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Conserved domains on  [gi|148232497|ref|NP_001079109|]
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GATA-binding factor 1-A [Xenopus laevis]

Protein Classification

GATA-type transcription factor( domain architecture ID 13433091)

GATA-type transcription factor binds to the DNA consensus sequence [AT]GATA[AG] and may function as a transcription factor/regulator

CATH:  3.30.50.10
Gene Ontology:  GO:0003700|GO:0006357|GO:0008270|GO:0043565
PubMed:  31574210
SCOP:  4003617

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 231-280 1.88e-20

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 83.58  E-value: 1.88e-20
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 148232497 231 QCSNCHTSTTTLWRRN-ASGDPVCNACGLYYKLHNVNRPLTMKKEG-IQTRN 280
Cdd:cd00202    1 ACSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRN 52
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 177-221 1.34e-17

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 75.87  E-value: 1.34e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 148232497 177 ECVNCGATVTPLWRRD-MSGHYLCNACGLYHKMNGQNRPLIRPKKR 221
Cdd:cd00202    1 ACSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKD 46
GAT1 super family cl35034
GATA Zn-finger-containing transcription factor [Transcription];
107-256 9.76e-09

GATA Zn-finger-containing transcription factor [Transcription];


The actual alignment was detected with superfamily member COG5641:

Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 56.80  E-value: 9.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148232497 107 YSASSFLLGSAPPAEregSPKFLETLKTERASPLTSDLLPLEPRSPSILQVGyIGGGGQEFS-----LFQSTEDRECVNC 181
Cdd:COG5641   89 HRASSRQSSISSLSD---FPISSSSSTSNAASPSTNYTDESNQQFSSYNTTL-NPGGTSSLNpnnnqSDNSNQPHVCSNC 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148232497 182 GATVTPLWRRD-----MSGHYLCNACGLYHKMNGQNRPLIRPKKRLIVSKRAGTQCSNC-HTSTTTLWRRNASGDPVCNA 255
Cdd:COG5641  165 KTTSTPLWRRAssessLPGNNLCNACGLYLKLHGSPRAPISLKSDSIKSRSSRSSHNNNdSNGENANTESIGNSSASKLT 244


                 .
gi 148232497 256 C 256
Cdd:COG5641  245 K 245
 
Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 231-280 1.88e-20

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 83.58  E-value: 1.88e-20
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 148232497 231 QCSNCHTSTTTLWRRN-ASGDPVCNACGLYYKLHNVNRPLTMKKEG-IQTRN 280
Cdd:cd00202    1 ACSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRN 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
227-276 1.72e-19

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 80.93  E-value: 1.72e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 148232497   227 RAGTQCSNCHTSTTTLWRRNASGD-PVCNACGLYYKLHNV-NRPLTMKKEGI 276
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDGI 52
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 177-221 1.34e-17

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 75.87  E-value: 1.34e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 148232497 177 ECVNCGATVTPLWRRD-MSGHYLCNACGLYHKMNGQNRPLIRPKKR 221
Cdd:cd00202    1 ACSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKD 46
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
174-221 8.28e-15

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 67.83  E-value: 8.28e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 148232497   174 EDRECVNCGATVTPLWRRDMSGH-YLCNACGLYHKMNGQ-NRPLIRPKKR 221
Cdd:smart00401   2 SGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDG 51
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 232-266 7.38e-14

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 65.03  E-value: 7.38e-14
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 148232497  232 CSNCHTSTTTLWRRNASGDP-VCNACGLYYKLHNVN 266
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 178-212 3.86e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 62.72  E-value: 3.86e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 148232497  178 CVNCGATVTPLWRRDMSGHY-LCNACGLYHKMNGQN 212
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
125-279 1.70e-09

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 59.11  E-value: 1.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148232497 125 SPKFLETLKTERASPLTSDLLPLEPRSP----SILQVGYIGGGGQEFSLFQST--EDRECVNCG-ATVTPLWRR-DMSGH 196
Cdd:COG5641  241 SKLTKSWEERPQGRQLLSDAGSLSPRSNnpksPLLEGLMGSTSLQPVSTPKLVlpSDKKRSTLTtSTATPLWRRtSDKSS 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148232497 197 YLCNACGLYHKMNGQNRPLirPKKRLIVSKRAGTQCSNCHTSTTTLWRrnaSGDPVCNACGLYYKLHNVNRPLTMKKEGI 276
Cdd:COG5641  321 FSCNASGSALKPPGSKRPL--LPKPDPNSKRSNATCMNCSSTPTNKIL---SPPTTSNSPGAQVKLPNQTRSTGATKKKI 395


                 ...
gi 148232497 277 QTR 279
Cdd:COG5641  396 TRR 398
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
107-256 9.76e-09

