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Conserved domains on  [gi|153792645|ref|NP_001093353|]
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uncharacterized protein LOC100101296 [Xenopus laevis]

Protein Classification

PAPA-1 and zf-HIT domain-containing protein( domain architecture ID 10521558)

PAPA-1 and zf-HIT domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-HIT_IN80B cd23021
zinc finger HIT (zf-HIT) found in INO80 complex subunit B (INO80B) and similar proteins; ...
 275-307 6.74e-17

zinc finger HIT (zf-HIT) found in INO80 complex subunit B (INO80B) and similar proteins; INO80B, also called high mobility group AT-hook 1-like 4 (HMGA1L4), or IES2 homolog, or PAP-1-associated protein 1 (PAPA-1), or zinc finger HIT domain-containing protein 4 (ZNHIT4), is a nucleolar protein that induces growth and cell cycle arrests at the G1 phase of the cell cycle. It is a core component of the chromatin remodeling INO80 complex, which is involved in transcriptional regulation, DNA replication and probably DNA repair. INO80B harbors a zf-HIT domain which is characterized by a fold in "treble-clef" through interleaved CCCC and CCHC ZnF motifs that both bind a zinc atom. The yeast counterpart of INO80B is Ies2p (Ino eighty subunit 2), which doesn't have zf-HIT domain.


:

Pssm-ID: 467793  Cd Length: 33  Bit Score: 72.69  E-value: 6.74e-17
                         10        20        30
                 ....*....|....*....|....*....|...
gi 153792645 275 TLCGVPGCSNPKKYSCSHTRTPLCSLECYRKNL 307
Cdd:cd23021    1 ELCSVPGCTNPKKYRCSKTGVPVCSLECYKKNL 33
PAPA-1 pfam04795
PAPA-1-like conserved region; Family of proteins with a conserved region found in PAPA-1, a ...
 186-256 2.44e-12

PAPA-1-like conserved region; Family of proteins with a conserved region found in PAPA-1, a PAP-1 binding protein.


:

Pssm-ID: 461431 [Multi-domain]  Cd Length: 78  Bit Score: 61.43  E-value: 2.44e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 153792645  186 EMLVKREEKARKRRLQAAKKAEESKKQTIERL-----TKTSKSRGAKAPRERRGR--QPPCPMIRYQDSAHVISLSFP 256
Cdd:pfam04795   1 EQALKRAEMARRRKNQSEKRLEEEKAETINKLlkkqaPKRKAAAEAELPENEATEpyRPNPQMIRWVSNPDGTTVSVP 78
 
Name Accession Description Interval E-value
zf-HIT_IN80B cd23021
zinc finger HIT (zf-HIT) found in INO80 complex subunit B (INO80B) and similar proteins; ...
 275-307 6.74e-17

zinc finger HIT (zf-HIT) found in INO80 complex subunit B (INO80B) and similar proteins; INO80B, also called high mobility group AT-hook 1-like 4 (HMGA1L4), or IES2 homolog, or PAP-1-associated protein 1 (PAPA-1), or zinc finger HIT domain-containing protein 4 (ZNHIT4), is a nucleolar protein that induces growth and cell cycle arrests at the G1 phase of the cell cycle. It is a core component of the chromatin remodeling INO80 complex, which is involved in transcriptional regulation, DNA replication and probably DNA repair. INO80B harbors a zf-HIT domain which is characterized by a fold in "treble-clef" through interleaved CCCC and CCHC ZnF motifs that both bind a zinc atom. The yeast counterpart of INO80B is Ies2p (Ino eighty subunit 2), which doesn't have zf-HIT domain.


Pssm-ID: 467793  Cd Length: 33  Bit Score: 72.69  E-value: 6.74e-17
                         10        20        30
                 ....*....|....*....|....*....|...
gi 153792645 275 TLCGVPGCSNPKKYSCSHTRTPLCSLECYRKNL 307
Cdd:cd23021    1 ELCSVPGCTNPKKYRCSKTGVPVCSLECYKKNL 33
PAPA-1 pfam04795
PAPA-1-like conserved region; Family of proteins with a conserved region found in PAPA-1, a ...
 186-256 2.44e-12

PAPA-1-like conserved region; Family of proteins with a conserved region found in PAPA-1, a PAP-1 binding protein.


