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ankyrin repeat and SOCS box protein 11 [Rattus norvegicus]

Protein Classification

ankyrin repeat and SOCS box protein( domain architecture ID 1562964)

ankyrin repeat and SOCS box protein (ASB) may be a substrate-recognition component of an SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Gene Ontology:  GO:0016567|GO:0005515
PubMed:  17176038|18948053|12076535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
35-251 4.20e-34

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 125.45  E-value: 4.20e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743  35 ADRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNACCSGS 114
Cdd:COG0666   53 LGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGN 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743 115 AACVNVLLEFGAKA-QLEVYLASPIHEAVKRGHRECMEILLANNVNIEQEIPQLGTPLYVACTYQRVDCVKKLLELGASV 193
Cdd:COG0666  133 LEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADV 212

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 157819743 194 DH-GRWLDTPLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELAAPKSSVEQALLL 251
Cdd:COG0666  213 NAkDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLL 271
SOCS super family cl02533
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 253-294 2.20e-16

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


The actual alignment was detected with superfamily member cd03728:

Pssm-ID: 470605  Cd Length: 42  Bit Score: 71.36  E-value: 2.20e-16
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 157819743 253 EGPPALSQLCRLCVRKCLGRTCHQAIYALGLPEPLEKFLLYQ 294
Cdd:cd03728    1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
35-251 4.20e-34

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 125.45  E-value: 4.20e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743  35 ADRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNACCSGS 114
Cdd:COG0666   53 LGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGN 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743 115 AACVNVLLEFGAKA-QLEVYLASPIHEAVKRGHRECMEILLANNVNIEQEIPQLGTPLYVACTYQRVDCVKKLLELGASV 193
Cdd:COG0666  133 LEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADV 212

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 157819743 194 DH-GRWLDTPLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELAAPKSSVEQALLL 251
Cdd:COG0666  213 NAkDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLL 271
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 33-255 3.83e-19

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 86.64  E-value: 3.83e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743  33 CWADRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVA-----CAKALLENGAHVNGLTVHGATPLF 107
Cdd:PHA03100  32 YKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLtdvkeIVKLLLEYGANVNAPDNNGITPLL 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743 108 NA--CCSGSAACVNVLLEFGAKAQL-EVYLASPIHEAVKRGHR--ECMEILLANNVNIEqeipqlgtplyvACTyqRVDC 182
Cdd:PHA03100 112 YAisKKSNSYSIVEYLLDNGANVNIkNSDGENLLHLYLESNKIdlKILKLLIDKGVDIN------------AKN--RVNY 177

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157819743 183 vkkLLELGASVD----HGrwlDTPLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELAAPKSSVE-QALLLHEGP 255
Cdd:PHA03100 178 ---LLSYGVPINikdvYG---FTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEiFKLLLNNGP 249
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 253-294 2.20e-16

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 71.36  E-value: 2.20e-16
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 157819743 253 EGPPALSQLCRLCVRKCLGRTCHQAIYALGLPEPLEKFLLYQ 294
Cdd:cd03728    1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
73-160 4.27e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.37  E-value: 4.27e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743   73 LHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNACCSGSAACVNVLLEFgAKAQLEVYLASPIHEAVKRGHRECMEI 152
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKL 79


                  ....*...
gi 157819743  153 LLANNVNI 160
Cdd:pfam12796  80 LLEKGADI 87
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 254-292 2.56e-09

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 51.78  E-value: 2.56e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 157819743  254 GPPALSQLCRLCVRKCLGRTCHQAIYALGLPEPLEKFLL 292
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 36-240 1.51e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 46.23  E-value: 1.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743   36 DRSPLHEAAAQGRLLALKTLiaqginvnLVTINRVSSLHEACLggHvacaKALLENGAHVNGLTVHgatPLFNACCSGSA 115
Cdd:TIGR00870  52 GRSALFVAAIENENLELTEL--------LLNLSCRGAVGDTLL--H----AISLEYVDAVEAILLH---LLAAFRKSGPL 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743  116 ACVNvllefgAKAQLEVYLA-SPIHEAVKRGHRECMEILLANNVNIEqeipqlgtplyVACTYqrVDCVKKllELGASVD 194
Cdd:TIGR00870 115 ELAN------DQYTSEFTPGiTALHLAAHRQNYEIVKLLLERGASVP-----------ARACG--DFFVKS--QGVDSFY 173

