|
Name |
Accession |
Description |
Interval |
E-value |
| Arm_APC_u3 |
pfam16629 |
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ... |
714-1001 |
1.22e-166 |
|
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
:
Pssm-ID: 435476 Cd Length: 293 Bit Score: 515.29 E-value: 1.22e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 714 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRSKQRHKQSLYGDYVFDTNRHDDN-- 791
Cdd:pfam16629 1 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNVYSEYVLDSGRHDDSvc 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 792 RSDNFNTGNMTVLSPYLNTTVLPSSSSSRG--SLDSSRSEKDRSLERERGIGLGNYHPATENPGTSSKR-GLQISTTAAQ 868
Cdd:pfam16629 81 RSDNFNTGNVTVLSPYLNTTVLPSSSSRDSrgNAESSRSEKDRSLDRERGAGLSNFHPATENSGNSSKRiGMQISTTAAQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 869 IAKVMEEVSAIHTSQEDRSSGSTTELHCVTDERNALRRSSAAHTHSNTYNFTKSENSNRTCSMPYAKLEYKRSSNDSLNS 948
Cdd:pfam16629 161 IAKVMEEVSSMHISQEDRSSGSTSDMHCMQDDRNSIRRSSTAHPHSNVYSFNKSESSNRPCPMPYMKMEYKRASNDSLNS 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 306922386 949 VSSSDGYGKRGQMKPSIESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDG 1001
Cdd:pfam16629 241 VSSSDGYGKRGQMKPSVESYSEDDEGKFCSYGKYPADLAHKIHSANHMDDNDG 293
|
|
| APC_basic |
pfam05956 |
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ... |
2205-2550 |
9.08e-109 |
|
APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.
:
Pssm-ID: 428690 [Multi-domain] Cd Length: 336 Bit Score: 351.10 E-value: 9.08e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2205 SISRGRTMIHIPGVRNSSSSTSPVSKKGPPLKTPASKSPSEGQTATTS-PRGAKPSVKSELSPVARQTSQIGGSSKAPSR 2283
Cdd:pfam05956 1 VVFRGRTVIYMPGVKESQPSTSPPPKKTPPKTDAPAKNPNLGQQRSRSlHRLGKPSELADLSPPKRSATPPARISKAPSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2284 SGSRDSTPSRPAQQPLSRPIQSPGRNSISPGRNgisppnKLSQLPRTSSPSTASTKSSGSgKMSYTSPGRQMSQQNLTKQ 2363
Cdd:pfam05956 81 GSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGRN------KLSPLPKTKSPARASTKKSGS-HKTQKSPVRIPFMQTPTKQ 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2364 TGLSKNASSI------PRSESASKGLNqmnngNGANKKVELSRMSSTKSSGSESDRSerpVLVRQSTFIKEAPSPTLRRK 2437
Cdd:pfam05956 154 TGLPRNPSPLvtnqpePRSESASKGLR-----SLPGKRLDLVRMSSARSSGSESDRS---GFLRQLTFIKESPSLLLRRR 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2438 LEESASfESLSPSSRPASPTRSQaqtpvlsPSLPDMSLSTHSSVQAGGWRKLPPNLSPTIEYNDGRPAKRHDIARSHSES 2517
Cdd:pfam05956 226 LELSAS-ESLSPSSQPASPRRSR-------PGLPAVFLCSSRCQELKGWRKQPPNPNSRAEPSDRPLTRRRPPRRTSSES 297
|
330 340 350
....*....|....*....|....*....|...
gi 306922386 2518 PSRLPInRSGTWKREHSKHSSSLPRVSTWRRTG 2550
Cdd:pfam05956 298 PSRLPV-RNGTWKRETFKRYSSLPHINVWRRTG 329
|
|
| EB1_binding |
pfam05937 |
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the ... |
2652-2825 |
1.90e-89 |
|
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the microtubule-associating protein EB-1. At the C-terminus of the alignment is also a pfam00595 binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins.
:
Pssm-ID: 399141 Cd Length: 174 Bit Score: 288.82 E-value: 1.90e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2652 RSGRSPTGNTPPVIDSVSEKANPNIKDSKDNQAKQNVGNGSVPMRTVGLENRLNSFIQVDAPDQKGTEIKPGQNNPVPVS 2731
Cdd:pfam05937 1 RSGRSPTGNTPPVIDSVPEKGIKDEKDSKDPQAKQNMGNGNVPVRTVGLENRLNSFIQSDSPDKKGTETKPLQNNPVPTP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2732 ETNESSIVERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVNNNTKKRDSKTDSTESSGTQ 2811
Cdd:pfam05937 81 ETNENPVSERTPFSSSSSSKHSSPSGAVAARVTPFNYNPSPRKSSADSSSARPSQIPTPVNNSTKKRDSKTESTDSSGNQ 160
|
170
....*....|....
gi 306922386 2812 SPKRHSGSYLVTSV 2825
Cdd:pfam05937 161 SPKRHSGSYLVTSV 174
|
|
| APC_u5 |
pfam16630 |
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of ... |
1018-1117 |
8.98e-57 |
|
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of natively unstructured sequence lying between the first and the second 15-residue beta-catenin binding motifs, APC_15aa, pfam05972, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
:
Pssm-ID: 406923 Cd Length: 100 Bit Score: 192.04 E-value: 8.98e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 1018 LNSGRQSPSQNERWARPKHIIEDEIKQSEQRQSRNQSTTYPVYTESTDDKHLKFQPHFGQQECVSPYRSRGANGSETNRV 1097
Cdd:pfam16630 1 LNSGRQSPSQNERWARPKHIIEDEMKQSEQRQPRSQSTTYPVYTESGDDKHMKFQPRFGQQECVSPFRSRGSNGSEQSRV 80
|
90 100
....*....|....*....|
gi 306922386 1098 GSNHGINQNVSQSLCQEDDY 1117
Cdd:pfam16630 81 GSSHGINQKVSQSLCQVDDY 100
|
|
| APC_u14 |
pfam16635 |
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively ... |
1728-1821 |
4.16e-47 |
|
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively unstructured sequence lying between the second SAMP pfam05924, and the fifth creatine-rich region, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
:
Pssm-ID: 435479 Cd Length: 94 Bit Score: 164.24 E-value: 4.16e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 1728 IMDQVQQASASSSAPNKNQLDGKKKKPTSPVKPIPQNTEYRTRVRKNADSKNNLNAERVFSDNKDSKKQNLKNNSKVFND 1807
Cdd:pfam16635 1 IMDQIQQASAASSGGSKSQQDGEKKKPTSPVKPMPQSSEYRARVRKNTESKNNLNSERSYPDNKESKKQNLKNNSRDFND 80
|
90
....*....|....
gi 306922386 1808 KLPNNEDRVRGSFA 1821
Cdd:pfam16635 81 KLPNNEERTRGSFA 94
|
|
| APC_rep |
pfam18797 |
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ... |
375-448 |
3.50e-45 |
|
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.
