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Conserved domains on  [gi|189217718|ref|NP_001121300|]
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N-lysine methyltransferase KMT5A-A [Xenopus laevis]

Protein Classification

SET domain-containing protein( domain architecture ID 14410543)

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain-containing protein may function as a protein-lysine N-methyltransferase, catalyzing the S-adenosyl-L-methionine (SAM)-dependent methylation at specific lysine residues of target proteins such as histones; similar to vertebrate N-lysine methyltransferase KMT5A that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET_SETD8 cd10528
SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2. ...
 183-322 8.13e-87

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2.1.1.43; also termed N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7 or PR/SET07) is a nucleosomal histone-lysine N-methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). It plays a central role in the silencing of euchromatic genes.


:

Pssm-ID: 380926 [Multi-domain]  Cd Length: 141  Bit Score: 257.12  E-value: 8.13e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 183 SEEKKRIDELIQTGKEEGIKMHMITGKGRGVIATRDFQRGEFVVEYHGDLIEITDAKRREASYAQDSATGCYMYYFQYLN 262
Cdd:cd10528    1 KEKKKEIEELILSGKEEGLKVIEIDGKGRGVIATRPFEKGDFVVEYHGDLITITEAKKREALYAKDPSTGCYMYYFQYKG 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 189217718 263 TSYCIDATRETGRLGRLINHSK-SGNCHTKLHNINNVPHLILVASRDINVGEELLYDYGDR 322
Cdd:cd10528   81 KTYCVDATKESGRLGRLINHSKkKPNLKTKLLVIDGVPHLILVAKRDIKPGEELLYDYGDR 141
 
Name Accession Description Interval E-value
SET_SETD8 cd10528
SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2. ...
 183-322 8.13e-87

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2.1.1.43; also termed N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7 or PR/SET07) is a nucleosomal histone-lysine N-methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). It plays a central role in the silencing of euchromatic genes.


Pssm-ID: 380926 [Multi-domain]  Cd Length: 141  Bit Score: 257.12  E-value: 8.13e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 183 SEEKKRIDELIQTGKEEGIKMHMITGKGRGVIATRDFQRGEFVVEYHGDLIEITDAKRREASYAQDSATGCYMYYFQYLN 262
Cdd:cd10528    1 KEKKKEIEELILSGKEEGLKVIEIDGKGRGVIATRPFEKGDFVVEYHGDLITITEAKKREALYAKDPSTGCYMYYFQYKG 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 189217718 263 TSYCIDATRETGRLGRLINHSK-SGNCHTKLHNINNVPHLILVASRDINVGEELLYDYGDR 322
Cdd:cd10528   81 KTYCVDATKESGRLGRLINHSKkKPNLKTKLLVIDGVPHLILVAKRDIKPGEELLYDYGDR 141
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 208-325 1.06e-30

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 112.81  E-value: 1.06e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718   208 GKGRGVIATRDFQRGEFVVEYHGDLIEITDAKRREASYAQDSATGCYMYYfqyLNTSYCIDATReTGRLGRLINHSKSGN 287
Cdd:smart00317  10 GKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAYDTDGAKAFYLFD---IDSDLCIDARR-KGNLARFINHSCEPN 85

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 189217718   288 CHTKLHNINNVPHLILVASRDINVGEELLYDYGDRRKS 325
Cdd:smart00317  86 CELLFVEVNGDDRIVIFALRDIKPGEELTIDYGSDYAN 123
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 210-320 2.35e-30

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 111.46  E-value: 2.35e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718  210 GRGVIATRDFQRGEFVVEYHG-DLIEITDAKRREASYAQDSATGCYMYYFQYLNT--SYCIDATRE-TGRLGRLINHSKS 285
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEvLLITKEEADKRELLYYDKLELRLWGPYLFTLDEdsEYCIDARALyYGNWARFINHSCD 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 189217718  286 GNCHTKLHNINNVPHLILVASRDINVGEELLYDYG 320
Cdd:pfam00856  81 PNCEVRVVYVNGGPRIVIFALRDIKPGEELTIDYG 115
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
208-321 1.94e-21

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 88.48  E-value: 1.94e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 208 GKGRGVIATRDFQRGEFVVEYHGDLIEITDAKRREasyaqDSATGCYMYYFQYLNTSYcIDATRETGrLGRLINHSKSGN 287
Cdd:COG2940   15 IHGRGVFATRDIPKGTLIGEYPGEVITWAEAERRE-----PHKEPLHTYLFELDDDGV-IDGALGGN-PARFINHSCDPN 87

                         90       100       110
                 ....*....|....*....|....*....|....
gi 189217718 288 CHTKLHNinnvPHLILVASRDINVGEELLYDYGD 321
Cdd:COG2940   88 CEADEED----GRIFIVALRDIAAGEELTYDYGL 117
 
Name Accession Description Interval E-value
SET_SETD8 cd10528
SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2. ...
 183-322 8.13e-87

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2.1.1.43; also termed N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7 or PR/SET07) is a nucleosomal histone-lysine N-methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). It plays a central role in the silencing of euchromatic genes.


Pssm-ID: 380926 [Multi-domain]  Cd Length: 141  Bit Score: 257.12  E-value: 8.13e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 183 SEEKKRIDELIQTGKEEGIKMHMITGKGRGVIATRDFQRGEFVVEYHGDLIEITDAKRREASYAQDSATGCYMYYFQYLN 262
Cdd:cd10528    1 KEKKKEIEELILSGKEEGLKVIEIDGKGRGVIATRPFEKGDFVVEYHGDLITITEAKKREALYAKDPSTGCYMYYFQYKG 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 189217718 263 TSYCIDATRETGRLGRLINHSK-SGNCHTKLHNINNVPHLILVASRDINVGEELLYDYGDR 322
Cdd:cd10528   81 KTYCVDATKESGRLGRLINHSKkKPNLKTKLLVIDGVPHLILVAKRDIKPGEELLYDYGDR 141
SET_SETD1-like cd10518
SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), ...
 210-319 6.65e-31

SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), histone-lysine N-methyltransferases (KMT2A/KMT2B/KMT2C/KMT2D) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A), 1B (SETD1B), as well as histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B), 2C (KMT2C), 2D (KMT2D). These proteins are histone-lysine N-methyltransferases (EC 2.1.1.43) that specifically methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380916  Cd Length: 150  Bit Score: 113.85  E-value: 6.65e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 210 GRGVIATRDFQRGEFVVEYHGDLI--EITDAkrREASYAQDSATGCYMYYfqyLNTSYCIDATReTGRLGRLINHSKSGN 287
Cdd:cd10518   25 GWGLFAKRPIAAGEMVIEYVGEVIrpIVADK--REKRYDEEGGGGTYMFR---IDEDLVIDATK-KGNIARFINHSCDPN 98