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 157819743  195 HGRwldTPLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELAA 240
Cdd:TIGR00870 174 HGE---SPLNAAACLGSPSIVALLSEDPADILTADSLGNTLLHLLV 216
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 104-236 3.16e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 45.00  E-value: 3.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743 104 TPLFNACCSGSAACVNVLLEF--------GAKAQlevylaSPIHEAVKRGHRECMEILLAN-----NVNIEQEIPQLGTP 170
Cdd:cd22192   19 SPLLLAAKENDVQAIKKLLKCpscdlfqrGALGE------TALHVAALYDNLEAAVVLMEAapelvNEPMTSDLYQGETA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743 171 LYVACTYQRVDCVKKLLELGASVDHGRWLDT---------------PLHAAARQSSVEVINLLTEYGANLKLRNSQGKSA 235
Cdd:cd22192   93 LHIAVVNQNLNLVRELIARGADVVSPRATGTffrpgpknliyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTV 172


                 .
gi 157819743 236 L 236
Cdd:cd22192  173 L 173
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 256-294 8.25e-05

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 38.93  E-value: 8.25e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 157819743   256 PALSQLCRLCVRKCLGrtchqAIYALGLPEPLEKFLLYQ 294
Cdd:smart00969   1 RSLQHLCRLAIRRSLG-----GIDKLPLPPRLKDYLLYY 34
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 169-194 7.48e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 33.33  E-value: 7.48e-03
                           10        20
                   ....*....|....*....|....*.
gi 157819743   169 TPLYVACTYQRVDCVKKLLELGASVD 194
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
35-251 4.20e-34

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 125.45  E-value: 4.20e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743  35 ADRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNACCSGS 114
Cdd:COG0666   53 LGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGN 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743 115 AACVNVLLEFGAKA-QLEVYLASPIHEAVKRGHRECMEILLANNVNIEQEIPQLGTPLYVACTYQRVDCVKKLLELGASV 193
Cdd:COG0666  133 LEIVKLLLEAGADVnAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADV 212

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 157819743 194 DH-GRWLDTPLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELAAPKSSVEQALLL 251
Cdd:COG0666  213 NAkDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLL 271
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
35-253 4.42e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 120.06  E-value: 4.42e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743  35 ADRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNACCSGS 114
Cdd:COG0666   20 LLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGD 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743 115 AACVNVLLEFGAK-AQLEVYLASPIHEAVKRGHRECMEILLANNVNIEQEIPQLGTPLYVACTYQRVDCVKKLLELGASV 193
Cdd:COG0666  100 LEIVKLLLEAGADvNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADV 179

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157819743 194 DH-GRWLDTPLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELAAPKSSVEQALLLHE 253
Cdd:COG0666  180 NArDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
36-191 1.34e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 103.11  E-value: 1.34e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743  36 DRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNACCSGSA 115
Cdd:COG0666  120 GETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHL 199

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157819743 116 ACVNVLLEFGAKAQLEV-YLASPIHEAVKRGHRECMEILLANNVNIEQEIPQLGTPLYVACTYQRVDCVKKLLELGA 191
Cdd:COG0666  200 EIVKLLLEAGADVNAKDnDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALL 276
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 33-255 3.83e-19

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 86.64  E-value: 3.83e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743  33 CWADRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVA-----CAKALLENGAHVNGLTVHGATPLF 107
Cdd:PHA03100  32 YKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLtdvkeIVKLLLEYGANVNAPDNNGITPLL 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743 108 NA--CCSGSAACVNVLLEFGAKAQL-EVYLASPIHEAVKRGHR--ECMEILLANNVNIEqeipqlgtplyvACTyqRVDC 182
Cdd:PHA03100 112 YAisKKSNSYSIVEYLLDNGANVNIkNSDGENLLHLYLESNKIdlKILKLLIDKGVDIN------------AKN--RVNY 177

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157819743 183 vkkLLELGASVD----HGrwlDTPLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELAAPKSSVE-QALLLHEGP 255
Cdd:PHA03100 178 ---LLSYGVPINikdvYG---FTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEiFKLLLNNGP 249
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
34-171 1.03e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 78.46  E-value: 1.03e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743  34 WADRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNACCSG 113
Cdd:COG0666  151 NDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENG 230

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 157819743 114 SAACVNVLLEFGAKAQLEV-YLASPIHEAVKRGHRECMEILLANNVNIEQEIPQLGTPL 171
Cdd:COG0666  231 NLEIVKLLLEAGADLNAKDkDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
SOCS_ASB_9_11 cd03728
SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have ...
 253-294 2.20e-16

SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239698  Cd Length: 42  Bit Score: 71.36  E-value: 2.20e-16
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 157819743 253 EGPPALSQLCRLCVRKCLGRTCHQAIYALGLPEPLEKFLLYQ 294
Cdd:cd03728    1 EGPPSLMQLCRLCIRKCFGRKQHHKIHKLHLPEPLKHFLLYR 42
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 52-239 1.90e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 76.16  E-value: 1.90e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743  52 LKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNACCSGSAACVNVLLEFGAKAQL- 130
Cdd:PHA02874 107 IKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVk 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743 131 EVYLASPIHEAVKRGHRECMEILLANNVNIEQEIPQLGTPLYVACTYQRvdCVKKLLELGASVD----HGRwldTPLHAA 206
Cdd:PHA02874 187 DNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNR--SAIELLINNASINdqdiDGS---TPLHHA 261