:
Pssm-ID: 465870 Cd Length: 74 Bit Score: 158.09 E-value: 3.50e-45
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 306922386 375 SQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAVCVLMKLSFDEEHRHAM 448
Cdd:pfam18797 1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
|
|
| APC_u9 |
pfam16633 |
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of ... |
1265-1350 |
1.64e-35 |
|
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of natively unstructured sequence lying between the first and second APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
:
Pssm-ID: 435478 Cd Length: 89 Bit Score: 131.15 E-value: 1.64e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 1265 AEDEI-GCNQTTQEADSANTLQIAEIKEKIGTRSAEDPVSEVPAVSQHPRTKSSRLQGSSLS-SESARHKAVEFSSGAKS 1342
Cdd:pfam16633 2 AEDEIeGRDQATRSTDNYNTLQITELKENSGAVSTEQTVSEVPSSSQHIRTKPNRLQASNLSpSDSSRHKAVEFSSGAKS 81
|
....*...
gi 306922386 1343 PSKSGAQT 1350
Cdd:pfam16633 82 PSKSGAQT 89
|
|
| APC_u15 |
pfam16636 |
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of ... |
1855-1929 |
2.14e-31 |
|
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of natively unstructured sequence lying between the fifth and sixth creatine-rich, APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
:
Pssm-ID: 435480 Cd Length: 81 Bit Score: 118.81 E-value: 2.14e-31
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 306922386 1855 DLSREKAELRKAKENKESEAKVTSHTELTSNQQSANKTQAIAKQPINRGQPKPILQKQSTFPQSSKDIPDRGAAT 1929
Cdd:pfam16636 7 DLSREKAELRKGKETKETETKVTSHIEQPSNQQSTNRTQACQKHPPNRGQPKPLLQKQTTFPQSSKDIPDRGAAT 81
|
|
| APC_u13 |
pfam16634 |
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively ... |
1644-1697 |
1.18e-24 |
|
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively unstructured sequence lying between the fourth creatine-rich region, APC_crr, pfam05923, and the SAMP pfam05924, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
:
Pssm-ID: 406927 Cd Length: 54 Bit Score: 98.71 E-value: 1.18e-24
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 306922386 1644 IESPPNELAAGEGVRGGAQSGEFEKRDTIPTEGRSTDEAQGGKTSSVTIPELDD 1697
Cdd:pfam16634 1 IESPPNELANAESTGTGAESAEFEKRDTIPTEGRSTDDAQRGKKSNITTSALDD 54
|
|
| Suppressor_APC |
pfam11414 |
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ... |
137-217 |
1.81e-22 |
|
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.
:
Pssm-ID: 463275 Cd Length: 82 Bit Score: 93.47 E-value: 1.81e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 137 SRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTE-NFSLQTDMTRRQLEYEARQIRVAMEEQLG 215
Cdd:pfam11414 1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGtYFDYGSDAQQERLEFLLARIQEVNRCLGG 80
|
..
gi 306922386 216 TC 217
Cdd:pfam11414 81 LI 82
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1619-1642 |
1.71e-07 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
:
Pssm-ID: 461781 Cd Length: 24 Bit Score: 49.30 E-value: 1.71e-07
|
| ARM |
smart00185 |
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ... |
631-671 |
4.58e-07 |
|
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.
:
Pssm-ID: 214547 [Multi-domain] Cd Length: 41 Bit Score: 48.19 E-value: 4.58e-07
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 306922386 631 NEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSA 671
Cdd:smart00185 1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
|
|
| SAMP |
pfam05924 |
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ... |
2015-2034 |
3.28e-05 |
|
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.
:
Pssm-ID: 461782 Cd Length: 22 Bit Score: 42.58 E-value: 3.28e-05
|
| ARM |
smart00185 |
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ... |
494-535 |
5.22e-04 |
|
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.
:
Pssm-ID: 214547 [Multi-domain] Cd Length: 41 Bit Score: 39.72 E-value: 5.22e-04
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 306922386 494 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLSW 535
Cdd:smart00185 1 DDENKQAVVDA-GGLPALVELLKSEDEEVVKEAAWALSNLSS 41
|
|
| Arm |
pfam00514 |
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
673-713 |
6.96e-04 |
|
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.
:
Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 39.36 E-value: 6.96e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 306922386 673 NPKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMA 713
Cdd:pfam00514 1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
|
|
| SAMP |
pfam05924 |
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1698-1719 |
1.26e-03 |
|
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.
:
Pssm-ID: 461782 Cd Length: 22 Bit Score: 38.34 E-value: 1.26e-03
|
| PTZ00449 super family |
cl33186 |
104 kDa microneme/rhoptry antigen; Provisional |
1273-1683 |
3.45e-03 |
|
104 kDa microneme/rhoptry antigen; Provisional
The actual alignment was detected with superfamily member PTZ00449:
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 43.14 E-value: 3.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 1273 QTTQEAD---SANTLQIAEIKEKIGTRSAEDPvsEVPAVSQHPRTKSSRLQGSSLSSESARHKAVEFSSGAKSPSKSGAQ 1349
Cdd:PTZ00449 480 QFTQEIKkliKKSKKKLAPIEEEDSDKHDEPP--EGPEASGLPPKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEV 557
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 1350 TPKSPP--EHYVQETPLMFSRCT----SVSSLDSFESRSIASSVQ-SEPCSGMVSGIISPSDLPDSPGQTMPPSRSKTPP 1422
Cdd:PTZ00449 558 GKKPGPakEHKPSKIPTLSKKPEfpkdPKHPKDPEEPKKPKRPRSaQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPP 637
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 1423 PPPQTAQTKR-EVPK----NKAPTAEKRESGPK------QAAVNAAVQRVQvlpdadtllhfaTESTPDGFSCSSSLSAL 1491
Cdd:PTZ00449 638 PPQRPSSPERpEGPKiiksPKPPKSPKPPFDPKfkekfyDDYLDAAAKSKE------------TKTTVVLDESFESILKE 705
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 1492 SLDEPFIQKDVELRIMPPVQENDNG------NETESEQPKESNENQEKEAEKTIDSEKDLLDDSDDDDIEILEECIISAM 1565
Cdd:PTZ00449 706 TLPETPGTPFTTPRPLPPKLPRDEEfpfepiGDPDAEQPDDIEFFTPPEEERTFFHETPADTPLPDILAEEFKEEDIHAE 785
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 1566 PTKSSRKAKKPAQTASKLPPPVARKPSqlpvyklLPSQNRLQPQKHVSFTPGDDMPRVYCVE--GTPINFSTATSLSDL- 1642
Cdd:PTZ00449 786 TGEPDEAMKRPDSPSEHEDKPPGDHPS-------LPKKRHRLDGLALSTTDLESDAGRIAKDasGKIVKLKRSKSFDDLt 858
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 306922386 1643 TIESPPNELAAGEGVRGGAQSGEFEKRDTIPTEGRSTDEAQ 1683
Cdd:PTZ00449 859 TVEEAEEMGAEARKIVVDDDGTEADDEDTHPPEEKHKSEVR 899
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1239-1256 |
7.34e-03 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
:
Pssm-ID: 461781 Cd Length: 24 Bit Score: 36.20 E-value: 7.34e-03
|
| ARM |
smart00185 |
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ... |
322-374 |
8.05e-03 |
|
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.
