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Conserved domains on  [gi|188528698|ref|NP_001120870|]
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endoplasmic reticulum lectin 1 isoform 3 precursor [Homo sapiens]

Protein Classification

endoplasmic reticulum lectin 1( domain architecture ID 10546084)

endoplasmic reticulum lectin 1 may function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins

CATH:  2.70.130.10
Gene Ontology:  GO:0051082|GO:0030968

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRKCSH pfam07915
Glucosidase II beta subunit-like protein; The sequences found in this family are similar to a ...
 294-367 2.44e-17

Glucosidase II beta subunit-like protein; The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II, which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyzes the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum. Mutations in the gene coding for PRKCSH have been found to be involved in the development of autosomal dominant polycystic liver disease (ADPLD), but the precise role the protein has in the pathogenesis of this disease is unknown. This family also includes an ER sensor for misfolded glycoproteins and is therefore likely to be a generic sugar binding domain.


:

Pssm-ID: 400321  Cd Length: 72  Bit Score: 76.04  E-value: 2.44e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 188528698  294 GVGWWKYEFCYGKHVHQYHEDKDSGKTSVVVGTWnqeEHIEWAKKNTArayhlQDDGTQTVRMVSHFYGNGDIC 367
Cdd:pfam07915   7 DEGEWTYEFCFGKHVRQFHKGQEKGGSSFSLGRF---SESSWAESTYD-----DEWTKGSNRYISMIYGNGTKC 72
PRKCSH pfam07915
Glucosidase II beta subunit-like protein; The sequences found in this family are similar to a ...
 111-199 2.64e-17

Glucosidase II beta subunit-like protein; The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II, which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyzes the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum. Mutations in the gene coding for PRKCSH have been found to be involved in the development of autosomal dominant polycystic liver disease (ADPLD), but the precise role the protein has in the pathogenesis of this disease is unknown. This family also includes an ER sensor for misfolded glycoproteins and is therefore likely to be a generic sugar binding domain.


:

Pssm-ID: 400321  Cd Length: 72  Bit Score: 76.04  E-value: 2.64e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188528698  111 SSCSYRIESYWTYEVCHGKHIRQYHEEketgQKINIHEYYLGNMLAKnllfekereaeekEKSNEIPTKNIEGQMTPYYP 190
Cdd:pfam07915   1 GKCFYYDEGEWTYEFCFGKHVRQFHKG----QEKGGSSFSLGRFSES-------------SWAESTYDDEWTKGSNRYIS 63


                  ....*....
gi 188528698  191 VGMGNGTPC 199
Cdd:pfam07915  64 MIYGNGTKC 72
PRKCSH super family cl06793
Glucosidase II beta subunit-like protein; The sequences found in this family are similar to a ...
 206-250 2.35e-03

Glucosidase II beta subunit-like protein; The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II, which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyzes the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum. Mutations in the gene coding for PRKCSH have been found to be involved in the development of autosomal dominant polycystic liver disease (ADPLD), but the precise role the protein has in the pathogenesis of this disease is unknown. This family also includes an ER sensor for misfolded glycoproteins and is therefore likely to be a generic sugar binding domain.


The actual alignment was detected with superfamily member pfam13015:

Pssm-ID: 414904  Cd Length: 154  Bit Score: 38.28  E-value: 2.35e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 188528698  206 PRSSTVMYICHPESkhEILSVAEVTTCEYEVVILTPLLCSHPKYR 250
Cdd:pfam13015  92 HRSAIVEVECGDVN--ELVSVSEPEKCEYLFVVKSPAACSNVYLV 134
 
Name Accession Description Interval E-value
PRKCSH pfam07915
Glucosidase II beta subunit-like protein; The sequences found in this family are similar to a ...
 294-367 2.44e-17

Glucosidase II beta subunit-like protein; The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II, which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyzes the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum. Mutations in the gene coding for PRKCSH have been found to be involved in the development of autosomal dominant polycystic liver disease (ADPLD), but the precise role the protein has in the pathogenesis of this disease is unknown. This family also includes an ER sensor for misfolded glycoproteins and is therefore likely to be a generic sugar binding domain.


Pssm-ID: 400321  Cd Length: 72  Bit Score: 76.04  E-value: 2.44e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 188528698  294 GVGWWKYEFCYGKHVHQYHEDKDSGKTSVVVGTWnqeEHIEWAKKNTArayhlQDDGTQTVRMVSHFYGNGDIC 367
Cdd:pfam07915   7 DEGEWTYEFCFGKHVRQFHKGQEKGGSSFSLGRF---SESSWAESTYD-----DEWTKGSNRYISMIYGNGTKC 72
PRKCSH pfam07915
Glucosidase II beta subunit-like protein; The sequences found in this family are similar to a ...
 111-199 2.64e-17

Glucosidase II beta subunit-like protein; The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II, which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyzes the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum. Mutations in the gene coding for PRKCSH have been found to be involved in the development of autosomal dominant polycystic liver disease (ADPLD), but the precise role the protein has in the pathogenesis of this disease is unknown. This family also includes an ER sensor for misfolded glycoproteins and is therefore likely to be a generic sugar binding domain.


