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Conserved domains on  [gi|147900656|ref|NP_001079418|]
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myelin protein zero-like protein 3 precursor [Xenopus laevis]

Protein Classification

immunoglobulin domain-containing family protein( domain architecture ID 34076)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 17-132 2.06e-36

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05880:

Pssm-ID: 472250  Cd Length: 116  Bit Score: 124.17  E-value: 2.06e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900656  17 IDISMHPDAFGVVGKSIKLKCSFTSSYPISDIVAVDWTYRQLNGGSTVTILHFQNKPYPILEGPFKDRIIWEGDVRRGDA 96
Cdd:cd05880    1 IEVYTSKEVEAVNGTDVRLKCTFSSSAPIGDTLVITWNFRPLDGGREESVFYYHKRPYPPPDGRFKGRVVWDGNIMRRDA 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 147900656  97 SISLTDLRLTDNGTLSCIVWNPPDVHGNVPQTKLTV 132
Cdd:cd05880   81 SILIWQLQPTDNGTYTCQVKNPPDVHGPIGEIRLRV 116
 
Name Accession Description Interval E-value
IgV_EVA1 cd05880
Immunoglobulin (Ig)-like domain of epithelial V-like antigen (EVA) 1; The members here are ...
 17-132 2.06e-36

Immunoglobulin (Ig)-like domain of epithelial V-like antigen (EVA) 1; The members here are composed of the immunoglobulin (Ig) domain of epithelial V-like antigen 1 (EVA 1). EVA is also known as myelin protein zero-like 2. EVA is an adhesion molecule and may play a role in the structural organization of the thymus and early lymphocyte development.


Pssm-ID: 409464  Cd Length: 116  Bit Score: 124.17  E-value: 2.06e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900656  17 IDISMHPDAFGVVGKSIKLKCSFTSSYPISDIVAVDWTYRQLNGGSTVTILHFQNKPYPILEGPFKDRIIWEGDVRRGDA 96
Cdd:cd05880    1 IEVYTSKEVEAVNGTDVRLKCTFSSSAPIGDTLVITWNFRPLDGGREESVFYYHKRPYPPPDGRFKGRVVWDGNIMRRDA 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 147900656  97 SISLTDLRLTDNGTLSCIVWNPPDVHGNVPQTKLTV 132
Cdd:cd05880   81 SILIWQLQPTDNGTYTCQVKNPPDVHGPIGEIRLRV 116
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 27-133 1.54e-18

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 77.88  E-value: 1.54e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900656   27 GVVGKSIKLKCSFTSSYPiSDIVAVDWTYRQLNGGSTVTILHFQNKpYPilEGPFKDRIIWEGDVRRGDASISLTDLRLT 106
Cdd:pfam07686   8 VALGGSVTLPCTYSSSMS-EASTSVYWYRQPPGKGPTFLIAYYSNG-SE--EGVKKGRFSGRGDPSNGDGSLTIQNLTLS 83

                          90       100
                  ....*....|....*....|....*..
gi 147900656  107 DNGTLSCIVWNPPDVHGNvPQTKLTVT 133
Cdd:pfam07686  84 DSGTYTCAVIPSGEGVFG-KGTRLTVL 109
IGv smart00406
Immunoglobulin V-Type;
32-115 1.14e-07

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 47.76  E-value: 1.14e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900656    32 SIKLKCSFtSSYPISDIVaVDWtYRQLNGGSTVTILHFQNKPYPILEGPFKDRIIWEGDVRRGDASISLTDLRLTDNGTL 111
Cdd:smart00406   1 SVTLSCKF-SGSTFSSYY-VSW-VRQPPGKGLEWLGYIGSNGSSYYQESYKGRFTISKDTSKNDVSLTISNLRVEDTGTY 77


                   ....
gi 147900656   112 SCIV 115
Cdd:smart00406  78 YCAV 81
 
Name Accession Description Interval E-value
IgV_EVA1 cd05880
Immunoglobulin (Ig)-like domain of epithelial V-like antigen (EVA) 1; The members here are ...
 17-132 2.06e-36

Immunoglobulin (Ig)-like domain of epithelial V-like antigen (EVA) 1; The members here are composed of the immunoglobulin (Ig) domain of epithelial V-like antigen 1 (EVA 1). EVA is also known as myelin protein zero-like 2. EVA is an adhesion molecule and may play a role in the structural organization of the thymus and early lymphocyte development.