                        170       180       190
                 ....*....|....*....|....*....|....
gi 157819743 207 AR-QSSVEVINLLTEYGANLKLRNSQGKSALELA 239
Cdd:PHA02874 262 INpPCDIDIIDILLYHKADISIKDNKGENPIDTA 295
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 37-239 2.60e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 75.87  E-value: 2.60e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743  37 RSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLEN------------------------- 91
Cdd:PHA02876 179 ITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNrsninkndlsllkairnedletsll 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743  92 ----GAHVNGLTVHGATPLFNACCSGS-AACVNVLLEFGAKAQLE-VYLASPIHEAVKRGH-RECMEILLANNVNIEQEI 164
Cdd:PHA02876 259 lydaGFSVNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKnIKGETPLYLMAKNGYdTENIRTLIMLGADVNAAD 338

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157819743 165 PQLGTPLYVACTYQRV-DCVKKLLELGASVDHGRWLD-TPLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELA 239
Cdd:PHA02876 339 RLYITPLHQASTLDRNkDIVITLLELGANVNARDYCDkTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFA 415
Ank_2 pfam12796
Ankyrin repeats (3 copies);
73-160 4.27e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.37  E-value: 4.27e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743   73 LHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNACCSGSAACVNVLLEFgAKAQLEVYLASPIHEAVKRGHRECMEI 152
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKL 79


                  ....*...
gi 157819743  153 LLANNVNI 160
Cdd:pfam12796  80 LLEKGADI 87
Ank_2 pfam12796
Ankyrin repeats (3 copies);
138-229 1.31e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.83  E-value: 1.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743  138 IHEAVKRGHRECMEILLANNVNIEQEIPQLGTPLYVACTYQRVDCVKKLLElGASVDHGRWLDTPLHAAARQSSVEVINL 217
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|..
gi 157819743  218 LTEYGANLKLRN 229
Cdd:pfam12796  80 LLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
40-127 2.34e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.45  E-value: 2.34e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743   40 LHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENgAHVNgLTVHGATPLFNACCSGSAACVN 119
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVN-LKDNGRTALHYAARSGHLEIVK 78


                  ....*...
gi 157819743  120 VLLEFGAK 127
Cdd:pfam12796  79 LLLEKGAD 86
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 253-294 1.19e-13

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 64.05  E-value: 1.19e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 157819743 253 EGPPALSQLCRLCVRKCLGRTCHQAIYALGLPEPLEKFLLYQ 294
Cdd:cd03716    1 STPRSLQHLCRLAIRRCLGRRRLELIKKLPLPPRLKDYLLYE 42
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 86-244 5.50e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 68.75  E-value: 5.50e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743  86 KALLENGAHVNGLTVH-GATPLFNACCSGSAACVNVLLEFGAKAQ-LEVYLASPIHEAVKRGHRECMEILLANNVNIEQE 163
Cdd:PHA02878 151 KLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNiPDKTNNSPLHHAVKHYNKPIVHILLENGASTDAR 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743 164 IPQLGTPLYVACTY-QRVDCVKKLLELGASVDHGRWLD--TPLHAAARqsSVEVINLLTEYGANLKLRNSQGKSALELAA 240
Cdd:PHA02878 231 DKCGNTPLHISVGYcKDYDILKLLLEHGVDVNAKSYILglTALHSSIK--SERKLKLLLEYGADINSLNSYKLTPLSSAV 308


                 ....
gi 157819743 241 PKSS 244
Cdd:PHA02878 309 KQYL 312
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 38-254 7.28e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 68.55  E-value: 7.28e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743  38 SPLHEAAAQGRLLAL-KTLIAQGINVNLVTINRVSSLHEACLGGH-VACAKALLENGAHVNGLTVHGATPLFNACC-SGS 114
Cdd:PHA02876 275 TPLHHASQAPSLSRLvPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHQASTlDRN 354

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743 115 AACVNVLLEFGAKAQLEVYL-ASPIHEAVKRGHRECMEILLANNVNIEQEIPQLGTPLYVA-CTYQRVDCVKKLLELGAS 192
Cdd:PHA02876 355 KDIVITLLELGANVNARDYCdKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFAlCGTNPYMSVKTLIDRGAN 434

