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Conserved domains on  [gi|147903361|ref|NP_001088864|]
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mannose-6-phosphate receptor (cation dependent) S homeolog [Xenopus laevis]

Protein Classification

cation-dependent mannose-6-phosphate receptor( domain architecture ID 1563581)

cation-dependent mannose 6-phosphate receptor (CD-MPR) is a key component of the lysosomal enzyme targeting system that binds newly synthesized mannose 6-phosphate (Man-6-P)-containing acid hydrolases and transports them to endosomal compartments

Gene Ontology:  GO:0015031
PubMed:  3156583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ATG27 super family cl39051
Autophagy-related protein 27;
1-138 1.42e-99

Autophagy-related protein 27;


The actual alignment was detected with superfamily member pfam02157:

Pssm-ID: 476860  Cd Length: 254  Bit Score: 285.90  E-value: 1.42e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147903361    1 MVMISCSKKTLGGDFTVVQEERNKSRECFYLFEMDSSLACPPEESHLSVGSILLIVFAVLVAVYIVGGFLYQRFVVGAKG 80
Cdd:pfam02157 117 IIMISCNRKVLADNFTIVIEEREKEQDCFYLFELDSSLACPPEDSHLSVGSILLIVFFSLVAVYIIGGFLYQRLVVGAKG 196

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 147903361   81 MEQFPNITFWQELGNLMADGCDFVCRSRPRTSDTAYRGVGDDQLAEEPEERDDHLLPM 138
Cdd:pfam02157 197 MEQFPNYAFWQDLGNLVADGCDFVCRSKPRNAPAAYRGVGDDQLGEESEERDDHLLPM 254
 
Name Accession Description Interval E-value
Man-6-P_recep pfam02157
Mannose-6-phosphate receptor; This family includes both Cation-dependent and cation ...
 1-138 1.42e-99

Mannose-6-phosphate receptor; This family includes both Cation-dependent and cation independent mannose-6-phosphate receptors.


Pssm-ID: 460468  Cd Length: 254  Bit Score: 285.90  E-value: 1.42e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147903361    1 MVMISCSKKTLGGDFTVVQEERNKSRECFYLFEMDSSLACPPEESHLSVGSILLIVFAVLVAVYIVGGFLYQRFVVGAKG 80
Cdd:pfam02157 117 IIMISCNRKVLADNFTIVIEEREKEQDCFYLFELDSSLACPPEDSHLSVGSILLIVFFSLVAVYIIGGFLYQRLVVGAKG 196

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 147903361   81 MEQFPNITFWQELGNLMADGCDFVCRSRPRTSDTAYRGVGDDQLAEEPEERDDHLLPM 138
Cdd:pfam02157 197 MEQFPNYAFWQDLGNLVADGCDFVCRSKPRNAPAAYRGVGDDQLGEESEERDDHLLPM 254
 
Name Accession Description Interval E-value
Man-6-P_recep pfam02157
Mannose-6-phosphate receptor; This family includes both Cation-dependent and cation ...
 1-138 1.42e-99

Mannose-6-phosphate receptor; This family includes both Cation-dependent and cation independent mannose-6-phosphate receptors.


Pssm-ID: 460468  Cd Length: 254  Bit Score: 285.90  E-value: 1.42e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147903361    1 MVMISCSKKTLGGDFTVVQEERNKSRECFYLFEMDSSLACPPEESHLSVGSILLIVFAVLVAVYIVGGFLYQRFVVGAKG 80
Cdd:pfam02157 117 IIMISCNRKVLADNFTIVIEEREKEQDCFYLFELDSSLACPPEDSHLSVGSILLIVFFSLVAVYIIGGFLYQRLVVGAKG 196

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 147903361   81 MEQFPNITFWQELGNLMADGCDFVCRSRPRTSDTAYRGVGDDQLAEEPEERDDHLLPM 138
Cdd:pfam02157 197 MEQFPNYAFWQDLGNLVADGCDFVCRSKPRNAPAAYRGVGDDQLGEESEERDDHLLPM 254
ATG27 pfam09451
Autophagy-related protein 27;
41-105 1.90e-05

Autophagy-related protein 27;


Pssm-ID: 430622  Cd Length: 261  Bit Score: 42.71  E-value: 1.90e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 147903361   41 PPEESHLSVGSILLIVFAVLVAVYIVGGFLYQRFVVGAKGMEQFPNITFWQELGNLMADGCDFVC 105
Cdd:pfam09451 186 GNGGSGWGWFTWFFIILFLFTAAYLIFGSWLNYNRYGARGWDLLPHGDFWRDLPYLLKDVVRKVV 250
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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