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Conserved domains on  [gi|148231601|ref|NP_001090487|]
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NGG1 interacting factor 3 like 1 S homeolog [Xenopus laevis]

Protein Classification

Nif3-like dinuclear metal center hexameric protein( domain architecture ID 10484881)

Nif3-like dinuclear metal center hexameric protein similar to Streptomyces coelicolor GTP cyclohydrolase 1 type 2 homolog and Homo sapiens NIF3-like protein 1

CATH:  3.40.1390.30

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
NIF3 pfam01784
NIF3 (NGG1p interacting factor 3); This family contains several NIF3 (NGG1p interacting factor ...
6-323 1.41e-69

NIF3 (NGG1p interacting factor 3); This family contains several NIF3 (NGG1p interacting factor 3) protein homologs. NIF3 interacts with the yeast transcriptional coactivator NGG1p which is part of the ADA complex, the exact function of this interaction is unknown.


:

Pssm-ID: 426431  Cd Length: 236  Bit Score: 217.10  E-value: 1.41e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231601    6 VVSHLNALTPPALAEGWDNVGLLVEpSPPHQVHKLLLTNDLTEDVLDEAINMEANMILSYHPPVFKALKRVTQKNWKERL 85
Cdd:pfam01784   2 IIELLEEIAPPELAEDWDNVGLQVG-DPENEVTKILVALDATEEVIEEAIENGADLIITHHPLIFRPLKSLTGDDPKGRR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231601   86 VVKALEKRLAIYSPHTSCDALANGVNDWLARALGPSKSVPLhastsltypggfghllefrldtaenifsrlksiqgvsvc 165
Cdd:pfam01784  81 IKKLIKNNISLYSAHTNLDAAPGGVNDWLAELLGLESIEPL--------------------------------------- 121
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231601  166 tstaspegqnvslscsqnalvealailseephvynslqllslqKPPLVDTGMGRLCTLAEPVSIAAAVERIKKHLHLPHL 245
Cdd:pfam01784 122 -------------------------------------------EPTEEGEGLGRIGELPEPMSLEELAAKVKEKLGLEGV 158
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231601  246 RLALGsgktLESSVRVAAVCAGSGSSILGGI---PADLYLTGEMSHHDVLDAVAEGRSVVLCEHSNSERGYLQELGGQIH 322
Cdd:pfam01784 159 RVVGD----LDKPIKKVAICGGSGSSLIDEAkakGADVLITGDVKYHDALDAQEKGINLIDAGHYATERFGLEALAELLK 234

                  .
gi 148231601  323 Q 323
Cdd:pfam01784 235 E 235
 
Name Accession Description Interval E-value
NIF3 pfam01784
NIF3 (NGG1p interacting factor 3); This family contains several NIF3 (NGG1p interacting factor ...
6-323 1.41e-69

NIF3 (NGG1p interacting factor 3); This family contains several NIF3 (NGG1p interacting factor 3) protein homologs. NIF3 interacts with the yeast transcriptional coactivator NGG1p which is part of the ADA complex, the exact function of this interaction is unknown.


Pssm-ID: 426431  Cd Length: 236  Bit Score: 217.10  E-value: 1.41e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231601    6 VVSHLNALTPPALAEGWDNVGLLVEpSPPHQVHKLLLTNDLTEDVLDEAINMEANMILSYHPPVFKALKRVTQKNWKERL 85
Cdd:pfam01784   2 IIELLEEIAPPELAEDWDNVGLQVG-DPENEVTKILVALDATEEVIEEAIENGADLIITHHPLIFRPLKSLTGDDPKGRR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231601   86 VVKALEKRLAIYSPHTSCDALANGVNDWLARALGPSKSVPLhastsltypggfghllefrldtaenifsrlksiqgvsvc 165
Cdd:pfam01784  81 IKKLIKNNISLYSAHTNLDAAPGGVNDWLAELLGLESIEPL--------------------------------------- 121
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231601  166 tstaspegqnvslscsqnalvealailseephvynslqllslqKPPLVDTGMGRLCTLAEPVSIAAAVERIKKHLHLPHL 245
Cdd:pfam01784 122 -------------------------------------------EPTEEGEGLGRIGELPEPMSLEELAAKVKEKLGLEGV 158
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231601  246 RLALGsgktLESSVRVAAVCAGSGSSILGGI---PADLYLTGEMSHHDVLDAVAEGRSVVLCEHSNSERGYLQELGGQIH 322
Cdd:pfam01784 159 RVVGD----LDKPIKKVAICGGSGSSLIDEAkakGADVLITGDVKYHDALDAQEKGINLIDAGHYATERFGLEALAELLK 234

