NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|147902954|ref|NP_001091017|]
View 

alpha-2,8-sialyltransferase 8B precursor [Canis lupus familiaris]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 54-325 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467715  Cd Length: 278  Bit Score: 601.54  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954  54 RKQILKFLDAEKDISVLKGTLKPGDIIHYIFDRDSTMNVSQNLYDLLPRTSPLKNKHFRTCAIVGNSGVLLNSGCGQEID 133
Cdd:cd23987    7 RKQILKFLDAERDISVLKGTLKPGDVIHYVFDRDSTMNISQNLYELLPRTSPLKNKHFKTCAIVGNSGILLNSGCGREID 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 134 THSFVIRCNLAPVQEYGRDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLRSLNGSILWIPAFMARGGKERVEWVN 213
Cdd:cd23987   87 SHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPSVVQRAFEDLVNETWKEKFLQRLQSLNGSILWIPAFMAKGGEERVEWVN 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 214 ELILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFPLDQNQNPVKYHYYDSLK 293
Cdd:cd23987  167 DLILKHHINVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQNPVKYHYYDSLK 246

                        250       260       270
                 ....*....|....*....|....*....|..
gi 147902954 294 YGYTSQASPHTMPLEFKALKSLHEQGALKLTV 325
Cdd:cd23987  247 YGYTSQASPHTMPLEFKALKNLHQQGALKLTV 278
 
Name Accession Description Interval E-value
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 54-325 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 601.54  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954  54 RKQILKFLDAEKDISVLKGTLKPGDIIHYIFDRDSTMNVSQNLYDLLPRTSPLKNKHFRTCAIVGNSGVLLNSGCGQEID 133
Cdd:cd23987    7 RKQILKFLDAERDISVLKGTLKPGDVIHYVFDRDSTMNISQNLYELLPRTSPLKNKHFKTCAIVGNSGILLNSGCGREID 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 134 THSFVIRCNLAPVQEYGRDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLRSLNGSILWIPAFMARGGKERVEWVN 213
Cdd:cd23987   87 SHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPSVVQRAFEDLVNETWKEKFLQRLQSLNGSILWIPAFMAKGGEERVEWVN 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 214 ELILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFPLDQNQNPVKYHYYDSLK 293
Cdd:cd23987  167 DLILKHHINVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQNPVKYHYYDSLK 246

                        250       260       270
                 ....*....|....*....|....*....|..
gi 147902954 294 YGYTSQASPHTMPLEFKALKSLHEQGALKLTV 325
Cdd:cd23987  247 YGYTSQASPHTMPLEFKALKNLHQQGALKLTV 278
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 68-320 4.43e-102

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 300.29  E-value: 4.43e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954   68 SVLKGTLKPGDIIHYiFDRDSTMNVSQNLYDLLPRTSPLKNKHFRTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQ 147
Cdd:pfam00777   1 FLTKENFPLGEWIRY-SEWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954  148 EYGRDVGLKTDLVTMNP-SVIQRAFEDLVNATWREKLLQRLRSLNG--SILWIPAFMARGGKERVEWVNELILKHHVNV- 223
Cdd:pfam00777  80 GYEKDVGSKTTLRTMNPeSAIDSKYGNLGFSHPRDPFVEFVLVPFKgrDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPVd 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954  224 --RTAYPSLRLLHAVRGYWL-TNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFpldQNQNPVKYHYYDSLKYGYTSQA 300
Cdd:pfam00777 160 pdKVLFLHPDFLRYVANFWLrSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPF---LDSRGNSHHYYDNVLMKKGGFY 236

                         250       260
                  ....*....|....*....|
gi 147902954  301 SPHTMPLEFKALKSLHEQGA 320
Cdd:pfam00777 237 GVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 54-325 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 601.54  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954  54 RKQILKFLDAEKDISVLKGTLKPGDIIHYIFDRDSTMNVSQNLYDLLPRTSPLKNKHFRTCAIVGNSGVLLNSGCGQEID 133
Cdd:cd23987    7 RKQILKFLDAERDISVLKGTLKPGDVIHYVFDRDSTMNISQNLYELLPRTSPLKNKHFKTCAIVGNSGILLNSGCGREID 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 134 THSFVIRCNLAPVQEYGRDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLRSLNGSILWIPAFMARGGKERVEWVN 213
Cdd:cd23987   87 SHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPSVVQRAFEDLVNETWKEKFLQRLQSLNGSILWIPAFMAKGGEERVEWVN 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 214 ELILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFPLDQNQNPVKYHYYDSLK 293
Cdd:cd23987  167 DLILKHHINVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQNPVKYHYYDSLK 246

                        250       260       270
                 ....*....|....*....|....*....|..
gi 147902954 294 YGYTSQASPHTMPLEFKALKSLHEQGALKLTV 325
Cdd:cd23987  247 YGYTSQASPHTMPLEFKALKNLHQQGALKLTV 278
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 54-325 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 509.65  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954  54 RKQILKFLDAEKDISVLKGTLKPGDIIHYIFDRDSTMNVSQNLYDLLPRTSPLKNKHFRTCAIVGNSGVLLNSGCGQEID 133
Cdd:cd23969    7 RKWILKFFDPEKDISVLKSQVKPGDRMHYEIDRHKTVNITQDLYQLLPEVSPLKGKHFRTCAVVGNSGILLNSGCGQEID 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 134 THSFVIRCNLAPVQEYGRDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLRSLNGSILWIPAFMARGGKERVEWVN 213
Cdd:cd23969   87 SHDFVIRCNLAPVEGYEKDVGTKSNLTTMNPSVIPHAYGDLVNATDKEKFVERLRQLGDSILWIPAFVSKGGEEHVQWTN 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 214 ELILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFPLDQNQNPVKYHYYDSLK 293
Cdd:cd23969  167 EIILKHKLNVKTAYPPLRLNHAIRGYWLTTKFRIKRPSTGLLMYTLATRFCDEIHLYGFYPFSEDGNGRAVKYHYYDNRK 246

                        250       260       270
                 ....*....|....*....|....*....|..
gi 147902954 294 YGYtsQASPHTMPLEFKALKSLHEQGALKLTV 325
Cdd:cd23969  247 YLT--TARPHKMPEEFRALRSLHQRGALRLHT 276
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 54-324 1.12e-173

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 482.53  E-value: 1.12e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954  54 RKQILKFLDAEKDISVLKGTLKPGDIIHYIFDRDSTMNVSQNLYDLLPRTSPLKNKHFRTCAIVGNSGVLLNSGCGQEID 133
Cdd:cd23988    7 RKDILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISQNLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSGCGKEID 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 134 THSFVIRCNLAPVQEYGRDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLRSLNGSILWIPAFMARGGKERVEWVN 213
Cdd:cd23988   87 SHDFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWVN 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 214 ELILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFPLDQNQNPVKYHYYDSLK 293
Cdd:cd23988  167 ALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVNIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDANGNPVKYHYYDDLK 246

                        250       260       270
                 ....*....|....*....|....*....|.
gi 147902954 294 YGYTSQASPHTMPLEFKALKSLHEQGALKLT 324
Cdd:cd23988  247 YRYFSNAGPHRMPLEFKTLNVLHNRGALKLT 277
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 54-325 1.68e-111

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 324.98  E-value: 1.68e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954  54 RKQILKFLDAEKDISVLKGTlKPGDIIHYIFDRDSTMNVSQNLYDLLPRTSPLKNKHFRTCAIVGNSGVLLNSGCGQEID 133
Cdd:cd23963    7 RKELERLLNTRKLFLTQKNT-PLGDVLYYSYFKKKTFKITKSLYELLPKTSPFSHKRYKTCAVVGNSGILLGSGCGKEID 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 134 THSFVIRCNLAPVQEYGRDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLRSLNGSILWIPAFMARGGKERVEWVN 213
Cdd:cd23963   86 SHDFVIRCNLPPIKGFEKDVGRKTNLTTLNPSILKRRYNSLKKNRDRDKFLNRLKEYNGSILWYPKFSFKSSTNLLLKAA 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 214 ELILKHHVNVRTAYPSLRLLHAVRGYWLTNKVhIKRPTTGLLMYTLATRFCNQIYLYGFWPFPLDQNQNPVKYHYYDSLK 293
Cdd:cd23963  166 RALKKNGLNLTVVYSNPEHFLAVQKFWKRRGL-EKRPSTGLYLVSLALTFCDEIHLYGFWPFPTDPNGRPVPYHYYDDLS 244

                        250       260       270
                 ....*....|....*....|....*....|..
gi 147902954 294 YGYTSqaSPHTMPLEFKALKSLHEQGALKLTV 325
Cdd:cd23963  245 PSTKN--KVHNMPEEFKLLRELHKKGVLKLHT 274
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 68-320 4.43e-102