:
Pssm-ID: 214547 [Multi-domain] Cd Length: 41 Bit Score: 36.25 E-value: 8.05e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 306922386 322 SQDSCISMRQSGCLPLLIQLLHgndkdsvllgnsRGSKEARARASAALHNIIH 374
Cdd:smart00185 1 DDENKQAVVDAGGLPALVELLK------------SEDEEVVKEAAWALSNLSS 41
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Arm_APC_u3 |
pfam16629 |
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ... |
714-1001 |
1.22e-166 |
|
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
Pssm-ID: 435476 Cd Length: 293 Bit Score: 515.29 E-value: 1.22e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 714 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRSKQRHKQSLYGDYVFDTNRHDDN-- 791
Cdd:pfam16629 1 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNVYSEYVLDSGRHDDSvc 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 792 RSDNFNTGNMTVLSPYLNTTVLPSSSSSRG--SLDSSRSEKDRSLERERGIGLGNYHPATENPGTSSKR-GLQISTTAAQ 868
Cdd:pfam16629 81 RSDNFNTGNVTVLSPYLNTTVLPSSSSRDSrgNAESSRSEKDRSLDRERGAGLSNFHPATENSGNSSKRiGMQISTTAAQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 869 IAKVMEEVSAIHTSQEDRSSGSTTELHCVTDERNALRRSSAAHTHSNTYNFTKSENSNRTCSMPYAKLEYKRSSNDSLNS 948
Cdd:pfam16629 161 IAKVMEEVSSMHISQEDRSSGSTSDMHCMQDDRNSIRRSSTAHPHSNVYSFNKSESSNRPCPMPYMKMEYKRASNDSLNS 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 306922386 949 VSSSDGYGKRGQMKPSIESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDG 1001
Cdd:pfam16629 241 VSSSDGYGKRGQMKPSVESYSEDDEGKFCSYGKYPADLAHKIHSANHMDDNDG 293
|
|
| APC_basic |
pfam05956 |
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ... |
2205-2550 |
9.08e-109 |
|
APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.
Pssm-ID: 428690 [Multi-domain] Cd Length: 336 Bit Score: 351.10 E-value: 9.08e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2205 SISRGRTMIHIPGVRNSSSSTSPVSKKGPPLKTPASKSPSEGQTATTS-PRGAKPSVKSELSPVARQTSQIGGSSKAPSR 2283
Cdd:pfam05956 1 VVFRGRTVIYMPGVKESQPSTSPPPKKTPPKTDAPAKNPNLGQQRSRSlHRLGKPSELADLSPPKRSATPPARISKAPSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2284 SGSRDSTPSRPAQQPLSRPIQSPGRNSISPGRNgisppnKLSQLPRTSSPSTASTKSSGSgKMSYTSPGRQMSQQNLTKQ 2363
Cdd:pfam05956 81 GSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGRN------KLSPLPKTKSPARASTKKSGS-HKTQKSPVRIPFMQTPTKQ 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2364 TGLSKNASSI------PRSESASKGLNqmnngNGANKKVELSRMSSTKSSGSESDRSerpVLVRQSTFIKEAPSPTLRRK 2437
Cdd:pfam05956 154 TGLPRNPSPLvtnqpePRSESASKGLR-----SLPGKRLDLVRMSSARSSGSESDRS---GFLRQLTFIKESPSLLLRRR 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2438 LEESASfESLSPSSRPASPTRSQaqtpvlsPSLPDMSLSTHSSVQAGGWRKLPPNLSPTIEYNDGRPAKRHDIARSHSES 2517
Cdd:pfam05956 226 LELSAS-ESLSPSSQPASPRRSR-------PGLPAVFLCSSRCQELKGWRKQPPNPNSRAEPSDRPLTRRRPPRRTSSES 297
|
330 340 350
....*....|....*....|....*....|...
gi 306922386 2518 PSRLPInRSGTWKREHSKHSSSLPRVSTWRRTG 2550
Cdd:pfam05956 298 PSRLPV-RNGTWKRETFKRYSSLPHINVWRRTG 329
|
|
| EB1_binding |
pfam05937 |
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the ... |
2652-2825 |
1.90e-89 |
|
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the microtubule-associating protein EB-1. At the C-terminus of the alignment is also a pfam00595 binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins.
Pssm-ID: 399141 Cd Length: 174 Bit Score: 288.82 E-value: 1.90e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2652 RSGRSPTGNTPPVIDSVSEKANPNIKDSKDNQAKQNVGNGSVPMRTVGLENRLNSFIQVDAPDQKGTEIKPGQNNPVPVS 2731
Cdd:pfam05937 1 RSGRSPTGNTPPVIDSVPEKGIKDEKDSKDPQAKQNMGNGNVPVRTVGLENRLNSFIQSDSPDKKGTETKPLQNNPVPTP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2732 ETNESSIVERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVNNNTKKRDSKTDSTESSGTQ 2811
Cdd:pfam05937 81 ETNENPVSERTPFSSSSSSKHSSPSGAVAARVTPFNYNPSPRKSSADSSSARPSQIPTPVNNSTKKRDSKTESTDSSGNQ 160
|
170
....*....|....
gi 306922386 2812 SPKRHSGSYLVTSV 2825
Cdd:pfam05937 161 SPKRHSGSYLVTSV 174
|
|
| APC_u5 |
pfam16630 |
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of ... |
1018-1117 |
8.98e-57 |
|
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of natively unstructured sequence lying between the first and the second 15-residue beta-catenin binding motifs, APC_15aa, pfam05972, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
Pssm-ID: 406923 Cd Length: 100 Bit Score: 192.04 E-value: 8.98e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 1018 LNSGRQSPSQNERWARPKHIIEDEIKQSEQRQSRNQSTTYPVYTESTDDKHLKFQPHFGQQECVSPYRSRGANGSETNRV 1097
Cdd:pfam16630 1 LNSGRQSPSQNERWARPKHIIEDEMKQSEQRQPRSQSTTYPVYTESGDDKHMKFQPRFGQQECVSPFRSRGSNGSEQSRV 80
|
90 100
....*....|....*....|
gi 306922386 1098 GSNHGINQNVSQSLCQEDDY 1117
Cdd:pfam16630 81 GSSHGINQKVSQSLCQVDDY 100
|
|
| APC_u14 |
pfam16635 |
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively ... |
1728-1821 |
4.16e-47 |
|
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively unstructured sequence lying between the second SAMP pfam05924, and the fifth creatine-rich region, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
Pssm-ID: 435479 Cd Length: 94 Bit Score: 164.24 E-value: 4.16e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 1728 IMDQVQQASASSSAPNKNQLDGKKKKPTSPVKPIPQNTEYRTRVRKNADSKNNLNAERVFSDNKDSKKQNLKNNSKVFND 1807
Cdd:pfam16635 1 IMDQIQQASAASSGGSKSQQDGEKKKPTSPVKPMPQSSEYRARVRKNTESKNNLNSERSYPDNKESKKQNLKNNSRDFND 80
|
90
....*....|....