                  .
gi 148231601  323 Q 323
Cdd:pfam01784 235 E 235
NIF3 COG0327
Putative GTP cyclohydrolase 1 type 2, NIF3 family [Coenzyme transport and metabolism]; ...
1-340 9.12e-52

Putative GTP cyclohydrolase 1 type 2, NIF3 family [Coenzyme transport and metabolism]; Putative GTP cyclohydrolase 1 type 2, NIF3 family is part of the Pathway/BioSystem: Folate biosynthesis


Pssm-ID: 440096  Cd Length: 254  Bit Score: 171.87  E-value: 9.12e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231601   1 MDLGSVVSHLNALTPPALAEGWDNVGLLV-EPSPPhqVHKLLLTNDLTEDVLDEAINMEANMILSYHPPVFKALKRVTQK 79
Cdd:COG0327    1 MTLSELVAALEELLPPALAESWDPNGLQVgEGRAE--VTRIVTAVDATQAVIEEAIEAGADLLIVHHPLFWKGEDSITAG 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231601  80 NWKERLVVKALEKRLAIYSPHTSCDA-LANGVNDWLARALGpsksvplhastsLTYPGGFGhllefrldtaenifsrlks 158
Cdd:COG0327   79 TVKGRRLALLIKNDIALYAAHTPLDAhPELGNNAQLARLLG------------LEDVEPLG------------------- 127
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231601 159 iqgvsvctstaspegqnvslscsqnalvealailseephvynslqllslqkpPLVDTGMGRLCTLAEPVSIAAAVERIKK 238
Cdd:COG0327  128 ----------------------------------------------------PSGGEGLGRIGELPEPMTLEELAARVKE 155
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231601 239 HLHLPHLRLALGSGKTLEssvRVaAVCAGSGSSILG-----GipADLYLTGEMSHHDVLDAVAEGRSVVLCEHSNSERGY 313
Cdd:COG0327  156 ALGLRGVRVVGDPDRPIR---RV-AICTGSGQSLIEeaaaaG--ADAYITGEIKEHTAHDAREQGIALIDAGHYATERPG 229
                        330       340
                 ....*....|....*....|....*..
gi 148231601 314 LQELGGQIHQALEgqVQVVVSQRDRDP 340
Cdd:COG0327  230 VQALAEWLAEAFG--LEVEFIDIDNPP 254
YbgI_SA1388 TIGR00486
dinuclear metal center protein, YbgI/SA1388 family; The characterization of this family of ...
1-340 1.12e-38

dinuclear metal center protein, YbgI/SA1388 family; The characterization of this family of uncharacterized proteins as orthologous is tentative. Members are found in all three domains of life. Several members (from Bacillus subtilis, Listeria monocytogenes, and Mycobacterium tuberculosis - all classified as Firmicutes within the Eubacteria) share a long insert relative to other members. [Unknown function, General]