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 300.29  E-value: 4.43e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954   68 SVLKGTLKPGDIIHYiFDRDSTMNVSQNLYDLLPRTSPLKNKHFRTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQ 147
Cdd:pfam00777   1 FLTKENFPLGEWIRY-SEWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954  148 EYGRDVGLKTDLVTMNP-SVIQRAFEDLVNATWREKLLQRLRSLNG--SILWIPAFMARGGKERVEWVNELILKHHVNV- 223
Cdd:pfam00777  80 GYEKDVGSKTTLRTMNPeSAIDSKYGNLGFSHPRDPFVEFVLVPFKgrDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPVd 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954  224 --RTAYPSLRLLHAVRGYWL-TNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFpldQNQNPVKYHYYDSLKYGYTSQA 300
Cdd:pfam00777 160 pdKVLFLHPDFLRYVANFWLrSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPF---LDSRGNSHHYYDNVLMKKGGFY 236

                         250       260
                  ....*....|....*....|
gi 147902954  301 SPHTMPLEFKALKSLHEQGA 320
Cdd:pfam00777 237 GVHDMPFEFKLLQKLHKEGV 256
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 54-325 1.27e-96

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 287.37  E-value: 1.27e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954  54 RKQILKFLDAEKDISVLKGTLKPGDIIHYIFDRDSTMN-VSQNLYDLLPRTSPLKNKHFRTCAIVGNSGVLLNSGCGQEI 132
Cdd:cd23970   10 RKEIRQYFDVIKNISLTKKDVRIGQLMHFDYSSHKYVFsISPNLRSLLPEVSPFQNKHYNTCAVVGNSGILTNSQCGNEI 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 133 DTHSFVIRCNLAPVQEYGRDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLLQRLRSLNGSILWIPAFMARGGKERVEWV 212
Cdd:cd23970   90 DKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNPSILEKYYNNLLTIQDRNNFFLSLKKLDGAILWIPAFFFHTSATVTRTL 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 213 NELILKH--HVNVRTAYPSlRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFPLDQNQNPVKYHYYD 290
Cdd:cd23970  170 VDFFVEHrgQLKVQLAWPG-NIMQHVNRYWKTKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPTGTPLPYHYYD 248

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 147902954 291 SL--KYGYTSQASpHTMPLEFKALKSLHEQGALKLTV 325
Cdd:cd23970  249 KKgtKFTTKWQES-HQLPAEFVLLYKMHGAGVLKLTL 284
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 77-323 4.79e-71

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 221.75  E-value: 4.79e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954  77 GDIIHYIFDRDSTMNVSQNLYDLLPRTSPLKNKHFRTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVqEYGRDVGLK 156
Cdd:cd23971   30 GSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPPL-NDSKDVGSK 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 157 TDLVTMNPSVIQRAFEDLVNatWREKLLQRLRSLNGSILWIPAFMARGGKE---RVEWVNELIlKHHVNVRTAYPS-LRL 232
Cdd:cd23971  109 TNLVTANPSILREKFHNLKK--RRRPFVERMKVYGNALLLLPAFSYTSNTEpslRALYTLEDF-GSPQKVLFFNPEyLRN 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 233 LHAvrgYWLTNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFPLDQNQNPVKYHYYDSLKygytSQASPHTMPLEFKAL 312
Cdd:cd23971  186 LSR---YWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDLDGNPISHHYYDNVL----PKKGVHAMPEEFLRY 258

                        250
                 ....*....|.
gi 147902954 313 KSLHEQGALKL 323
Cdd:cd23971  259 LKLHSQGVLRL 269
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 54-325 5.66e-60

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 193.51  E-value: 5.66e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954  54 RKQILKFLDAEKDISVLKGTLKPGDIIHYIFDRDSTMNVSQNLYDLLPRTSPLKnKHFRTCAIVGNSGVLLNSGCGQEID 133
Cdd:cd23989    7 RKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQ-LPLKKCSVVGNGGILKNSGCGQQID 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 134 THSFVIRCNLAPV-QEYGRDVGLKTDLVTMNPSVIQRAFEDLVnatW-REKLLQRLRSLNGSILWIPAFMARGGKERVEW 211
Cdd:cd23989   86 RADFVMRCNLPPLsREYTDDVGTKTQLVTANPSIIDKRFQNLL---WsRKSFVESMKVYGRSYIYMPAFSMKTGTDPSLR 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 212 VNELILKHHVNVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFPLDQNQNPVKYHYYDS 291
Cdd:cd23989  163 VYYTLADVGANQTVLFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERTISHHYYDN 242

                        250       260       270
                 ....*....|....*....|....*....|....
gi 147902954 292 LkygyTSQASPHTMPLEFKALKSLHEQGALKLTV 325
Cdd:cd23989  243 V----LPDSGFHAMPEEFLQLWHLHKSGVLRMQL 272
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 77-323 3.19e-51

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 170.79  E-value: 3.19e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954  77 GDIIHYIFDRDSTMNVSQNLYDLLPRTSPLKNKHFRTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPV-QEYGRDVGL 155
Cdd:cd23990   30 GTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPIsEKYVRDVGV 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 156 KTDLVTMNPSVIQRAFEDLvnATWREKLLQRLRSLNGSILWIPAFMARGGKE---RVEWVNElILKHHVNVRTAYPslRL 232
Cdd:cd23990  110 KTDVVTINPSIITERFHKL--EKWRRPFYEVLQVYENASVVLPAFYNTRNTDvsiRVKYVLD-DFESQQAVYYFHP--QY 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 233 LHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFPLDQNQNPVKYHYYDSLKygytSQASPHTMPLEFKAL 312
Cdd:cd23990  185 LLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITHHYYDNVK----PRPGFHAMPSEIFNF 260

                        250
                 ....*....|.
gi 147902954 313 KSLHEQGALKL 323
Cdd:cd23990  261 LHMHSRGILRV 271
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 89-323 2.82e-50

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 168.39  E-value: 2.82e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954  89 TMNVSQNLYDLLPRTSPLKNKHFRTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQ-EYGRDVGLKTDLVTMNPSVI 167
Cdd:cd23991   42 KILITENIFRMFPKSQPFRGYPYKQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGgNISKDVGSKTNLVTANPSII 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 168 QRAFEDLVNAtwREKLLQRLRSLNGSILWIPAFMAR----------------GGKERVEWVNELILKHhvnvrtaypslr 231
Cdd:cd23991  122 SIKYAKLNER--RKPFLETVSVYGDAFLLLPAFSYRsntalsfkvyytledfKAKQKVIFFHPIYLKH------------ 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 232 LLHavrgYWLTNKVHIKRPTTGLLMYTLATRFCNQIYLYGFWPFPLDQNQNPVKYHYYDSL--KYGYtsqaspHTMPLEF 309
Cdd:cd23991  188 LAQ----FWRSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFSKNTEGKPISHHYYDNQlpKPGF------HSMPKEF 257

                        250
                 ....*....|....
gi 147902954 310 KALKSLHEQGALKL 323
Cdd:cd23991  258 YQLLQLHSKGILKL 271
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 114-315 4.04e-36

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 129.02  E-value: 4.04e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 114 CAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLVTMNPSVIQRAFEDLVNATWREKLlqrlrsLNGS 193
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYLRGPRCGCHPLPL------EEEV 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 194 ILWIPAFMARGGKERV-----EWVNELILKHHVNvrtaypslRLLHAVRGYW----LTNKVHIKRPTTGLLMYTLATRFC 264
Cdd:cd19952   75 VLILSRAAAADFKRLKrrkkrHDNAVLLLTDPAP--------DLLSYVRKRLeklgLKSFFGGNAPSSGLLAVLLALQLC 146

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 147902954 265 NQIYLYGFWPFPLDQNQNPvkYHYYDslKYGYTSQASPHTMPLEFKALKSL 315
Cdd:cd19952  147 DSVDLYGFGVDSGHAPKVP--YHYYD--LVEAEEGTAVHSFDLEAELLRAL 193
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 113-323 8.73e-25

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 101.57  E-value: 8.73e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 113 TCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLVTMNP-SVIQRAFEDLV---NATW-----REKL 183
Cdd:cd23964   84 RCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPeSLHNSLLKHVPqdkDTKYlfipfKIRD 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 184 LQRLRS-LNGSIlwIPAFMARGGKERvewvneLILKHHVNVRTaypsLRLLHA-----VRGYWLtNKVHIKRPTTGLLMY 257
Cdd:cd23964  164 YDYLDAvLSGKP--VPDGCDKGKRPP------PLFGPKLNATN----VRLLHPdfiryLFNRWL-NSSTSYRPTTGALML 230

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 147902954 258 TLATRFCNQIYLYGF---WPFPLdqnqnpvkyHYYDSLKYGYTSQASPHTMPLEFKALKSLHEQGALKL 323
Cdd:cd23964  231 LTALHTCDQVSVYGFgydPRFSL---------HYYDKTFVKFTVFYANHDFTNERKLWRKLHEEGIINL 290
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 82-293 1.16e-24

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 100.42  E-value: 1.16e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954  82 YIFDRDST-MNVSQNLYDLLPRTSPLKNKHFRTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLV 160
Cdd:cd23968   15 STLRKTTSpFKDLLSLRYPFPESSLENTKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLR 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 161 TMNpSVI----QRAFEDlvnatwreKLLQRlrslNGSIL-WIPAFMARGGKERVEWVNELILKHHVNVRTAYPSLRL-LH 234
Cdd:cd23968   95 LIN-SQIlskpEFNFLT--------DPLYR----NVTLLvWDPSSYNVNLEKWYKKPDFDFFPNYIKYRRRHPEEPFyLI 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 147902954 235 AVRGYW-------LTNKVHIKR--PTTGLLMYTLATRFCNQIYLYGFWPfPLDQNQnpvKYHYYDSLK 293
Cdd:cd23968  162 DPRFLWrlwdilqEYTPEKIKPnpPSSGFIGIVLMLHLCDWVDVYEYVP-SVRQTD---RCHYYDVEK 225
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 91-323 2.29e-20

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 88.88  E-value: 2.29e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954  91 NVSQNLYDLLPRTSPLKNK---HFRTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLVTMNP--S 165
Cdd:cd23966   54 EVLEKLFQVVPGENPYRTRdpnRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPesA 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 166 VIQRAFEDLVNATWREKLLQRLRSL--NGSILW----IPAFMaRGGKERVEWVNelilkhhvnvrtayPSlrLLHAVRGY 239
Cdd:cd23966  134 VDLDPGVHLVLVPFKVLDLQWLISAltTGEITRtytpVKRFI-KADKDKVLVIN--------------PA--FIKYVHDN 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 240 WLTNkvHIKRPTTGLLMYTLATRFCNQIYLYGFWPfplDQNQNpvKYHYYDSLKY-GYTSQASPHTMPLEFKALKSLHEQ 318
Cdd:cd23966  197 WTEH--HGRYPSTGFLALIFALHICDEVSVFGFGA---DSKGN--WHHYWEKNRSaGAFRKTGVHDADFESDIIKKLAKE 269


                 ....*
gi 147902954 319 GALKL 323
Cdd:cd23966  270 GKIRV 274
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 105-292 4.19e-20

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 87.62  E-value: 4.19e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 105 PLKnKHFRTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLVTMNPSVIQRAfedlvnatwrekLL 184
Cdd:cd23976   10 PLK-MHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRI------------LR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 185 QRLRSLNGS-----ILWIPA-FMARGGKERVewVNELILKHHVnvrtaYPSLRLLHAVRGYWLTNKVHIKRPT------- 251
Cdd:cd23976   77 NRNELLNVSqgtvfIFWGPSnYMRRDGKGLV--YNNLQLMNQI-----LPKLKVYTITRHKMLQFDELFKRETgkdrkis 149

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 147902954 252 -----TGLLMYTLATRFCNQIYLYGFWP--FPLDQNQNPVKYHYYDSL 292
Cdd:cd23976  150 ntwlsTGWFTMIIALELCDRINVYGMVPpdFCRDPNHPSVPYHYYEPS 197
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 112-315 5.22e-20

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 86.58  E-value: 5.22e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 112 RTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLVTMNP-SVIQRAFEDLVNAT------------ 178
Cdd:cd23967    3 RRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPeSAFRDPEEYDSDWLlvlvpfksmdll 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 179 WREKLLQRlRSLNGSILWI--PAFMARGGKERVEWVNELILKhhvnvRTAYPSLRLLHAvrgywltNKVHIKRPTTGLLM 256
Cdd:cd23967   83 WLQAVIKG-KKPNGKGGFWkkIATSVPKPPKKIRILNPYILQ-----EAAFDLIGLPMN-------GKQGKNVPTTGIIA 149

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 147902954 257 YTLATRFCNQIYLYGFwPFPLDQNQNPvkYHYYDSLKYGYTSQASPHTMPLEFKALKSL 315
Cdd:cd23967  150 IVMALHYCDEVDIAGF-GYDPSDPNAP--LHYYDSLTMKAIKRSWTHNVTKEKKYLKKL 205
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 112-315 7.55e-20

