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Conserved domains on  [gi|156630995|ref|NP_001096124|]
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neurotrophin-3 isoform 1 preproprotein [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
NTF3_N pfam19338
Neutrophin-3 N-terminus; This family represents the N-terminal region of neutrophin-3 (NTF3) ...
33-146 7.39e-79

Neutrophin-3 N-terminus; This family represents the N-terminal region of neutrophin-3 (NTF3) which contains two precursor homology regions located upstream of the mature NTF3 sequence. These regions play important and specific roles in the folding, processing and transport of neurotrophic factors.


:

Pssm-ID: 437170  Cd Length: 114  Bit Score: 233.88  E-value: 7.39e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156630995   33 NMDQRSLPEDSLNSLIIKLIQADILKNKLSKQMVDVKENYQSTLPKAEAPREPERGGPAKSAFQPVIAMDTELLRQQRRY 112
Cdd:pfam19338   1 NMDQRSLPEDSLNSLIIKLIQADLLKNKTSKQMVDVKENYQSTLPKPEAPLEPDGDENAKSDFQPVISLDTELLRQQRRY 80
                          90       100       110
                  ....*....|....*....|....*....|....
gi 156630995  113 NSPRVLLSDSTPLEPPPLYLMEDYVGSPVVANRT 146
Cdd:pfam19338  81 NSPRVLLSDSTPLEPPPLYLMEDFVGNSPVGNRT 114
NGF pfam00243
Nerve growth factor family;
157-268 7.23e-74

Nerve growth factor family;


:

Pssm-ID: 459728  Cd Length: 112  Bit Score: 221.06  E-value: 7.23e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156630995  157 SHRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEA-RPVKNGCRGIDDKHWNSQCKTSQT 235
Cdd:pfam00243   1 SHRGEYSVCDSVSTWVTNKTTAVDIRGNEVTVLGEVKTNNGVLKQYFFETKCRAGgPGGGSGCRGIDKRHWNSYCKTKQS 80
                          90       100       110
                  ....*....|....*....|....*....|...
gi 156630995  236 YVRALTSENNKlVGWRWIRIDTSCVCALSRKIG 268
Cdd:pfam00243  81 FVRALTIDKNK-VGWRWIRIDTSCVCVLSRKSG 112
 
Name Accession Description Interval E-value
NTF3_N pfam19338
Neutrophin-3 N-terminus; This family represents the N-terminal region of neutrophin-3 (NTF3) ...
33-146 7.39e-79

Neutrophin-3 N-terminus; This family represents the N-terminal region of neutrophin-3 (NTF3) which contains two precursor homology regions located upstream of the mature NTF3 sequence. These regions play important and specific roles in the folding, processing and transport of neurotrophic factors.


Pssm-ID: 437170  Cd Length: 114  Bit Score: 233.88  E-value: 7.39e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156630995   33 NMDQRSLPEDSLNSLIIKLIQADILKNKLSKQMVDVKENYQSTLPKAEAPREPERGGPAKSAFQPVIAMDTELLRQQRRY 112
Cdd:pfam19338   1 NMDQRSLPEDSLNSLIIKLIQADLLKNKTSKQMVDVKENYQSTLPKPEAPLEPDGDENAKSDFQPVISLDTELLRQQRRY 80
                          90       100       110
                  ....*....|....*....|....*....|....
gi 156630995  113 NSPRVLLSDSTPLEPPPLYLMEDYVGSPVVANRT 146
Cdd:pfam19338  81 NSPRVLLSDSTPLEPPPLYLMEDFVGNSPVGNRT 114
NGF pfam00243
Nerve growth factor family;
157-268 7.23e-74

Nerve growth factor family;


Pssm-ID: 459728  Cd Length: 112  Bit Score: 221.06  E-value: 7.23e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156630995  157 SHRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEA-RPVKNGCRGIDDKHWNSQCKTSQT 235
Cdd:pfam00243   1 SHRGEYSVCDSVSTWVTNKTTAVDIRGNEVTVLGEVKTNNGVLKQYFFETKCRAGgPGGGSGCRGIDKRHWNSYCKTKQS 80
                          90       100       110
                  ....*....|....*....|....*....|...
gi 156630995  236 YVRALTSENNKlVGWRWIRIDTSCVCALSRKIG 268
Cdd:pfam00243  81 FVRALTIDKNK-VGWRWIRIDTSCVCVLSRKSG 112
NGF smart00140
Nerve growth factor (NGF or beta-NGF); NGF is important for the development and maintenance of ...
157-262 6.86e-71

Nerve growth factor (NGF or beta-NGF); NGF is important for the development and maintenance of the sympathetic and sensory nervous systems.


