NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|156766047|ref|NP_001096618|]
View 

GRB10-interacting GYF protein 2 isoform c [Homo sapiens]

Protein Classification

GYF domain-containing protein( domain architecture ID 10049341)

GYF (glycine-tyrosine-phenylalanine) domain-containing protein similar to Arabidopsis thaliana protein ESSENTIAL FOR POTEXVIRUS ACCUMULATION 1, a translational repressor involved in the negative regulation of immune receptor accumulation via the inhibition of nucleotide-binding leucine-rich repeat (NLR) receptor mediated defense

CATH:  3.30.1490.40
Gene Ontology:  GO:0005515
PubMed:  10404223|16403013
SCOP:  4001496

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GYF cd00072
GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and ...
 527-582 7.77e-23

GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.


:

Pssm-ID: 238027  Cd Length: 57  Bit Score: 92.76  E-value: 7.77e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 156766047  527 MQKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSLLVKRA-CDESFQPLGDIMKMWG 582
Cdd:cd00072     1 EVQWFYKDPQGEIQGPFSASQMLQWYQAGYFPDGLQVRRLdNGGEFYTLGDILFDLG 57
 
Name Accession Description Interval E-value
GYF cd00072
GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and ...
 527-582 7.77e-23

GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.


Pssm-ID: 238027  Cd Length: 57  Bit Score: 92.76  E-value: 7.77e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 156766047  527 MQKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSLLVKRA-CDESFQPLGDIMKMWG 582
Cdd:cd00072     1 EVQWFYKDPQGEIQGPFSASQMLQWYQAGYFPDGLQVRRLdNGGEFYTLGDILFDLG 57
GYF smart00444
Contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding protein. ...
 528-583 5.01e-22

Contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding protein. Contains conserved Gly-Tyr-Phe residues.


Pssm-ID: 214666  Cd Length: 56  Bit Score: 90.47  E-value: 5.01e-22
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 156766047    528 QKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSLLVKRACDESFQPLGDIMKMWGR 583
Cdd:smart00444    1 VLWLYKDPDGEIQGPFTASQMSQWYQAGYFPDSLQIKRLNEPPYETLGDLDRLLGL 56
GYF pfam02213
GYF domain; The GYF domain is named because of the presence of Gly-Tyr-Phe residues. The GYF ...
 530-574 8.90e-22

GYF domain; The GYF domain is named because of the presence of Gly-Tyr-Phe residues. The GYF domain is a proline-binding domain in CD2-binding protein Swiss:O95400.


Pssm-ID: 460496  Cd Length: 45  Bit Score: 89.18  E-value: 8.90e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 156766047   530 WYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSLLVKRACDESFQPL 574
Cdd:pfam02213    1 WEYKDPQGEVQGPFSSAEMQEWYKAGYFPDDLPVRRVGDTEFYPL 45
 
Name Accession Description Interval E-value
GYF cd00072
GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and ...
 527-582 7.77e-23

GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.


Pssm-ID: 238027  Cd Length: 57  Bit Score: 92.76  E-value: 7.77e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 156766047  527 MQKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSLLVKRA-CDESFQPLGDIMKMWG 582
Cdd:cd00072     1 EVQWFYKDPQGEIQGPFSASQMLQWYQAGYFPDGLQVRRLdNGGEFYTLGDILFDLG 57
GYF smart00444
Contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding protein. ...
 528-583 5.01e-22

Contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding protein. Contains conserved Gly-Tyr-Phe residues.


Pssm-ID: 214666  Cd Length: 56  Bit Score: 90.47  E-value: 5.01e-22
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 156766047    528 QKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSLLVKRACDESFQPLGDIMKMWGR 583
Cdd:smart00444    1 VLWLYKDPDGEIQGPFTASQMSQWYQAGYFPDSLQIKRLNEPPYETLGDLDRLLGL 56
GYF pfam02213
GYF domain; The GYF domain is named because of the presence of Gly-Tyr-Phe residues. The GYF ...
 530-574 8.90e-22

GYF domain; The GYF domain is named because of the presence of Gly-Tyr-Phe residues. The GYF domain is a proline-binding domain in CD2-binding protein Swiss:O95400.


Pssm-ID: 460496  Cd Length: 45  Bit Score: 89.18  E-value: 8.90e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 156766047   530 WYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSLLVKRACDESFQPL 574
Cdd:pfam02213    1 WEYKDPQGEVQGPFSSAEMQEWYKAGYFPDDLPVRRVGDTEFYPL 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH