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Conserved domains on  [gi|157412328|ref|NP_001098707|]
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coronin-1C isoform a [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 61-455 3.45e-110

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 336.87  E-value: 3.45e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328  61 SKFRHVFGQAVKNDQCYDDIRVSRVTWD-SSFCAVNPRFVAIIIEASGGGAflVLPLHKTGRIDKSYPTVCGHTGPVLDI 139
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328 140 DWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLTEPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEAl 219
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKA- 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328 220 INLDDMHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEkAHEGARPMRAIFLADGN-VFTTGFSRMSERQL 298
Cdd:PTZ00421 161 VEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQRQI 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328 299 ALWNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESPYVHYlnTFSSKEPQRGMGYMPKRGL 378
Cdd:PTZ00421 240 MLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSL 317

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157412328 379 DVNKCEIARFFKLHERKCEPIIMTVPRK-SDL-FQDDLYPDTAGPEAALEAEEWFEGKNADPILISLkHGYIPGKNRDL 455
Cdd:PTZ00421 318 DTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDM-SAVFDGTSPEL 395
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 61-455 3.45e-110

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 336.87  E-value: 3.45e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328  61 SKFRHVFGQAVKNDQCYDDIRVSRVTWD-SSFCAVNPRFVAIIIEASGGGAflVLPLHKTGRIDKSYPTVCGHTGPVLDI 139
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328 140 DWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLTEPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEAl 219
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKA- 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328 220 INLDDMHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEkAHEGARPMRAIFLADGN-VFTTGFSRMSERQL 298
Cdd:PTZ00421 161 VEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQRQI 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328 299 ALWNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESPYVHYlnTFSSKEPQRGMGYMPKRGL 378
Cdd:PTZ00421 240 MLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSL 317

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157412328 379 DVNKCEIARFFKLHERKCEPIIMTVPRK-SDL-FQDDLYPDTAGPEAALEAEEWFEGKNADPILISLkHGYIPGKNRDL 455
Cdd:PTZ00421 318 DTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDM-SAVFDGTSPEL 395
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 56-121 4.22e-36

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 128.39  E-value: 4.22e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157412328   56 RVVRQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSSFCAVNPRFVAIIIEASGGGAFLVLPLHKTGR 121
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 128-353 6.49e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.20  E-value: 6.49e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328 128 TVCGHTGPVLDIDWCPHNDQvIASGSEDCTVMVWQipengltLSLTEPVVILEGHSKRVGIVAWHPTARnVLLSAGCDNA 207
Cdd:cd00200   46 TLKGHTGPVRDVAASADGTY-LASGSSDKTIRLWD-------LETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKT 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328 208 IIIWNVGTGEALINLDDmHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEkAHEGarPMRAI-FLADGNVF 286
Cdd:cd00200  117 IKVWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLT-GHTG--EVNSVaFSPDGEKL 192

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328 287 TTGFsrmSERQLALWNPKnMQEPIAL---HEmDTSNGVLlpfYDPDTSIIyLCGKGDSSIRYFEITDESP 353
Cdd:cd00200  193 LSSS---SDGTIKLWDLS-TGKCLGTlrgHE-NGVNSVA---FSPDGYLL-ASGSEDGTIRVWDLRTGEC 253
WD40 COG2319
WD40 repeat [General function prediction only];
131-305 2.67e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 2.67e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328 131 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVWQIPENgltlsltEPVVILEGHSKRVGIVAWHPTARnVLLSAGCDNAIII 210
Cdd:COG2319  160 GHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATG-------KLLRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVRL 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328 211 WNVGTGEALINLDDmHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEkaHEGARPMRAIFLADGNVFTTGf 290
Cdd:COG2319  231 WDLATGKLLRTLTG-HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT--GHSGGVNSVAFSPDGKLLASG- 306

                        170
                 ....*....|....*
gi 157412328 291 srMSERQLALWNPKN 305
Cdd:COG2319  307 --SDDGTVRLWDLAT 319
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 131-161 1.29e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.29e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 157412328   131 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVW 161
Cdd:smart00320  10 GHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 61-455 3.45e-110

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 336.87  E-value: 3.45e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328  61 SKFRHVFGQAVKNDQCYDDIRVSRVTWD-SSFCAVNPRFVAIIIEASGGGAflVLPLHKTGRIDKSYPTVCGHTGPVLDI 139
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328 140 DWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLTEPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEAl 219
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKA- 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328 220 INLDDMHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEkAHEGARPMRAIFLADGN-VFTTGFSRMSERQL 298
Cdd:PTZ00421 161 VEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQRQI 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328 299 ALWNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESPYVHYlnTFSSKEPQRGMGYMPKRGL 378
Cdd:PTZ00421 240 MLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSL 317

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157412328 379 DVNKCEIARFFKLHERKCEPIIMTVPRK-SDL-FQDDLYPDTAGPEAALEAEEWFEGKNADPILISLkHGYIPGKNRDL 455
Cdd:PTZ00421 318 DTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDM-SAVFDGTSPEL 395
PTZ00420 PTZ00420
coronin; Provisional
 77-508 3.69e-66

