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Conserved domains on  [gi|153792698|ref|NP_001093261|]
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protein SYS1 homolog isoform b [Homo sapiens]

Protein Classification

SYS1 family protein( domain architecture ID 7751)

SYS1 family protein similar to protein SYS1 that is involved in protein trafficking and may serve as a receptor for ARFRP1

Gene Ontology:  GO:0000139|GO:0005802|GO:0034067|GO:0043001|GO:0006895

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SYS1 super family cl10775
Integral membrane protein S linking to the trans Golgi network; Members of this family are ...
 5-76 4.52e-23

Integral membrane protein S linking to the trans Golgi network; Members of this family are integral membrane proteins involved in protein trafficking between the late Golgi and endosome. They may also serve as a receptor for ADP-ribosylation factor-related protein 1 (ARFRP1). Sys1p is a small integral membrane protein with four predicted transmembrane domains that localizes to the Trans Golgi network TGN in yeast and human cells.


The actual alignment was detected with superfamily member pfam09801:

Pssm-ID: 370705  Cd Length: 144  Bit Score: 85.37  E-value: 4.52e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 153792698    5 FRSYVWDPLLILSQIVLMQTVYYGSLGLWLALVDGLVRSSPSLDQMFDAEILGFSTPPGRLSMMSFILNALT 76
Cdd:pfam09801   1 FRQTVWDPLLILSQIVLLQCFYYLTAGVLFYLTALLAGYSFSLDLIFSWHSLDFDTTSGWLLGLAWLLNSLV 72
 
Name Accession Description Interval E-value
SYS1 pfam09801
Integral membrane protein S linking to the trans Golgi network; Members of this family are ...
 5-76 4.52e-23

Integral membrane protein S linking to the trans Golgi network; Members of this family are integral membrane proteins involved in protein trafficking between the late Golgi and endosome. They may also serve as a receptor for ADP-ribosylation factor-related protein 1 (ARFRP1). Sys1p is a small integral membrane protein with four predicted transmembrane domains that localizes to the Trans Golgi network TGN in yeast and human cells.


Pssm-ID: 370705  Cd Length: 144  Bit Score: 85.37  E-value: 4.52e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 153792698    5 FRSYVWDPLLILSQIVLMQTVYYGSLGLWLALVDGLVRSSPSLDQMFDAEILGFSTPPGRLSMMSFILNALT 76
Cdd:pfam09801   1 FRQTVWDPLLILSQIVLLQCFYYLTAGVLFYLTALLAGYSFSLDLIFSWHSLDFDTTSGWLLGLAWLLNSLV 72
 
Name Accession Description Interval E-value
SYS1 pfam09801
Integral membrane protein S linking to the trans Golgi network; Members of this family are ...
 5-76 4.52e-23

Integral membrane protein S linking to the trans Golgi network; Members of this family are integral membrane proteins involved in protein trafficking between the late Golgi and endosome. They may also serve as a receptor for ADP-ribosylation factor-related protein 1 (ARFRP1). Sys1p is a small integral membrane protein with four predicted transmembrane domains that localizes to the Trans Golgi network TGN in yeast and human cells.


Pssm-ID: 370705  Cd Length: 144  Bit Score: 85.37  E-value: 4.52e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 153792698    5 FRSYVWDPLLILSQIVLMQTVYYGSLGLWLALVDGLVRSSPSLDQMFDAEILGFSTPPGRLSMMSFILNALT 76
Cdd:pfam09801   1 FRQTVWDPLLILSQIVLLQCFYYLTAGVLFYLTALLAGYSFSLDLIFSWHSLDFDTTSGWLLGLAWLLNSLV 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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