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Conserved domains on  [gi|189083786|ref|NP_001121143|]
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leukemia inhibitory factor receptor isoform a precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LIFR_D2 pfam17971
Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding ...
 131-244 7.58e-69

Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding module 1 (CBM1) found in Leukemia inhibitory factor receptor (LIFR) and OSM receptors (OSMR). LIFR has an extracellular region with a modular structure containing two cytokine-binding modules (CBM) separated by an Ig-like domain and followed by three membrane-proximal fibronectin type-III (FNIII) domains. The D2 domain in CBM1 shows structural similarity to the corresponding CBM domains of both gp130 and IL-6Ralpha because it contains conserved structural features like the WSXWS motif. The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation.


:

Pssm-ID: 375455  Cd Length: 114  Bit Score: 225.41  E-value: 7.58e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083786   131 NVSLIPDTPEILNLSADFSTSTLYLKWNDRGSVFPHRSNVIWEIKVLRKESMELVKLVTHNTTLNGKDTLHHWSWASDMP 210
Cdd:pfam17971    1 NVSLIPDTPQILNLTADFSTSTLHLKWNDKGSAFPYHSNVIWEIKVLRKEKMEIVTLVTYNTTLNGKDTVHHWNWTSDMP 80

                           90       100       110
                   ....*....|....*....|....*....|....
gi 189083786   211 LECAIHFVEIRCYIDNLHFSGLEEWSDWSPVKNI 244
Cdd:pfam17971   81 LECTSHSVRIRCYIDDVHFSGPKEWSEWSPLKNI 114
LIFR_N pfam18207
Leukemia inhibitory factor receptor N-terminal domain; This domain can be found in leukemia ...
 52-129 2.70e-43

Leukemia inhibitory factor receptor N-terminal domain; This domain can be found in leukemia inhibitory factor receptor (LIFR). LIFR is a cell surface receptor that mediates the actions of LIF and other interleukin-6 type cytokines through the formation of signalling complexes with gp130. This is the N-terminal domain, referred to as domain 1, which contains conserved disulfide bonds between Cys-10 to Cys-20 and Cys-37 to Cys-45.


:

Pssm-ID: 436347  Cd Length: 78  Bit Score: 151.71  E-value: 2.70e-43
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 189083786    52 DLKCVTNNLQVWNCSWKAPSGTGRGTDYEVCIENRSRSCYQLEKTSIKIPALSHGDYEITINSLHDFGSSTSKFTLNE 129
Cdd:pfam18207    1 DLKCITHNLQVWDCSWDAPSGAGHGTTYEFCIENRSHSCYKTEKTNIEIPALSPGDHEITINSLSGFGSSTSKFILNE 78
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 433-530 6.68e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.04  E-value: 6.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083786  433 PHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNSvQEQRNVTIKGVENSSYLValDKLNPYTLYTFRIRCS 512
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGS-GDWKEVEVTPGSETSYTL--TGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....*...
gi 189083786  513 TEtfWKWSKWSNKKQHLT 530
Cdd:cd00063    78 NG--GGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 729-821 9.68e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.18  E-value: 9.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083786  729 NFTVEDTSADSILVKWEdiPVEELRGFLRGY-LFYFGKGERDTSKMRVlesgrsdikvkniTDISQKTLRIADLQGKTSY 807
Cdd:cd00063     6 NLRVTDVTSTSVTLSWT--PPEDDGGPITGYvVEYREKGSGDWKEVEV-------------TPGSETSYTLTGLKPGTEY 70

                          90
                  ....*....|....
gi 189083786  808 HLVLRAYTDGGVGP 821
Cdd:cd00063    71 EFRVRAVNGGGESP 84
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 552-619 1.75e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam00041:

Pssm-ID: 473895 [Multi-domain]  Cd Length: 85  Bit Score: 38.55  E-value: 1.75e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 189083786   552 LIIYWKPLPinEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDK----NDYIISVVAKNSVGSSPPS 619
Cdd:pfam00041   16 LTVSWTPPP--DGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGlkpgTEYEVRVQAVNGGGEGPPS 85
 
Name Accession Description Interval E-value
LIFR_D2 pfam17971
Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding ...
 131-244 7.58e-69

Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding module 1 (CBM1) found in Leukemia inhibitory factor receptor (LIFR) and OSM receptors (OSMR). LIFR has an extracellular region with a modular structure containing two cytokine-binding modules (CBM) separated by an Ig-like domain and followed by three membrane-proximal fibronectin type-III (FNIII) domains. The D2 domain in CBM1 shows structural similarity to the corresponding CBM domains of both gp130 and IL-6Ralpha because it contains conserved structural features like the WSXWS motif. The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation.