                         90       100       110
                 ....*....|....*....|....*....|..
gi 189217718 288 CHTKLHNINNVPHLILVASRDINVGEELLYDY 319
Cdd:cd10518   99 CYAKIITVDGEKHIVIFAKRDIAPGEELTYDY 130
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 208-325 1.06e-30

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 112.81  E-value: 1.06e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718   208 GKGRGVIATRDFQRGEFVVEYHGDLIEITDAKRREASYAQDSATGCYMYYfqyLNTSYCIDATReTGRLGRLINHSKSGN 287
Cdd:smart00317  10 GKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAYDTDGAKAFYLFD---IDSDLCIDARR-KGNLARFINHSCEPN 85

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 189217718   288 CHTKLHNINNVPHLILVASRDINVGEELLYDYGDRRKS 325
Cdd:smart00317  86 CELLFVEVNGDDRIVIFALRDIKPGEELTIDYGSDYAN 123
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 210-320 2.35e-30

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 111.46  E-value: 2.35e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718  210 GRGVIATRDFQRGEFVVEYHG-DLIEITDAKRREASYAQDSATGCYMYYFQYLNT--SYCIDATRE-TGRLGRLINHSKS 285
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEvLLITKEEADKRELLYYDKLELRLWGPYLFTLDEdsEYCIDARALyYGNWARFINHSCD 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 189217718  286 GNCHTKLHNINNVPHLILVASRDINVGEELLYDYG 320
Cdd:pfam00856  81 PNCEVRVVYVNGGPRIVIFALRDIKPGEELTIDYG 115
SET_SETD2-like cd10531
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...
 190-321 6.08e-23

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.


Pssm-ID: 380929  Cd Length: 136  Bit Score: 92.32  E-value: 6.08e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 190 DELIQTGKeegikmhmitgKGRGVIATRDFQRGEFVVEYHGDLIEITDAKRREASYAQDSATGcymYYFQYLNTSYCIDA 269
Cdd:cd10531    2 LELFRTEK-----------KGWGVKAKEDIQKGEFIIEYVGEVIDKKEFKERLDEYEELGKSN---FYILSLSDDVVIDA 67

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 189217718 270 TREtGRLGRLINHSKSGNCHTKLHNINNVPHLILVASRDINVGEELLYDYGD 321
Cdd:cd10531   68 TRK-GNLSRFINHSCEPNCETQKWIVNGEYRIGIFALRDIPAGEELTFDYNF 118
SET_KMT2A_2B cd19170
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), ...
 210-319 3.58e-22

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins; This family includes KMT2A and KMT2B. Both KMT2A (also termed ALL-1 or CXXC7 or MLL or MLL1 or TRX1 or HRX) and KMT2B (also termed MLL4 or TRX2) act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380947 [Multi-domain]  Cd Length: 152  Bit Score: 90.91  E-value: 3.58e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 210 GRGVIATRDFQRGEFVVEYHGDLIEITDAKRREASYaQDSATGCYMYYfqyLNTSYCIDATREtGRLGRLINHSKSGNCH 289
Cdd:cd19170   25 GRGLFCKRNIDAGEMVIEYAGEVIRSVLTDKREKYY-ESKGIGCYMFR---IDDDEVVDATMH-GNAARFINHSCEPNCY 99

                         90       100       110
                 ....*....|....*....|....*....|
gi 189217718 290 TKLHNINNVPHLILVASRDINVGEELLYDY 319
Cdd:cd19170  100 SRVVNIDGKKHIVIFALRRILRGEELTYDY 129
SET_EZH cd10519
SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar ...
 204-321 6.94e-22

SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both, EZH1 and EZH2, can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380917  Cd Length: 117  Bit Score: 88.84  E-value: 6.94e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 204 HMITGK----GRGVIATRDFQRGEFVVEYHGDLIEITDAKRREASYAQDSATgcymYYFQyLNTSYCIDATREtGRLGRL 279
Cdd:cd10519    2 RLLLGKsdvaGWGLFLKEPIKKDEFIGEYTGELISQDEADRRGKIYDKYNSS----YLFN-LNDQFVVDATRK-GNKIRF 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 189217718 280 INHSKSGNCHTKLHNINNVPHLILVASRDINVGEELLYDYGD 321
Cdd:cd10519   76 ANHSSNPNCYAKVMMVNGDHRIGIFAKRDIEAGEELFFDYGY 117
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
208-321 1.94e-21

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 88.48  E-value: 1.94e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 208 GKGRGVIATRDFQRGEFVVEYHGDLIEITDAKRREasyaqDSATGCYMYYFQYLNTSYcIDATRETGrLGRLINHSKSGN 287
Cdd:COG2940   15 IHGRGVFATRDIPKGTLIGEYPGEVITWAEAERRE-----PHKEPLHTYLFELDDDGV-IDGALGGN-PARFINHSCDPN 87

                         90       100       110
                 ....*....|....*....|....*....|....
gi 189217718 288 CHTKLHNinnvPHLILVASRDINVGEELLYDYGD 321
Cdd:COG2940   88 CEADEED----GRIFIVALRDIAAGEELTYDYGL 117
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 200-319 1.02e-20

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 86.58  E-value: 1.02e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 200 GIKMHMITGKGRGVIATRDFQRGEFVVEYHGDLIEITDAKRR-EASYAQDSAtgcymYYFQYLNTSYCIDATReTGRLGR 278
Cdd:cd19174    1 GLERFRTEDKGWGVRTKEPIKAGQFIIEYVGEVVSEQEFRRRmIEQYHNHSH-----HYCLNLDSGMVIDGYR-MGNEAR 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 189217718 279 LINHSKSGNCHTKLHNINNVPHLILVASRDINVGEELLYDY 319
Cdd:cd19174   75 FVNHSCDPNCEMQKWSVNGVYRIGLFALKDIPAGEELTYDY 115
SET_SETD2 cd19172
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...
 191-319 1.23e-20

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.