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157819743 193 VD-HGRWLDTPLHAAARQS-SVEVINLLTEYGANLKLRNSQGKSALELAAPKSSVEQaLLLHEG 254
Cdd:PHA02876 435 VNsKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIALEYHGIVN-ILLHYG 497
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 72-246 3.41e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 63.09  E-value: 3.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743  72 SLHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVY-LASPIHEAVKRGHRECM 150
Cdd:PHA02875   5 ALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPdIESELHDAVEEGDVKAV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743 151 EILLANNVNIEQEIPQLG-TPLYVACTYQRVDCVKKLLELGASVDHGRwLD--TPLHAAARQSSVEVINLLTEYGANLKL 227
Cdd:PHA02875  85 EELLDLGKFADDVFYKDGmTPLHLATILKKLDIMKLLIARGADPDIPN-TDkfSPLHLAVMMGDIKGIELLIDHKACLDI 163

                        170
                 ....*....|....*....
gi 157819743 228 RNSQGKSALELAAPKSSVE 246
Cdd:PHA02875 164 EDCCGCTPLIIAMAKGDIA 182
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 255-294 3.68e-11

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 57.09  E-value: 3.68e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 157819743 255 PPALSQLCRLCVRKCLGRTCHQAIYALGLPEPLEKFLLYQ 294
Cdd:cd03587    2 PRSLQHLCRLAIRRCLGKRRLDLIDKLPLPPRLKDYLLYK 41
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 47-240 2.75e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 60.36  E-value: 2.75e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743  47 GRLLALKTLIAQGIN-VNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNACCSGSAACVNVLLEFG 125
Cdd:PHA02874  12 GDIEAIEKIIKNKGNcINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743 126 AKAQLevyLASPIHEavkrghRECMEILLANNVNIEQEIPQLGTPLYVACTYQRVDCVKKLLELGASV----DHGRWldt 201
Cdd:PHA02874  92 VDTSI---LPIPCIE------KDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVniedDNGCY--- 159

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 157819743 202 PLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELAA 240
Cdd:PHA02874 160 PIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAA 198
PHA03095 PHA03095
ankyrin-like protein; Provisional
 36-240 1.25e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 58.50  E-value: 1.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743  36 DRSPLH---EAAAQGRLLALKTLIAQGINVNLVTINRVSSLH-EACLGGHVACAKALLENGAHVNGLTVHGATPLfNACC 111
Cdd:PHA03095  47 GKTPLHlylHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHlYLYNATTLDVIKLLIKAGADVNAKDKVGRTPL-HVYL 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743 112 SG---SAACVNVLLEFGAKAQ-LEVYLASPIHEAVKRgHRECMEIL---------LANNVNIEQeipqlgTPLYVACTY- 177
Cdd:PHA03095 126 SGfniNPKVIRLLLRKGADVNaLDLYGMTPLAVLLKS-RNANVELLrllidagadVYAVDDRFR------SLLHHHLQSf 198

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157819743 178 -QRVDCVKKLLELGASVDHGRWLD-TPLHAAARQSSVEVINL--LTEYGANLKLRNSQGKSALELAA 240
Cdd:PHA03095 199 kPRARIVRELIRAGCDPAATDMLGnTPLHSMATGSSCKRSLVlpLLIAGISINARNRYGQTPLHYAA 265
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 254-292 2.56e-09

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 51.78  E-value: 2.56e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 157819743  254 GPPALSQLCRLCVRKCLGRTCHQAIYALGLPEPLEKFLL 292
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 104-253 5.37e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 56.51  E-value: 5.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743 104 TPLFNACCSGSAACVNVLLEFGAKA-QLEVYLASPIHEAVKRGHRECMEILLANNVNIeqeipqlgTPLYVACTYQrvDC 182
Cdd:PHA02874  37 TPLIDAIRSGDAKIVELFIKHGADInHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDT--------SILPIPCIEK--DM 106

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157819743 183 VKKLLELGASVD-HGRWLDTPLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELAAPKSSVEQALLLHE 253
Cdd:PHA02874 107 IKTILDCGIDVNiKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLE 178
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 38-167 1.15e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 55.44  E-value: 1.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743  38 SPLHEAAAQ--GRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHV--ACAKALLENGAHVNGLT-------------- 99
Cdd:PHA03100 108 TPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIdlKILKLLIDKGVDINAKNrvnyllsygvpini 187

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157819743 100 --VHGATPLFNACCSGSAACVNVLLEFGAKAQL-EVYLASPIHEAVKRGHRECMEILLANNVNIEQEIPQL 167
Cdd:PHA03100 188 kdVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLvNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIETL 258
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 38-224 1.29e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 55.38  E-value: 1.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743  38 SPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGLTVH-GATPLFNACCSGSAA 116
Cdd:PHA02875  37 SPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYKdGMTPLHLATILKKLD 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743 117 CVNVLLEFGAKAQL-EVYLASPIHEAVKRGHRECMEILLANNVNIEQEIPQLGTPLYVACTYQRVDCVKKLLELGASVDH 195
Cdd:PHA02875 117 IMKLLIARGADPDIpNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDY 196