Pssm-ID: 409464  Cd Length: 116  Bit Score: 124.17  E-value: 2.06e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900656  17 IDISMHPDAFGVVGKSIKLKCSFTSSYPISDIVAVDWTYRQLNGGSTVTILHFQNKPYPILEGPFKDRIIWEGDVRRGDA 96
Cdd:cd05880    1 IEVYTSKEVEAVNGTDVRLKCTFSSSAPIGDTLVITWNFRPLDGGREESVFYYHKRPYPPPDGRFKGRVVWDGNIMRRDA 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 147900656  97 SISLTDLRLTDNGTLSCIVWNPPDVHGNVPQTKLTV 132
Cdd:cd05880   81 SILIWQLQPTDNGTYTCQVKNPPDVHGPIGEIRLRV 116
IgV_P0-like cd05715
Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here ...
 26-132 5.09e-35

Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here are composed of the immunoglobulin (Ig) domain of protein zero (P0), a myelin membrane adhesion molecule. P0 accounts for over 50% of the total protein in peripheral nervous system (PNS) myelin. P0 is a single-pass transmembrane glycoprotein with a highly basic intracellular domain and an extracellular Ig domain. The extracellular domain of P0 (P0-ED) is similar to the Ig variable domain, carrying one acceptor sequence for N-linked glycosylation. P0 plays a role in membrane adhesion in the spiral wraps of the myelin sheath. The intracellular domain is thought to mediate membrane apposition of the cytoplasmic faces and may, through electrostatic interactions, interact directly with lipid headgroups. It is thought that homophilic interactions of the P0 extracellular domain mediate membrane juxtaposition in the extracellular space of PNS myelin. This group also contains the Ig domain of sodium channel subunit beta-2 (SCN2B), and of epithelial V-like antigen 1 (EVA). EVA, also known as myelin protein zero-like 2, is an adhesion molecule, which may play a role in structural organization of the thymus and early lymphocyte development. SCN2B subunits play a role in determining sodium channel density and function in neurons,and in control of electrical excitability in the brain.


Pssm-ID: 409380  Cd Length: 117  Bit Score: 120.61  E-value: 5.09e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900656  26 FGVVGKSIKLKCSFTSSYPISDIVAVDWTYRQLNGGSTVTILH-FQNKPYPILEGPFKDRIIWEGDVRRGDASISLTDLR 104
Cdd:cd05715   10 NVLNGSDVRLTCTFTSCYTVGDAFSVTWTYQPEGGNTTESMFHySKGKPYILKVGRFKDRVSWAGNPSKKDASIVISNLQ 89

                         90       100
                 ....*....|....*....|....*...
gi 147900656 105 LTDNGTLSCIVWNPPDVHGNVPQTKLTV 132
Cdd:cd05715   90 FSDNGTYTCDVKNPPDIVGGHGEIRLYV 117
IgV_P0 cd05879
Immunoglobulin (Ig)-like domain of protein zero (P0); The members here are composed of the ...
 24-132 1.01e-26

Immunoglobulin (Ig)-like domain of protein zero (P0); The members here are composed of the immunoglobulin (Ig) domain of protein zero (P0), a myelin membrane adhesion molecule. P0 accounts for over 50% of the total protein in peripheral nervous system (PNS) myelin. P0 is a single-pass transmembrane glycoprotein with a highly basic intracellular domain and an Ig domain. The extracellular domain of P0 (P0-ED) is similar to the Ig variable domain, carrying one acceptor sequence for N-linked glycosylation. P0 plays a role in membrane adhesion in the spiral wraps of the myelin sheath. The intracellular domain is thought to mediate membrane apposition of the cytoplasmic faces and may, through electrostatic interactions, interact directly with lipid headgroups. It is thought that homophilic interactions of the P0 extracellular domain mediate membrane juxtaposition in the extracellular space of PNS myelin.


Pssm-ID: 409463  Cd Length: 117  Bit Score: 99.18  E-value: 1.01e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900656  24 DAFGVVGKSIKLKCSFTSSYPISDIVAVDWTYRQLNGGSTVTILHF-QNKPYPILEGPFKDRIIWEGDVRRGDASISLTD 102
Cdd:cd05879    8 EVYGTVGSDVTLSCSFWSSEWISDDISFTWHYQPDGSRDAISIFHYgKGQPYIDNVGPFKERIEWVGNPSRKDGSIVIHN 87

                         90       100       110
                 ....*....|....*....|....*....|
gi 147900656 103 LRLTDNGTLSCIVWNPPDVHGNVPQTKLTV 132
Cdd:cd05879   88 LDYTDNGTFTCDVKNPPDIVGKSSQVTLYV 117
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 27-133 1.54e-18

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 77.88  E-value: 1.54e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900656   27 GVVGKSIKLKCSFTSSYPiSDIVAVDWTYRQLNGGSTVTILHFQNKpYPilEGPFKDRIIWEGDVRRGDASISLTDLRLT 106
Cdd:pfam07686   8 VALGGSVTLPCTYSSSMS-EASTSVYWYRQPPGKGPTFLIAYYSNG-SE--EGVKKGRFSGRGDPSNGDGSLTIQNLTLS 83

