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Conserved domains on  [gi|145332979|ref|NP_001078355|]
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Transducin family protein / WD-40 repeat family protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
53-209 2.67e-23

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.07  E-value: 2.67e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332979  53 RILAAACDDGCVRLYRISNLEKLtyyRSLPRVSGRALSVTWSPDAKRIFSGSSDGLIRCWDATSCHEVYRITAGLGGlgs 132
Cdd:COG2319  217 KLLASGSADGTVRLWDLATGKLL---RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG--- 290

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 145332979 133 sseicVWSL-LSLRCSVLVSGDSTGTVQFWDSEHGTLLEAHSNHKGDVNTLAAAPSHNRVFSAGADGQVILYKLSGST 209
Cdd:COG2319  291 -----VNSVaFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE 363
WD40 COG2319
WD40 repeat [General function prediction only];
408-552 1.85e-07

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.15  E-value: 1.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332979 408 WSVSRRRLPELPFAH-----SMIFSSDCSRLIIAGHDRRIYTIDISSLELVYAFTpsreEHEGeaptpkepPITKLFTSS 482
Cdd:COG2319  105 WDLATGLLLRTLTGHtgavrSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT----GHSG--------AVTSVAFSP 172

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145332979 483 DGQWLAAINCFGDIYVFNLETQRQhwfISRLDG--ASVTAAGFHPwNNNALVISTSSNQVFAFDVEARQLGK 552
Cdd:COG2319  173 DGKLLASGSDDGTVRLWDLATGKL---LRTLTGhtGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLR 240
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
53-209 2.67e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.07  E-value: 2.67e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332979  53 RILAAACDDGCVRLYRISNLEKLtyyRSLPRVSGRALSVTWSPDAKRIFSGSSDGLIRCWDATSCHEVYRITAGLGGlgs 132
Cdd:COG2319  217 KLLASGSADGTVRLWDLATGKLL---RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG--- 290

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 145332979 133 sseicVWSL-LSLRCSVLVSGDSTGTVQFWDSEHGTLLEAHSNHKGDVNTLAAAPSHNRVFSAGADGQVILYKLSGST 209
Cdd:COG2319  291 -----VNSVaFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE 363
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 52-204 4.11e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.16  E-value: 4.11e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332979  52 DRILAAACDDGCVRLYRISNLEKLtyyRSLPRVSGRALSVTWSPDAKRIFSGSSDGLIRCWDATSCHEVYRITAGLGGLG 131
Cdd:cd00200  147 GTFVASSSQDGTIKLWDLRTGKCV---ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVN 223

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 145332979 132 SsseiCVWSLLSLrcsVLVSGDSTGTVQFWDSEHGTLLEAHSNHKGDVNTLAAAPSHNRVFSAGADGQVILYK 204
Cdd:cd00200  224 S----VAFSPDGY---LLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
408-552 1.85e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.15  E-value: 1.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332979 408 WSVSRRRLPELPFAH-----SMIFSSDCSRLIIAGHDRRIYTIDISSLELVYAFTpsreEHEGeaptpkepPITKLFTSS 482
Cdd:COG2319  105 WDLATGLLLRTLTGHtgavrSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT----GHSG--------AVTSVAFSP 172

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145332979 483 DGQWLAAINCFGDIYVFNLETQRQhwfISRLDG--ASVTAAGFHPwNNNALVISTSSNQVFAFDVEARQLGK 552
Cdd:COG2319  173 DGKLLASGSDDGTVRLWDLATGKL---LRTLTGhtGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLR 240
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 79-113 4.52e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 4.52e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 145332979    79 RSLPRVSGRALSVTWSPDAKRIFSGSSDGLIRCWD 113
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 54-126 1.54e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 41.11  E-value: 1.54e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 145332979   54 ILAAACDDGCVRLYRISNleKLTYYRSLPRVSGRALSVTWSPDAKRIFSGSSDGLIRCWDATSCHEVYRITAG 126
Cdd:pfam12894   9 LIALATEDGELLLHRLNW--QRVWTLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAG 79
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
53-209 2.67e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.07  E-value: 2.67e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332979  53 RILAAACDDGCVRLYRISNLEKLtyyRSLPRVSGRALSVTWSPDAKRIFSGSSDGLIRCWDATSCHEVYRITAGLGGlgs 132
Cdd:COG2319  217 KLLASGSADGTVRLWDLATGKLL---RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG--- 290