                        170       180       190
                 ....*....|....*....|....*....|.
gi 157819743 196 -GRWLD-TPLHAAARQSSVEVINLLTEYGAN 224
Cdd:PHA02875 197 fGKNGCvAALCYAIENNKIDIVRLFIKRGAD 227
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 43-195 1.42e-08

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 55.64  E-value: 1.42e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743  43 AAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNACCSGSAACVNVLL 122
Cdd:PLN03192 532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILY 611

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743 123 EFGAkaqlevylASPIH-------EAVKRGHRECMEILLANNVNIEQEIPQLGTPLYVACTYQRVDCVKKLLELGASVDH 195
Cdd:PLN03192 612 HFAS--------ISDPHaagdllcTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDK 683
PHA03095 PHA03095
ankyrin-like protein; Provisional
 42-237 1.92e-08

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 55.03  E-value: 1.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743  42 EAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAK---ALLENGAHVNGLTVHGATPLFnaCCSGSAACV 118
Cdd:PHA03095  20 LNASNVTVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDivrLLLEAGADVNAPERCGFTPLH--LYLYNATTL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743 119 NVllefgakaqlevylaspiheavkrghrecMEILLANNVNIEQEIPQLGTPLYVACTYQRVD--CVKKLLELGASV--- 193
Cdd:PHA03095  98 DV-----------------------------IKLLIKAGADVNAKDKVGRTPLHVYLSGFNINpkVIRLLLRKGADVnal 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 157819743 194 -DHGRwldTPLHAAARQS--SVEVINLLTEYGANLKLRNSQGKSALE 237
Cdd:PHA03095 149 dLYGM---TPLAVLLKSRnaNVELLRLLIDAGADVYAVDDRFRSLLH 192
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 38-204 3.00e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 54.68  E-value: 3.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743  38 SPLHEAAAQGRLL-ALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGLTVHGATPL-FNACCSGSA 115
Cdd:PHA02876 343 TPLHQASTLDRNKdIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALhFALCGTNPY 422

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743 116 ACVNVLLEFGAKAQLE-VYLASPIHEAVKRGHR-ECMEILLANNVNIEQEIPQLGTPLYVACTYQRVdcVKKLLELGASV 193
Cdd:PHA02876 423 MSVKTLIDRGANVNSKnKDLSTPLHYACKKNCKlDVIEMLLDNGADVNAINIQNQYPLLIALEYHGI--VNILLHYGAEL 500

                        170
                 ....*....|.
gi 157819743 194 DHGRWLDTPLH 204
Cdd:PHA02876 501 RDSRVLHKSLN 511
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 106-251 4.23e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 53.84  E-value: 4.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743 106 LFNACCSGSAACVNVLLEFGAKAQLEVYLA-SPIHEAVKRGHRECMEILLANNVNIEQEIPQLGTPLYVACTYQRVDCVK 184
Cdd:PHA02875   6 LCDAILFGELDIARRLLDIGINPNFEIYDGiSPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVE 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157819743 185 KLLELGASVDHGRWLD--TPLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELAAPKSSVEQALLL 251
Cdd:PHA02875  86 ELLDLGKFADDVFYKDgmTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELL 154
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 36-187 1.95e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 51.80  E-value: 1.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743  36 DRSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNAccsgSA 115
Cdd:PHA02878 168 GNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHIS----VG 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743 116 ACVN-----VLLEFGAKAQLEVYLA--SPIHEAVKRGHRecMEILL-----ANNVNIEQEipqlgTPLYVAC-TYQRVDC 182
Cdd:PHA02878 244 YCKDydilkLLLEHGVDVNAKSYILglTALHSSIKSERK--LKLLLeygadINSLNSYKL-----TPLSSAVkQYLCINI 316


                 ....*
gi 157819743 183 VKKLL 187
Cdd:PHA02878 317 GRILI 321
Ank_4 pfam13637
Ankyrin repeats (many copies);
37-89 2.82e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.50  E-value: 2.82e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 157819743   37 RSPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALL 89
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 55-240 4.50e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 50.83  E-value: 4.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743  55 LIAQGINVNLVTINRVS-------SLHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNACCSGSAACVNVLLEFGAK 127
Cdd:PHA02876 124 ILKEAISGNDIHYDKINesieymkLIKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGAD 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743 128 AQLEVYLASPIHE-AVKRGHRECMEILLANNVNIEQEipqlGTPLYVACTYQRVDCVKKLLELGASVDH-GRWLDTPLHA 205
Cdd:PHA02876 204 VNIIALDDLSVLEcAVDSKNIDTIKAIIDNRSNINKN----DLSLLKAIRNEDLETSLLLYDAGFSVNSiDDCKNTPLHH 279

