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Conserved domains on  [gi|147902688|ref|NP_001079679|]
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lipase maturation factor 2 [Xenopus laevis]

Protein Classification

lipase maturation factor family protein( domain architecture ID 10535984)

lipase maturation factor family protein similar to vertebrate lipase maturation factor, which is involved in the maturation of specific proteins in the endoplasmic reticulum, and may be required for maturation and transport of active lipoprotein lipase through the secretory pathway

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LMF1 pfam06762
Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation ...
 122-584 0e+00

Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. It acts as a chaperone required for maturation and transport of active lipoprotein lipase (LPL), through the secretory pathway.


:

Pssm-ID: 462004  Cd Length: 419  Bit Score: 573.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902688  122 LYFQWDSLLLETGFLAILVAPLHAMRWKTSvwSAHDGVTFWLTRWLLFRLMFASGVVKLTSRCPTWWGLTALTYHYETQC 201
Cdd:pfam06762   1 YSFQWDSLLLETGFLAIFLAPLGLLRRLPK--SPPPSIVFWLVRWLLFRLMFGAGLVKLRSDCPTWWDLTALDYHYETQP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902688  202 IPNPAAWYAHQLPVWLQKFSVVATFFIEIGVPWLFFLPFRRLRLFSFYSQVLLQILIIITGNYNFFNLLTIVLCCSMLDD 281
Cdd:pfam06762  79 LPTPLSWYAHQLPSWFHKLETLGNHVVELVVPFLFFAPIRRLRIVAFFIQVLLQLLIILTGNYGFLNLLTIVLSLSLLDD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902688  282 QHIAFFQRHKKTQhkggiATSAFSLRSLVSLLEIPIFGLLVFWTVKYFDLQINwdkhslesrtaftyhDFQQWLRTITFP 361
Cdd:pfam06762 159 AFLYFWTPESRKK-----PPRTRLLSVIETLLSLLVYGLLIYGTVSLFGLKIS---------------ENGTFLRRVTLP 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902688  362 SIWIAAASLGWEILKGMYRSasvrgffWKLWSTLQWLMFSCAAAAMFTISLVPYTymdfesngqLWPEVHQMFNTVDRYQ 441
Cdd:pfam06762 219 SIVLGLVSLLSVPVCALLRS-------NKLIQSIQLAIVTLAAVLLFALSLVPFS---------VRNLLSRMNASFNPLH 282

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902688  442 LVNSYGLFRRMTgvGGRPEVVVEGSFDRET-WTEIEFMYKPGNISTIPTVIVPHQPRLDWQMWFAALSHHSHSPWFASFV 520
Cdd:pfam06762 283 LVNSYGLFGSMT--GGRPEVVIEGSNDGEGpWKEYEFKYKPGDVNRRPPFVAPYHPRLDWQMWFAALGTYQQNPWFLSLL 360

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 147902688  521 YRLLQGNKDVIHLVQNdeslYPFHANPPTYIRAQQYKYWFTEVDQSGHmPKSWWRRRHVEEFFP 584
Cdd:pfam06762 361 YRLLQNDPEVLGLLDH----NPFPDKPPKYVRAELYRYRFTTPGERRA-TGAWWKRERVGEYFP 419
 
Name Accession Description Interval E-value
LMF1 pfam06762
Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation ...
 122-584 0e+00

Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. It acts as a chaperone required for maturation and transport of active lipoprotein lipase (LPL), through the secretory pathway.


Pssm-ID: 462004  Cd Length: 419  Bit Score: 573.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902688  122 LYFQWDSLLLETGFLAILVAPLHAMRWKTSvwSAHDGVTFWLTRWLLFRLMFASGVVKLTSRCPTWWGLTALTYHYETQC 201
Cdd:pfam06762   1 YSFQWDSLLLETGFLAIFLAPLGLLRRLPK--SPPPSIVFWLVRWLLFRLMFGAGLVKLRSDCPTWWDLTALDYHYETQP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902688  202 IPNPAAWYAHQLPVWLQKFSVVATFFIEIGVPWLFFLPFRRLRLFSFYSQVLLQILIIITGNYNFFNLLTIVLCCSMLDD 281
Cdd:pfam06762  79 LPTPLSWYAHQLPSWFHKLETLGNHVVELVVPFLFFAPIRRLRIVAFFIQVLLQLLIILTGNYGFLNLLTIVLSLSLLDD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902688  282 QHIAFFQRHKKTQhkggiATSAFSLRSLVSLLEIPIFGLLVFWTVKYFDLQINwdkhslesrtaftyhDFQQWLRTITFP 361
Cdd:pfam06762 159 AFLYFWTPESRKK-----PPRTRLLSVIETLLSLLVYGLLIYGTVSLFGLKIS---------------ENGTFLRRVTLP 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902688  362 SIWIAAASLGWEILKGMYRSasvrgffWKLWSTLQWLMFSCAAAAMFTISLVPYTymdfesngqLWPEVHQMFNTVDRYQ 441
Cdd:pfam06762 219 SIVLGLVSLLSVPVCALLRS-------NKLIQSIQLAIVTLAAVLLFALSLVPFS---------VRNLLSRMNASFNPLH 282