gi 306922386 1808 KLPNNEDRVRGSFA 1821
Cdd:pfam16635 81 KLPNNEERTRGSFA 94
|
|
| APC_rep |
pfam18797 |
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ... |
375-448 |
3.50e-45 |
|
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.
Pssm-ID: 465870 Cd Length: 74 Bit Score: 158.09 E-value: 3.50e-45
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 306922386 375 SQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAVCVLMKLSFDEEHRHAM 448
Cdd:pfam18797 1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
|
|
| APC_u9 |
pfam16633 |
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of ... |
1265-1350 |
1.64e-35 |
|
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of natively unstructured sequence lying between the first and second APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
Pssm-ID: 435478 Cd Length: 89 Bit Score: 131.15 E-value: 1.64e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 1265 AEDEI-GCNQTTQEADSANTLQIAEIKEKIGTRSAEDPVSEVPAVSQHPRTKSSRLQGSSLS-SESARHKAVEFSSGAKS 1342
Cdd:pfam16633 2 AEDEIeGRDQATRSTDNYNTLQITELKENSGAVSTEQTVSEVPSSSQHIRTKPNRLQASNLSpSDSSRHKAVEFSSGAKS 81
|
....*...
gi 306922386 1343 PSKSGAQT 1350
Cdd:pfam16633 82 PSKSGAQT 89
|
|
| APC_u15 |
pfam16636 |
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of ... |
1855-1929 |
2.14e-31 |
|
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of natively unstructured sequence lying between the fifth and sixth creatine-rich, APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
Pssm-ID: 435480 Cd Length: 81 Bit Score: 118.81 E-value: 2.14e-31
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 306922386 1855 DLSREKAELRKAKENKESEAKVTSHTELTSNQQSANKTQAIAKQPINRGQPKPILQKQSTFPQSSKDIPDRGAAT 1929
Cdd:pfam16636 7 DLSREKAELRKGKETKETETKVTSHIEQPSNQQSTNRTQACQKHPPNRGQPKPLLQKQTTFPQSSKDIPDRGAAT 81
|
|
| APC_u13 |
pfam16634 |
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively ... |
1644-1697 |
1.18e-24 |
|
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively unstructured sequence lying between the fourth creatine-rich region, APC_crr, pfam05923, and the SAMP pfam05924, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
Pssm-ID: 406927 Cd Length: 54 Bit Score: 98.71 E-value: 1.18e-24
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 306922386 1644 IESPPNELAAGEGVRGGAQSGEFEKRDTIPTEGRSTDEAQGGKTSSVTIPELDD 1697
Cdd:pfam16634 1 IESPPNELANAESTGTGAESAEFEKRDTIPTEGRSTDDAQRGKKSNITTSALDD 54
|
|
| Suppressor_APC |
pfam11414 |
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ... |
137-217 |
1.81e-22 |
|
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.
Pssm-ID: 463275 Cd Length: 82 Bit Score: 93.47 E-value: 1.81e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 137 SRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTE-NFSLQTDMTRRQLEYEARQIRVAMEEQLG 215
Cdd:pfam11414 1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGtYFDYGSDAQQERLEFLLARIQEVNRCLGG 80
|
..
gi 306922386 216 TC 217
Cdd:pfam11414 81 LI 82
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1619-1642 |
1.71e-07 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
Pssm-ID: 461781 Cd Length: 24 Bit Score: 49.30 E-value: 1.71e-07
|
| ARM |
smart00185 |
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ... |
631-671 |
4.58e-07 |
|
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.
Pssm-ID: 214547 [Multi-domain] Cd Length: 41 Bit Score: 48.19 E-value: 4.58e-07
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 306922386 631 NEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSA 671
Cdd:smart00185 1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
|
|
| Arm |
pfam00514 |
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
631-671 |
6.22e-07 |
|
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.
Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 47.83 E-value: 6.22e-07
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 306922386 631 NEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSA 671
Cdd:pfam00514 1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
2233-2546 |
1.35e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 54.56 E-value: 1.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2233 PPLKTPASKsPSEGQTATTSPRGAKPSVKSE----LSPVARQTSQIGGSSKAPSRSGSRDSTPSRPAQQPLSRPIQSPGR 2308
Cdd:PHA03247 2703 PPPPTPEPA-PHALVSATPLPPGPAAARQASpalpAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR 2781
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2309 NSISPGRNGISPPNKLSQLPRTSSPSTASTKSSGSGKMSYTSPGrqmsqqnltkqTGLSKNASSIPRSESASKGLNQ--M 2386
Cdd:PHA03247 2782 RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPA-----------GPLPPPTSAQPTAPPPPPGPPPpsL 2850
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2387 NNGNGANKKVELSRMSSTKSSGSESDRSERPVLVRqstfikeAPSPTLRRKLEESA-SFESLSPSSRPASPTRSQAQTPV 2465
Cdd:PHA03247 2851 PLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRR-------LARPAVSRSTESFAlPPDQPERPPQPQAPPPPQPQPQP 2923
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2466 LSPSLPDMSLSTHSSVQAggwrKLPPNLSPTieyNDGRPAKRHDIARSHSESPSRLPINRSGTWK----RE------HSK 2535
Cdd:PHA03247 2924 PPPPQPQPPPPPPPRPQP----PLAPTTDPA---GAGEPSGAVPQPWLGALVPGRVAVPRFRVPQpapsREapasstPPL 2996
|
330
....*....|.
gi 306922386 2536 HSSSLPRVSTW 2546
Cdd:PHA03247 2997 TGHSLSRVSSW 3007
|
|
| SAMP |
pfam05924 |
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ... |
2015-2034 |
3.28e-05 |
|
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.
Pssm-ID: 461782 Cd Length: 22 Bit Score: 42.58 E-value: 3.28e-05
|
| ARM |
smart00185 |
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ... |
494-535 |
5.22e-04 |
|
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.