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 145332979 133 sseicVWSL-LSLRCSVLVSGDSTGTVQFWDSEHGTLLEAHSNHKGDVNTLAAAPSHNRVFSAGADGQVILYKLSGST 209
Cdd:COG2319  291 -----VNSVaFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE 363
WD40 COG2319
WD40 repeat [General function prediction only];
53-207 3.76e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.30  E-value: 3.76e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332979  53 RILAAACDDGCVRLYRISNLEKLtyyRSLPRVSGRALSVTWSPDAKRIFSGSSDGLIRCWDATSCHEVYRITAGLGGlgs 132
Cdd:COG2319  259 RLLASGSADGTVRLWDLATGELL---RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA--- 332

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 145332979 133 sseicVWSL-LSLRCSVLVSGDSTGTVQFWDSEHGTLLEAHSNHKGDVNTLAAAPSHNRVFSAGADGQVILYKLSG 207
Cdd:COG2319  333 -----VRSVaFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
53-206 3.29e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.60  E-value: 3.29e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332979  53 RILAAACDDGCVRLYRISNLEKLtyyRSLPRVSGRALSVTWSPDAKRIFSGSSDGLIRCWDATSCHEVYRITAGLGGlgs 132
Cdd:COG2319  175 KLLASGSDDGTVRLWDLATGKLL---RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS--- 248

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145332979 133 sseicVWSL-LSLRCSVLVSGDSTGTVQFWDSEHGTLLEAHSNHKGDVNTLAAAPSHNRVFSAGADGQVILYKLS 206
Cdd:COG2319  249 -----VRSVaFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA 318
WD40 COG2319
WD40 repeat [General function prediction only];
52-207 2.71e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 90.74  E-value: 2.71e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332979  52 DRILAAACDDGCVRLYRISNLEKLtyyRSLPRVSGRALSVTWSPDAKRIFSGSSDGLIRCWDATSCHEVYRITAGLGGlg 131
Cdd:COG2319   90 GRLLASASADGTVRLWDLATGLLL---RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGA-- 164

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145332979 132 ssseicVWSL-LSLRCSVLVSGDSTGTVQFWDSEHGTLLEAHSNHKGDVNTLAAAPSHNRVFSAGADGQVILYKLSG 207
Cdd:COG2319  165 ------VTSVaFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT 235
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 52-204 4.11e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.16  E-value: 4.11e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332979  52 DRILAAACDDGCVRLYRISNLEKLtyyRSLPRVSGRALSVTWSPDAKRIFSGSSDGLIRCWDATSCHEVYRITAGLGGLG 131
Cdd:cd00200  147 GTFVASSSQDGTIKLWDLRTGKCV---ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVN 223

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 145332979 132 SsseiCVWSLLSLrcsVLVSGDSTGTVQFWDSEHGTLLEAHSNHKGDVNTLAAAPSHNRVFSAGADGQVILYK 204
Cdd:cd00200  224 S----VAFSPDGY---LLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 53-223 1.84e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.54  E-value: 1.84e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332979  53 RILAAACDDGCVRLYrisNLEKLTYYRSLPRVSGRALSVTWSPDAKRIFSGSSDGLIRCWDATSCHEVYRITAGLGG--- 129
Cdd:cd00200   22 KLLATGSGDGTIKVW---DLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYvss 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332979 130 ----------LGSSS--EICVWSLLSLRC------------SVLVSGDST--------GTVQFWDSEHGTLLEAHSNHKG 177
Cdd:cd00200   99 vafspdgrilSSSSRdkTIKVWDVETGKClttlrghtdwvnSVAFSPDGTfvasssqdGTIKLWDLRTGKCVATLTGHTG 178

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 145332979 178 DVNTLAAAPSHNRVFSAGADGQVILYKLS---------GSTNGSQDLKPSSSQKW 223
Cdd:cd00200  179 EVNSVAFSPDGEKLLSSSSDGTIKLWDLStgkclgtlrGHENGVNSVAFSPDGYL 233
WD40 COG2319
WD40 repeat [General function prediction only];
64-489 8.19e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.87  E-value: 8.19e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332979  64 VRLYRISNLEKLTYYRSLPRVSGRALSVTWSPDAKRIFSGSSDGLIRCWDATSCHEVYRITAGLGGlgssseicVWSL-L 142
Cdd:COG2319   57 DLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGA--------VRSVaF 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332979 143 SLRCSVLVSGDSTGTVQFWDSEHGTLLEAHSNHKGDVNTLAAAPSHNRVFSAGADGQVILYKLsgsTNGSQdlkpsssqk 222
Cdd:COG2319  129 SPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL---ATGKL--------- 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332979 223 wdyIGYVKAHTHDIRALTVAvpisredpfPDdilpdkasrkhrkkGKpvdftyhkwahlgvpMLISAGDDAKLFAYSI-- 300
Cdd:COG2319  197 ---LRTLTGHTGAVRSVAFS---------PD--------------GK---------------LLASGSADGTVRLWDLat 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332979 301 -QEFTKFSPHDicpapqripmQMVHNSMFNKTSLLLVqgistldilrlniSSDSSG-----RASTKSLVRVKSRDARKII 374
Cdd:COG2319  236 gKLLRTLTGHS----------GSVRSVAFSPDGRLLA-------------SGSADGtvrlwDLATGELLRTLTGHSGGVN 292