Pssm-ID: 461431 [Multi-domain]  Cd Length: 78  Bit Score: 61.43  E-value: 2.44e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 153792645  186 EMLVKREEKARKRRLQAAKKAEESKKQTIERL-----TKTSKSRGAKAPRERRGR--QPPCPMIRYQDSAHVISLSFP 256
Cdd:pfam04795   1 EQALKRAEMARRRKNQSEKRLEEEKAETINKLlkkqaPKRKAAAEAELPENEATEpyRPNPQMIRWVSNPDGTTVSVP 78
zf-HIT pfam04438
HIT zinc finger; This presumed zinc finger contains up to 6 cysteine residues that could ...
 276-304 1.44e-07

HIT zinc finger; This presumed zinc finger contains up to 6 cysteine residues that could coordinate zinc. The domain is named after the HIT protein. This domain is also found in the Thyroid receptor interacting protein 3 (TRIP-3) that specifically interact with the ligand binding domain of the thyroid receptor.


Pssm-ID: 461310  Cd Length: 30  Bit Score: 46.86  E-value: 1.44e-07
                          10        20
                  ....*....|....*....|....*....
gi 153792645  276 LCGVpgCSNPKKYSCSHTRTPLCSLECYR 304
Cdd:pfam04438   4 LCSV--CGNPSKYRCPRCGVRYCSLECYK 30
 
Name Accession Description Interval E-value
zf-HIT_IN80B cd23021
zinc finger HIT (zf-HIT) found in INO80 complex subunit B (INO80B) and similar proteins; ...
 275-307 6.74e-17

zinc finger HIT (zf-HIT) found in INO80 complex subunit B (INO80B) and similar proteins; INO80B, also called high mobility group AT-hook 1-like 4 (HMGA1L4), or IES2 homolog, or PAP-1-associated protein 1 (PAPA-1), or zinc finger HIT domain-containing protein 4 (ZNHIT4), is a nucleolar protein that induces growth and cell cycle arrests at the G1 phase of the cell cycle. It is a core component of the chromatin remodeling INO80 complex, which is involved in transcriptional regulation, DNA replication and probably DNA repair. INO80B harbors a zf-HIT domain which is characterized by a fold in "treble-clef" through interleaved CCCC and CCHC ZnF motifs that both bind a zinc atom. The yeast counterpart of INO80B is Ies2p (Ino eighty subunit 2), which doesn't have zf-HIT domain.


Pssm-ID: 467793  Cd Length: 33  Bit Score: 72.69  E-value: 6.74e-17
                         10        20        30
                 ....*....|....*....|....*....|...
gi 153792645 275 TLCGVPGCSNPKKYSCSHTRTPLCSLECYRKNL 307
Cdd:cd23021    1 ELCSVPGCTNPKKYRCSKTGVPVCSLECYKKNL 33
PAPA-1 pfam04795
PAPA-1-like conserved region; Family of proteins with a conserved region found in PAPA-1, a ...
 186-256 2.44e-12

PAPA-1-like conserved region; Family of proteins with a conserved region found in PAPA-1, a PAP-1 binding protein.


Pssm-ID: 461431 [Multi-domain]  Cd Length: 78  Bit Score: 61.43  E-value: 2.44e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 153792645  186 EMLVKREEKARKRRLQAAKKAEESKKQTIERL-----TKTSKSRGAKAPRERRGR--QPPCPMIRYQDSAHVISLSFP 256
Cdd:pfam04795   1 EQALKRAEMARRRKNQSEKRLEEEKAETINKLlkkqaPKRKAAAEAELPENEATEpyRPNPQMIRWVSNPDGTTVSVP 78
zf-HIT pfam04438
HIT zinc finger; This presumed zinc finger contains up to 6 cysteine residues that could ...
 276-304 1.44e-07

HIT zinc finger; This presumed zinc finger contains up to 6 cysteine residues that could coordinate zinc. The domain is named after the HIT protein. This domain is also found in the Thyroid receptor interacting protein 3 (TRIP-3) that specifically interact with the ligand binding domain of the thyroid receptor.