Pssm-ID: 213534  Cd Length: 249  Bit Score: 137.91  E-value: 1.12e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231601    1 MDLGSVVSHLNALTPPALAEGWDNVGLLVEpSPPHQVHKLLLTNDLTEDVLDEAINMEANMILSYHPPVFKALKRVTQKN 80
Cdd:TIGR00486   1 MNLDELIQLINRFLPKELAEDGDNNGLQVG-SGNEEVKKVVVAVDASESVADEAVRLGADLIITHHPLIWKPLKRLIRGI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231601   81 WKERLVvKALEKRLAIYSPHTSCDALANGVNDWLARALGpsksvplhastsltypggfghllefrldtAENIFsrlksiq 160
Cdd:TIGR00486  80 KPGRLK-ILLQNDISLYSAHTNLDAHDGGNNDALARALG-----------------------------LENPK------- 122
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231601  161 gvsvctstaspegqnvslscsqnalvealailseephvynslqllslqkpPLVDTGMGRLCTLAEPVSIAAAVERIKKHL 240
Cdd:TIGR00486 123 --------------------------------------------------EFEDYGLGRVGEFKAPIESLEEVLEIKKVL 152
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231601  241 HLPHLRLAlgsgKTLESSVRVAAVCAGSGSS-----ILGGipADLYLTGEMSHHDVLDAVAEGRSVVLCEHSNSERGYLQ 315
Cdd:TIGR00486 153 NVKPLLVV----KNGPEYVKKVAVVSGSGLSfimkaLREG--VDAYITGDLSHHTAHLARELGLNVIDAGHYATERGGLR 226
                         330       340
                  ....*....|....*....|....*
gi 148231601  316 ELGGQIHQALEgqVQVVVSQRDRDP 340
Cdd:TIGR00486 227 KLMEDLNENEG--LEVVFSDIPTNA 249
 
Name Accession Description Interval E-value
NIF3 pfam01784
NIF3 (NGG1p interacting factor 3); This family contains several NIF3 (NGG1p interacting factor ...
6-323 1.41e-69

NIF3 (NGG1p interacting factor 3); This family contains several NIF3 (NGG1p interacting factor 3) protein homologs. NIF3 interacts with the yeast transcriptional coactivator NGG1p which is part of the ADA complex, the exact function of this interaction is unknown.


Pssm-ID: 426431  Cd Length: 236  Bit Score: 217.10  E-value: 1.41e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231601    6 VVSHLNALTPPALAEGWDNVGLLVEpSPPHQVHKLLLTNDLTEDVLDEAINMEANMILSYHPPVFKALKRVTQKNWKERL 85
Cdd:pfam01784   2 IIELLEEIAPPELAEDWDNVGLQVG-DPENEVTKILVALDATEEVIEEAIENGADLIITHHPLIFRPLKSLTGDDPKGRR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231601   86 VVKALEKRLAIYSPHTSCDALANGVNDWLARALGPSKSVPLhastsltypggfghllefrldtaenifsrlksiqgvsvc 165
Cdd:pfam01784  81 IKKLIKNNISLYSAHTNLDAAPGGVNDWLAELLGLESIEPL--------------------------------------- 121
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231601  166 tstaspegqnvslscsqnalvealailseephvynslqllslqKPPLVDTGMGRLCTLAEPVSIAAAVERIKKHLHLPHL 245
Cdd:pfam01784 122 -------------------------------------------EPTEEGEGLGRIGELPEPMSLEELAAKVKEKLGLEGV 158
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231601  246 RLALGsgktLESSVRVAAVCAGSGSSILGGI---PADLYLTGEMSHHDVLDAVAEGRSVVLCEHSNSERGYLQELGGQIH 322
Cdd:pfam01784 159 RVVGD----LDKPIKKVAICGGSGSSLIDEAkakGADVLITGDVKYHDALDAQEKGINLIDAGHYATERFGLEALAELLK 234

                  .
gi 148231601  323 Q 323
Cdd:pfam01784 235 E 235
NIF3 COG0327
Putative GTP cyclohydrolase 1 type 2, NIF3 family [Coenzyme transport and metabolism]; ...
1-340 9.12e-52

Putative GTP cyclohydrolase 1 type 2, NIF3 family [Coenzyme transport and metabolism]; Putative GTP cyclohydrolase 1 type 2, NIF3 family is part of the Pathway/BioSystem: Folate biosynthesis