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 85.87  E-value: 7.55e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 112 RTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLVTMNPsviQRAFEDLVNATWREKLLQRLRSLN 191
Cdd:cd23982    3 RRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYP---ESAQFDPGIENDPDTLLVLVPFKP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 192 GSILWIPAFMARGGKERVEWVNELILKHHVN---VRTAYP------SLRLLHaVRGywltNKVHIKRPTTGLLMYTLATR 262
Cdd:cd23982   80 LDFYWLYEILSNEKRVRKGFWKQPPRIWDANpkqIRILNPyytyvaATKLLQ-VPG----QRKKKQKPTTGLLAITLALH 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 147902954 263 FCNQIYLYGFwPFPLDQNQN-PVkyHYYDslkyGYTS---QASPHTMPLEFKALKSL 315
Cdd:cd23982  155 LCDEVHIAGF-GYPDNGNSNqPI--HYYN----QITLksmANSGHNLNAEAQAIQRL 204
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 109-291 3.66e-16

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 77.05  E-value: 3.66e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 109 KHFRTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLVTMNPSVI---QRAFedLVNATWREKLLq 185
Cdd:cd23985   43 GPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLINSQLVtteKHKF--LKDSLYNEGIL- 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 186 rlrslngsILWIPAFMArggKERVEWVNelilKHHVNVRTAYPSLRLLHAVRGYWLTNKV---------------HIKR- 249
Cdd:cd23985  120 --------IVWDPAPYH---SDIPEWYK----NPDYNFFENYKTYRRLNPNQPFYILHPQmqwelwdiiqenspeEIQPn 184

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 147902954 250 -PTTGLLMYTLATRFCNQIYLYGFWPfplDQNQNPVkYHYYDS 291
Cdd:cd23985  185 pPSSGMLGIILMMTLCDQVDVYEFLP---SKRKTDV-CHYYQK 223
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 112-294 1.42e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 74.59  E-value: 1.42e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 112 RTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLVTMNPSVIQRAFEDlvnatwREKLLQRLRSLN 191
Cdd:cd23965    2 DTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVSHSSLPRLLRN------AILLLAGTRAPT 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 192 GSILWIPAF-MARGGKERVEWVNELILKH-HVNVRTAYPSlRLLHAVR-------------GYWLtnkvhikrpTTGLLM 256
Cdd:cd23965   76 VVVFWGPETkMNKDGAGKYNLLRSLSKKYpDVEFYSLTPE-KMDYADElfeketgksriksGTWL---------STGWFT 145

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 147902954 257 YTLATRFCNQIYLYGFWP------FPLDQnqnpVKYHYYDSLKY 294
Cdd:cd23965  146 MLLALDVCDEIKVYGMVPenycreHPNSK----VPYHYYEPGGL 185
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 84-323 7.93e-15

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 73.37  E-value: 7.93e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954  84 FDRDSTMNVSQNLYDLLPRTSPLKNK---HFRTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLV 160
Cdd:cd23979   50 FKPHNTKEVLSKLFQIIPGENPYRSWdpsRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHH 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 161 TMNPsviQRAFEDLVNATWrekLLQRLRSLNgsILWIPAFMARG---------------GKERVEWVNELILKHhvnvrt 225
Cdd:cd23979  130 FMYP---ESAKNLPANVSF---VLVPFKTLD--LLWITSALSTGqirftyapvkqflrvDKDKVQIYNPAFFKY------ 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 226 aypslrllhaVRGYWLTNkvHIKRPTTGLLMYTLATRFCNQIYLYGFWPfplDQNQNpvKYHYYDSLKY-GYTSQASPHT 304
Cdd:cd23979  196 ----------IHDRWTEH--HGRYPSTGMLVLFFALHVCDEVNVYGFGA---DSRGN--WHHYWENNRYaGEFRKTGVHD 258

                        250
                 ....*....|....*....
gi 147902954 305 MPLEFKALKSLHEQGALKL 323
Cdd:cd23979  259 ADFEAHIIDMLAKAGKIKV 277
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 112-315 1.48e-14

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 71.32  E-value: 1.48e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 112 RTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDL--------------VTMNPSVIQRAF--EDLv 175
Cdd:cd23984    3 KKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFrlcypesifsdpshYDPNTTVVLIPFkpHDL- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 176 naTWREKLLQRlRSLNGSILW-IPAFMARGGKERVEWVNELILKhhvnvRTAYpslRLLHAVRGYWLTNKVhiKRPTTGL 254
Cdd:cd23984   82 --RWLLDLLMG-KKVSAKGFWkKPALNLIYKPNQIRILNPFILR-----IAAY---ELLHFPKRFPKEKKP--KHPTTGI 148

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 147902954 255 LMYTLATRFCNQIYLYGFwPFPLDQNQNPVkyHYYDSLKYGYTSQASPHTMPLEFKALKSL 315
Cdd:cd23984  149 IAITLALHICNEVHIAGF-KYDFSNLNSTL--HYYGNETMSVMTKNEYHNISAEQKFLKDL 206
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 110-315 1.33e-13

