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Conserved domains on  [gi|148664213|ref|NP_001091989|]
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leucine-rich repeat-containing protein 43 isoform 1 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 171-290 7.95e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 50.55  E-value: 7.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148664213 171 PTLKVLELYGNEISSMECLcaHPPAGLQHLGLGHNKLLGpLESLYVTANHWPNLVSLDLgfndltdlqsmvtslrtlrhl 250
Cdd:cd21340  120 NSLRVLNISGNNIDSLEPL--APLRNLEQLDASNNQISD-LEELLDLLSSWPSLRELDL--------------------- 175

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 148664213 251 rllvlQGNPLALVPYYRGLTIDSLAQLCVLDDITVSPNEK 290
Cdd:cd21340  176 -----TGNPVCKKPKYRDKIILASKSLEVLDGKEITDTER 210
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 171-290 7.95e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.55  E-value: 7.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148664213 171 PTLKVLELYGNEISSMECLcaHPPAGLQHLGLGHNKLLGpLESLYVTANHWPNLVSLDLgfndltdlqsmvtslrtlrhl 250
Cdd:cd21340  120 NSLRVLNISGNNIDSLEPL--APLRNLEQLDASNNQISD-LEELLDLLSSWPSLRELDL--------------------- 175

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 148664213 251 rllvlQGNPLALVPYYRGLTIDSLAQLCVLDDITVSPNEK 290
Cdd:cd21340  176 -----TGNPVCKKPKYRDKIILASKSLEVLDGKEITDTER 210
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
156-352 6.50e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.69  E-value: 6.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148664213 156 LSANRIKEVDA--TNLPpTLKVLELYGNEISSMECLCAHPpaGLQHLGLGHNKL--LGPLESLyvtanhwPNLVSLDLGF 231
Cdd:COG4886  212 LSGNQLTDLPEplANLT-NLETLDLSNNQLTDLPELGNLT--NLEELDLSNNQLtdLPPLANL-------TNLKTLDLSN 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148664213 232 NDLTDLQSMVTSLRTLRHLRLLVLQGNPLALVPYYRGLTIDSLAQLCVLDDITVSPNEKHLFRGLSLNGDLLAQEAQFVV 311
Cdd:COG4886  282 NQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSL 361

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 148664213 312 TIGNIRGVLDTSVLDPEPRPEGPFITYNYYVTYDFVKDEEG 352
Cdd:COG4886  362 LLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLL 402
LRR_8 pfam13855
Leucine rich repeat;
155-207 4.26e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 4.26e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 148664213  155 VLSANRIKEVDATNL--PPTLKVLELYGNEISSMECLCAHPPAGLQHLGLGHNKL 207
Cdd:pfam13855   7 DLSNNRLTSLDDGAFkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 171-290 7.95e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.55  E-value: 7.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148664213 171 PTLKVLELYGNEISSMECLcaHPPAGLQHLGLGHNKLLGpLESLYVTANHWPNLVSLDLgfndltdlqsmvtslrtlrhl 250
Cdd:cd21340  120 NSLRVLNISGNNIDSLEPL--APLRNLEQLDASNNQISD-LEELLDLLSSWPSLRELDL--------------------- 175

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 148664213 251 rllvlQGNPLALVPYYRGLTIDSLAQLCVLDDITVSPNEK 290
Cdd:cd21340  176 -----TGNPVCKKPKYRDKIILASKSLEVLDGKEITDTER 210
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 156-232 5.02e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.86  E-value: 5.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148664213 156 LSANRIKEVDATNLPPTLKVLELYGNEISSMECL--CAHppagLQHLGLGHNKL--LGPLESLyvtanhwPNLVSLDLGF 231
Cdd:cd21340    9 LNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLefLTN----LTHLYLQNNQIekIENLENL-------VNLKKLYLGG 77


                 .
gi 148664213 232 N 232
Cdd:cd21340   78 N 78
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
156-352 6.50e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.69  E-value: 6.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148664213 156 LSANRIKEVDA--TNLPpTLKVLELYGNEISSMECLCAHPpaGLQHLGLGHNKL--LGPLESLyvtanhwPNLVSLDLGF 231
Cdd:COG4886  212 LSGNQLTDLPEplANLT-NLETLDLSNNQLTDLPELGNLT--NLEELDLSNNQLtdLPPLANL-------TNLKTLDLSN 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148664213 232 NDLTDLQSMVTSLRTLRHLRLLVLQGNPLALVPYYRGLTIDSLAQLCVLDDITVSPNEKHLFRGLSLNGDLLAQEAQFVV 311
Cdd:COG4886  282 NQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSL 361

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 148664213 312 TIGNIRGVLDTSVLDPEPRPEGPFITYNYYVTYDFVKDEEG 352
Cdd:COG4886  362 LLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLL 402
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
156-237 5.70e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.61  E-value: 5.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148664213 156 LSANRIKEVDA--TNLPpTLKVLELYGNEISSMeclcahPPA-----GLQHLGLGHNKL------LGP---LESLYVTAN 219
Cdd:COG4886  120 LSGNQLTDLPEelANLT-NLKELDLSNNQLTDL------PEPlgnltNLKSLDLSNNQLtdlpeeLGNltnLKELDLSNN 192

                         90       100
                 ....*....|....*....|....*...
gi 148664213 220 H----------WPNLVSLDLGFNDLTDL 237
Cdd:COG4886  193 QitdlpeplgnLTNLEELDLSGNQLTDL 220
LRR_8 pfam13855
Leucine rich repeat;
155-207 4.26e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 4.26e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 148664213  155 VLSANRIKEVDATNL--PPTLKVLELYGNEISSMECLCAHPPAGLQHLGLGHNKL 207
Cdd:pfam13855   7 DLSNNRLTSLDDGAFkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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