Pssm-ID: 380949 [Multi-domain]  Cd Length: 142  Bit Score: 86.48  E-value: 1.23e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 191 ELIQTGKeegikmhmitgKGRGVIATRDFQRGEFVVEYHGDLIEITDAKRREASYAQDsatGCYMYYFQYLNTSYCIDAT 270
Cdd:cd19172    5 EVFRTEK-----------KGWGLRAAEDLPKGTFVIEYVGEVLDEKEFKRRMKEYARE---GNRHYYFMALKSDEIIDAT 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 189217718 271 REtGRLGRLINHSKSGNCHTKLHNINNVPHLILVASRDINVGEELLYDY 319
Cdd:cd19172   71 KK-GNLSRFINHSCEPNCETQKWTVNGELRVGFFAKRDIPAGEELTFDY 118
SET_KMT2C_2D cd19171
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), ...
 209-319 2.60e-20

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; This family includes KMT2C and KMT2D. Both, KMT2C (also termed HALR or MLL3) and KMT2D (also termed ALR or MLL2), act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me). They are subunits of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380948 [Multi-domain]  Cd Length: 153  Bit Score: 85.94  E-value: 2.60e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 209 KGRGVIATRDFQRGEFVVEYHGDLIEITDAKRREASYaQDSATGCYMYYfqyLNTSYCIDATrETGRLGRLINHSKSGNC 288
Cdd:cd19171   24 QGLGLYAARDIEKHTMVIEYIGEIIRNEVANRREKIY-ESQNRGIYMFR---IDNDWVIDAT-MTGGPARYINHSCNPNC 98

                         90       100       110
                 ....*....|....*....|....*....|.
gi 189217718 289 HTKLHNINNVPHLILVASRDINVGEELLYDY 319
Cdd:cd19171   99 VAEVVTFDKEKKIIIISNRRIAKGEELTYDY 129
SET_SETD1 cd19169
SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and ...
 212-319 3.85e-18

SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A) and SET domain-containing protein 1B (SETD1B). These proteins are histone-lysine N-methyltransferases that specifically methylate 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated.


Pssm-ID: 380946  Cd Length: 148  Bit Score: 79.69  E-value: 3.85e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 212 GVIATRDFQRGEFVVEYHGDLIEITDAKRREASYAQDSATGCYMYYfqyLNTSYCIDATReTGRLGRLINHSKSGNCHTK 291
Cdd:cd19169   26 GLFALEPIAADEMVIEYVGQVIRQSVADEREKRYEAIGIGSSYLFR---VDDDTIIDATK-CGNLARFINHSCNPNCYAK 101

                         90       100
                 ....*....|....*....|....*...
gi 189217718 292 LHNINNVPHLILVASRDINVGEELLYDY 319
Cdd:cd19169  102 IITVESQKKIVIYSKRPIAVNEEITYDY 129
SET_KMT2A cd19206
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) ...
 210-319 4.64e-18

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) and similar proteins; KMT2A (EC2.1.1.43; also termed lysine N-methyltransferase 2A, ALL-1, CXXC-type zinc finger protein 7 (CXXC7), myeloid/lymphoid or mixed-lineage leukemia (MLL), myeloid/lymphoid or mixed-lineage leukemia protein 1 (MLL1), trithorax-like protein (TRX1), or zinc finger protein HRX) acts as a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac).


Pssm-ID: 380983 [Multi-domain]  Cd Length: 154  Bit Score: 79.68  E-value: 4.64e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 210 GRGVIATRDFQRGEFVVEYHGDLIEITDAKRREaSYAQDSATGCYMYYfqyLNTSYCIDATREtGRLGRLINHSKSGNCH 289
Cdd:cd19206   25 GRGLFCKRNIDAGEMVIEYSGNVIRSILTDKRE-KYYDSKGIGCYMFR---IDDSEVVDATMH-GNAARFINHSCEPNCY 99

                         90       100       110
                 ....*....|....*....|....*....|
gi 189217718 290 TKLHNINNVPHLILVASRDINVGEELLYDY 319
Cdd:cd19206  100 SRVINIDGQKHIVIFAMRKIYRGEELTYDY 129
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 208-320 9.39e-18

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 80.49  E-value: 9.39e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 208 GKGRGVIATRDFQRGEFVVEYHGDLIEITDAKRREASYaqDSATGCY---MYYFQYLNT---SYCIDATrETGRLGRLIN 281
Cdd:cd10538   98 KKGWGVRSLEFIPKGSFVCEYVGEVITTSEADRRGKIY--DKSGGSYlfdLDEFSDSDGdgeELCVDAT-FCGNVSRFIN 174

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 189217718 282 HSKSGNC--------HTKLHninnVPHLILVASRDINVGEELLYDYG 320
Cdd:cd10538  175 HSCDPNLfpfnvvidHDDLR----YPRIALFATRDILPGEELTFDYG 217
SET_NSD cd19173
SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, ...
 208-324 1.24e-17

SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, NSD2, NSD3 and similar proteins; The nuclear receptor-binding SET Domain (NSD) family of histone H3 lysine 36 methyltransferases is comprised of NSD1, NSD2, and NSD3, which are primarily known to be involved in chromatin integrity and gene expression through mono-, di-, or tri-methylating lysine 36 of histone H3 (H3K36), respectively. NSD1 (EC 2.1.1.43; also termed histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B) or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3.


Pssm-ID: 380950 [Multi-domain]  Cd Length: 142  Bit Score: 78.13  E-value: 1.24e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 208 GKGRGVIATRDFQRGEFVVEYHGDLIEITDAKRREASYAQDSATGcymYYFQYLNTSYCIDAtRETGRLGRLINHSKSGN 287
Cdd:cd19173   11 DRGWGLRTKRDIKKGDFVIEYVGELIDEEECRRRLKKAHENNITN---FYMLTLDKDRIIDA-GPKGNLSRFMNHSCQPN 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 189217718 288 CHTKLHNINNVPHLILVASRDINVGEELLYDY-----GDRRK 324
Cdd:cd19173   87 CETQKWTVNGDTRVGLFAVRDIPAGEELTFNYnldclGNEKK 128
SET_EZH-like cd19168
SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb ...
 210-322 1.56e-17

SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb repressive complex 2 (PRC2), and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both EZH1 and EZH2 can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380945  Cd Length: 124  Bit Score: 77.61  E-value: 1.56e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 210 GRGVIATRDFQRGEFVVEYHGDLIEITDAKRREASYAQDSatgcYMYYFQyLNTSYCIDATREtGRLGRLINH----SKS 285
Cdd:cd19168   13 GLGLFAAEDIKEGEFVIEYTGELISHDEGVRREHRRGDVS----YLYLFE-EQEGIWVDAAIY-GNLSRYINHatdkVKT 86

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 189217718 286 GNCHTKLHNINNVPHLILVASRDINVGEELLYDYGDR 322
Cdd:cd19168   87 GNCMPKIMYVNHEWRIKFTAIKDIKIGEELFFNYGDN 123
SET_EHMT cd10543
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 192-322 2.13e-17

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase EHMT1, EHMT2 and similar proteins; This family includes EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380941 [Multi-domain]  Cd Length: 231  Bit Score: 80.08  E-value: 2.13e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 192 LIQTGKEEGIKMHMITGKGRGVIATRDFQRGEFVVEYHGDLIEITDAKRREasyaQDSatgcymYYFQYLNT---SYCID 268
Cdd:cd10543   84 VVQNGIRYRLQLFRTRGMGWGVRALQDIPKGTFVCEYIGELISDSEADSRE----DDS------YLFDLDNKdgeTYCID 153