                          90       100
                  ....*....|....*....|....*..
gi 147900656  107 DNGTLSCIVWNPPDVHGNvPQTKLTVT 133
Cdd:pfam07686  84 DSGTYTCAVIPSGEGVFG-KGTRLTVL 109
IgV_CAR_like cd20960
Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and ...
 28-122 7.89e-11

Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins; The members here are composed of the Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins. CAR, which is encoded by human CXADR gene, is a cell adhesion molecule of the Immunoglobulin (Ig) superfamily. The CAR acts as a type I membrane receptor for group B1-B6 coxsackie viruses and subgroup C adenoviruses. For instance, adenovirus interacts with the coxsackievirus and adenovirus receptor to enter epithelial airway cells. The CAR is also shown to be involved in physiological processes such as neuronal and heart development, epithelial tight junction integrity, and tumor suppression. The CAR is a component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. The CAR is also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. The CAR is composed of one V-set and one C2-set Ig module, a single transmembrane helix, and an intracellular domain. This group belongs to the V-set of IgSF domains, having A, B, E and D strands in one beta-sheet and A', G, F, C, C' and C" in the other


Pssm-ID: 409552  Cd Length: 114  Bit Score: 57.46  E-value: 7.89e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900656  28 VVGKSIKLKCSFTSSYPISDIVAVDWTYRQLNGGSTVTILHFQNKPYPILEGPFKDRIIWEGDVRRGDASISLTDLRLTD 107
Cdd:cd20960   13 VAGENVTLPCHHQLGLEDQGTLDIEWLLLPSDKVEKVVITYSGDRVYNHYYPALKGRVAFTSNDLSGDASLNISNLKLSD 92

                         90
                 ....*....|....*
gi 147900656 108 NGTLSCIVWNPPDVH 122
Cdd:cd20960   93 TGTYQCKVKKAPGYA 107
IGv smart00406
Immunoglobulin V-Type;
32-115 1.14e-07

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 47.76  E-value: 1.14e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900656    32 SIKLKCSFtSSYPISDIVaVDWtYRQLNGGSTVTILHFQNKPYPILEGPFKDRIIWEGDVRRGDASISLTDLRLTDNGTL 111
Cdd:smart00406   1 SVTLSCKF-SGSTFSSYY-VSW-VRQPPGKGLEWLGYIGSNGSSYYQESYKGRFTISKDTSKNDVSLTISNLRVEDTGTY 77


                   ....
gi 147900656   112 SCIV 115
Cdd:smart00406  78 YCAV 81
IgV_1_Nectin-1_like cd05886
First immunoglobulin variable (IgV) domain of nectin-1, and similar domains; The members here ...
 19-113 1.06e-05

First immunoglobulin variable (IgV) domain of nectin-1, and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of nectin-1 (also known as poliovirus receptor related protein 1 (PVRL1) or cluster of differentiation (CD) 111). Nectin-1 belongs to the nectin family comprised of four transmembrane glycoproteins (nectins-1 through -4). Nectins are synaptic cell adhesion molecules (CAMs) which facilitate adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. In addition nectins heterophilically trans-interact with other CAMs such as nectin-like molecules (Necls), nectin-1 for example, has been shown to trans-interact with Necl-1. Nectins also interact with various other proteins, including the actin filament (F-actin)-binding protein, afadin. Mutation in the human nectin-1 gene is associated with cleft lip/palate ectodermal dysplasia syndrome (CLPED1). Nectin-1 is a major receptor for herpes simplex virus through interaction with the viral envelope glycoprotein D.


Pssm-ID: 409469  Cd Length: 113  Bit Score: 43.41  E-value: 1.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900656  19 ISMHPDAFGVVGKSIKLKCSFTSSYPISDIVAVDWtyRQLNGGSTVTILHFQNKPYPILEGPFKDRIIWegdvRRG---D 95
Cdd:cd05886    3 VQVNDSMSGFIGTDVVLHCSFANPLPSVKITQVTW--QKSTNGSKQNVAIYNPSMGVSVLPPYRERVTF----LNPsftD 76

                         90
                 ....*....|....*...
gi 147900656  96 ASISLTDLRLTDNGTLSC 113
Cdd:cd05886   77 GTIRLSRLELEDEGVYIC 94
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
 19-113 4.12e-04

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 38.97  E-value: 4.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900656  19 ISMHPDAFGVVGKSIKLKCSFTSSYPISdIVAVDWTYRQLNGGSTVTILHFQNKpyPILEGPFKDRIiwEGDVRR---GD 95
Cdd:cd05718    3 VQVPTEVTGFLGGSVTLPCSLTSPGTTK-ITQVTWMKIGAGSSQNVAVFHPQYG--PSVPNPYAERV--EFLAARlglRN 77