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 56.80  E-value: 9.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148232497 107 YSASSFLLGSAPPAEregSPKFLETLKTERASPLTSDLLPLEPRSPSILQVGyIGGGGQEFS-----LFQSTEDRECVNC 181
Cdd:COG5641   89 HRASSRQSSISSLSD---FPISSSSSTSNAASPSTNYTDESNQQFSSYNTTL-NPGGTSSLNpnnnqSDNSNQPHVCSNC 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148232497 182 GATVTPLWRRD-----MSGHYLCNACGLYHKMNGQNRPLIRPKKRLIVSKRAGTQCSNC-HTSTTTLWRRNASGDPVCNA 255
Cdd:COG5641  165 KTTSTPLWRRAssessLPGNNLCNACGLYLKLHGSPRAPISLKSDSIKSRSSRSSHNNNdSNGENANTESIGNSSASKLT 244


                 .
gi 148232497 256 C 256
Cdd:COG5641  245 K 245
 
Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 231-280 1.88e-20

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 83.58  E-value: 1.88e-20
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 148232497 231 QCSNCHTSTTTLWRRN-ASGDPVCNACGLYYKLHNVNRPLTMKKEG-IQTRN 280
Cdd:cd00202    1 ACSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRN 52
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
227-276 1.72e-19

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 80.93  E-value: 1.72e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 148232497   227 RAGTQCSNCHTSTTTLWRRNASGD-PVCNACGLYYKLHNV-NRPLTMKKEGI 276
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDGI 52
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 177-221 1.34e-17

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 75.87  E-value: 1.34e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 148232497 177 ECVNCGATVTPLWRRD-MSGHYLCNACGLYHKMNGQNRPLIRPKKR 221
Cdd:cd00202    1 ACSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKD 46
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
174-221 8.28e-15

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 67.83  E-value: 8.28e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 148232497   174 EDRECVNCGATVTPLWRRDMSGH-YLCNACGLYHKMNGQ-NRPLIRPKKR 221
Cdd:smart00401   2 SGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLKKDG 51
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 232-266 7.38e-14

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 65.03  E-value: 7.38e-14
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 148232497  232 CSNCHTSTTTLWRRNASGDP-VCNACGLYYKLHNVN 266
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 178-212 3.86e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 62.72  E-value: 3.86e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 148232497  178 CVNCGATVTPLWRRDMSGHY-LCNACGLYHKMNGQN 212
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
125-279 1.70e-09

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 59.11  E-value: 1.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148232497 125 SPKFLETLKTERASPLTSDLLPLEPRSP----SILQVGYIGGGGQEFSLFQST--EDRECVNCG-ATVTPLWRR-DMSGH 196
Cdd:COG5641  241 SKLTKSWEERPQGRQLLSDAGSLSPRSNnpksPLLEGLMGSTSLQPVSTPKLVlpSDKKRSTLTtSTATPLWRRtSDKSS 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148232497 197 YLCNACGLYHKMNGQNRPLirPKKRLIVSKRAGTQCSNCHTSTTTLWRrnaSGDPVCNACGLYYKLHNVNRPLTMKKEGI 276
Cdd:COG5641  321 FSCNASGSALKPPGSKRPL--LPKPDPNSKRSNATCMNCSSTPTNKIL---SPPTTSNSPGAQVKLPNQTRSTGATKKKI 395


                 ...
gi 148232497 277 QTR 279
Cdd:COG5641  396 TRR 398
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
231-280 4.38e-09

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 57.57  E-value: 4.38e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 148232497 231 QCSNCHTSTTTLWRR---NASGDPV--CNACGLYYKLHNVNR-PLTMKKEGIQTRN 280
Cdd:COG5641  160 VCSNCKTTSTPLWRRassESSLPGNnlCNACGLYLKLHGSPRaPISLKSDSIKSRS 215
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
107-256 9.76e-09

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 56.80  E-value: 9.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148232497 107 YSASSFLLGSAPPAEregSPKFLETLKTERASPLTSDLLPLEPRSPSILQVGyIGGGGQEFS-----LFQSTEDRECVNC 181
Cdd:COG5641   89 HRASSRQSSISSLSD---FPISSSSSTSNAASPSTNYTDESNQQFSSYNTTL-NPGGTSSLNpnnnqSDNSNQPHVCSNC 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148232497 182 GATVTPLWRRD-----MSGHYLCNACGLYHKMNGQNRPLIRPKKRLIVSKRAGTQCSNC-HTSTTTLWRRNASGDPVCNA 255
Cdd:COG5641  165 KTTSTPLWRRAssessLPGNNLCNACGLYLKLHGSPRAPISLKSDSIKSRSSRSSHNNNdSNGENANTESIGNSSASKLT 244


                 .
gi 148232497 256 C 256
Cdd:COG5641  245 K 245
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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