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 189217718 269 AtRETGRLGRLINHSksgnCHTKL--------HNINNVPHLILVASRDINVGEELLYDYGDR 322
Cdd:cd10543  154 A-RRYGNISRFINHL----CEPNLipvrvfveHQDLRFPRIAFFASRDIKAGEELGFDYGEK 210
SET_EZH2 cd19218
SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43) ...
 200-319 6.66e-16

SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43), also termed lysine N-methyltransferase 6, or ENX-1, or histone-lysine N-methyltransferase EZH2, is a catalytic subunit of the polycomb repressive complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380995  Cd Length: 120  Bit Score: 73.02  E-value: 6.66e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 200 GIKMHMITG----KGRGVIATRDFQRGEFVVEYHGDLIEITDAKRREASYAQdsatgcYMYYFQY-LNTSYCIDATRETG 274
Cdd:cd19218    1 GSKKHLLLApsdvAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDK------YMCSFLFnLNNDFVVDATRKGN 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 189217718 275 RLgRLINHSKSGNCHTKLHNINNVPHLILVASRDINVGEELLYDY 319
Cdd:cd19218   75 KI-RFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDY 118
SET_SETMAR cd10544
SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...
 209-320 7.05e-16

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.


Pssm-ID: 380942 [Multi-domain]  Cd Length: 254  Bit Score: 76.18  E-value: 7.05e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 209 KGRGVIATRDFQRGEFVVEYHGDLIEITDAKRREASyaQDSATGCYMYYF-------QYLNTsyCIDATReTGRLGRLIN 281
Cdd:cd10544  100 KGWGLRTLEFIPKGRFVCEYAGEVIGFEEARRRTKS--QTKGDMNYIIVLrehlssgKVLET--FVDPTY-IGNIGRFLN 174

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 189217718 282 HSKSGNCHTKLHNINN-VPHLILVASRDINVGEELLYDYG 320
Cdd:cd10544  175 HSCEPNLFMVPVRVDSmVPKLALFAARDIVAGEELSFDYS 214
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 208-323 1.12e-15

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 72.37  E-value: 1.12e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 208 GKGRGVIATRDFQRGEFVVEYHGdlIEITDAKRREAS-YAQDSAtgcYMYYFQYLNtsYCIDATREtGRLGRLINHSKSG 286
Cdd:cd10522   12 HNGLGLFAAETIAKGEFVGEYTG--EVLDRWEEDRDSvYHYDPL---YPFDLNGDI--LVIDAGKK-GNLTRFINHSDQP 83

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 189217718 287 NCHTKLHNINNVPHLILVASRDINVGEELLYDYGDRR 323
Cdd:cd10522   84 NLELIVRTLKGEQHIGFVAIRDIKPGEELFISYGPKY 120
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 201-320 1.16e-15

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 70.74  E-value: 1.16e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 201 IKMHMITGKGRGVIATRDFQRGEFVVeyhgdlieitdakrreasyaqdsatgcymyyfqylntsycidatretgrLGRLI 280
Cdd:cd08161    2 IRPSTIPGAGFGLFATRDIPKGEVIG-------------------------------------------------LARFI 32

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 189217718 281 NHSKSGNCHTKLHNINNVPHLILVASRDINVGEELLYDYG 320
Cdd:cd08161   33 NHSCEPNCEFEEVYVGGKPRVFIVALRDIKAGEELTVDYG 72
SET_EZH1 cd19217
SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43) ...
 198-329 1.99e-14

SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43), also termed ENX-2, or histone-lysine N-methyltransferase EZH1, is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380994  Cd Length: 136  Bit Score: 69.33  E-value: 1.99e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 198 EEGIKMHMITG----KGRGVIATRDFQRGEFVVEYHGDLIEITDAKRREASYAQdsatgcYMYYFQY-LNTSYCIDATRE 272
Cdd:cd19217    1 QRGLKKHLLLApsdvAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDK------YMSSFLFnLNNDFVVDATRK 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 189217718 273 TGRLgRLINHSKSGNCHTKLHNINNVPHLILVASRDINVGEELLYDYgdrRKSSIDA 329
Cdd:cd19217   75 GNKI-RFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQQGEELFFDY---RYSQADA 127
SET_ASHR3-like cd19175
SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 ...
 202-319 2.22e-14

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins; This family includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3, also termed protein SET DOMAIN GROUP 4 or protein stamen loss), ASH1 homolog 3 (ASHH3, also termed protein SET DOMAIN GROUP 7) and homolog 4 (ASHH4, also termed protein SET DOMAIN GROUP 24). They all function as histone-lysine N-methyltransferases (EC 2.1.1.43).


Pssm-ID: 380952 [Multi-domain]  Cd Length: 139  Bit Score: 69.37  E-value: 2.22e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 202 KMHMITGK--GRGVIATRDFQRGEFVVEYHGDLIEITDAKRREASYAQDSATGCYMYYfqyLNTSYCIDATREtGRLGRL 279
Cdd:cd19175    1 KMKLVKTEkcGWGLVADEDINAGEFIIEYVGEVIDDKTCEERLWDMKHKGEKNFYMCE---IDKDMVIDATFK-GNLSRF 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 189217718 280 INHSKSGNCHTKLHNINNVPHLILVASRDINVGEELLYDY 319
Cdd:cd19175   77 INHSCDPNCELQKWQVDGETRIGVFAIRDIKKGEELTYDY 116
SET_NSD2 cd19211
SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) ...
 208-319 2.77e-14

SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins; NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-36' (H3K36me) methyltransferase activity. NSD2 has been shown to mediate di- and trimethylation of H3K36 and dimethylation of H4K20 in different systems, and has been characterized as a transcriptional repressor interacting with histone deacetylase HDAC1 and histone demethylase LSD1. NSD2 mediates constitutive NF-kappaB signaling for cancer cell proliferation, survival and tumor growth. It is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumor aggressiveness. WHSC1 is frequently deleted in Wolf-Hirschhorn syndrome (WHS).