                         90
                 ....*....|....*...
gi 147900656  96 ASISLTDLRLTDNGTLSC 113
Cdd:cd05718   78 ATLRIRNLRVEDEGNYIC 95
IgV_B7-H4 cd20984
Immunoglobulin Variable (IgV) domain of B7-H4; The members here are composed of the ...
 27-117 5.31e-04

Immunoglobulin Variable (IgV) domain of B7-H4; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H4 (also known as B7-S1, B7x, or Vtcn1). B7-H4 is one of the B7 family of immune-regulatory ligands that act as negative regulators of T cell function; it contains one IgV domain and one IgC domain. The B7-family consists of structurally related cell-surface protein ligands, which bind to receptors on lymphocytes that regulate immune responses. The binding of B7-H4 to unidentified receptors results in the inhibition of TCR-mediated T cell proliferation, cell-cycle progression and IL-2 production. As a co-inhibitory molecule, B7-H4 is widely expressed in tumor tissues and its expression is significantly associated with poor prognosis in human cancers such as glioma, pancreatic cancer, oral squamous cell carcinoma, renal cell carcinoma, and lung cancer.


Pssm-ID: 409576  Cd Length: 110  Bit Score: 38.35  E-value: 5.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900656  27 GVVGKSIKLKCSFTSSYPISDIVaVDWTYRQLNGgsTVTILHFQNKPYPILEGPFKDRI-IWEGDVRRGDASISLTDLRL 105
Cdd:cd20984    9 GNIGEDGILSCTFTPDIKLSDIV-IQWLKEGDSG--LVHEFKEGKDELSRQSPMFRGRTsLFADQVHVGNASLRLKNVQL 85

                         90
                 ....*....|..
gi 147900656 106 TDNGTLSCIVWN 117
Cdd:cd20984   86 TDAGTYLCIISN 97
Ig_CSPGs_LP_like cd05714
Immunoglobulin (Ig)-like domain of chondroitin sulfate proteoglycans (CSPGs), human cartilage ...
 23-115 3.85e-03

Immunoglobulin (Ig)-like domain of chondroitin sulfate proteoglycans (CSPGs), human cartilage link protein (LP), and similar domains; The members here are composed of the immunoglobulin (Ig)-like domain similar to that found in chondroitin sulfate proteoglycans (CSPGs) and human cartilage link protein (LP). Included in this group are the CSPGs aggrecan, versican, and neurocan. In CSPGs, this Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggrecan and versican have a wide distribution in connective tissue and extracellular matrices. Neurocan is localized almost exclusively in nervous tissue. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. There is considerable evidence that HA-binding CSPGs are involved in developmental processes in the central nervous system. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409379  Cd Length: 123  Bit Score: 36.42  E-value: 3.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900656  23 PDAFGVVGKSIKLKCSF----TSSYPISDIVAVDWTyrqlnggsTVTILHFQNKPYPIL---EGPFKDRIIWEGDVR--- 92
Cdd:cd05714    5 AKVFSHLGGNVTLPCKFyrdpTAFGSGIHKIRIKWT--------KLTSDSGYLKEVDVLvamGNVVYHKKTYGGRVSvpl 76

                         90       100
                 ....*....|....*....|....*..
gi 147900656  93 ----RGDASISLTDLRLTDNGTLSCIV 115
Cdd:cd05714   77 kpgsDSDASLVITDLTASDYGLYRCEV 103
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 20-122 5.09e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 35.25  E-value: 5.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900656   20 SMHPDAFGVVGKSIKLKCSftsSYPISDIVAVDWtyrqlnggstvtilhFQNKPYPILEgpfkdRIIWEGDVRRGDASIS 99
Cdd:pfam00047   1 SAPPTVTVLEGDSATLTCS---ASTGSPGPDVTW---------------SKEGGTLIES-----LKVKHDNGRTTQSSLL 57

                          90       100
                  ....*....|....*....|...
gi 147900656  100 LTDLRLTDNGTLSCIVWNPPDVH 122
Cdd:pfam00047  58 ISNVTKEDAGTYTCVVNNPGGSA 80
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 27-132 6.72e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 34.79  E-value: 6.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900656    27 GVVGKSIKLKCSFTSSYPISdivaVDWtyrqlnggstvtilhFQNKPYPILEgpfKDRIIWEGDvrRGDASISLTDLRLT 106
Cdd:smart00410   6 VKEGESVTLSCEASGSPPPE----VTW---------------YKQGGKLLAE---SGRFSVSRS--GSTSTLTISNVTPE 61

                           90       100
                   ....*....|....*....|....*..
gi 147900656   107 DNGTLSCIVWNP-PDVHGNvpqTKLTV 132
Cdd:smart00410  62 DSGTYTCAATNSsGSASSG---TTLTV 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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