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 224.06  E-value: 3.69e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328  77 YDDIRV-SRVTwDSSFCAVNPRFVAIIIEASGGGAFLVLPLHKTGRidksYPTVC---GHTGPVLDIDWCPHNDQVIASG 152
Cdd:PTZ00420  19 FDDLRIcSRVI-DSCGIACSSGFVAVPWEVEGGGLIGAIRLENQMR----KPPVIklkGHTSSILDLQFNPCFSEILASG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328 153 SEDCTVMVWQIPENGLTLS-LTEPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEAL--INLDDMHSDM 229
Cdd:PTZ00420  94 SEDLTIRVWEIPHNDESVKeIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAfqINMPKKLSSL 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328 230 iynvSWNRNGSLICTASKDKKVRVIDPRKQEIvAEKEKAHEGARPMRAIFL-----ADGNVFTTGFSRMSERQLALWNPK 304
Cdd:PTZ00420 174 ----KWNIKGNLLSGTCVGKHMHIIDPRKQEI-ASSFHIHDGGKNTKNIWIdglggDDNYILSTGFSKNNMREMKLWDLK 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328 305 NMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESpyVHYLNTFSSKEPQRGMGYMPKRGLDVNKCE 384
Cdd:PTZ00420 249 NTTSALVTMSIDNASAPLIPHYDESTGLIYLIGKGDGNCRYYQHSLGS--IRKVNEYKSCSPFRSFGFLPKQICDVYKCE 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328 385 IARFFK-LHERKCEPIIMTVPRK-SDLFQDDLYPDTAGPEAALEAEEWFEGKNADPILISLKHgyipGKNRDLKVVKK-- 460
Cdd:PTZ00420 327 IGRVYKnENNSSIRPISFYVPRKnPTKFQEDLYPPILMHDPERSSRNWIDGKDNKMKRINIKD----LTEDDLRITKKyk 402

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 157412328 461 -------NILDSKPTANKKCdliSIPKKTTDTASVQNEAKLDEILKEIKSIKDTI 508
Cdd:PTZ00420 403 fvpqsfnSIIIGENYTSKRT---SIIRQFTKKFTFFKKGEHNDGFSSVDSFKESV 454
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 56-121 4.22e-36

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 128.39  E-value: 4.22e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157412328   56 RVVRQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSSFCAVNPRFVAIIIEASGGGAFLVLPLHKTGR 121
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 128-353 6.49e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.20  E-value: 6.49e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328 128 TVCGHTGPVLDIDWCPHNDQvIASGSEDCTVMVWQipengltLSLTEPVVILEGHSKRVGIVAWHPTARnVLLSAGCDNA 207
Cdd:cd00200   46 TLKGHTGPVRDVAASADGTY-LASGSSDKTIRLWD-------LETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKT 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328 208 IIIWNVGTGEALINLDDmHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEkAHEGarPMRAI-FLADGNVF 286
Cdd:cd00200  117 IKVWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLT-GHTG--EVNSVaFSPDGEKL 192

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328 287 TTGFsrmSERQLALWNPKnMQEPIAL---HEmDTSNGVLlpfYDPDTSIIyLCGKGDSSIRYFEITDESP 353
Cdd:cd00200  193 LSSS---SDGTIKLWDLS-TGKCLGTlrgHE-NGVNSVA---FSPDGYLL-ASGSEDGTIRVWDLRTGEC 253
WD40 COG2319
WD40 repeat [General function prediction only];
131-305 2.67e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 2.67e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328 131 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVWQIPENgltlsltEPVVILEGHSKRVGIVAWHPTARnVLLSAGCDNAIII 210
Cdd:COG2319  160 GHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATG-------KLLRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVRL 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328 211 WNVGTGEALINLDDmHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEkaHEGARPMRAIFLADGNVFTTGf 290
Cdd:COG2319  231 WDLATGKLLRTLTG-HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT--GHSGGVNSVAFSPDGKLLASG- 306

                        170
                 ....*....|....*
gi 157412328 291 srMSERQLALWNPKN 305
Cdd:COG2319  307 --SDDGTVRLWDLAT 319
WD40 COG2319
WD40 repeat [General function prediction only];
131-304 2.04e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.30  E-value: 2.04e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328 131 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVWQIpENGltlsltEPVVILEGHSKRVGIVAWHPTARnVLLSAGCDNAIII 210
Cdd:COG2319  118 GHTGAVRSVAFSP-DGKTLASGSADGTVRLWDL-ATG------KLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRL 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328 211 WNVGTGEALINLDDmHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEkaHEGARPMRAIFLADGNVFTTGf 290
Cdd:COG2319  189 WDLATGKLLRTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT--GHSGSVRSVAFSPDGRLLASG- 264