Pssm-ID: 380988 [Multi-domain]  Cd Length: 142  Bit Score: 69.25  E-value: 2.77e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 208 GKGRGVIATRDFQRGEFVVEYHGDLIEITDAKRREASYAQDSATGCYMYyfqYLNTSYCIDATREtGRLGRLINHSKSGN 287
Cdd:cd19211   11 GKGWGLIAKRDIKKGEFVNEYVGELIDEEECMARIKHAHENDITHFYML---TIDKDRIIDAGPK-GNYSRFMNHSCQPN 86

                         90       100       110
                 ....*....|....*....|....*....|..
gi 189217718 288 CHTKLHNINNVPHLILVASRDINVGEELLYDY 319
Cdd:cd19211   87 CETQKWTVNGDTRVGLFAVCDIPAGTELTFNY 118
SET_EHMT1 cd10535
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 190-322 9.38e-14

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins; EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, or lysine N-methyltransferase 1D (KMT1D)) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380933 [Multi-domain]  Cd Length: 231  Bit Score: 69.58  E-value: 9.38e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 190 DELIQTGKEEGIKMHMITGKGRGVIATRDFQRGEFVVEYHGDLIEITDAKRREasyaQDSatgcymYYFQYLNTS---YC 266
Cdd:cd10535   82 NRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVRE----EDS------YLFDLDNKDgevYC 151

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 189217718 267 IDAtRETGRLGRLINHsksgNCHTKL--------HNINNVPHLILVASRDINVGEELLYDYGDR 322
Cdd:cd10535  152 IDA-RFYGNVSRFINH----HCEPNLvpvrvfmaHQDLRFPRIAFFSTRLIEAGEQLGFDYGER 210
SET_EHMT2 cd10533
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 190-322 1.25e-13

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins; EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C (KMT1C), or protein G9a) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380931 [Multi-domain]  Cd Length: 239  Bit Score: 69.28  E-value: 1.25e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 190 DELIQTGKEEGIKMHMITGKGRGVIATRDFQRGEFVVEYHGDLIEITDAKRREasyaQDSatgcymYYFQYLNTS---YC 266
Cdd:cd10533   82 NRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVRE----DDS------YLFDLDNKDgevYC 151

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 267 IDAtRETGRLGRLINHSKSGNCHT----KLHNINNVPHLILVASRDINVGEELLYDYGDR 322
Cdd:cd10533  152 IDA-RYYGNISRFINHLCDPNIIPvrvfMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDR 210
SET_KMT2B cd19207
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) ...
 188-319 1.70e-13

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) and similar proteins; KMT2B (EC2.1.1.43; also termed lysine N-methyltransferase 2B, myeloid/lymphoid or mixed-lineage leukemia protein 4 (MLL2/MLL4), trithorax homolog 2 (TRX2), or WW domain-binding protein 7 (WBP-7)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that precedes resumption of meiosis, oocyte survival and normal zygotic genome activation.


Pssm-ID: 380984 [Multi-domain]  Cd Length: 154  Bit Score: 67.36  E-value: 1.70e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 188 RIDELIQTGKEeGIKMHMITGKGRGVIATRDFQRGEFVVEYHGDLIEITDAKRREASYaQDSATGCYMYYFQYLNTsycI 267
Cdd:cd19207    4 RFRHLKKTSKE-AVGVYRSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFY-DSKGIGCYMFRIDDFDV---V 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 189217718 268 DATREtGRLGRLINHSKSGNCHTKLHNINNVPHLILVASRDINVGEELLYDY 319
Cdd:cd19207   79 DATMH-GNAARFINHSCEPNCYSRVIHVEGQKHIVIFALRKIYRGEELTYDY 129
SET_SUV39H cd10542
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 208-319 3.96e-13

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homologs, SUV39H1, SUV39H2 and similar proteins; This family includes SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. Also included are Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (SUV39H homolog) and Neurospora crassa DIM-5, both of which also methylate 'Lys-9' of histone H3.


Pssm-ID: 380940 [Multi-domain]  Cd Length: 245  Bit Score: 68.09  E-value: 3.96e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 208 GKGRGVIATRDFQRGEFVVEYHGDLIEITDAKRREASYAQDSATgcYMY---YFQYLNtSYCIDATReTGRLGRLINHSK 284
Cdd:cd10542   97 GRGWGVKTLEDIKKGTFVMEYVGEIITSEEAERRGKIYDANGRT--YLFdldYNDDDC-EYTVDAAY-YGNISHFINHSC 172

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 189217718 285 SGNCHTKLHNINNV----PHLILVASRDINVGEELLYDY 319
Cdd:cd10542  173 DPNLAVYAVWINHLdprlPRIAFFAKRDIKAGEELTFDY 211
SET_SET1 cd20072
SET domain (including post-SET domain) found in catalytic component of the Saccharomyces ...
 212-319 6.38e-13

SET domain (including post-SET domain) found in catalytic component of the Saccharomyces cerevisiae COMPASS complex and similar proteins; The family contains mostly fungal SET domains, including SET1 found in the catalytic component of the Saccharomyces cerevisiae COMPASS (complex of proteins associated with Set1). SET1 is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex. The activity of this catalytic domain is established through forming a complex with a set of core proteins; it is extensively contacted by Cps60 (Bre2), Cps50 (Swd1), and Cps30 (Swd3).


Pssm-ID: 380998  Cd Length: 148  Bit Score: 65.52  E-value: 6.38e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 212 GVIATRDFQRGEFVVEYHGDLIEITDAKRREASYAQDsatGCYMYYFQYLNTSYCIDATREtGRLGRLINHSKSGNCHTK 291
Cdd:cd20072   26 GLYAMENISAKDMVIEYVGEVIRQQVADEREKRYLRQ---GIGSSYLFRIDDDTVVDATKK-GNIARFINHCCDPNCTAK 101

                         90       100
                 ....*....|....*....|....*...
gi 189217718 292 LHNINNVPHLILVASRDINVGEELLYDY 319
Cdd:cd20072  102 IIKVEGEKRIVIYAKRDIAAGEELTYDY 129
SET_KMT2D cd19209
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) ...
 209-319 1.03e-12

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins; KMT2D (EC2.1.1.43; also termed lysine N-methyltransferase 2D, ALL1-related protein (ALR), or myeloid/lymphoid or mixed-lineage leukemia protein 2 (MLL2)), acts as histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. KMT2D is a subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380986 [Multi-domain]  Cd Length: 155  Bit Score: 65.10  E-value: 1.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 209 KGRGVIATRDFQRGEFVVEYHGDLIEITDAKRREASYaQDSATGCYMYYfqyLNTSYCIDATReTGRLGRLINHSKSGNC 288
Cdd:cd19209   26 QGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIY-EEQNRGIYMFR---INNEHVIDATL-TGGPARYINHSCAPNC 100

                         90       100       110
                 ....*....|....*....|....*....|.
gi 189217718 289 HTKLHNINNVPHLILVASRDINVGEELLYDY 319
Cdd:cd19209  101 VAEVVTFDKEDKIIIISSRRIPKGEELTYDY 131
SET_KMT2C cd19208
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) ...
 209-319 2.02e-12

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) and similar proteins; KMT2C (EC2.1.1.43; also termed lysine N-methyltransferase 2C, homologous to ALR protein (HALR) myeloid/lymphoid, or mixed-lineage leukemia protein 3 (MLL3)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me) and may be involved in leukemogenesis and developmental disorder. KMT2C is a catalytic subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. Overexpression of KMT2C is associated with estrogen receptor-positive breast cancer; KMT2C mediates the estrogen dependence of breast cancer through regulation of estrogen receptor alpha (ERalpha) enhancer function. KMT2C is frequently mutated in certain populations with diffuse-type gastric adenocarcinomas (DGA); its loss promotes epithelial-to-mesenchymal transition (EMT) and is associated with worse overall survival.