Pssm-ID: 400321  Cd Length: 72  Bit Score: 76.04  E-value: 2.64e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188528698  111 SSCSYRIESYWTYEVCHGKHIRQYHEEketgQKINIHEYYLGNMLAKnllfekereaeekEKSNEIPTKNIEGQMTPYYP 190
Cdd:pfam07915   1 GKCFYYDEGEWTYEFCFGKHVRQFHKG----QEKGGSSFSLGRFSES-------------SWAESTYDDEWTKGSNRYIS 63


                  ....*....
gi 188528698  191 VGMGNGTPC 199
Cdd:pfam07915  64 MIYGNGTKC 72
PRKCSH_1 pfam13015
Glucosidase II beta subunit-like protein; The sequences found in this family are similar to a ...
 206-250 2.35e-03

Glucosidase II beta subunit-like protein; The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II, which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyzes the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum. The beta-subunit confers substrate specificity for di- and monoglucosylated glycans on the glucose-trimming activity of the alpha-subunit.


Pssm-ID: 404038  Cd Length: 154  Bit Score: 38.28  E-value: 2.35e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 188528698  206 PRSSTVMYICHPESkhEILSVAEVTTCEYEVVILTPLLCSHPKYR 250
Cdd:pfam13015  92 HRSAIVEVECGDVN--ELVSVSEPEKCEYLFVVKSPAACSNVYLV 134
 
Name Accession Description Interval E-value
PRKCSH pfam07915
Glucosidase II beta subunit-like protein; The sequences found in this family are similar to a ...
 294-367 2.44e-17

Glucosidase II beta subunit-like protein; The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II, which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyzes the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum. Mutations in the gene coding for PRKCSH have been found to be involved in the development of autosomal dominant polycystic liver disease (ADPLD), but the precise role the protein has in the pathogenesis of this disease is unknown. This family also includes an ER sensor for misfolded glycoproteins and is therefore likely to be a generic sugar binding domain.


Pssm-ID: 400321  Cd Length: 72  Bit Score: 76.04  E-value: 2.44e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 188528698  294 GVGWWKYEFCYGKHVHQYHEDKDSGKTSVVVGTWnqeEHIEWAKKNTArayhlQDDGTQTVRMVSHFYGNGDIC 367
Cdd:pfam07915   7 DEGEWTYEFCFGKHVRQFHKGQEKGGSSFSLGRF---SESSWAESTYD-----DEWTKGSNRYISMIYGNGTKC 72
PRKCSH pfam07915
Glucosidase II beta subunit-like protein; The sequences found in this family are similar to a ...
 111-199 2.64e-17

Glucosidase II beta subunit-like protein; The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II, which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyzes the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum. Mutations in the gene coding for PRKCSH have been found to be involved in the development of autosomal dominant polycystic liver disease (ADPLD), but the precise role the protein has in the pathogenesis of this disease is unknown. This family also includes an ER sensor for misfolded glycoproteins and is therefore likely to be a generic sugar binding domain.


Pssm-ID: 400321  Cd Length: 72  Bit Score: 76.04  E-value: 2.64e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 188528698  111 SSCSYRIESYWTYEVCHGKHIRQYHEEketgQKINIHEYYLGNMLAKnllfekereaeekEKSNEIPTKNIEGQMTPYYP 190
Cdd:pfam07915   1 GKCFYYDEGEWTYEFCFGKHVRQFHKG----QEKGGSSFSLGRFSES-------------SWAESTYDDEWTKGSNRYIS 63


                  ....*....
gi 188528698  191 VGMGNGTPC 199
Cdd:pfam07915  64 MIYGNGTKC 72
PRKCSH_1 pfam13015
Glucosidase II beta subunit-like protein; The sequences found in this family are similar to a ...
 206-250 2.35e-03

Glucosidase II beta subunit-like protein; The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II, which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyzes the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum. The beta-subunit confers substrate specificity for di- and monoglucosylated glycans on the glucose-trimming activity of the alpha-subunit.


Pssm-ID: 404038  Cd Length: 154  Bit Score: 38.28  E-value: 2.35e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 188528698  206 PRSSTVMYICHPESkhEILSVAEVTTCEYEVVILTPLLCSHPKYR 250
Cdd:pfam13015  92 HRSAIVEVECGDVN--ELVSVSEPEKCEYLFVVKSPAACSNVYLV 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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