Pssm-ID: 214547 [Multi-domain] Cd Length: 41 Bit Score: 39.72 E-value: 5.22e-04
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 306922386 494 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLSW 535
Cdd:smart00185 1 DDENKQAVVDA-GGLPALVELLKSEDEEVVKEAAWALSNLSS 41
|
|
| Arm |
pfam00514 |
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
494-534 |
6.00e-04 |
|
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.
Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 39.36 E-value: 6.00e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 306922386 494 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLS 534
Cdd:pfam00514 1 SPENKQAVIEA-GAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
|
|
| Arm |
pfam00514 |
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
673-713 |
6.96e-04 |
|
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.
Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 39.36 E-value: 6.96e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 306922386 673 NPKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMA 713
Cdd:pfam00514 1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
|
|
| SAMP |
pfam05924 |
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1698-1719 |
1.26e-03 |
|
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.
Pssm-ID: 461782 Cd Length: 22 Bit Score: 38.34 E-value: 1.26e-03
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
1273-1683 |
3.45e-03 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 43.14 E-value: 3.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 1273 QTTQEAD---SANTLQIAEIKEKIGTRSAEDPvsEVPAVSQHPRTKSSRLQGSSLSSESARHKAVEFSSGAKSPSKSGAQ 1349
Cdd:PTZ00449 480 QFTQEIKkliKKSKKKLAPIEEEDSDKHDEPP--EGPEASGLPPKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEV 557
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 1350 TPKSPP--EHYVQETPLMFSRCT----SVSSLDSFESRSIASSVQ-SEPCSGMVSGIISPSDLPDSPGQTMPPSRSKTPP 1422
Cdd:PTZ00449 558 GKKPGPakEHKPSKIPTLSKKPEfpkdPKHPKDPEEPKKPKRPRSaQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPP 637
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 1423 PPPQTAQTKR-EVPK----NKAPTAEKRESGPK------QAAVNAAVQRVQvlpdadtllhfaTESTPDGFSCSSSLSAL 1491
Cdd:PTZ00449 638 PPQRPSSPERpEGPKiiksPKPPKSPKPPFDPKfkekfyDDYLDAAAKSKE------------TKTTVVLDESFESILKE 705
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 1492 SLDEPFIQKDVELRIMPPVQENDNG------NETESEQPKESNENQEKEAEKTIDSEKDLLDDSDDDDIEILEECIISAM 1565
Cdd:PTZ00449 706 TLPETPGTPFTTPRPLPPKLPRDEEfpfepiGDPDAEQPDDIEFFTPPEEERTFFHETPADTPLPDILAEEFKEEDIHAE 785
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 1566 PTKSSRKAKKPAQTASKLPPPVARKPSqlpvyklLPSQNRLQPQKHVSFTPGDDMPRVYCVE--GTPINFSTATSLSDL- 1642
Cdd:PTZ00449 786 TGEPDEAMKRPDSPSEHEDKPPGDHPS-------LPKKRHRLDGLALSTTDLESDAGRIAKDasGKIVKLKRSKSFDDLt 858
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 306922386 1643 TIESPPNELAAGEGVRGGAQSGEFEKRDTIPTEGRSTDEAQ 1683
Cdd:PTZ00449 859 TVEEAEEMGAEARKIVVDDDGTEADDEDTHPPEEKHKSEVR 899
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1353-1375 |
3.95e-03 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
Pssm-ID: 461781 Cd Length: 24 Bit Score: 36.97 E-value: 3.95e-03
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1239-1256 |
7.34e-03 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
Pssm-ID: 461781 Cd Length: 24 Bit Score: 36.20 E-value: 7.34e-03
|
| ARM |
smart00185 |
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ... |
322-374 |
8.05e-03 |
|
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.
Pssm-ID: 214547 [Multi-domain] Cd Length: 41 Bit Score: 36.25 E-value: 8.05e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 306922386 322 SQDSCISMRQSGCLPLLIQLLHgndkdsvllgnsRGSKEARARASAALHNIIH 374
Cdd:smart00185 1 DDENKQAVVDAGGLPALVELLK------------SEDEEVVKEAAWALSNLSS 41
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Arm_APC_u3 |
pfam16629 |
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ... |
714-1001 |
1.22e-166 |
|
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
Pssm-ID: 435476 Cd Length: 293 Bit Score: 515.29 E-value: 1.22e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 714 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRSKQRHKQSLYGDYVFDTNRHDDN-- 791
Cdd:pfam16629 1 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNVYSEYVLDSGRHDDSvc 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 792 RSDNFNTGNMTVLSPYLNTTVLPSSSSSRG--SLDSSRSEKDRSLERERGIGLGNYHPATENPGTSSKR-GLQISTTAAQ 868
Cdd:pfam16629 81 RSDNFNTGNVTVLSPYLNTTVLPSSSSRDSrgNAESSRSEKDRSLDRERGAGLSNFHPATENSGNSSKRiGMQISTTAAQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 869 IAKVMEEVSAIHTSQEDRSSGSTTELHCVTDERNALRRSSAAHTHSNTYNFTKSENSNRTCSMPYAKLEYKRSSNDSLNS 948
Cdd:pfam16629 161 IAKVMEEVSSMHISQEDRSSGSTSDMHCMQDDRNSIRRSSTAHPHSNVYSFNKSESSNRPCPMPYMKMEYKRASNDSLNS 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 306922386 949 VSSSDGYGKRGQMKPSIESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDG 1001
Cdd:pfam16629 241 VSSSDGYGKRGQMKPSVESYSEDDEGKFCSYGKYPADLAHKIHSANHMDDNDG 293
|
|
| APC_basic |
pfam05956 |
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ... |
2205-2550 |
9.08e-109 |
|
APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.
Pssm-ID: 428690 [Multi-domain] Cd Length: 336 Bit Score: 351.10 E-value: 9.08e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2205 SISRGRTMIHIPGVRNSSSSTSPVSKKGPPLKTPASKSPSEGQTATTS-PRGAKPSVKSELSPVARQTSQIGGSSKAPSR 2283
Cdd:pfam05956 1 VVFRGRTVIYMPGVKESQPSTSPPPKKTPPKTDAPAKNPNLGQQRSRSlHRLGKPSELADLSPPKRSATPPARISKAPSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2284 SGSRDSTPSRPAQQPLSRPIQSPGRNSISPGRNgisppnKLSQLPRTSSPSTASTKSSGSgKMSYTSPGRQMSQQNLTKQ 2363
Cdd:pfam05956 81 GSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGRN------KLSPLPKTKSPARASTKKSGS-HKTQKSPVRIPFMQTPTKQ 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2364 TGLSKNASSI------PRSESASKGLNqmnngNGANKKVELSRMSSTKSSGSESDRSerpVLVRQSTFIKEAPSPTLRRK 2437
Cdd:pfam05956 154 TGLPRNPSPLvtnqpePRSESASKGLR-----SLPGKRLDLVRMSSARSSGSESDRS---GFLRQLTFIKESPSLLLRRR 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2438 LEESASfESLSPSSRPASPTRSQaqtpvlsPSLPDMSLSTHSSVQAGGWRKLPPNLSPTIEYNDGRPAKRHDIARSHSES 2517
Cdd:pfam05956 226 LELSAS-ESLSPSSQPASPRRSR-------PGLPAVFLCSSRCQELKGWRKQPPNPNSRAEPSDRPLTRRRPPRRTSSES 297
|
330 340 350
....*....|....*....|....*....|...
gi 306922386 2518 PSRLPInRSGTWKREHSKHSSSLPRVSTWRRTG 2550
Cdd:pfam05956 298 PSRLPV-RNGTWKRETFKRYSSLPHINVWRRTG 329
|
|
| EB1_binding |
pfam05937 |
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the ... |
2652-2825 |
1.90e-89 |
|
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the microtubule-associating protein EB-1. At the C-terminus of the alignment is also a pfam00595 binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins.