Pssm-ID: 375455  Cd Length: 114  Bit Score: 225.41  E-value: 7.58e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083786   131 NVSLIPDTPEILNLSADFSTSTLYLKWNDRGSVFPHRSNVIWEIKVLRKESMELVKLVTHNTTLNGKDTLHHWSWASDMP 210
Cdd:pfam17971    1 NVSLIPDTPQILNLTADFSTSTLHLKWNDKGSAFPYHSNVIWEIKVLRKEKMEIVTLVTYNTTLNGKDTVHHWNWTSDMP 80

                           90       100       110
                   ....*....|....*....|....*....|....
gi 189083786   211 LECAIHFVEIRCYIDNLHFSGLEEWSDWSPVKNI 244
Cdd:pfam17971   81 LECTSHSVRIRCYIDDVHFSGPKEWSEWSPLKNI 114
LIFR_N pfam18207
Leukemia inhibitory factor receptor N-terminal domain; This domain can be found in leukemia ...
 52-129 2.70e-43

Leukemia inhibitory factor receptor N-terminal domain; This domain can be found in leukemia inhibitory factor receptor (LIFR). LIFR is a cell surface receptor that mediates the actions of LIF and other interleukin-6 type cytokines through the formation of signalling complexes with gp130. This is the N-terminal domain, referred to as domain 1, which contains conserved disulfide bonds between Cys-10 to Cys-20 and Cys-37 to Cys-45.


Pssm-ID: 436347  Cd Length: 78  Bit Score: 151.71  E-value: 2.70e-43
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 189083786    52 DLKCVTNNLQVWNCSWKAPSGTGRGTDYEVCIENRSRSCYQLEKTSIKIPALSHGDYEITINSLHDFGSSTSKFTLNE 129
Cdd:pfam18207    1 DLKCITHNLQVWDCSWDAPSGAGHGTTYEFCIENRSHSCYKTEKTNIEIPALSPGDHEITINSLSGFGSSTSKFILNE 78
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 433-530 6.68e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.04  E-value: 6.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083786  433 PHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNSvQEQRNVTIKGVENSSYLValDKLNPYTLYTFRIRCS 512
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGS-GDWKEVEVTPGSETSYTL--TGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....*...
gi 189083786  513 TEtfWKWSKWSNKKQHLT 530
Cdd:cd00063    78 NG--GGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 433-514 1.41e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.92  E-value: 1.41e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083786    433 PHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSsylVALDKLNPYTLYTFRIRCS 512
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTS---YTLTGLKPGTEYEFRVRAV 77


                    ..
gi 189083786    513 TE 514
Cdd:smart00060   78 NG 79
fn3 pfam00041
Fibronectin type III domain;
436-520 4.55e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.57  E-value: 4.55e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083786   436 PTSFKVKDINSTAVKLSWHLP----GNFAKInflcEIEIKKSNSVQEQRNVTIKGVENSsylVALDKLNPYTLYTFRIR- 510
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgnGPITGY----EVEYRPKNSGEPWNEITVPGTTTS---VTLTGLKPGTEYEVRVQa 75

                           90
                   ....*....|
gi 189083786   511 CSTETFWKWS 520
Cdd:pfam00041   76 VNGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 729-821 9.68e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.18  E-value: 9.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083786  729 NFTVEDTSADSILVKWEdiPVEELRGFLRGY-LFYFGKGERDTSKMRVlesgrsdikvkniTDISQKTLRIADLQGKTSY 807
Cdd:cd00063     6 NLRVTDVTSTSVTLSWT--PPEDDGGPITGYvVEYREKGSGDWKEVEV-------------TPGSETSYTLTGLKPGTEY 70

                          90
                  ....*....|....
gi 189083786  808 HLVLRAYTDGGVGP 821
Cdd:cd00063    71 EFRVRAVNGGGESP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 724-820 1.62e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.45  E-value: 1.62e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083786    724 PIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYlfyfgkgerdtskmRVLESGRSDIKVKNITDISQKTLRIADLQG 803
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGY--------------RVEYREEGSEWKEVNVTPSSTSYTLTGLKP 66

