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Conserved domains on  [gi|156139137|ref|NP_001095839|]
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D-glutamate cyclase, mitochondrial isoform c [Homo sapiens]

Protein Classification

DUF4392 domain-containing protein; putative hydro-lyase( domain architecture ID 10237983)

DUF4392 domain-containing protein similar to Thermococcus onnurineus TON_0340; putative hydro-lyase belonging to the D-glutamate cyclase family (formerly called DUF1445); similar to Bacillus subtilis putative hydro-lyase YcsI

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DUF4392 pfam14336
Domain of unknown function (DUF4392); This family of proteins is found in bacteria, archaea ...
286-557 1.68e-106

Domain of unknown function (DUF4392); This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 282 and 585 amino acids in length. There are two completely conserved G residues that may be functionally important.


:

Pssm-ID: 464140  Cd Length: 291  Bit Score: 321.15  E-value: 1.68e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139137  286 LESMIGIDPGNRGIGHLLCKDELLKASLSLSHAR-SVLITTGFPTHFNHepPEETDGPPGAVALVAFLQALEKEVAIIVD 364
Cdd:pfam14336   1 LETLIARDPGGRGIKALLYPGELLKAALPLSHAAgSVLITTGFPVPPTH--PAETDGPPGAIALARALQALGKKVVIVTD 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139137  365 qrawNLHQKIVEDAVEQGVLKTQIPIlTYQGGSVEAAQAFLCKNGDPQ---------TPRFDHLVAIERAGRAADGNYYN 435
Cdd:pfam14336  79 ----ELNEKAVEAAVEVGVLKTPVPI-TYQDGSREAAVVFLTKDGDGAeaqaeelleKYKPDHLIAIERPGRAADGNYHN 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139137  436 ARKMNIKHLVDPIDDLFLAAKKIpGISSTG----------------------------------------VSNWGGYALA 475
Cdd:pfam14336 154 MRGINITHLVAPLDDLFLLAKKI-GIPTIGigdggnelgmgnvkeavkkhvpngekiacvvaadflitagVSNWGGYALA 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139137  476 CALYILYSCAvhsqylrkavgpsrapgdqawtQALPSVIKEEKMLGILVQHKVRSGVSGIVGMEVDGLPFHnTHAEMIQK 555
Cdd:pfam14336 233 AALSLLSGCP----------------------SLLPSVEKEEEMLEALVEAGAVDGVTGELEPSVDGLPFE-EHAEILKE 289

                  ..
gi 156139137  556 LV 557
Cdd:pfam14336 290 LR 291
D-Glu_cyclase super family cl01790
D-glutamate cyclase; This family includes mitochondrial D-glutamate cyclase which converts ...
118-243 4.23e-59

D-glutamate cyclase; This family includes mitochondrial D-glutamate cyclase which converts D-glutamate to 5-oxo-D-proline. This family also includes numerous uncharacterized proteins from bacteria.


The actual alignment was detected with superfamily member pfam07286:

Pssm-ID: 470346  Cd Length: 143  Bit Score: 193.06  E-value: 4.23e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139137  118 VAFFLGCSFSLEEALEKAGLPRRDPAGHS-----QTTVPCVTHAGFCCPLVVTMRPIPKDKLEGLVRACCSLG------- 185
Cdd:pfam07286   1 VTFLIGCSFSFEEALLEAGIPVRHIEQGRnvpmyRTNIPCCPAGPFSGPMVVSMRPIPKDKVERAVQITSRFPavhgapv 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 156139137  186 -----ELLGIKELSKPAYGDAMVCPPGEVPVFWPSPLTSLGAVSSCETPLAFASIPGCTVMTD 243
Cdd:pfam07286  81 higdpALIGIKDLSKPDYGDPVEIQPGEVPVFWACGVTPQEAVMSAKPPLAITHAPGHMFVTD 143
 
Name Accession Description Interval E-value
DUF4392 pfam14336
Domain of unknown function (DUF4392); This family of proteins is found in bacteria, archaea ...
286-557 1.68e-106

Domain of unknown function (DUF4392); This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 282 and 585 amino acids in length. There are two completely conserved G residues that may be functionally important.


Pssm-ID: 464140  Cd Length: 291  Bit Score: 321.15  E-value: 1.68e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139137  286 LESMIGIDPGNRGIGHLLCKDELLKASLSLSHAR-SVLITTGFPTHFNHepPEETDGPPGAVALVAFLQALEKEVAIIVD 364
Cdd:pfam14336   1 LETLIARDPGGRGIKALLYPGELLKAALPLSHAAgSVLITTGFPVPPTH--PAETDGPPGAIALARALQALGKKVVIVTD 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139137  365 qrawNLHQKIVEDAVEQGVLKTQIPIlTYQGGSVEAAQAFLCKNGDPQ---------TPRFDHLVAIERAGRAADGNYYN 435
Cdd:pfam14336  79 ----ELNEKAVEAAVEVGVLKTPVPI-TYQDGSREAAVVFLTKDGDGAeaqaeelleKYKPDHLIAIERPGRAADGNYHN 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139137  436 ARKMNIKHLVDPIDDLFLAAKKIpGISSTG----------------------------------------VSNWGGYALA 475
Cdd:pfam14336 154 MRGINITHLVAPLDDLFLLAKKI-GIPTIGigdggnelgmgnvkeavkkhvpngekiacvvaadflitagVSNWGGYALA 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139137  476 CALYILYSCAvhsqylrkavgpsrapgdqawtQALPSVIKEEKMLGILVQHKVRSGVSGIVGMEVDGLPFHnTHAEMIQK 555
Cdd:pfam14336 233 AALSLLSGCP----------------------SLLPSVEKEEEMLEALVEAGAVDGVTGELEPSVDGLPFE-EHAEILKE 289