Pssm-ID: 399141 Cd Length: 174 Bit Score: 288.82 E-value: 1.90e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2652 RSGRSPTGNTPPVIDSVSEKANPNIKDSKDNQAKQNVGNGSVPMRTVGLENRLNSFIQVDAPDQKGTEIKPGQNNPVPVS 2731
Cdd:pfam05937 1 RSGRSPTGNTPPVIDSVPEKGIKDEKDSKDPQAKQNMGNGNVPVRTVGLENRLNSFIQSDSPDKKGTETKPLQNNPVPTP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2732 ETNESSIVERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVNNNTKKRDSKTDSTESSGTQ 2811
Cdd:pfam05937 81 ETNENPVSERTPFSSSSSSKHSSPSGAVAARVTPFNYNPSPRKSSADSSSARPSQIPTPVNNSTKKRDSKTESTDSSGNQ 160
|
170
....*....|....
gi 306922386 2812 SPKRHSGSYLVTSV 2825
Cdd:pfam05937 161 SPKRHSGSYLVTSV 174
|
|
| APC_u5 |
pfam16630 |
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of ... |
1018-1117 |
8.98e-57 |
|
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of natively unstructured sequence lying between the first and the second 15-residue beta-catenin binding motifs, APC_15aa, pfam05972, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
Pssm-ID: 406923 Cd Length: 100 Bit Score: 192.04 E-value: 8.98e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 1018 LNSGRQSPSQNERWARPKHIIEDEIKQSEQRQSRNQSTTYPVYTESTDDKHLKFQPHFGQQECVSPYRSRGANGSETNRV 1097
Cdd:pfam16630 1 LNSGRQSPSQNERWARPKHIIEDEMKQSEQRQPRSQSTTYPVYTESGDDKHMKFQPRFGQQECVSPFRSRGSNGSEQSRV 80
|
90 100
....*....|....*....|
gi 306922386 1098 GSNHGINQNVSQSLCQEDDY 1117
Cdd:pfam16630 81 GSSHGINQKVSQSLCQVDDY 100
|
|
| APC_u14 |
pfam16635 |
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively ... |
1728-1821 |
4.16e-47 |
|
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively unstructured sequence lying between the second SAMP pfam05924, and the fifth creatine-rich region, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
Pssm-ID: 435479 Cd Length: 94 Bit Score: 164.24 E-value: 4.16e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 1728 IMDQVQQASASSSAPNKNQLDGKKKKPTSPVKPIPQNTEYRTRVRKNADSKNNLNAERVFSDNKDSKKQNLKNNSKVFND 1807
Cdd:pfam16635 1 IMDQIQQASAASSGGSKSQQDGEKKKPTSPVKPMPQSSEYRARVRKNTESKNNLNSERSYPDNKESKKQNLKNNSRDFND 80
|
90
....*....|....
gi 306922386 1808 KLPNNEDRVRGSFA 1821
Cdd:pfam16635 81 KLPNNEERTRGSFA 94
|
|
| APC_rep |
pfam18797 |
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ... |
375-448 |
3.50e-45 |
|
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.
Pssm-ID: 465870 Cd Length: 74 Bit Score: 158.09 E-value: 3.50e-45
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 306922386 375 SQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAVCVLMKLSFDEEHRHAM 448
Cdd:pfam18797 1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
|
|
| APC_u9 |
pfam16633 |
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of ... |
1265-1350 |
1.64e-35 |
|
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of natively unstructured sequence lying between the first and second APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
Pssm-ID: 435478 Cd Length: 89 Bit Score: 131.15 E-value: 1.64e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 1265 AEDEI-GCNQTTQEADSANTLQIAEIKEKIGTRSAEDPVSEVPAVSQHPRTKSSRLQGSSLS-SESARHKAVEFSSGAKS 1342
Cdd:pfam16633 2 AEDEIeGRDQATRSTDNYNTLQITELKENSGAVSTEQTVSEVPSSSQHIRTKPNRLQASNLSpSDSSRHKAVEFSSGAKS 81
|
....*...
gi 306922386 1343 PSKSGAQT 1350
Cdd:pfam16633 82 PSKSGAQT 89
|
|
| APC_u15 |
pfam16636 |
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of ... |
1855-1929 |
2.14e-31 |
|
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of natively unstructured sequence lying between the fifth and sixth creatine-rich, APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
Pssm-ID: 435480 Cd Length: 81 Bit Score: 118.81 E-value: 2.14e-31
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 306922386 1855 DLSREKAELRKAKENKESEAKVTSHTELTSNQQSANKTQAIAKQPINRGQPKPILQKQSTFPQSSKDIPDRGAAT 1929
Cdd:pfam16636 7 DLSREKAELRKGKETKETETKVTSHIEQPSNQQSTNRTQACQKHPPNRGQPKPLLQKQTTFPQSSKDIPDRGAAT 81
|
|
| APC_u13 |
pfam16634 |
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively ... |
1644-1697 |
1.18e-24 |
|
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively unstructured sequence lying between the fourth creatine-rich region, APC_crr, pfam05923, and the SAMP pfam05924, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.
Pssm-ID: 406927 Cd Length: 54 Bit Score: 98.71 E-value: 1.18e-24
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 306922386 1644 IESPPNELAAGEGVRGGAQSGEFEKRDTIPTEGRSTDEAQGGKTSSVTIPELDD 1697
Cdd:pfam16634 1 IESPPNELANAESTGTGAESAEFEKRDTIPTEGRSTDDAQRGKKSNITTSALDD 54
|
|
| Suppressor_APC |
pfam11414 |
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ... |
137-217 |
1.81e-22 |
|
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.