Pssm-ID: 461310  Cd Length: 30  Bit Score: 46.86  E-value: 1.44e-07
                          10        20
                  ....*....|....*....|....*....
gi 153792645  276 LCGVpgCSNPKKYSCSHTRTPLCSLECYR 304
Cdd:pfam04438   4 LCSV--CGNPSKYRCPRCGVRYCSLECYK 30
zf-HIT cd23020
zinc finger HIT (zf-HIT) domain; The zinc finger HIT (zf-HIT) is a novel zinc-binding domain ...
 276-307 1.32e-05

zinc finger HIT (zf-HIT) domain; The zinc finger HIT (zf-HIT) is a novel zinc-binding domain with about 50 amino acids. It is characterized by a fold in "treble-clef" through interleaved CCCC and CCHC zinc finger motifs that both bind a zinc ion. zf-HIT domain may function as a protein-protein interaction domain. It is mainly found in nuclear proteins involved in gene regulation and chromatin remodeling. The zf-HIT family includes six proteins containing zf-HIT domain present in human and three in yeast proteome, all belonging to multimodular RNA/protein complexes.


Pssm-ID: 467792  Cd Length: 31  Bit Score: 41.33  E-value: 1.32e-05
                         10        20        30
                 ....*....|....*....|....*....|..
gi 153792645 276 LCGVPGcSNPKKYSCSHTRTPLCSLECYRKNL 307
Cdd:cd23020    1 TCGICG-GYPGKYKCPRCGVPYCSLECYRKHL 31
zf-HIT_ZNHIT2-3 cd23024
zinc finger HIT (zf-HIT) found in zinc finger HIT domain-containing protein 2 (ZNHIT2), 3 ...
 276-305 2.94e-04

zinc finger HIT (zf-HIT) found in zinc finger HIT domain-containing protein 2 (ZNHIT2), 3 (ZNHIT3) and similar proteins; ZNHIT2 and ZNHIT3 are members of the zf-HIT domain-containing protein family that play crucial roles in various biological processes. ZNHIT2 acts as a bridging factor between the R2TP/PFDL complex and U5 snRNP, while ZNHIT3 interacts specifically with the ligand binding domain of the thyroid receptor and is involved in small nucleolar ribonucleoprotein particle assembly, transcriptional regulation, and snoRNP assembly. ZNHIT3 is also associated with HNF-4alpha and may play a role in MODY, while its dysfunction is linked to PEHO syndrome. Both proteins contain the zf-HIT domain and interact with other proteins through their HIT-type zinc finger in the presence of ATP, ADP, or other factors.


Pssm-ID: 467796 [Multi-domain]  Cd Length: 37  Bit Score: 37.62  E-value: 2.94e-04
                         10        20        30
                 ....*....|....*....|....*....|.
gi 153792645 276 LCGVpgCS-NPKKYSCSHTRTPLCSLECYRK 305
Cdd:cd23024    2 LCGV--CNkNESKYKCPRCNIPYCSLACYKS 30
zf-HIT_DDX59 cd23022
zinc finger HIT (zf-HIT) found in DEAD box protein 59 (DDX59) and similar proteins; DDX59, ...
 282-308 5.91e-04

zinc finger HIT (zf-HIT) found in DEAD box protein 59 (DDX59) and similar proteins; DDX59, also called zinc finger HIT domain-containing protein 5 (ZNHIT5), is a probable ATP-dependent RNA helicase (EC 3.6.4.13) that plays a role in nervous system development and function. It has an important role in lung cancer development through promoting DNA replication. Mutations in DDX59 implicate RNA helicase in the pathogenesis of oral-facial-digital syndrome (OFDS). DDX59 contains a zf-HIT domain which is characterized by a fold in "treble-clef" through interleaved CCCC and CCHC zinc finger motifs that both bind a zinc ion.


Pssm-ID: 467794  Cd Length: 35  Bit Score: 36.84  E-value: 5.91e-04
                         10        20
                 ....*....|....*....|....*..
gi 153792645 282 CSNPKKYSCSHTRTPLCSLECYRKNLQ 308
Cdd:cd23022    9 CGRYANYYCDDTDDPVCSLECKRKHLA 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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