Pssm-ID: 440096  Cd Length: 254  Bit Score: 171.87  E-value: 9.12e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231601   1 MDLGSVVSHLNALTPPALAEGWDNVGLLV-EPSPPhqVHKLLLTNDLTEDVLDEAINMEANMILSYHPPVFKALKRVTQK 79
Cdd:COG0327    1 MTLSELVAALEELLPPALAESWDPNGLQVgEGRAE--VTRIVTAVDATQAVIEEAIEAGADLLIVHHPLFWKGEDSITAG 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231601  80 NWKERLVVKALEKRLAIYSPHTSCDA-LANGVNDWLARALGpsksvplhastsLTYPGGFGhllefrldtaenifsrlks 158
Cdd:COG0327   79 TVKGRRLALLIKNDIALYAAHTPLDAhPELGNNAQLARLLG------------LEDVEPLG------------------- 127
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231601 159 iqgvsvctstaspegqnvslscsqnalvealailseephvynslqllslqkpPLVDTGMGRLCTLAEPVSIAAAVERIKK 238
Cdd:COG0327  128 ----------------------------------------------------PSGGEGLGRIGELPEPMTLEELAARVKE 155
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231601 239 HLHLPHLRLALGSGKTLEssvRVaAVCAGSGSSILG-----GipADLYLTGEMSHHDVLDAVAEGRSVVLCEHSNSERGY 313
Cdd:COG0327  156 ALGLRGVRVVGDPDRPIR---RV-AICTGSGQSLIEeaaaaG--ADAYITGEIKEHTAHDAREQGIALIDAGHYATERPG 229
                        330       340
                 ....*....|....*....|....*..
gi 148231601 314 LQELGGQIHQALEgqVQVVVSQRDRDP 340
Cdd:COG0327  230 VQALAEWLAEAFG--LEVEFIDIDNPP 254
YbgI_SA1388 TIGR00486
dinuclear metal center protein, YbgI/SA1388 family; The characterization of this family of ...
1-340 1.12e-38

dinuclear metal center protein, YbgI/SA1388 family; The characterization of this family of uncharacterized proteins as orthologous is tentative. Members are found in all three domains of life. Several members (from Bacillus subtilis, Listeria monocytogenes, and Mycobacterium tuberculosis - all classified as Firmicutes within the Eubacteria) share a long insert relative to other members. [Unknown function, General]


Pssm-ID: 213534  Cd Length: 249  Bit Score: 137.91  E-value: 1.12e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231601    1 MDLGSVVSHLNALTPPALAEGWDNVGLLVEpSPPHQVHKLLLTNDLTEDVLDEAINMEANMILSYHPPVFKALKRVTQKN 80
Cdd:TIGR00486   1 MNLDELIQLINRFLPKELAEDGDNNGLQVG-SGNEEVKKVVVAVDASESVADEAVRLGADLIITHHPLIWKPLKRLIRGI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231601   81 WKERLVvKALEKRLAIYSPHTSCDALANGVNDWLARALGpsksvplhastsltypggfghllefrldtAENIFsrlksiq 160
Cdd:TIGR00486  80 KPGRLK-ILLQNDISLYSAHTNLDAHDGGNNDALARALG-----------------------------LENPK------- 122
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231601  161 gvsvctstaspegqnvslscsqnalvealailseephvynslqllslqkpPLVDTGMGRLCTLAEPVSIAAAVERIKKHL 240
Cdd:TIGR00486 123 --------------------------------------------------EFEDYGLGRVGEFKAPIESLEEVLEIKKVL 152
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148231601  241 HLPHLRLAlgsgKTLESSVRVAAVCAGSGSS-----ILGGipADLYLTGEMSHHDVLDAVAEGRSVVLCEHSNSERGYLQ 315
Cdd:TIGR00486 153 NVKPLLVV----KNGPEYVKKVAVVSGSGLSfimkaLREG--VDAYITGDLSHHTAHLARELGLNVIDAGHYATERGGLR 226
                         330       340
                  ....*....|....*....|....*
gi 148231601  316 ELGGQIHQALEgqVQVVVSQRDRDP 340
Cdd:TIGR00486 227 KLMEDLNENEG--LEVVFSDIPTNA 249
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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