                            90
                    ....*....|....*..
gi 189083786    804 KTSYHLVLRAYTDGGVG 820
Cdd:smart00060   67 GTEYEFRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
729-822 3.32e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.48  E-value: 3.32e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083786   729 NFTVEDTSADSILVKWEdiPVEELRGFLRGYlfyfgkgerdtsKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYH 808
Cdd:pfam00041    5 NLTVTDVTSTSLTVSWT--PPPDGNGPITGY------------EVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYE 70

                           90
                   ....*....|....
gi 189083786   809 LVLRAYTDGGVGPE 822
Cdd:pfam00041   71 VRVQAVNGGGEGPP 84
fn3 pfam00041
Fibronectin type III domain;
552-619 1.75e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.55  E-value: 1.75e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 189083786   552 LIIYWKPLPinEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDK----NDYIISVVAKNSVGSSPPS 619
Cdd:pfam00041   16 LTVSWTPPP--DGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGlkpgTEYEVRVQAVNGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 541-623 6.64e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.09  E-value: 6.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083786  541 TWREWSSDgkNLIIYWKPLPinEANGKILSYNVSCS--SDEETQSLSEIPDPQHKAEIR-LDKN-DYIISVVAKNSVGSS 616
Cdd:cd00063     8 RVTDVTST--SVTLSWTPPE--DDGGPITGYVVEYRekGSGDWKEVEVTPGSETSYTLTgLKPGtEYEFRVRAVNGGGES 83


                  ....*..
gi 189083786  617 PPSKIAS 623
Cdd:cd00063    84 PPSESVT 90
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 541-616 8.40e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 36.44  E-value: 8.40e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 189083786    541 TWREWSSDgkNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIR-LDKN-DYIISVVAKNSVGSS 616
Cdd:smart00060    8 RVTDVTST--SVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTgLKPGtEYEFRVRAVNGAGEG 83
 
Name Accession Description Interval E-value
LIFR_D2 pfam17971
Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding ...
 131-244 7.58e-69

Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding module 1 (CBM1) found in Leukemia inhibitory factor receptor (LIFR) and OSM receptors (OSMR). LIFR has an extracellular region with a modular structure containing two cytokine-binding modules (CBM) separated by an Ig-like domain and followed by three membrane-proximal fibronectin type-III (FNIII) domains. The D2 domain in CBM1 shows structural similarity to the corresponding CBM domains of both gp130 and IL-6Ralpha because it contains conserved structural features like the WSXWS motif. The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation.


Pssm-ID: 375455  Cd Length: 114  Bit Score: 225.41  E-value: 7.58e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083786   131 NVSLIPDTPEILNLSADFSTSTLYLKWNDRGSVFPHRSNVIWEIKVLRKESMELVKLVTHNTTLNGKDTLHHWSWASDMP 210
Cdd:pfam17971    1 NVSLIPDTPQILNLTADFSTSTLHLKWNDKGSAFPYHSNVIWEIKVLRKEKMEIVTLVTYNTTLNGKDTVHHWNWTSDMP 80

                           90       100       110
                   ....*....|....*....|....*....|....
gi 189083786   211 LECAIHFVEIRCYIDNLHFSGLEEWSDWSPVKNI 244
Cdd:pfam17971   81 LECTSHSVRIRCYIDDVHFSGPKEWSEWSPLKNI 114
LIFR_N pfam18207
Leukemia inhibitory factor receptor N-terminal domain; This domain can be found in leukemia ...
 52-129 2.70e-43

Leukemia inhibitory factor receptor N-terminal domain; This domain can be found in leukemia inhibitory factor receptor (LIFR). LIFR is a cell surface receptor that mediates the actions of LIF and other interleukin-6 type cytokines through the formation of signalling complexes with gp130. This is the N-terminal domain, referred to as domain 1, which contains conserved disulfide bonds between Cys-10 to Cys-20 and Cys-37 to Cys-45.