Pssm-ID: 463275 Cd Length: 82 Bit Score: 93.47 E-value: 1.81e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 137 SRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTE-NFSLQTDMTRRQLEYEARQIRVAMEEQLG 215
Cdd:pfam11414 1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGtYFDYGSDAQQERLEFLLARIQEVNRCLGG 80
|
..
gi 306922386 216 TC 217
Cdd:pfam11414 81 LI 82
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1619-1642 |
1.71e-07 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
Pssm-ID: 461781 Cd Length: 24 Bit Score: 49.30 E-value: 1.71e-07
|
| ARM |
smart00185 |
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ... |
631-671 |
4.58e-07 |
|
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.
Pssm-ID: 214547 [Multi-domain] Cd Length: 41 Bit Score: 48.19 E-value: 4.58e-07
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 306922386 631 NEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSA 671
Cdd:smart00185 1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
|
|
| Arm |
pfam00514 |
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
631-671 |
6.22e-07 |
|
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.
Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 47.83 E-value: 6.22e-07
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 306922386 631 NEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSA 671
Cdd:pfam00514 1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
2233-2546 |
1.35e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 54.56 E-value: 1.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2233 PPLKTPASKsPSEGQTATTSPRGAKPSVKSE----LSPVARQTSQIGGSSKAPSRSGSRDSTPSRPAQQPLSRPIQSPGR 2308
Cdd:PHA03247 2703 PPPPTPEPA-PHALVSATPLPPGPAAARQASpalpAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR 2781
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2309 NSISPGRNGISPPNKLSQLPRTSSPSTASTKSSGSGKMSYTSPGrqmsqqnltkqTGLSKNASSIPRSESASKGLNQ--M 2386
Cdd:PHA03247 2782 RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPA-----------GPLPPPTSAQPTAPPPPPGPPPpsL 2850
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2387 NNGNGANKKVELSRMSSTKSSGSESDRSERPVLVRqstfikeAPSPTLRRKLEESA-SFESLSPSSRPASPTRSQAQTPV 2465
Cdd:PHA03247 2851 PLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRR-------LARPAVSRSTESFAlPPDQPERPPQPQAPPPPQPQPQP 2923
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2466 LSPSLPDMSLSTHSSVQAggwrKLPPNLSPTieyNDGRPAKRHDIARSHSESPSRLPINRSGTWK----RE------HSK 2535
Cdd:PHA03247 2924 PPPPQPQPPPPPPPRPQP----PLAPTTDPA---GAGEPSGAVPQPWLGALVPGRVAVPRFRVPQpapsREapasstPPL 2996
|
330
....*....|.
gi 306922386 2536 HSSSLPRVSTW 2546
Cdd:PHA03247 2997 TGHSLSRVSSW 3007
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
2238-2383 |
8.92e-06 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 51.71 E-value: 8.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2238 PASKSPSEGQTATTSPRGAKPSVKSELSPVA----RQTSQIGGSSKAPSRSGSRDSTPSRPAQQPLSRPIQSPGRNSISP 2313
Cdd:PHA03307 278 PSSRPGPASSSSSPRERSPSPSPSSPGSGPApsspRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPP 357
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2314 GRNGISPPNKLSQlPRTSSPSTASTKSSGSGKMSYTSPGRQMSQQNLTKQTGLSKNASSIPRSESASKGL 2383
Cdd:PHA03307 358 PPADPSSPRKRPR-PSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAGAASGAF 426
|
|
| SAMP |
pfam05924 |
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ... |
2015-2034 |
3.28e-05 |
|
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.
Pssm-ID: 461782 Cd Length: 22 Bit Score: 42.58 E-value: 3.28e-05
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
2231-2526 |
6.50e-05 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 48.63 E-value: 6.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2231 KGPPLKTPASKSPSEGQTATTSPRGAKPSVKSELSPVARQTSQIGGSSKAPSRSGSRDSTPSRPAQQP---LSRPIQSPG 2307
Cdd:PHA03307 101 AREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASsrqAALPLSSPE 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2308 RNSISPGRNGISPPNKLSQLPRTSSP----STASTKSSGSGKMSYTSPGRQMSQQNLTKQTGLSKNASSIPRSE----SA 2379
Cdd:PHA03307 181 ETARAPSSPPAEPPPSTPPAAASPRPprrsSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENEcplpRP 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2380 SKGLNQMNNGNGANKKVELSRMSSTKSSGSESDRSERPVLVRQStfiKEAPSPTLRRKLEESASFESLSPSSRPASPTRS 2459
Cdd:PHA03307 261 APITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPG---SGPAPSSPRASSSSSSSRESSSSSTSSSSESSR 337
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 306922386 2460 QAQTPVLSPSLPDMSLSTHSSVQAGGWRKLPPNLSPTIEY---NDGRP---AKRHDIARSH--SESPSRLPINRS 2526
Cdd:PHA03307 338 GAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSpaaSAGRPtrrRARAAVAGRArrRDATGRFPAGRP 412
|
|
| ARM |
smart00185 |
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ... |
494-535 |
5.22e-04 |
|
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.
Pssm-ID: 214547 [Multi-domain] Cd Length: 41 Bit Score: 39.72 E-value: 5.22e-04
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 306922386 494 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLSW 535
Cdd:smart00185 1 DDENKQAVVDA-GGLPALVELLKSEDEEVVKEAAWALSNLSS 41
|
|
| Arm |
pfam00514 |
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
494-534 |
6.00e-04 |
|
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.
Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 39.36 E-value: 6.00e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 306922386 494 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLS 534
Cdd:pfam00514 1 SPENKQAVIEA-GAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
|
|
| Arm |
pfam00514 |
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
673-713 |
6.96e-04 |
|
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.
Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 39.36 E-value: 6.96e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 306922386 673 NPKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMA 713
Cdd:pfam00514 1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
2236-2496 |
1.12e-03 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 44.18 E-value: 1.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2236 KTPASKSPSEGQTATTSPRGAKPsvkselSPVARQTSQIGGSSKAPSRSGSRDSTPSRPAQQPLSRPIQSPGRNSISPgr 2315
Cdd:pfam17823 151 RANASAAPRAAIAAASAPHAASP------APRTAASSTTAASSTTAASSAPTTAASSAPATLTPARGISTAATATGHP-- 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2316 ngiSPPNKLSQLPrTSSPStASTKSSGSGKMSYTSPGRQMSQQNLTKQTGLSKNASSiPRSESASKGLNQMNNGNGANKk 2395
Cdd:pfam17823 223 ---AAGTALAAVG-NSSPA-AGTVTAAVGTVTPAALATLAAAAGTVASAAGTINMGD-PHARRLSPAKHMPSDTMARNP- 295
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2396 veLSRMSSTKSSGSESDRSERPVLvrqSTFIKEAPSPTlRRKLEESASFESLSPSSRPASPTRSQAQTPVLSPsLPDMSL 2475
Cdd:pfam17823 296 --AAPMGAQAQGPIIQVSTDQPVH---NTAGEPTPSPS-NTTLEPNTPKSVASTNLAVVTTTKAQAKEPSASP-VPVLHT 368
|
250 260
....*....|....*....|.
gi 306922386 2476 STHSSVQAGGWRKLPPNLSPT 2496
Cdd:pfam17823 369 SMIPEVEATSPTTQPSPLLPT 389
|
|
| SAMP |
pfam05924 |
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1698-1719 |
1.26e-03 |
|
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.
