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Conserved domains on  [gi|187607422|ref|NP_001119812|]
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protein orai-2 isoform a [Homo sapiens]

Protein Classification

orai family protein( domain architecture ID 10545216)

orai family protein similar to Drosophila melanogaster calcium release-activated calcium (CRAC) channel protein 1, also called protein orai, a CRAC channel subunit that mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Orai-1 pfam07856
Mediator of CRAC channel activity; ORAI-1 is a protein homolog of Drosophila Orai and human ...
 47-228 9.01e-91

Mediator of CRAC channel activity; ORAI-1 is a protein homolog of Drosophila Orai and human Orai1, Orai2 and Orai3. ORAI-1 GFP reporters are co- expressed with STIM-1 (ER CA(2+) sensors) in the gonad and intestine. The protein has four predicted transmembrane domains with a highly conserved region between TM2 ad TM3. This conserved domain is thought to function in channel regulation. ORAI1- related proteins are required for the production of the calcium channel, CRAC, along with STIM1-related proteins.


:

Pssm-ID: 462291  Cd Length: 168  Bit Score: 265.27  E-value: 9.01e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187607422   47 ALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETQYQYPRPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVS 126
Cdd:pfam07856   1 ELNRRDLELSRAKLKASSRTSALLAGFAMVAMVELQLDKPEDIPEGLLIAFAVCTALLVAVHLLALMISTCILPNIERVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187607422  127 NIHNLN-SISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDARRqpgpppgpgshtgwqAALVSTIIMV 205
Cdd:pfam07856  81 KSHVSEdEVEESPHRRFHRYIEDAWRFATRLGILLFLVEVALLSWIKFYDVSSPV---------------AAIVVTAILV 145

                         170       180
                  ....*....|....*....|...
gi 187607422  206 PVGLIFVVFTIHFYRSLVRHKTE 228
Cdd:pfam07856 146 PVLILFVVFAQHFYRSLVSHKYE 168
 
Name Accession Description Interval E-value
Orai-1 pfam07856
Mediator of CRAC channel activity; ORAI-1 is a protein homolog of Drosophila Orai and human ...
 47-228 9.01e-91

Mediator of CRAC channel activity; ORAI-1 is a protein homolog of Drosophila Orai and human Orai1, Orai2 and Orai3. ORAI-1 GFP reporters are co- expressed with STIM-1 (ER CA(2+) sensors) in the gonad and intestine. The protein has four predicted transmembrane domains with a highly conserved region between TM2 ad TM3. This conserved domain is thought to function in channel regulation. ORAI1- related proteins are required for the production of the calcium channel, CRAC, along with STIM1-related proteins.


Pssm-ID: 462291  Cd Length: 168  Bit Score: 265.27  E-value: 9.01e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187607422   47 ALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETQYQYPRPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVS 126
Cdd:pfam07856   1 ELNRRDLELSRAKLKASSRTSALLAGFAMVAMVELQLDKPEDIPEGLLIAFAVCTALLVAVHLLALMISTCILPNIERVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187607422  127 NIHNLN-SISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDARRqpgpppgpgshtgwqAALVSTIIMV 205
Cdd:pfam07856  81 KSHVSEdEVEESPHRRFHRYIEDAWRFATRLGILLFLVEVALLSWIKFYDVSSPV---------------AAIVVTAILV 145

                         170       180
                  ....*....|....*....|...
gi 187607422  206 PVGLIFVVFTIHFYRSLVRHKTE 228
Cdd:pfam07856 146 PVLILFVVFAQHFYRSLVSHKYE 168
 
Name Accession Description Interval E-value
Orai-1 pfam07856
Mediator of CRAC channel activity; ORAI-1 is a protein homolog of Drosophila Orai and human ...
 47-228 9.01e-91

Mediator of CRAC channel activity; ORAI-1 is a protein homolog of Drosophila Orai and human Orai1, Orai2 and Orai3. ORAI-1 GFP reporters are co- expressed with STIM-1 (ER CA(2+) sensors) in the gonad and intestine. The protein has four predicted transmembrane domains with a highly conserved region between TM2 ad TM3. This conserved domain is thought to function in channel regulation. ORAI1- related proteins are required for the production of the calcium channel, CRAC, along with STIM1-related proteins.


Pssm-ID: 462291  Cd Length: 168  Bit Score: 265.27  E-value: 9.01e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187607422   47 ALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETQYQYPRPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVS 126
Cdd:pfam07856   1 ELNRRDLELSRAKLKASSRTSALLAGFAMVAMVELQLDKPEDIPEGLLIAFAVCTALLVAVHLLALMISTCILPNIERVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187607422  127 NIHNLN-SISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDARRqpgpppgpgshtgwqAALVSTIIMV 205
Cdd:pfam07856  81 KSHVSEdEVEESPHRRFHRYIEDAWRFATRLGILLFLVEVALLSWIKFYDVSSPV---------------AAIVVTAILV 145

                         170       180
                  ....*....|....*....|...
gi 187607422  206 PVGLIFVVFTIHFYRSLVRHKTE 228
Cdd:pfam07856 146 PVLILFVVFAQHFYRSLVSHKYE 168
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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