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902688  442 LVNSYGLFRRMTgvGGRPEVVVEGSFDRET-WTEIEFMYKPGNISTIPTVIVPHQPRLDWQMWFAALSHHSHSPWFASFV 520
Cdd:pfam06762 283 LVNSYGLFGSMT--GGRPEVVIEGSNDGEGpWKEYEFKYKPGDVNRRPPFVAPYHPRLDWQMWFAALGTYQQNPWFLSLL 360

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 147902688  521 YRLLQGNKDVIHLVQNdeslYPFHANPPTYIRAQQYKYWFTEVDQSGHmPKSWWRRRHVEEFFP 584
Cdd:pfam06762 361 YRLLQNDPEVLGLLDH----NPFPDKPPKYVRAELYRYRFTTPGERRA-TGAWWKRERVGEYFP 419
 
Name Accession Description Interval E-value
LMF1 pfam06762
Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation ...
 122-584 0e+00

Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. It acts as a chaperone required for maturation and transport of active lipoprotein lipase (LPL), through the secretory pathway.


Pssm-ID: 462004  Cd Length: 419  Bit Score: 573.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902688  122 LYFQWDSLLLETGFLAILVAPLHAMRWKTSvwSAHDGVTFWLTRWLLFRLMFASGVVKLTSRCPTWWGLTALTYHYETQC 201
Cdd:pfam06762   1 YSFQWDSLLLETGFLAIFLAPLGLLRRLPK--SPPPSIVFWLVRWLLFRLMFGAGLVKLRSDCPTWWDLTALDYHYETQP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902688  202 IPNPAAWYAHQLPVWLQKFSVVATFFIEIGVPWLFFLPFRRLRLFSFYSQVLLQILIIITGNYNFFNLLTIVLCCSMLDD 281
Cdd:pfam06762  79 LPTPLSWYAHQLPSWFHKLETLGNHVVELVVPFLFFAPIRRLRIVAFFIQVLLQLLIILTGNYGFLNLLTIVLSLSLLDD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902688  282 QHIAFFQRHKKTQhkggiATSAFSLRSLVSLLEIPIFGLLVFWTVKYFDLQINwdkhslesrtaftyhDFQQWLRTITFP 361
Cdd:pfam06762 159 AFLYFWTPESRKK-----PPRTRLLSVIETLLSLLVYGLLIYGTVSLFGLKIS---------------ENGTFLRRVTLP 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902688  362 SIWIAAASLGWEILKGMYRSasvrgffWKLWSTLQWLMFSCAAAAMFTISLVPYTymdfesngqLWPEVHQMFNTVDRYQ 441
Cdd:pfam06762 219 SIVLGLVSLLSVPVCALLRS-------NKLIQSIQLAIVTLAAVLLFALSLVPFS---------VRNLLSRMNASFNPLH 282

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147902688  442 LVNSYGLFRRMTgvGGRPEVVVEGSFDRET-WTEIEFMYKPGNISTIPTVIVPHQPRLDWQMWFAALSHHSHSPWFASFV 520
Cdd:pfam06762 283 LVNSYGLFGSMT--GGRPEVVIEGSNDGEGpWKEYEFKYKPGDVNRRPPFVAPYHPRLDWQMWFAALGTYQQNPWFLSLL 360

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 147902688  521 YRLLQGNKDVIHLVQNdeslYPFHANPPTYIRAQQYKYWFTEVDQSGHmPKSWWRRRHVEEFFP 584
Cdd:pfam06762 361 YRLLQNDPEVLGLLDH----NPFPDKPPKYVRAELYRYRFTTPGERRA-TGAWWKRERVGEYFP 419
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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