Pssm-ID: 128445  Cd Length: 106  Bit Score: 213.12  E-value: 6.86e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156630995   157 SHRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEARPVKNGCRGIDDKHWNSQCKTSQTY 236
Cdd:smart00140   1 SHRGEYSVCDSISVWVTDKTTATDISGNEVTVLGEVPVNNGPLKQYFYETRCKSPNPVKSGCRGIDSRHWNSQCKTTQTY 80
                           90       100
                   ....*....|....*....|....*.
gi 156630995   237 VRALTSENNKLVGWRWIRIDTSCVCA 262
Cdd:smart00140  81 VRALTSDANKRVGWRFIRIDTACVCV 106
 
Name Accession Description Interval E-value
NTF3_N pfam19338
Neutrophin-3 N-terminus; This family represents the N-terminal region of neutrophin-3 (NTF3) ...
33-146 7.39e-79

Neutrophin-3 N-terminus; This family represents the N-terminal region of neutrophin-3 (NTF3) which contains two precursor homology regions located upstream of the mature NTF3 sequence. These regions play important and specific roles in the folding, processing and transport of neurotrophic factors.


Pssm-ID: 437170  Cd Length: 114  Bit Score: 233.88  E-value: 7.39e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156630995   33 NMDQRSLPEDSLNSLIIKLIQADILKNKLSKQMVDVKENYQSTLPKAEAPREPERGGPAKSAFQPVIAMDTELLRQQRRY 112
Cdd:pfam19338   1 NMDQRSLPEDSLNSLIIKLIQADLLKNKTSKQMVDVKENYQSTLPKPEAPLEPDGDENAKSDFQPVISLDTELLRQQRRY 80
                          90       100       110
                  ....*....|....*....|....*....|....
gi 156630995  113 NSPRVLLSDSTPLEPPPLYLMEDYVGSPVVANRT 146
Cdd:pfam19338  81 NSPRVLLSDSTPLEPPPLYLMEDFVGNSPVGNRT 114
NGF pfam00243
Nerve growth factor family;
157-268 7.23e-74

Nerve growth factor family;


Pssm-ID: 459728  Cd Length: 112  Bit Score: 221.06  E-value: 7.23e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156630995  157 SHRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEA-RPVKNGCRGIDDKHWNSQCKTSQT 235
Cdd:pfam00243   1 SHRGEYSVCDSVSTWVTNKTTAVDIRGNEVTVLGEVKTNNGVLKQYFFETKCRAGgPGGGSGCRGIDKRHWNSYCKTKQS 80
                          90       100       110
                  ....*....|....*....|....*....|...
gi 156630995  236 YVRALTSENNKlVGWRWIRIDTSCVCALSRKIG 268
Cdd:pfam00243  81 FVRALTIDKNK-VGWRWIRIDTSCVCVLSRKSG 112
NGF smart00140
Nerve growth factor (NGF or beta-NGF); NGF is important for the development and maintenance of ...
157-262 6.86e-71

Nerve growth factor (NGF or beta-NGF); NGF is important for the development and maintenance of the sympathetic and sensory nervous systems.


Pssm-ID: 128445  Cd Length: 106  Bit Score: 213.12  E-value: 6.86e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156630995   157 SHRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEARPVKNGCRGIDDKHWNSQCKTSQTY 236
Cdd:smart00140   1 SHRGEYSVCDSISVWVTDKTTATDISGNEVTVLGEVPVNNGPLKQYFYETRCKSPNPVKSGCRGIDSRHWNSQCKTTQTY 80
                           90       100
                   ....*....|....*....|....*.
gi 156630995   237 VRALTSENNKLVGWRWIRIDTSCVCA 262
Cdd:smart00140  81 VRALTSDANKRVGWRFIRIDTACVCV 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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