Pssm-ID: 380985 [Multi-domain]  Cd Length: 154  Bit Score: 64.26  E-value: 2.02e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 209 KGRGVIATRDFQRGEFVVEYHGDLIEITDAKRREASYaQDSATGCYMYYfqyLNTSYCIDATReTGRLGRLINHSKSGNC 288
Cdd:cd19208   25 QGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLY-ESQNRGVYMFR---IDNDHVIDATL-TGGPARYINHSCAPNC 99

                         90       100       110
                 ....*....|....*....|....*....|.
gi 189217718 289 HTKLHNINNVPHLILVASRDINVGEELLYDY 319
Cdd:cd19208  100 VAEVVTFEKGHKIIISSSRRIQKGEELCYDY 130
SET_SUV39H2 cd10532
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 208-334 2.70e-12

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins; SUV39H2 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B (KMT1B), or Su(var)3-9 homolog 2) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380930 [Multi-domain]  Cd Length: 243  Bit Score: 65.68  E-value: 2.70e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 208 GKGRGVIATRDFQRGEFVVEYHGDLIEITDAKRREASYaqDSATGCYMYYFQYLNTSYCIDATReTGRLGRLINHSKSGN 287
Cdd:cd10532   94 GRGWGVKTLQKIKKNSFVMEYVGEVITSEEAERRGQFY--DSKGITYLFDLDYESDEFTVDAAR-YGNVSHFVNHSCDPN 170

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 189217718 288 CHTKLHNINN----VPHLILVASRDINVGEELLYDY-----GDRRKSSIDAHPWLK 334
Cdd:cd10532  171 LQVFNVFIDNldtrLPRIALFSTRTIKAGEELTFDYqmkgsGDLSSDSIDNSPAKK 226
SET_SpSet7-like cd10540
SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...
 206-322 1.87e-11

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).


Pssm-ID: 380938  Cd Length: 112  Bit Score: 60.34  E-value: 1.87e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 206 ITGKGRGVIATRDFQRGEfvveyhgdLIEITDAKRREASYAQDSATGC-YMYYFQYLNTSYCIDAtretGrLGRLINHSK 284
Cdd:cd10540    7 STLKGRGVFATRPIKKGE--------VIEEAPVIVLPKEEYQHLCKTVlDHYVFSWGDGCLALAL----G-YGSMFNHSY 73

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 189217718 285 SGNCHTKLHNINNVphLILVASRDINVGEELLYDYGDR 322
Cdd:cd10540   74 TPNAEYEIDFENQT--IVFYALRDIEAGEELTINYGDD 109
SET_SUV39H1 cd10525
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 208-319 3.08e-11

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 1 (SUV39H1) and similar proteins; SUV39H1 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A (KMT1A), position-effect variegation 3-9 homolog (SUV39H), or Su(var)3-9 homolog 1) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380923 [Multi-domain]  Cd Length: 255  Bit Score: 62.60  E-value: 3.08e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 208 GKGRGVIATRDFQRGEFVVEYHGDLIEITDAKRREASYAQDSATgcYMYYFQYLNTSYCIDATReTGRLGRLINHSKSGN 287
Cdd:cd10525   96 GRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGAT--YLFDLDYVEDVYTVDAAY-YGNISHFVNHSCDPN 172

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 189217718 288 CHTKLHNINNV----PHLILVASRDINVGEELLYDY 319
Cdd:cd10525  173 LQVYNVFIDNLderlPRIALFATRTIRAGEELTFDY 208
SET_SETD1A cd19204
SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and ...
 212-319 3.78e-11

SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and similar proteins; SETD1A (EC2.1.1.43), also termed lysine N-methyltransferase 2F, or Set1/Ash2 histone methyltransferase complex subunit SET1, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Human SET domain containing protein 1A (hSETD1A) expression occurs at a high rate in hepatocellular carcinoma patients and controls tumor metastasis in breast cancer by activating MMP expression.


Pssm-ID: 380981 [Multi-domain]  Cd Length: 153  Bit Score: 60.42  E-value: 3.78e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 212 GVIATRDFQRGEFVVEYHGDLIEITDAKRREASYAQDSATGCYMYYfqyLNTSYCIDATReTGRLGRLINHSKSGNCHTK 291
Cdd:cd19204   27 GLFAMEPIAADEMVIEYVGQNIRQVVADMREKRYVQEGIGSSYLFR---VDHDTIIDATK-CGNLARFINHCCTPNCYAK 102

                         90       100
                 ....*....|....*....|....*...
gi 189217718 292 LHNINNVPHLILVASRDINVGEELLYDY 319
Cdd:cd19204  103 VITIESQKKIVIYSKQPIGVNEEITYDY 130
SET_NSD3 cd19212
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 208-319 1.08e-10

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 3 (NSD3) and similar proteins; NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. NSD3 is amplified and overexpressed in multiple cancer types, including acute myeloid leukemia (AML), breast, lung, pancreatic and bladder cancers, as well as squamous cell carcinoma of the head and neck (SCCHN). NSD3 contributes to tumorigenesis by interacting with bromodomain-containing protein 4 (BRD4), the bromodomain and extraterminal (BET) protein, which is a potential therapeutic target in acute myeloid leukemia (AML). NSD3 is amplified in primary tumors and cell lines from breast carcinoma, and can promote the cell viability of small-cell lung cancer and pancreatic ductal adenocarcinoma. High NSD3 expression is implicated in poor grade and heavy smoking history in SCCHN. Thus, NSD3 may serve as a potential druggable target for selective cancer therapy.


Pssm-ID: 380989 [Multi-domain]  Cd Length: 142  Bit Score: 58.78  E-value: 1.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 208 GKGRGVIATRDFQRGEFVVEYHGDLIEITDAKRREASYAQDSATGCYMYYfqyLNTSYCIDATREtGRLGRLINHSKSGN 287
Cdd:cd19212   11 RRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLT---VTKDRIIDAGPK-GNYSRFMNHSCNPN 86

                         90       100       110
                 ....*....|....*....|....*....|..
gi 189217718 288 CHTKLHNINNVPHLILVASRDINVGEELLYDY 319
Cdd:cd19212   87 CETQKWTVNGDVRVGLFALCDIPAGMELTFNY 118
SET_NSD1 cd19210
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 208-319 5.14e-10

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins; NSD1 (EC 2.1.1.43; also termed Histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD1 is altered in approximately 10% of head and neck cancer patients with 55% decrease in risk of death in NSD1-mutated versus non-mutated patients; its disruption promotes favorable chemotherapeutic responses linked to hypomethylation.


Pssm-ID: 380987 [Multi-domain]  Cd Length: 142  Bit Score: 56.86  E-value: 5.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 208 GKGRGVIATRDFQRGEFVVEYHGDLIEITDAKRReASYAQDSATGcyMYYFQYLNTSYCIDATREtGRLGRLINHSKSGN 287
Cdd:cd19210   11 GRGWGLRCKTDIKKGEFVNEYVGELIDEEECRAR-IRYAQEHDIT--NFYMLTLDKDRIIDAGPK-GNYARFMNHCCQPN 86

                         90       100       110
                 ....*....|....*....|....*....|..
gi 189217718 288 CHTKLHNINNVPHLILVASRDINVGEELLYDY 319
Cdd:cd19210   87 CETQKWTVNGDTRVGLFALCDIKAGTELTFNY 118
SET_SETD1B cd19205
SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and ...
 212-319 5.96e-10

SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and similar proteins; SETD1B (EC2.1.1.43), also termed lysine N-methyltransferase 2G, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Loss of SETD1B occurs in up to half the gastric and colorectal cancers, most commonly via SETD1B mutations, while de novo variants in SETD1B are associated with intellectual disability, epilepsy and autism.


Pssm-ID: 380982 [Multi-domain]  Cd Length: 153  Bit Score: 56.99  E-value: 5.96e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 212 GVIATRDFQRGEFVVEYHGDLIEITDAKRREASYAQDSATGCYMYYFQYlntSYCIDATReTGRLGRLINHSKSGNCHTK 291
Cdd:cd19205   27 GLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYEDEGIGSSYMFRVDH---DTIIDATK-CGNFARFINHSCNPNCYAK 102

                         90       100
                 ....*....|....*....|....*...
gi 189217718 292 LHNINNVPHLILVASRDINVGEELLYDY 319
Cdd:cd19205  103 VITVESQKKIVIYSKQHINVNEEITYDY 130
SET_SETD5-like cd10529
SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine ...
 211-315 8.05e-10

SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. KMT2E (also termed inactive lysine N-methyltransferase 2E or myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. The family also includes Saccharomyces cerevisiae SET domain-containing proteins, SET3 and SET4, and Schizosaccharomyces pombe SET3. Most of these family members contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380927  Cd Length: 127  Bit Score: 56.13  E-value: 8.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 211 RGVIATRDFQRGEFVVEYHGDLIEITDAKRREASYaqdSATGCYMYYFQ-YLNTSYCIDAtRETGRLGRLINHSKSGNCH 289
Cdd:cd10529   17 KGLVATEDISPGEPILEYKGEVSLRSEFKEDNGFF---KRPSPFVFFYDgFEGLPLCVDA-RKYGNEARFIRRSCRPNAE 92

                         90       100
                 ....*....|....*....|....*....
gi 189217718 290 tkLH---NINNVPHLILVASRDINVGEEL 315
Cdd:cd10529   93 --LRhvvVSNGELRLFIFALKDIRKGTEI 119
SET_SUV39H_Clr4-like cd20073
SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 ...
 190-322 1.68e-09

SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 methyltransferase Clr4, and similar proteins; This subfamily contains fission yeast Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (also known as Suv39h), the sole homolog of the mammalian SUV39H1 and SUV39H2 enzymes, that has a critical role in preventing aberrant heterochromatin formation. It is known to di- and tri-methylate Lys-9 of histone H3, a central heterochromatic histone modification, with its specificity profile most similar to that of the human SUV39H2 homolog.


Pssm-ID: 380999 [Multi-domain]  Cd Length: 259  Bit Score: 57.58  E-value: 1.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 190 DELIQTGKEEGIKMHMITGKGRGVIATRDFQRGEFVVEYHGDLIEITDAKRREASYAQDSATgcYMYYFQY----LNTSY 265
Cdd:cd20073   84 NRVVQRGRKLPLEIFKTKHKGWGLRCPRFIKAGTFIGVYLGEVITQSEAEIRGKKYDNVGVT--YLFDLDLfedqVDEYY 161

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 189217718 266 CIDAtRETGRLGRLINHSKSGNCHTKL----HNINNVPHLILVASRDINVGEELLYDYGDR 322
Cdd:cd20073  162 TVDA-QYCGDVTRFINHSCDPNLAIYSvlrdKSDSKIYDLAFFAIKDIPALEELTFDYSGR 221
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 208-326 2.66e-09

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 54.31  E-value: 2.66e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 208 GKGRGVIATRDFQRGEFV------VEYHGDLIEITDakrreasyaQDSATGCYMYyfqylntsycidatretgRLGRLIN 281
Cdd:cd20071    8 SKGRGLVATRDIEPGELIlvekplVSVPSNSFSLTD---------GLNEIGVGLF------------------PLASLLN 60

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 189217718 282 HSKSGNCHtklHNINNVPHLILVASRDINVGEELLYDYGDRRKSS 326
Cdd:cd20071   61 HSCDPNAV---VVFDGNGTLRVRALRDIKAGEELTISYIDPLLPR 102
SET_SETDB cd10541
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), ...
 190-320 3.93e-08

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), SET domain bifurcated 2 (SETDB2), and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380939 [Multi-domain]  Cd Length: 236  Bit Score: 53.32  E-value: 3.93e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 190 DELIQTGKEEGIKMHMITGKGRGVIATRDFQRGEFVVEYHGDLIeiTDAKRrEASYAQDSATgcymyYFQYLN----TSY 265
Cdd:cd10541   83 NRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGTFVCIYAGKIL--TDDFA-DKEGLEMGDE-----YFANLDhieeSCY 154

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 266 CIDATREtGRLGRLINHSKSGNCHTK-----LHNInNVPHLILVASRDINVGEELLYDYG 320
Cdd:cd10541  155 IIDAKLE-GNLGRYLNHSCSPNLFVQnvfvdTHDL-RFPWVAFFASKRIKAGTELTWDYN 212
SET_AtSUVH-like cd10545
SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar ...
 209-320 6.47e-08

SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar proteins; Arabidopsis thaliana SUVH protein (also termed suppressor of variegation 3-9 homolog protein) is a histone-lysine N-methyltransferase that methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. Some family members contain a post-SET domain which binds a Zn2+ ion. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380943 [Multi-domain]  Cd Length: 232  Bit Score: 52.41  E-value: 6.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 209 KGRGVIATRDFQRGEFVVEYHGDLIEITDAKRREAS--Y-------------------AQDSATGCYMYYFQYLNTSYCI 267
Cdd:cd10545   96 RGWGVRSWDSIPAGSFICEYVGELLDTSEADTRSGNddYlfdidnrqtnrgwdggqrlDVGMSDGERSSAEDEESSEFTI 175

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 189217718 268 DATrETGRLGRLINHSKSGN----CHTKLHNINNVPHLILVASRDINVGEELLYDYG 320
Cdd:cd10545  176 DAG-SFGNVARFINHSCSPNlfvqCVLYDHNDLRLPRVMLFAADNIPPLQELTYDYG 231
SET_SpSET3-like cd19183
SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET ...
 212-320 4.78e-07

SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET domain-containing protein 3 (SETD3) and similar proteins; Schizosaccharomyces pombe SETD3 functions as a transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. It is required for both, gene activation and repression.