                  ..
gi 156139137  556 LV 557
Cdd:pfam14336 290 LR 291
D-Glu_cyclase pfam07286
D-glutamate cyclase; This family includes mitochondrial D-glutamate cyclase which converts ...
118-243 4.23e-59

D-glutamate cyclase; This family includes mitochondrial D-glutamate cyclase which converts D-glutamate to 5-oxo-D-proline. This family also includes numerous uncharacterized proteins from bacteria.


Pssm-ID: 462133  Cd Length: 143  Bit Score: 193.06  E-value: 4.23e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139137  118 VAFFLGCSFSLEEALEKAGLPRRDPAGHS-----QTTVPCVTHAGFCCPLVVTMRPIPKDKLEGLVRACCSLG------- 185
Cdd:pfam07286   1 VTFLIGCSFSFEEALLEAGIPVRHIEQGRnvpmyRTNIPCCPAGPFSGPMVVSMRPIPKDKVERAVQITSRFPavhgapv 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 156139137  186 -----ELLGIKELSKPAYGDAMVCPPGEVPVFWPSPLTSLGAVSSCETPLAFASIPGCTVMTD 243
Cdd:pfam07286  81 higdpALIGIKDLSKPDYGDPVEIQPGEVPVFWACGVTPQEAVMSAKPPLAITHAPGHMFVTD 143
 
Name Accession Description Interval E-value
DUF4392 pfam14336
Domain of unknown function (DUF4392); This family of proteins is found in bacteria, archaea ...
286-557 1.68e-106

Domain of unknown function (DUF4392); This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 282 and 585 amino acids in length. There are two completely conserved G residues that may be functionally important.


Pssm-ID: 464140  Cd Length: 291  Bit Score: 321.15  E-value: 1.68e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139137  286 LESMIGIDPGNRGIGHLLCKDELLKASLSLSHAR-SVLITTGFPTHFNHepPEETDGPPGAVALVAFLQALEKEVAIIVD 364
Cdd:pfam14336   1 LETLIARDPGGRGIKALLYPGELLKAALPLSHAAgSVLITTGFPVPPTH--PAETDGPPGAIALARALQALGKKVVIVTD 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139137  365 qrawNLHQKIVEDAVEQGVLKTQIPIlTYQGGSVEAAQAFLCKNGDPQ---------TPRFDHLVAIERAGRAADGNYYN 435
Cdd:pfam14336  79 ----ELNEKAVEAAVEVGVLKTPVPI-TYQDGSREAAVVFLTKDGDGAeaqaeelleKYKPDHLIAIERPGRAADGNYHN 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139137  436 ARKMNIKHLVDPIDDLFLAAKKIpGISSTG----------------------------------------VSNWGGYALA 475
Cdd:pfam14336 154 MRGINITHLVAPLDDLFLLAKKI-GIPTIGigdggnelgmgnvkeavkkhvpngekiacvvaadflitagVSNWGGYALA 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139137  476 CALYILYSCAvhsqylrkavgpsrapgdqawtQALPSVIKEEKMLGILVQHKVRSGVSGIVGMEVDGLPFHnTHAEMIQK 555
Cdd:pfam14336 233 AALSLLSGCP----------------------SLLPSVEKEEEMLEALVEAGAVDGVTGELEPSVDGLPFE-EHAEILKE 289

                  ..
gi 156139137  556 LV 557
Cdd:pfam14336 290 LR 291
D-Glu_cyclase pfam07286
D-glutamate cyclase; This family includes mitochondrial D-glutamate cyclase which converts ...
118-243 4.23e-59

D-glutamate cyclase; This family includes mitochondrial D-glutamate cyclase which converts D-glutamate to 5-oxo-D-proline. This family also includes numerous uncharacterized proteins from bacteria.


Pssm-ID: 462133  Cd Length: 143  Bit Score: 193.06  E-value: 4.23e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139137  118 VAFFLGCSFSLEEALEKAGLPRRDPAGHS-----QTTVPCVTHAGFCCPLVVTMRPIPKDKLEGLVRACCSLG------- 185
Cdd:pfam07286   1 VTFLIGCSFSFEEALLEAGIPVRHIEQGRnvpmyRTNIPCCPAGPFSGPMVVSMRPIPKDKVERAVQITSRFPavhgapv 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 156139137  186 -----ELLGIKELSKPAYGDAMVCPPGEVPVFWPSPLTSLGAVSSCETPLAFASIPGCTVMTD 243
Cdd:pfam07286  81 higdpALIGIKDLSKPDYGDPVEIQPGEVPVFWACGVTPQEAVMSAKPPLAITHAPGHMFVTD 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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