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Conserved domains on  [gi|165932385|ref|NP_001107039|]
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leucine-rich repeat-containing protein 75A isoform 1 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1001123)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; similar to Oryctolagus cuniculus monocyte differentiation antigen CD14, a coreceptor for bacterial lipopolysaccharide

Gene Ontology:  GO:0005515
PubMed:  11751054

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
177-287 1.17e-04

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.77  E-value: 1.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165932385 177 TVDLSGIPLTS--RDLERVTSyLQrcgeqvdSVELGFTGLTDdmvlqLLPALSTLPRLTTLALNGNRLTravlrDLTDIL 254
Cdd:COG4886  117 SLDLSGNQLTDlpEELANLTN-LK-------ELDLSNNQLTD-----LPEPLGNLTNLKSLDLSNNQLT-----DLPEEL 178

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 165932385 255 kdpSKFPNVTWIDLGNNvDIFSLPQPF--LLSLRK 287
Cdd:COG4886  179 ---GNLTNLKELDLSNN-QITDLPEPLgnLTNLEE 209
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
177-287 1.17e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.77  E-value: 1.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165932385 177 TVDLSGIPLTS--RDLERVTSyLQrcgeqvdSVELGFTGLTDdmvlqLLPALSTLPRLTTLALNGNRLTravlrDLTDIL 254
Cdd:COG4886  117 SLDLSGNQLTDlpEELANLTN-LK-------ELDLSNNQLTD-----LPEPLGNLTNLKSLDLSNNQLT-----DLPEEL 178

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 165932385 255 kdpSKFPNVTWIDLGNNvDIFSLPQPF--LLSLRK 287
Cdd:COG4886  179 ---GNLTNLKELDLSNN-QITDLPEPLgnLTNLEE 209
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 169-265 1.18e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.42  E-value: 1.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165932385 169 LAGSPPDN----TVDLSGIPLTSRDLERVTSYLQRCGEQVDSVELGFTGLTDDMVLQLLPALSTLPRLTTLALNGNRLTR 244
Cdd:cd00116  213 LAETLASLksleVLNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGE 292

                         90       100
                 ....*....|....*....|.
gi 165932385 245 AVLRDLTDILKDPSKFPNVTW 265
Cdd:cd00116  293 EGAQLLAESLLEPGNELESLW 313
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
177-287 1.17e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.77  E-value: 1.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165932385 177 TVDLSGIPLTS--RDLERVTSyLQrcgeqvdSVELGFTGLTDdmvlqLLPALSTLPRLTTLALNGNRLTravlrDLTDIL 254
Cdd:COG4886  117 SLDLSGNQLTDlpEELANLTN-LK-------ELDLSNNQLTD-----LPEPLGNLTNLKSLDLSNNQLT-----DLPEEL 178

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 165932385 255 kdpSKFPNVTWIDLGNNvDIFSLPQPF--LLSLRK 287
Cdd:COG4886  179 ---GNLTNLKELDLSNN-QITDLPEPLgnLTNLEE 209
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 165-271 1.61e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 43.24  E-value: 1.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165932385 165 LKAVLAGSPPDNTVDLSGIPLTSRDLERVTSYLQRcGEQVDSVELGFTGLTDDMVLQLLPALSTLPRLTTLALNGNRLTR 244
Cdd:COG5238  200 LAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKG-NKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGA 278

                         90       100
                 ....*....|....*....|....*..
gi 165932385 245 AVLRDLTDILKDPskfPNVTWIDLGNN 271
Cdd:COG5238  279 EGAIALAKALQGN---TTLTSLDLSVN 302
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
177-271 2.14e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.00  E-value: 2.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165932385 177 TVDLSGIPLTS--RDLERVTSyLQrcgeqvdSVELGFTGLTDdmvlqlLPALSTLPRLTTLALNGNRLTRavlrdltdiL 254
Cdd:COG4886  209 ELDLSGNQLTDlpEPLANLTN-LE-------TLDLSNNQLTD------LPELGNLTNLEELDLSNNQLTD---------L 265

                         90
                 ....*....|....*..
gi 165932385 255 KDPSKFPNVTWIDLGNN 271
Cdd:COG4886  266 PPLANLTNLKTLDLSNN 282
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 169-265 1.18e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.42  E-value: 1.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 165932385 169 LAGSPPDN----TVDLSGIPLTSRDLERVTSYLQRCGEQVDSVELGFTGLTDDMVLQLLPALSTLPRLTTLALNGNRLTR 244
Cdd:cd00116  213 LAETLASLksleVLNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGE 292

                         90       100
                 ....*....|....*....|.
gi 165932385 245 AVLRDLTDILKDPSKFPNVTW 265
Cdd:cd00116  293 EGAQLLAESLLEPGNELESLW 313
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
209-279 1.84e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.92  E-value: 1.84e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 165932385 209 LGFTGLTDdmvlqlLP-ALSTLPRLTTLALNGNRLTravlrDLTDILkdpSKFPNVTWIDLGNNvDIFSLPQ 279
Cdd:COG4886  189 LSNNQITD------LPePLGNLTNLEELDLSGNQLT-----DLPEPL---ANLTNLETLDLSNN-QLTDLPE 245
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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