVSVQPP---EQTHEQPH-TQPQVSLLAPEQTPVVVHVCGLEMPPDAVEAGGG 420
Cdd:PRK10811  987 VAAEVETVTAVEPEVAPAqvpEATVEHNHaTAPMTRAPAPEYVPEAPRHSDWQRPTFAFEGKGA 1050
PRK12757 PRK12757
cell division protein FtsN; Provisional
 296-401 3.99e-03

cell division protein FtsN; Provisional


Pssm-ID: 237191 [Multi-domain]  Cd Length: 256  Bit Score: 40.03  E-value: 3.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158 296 AQVQSQTQpripSTDTQVQPKLQKQAQTQTSPEHLVLQQKQVQPQLQQEAEPQKQVQPQVHTQAQPSVQPQEHPPAQVSV 375
Cdd:PRK12757  72 GEVNSPTQ----LTDEQRQLLEQMQADMRQQPTQLSEVPYNEQTPQVPRSTVQIQQQAQQQQPPATTAQPQPVTPPRQTT 147

                         90       100
                 ....*....|....*....|....*.
gi 196115158 376 QPPEQTHEQPHTQPQvslLAPEQTPV 401
Cdd:PRK12757 148 APVQPQTPAPVRTQP---AAPVTQAV 170
PRK10927 PRK10927
cell division protein FtsN;
221-384 4.13e-03

cell division protein FtsN;


Pssm-ID: 236797 [Multi-domain]  Cd Length: 319  Bit Score: 40.05  E-value: 4.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158 221 PAPEPEPCEASELPAKR--LRSSEEPT---EKEPPGQL-----QVKAQPQARMTvpkqtQTPDLLPEALEAQVLPRFQPR 290
Cdd:PRK10927  77 PKPEERWRYIKELESRQpgVRAPTEPSaggEVKTPEQLtpeqrQLLEQMQADMR-----QQPTQLVEVPWNEQTPEQRQQ 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158 291 VLQVQAQVQSQTQPRiPSTDTQVQPKLQKQAQTQTSpehlVLQQKQVQPQLQQEAEPQKQ----VQPQVHTQAQPsvQPQ 366
Cdd:PRK10927 152 TLQRQRQAQQLAEQQ-RLAQQSRTTEQSWQQQTRTS----QAAPVQAQPRQSKPASTQQPyqdlLQTPAHTTAQS--KPQ 224

                        170
                 ....*....|....*...
gi 196115158 367 EHPPAQVSVQPPEQTHEQ 384
Cdd:PRK10927 225 QAAPVTRAADAPKPTAEK 242
UFD2 COG5112
U1-like Zn-finger-containing protein [General function prediction only];
586-637 5.67e-03

U1-like Zn-finger-containing protein [General function prediction only];


Pssm-ID: 227443  Cd Length: 126  Bit Score: 37.75  E-value: 5.67e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158 586 DLIQHRRTQDHKIAKQSLRP--------FCTVCNRYFKTPRKFVEHVKSQGHKDKAKELK 637
Cdd:COG5112   29 DQIKNDLSTKESQKKLPYDPelpglgqhYCIECARYFITEKALMEHKKGKVHKRRAKELR 88
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 158-401 6.43e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.14  E-value: 6.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  158 QKQARTSSSTTPNRKDSSSQTMPVEDKSDPPEGSEE--AAEPRMDTPEDQ--DLPPCPEDIAKEKRTPAPEPEPCEASEL 233
Cdd:pfam03154 105 QEISRPNSPSEGEGESSDGRSVNDEGSSDPKDIDQDnrSTSPSIPSPQDNesDSDSSAQQQILQTQPPVLQAQSGAASPP 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  234 PAKRLRSSEEPTEKEPPGQLQVKAQPQARMTVPKQTQTPDLLPEALEAQVLPRFQPRVLQVQAQVQSQTQPRIPST---D 310
Cdd:pfam03154 185 SPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQvspQ 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158  311 TQVQPKLQKQAQT-----QTSPEHLVLQQKQVQPQLQQEAEpQKQVQPQVHTQAQ-PSVQPQEHPPAQVSV---QPPEQT 381
Cdd:pfam03154 265 PLPQPSLHGQMPPmphslQTGPSHMQHPVPPQPFPLTPQSS-QSQVPPGPSPAAPgQSQQRIHTPPSQSQLqsqQPPREQ 343

                         250       260
                  ....*....|....*....|
gi 196115158  382 HEQPHTQPQVSLLAPEQTPV 401
Cdd:pfam03154 344 PLPPAPLSMPHIKPPPTTPI 363
PRK12757 PRK12757
cell division protein FtsN; Provisional
 299-388 6.99e-03

cell division protein FtsN; Provisional


Pssm-ID: 237191 [Multi-domain]  Cd Length: 256  Bit Score: 39.26  E-value: 6.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196115158 299 QSQTQPRIPSTDTQVQPKLQKQAQTQTSPehlvlqqkqvqpqlQQEAEPQKQVQPQVHTQAQPSVQPQEHPPAQVSVQPP 378
Cdd:PRK12757 108 NEQTPQVPRSTVQIQQQAQQQQPPATTAQ--------------PQPVTPPRQTTAPVQPQTPAPVRTQPAAPVTQAVEAP 173

                         90
                 ....*....|
gi 196115158 379 EQTHEQPHTQ 388
Cdd:PRK12757 174 KVEAEKEKEQ 183
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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