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Conserved domains on  [gi|148728160|ref|NP_001091973|]
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receptor-type tyrosine-protein phosphatase eta isoform 2 precursor [Homo sapiens]

Protein Classification

FN3 domain-containing protein( domain architecture ID 11510106)

FN3 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 119-205 8.77e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 47.11  E-value: 8.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728160 119 PSPVFDIKAVSISPTNVILTWKSNDTAASEY-KYVVKHKMENEKTITVVH-----QPWCNITGLRPATSYVFSITpGIGN 192
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPItGYVVEYREKGSGDWKEVEvtpgsETSYTLTGLKPGTEYEFRVR-AVNG 79

                         90
                 ....*....|...
gi 148728160 193 ETWGDPRVIKVIT 205
Cdd:cd00063   80 GGESPPSESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 371-445 1.79e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.25  E-value: 1.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728160 371 DVTAVNISATSLTLIWKVSDNESSSNYTYKIHV--AGETDSSNLNV---SEPRAVIPGLRSSTFYNITVCPVLGDIEGTP 445
Cdd:cd00063    6 NLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYreKGSGDWKEVEVtpgSETSYTLTGLKPGTEYEFRVRAVNGGGESPP 85
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
182-531 1.35e-04

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 44.61  E-value: 1.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728160 182 YVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSWSNGNGTASCRVLLESIGSHEELTQDSRLQVNISG 261
Cdd:COG3401   42 VVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPA 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728160 262 LKPGVQYNINPYLLQSNKTKGDPLGTEGGLDASNTERSRAGS----PTAPVHDESLVGPVDPSSGQQSRDTEVLLVGLEP 337
Cdd:COG3401  122 VGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVagagVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEP 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728160 338 GTRYNATVYSQAANGTEGQPQAIEFRTNAIQ---VFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNL-N 413
Cdd:COG3401  202 GTTYYYRVAATDTGGESAPSNEVSVTTPTTPpsaPTGLTATADTPGSVTLSWDPVTESDATGYRVYRSNSGDGPFTKVaT 281

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728160 414 VSEPRAVIPGLRSSTFYNITVCPVLGD---------IEGTPGflqvHTPPVPVSDFRVTVVSTTEIGLAW---SSHDAES 481
Cdd:COG3401  282 VTTTSYTDTGLTNGTTYYYRVTAVDAAgnesapsnvVSVTTD----LTPPAAPSGLTATAVGSSSITLSWtasSDADVTG 357

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 148728160 482 FQMHITQEGAGNSRV--EITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGAS 531
Cdd:COG3401  358 YNVYRSTSGGGTYTKiaETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAP 409
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 119-205 8.77e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 47.11  E-value: 8.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728160 119 PSPVFDIKAVSISPTNVILTWKSNDTAASEY-KYVVKHKMENEKTITVVH-----QPWCNITGLRPATSYVFSITpGIGN 192
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPItGYVVEYREKGSGDWKEVEvtpgsETSYTLTGLKPGTEYEFRVR-AVNG 79

                         90
                 ....*....|...
gi 148728160 193 ETWGDPRVIKVIT 205
Cdd:cd00063   80 GGESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
120-187 3.54e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.10  E-value: 3.54e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148728160  120 SPVFDIKAVSISPTNVILTWKSNDTAASEY-KYVVKHKMENE----KTITVV-HQPWCNITGLRPATSYVFSIT 187
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPItGYEVEYRPKNSgepwNEITVPgTTTSVTLTGLKPGTEYEVRVQ 74
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 119-187 7.35e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.14  E-value: 7.35e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 148728160   119 PSPVFDIKAVSISPTNVILTWK-SNDTAASEY--KYVVKHKMENEKTITV---VHQPWCNITGLRPATSYVFSIT 187
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEpPPDDGITGYivGYRVEYREEGSEWKEVnvtPSSTSYTLTGLKPGTEYEFRVR 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 371-445 1.79e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.25  E-value: 1.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728160 371 DVTAVNISATSLTLIWKVSDNESSSNYTYKIHV--AGETDSSNLNV---SEPRAVIPGLRSSTFYNITVCPVLGDIEGTP 445
Cdd:cd00063    6 NLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYreKGSGDWKEVEVtpgSETSYTLTGLKPGTEYEFRVRAVNGGGESPP 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
182-531 1.35e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 44.61  E-value: 1.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728160 182 YVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSWSNGNGTASCRVLLESIGSHEELTQDSRLQVNISG 261
Cdd:COG3401   42 VVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPA 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728160 262 LKPGVQYNINPYLLQSNKTKGDPLGTEGGLDASNTERSRAGS----PTAPVHDESLVGPVDPSSGQQSRDTEVLLVGLEP 337
Cdd:COG3401  122 VGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVagagVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEP 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728160 338 GTRYNATVYSQAANGTEGQPQAIEFRTNAIQ---VFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNL-N 413
Cdd:COG3401  202 GTTYYYRVAATDTGGESAPSNEVSVTTPTTPpsaPTGLTATADTPGSVTLSWDPVTESDATGYRVYRSNSGDGPFTKVaT 281

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728160 414 VSEPRAVIPGLRSSTFYNITVCPVLGD---------IEGTPGflqvHTPPVPVSDFRVTVVSTTEIGLAW---SSHDAES 481
Cdd:COG3401  282 VTTTSYTDTGLTNGTTYYYRVTAVDAAgnesapsnvVSVTTD----LTPPAAPSGLTATAVGSSSITLSWtasSDADVTG 357

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 148728160 482 FQMHITQEGAGNSRV--EITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGAS 531
Cdd:COG3401  358 YNVYRSTSGGGTYTKiaETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAP 409
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 371-443 2.52e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.91  E-value: 2.52e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148728160   371 DVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSS-----NLNVSEPRAVIPGLRSSTFYNITVCPVLGDIEG 443
Cdd:smart00060   6 NLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSewkevNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
368-445 4.85e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 39.32  E-value: 4.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728160  368 QVFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNV-----SEPRAVIPGLRSSTFYNITVCPVLGDIE 442
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEitvpgTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                  ...
gi 148728160  443 GTP 445
Cdd:pfam00041  82 GPP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 454-526 1.21e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.98  E-value: 1.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728160   454 PVPVSDFRVTVVSTTEIGLAWSSHDAE-------SFQMHITQEGAGNSRVEITTNQ-SIIIGGLFPGTKYCFEIVPKGPN 525
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDgitgyivGYRVEYREEGSEWKEVNVTPSStSYTLTGLKPGTEYEFRVRAVNGA 80


                   .
gi 148728160   526 G 526
Cdd:smart00060  81 G 81
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 454-538 3.39e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.09  E-value: 3.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728160 454 PVPVSDFRVTVVSTTEIGLAWSS-----HDAESFQMHITQEGAGNSR---VEITTNQSIIIGGLFPGTKYCFEIVPKGPN 525
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPpeddgGPITGYVVEYREKGSGDWKeveVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                         90
                 ....*....|...
gi 148728160 526 GTEGASRTVCNRT 538
Cdd:cd00063   81 GESPPSESVTVTT 93
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 119-205 8.77e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 47.11  E-value: 8.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728160 119 PSPVFDIKAVSISPTNVILTWKSNDTAASEY-KYVVKHKMENEKTITVVH-----QPWCNITGLRPATSYVFSITpGIGN 192
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPItGYVVEYREKGSGDWKEVEvtpgsETSYTLTGLKPGTEYEFRVR-AVNG 79