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332979 375 CSAISNTGSHFAYSDQIGpslfelkknefTKCPWSVSRRRLPELPFAH-----SMIFSSDCSRLIIAGHDRRIYTIDISS 449
Cdd:COG2319  293 SVAFSPDGKLLASGSDDG-----------TVRLWDLATGKLLRTLTGHtgavrSVAFSPDGKTLASGSDDGTVRLWDLAT 361

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 145332979 450 LELVYAFTpsreEHEGeaptpkepPITKLFTSSDGQWLAA 489
Cdd:COG2319  362 GELLRTLT----GHTG--------AVTSVAFSPDGRTLAS 389
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 52-205 2.42e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.13  E-value: 2.42e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332979  52 DRILAAACDDGCVRLYRISNLEKLTyyrSLPRVSGRALSVTWSPDAKRIFSGSSDGLIRCWDATSCHEVYRITAglgglg 131
Cdd:cd00200  105 GRILSSSSRDKTIKVWDVETGKCLT---TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTG------ 175

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145332979 132 ssSEICVWSL-LSLRCSVLVSGDSTGTVQFWDSEHGTLLEAHSNHKGDVNTLAAAPSHNRVFSAGADGQVILYKL 205
Cdd:cd00200  176 --HTGEVNSVaFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDL 248
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 85-205 7.37e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.51  E-value: 7.37e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332979  85 SGRALSVTWSPDAKRIFSGSSDGLIRCWDATSCHEVYRITAGLGGLGSsseiCVWSLLSLRcsvLVSGDSTGTVQFWDSE 164
Cdd:cd00200    9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRD----VAASADGTY---LASGSSDKTIRLWDLE 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 145332979 165 HGTLLEAHSNHKGDVNTLAAAPSHNRVFSAGADGQVILYKL 205
Cdd:cd00200   82 TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV 122
WD40 COG2319
WD40 repeat [General function prediction only];
52-116 5.18e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.77  E-value: 5.18e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145332979  52 DRILAAACDDGCVRLYRISNLEKLtyyRSLPRVSGRALSVTWSPDAKRIFSGSSDGLIRCWDATS 116
Cdd:COG2319  342 GKTLASGSDDGTVRLWDLATGELL---RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
408-552 1.85e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.15  E-value: 1.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145332979 408 WSVSRRRLPELPFAH-----SMIFSSDCSRLIIAGHDRRIYTIDISSLELVYAFTpsreEHEGeaptpkepPITKLFTSS 482
Cdd:COG2319  105 WDLATGLLLRTLTGHtgavrSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT----GHSG--------AVTSVAFSP 172

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145332979 483 DGQWLAAINCFGDIYVFNLETQRQhwfISRLDG--ASVTAAGFHPwNNNALVISTSSNQVFAFDVEARQLGK 552
Cdd:COG2319  173 DGKLLASGSDDGTVRLWDLATGKL---LRTLTGhtGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLR 240
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 79-113 4.52e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 4.52e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 145332979    79 RSLPRVSGRALSVTWSPDAKRIFSGSSDGLIRCWD 113
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 54-126 1.54e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 41.11  E-value: 1.54e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 145332979   54 ILAAACDDGCVRLYRISNleKLTYYRSLPRVSGRALSVTWSPDAKRIFSGSSDGLIRCWDATSCHEVYRITAG 126
Cdd:pfam12894   9 LIALATEDGELLLHRLNW--QRVWTLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAG 79
WD40 pfam00400
WD domain, G-beta repeat;
90-113 1.99e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 1.99e-03
                          10        20
                  ....*....|....*....|....
gi 145332979   90 SVTWSPDAKRIFSGSSDGLIRCWD 113
Cdd:pfam00400  16 SLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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