                        170
                 ....*....|....
gi 157412328 291 srMSERQLALWNPK 304
Cdd:COG2319  265 --SADGTVRLWDLA 276
WD40 COG2319
WD40 repeat [General function prediction only];
131-305 9.88e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 100.37  E-value: 9.88e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328 131 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVWQIPENgltlsltEPVVILEGHSKRVGIVAWHPTARnVLLSAGCDNAIII 210
Cdd:COG2319  244 GHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATG-------ELLRTLTGHSGGVNSVAFSPDGK-LLASGSDDGTVRL 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328 211 WNVGTGEALINLDDmHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKeKAHEGArPMRAIFLADGNVFTTGf 290
Cdd:COG2319  315 WDLATGKLLRTLTG-HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL-TGHTGA-VTSVAFSPDGRTLASG- 390

                        170
                 ....*....|....*
gi 157412328 291 SRmsERQLALWNPKN 305
Cdd:COG2319  391 SA--DGTVRLWDLAT 403
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 396-438 3.13e-21

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 86.41  E-value: 3.13e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 157412328  396 CEPIIMTVPRKS-DLFQDDLYPDTAGPEAALEAEEWFEGKNADP 438
Cdd:pfam16300   1 IEPISFTVPRKSkEDFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 131-289 1.04e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.40  E-value: 1.04e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328 131 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVWQIPENgltlsltEPVVILEGHSKRVGIVAWHPTARNvLLSAGCDNAIII 210
Cdd:cd00200  133 GHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTG-------KCVATLTGHTGEVNSVAFSPDGEK-LLSSSSDGTIKL 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328 211 WNVGTGEALINLDDmHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKeKAHEGarPMRAI-FLADGNVFTTG 289
Cdd:cd00200  204 WDLSTGKCLGTLRG-HENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL-SGHTN--SVTSLaWSPDGKRLASG 279
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 131-253 1.30e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.15  E-value: 1.30e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328 131 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVWQipengltLSLTEPVVILEGHSKRVGIVAWHPTaRNVLLSAGCDNAIII 210
Cdd:cd00200  175 GHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWD-------LSTGKCLGTLRGHENGVNSVAFSPD-GYLLASGSEDGTIRV 245

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 157412328 211 WNVGTGEALINLDdMHSDMIYNVSWNRNGSLICTASKDKKVRV 253
Cdd:cd00200  246 WDLRTGECVQTLS-GHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 179-353 1.52e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.13  E-value: 1.52e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328 179 LEGHSKRVGIVAWHPTaRNVLLSAGCDNAIIIWNVGTGEALINLDDmHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRK 258
Cdd:cd00200    5 LKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLKG-HTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328 259 QEIVAEKEkAHEGarPMRAI-FLADGNVFTTGfsrMSERQLALWNPKNMQEPIAL--HEMDTSNGVllpfYDPDTSIIYl 335
Cdd:cd00200   83 GECVRTLT-GHTS--YVSSVaFSPDGRILSSS---SRDKTIKVWDVETGKCLTTLrgHTDWVNSVA----FSPDGTFVA- 151

                        170
                 ....*....|....*...
gi 157412328 336 CGKGDSSIRYFEITDESP 353
Cdd:cd00200  152 SSSQDGTIKLWDLRTGKC 169
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 131-161 1.29e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.29e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 157412328   131 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVW 161
Cdd:smart00320  10 GHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
128-161 7.53e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 7.53e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 157412328  128 TVCGHTGPVLDIDWCPhNDQVIASGSEDCTVMVW 161
Cdd:pfam00400   6 TLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 174-212 1.54e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.54e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 157412328   174 EPVVILEGHSKRVGIVAWHPTaRNVLLSAGCDNAIIIWN 212
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 226-255 2.60e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 2.60e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 157412328   226 HSDMIYNVSWNRNGSLICTASKDKKVRVID 255
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 118-162 4.69e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.32  E-value: 4.69e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 157412328 118 KTGRIDKsypTVCGHTGPVLDIDWCPHNdQVIASGSEDCTVMVWQ 162
Cdd:cd00200  249 RTGECVQ---TLSGHTNSVTSLAWSPDG-KRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
174-212 7.06e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 7.06e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 157412328  174 EPVVILEGHSKRVGIVAWHPTaRNVLLSAGCDNAIIIWN 212
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
226-255 8.42e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 8.42e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 157412328  226 HSDMIYNVSWNRNGSLICTASKDKKVRVID 255
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 141-238 1.48e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.03  E-value: 1.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157412328  141 WCPHNDqVIASGSEDCTV--------MVWQIPengltlsltepvviLEGHSKRVGIVAWHPTARnVLLSAGCDNAIIIWN 212
Cdd:pfam12894   3 WCPTMD-LIALATEDGELllhrlnwqRVWTLS--------------PDKEDLEVTSLAWRPDGK-LLAVGYSDGTVRLLD 66

                          90       100
                  ....*....|....*....|....*.
gi 157412328  213 VGTGEALINLdDMHSDMIYNVSWNRN 238
Cdd:pfam12894  67 AENGKIVHHF-SAGSDLITCLGWGEN 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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