Pssm-ID: 436347  Cd Length: 78  Bit Score: 151.71  E-value: 2.70e-43
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 189083786    52 DLKCVTNNLQVWNCSWKAPSGTGRGTDYEVCIENRSRSCYQLEKTSIKIPALSHGDYEITINSLHDFGSSTSKFTLNE 129
Cdd:pfam18207    1 DLKCITHNLQVWDCSWDAPSGAGHGTTYEFCIENRSHSCYKTEKTNIEIPALSPGDHEITINSLSGFGSSTSKFILNE 78
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 433-530 6.68e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.04  E-value: 6.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083786  433 PHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNSvQEQRNVTIKGVENSSYLValDKLNPYTLYTFRIRCS 512
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGS-GDWKEVEVTPGSETSYTL--TGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....*...
gi 189083786  513 TEtfWKWSKWSNKKQHLT 530
Cdd:cd00063    78 NG--GGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 433-514 1.41e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.92  E-value: 1.41e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083786    433 PHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSsylVALDKLNPYTLYTFRIRCS 512
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTS---YTLTGLKPGTEYEFRVRAV 77


                    ..
gi 189083786    513 TE 514
Cdd:smart00060   78 NG 79
fn3 pfam00041
Fibronectin type III domain;
436-520 4.55e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.57  E-value: 4.55e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083786   436 PTSFKVKDINSTAVKLSWHLP----GNFAKInflcEIEIKKSNSVQEQRNVTIKGVENSsylVALDKLNPYTLYTFRIR- 510
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgnGPITGY----EVEYRPKNSGEPWNEITVPGTTTS---VTLTGLKPGTEYEVRVQa 75

                           90
                   ....*....|
gi 189083786   511 CSTETFWKWS 520
Cdd:pfam00041   76 VNGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 729-821 9.68e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.18  E-value: 9.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083786  729 NFTVEDTSADSILVKWEdiPVEELRGFLRGY-LFYFGKGERDTSKMRVlesgrsdikvkniTDISQKTLRIADLQGKTSY 807
Cdd:cd00063     6 NLRVTDVTSTSVTLSWT--PPEDDGGPITGYvVEYREKGSGDWKEVEV-------------TPGSETSYTLTGLKPGTEY 70

                          90
                  ....*....|....
gi 189083786  808 HLVLRAYTDGGVGP 821
Cdd:cd00063    71 EFRVRAVNGGGESP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 724-820 1.62e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.45  E-value: 1.62e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083786    724 PIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYlfyfgkgerdtskmRVLESGRSDIKVKNITDISQKTLRIADLQG 803
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGY--------------RVEYREEGSEWKEVNVTPSSTSYTLTGLKP 66

                            90
                    ....*....|....*..
gi 189083786    804 KTSYHLVLRAYTDGGVG 820
Cdd:smart00060   67 GTEYEFRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
729-822 3.32e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.48  E-value: 3.32e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083786   729 NFTVEDTSADSILVKWEdiPVEELRGFLRGYlfyfgkgerdtsKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYH 808
Cdd:pfam00041    5 NLTVTDVTSTSLTVSWT--PPPDGNGPITGY------------EVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYE 70

                           90
                   ....*....|....
gi 189083786   809 LVLRAYTDGGVGPE 822
Cdd:pfam00041   71 VRVQAVNGGGEGPP 84
fn3 pfam00041
Fibronectin type III domain;
552-619 1.75e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.55  E-value: 1.75e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 189083786   552 LIIYWKPLPinEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDK----NDYIISVVAKNSVGSSPPS 619
Cdd:pfam00041   16 LTVSWTPPP--DGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGlkpgTEYEVRVQAVNGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 541-623 6.64e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.09  E-value: 6.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189083786  541 TWREWSSDgkNLIIYWKPLPinEANGKILSYNVSCS--SDEETQSLSEIPDPQHKAEIR-LDKN-DYIISVVAKNSVGSS 616
Cdd:cd00063     8 RVTDVTST--SVTLSWTPPE--DDGGPITGYVVEYRekGSGDWKEVEVTPGSETSYTLTgLKPGtEYEFRVRAVNGGGES 83


                  ....*..
gi 189083786  617 PPSKIAS 623
Cdd:cd00063    84 PPSESVT 90
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 541-616 8.40e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 36.44  E-value: 8.40e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 189083786    541 TWREWSSDgkNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIR-LDKN-DYIISVVAKNSVGSS 616
Cdd:smart00060    8 RVTDVTST--SVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTgLKPGtEYEFRVRAVNGAGEG 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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