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 157819743 206 AARQSSV-EVINLLTEYGANLKLRNSQGKSALELAA 240
Cdd:PHA02876 280 ASQAPSLsRLVPKLLERGADVNAKNIKGETPLYLMA 315
Ank_2 pfam12796
Ankyrin repeats (3 copies);
37-96 1.27e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 45.88  E-value: 1.27e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743   37 RSPLHEAAAQGRLLALKTLIAQgINVNLVTINRvSSLHEACLGGHVACAKALLENGAHVN 96
Cdd:pfam12796  31 RTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGR-TALHYAARSGHLEIVKLLLEKGADIN 88
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 85-154 1.51e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.51  E-value: 1.51e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157819743  85 AKALLENGAHVNGLTVHGATPLFNACCSGSAACVNVLLEFGAKAQ-LEVYLASPIHEAVKRGHRECMEILL 154
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTlLDKDGKTPLELAEENGFREVVQLLS 168
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 39-185 2.54e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 48.42  E-value: 2.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743  39 PLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNACCSGSAAcV 118
Cdd:PHA02874 160 PIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSA-I 238

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157819743 119 NVLLEFGAKAQLEVYLASPIHEAVKRG-HRECMEILLANNVNIEQEIPQLGTPLYVACTYQRVDCVKK 185
Cdd:PHA02874 239 ELLINNASINDQDIDGSTPLHHAINPPcDIDIIDILLYHKADISIKDNKGENPIDTAFKYINKDPVIK 306
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 255-294 2.75e-06

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 43.44  E-value: 2.75e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 157819743 255 PPALSQLCRLCVRKCLGRTCHQAIYALGLPEPLEKFLLYQ 294
Cdd:cd03718    3 PLPLMDLCRRRVRVALGRDRLEEIEQLPLPPSLKNYLLYQ 42
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 73-254 4.08e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 47.95  E-value: 4.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743  73 LHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNAC-----------------CSGS--------------------- 114
Cdd:PHA02878  41 LHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICkepnklgmkemirsinkCSVFytlvaikdafnnrnveifkii 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743 115 --------------------------AACVNVLLEFGAKAQL--EVYLASPIHEAVKRGHRECMEILLANNVNIeqEIPQ 166
Cdd:PHA02878 121 ltnrykniqtidlvyidkkskddiieAEITKLLLSYGADINMkdRHKGNTALHYATENKDQRLTELLLSYGANV--NIPD 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743 167 LG--TPLYVACTYQRVDCVKKLLELGASVDH-GRWLDTPLH-AAARQSSVEVINLLTEYGANLKLRNS-QGKSALELAAp 241
Cdd:PHA02878 199 KTnnSPLHHAVKHYNKPIVHILLENGASTDArDKCGNTPLHiSVGYCKDYDILKLLLEHGVDVNAKSYiLGLTALHSSI- 277

                        250
                 ....*....|...
gi 157819743 242 KSSVEQALLLHEG 254
Cdd:PHA02878 278 KSERKLKLLLEYG 290
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
 255-294 7.74e-06

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 42.17  E-value: 7.74e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 157819743 255 PPALSQLCRLCVRKCLGRTCHQAIYALGLPEPLEKFLLYQ 294
Cdd:cd03724    3 PSSLCQLCRLCIRNYIGRSRLHLIPQLQLPTLLKNFLQYR 42
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 37-191 1.23e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 46.14  E-value: 1.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743  37 RSPLHEAAAQGRLLALKTLIAQGINVNLVTINR-VSSLHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNACCSGSA 115
Cdd:PHA02875  69 ESELHDAVEEGDVKAVEELLDLGKFADDVFYKDgMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDI 148

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157819743 116 ACVNVLLEFGAKAQLE-VYLASPIHEAVKRGHRECMEILLANNVNIE--QEIPQLgTPLYVACTYQRVDCVKKLLELGA 191
Cdd:PHA02875 149 KGIELLIDHKACLDIEdCCGCTPLIIAMAKGDIAICKMLLDSGANIDyfGKNGCV-AALCYAIENNKIDIVRLFIKRGA 226
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 36-240 1.51e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 46.23  E-value: 1.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743   36 DRSPLHEAAAQGRLLALKTLiaqginvnLVTINRVSSLHEACLggHvacaKALLENGAHVNGLTVHgatPLFNACCSGSA 115
Cdd:TIGR00870  52 GRSALFVAAIENENLELTEL--------LLNLSCRGAVGDTLL--H----AISLEYVDAVEAILLH---LLAAFRKSGPL 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743  116 ACVNvllefgAKAQLEVYLA-SPIHEAVKRGHRECMEILLANNVNIEqeipqlgtplyVACTYqrVDCVKKllELGASVD 194
Cdd:TIGR00870 115 ELAN------DQYTSEFTPGiTALHLAAHRQNYEIVKLLLERGASVP-----------ARACG--DFFVKS--QGVDSFY 173

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 157819743  195 HGRwldTPLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELAA 240
Cdd:TIGR00870 174 HGE---SPLNAAACLGSPSIVALLSEDPADILTADSLGNTLLHLLV 216
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 40-128 3.16e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 45.27  E-value: 3.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743  40 LHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNACCSGSAACVN 119
Cdd:PTZ00322  86 LCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165

                         90
                 ....*....|....*.
gi 157819743 120 VLL-------EFGAKA 128
Cdd:PTZ00322 166 LLSrhsqchfELGANA 181
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 104-236 3.16e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 45.00  E-value: 3.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743 104 TPLFNACCSGSAACVNVLLEF--------GAKAQlevylaSPIHEAVKRGHRECMEILLAN-----NVNIEQEIPQLGTP 170
Cdd:cd22192   19 SPLLLAAKENDVQAIKKLLKCpscdlfqrGALGE------TALHVAALYDNLEAAVVLMEAapelvNEPMTSDLYQGETA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743 171 LYVACTYQRVDCVKKLLELGASVDHGRWLDT---------------PLHAAARQSSVEVINLLTEYGANLKLRNSQGKSA 235
Cdd:cd22192   93 LHIAVVNQNLNLVRELIARGADVVSPRATGTffrpgpknliyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTV 172


                 .
gi 157819743 236 L 236
Cdd:cd22192  173 L 173
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 39-239 4.14e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 44.87  E-value: 4.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743  39 PLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLGGHVACAKALLengahvnglTVHGATPLFNACCSGSAACV 118
Cdd:PHA02878  40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMI---------RSINKCSVFYTLVAIKDAFN 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743 119 N--------VLLEFGAKAQL--EVYLASPIHEAVKRGhrECMEILLAN--NVNIEQEiPQLGTPLYVACTYQRVDCVKKL 186
Cdd:PHA02878 111 NrnveifkiILTNRYKNIQTidLVYIDKKSKDDIIEA--EITKLLLSYgaDINMKDR-HKGNTALHYATENKDQRLTELL 187

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 157819743 187 LELGASVDH-GRWLDTPLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELA 239
Cdd:PHA02878 188 LSYGANVNIpDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHIS 241
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 255-292 5.51e-05

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 40.12  E-value: 5.51e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 157819743 255 PPALSQLCRLCVRKCLGRTCHQAIYALGLPEPLEKFLL 292
Cdd:cd03723    3 PRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYLL 40
Ank_4 pfam13637
Ankyrin repeats (many copies);
69-122 5.88e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.95  E-value: 5.88e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 157819743   69 RVSSLHEACLGGHVACAKALLENGAHVNGLTVHGATPLFNACCSGSAACVNVLL 122
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 91-251 6.68e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 44.47  E-value: 6.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743  91 NGAHVNgltVHGATPLFNACCSGSAACVNVLLEFGAKAQL-EVYLASPIHEAVKRGHRECMEILLANNVNIEQEIPQLGT 169
Cdd:PLN03192 517 GGEHDD---PNMASNLLTVASTGNAALLEELLKAKLDPDIgDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNT 593

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743 170 PLYVACTYQRVDCVKKLLELGASVDHGRWLDTpLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELAAPKSSVEQAL 249
Cdd:PLN03192 594 ALWNAISAKHHKIFRILYHFASISDPHAAGDL-LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVR 672


                 ..
gi 157819743 250 LL 251
Cdd:PLN03192 673 LL 674
Ank_4 pfam13637
Ankyrin repeats (many copies);
169-218 6.88e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.95  E-value: 6.88e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 157819743  169 TPLYVACTYQRVDCVKKLLELGASVDH-GRWLDTPLHAAARQSSVEVINLL 218
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAvDGNGETALHFAASNGNVEVLKLL 53
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 256-294 8.25e-05

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 38.93  E-value: 8.25e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 157819743   256 PALSQLCRLCVRKCLGrtchqAIYALGLPEPLEKFLLYQ 294
Cdd:smart00969   1 RSLQHLCRLAIRRSLG-----GIDKLPLPPRLKDYLLYY 34
SOCS_SSB2 cd03719
SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins) ...
 253-294 1.24e-04

SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB2, like SSB4 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239689  Cd Length: 42  Bit Score: 38.85  E-value: 1.24e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 157819743 253 EGPPALSQLCRLCVRKCLGRTCHQAIYALGLPEPLEKFLLYQ 294
Cdd:cd03719    1 AEPHSLLHLSRLCVRHALGDTRLGQVSALPLPPAMKRYLLYQ 42
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 255-294 1.27e-04

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 38.94  E-value: 1.27e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 157819743 255 PPALSQLCRLCVRKCLGRTCHQAIYALGLPEPLEKFLLYQ 294
Cdd:cd03720    3 PRSLLSLCRIAVRRALGKQRLSLICSLPLPDPIKKFLLHE 42
Ank_5 pfam13857
Ankyrin repeats (many copies);
197-239 2.09e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.48  E-value: 2.09e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 157819743  197 RWLDTPLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELA 239
Cdd:pfam13857  14 GEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 183-252 2.50e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.58  E-value: 2.50e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157819743 183 VKKLLELGASVD----HGRwldTPLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELAAPKS--SVEQALLLH 252
Cdd:PTZ00322  98 ARILLTGGADPNcrdyDGR---TPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGfrEVVQLLSRH 170
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
 255-293 3.08e-04

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 37.84  E-value: 3.08e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 157819743 255 PPALSQLCRLCVRKCLGRTCHQAIYALGLPEPLEKFLLY 293
Cdd:cd03729    3 PLSLQQLCRINLRKALGTRALEKIAKLNIPNRIIDYLSY 41
SOCS_SSB4 cd03743
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box ...
 255-294 4.02e-04

SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB4, like SSB2 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239712  Cd Length: 42  Bit Score: 37.24  E-value: 4.02e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 157819743 255 PPALSQLCRLCVRKCLGRTCHQAIYALGLPEPLEKFLLYQ 294
Cdd:cd03743    3 PLPLMDLCRRSARQALGRHRLHHIQSLPLPQTLKNYLQYQ 42
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 253-294 4.31e-04

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 37.54  E-value: 4.31e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 157819743 253 EGPPALSQLCRLCVRKCLGRTCHQAIYALGLPEPLEKFLLYQ 294
Cdd:cd03721    1 EPPRPLAHLCRLKVRTLIGINRIKLIDTLPLPPRLIRYLNHQ 42
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 169-244 5.26e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.42  E-value: 5.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819743 169 TPLYVACTYQRVDCVKKLLELGASVDhgrWLD----TPLHAAARQSSVEVINLLTEY-------GANLKLRNSQGKSALE 237
Cdd:PTZ00322 117 TPLHIACANGHVQVVRVLLEFGADPT---LLDkdgkTPLELAEENGFREVVQLLSRHsqchfelGANAKPDSFTGKPPSL 193


                 ....*..
gi 157819743 238 LAAPKSS 244
Cdd:PTZ00322 194 EDSPISS 200
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 38-109 6.45e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 41.10  E-value: 6.45e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157819743  38 SPLHEAAAQGRLLALKTLIAQGINVNLVTINRVSSLHEACLggHVACAKALLENGAHVNGLTVHGATPLFNA 109
Cdd:PHA02874 192 SPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII--HNRSAIELLINNASINDQDIDGSTPLHHA 261
SOCS_SSB1 cd03744
SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins) ...
 255-294 8.95e-04

SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), both the absence and the presence of HGF and enhances the HGF-MET-induced mitogen-activated protein kinases Erk-transcription factor Elk-1-serum response elements (SRE) pathway. SSB1, like SSB2 and SSB4, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239713  Cd Length: 42  Bit Score: 36.50  E-value: 8.95e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 157819743 255 PPALSQLCRLCVRKCLGRTCHQAIYALGLPEPLEKFLLYQ 294
Cdd:cd03744    3 PLPLMDLCRRSVRLALGRERLSEIHTLPLPASLKNYLLYQ 42
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 253-294 1.14e-03

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 36.36  E-value: 1.14e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 157819743 253 EGPPALSQLCRLCVRKCLGR---TCHQAIYALGLPEPLEKFLLYQ 294
Cdd:cd03730    1 TNPRSLKHLCRLKIRACMGRlrlRCPVFMSFLPLPNRLKAYILYK 45
Ank_5 pfam13857
Ankyrin repeats (many copies);
55-106 1.80e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.79  E-value: 1.80e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 157819743   55 LIAQG-INVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGLTVHGATPL 106
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
Ank_4 pfam13637
Ankyrin repeats (many copies);
201-252 3.87e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 34.94  E-value: 3.87e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 157819743  201 TPLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELAAPKSSVEQALLLH 252
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 169-194 7.48e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 33.33  E-value: 7.48e-03
                           10        20
                   ....*....|....*....|....*.
gi 157819743   169 TPLYVACTYQRVDCVKKLLELGASVD 194
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADIN 29
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 186-246 9.24e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 37.35  E-value: 9.24e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157819743 186 LLELGASVDHGR-WLDTPLHAAARQSSVEVINLLTEYGANLKLRNSQGKSALELAAPKSSVE 246
Cdd:PHA02876 164 LLEGGADVNAKDiYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNID 225
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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