Pssm-ID: 461782 Cd Length: 22 Bit Score: 38.34 E-value: 1.26e-03
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
1273-1683 |
3.45e-03 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 43.14 E-value: 3.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 1273 QTTQEAD---SANTLQIAEIKEKIGTRSAEDPvsEVPAVSQHPRTKSSRLQGSSLSSESARHKAVEFSSGAKSPSKSGAQ 1349
Cdd:PTZ00449 480 QFTQEIKkliKKSKKKLAPIEEEDSDKHDEPP--EGPEASGLPPKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEV 557
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 1350 TPKSPP--EHYVQETPLMFSRCT----SVSSLDSFESRSIASSVQ-SEPCSGMVSGIISPSDLPDSPGQTMPPSRSKTPP 1422
Cdd:PTZ00449 558 GKKPGPakEHKPSKIPTLSKKPEfpkdPKHPKDPEEPKKPKRPRSaQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPP 637
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 1423 PPPQTAQTKR-EVPK----NKAPTAEKRESGPK------QAAVNAAVQRVQvlpdadtllhfaTESTPDGFSCSSSLSAL 1491
Cdd:PTZ00449 638 PPQRPSSPERpEGPKiiksPKPPKSPKPPFDPKfkekfyDDYLDAAAKSKE------------TKTTVVLDESFESILKE 705
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 1492 SLDEPFIQKDVELRIMPPVQENDNG------NETESEQPKESNENQEKEAEKTIDSEKDLLDDSDDDDIEILEECIISAM 1565
Cdd:PTZ00449 706 TLPETPGTPFTTPRPLPPKLPRDEEfpfepiGDPDAEQPDDIEFFTPPEEERTFFHETPADTPLPDILAEEFKEEDIHAE 785
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 1566 PTKSSRKAKKPAQTASKLPPPVARKPSqlpvyklLPSQNRLQPQKHVSFTPGDDMPRVYCVE--GTPINFSTATSLSDL- 1642
Cdd:PTZ00449 786 TGEPDEAMKRPDSPSEHEDKPPGDHPS-------LPKKRHRLDGLALSTTDLESDAGRIAKDasGKIVKLKRSKSFDDLt 858
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 306922386 1643 TIESPPNELAAGEGVRGGAQSGEFEKRDTIPTEGRSTDEAQ 1683
Cdd:PTZ00449 859 TVEEAEEMGAEARKIVVDDDGTEADDEDTHPPEEKHKSEVR 899
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1353-1375 |
3.95e-03 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
Pssm-ID: 461781 Cd Length: 24 Bit Score: 36.97 E-value: 3.95e-03
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
2234-2550 |
6.17e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 42.47 E-value: 6.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2234 PLKTPASKSPSEGQTATTSPRGAKPSVKSELSPVARQTSQiGGSSKAPSRSGsrDSTPSRPAQQPLSRPIQSPGRNSISP 2313
Cdd:PHA03307 63 DRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAR-EGSPTPPGPSS--PDPPPPTPPPASPPPSPAPDLSEMLR 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2314 GRNGISPPNKLSQLPRTSSPS-TASTKSSGSGKM---------SYTSPGRQMSQQNLTKQTGLSKNASSIPRSESASKGL 2383
Cdd:PHA03307 140 PVGSPGPPPAASPPAAGASPAaVASDAASSRQAAlplsspeetARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASS 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2384 NQMNNGNGANKKVELSRMSSTKSSGSESD---RSERPVLVRQSTfikeaPSPTLRRKLEESASFESLSPSSRPASPTRSQ 2460
Cdd:PHA03307 220 PAPAPGRSAADDAGASSSDSSSSESSGCGwgpENECPLPRPAPI-----TLPTRIWEASGWNGPSSRPGPASSSSSPRER 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2461 AqtPVLSPSLPDMSLSTHSSVQAGGWRKLPP-NLSPTIEYNDGRPAKRHDIARSHSESPS----RLPINRSGTWKREHSK 2535
Cdd:PHA03307 295 S--PSPSPSSPGSGPAPSSPRASSSSSSSREsSSSSTSSSSESSRGAAVSPGPSPSRSPSpsrpPPPADPSSPRKRPRPS 372
|
330
....*....|....*
gi 306922386 2536 HSSSLPRVSTWRRTG 2550
Cdd:PHA03307 373 RAPSSPAASAGRPTR 387
|
|
| APC_r |
pfam05923 |
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ... |
1239-1256 |
7.34e-03 |
|
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.
Pssm-ID: 461781 Cd Length: 24 Bit Score: 36.20 E-value: 7.34e-03
|
| ARM |
smart00185 |
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ... |
322-374 |
8.05e-03 |
|
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.
Pssm-ID: 214547 [Multi-domain] Cd Length: 41 Bit Score: 36.25 E-value: 8.05e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 306922386 322 SQDSCISMRQSGCLPLLIQLLHgndkdsvllgnsRGSKEARARASAALHNIIH 374
Cdd:smart00185 1 DDENKQAVVDAGGLPALVELLK------------SEDEEVVKEAAWALSNLSS 41
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
2232-2522 |
8.65e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 41.85 E-value: 8.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2232 GPPLKTPASKSPSEGQTATTSPRGAKPSvkselsPVARQTSqIGGSSKAPSRSGSRDSTPSRPAQQPLSRPIQSPGRNSI 2311
Cdd:PHA03247 2603 DDRGDPRGPAPPSPLPPDTHAPDPPPPS------PSPAANE-PDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQ 2675
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2312 SPgrngiSPPNKLSQ--LPRTSSPSTASTKSSGSGKMSYTSPGRQMSQQNLTKQTGLSKNASSIPRSESASKGLNQMNNG 2389
Cdd:PHA03247 2676 AS-----SPPQRPRRraARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPAT 2750
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306922386 2390 NGANKKVE--------LSRMSSTKSSGSESDRSERPVLVRQSTFIKEAPSPT--LRRKLEESASFESLSPSSRPAS---- 2455
Cdd:PHA03247 2751 PGGPARPArppttagpPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWdpADPPAAVLAPAAALPPAASPAGplpp 2830
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 306922386 2456 PTRSQAQTPVLSPSLPDMSLSTHSSVQAGG--WRKLPPNLSPTIEYNDGRPAKRHDIARSHSESPSRLP 2522
Cdd:PHA03247 2831 PTSAQPTAPPPPPGPPPPSLPLGGSVAPGGdvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFA 2899
|
|
| |
