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Conserved domains on  [gi|156416007|ref|NP_001095123|]
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COMM domain-containing protein 9 isoform 2 [Homo sapiens]

Protein Classification

COMM domain-containing protein 9( domain architecture ID 10140837)

COMM domain-containing protein 9 (COMMD9) may modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes, down-regulate activation of NF-kappa-B, and modulate Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits

Gene Ontology:  GO:0006814|GO:0042632
PubMed:  15799966
SCOP:  4005215

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Commd9 cd04757
COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of ...
 48-155 1.05e-63

COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


:

Pssm-ID: 240105  Cd Length: 108  Bit Score: 190.47  E-value: 1.05e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156416007  48 FHQNLKNLLTKIILEHVSTWRTEAQANQISLPRLVDLDWRVDIKTSSDSISRMAVPTCLLQMKIQEDPSLCGDKPSISAV 127
Cdd:cd04757    1 FHSNLKNLLTKIILENRDKWRSEASENQISLPKLVDHDWRVDIKTSSDSLGRMAVPTCLLQMKIQEAPSLCGLLPPLSTL 80

                         90       100
                 ....*....|....*....|....*...
gi 156416007 128 TVELSKETLDTMLDGLGRIRDQLSAVAS 155
Cdd:cd04757   81 TMELSKETLDTMLDGLGRIRDQLSAVAQ 108
 
Name Accession Description Interval E-value
Commd9 cd04757
COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of ...
 48-155 1.05e-63

COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240105  Cd Length: 108  Bit Score: 190.47  E-value: 1.05e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156416007  48 FHQNLKNLLTKIILEHVSTWRTEAQANQISLPRLVDLDWRVDIKTSSDSISRMAVPTCLLQMKIQEDPSLCGDKPSISAV 127
Cdd:cd04757    1 FHSNLKNLLTKIILENRDKWRSEASENQISLPKLVDHDWRVDIKTSSDSLGRMAVPTCLLQMKIQEAPSLCGLLPPLSTL 80

                         90       100
                 ....*....|....*....|....*...
gi 156416007 128 TVELSKETLDTMLDGLGRIRDQLSAVAS 155
Cdd:cd04757   81 TMELSKETLDTMLDGLGRIRDQLSAVAQ 108
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 77-146 6.84e-16

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 67.57  E-value: 6.84e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156416007   77 SLPRLVDLDWRVDIKTSSDSISRMAVPTCLLQMKIQEdpslcgDKPSISAVTVELSKETLDTMLDGLGRI 146
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSD------GDGSSEEVTFELSKEQLQDLLNELEEA 64
 
Name Accession Description Interval E-value
Commd9 cd04757
COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of ...
 48-155 1.05e-63

COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240105  Cd Length: 108  Bit Score: 190.47  E-value: 1.05e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156416007  48 FHQNLKNLLTKIILEHVSTWRTEAQANQISLPRLVDLDWRVDIKTSSDSISRMAVPTCLLQMKIQEDPSLCGDKPSISAV 127
Cdd:cd04757    1 FHSNLKNLLTKIILENRDKWRSEASENQISLPKLVDHDWRVDIKTSSDSLGRMAVPTCLLQMKIQEAPSLCGLLPPLSTL 80

                         90       100
                 ....*....|....*....|....*...
gi 156416007 128 TVELSKETLDTMLDGLGRIRDQLSAVAS 155
Cdd:cd04757   81 TMELSKETLDTMLDGLGRIRDQLSAVAQ 108
Commd cd04748
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 55-150 9.92e-22

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


Pssm-ID: 240096  Cd Length: 87  Bit Score: 83.13  E-value: 9.92e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156416007  55 LLTKIILEHVSTWRTEAQanqiSLPRLVDLDWRVDIKTSSDSISRMAVPTCLLQMKIQEdpslcGDKPSISAVTVELSKE 134
Cdd:cd04748    1 LLTENKAEIEELLSKQSL----SLPQLVDFDWRLDVQISSSSLAKVKQPTILVQLKLQV-----GDNNSSEKICFEMTKE 71

                         90
                 ....*....|....*.
gi 156416007 135 TLDTMLDGLGRIRDQL 150
Cdd:cd04748   72 ELQNFLNKLKKIKAQL 87
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 77-146 6.84e-16

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 67.57  E-value: 6.84e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156416007   77 SLPRLVDLDWRVDIKTSSDSISRMAVPTCLLQMKIQEdpslcgDKPSISAVTVELSKETLDTMLDGLGRI 146
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSD------GDGSSEEVTFELSKEQLQDLLNELEEA 64
Commd8 cd04756
COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of ...
 10-143 2.47e-06

COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240104 [Multi-domain]  Cd Length: 176  Bit Score: 45.10  E-value: 2.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156416007  10 AALQSLLKLLQALHRLTRLVAFRDLSSAEAILALfpenfhQNLKNLLTKIILEHVSTWRTE------AQANQISLPRLVD 83
Cdd:cd04756   40 WSLEEWTEVLESLATLFKQAVGKNSNDEEAKAQL------SDLSSSHQEALLKCVKSRKEEirqalvNKTNSISSAQLQD 113

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 156416007  84 LDWRVDIKTSSDSISRMAVPTCLLQMKIQEDPSLcgdKPsisaVTVELSKETLDTMLDGL 143
Cdd:cd04756  114 FDWQLKLALSSDKLSSLQEPLLNLDLDVKENGIL---KP----VSIEMNKEELQNLISSL 166
Commd5_HCaRG cd04753
COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated ...
 77-110 2.57e-04

COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated gene). HCaRG is a nuclear protein that might be involved in cell proliferation; it is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240101  Cd Length: 110  Bit Score: 38.58  E-value: 2.57e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 156416007  77 SLPRLVDLDWRVDIKTSSDSISRMAVPTCLLQMK 110
Cdd:cd04753   34 RLPHLEDFKWRVDVAISTSSLSRVLQPSILMEMK 67
Commd2 cd04750
COMM_Domain containing protein 2. The COMM Domain is found at the C-terminus of a variety of ...
 34-116 2.58e-04

COMM_Domain containing protein 2. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240098 [Multi-domain]  Cd Length: 166  Bit Score: 39.22  E-value: 2.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156416007  34 LSSAEAILALFPENFHQNLKNLLTKIILEHVSTWRTEAQANQISLPRLVDLDWRVDIKTSSDSISRMAVPTCLLQMKIQE 113
Cdd:cd04750   52 LSERDFQDSIEFLGFSDDLNEILLQLYESNRKEIRNILKELSPDLPHYHNLEWRLDVQIASRSLRSQVKPVITMKLHLED 131


                 ...
gi 156416007 114 DPS 116
Cdd:cd04750  132 ENK 134
Commd1_MURR1 cd04749
COMM_Domain containing protein 1, also called Murr1. Murr1/Commd1 is a protein involved in ...
 79-152 1.33e-03

COMM_Domain containing protein 1, also called Murr1. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240097 [Multi-domain]  Cd Length: 174  Bit Score: 37.11  E-value: 1.33e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 156416007  79 PRLVDLDWRVDIKTSSDSISRMAVPTCLLQMKIQEDpslcGDKPSIsaVTVELSKETLDTMLDGLGRIRDQLSA 152
Cdd:cd04749  106 NSLRGLSWRVDLKTQSRHIAQINSPVAIVELELGKT----GQESEF--VCLEFDEAKVNRVLKQLAEIQESLDA 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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