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 68.61  E-value: 1.33e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 110 HFRTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLvTMN-----PSVIQRAFEDLVNAT------ 178
Cdd:cd23983    1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTI-RMTypegaPKSEQEYDPTSLFVAvlfksv 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 179 ---WREKLLQRLRSLNGSILW--------IPAfmargGKERVEWVNELILKHHVNVRTAYPSLRllhavRGYWLTNKVHi 247
Cdd:cd23983   80 dfaWLKAMVKKEPLSFWSRLFfwkevadsIPL-----KPSQFRILNPLIIKETALDILQYPEPQ-----SRLWGWDKNV- 148

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 147902954 248 krPTTGLLMYTLATRFCNQIYLYGfwpFPLDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFKALKSL 315
Cdd:cd23983  149 --PTLGVTAVVLATHLCDEVSLAG---FGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 114-323 1.35e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 70.24  E-value: 1.35e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 114 CAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLV-----TMNPSVIqrAFEDL-VNATWREKLLQ-- 185
Cdd:cd23972   85 CAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTSFYgftvnTMKNSLI--SYWNLgFTRTPQGQDLQyi 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 186 ----RLRS---LNGSILWIPafMARGGKERVEWVNELILKHHVN-VRTAYPSlrLLHAVRGYWLTNKV------HIKRPT 251
Cdd:cd23972  163 fipsDIRDyvmLRSAILGVP--VPEGLDKGDRPHKYFGPEASAKkFKLLHPD--FISYLTDRFLKSKLlnthygHLYMPS 238

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 147902954 252 TGLLMYTLATRFCNQIYLYGFwpfpLDQNQNPVKYHYYDSLKYGYTSQASpHTMPLEFKALKSLHEQGALKL 323
Cdd:cd23972  239 TGALMLLTALHTCDQVSAYGF----ITSNYWKFSDHYYERKKKPLVFYAN-HDMLLEAALWRRLHKAGILQL 305
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 112-315 1.54e-13

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 68.41  E-value: 1.54e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 112 RTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLvtmnpsviqrafedlvNATWREKLLQRLRSLN 191
Cdd:cd23981    3 RRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTL----------------RITYPEGAIQKPEQYE 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 192 GSILWIPAfmarGGK-ERVEWVNELILKHHVN--------VRTAYP----SLRLLHAvrgYWL-----------TNKVHI 247
Cdd:cd23981   67 KDSLFVLA----GFKwQDFKWLKYIVYKEKVSasdgfwksVATRVPrephEIRILNP---YFIqeaafsfiglpFNNGLM 139

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 147902954 248 KR---PTTGLLMYTLATRFCNQIYLYGfwpFPLDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFKALKSL 315
Cdd:cd23981  140 GRgniPTLGSVAITMALHNCDEVAVAG---FGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLRKL 207
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 88-323 3.12e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 69.01  E-value: 3.12e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954  88 STMNVSQNLYDLLPRTSPLKNKHFRTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLVT------ 161
Cdd:cd23974   61 NLLNSSANGQMFDWWDRPNGRSPCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTfstntl 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 162 MN------------PSVIQRAFEDLVNATWREKLLQRLRSLNGSIlwipafmARG---GKERVEWVNELILKHHVNVR-- 224
Cdd:cd23974  141 MNslrayagvgfngPPQSKETRYIFLPDHDRDYLLVKAALTHTPI-------DRGrdkSKRPSKYFGKDVTAEKFKIYhp 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 225 --TAYPSLRLLHAvrGYWLTNKVHIKRPTTGLLMYTLATRFCNQIYLYGFwpfpLDQNQNPVKYHYYDSlKYGYTSQASP 302
Cdd:cd23974  214 dfIRYLRNRFLWS--PILNTKQRDIYRPSTGAVMLLAALHTCDQVSAYGF----MTPDYGKYSDHYYDK-TYHKVVFYAN 286

                        250       260
                 ....*....|....*....|.
gi 147902954 303 HTMPLEFKALKSLHEQGALKL 323
Cdd:cd23974  287 HDLRLEMQLWQKLHKAGLIKL 307
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 113-323 4.34e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 68.62  E-value: 4.34e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 113 TCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTdlvtmnpSVIQRAFEDLVNATW--REKLLQRLRSL 190
Cdd:cd23973   85 RCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRT-------SFYVHTAHSITSSLMilQKRGFKNIPQD 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 191 NGsilwIPAFMARGGKERVEWVNELILKHHVN---VRTAYP-----------SLRLLHA-----VRGYWLTNKV------ 245
Cdd:cd23973  158 KD----IKYILFPEGPRDYQWLEALLKNKTIPsgaYYGRRPrsyfsgdftedKYLVLHPdflryVKNRFLRSKTlkgkyw 233