                         90
                 ....*....|...
gi 148728160 193 ETWGDPRVIKVIT 205
Cdd:cd00063   80 GGESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
120-187 3.54e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.10  E-value: 3.54e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148728160  120 SPVFDIKAVSISPTNVILTWKSNDTAASEY-KYVVKHKMENE----KTITVV-HQPWCNITGLRPATSYVFSIT 187
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPItGYEVEYRPKNSgepwNEITVPgTTTSVTLTGLKPGTEYEVRVQ 74
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 119-187 7.35e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.14  E-value: 7.35e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 148728160   119 PSPVFDIKAVSISPTNVILTWK-SNDTAASEY--KYVVKHKMENEKTITV---VHQPWCNITGLRPATSYVFSIT 187
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEpPPDDGITGYivGYRVEYREEGSEWKEVnvtPSSTSYTLTGLKPGTEYEFRVR 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 371-445 1.79e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.25  E-value: 1.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728160 371 DVTAVNISATSLTLIWKVSDNESSSNYTYKIHV--AGETDSSNLNV---SEPRAVIPGLRSSTFYNITVCPVLGDIEGTP 445
Cdd:cd00063    6 NLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYreKGSGDWKEVEVtpgSETSYTLTGLKPGTEYEFRVRAVNGGGESPP 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
182-531 1.35e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 44.61  E-value: 1.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728160 182 YVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSWSNGNGTASCRVLLESIGSHEELTQDSRLQVNISG 261
Cdd:COG3401   42 VVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPA 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728160 262 LKPGVQYNINPYLLQSNKTKGDPLGTEGGLDASNTERSRAGS----PTAPVHDESLVGPVDPSSGQQSRDTEVLLVGLEP 337
Cdd:COG3401  122 VGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVagagVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEP 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728160 338 GTRYNATVYSQAANGTEGQPQAIEFRTNAIQ---VFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNL-N 413
Cdd:COG3401  202 GTTYYYRVAATDTGGESAPSNEVSVTTPTTPpsaPTGLTATADTPGSVTLSWDPVTESDATGYRVYRSNSGDGPFTKVaT 281

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728160 414 VSEPRAVIPGLRSSTFYNITVCPVLGD---------IEGTPGflqvHTPPVPVSDFRVTVVSTTEIGLAW---SSHDAES 481
Cdd:COG3401  282 VTTTSYTDTGLTNGTTYYYRVTAVDAAgnesapsnvVSVTTD----LTPPAAPSGLTATAVGSSSITLSWtasSDADVTG 357

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 148728160 482 FQMHITQEGAGNSRV--EITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGAS 531
Cdd:COG3401  358 YNVYRSTSGGGTYTKiaETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAP 409
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 371-443 2.52e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.91  E-value: 2.52e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148728160   371 DVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSS-----NLNVSEPRAVIPGLRSSTFYNITVCPVLGDIEG 443
Cdd:smart00060   6 NLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSewkevNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
368-445 4.85e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 39.32  E-value: 4.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728160  368 QVFDVTAVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNV-----SEPRAVIPGLRSSTFYNITVCPVLGDIE 442
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEitvpgTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81


                  ...
gi 148728160  443 GTP 445
Cdd:pfam00041  82 GPP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 454-526 1.21e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.98  E-value: 1.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728160   454 PVPVSDFRVTVVSTTEIGLAWSSHDAE-------SFQMHITQEGAGNSRVEITTNQ-SIIIGGLFPGTKYCFEIVPKGPN 525
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDgitgyivGYRVEYREEGSEWKEVNVTPSStSYTLTGLKPGTEYEFRVRAVNGA 80


                   .
gi 148728160   526 G 526
Cdd:smart00060  81 G 81
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 454-538 3.39e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.09  E-value: 3.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148728160 454 PVPVSDFRVTVVSTTEIGLAWSS-----HDAESFQMHITQEGAGNSR---VEITTNQSIIIGGLFPGTKYCFEIVPKGPN 525
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPpeddgGPITGYVVEYREKGSGDWKeveVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                         90
                 ....*....|...
gi 148728160 526 GTEGASRTVCNRT 538
Cdd:cd00063   81 GESPPSESVTVTT 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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