Pssm-ID: 380960  Cd Length: 173  Bit Score: 49.32  E-value: 4.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 212 GVIATRDFQRGEFVVEYHGDLieitdakRREASYAQDSATgcyMYYF-----QYL----NTSYCIDaTRETGRLGRLINH 282
Cdd:cd19183   15 GLFADRPIPAGDPIQELLGEI-------GLQSEYIADPEN---QYQIlgapkPHVffhpQSPLYID-TRRSGSVARFIRR 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 189217718 283 SKSGNCH--TKLHNINNVPHLILVASRDINVGEELLYDYG 320
Cdd:cd19183   84 SCRPNAElvTVASDSGSVLKFVLYASRDISPGEEITIGWD 123
SET_Suv4-20-like cd10524
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ...
 209-321 1.52e-06

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation. The family also includes Suv4-20 homologs, lysine N-methyltransferase 5B (KMT5B) and lysine N-methyltransferase 5C (KMT5C). Both KMT5B (also termed lysine-specific methyltransferase 5B, or suppressor of variegation 4-20 homolog 1, or Su(var)4-20 homolog 1, or Suv4-20h1) and KMT5C (also termed lysine-specific methyltransferase 5C, or suppressor of variegation 4-20 homolog 2, or Su(var)4-20 homolog 2, or Suv4-20h2) are histone methyltransferases that specifically trimethylate 'Lys-20' of histone H4 (H4K20me3). They play central roles in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380922 [Multi-domain]  Cd Length: 141  Bit Score: 46.89  E-value: 1.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 209 KGRGVIATRDFQRGEFVVEYHGDLIEITDAKRREASyaqdsaTGCYMYYFQYlntsycidATRETGR---LG--RLINHS 283
Cdd:cd10524   18 YGAKIIATKPIKKGEKIHELCGCIAELSEEEEALLR------PGGNDFSVMY--------SSRKKCSqlwLGpaAFINHD 83

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 189217718 284 KSGNCHTKLHNINNVphlILVASRDINVGEELLYDYGD 321
Cdd:cd10524   84 CRPNCKFVPTGKSTA---CVKVLRDIEPGEEITVYYGD 118
SET_SETDB1 cd10517
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 209-320 1.80e-06

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.


Pssm-ID: 380915 [Multi-domain]  Cd Length: 288  Bit Score: 48.82  E-value: 1.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 209 KGRGVIATRDFQRGEFVVEYHGDLIEITDAKRREASYAQDsatgcymyYFQYLN------------------TSYCIDAT 270
Cdd:cd10517  139 KGWGIRCLDDIPKGSFVCIYAGQILTEDEANEEGLQYGDE--------YFAELDyievveklkegyesdveeHCYIIDAK 210

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 189217718 271 REtGRLGRLINHSKSGNCHtklhnINNV---------PHLILVASRDINVGEELLYDYG 320
Cdd:cd10517  211 SE-GNLGRYLNHSCSPNLF-----VQNVfvdthdlrfPWVAFFASRYIRAGTELTWDYN 263
SET_ATXR5_6-like cd10539
SET domain found in fungal protein lysine methyltransferase SET5 and similar protein; The ...
 274-319 1.29e-04

SET domain found in fungal protein lysine methyltransferase SET5 and similar protein; The family includes Arabidopsis thaliana ATXR5 and ATXR6. Both ATXR5 (also termed protein SET DOMAIN GROUP 15, or TRX-related protein 5) and ATXR6 (also termed protein SET DOMAIN GROUP 34, or TRX-related protein 6) function as histone methyltransferase that specifically monomethylates 'Lys-37' of histone H3 (H3K27me1). They are required for chromatin structure and gene silencing.


Pssm-ID: 380937  Cd Length: 138  Bit Score: 41.24  E-value: 1.29e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 189217718 274 GRLGRLI----NHSKSG----NCHTKLHNINNVPHLILVASRDINVGEELLYDY 319
Cdd:cd10539   72 GNIARFIsginNHTKDGkkkqNCKCVRYSINGEARVLLVATRDIAKGERLYYDY 125
SET_LSMT cd10527
SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; ...
 279-322 3.14e-04

SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; Rubisco LSMT is a non-histone protein methyl transferase responsible for the trimethylation of lysine14 in the large subunit of Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase). The family also includes SET domain-containing proteins, SETD3, SETD4 and SETD6, which belong to methyltransferase class VII that represents classical non-histone SET domain methyltransferases. Members in this family contain a SET domain and a C-terminal RubisCO LSMT substrate-binding (Rubis-subs-bind) domain.


Pssm-ID: 380925 [Multi-domain]  Cd Length: 236  Bit Score: 41.67  E-value: 3.14e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 189217718 279 LINHS-KSGNCHtkLHNINNVPHLILVASRDINVGEELLYDYGDR 322
Cdd:cd10527  182 MLNHSpDAPNVR--YEYDEDEGSFVLVATRDIAAGEEVFISYGPK 224
SET_SETDB2 cd10523
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) ...
 209-320 8.20e-04

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) and similar proteins; SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380921 [Multi-domain]  Cd Length: 266  Bit Score: 40.59  E-value: 8.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217718 209 KGRGVIATRDFQRGEFVVEYHGDLI------EITDAKRREASYAQDSATGCYMYYFQYL----NTSYCIDATREtGRLGR 278
Cdd:cd10523  118 KGWGVRCLDDIDKGTFVCIYAGRVLsrarspTEPLPPKLELPSENEVEVVTSWLILSKKrklrENVCFLDASKE-GNVGR 196

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 189217718 279 LINHSKSGN-----CHTKLHNiNNVPHLILVASRDINVGEELLYDYG 320
Cdd:cd10523  197 FLNHSCCPNlfvqnVFVDTHD-KNFPWVAFFTNRVVKAGTELTWDYS 242
SET_SETD9 cd10537
SET domain found in SET domain-containing protein 9 (SETD9) and similar proteins; SETD9 is an ...
 288-319 6.32e-03

SET domain found in SET domain-containing protein 9 (SETD9) and similar proteins; SETD9 is an uncharacterized protein that belongs to the class V-like SAM-binding methyltransferase superfamily.


Pssm-ID: 380935  Cd Length: 150  Bit Score: 36.78  E-value: 6.32e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 189217718 288 CHTKLHNINNVPHLILVASRDINVGEELLYDY 319
Cdd:cd10537  117 VFNMTRGKRPLRGVVLVATRDIKDGEELFSNY 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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