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 246 HIKRPTTGLLMYTLATRFCNQIYLYGFwpfpldQNQNPVKY--HYYDsLKYGYTSQASPHTMPLEFKALKSLHEQGALKL 323
Cdd:cd23973  234 AIYRPTTGAFLLLTALHLCDTVSAYGF------ITEDYRKYpdHYYD-KKKTKLVFYINHDFRLEKKLWKRLHDEKIIKL 306
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 112-272 7.44e-13

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 67.60  E-value: 7.44e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 112 RTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKtdlvTMNPSVIQRAFEDLVNATwrEKLLQRLRSLN 191
Cdd:cd23980   82 RRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSK----TTHHFVYPESFRELAQNV--SMILVPFKTLD 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 192 gsILWIPAFMARG----------GKERVEwvNELILKHHvnvrtayPSlrLLHAVRGYWLTNkvHIKRPTTGLLMYTLAT 261
Cdd:cd23980  156 --LEWVISATTTGtishtyvpvpRKIKVK--KEKILIYH-------PA--FIKYVFDRWLQG--HGRYPSTGILSVIFSL 220

                        170
                 ....*....|.
gi 147902954 262 RFCNQIYLYGF 272
Cdd:cd23980  221 HVCDEVDLYGF 231
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 104-291 1.04e-12

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 67.17  E-value: 1.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 104 SPLKNKHFRTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLVTMNPSVIQRAFEDLV-NATWREK 182
Cdd:cd23986   42 SKLHLRGFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQILTNPNHHFIdSSLYKDV 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 183 LLqrlrslngsILWIPAFMARGGKERVEWVNELILKHHVNVRTAYPS--LRLLHAvRGYW---------LTNKVHIKRPT 251
Cdd:cd23986  122 IL---------VAWDPAPYSANLHKWYKKPDYNLFTPYVQYRKRNPNqpFYILHP-KFIWqlwdiiqenTQEKIQPNPPS 191

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 147902954 252 TGLLMYTLATRFCNQIYLYGFwpFPLDQNQNPVKYH--YYDS 291
Cdd:cd23986  192 SGFIGILIMMSMCREVHVYEY--IPSVRQTDLCHYHerYYDA 231
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 114-290 2.33e-09

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 56.79  E-value: 2.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 114 CAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDLVTMNPSVIQRAFEdlvnatwREKLLQRLRSLNGS 193
Cdd:cd23978    4 CALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVYRVLR-------RPQEFLNRTPETTL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 194 ILW-IPAFMARGGKERVEWVNELILKHHVNVRTAYPSLR-------LLHAVRG-------YWLtnkvhikrpTTGLLMYT 258
Cdd:cd23978   77 IFWgPPNKMQKDGKSNLFRIIQRASMTFPNMSAFVVSPRrmrqfddLFRGETGrdrkkshSWL---------STGWFTMV 147

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 147902954 259 LATRFCNQIYLYGFWPFP-LDQNQNPVK--YHYYD 290
Cdd:cd23978  148 IAVELCDNVHVYGMVPPNyCSKRPTPKKmpYHYYE 182
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 112-293 9.40e-09

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 54.87  E-value: 9.40e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 112 RTCAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDL-VTMNPSVIQRafedLVNATWrekLLQRLRSl 190
Cdd:cd23977    2 RRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLrVVSHTSVPLL----LRNQGY---FFQQSRD- 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902954 191 NGSILWIPA-FMARGGKERVewvnelilkHHVNVRTA--YPSLRLLHAVRGYWL---------TNKVHIKRPT---TGLL 255
Cdd:cd23977   74 TKYVIWGPErNMDRDGGGKT---------YRALLTLAkmYPHLQVYTLTEEKMAycdgvfqneTGKNRMKSGSflsTGWF 144

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 147902954 256 MYTLATRFCNQIYLYGFW--PFPLDQNQNPVKYHYYDSLK 293
Cdd:cd23977  145 TMILALELCEEILVYGMVsdSYCRNKNHSSVPYHYYEKGR 184
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 114-159 3.00e-06

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 47.62  E-value: 3.00e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 147902954 114 CAIVGNSGVLLNSGCGQEIDTHSFVIRCNLAPVQEYGRDVGLKTDL 159
Cdd:cd23975    4 CAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTI 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH