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Conserved domains on  [gi|139948179|ref|NP_001077278|]
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large neutral amino acids transporter small subunit 3 isoform 3 [Mus musculus]

Protein Classification

sugar MFS transporter( domain architecture ID 1905563)

sugar major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of sugar substrates including glucose, galactose, mannose and fucose

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FucP super family cl43255
Fucose permease [Carbohydrate transport and metabolism];
101-255 5.87e-05

Fucose permease [Carbohydrate transport and metabolism];


The actual alignment was detected with superfamily member COG0738:

Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 45.62  E-value: 5.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139948179 101 MLNLGFTIGSFLLSattLPLGILMDRFGPRPLRLVGSACFAASCTLMALASRdtevlSPLIFLALSLNGFaGICLTFTSL 180
Cdd:COG0738   47 LLLFAFFLGYLLAS---LPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPS-----YPLLLLALFLLGL-GLGLLDVAA 117

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 139948179 181 T--LPNMFGNLRSTFMALMIGSYASSAITFPGI-KLIYDAGVPFTVIMFTWsGLACLIFLNCALNWPAeAFPAPEEVD 255
Cdd:COG0738  118 NpyVAALGPETAASRLNLLHAFFSLGALLGPLLgGLLILLGLSLSWHLPYL-ILAVLLLLLALLFLRS-KLPEIEEEE 193
 
Name Accession Description Interval E-value
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
101-255 5.87e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 45.62  E-value: 5.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139948179 101 MLNLGFTIGSFLLSattLPLGILMDRFGPRPLRLVGSACFAASCTLMALASRdtevlSPLIFLALSLNGFaGICLTFTSL 180
Cdd:COG0738   47 LLLFAFFLGYLLAS---LPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPS-----YPLLLLALFLLGL-GLGLLDVAA 117

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 139948179 181 T--LPNMFGNLRSTFMALMIGSYASSAITFPGI-KLIYDAGVPFTVIMFTWsGLACLIFLNCALNWPAeAFPAPEEVD 255
Cdd:COG0738  118 NpyVAALGPETAASRLNLLHAFFSLGALLGPLLgGLLILLGLSLSWHLPYL-ILAVLLLLLALLFLRS-KLPEIEEEE 193
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 101-267 1.63e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 44.34  E-value: 1.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139948179 101 MLNLGFTIGSFLLSATTLPLGILMDRFGPRPLRLVGSACFAASCTLMALAsrdteVLSPLIFLALSLNGFAGICLTFTSL 180
Cdd:cd06174   32 QLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA-----PSFWLLLLGRFLLGLGSGLIDPAVL 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139948179 181 TL------PNMFGNLRSTFMALMIGSYASSAITFPGIKLIYDAGVP-FTVIMFTWSGLACLIFLNCALNWPAEAFPAPEE 253
Cdd:cd06174  107 ALiadlfpERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRaVFLIAAALALLAAILLLLVVPDPPESARAKNEE 186

                        170
                 ....*....|....
gi 139948179 254 VDYTKKIKLIGLAL 267
Cdd:cd06174  187 ASSKSVLKLLKRVL 200
MFS_1 pfam07690
Major Facilitator Superfamily;
101-241 1.72e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 43.95  E-value: 1.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139948179  101 MLNLGFTIGSFLLSATTLPLGILMDRFGPRPLRLVGSACFAASCTLMALASRDTEVLSPLIFLALSLNGFAGICLTFTSL 180
Cdd:pfam07690  33 EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIAD 112

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 139948179  181 TLPnmfGNLRSTFMALMIGSYASSAITFPGIKLIYDAGVPFTVIMFTWSGLACLIFLNCAL 241
Cdd:pfam07690 113 WFP---PEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLL 170
2A0108 TIGR00886
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
 118-240 6.73e-03

nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]


Pssm-ID: 273322 [Multi-domain]  Cd Length: 354  Bit Score: 39.21  E-value: 6.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139948179  118 LPLGILMDRFGPRPLRLVGSACFAASCTLMALASRDTEVLSPLIFLAlslnGFAG----ICLTFTSLTLPNM-------- 185
Cdd:TIGR00886  55 IILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVQSYSVLLLIRLFI----GIAGgsfaSCMPWISFFFPKKiqgtalgl 130

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 139948179  186 ---FGNLRSTFMALMIGSYASSAITFPGIKLIYDAGVPFTVIMFTWSGL-ACLIFLNCA 240
Cdd:TIGR00886 131 aagWGNMGGGVAQFVMPPIIGSLIFGGGQPAHLAWGWAFVIVPAGILLLpALLIFFVGA 189
 
Name Accession Description Interval E-value
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
101-255 5.87e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 45.62  E-value: 5.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139948179 101 MLNLGFTIGSFLLSattLPLGILMDRFGPRPLRLVGSACFAASCTLMALASRdtevlSPLIFLALSLNGFaGICLTFTSL 180
Cdd:COG0738   47 LLLFAFFLGYLLAS---LPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPS-----YPLLLLALFLLGL-GLGLLDVAA 117

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 139948179 181 T--LPNMFGNLRSTFMALMIGSYASSAITFPGI-KLIYDAGVPFTVIMFTWsGLACLIFLNCALNWPAeAFPAPEEVD 255
Cdd:COG0738  118 NpyVAALGPETAASRLNLLHAFFSLGALLGPLLgGLLILLGLSLSWHLPYL-ILAVLLLLLALLFLRS-KLPEIEEEE 193
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
104-237 7.44e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 45.26  E-value: 7.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139948179 104 LGFTIGSFLLSATTLPLGILMDRFGPRPLRLVGSACFAASCTLMALASrdtevlSPLIFLALSLNGFAGICLTFTS--LT 181
Cdd:COG2223   44 LLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAV------SYWLLLLLGLLLGIGGGGSFAVgiAL 117

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 139948179 182 LPNMF-GNLRSTFMALMIGSY--ASSAITFPGIKLIYDAGVPFTviMFTWSGLACLIFL 237
Cdd:COG2223  118 VSKWFpPDRRGLALGLAAGGGnlGAAVAAFLAPLLIAAFGWRNA--FLILGILLLVVAV 174
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 101-267 1.63e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 44.34  E-value: 1.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139948179 101 MLNLGFTIGSFLLSATTLPLGILMDRFGPRPLRLVGSACFAASCTLMALAsrdteVLSPLIFLALSLNGFAGICLTFTSL 180
Cdd:cd06174   32 QLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA-----PSFWLLLLGRFLLGLGSGLIDPAVL 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139948179 181 TL------PNMFGNLRSTFMALMIGSYASSAITFPGIKLIYDAGVP-FTVIMFTWSGLACLIFLNCALNWPAEAFPAPEE 253
Cdd:cd06174  107 ALiadlfpERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRaVFLIAAALALLAAILLLLVVPDPPESARAKNEE 186

                        170
                 ....*....|....
gi 139948179 254 VDYTKKIKLIGLAL 267
Cdd:cd06174  187 ASSKSVLKLLKRVL 200
MFS_1 pfam07690
Major Facilitator Superfamily;
101-241 1.72e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 43.95  E-value: 1.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139948179  101 MLNLGFTIGSFLLSATTLPLGILMDRFGPRPLRLVGSACFAASCTLMALASRDTEVLSPLIFLALSLNGFAGICLTFTSL 180
Cdd:pfam07690  33 EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIAD 112

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 139948179  181 TLPnmfGNLRSTFMALMIGSYASSAITFPGIKLIYDAGVPFTVIMFTWSGLACLIFLNCAL 241
Cdd:pfam07690 113 WFP---PEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLL 170
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 101-237 2.16e-04

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 43.73  E-value: 2.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139948179 101 MLNLGFTIGSFLLsattlplGILMDRFGPRPLRLVGSACFAASCTLMALASRDTEVLSPLIFLalslngfAGICLTFTSL 180
Cdd:cd17365  214 LLNIGGVIGSLLL-------GWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFL-------AGACVNGAQV 279

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 139948179 181 TLPNMFGNL-----RSTFMALMIGSYASSAITFPGI-KLIYDAGVPFTVIMFTWSGLACLIFL 237
Cdd:cd17365  280 GLYALAARFyptevRATGVGWALGVGRLGAILGPLLgGLLLAAGLGPESVFLALAIPAALGAL 342
MFS_Mch1p_like cd17354
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ...
 96-267 3.27e-04

Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340912 [Multi-domain]  Cd Length: 385  Bit Score: 43.39  E-value: 3.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139948179  96 DQQEKMLnlgFTIGSFLLSATTLPLGILMDRFGPRPLRLVGSACFAASCTLMALA-SRDTEVLS-PLIFLALSLNGFAGI 173
Cdd:cd17354   36 SQQQNNL---LSVAKDLGYLVGPLLGLLSDRLGPWLLLLIGAILFFPGYGVLWLVvTGLISDLSfWLMCLCFFLIGNSTS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139948179 174 CLTFTSLTLPN-MFGNLRSTFMALMIGSYA-SSAITFPGIKLIYDAGVPFTVIMFTWsglacLIFLNCALNWPAEAFPAP 251
Cdd:cd17354  113 SLYTAALVTCAkNFPESRGLAIGIPKGCYGlSGAIGSQLYKALFFHDSARVFLFLAV-----LPAVVGLLAWFSVRIVSI 187

                        170
                 ....*....|....*.
gi 139948179 252 EEVDYTKKIKLIGLAL 267
Cdd:cd17354  188 EEGEFLKDIDFWLLFI 203
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
104-237 4.24e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 42.93  E-value: 4.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139948179 104 LGFTIGSFLLSATTLPLGILMDRFGPRPLRLVGSACFAASCTLMALASrdtevlSPLIFLAL-SLNGFA-GICLTFTSLT 181
Cdd:COG2271   49 LLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFAT------SFWQLLLLrFLLGLGeAGFFPAALKL 122

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 139948179 182 LPNMF-GNLRSTFMAL-MIGSYASSAITFP-GIKLIYDAGVPftvIMFTWSGLACLIFL 237
Cdd:COG2271  123 IAEWFpPKERGRALGIfNAGGPLGGALAPPlLGWLLAAFGWR---AAFLILGLPGLLLA 178
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 104-151 4.42e-04

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 43.03  E-value: 4.42e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 139948179 104 LGFTIGsFLLSATTLPL-GILMDRFGPRPLRLVGSACFAASCTLMALAS 151
Cdd:cd17355   42 LAFTVG-LLAFGLAQPFvGRLLDRFGPRRVMLLGLLLLAAGLVLLALAT 89
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 93-173 5.23e-04

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 42.60  E-value: 5.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139948179  93 TSCDQQEKMLNLGFTIGSFLLSATTLPLGILMDRFGPRPLRLVGSACFAASCTLMALASRdtevlSPLIFLALSlnGFAG 172
Cdd:cd17353   31 SALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAIS-----LPLLFLGYG--VLGG 103


                 .
gi 139948179 173 I 173
Cdd:cd17353  104 I 104
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 102-211 6.38e-04

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 42.31  E-value: 6.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139948179 102 LNLGFTIGSFLLsattlplGILMDRFGPRPLRLVGSACFAASCTLMALASrdtevLSPLIFLALSLNGFA-GICLTFTSL 180
Cdd:cd17333   40 QNAGYLIGSLLA-------GFLMKRLGRRRTLILGLLLISLALALIFATP-----SIYLFVVLMFLAGLGaGILDTGANT 107

                         90       100       110
                 ....*....|....*....|....*....|.
gi 139948179 181 TLPNMFGNLRSTFMALMIGSYASSAITFPGI 211
Cdd:cd17333  108 FVGALFEESSATRLNVLHGFFGLGALIGPLI 138
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 108-181 7.47e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 42.18  E-value: 7.47e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 139948179 108 IGSFLLSattlPL-GILMDRFGPRPLRLVGSACFAASCTLMALASRDTEVlsPLIFLALSLNGFaGICLTFTSLT 181
Cdd:cd17503  225 LASAILS----PLvGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSL--WLIILPLFIRGL-GMGLVFMPLN 292
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
104-201 7.69e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 41.88  E-value: 7.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139948179 104 LGFTIGSFLLSATTLPLGILMDRFGPRPLRLVGSACFAASCTLMALASRDTEVLSPLIFLALSLNGFAGICLTFTSLTLP 183
Cdd:COG2814  247 LLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAP 326

                         90
                 ....*....|....*...
gi 139948179 184 nmfGNLRSTFMALMIGSY 201
Cdd:COG2814  327 ---PEARGRASGLYNSAF 341
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 101-208 1.12e-03

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 41.45  E-value: 1.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139948179 101 MLNLGFTIGSfllsattLPLGILMDRFGPRPLRLVGSACFAASCTLMALASRDTEVLSPLIFLAL--------------- 165
Cdd:cd17475   39 ALNLGVAVSM-------LPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAgygsvqpgggraimr 111

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 139948179 166 ----SLNGFA-GICLT-------FTSLTLPNMFG--NLRSTFMALMIGSYASSAITF 208
Cdd:cd17475  112 wfppRERGLAmGIRQTgvplggaLAAALLPPLALhyGWRAAFVVAGLVSILAAVLFW 168
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 104-181 1.14e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 41.39  E-value: 1.14e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 139948179 104 LGFTIGSFLLSATTlplGILMDRFGPRPLRLVGSACFAASCTLMALASRDTEVlsPLIFLALSLNGFaGICLTFTSLT 181
Cdd:cd17321  211 LPLALAMLVAAPLA---GRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSV--WLLLPGLVLLGL-GLGLFATPLT 282
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
104-211 1.35e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 41.11  E-value: 1.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139948179 104 LGFTIGSFLLSA--TTLPLGILMDRFGPRPLRLVGSACFAASCTLMALASRDTEVLSPLIFLALSLNGFAGICLTFTSLT 181
Cdd:COG2814   47 AGLVVTAYLLGAalGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADL 126

                         90       100       110
                 ....*....|....*....|....*....|
gi 139948179 182 LPnmfGNLRSTFMALMIGSYASSAITFPGI 211
Cdd:COG2814  127 VP---PERRGRALGLLGAGLGLGPALGPLL 153
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 104-199 3.53e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 39.84  E-value: 3.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139948179 104 LGFTIGSFLLSATTLPLGILMDRFGPRPLRLVGSACFAASCTLMALASRDTEVLSPLIFLALSLNGFAGICLTFTSLTLP 183
Cdd:cd17324   38 LLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVP 117

                         90
                 ....*....|....*.
gi 139948179 184 nmfGNLRSTFMALMIG 199
Cdd:cd17324  118 ---PEKRGRAIGLVFS 130
MFS_1 pfam07690
Major Facilitator Superfamily;
106-209 3.73e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 39.71  E-value: 3.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139948179  106 FTIGSFLLSATTLPLGILMDRFGPRPLRLVGSACFAASCTLMALASRDTEVLSPLIFLALSLNGFAGICLTFTSLTLPNM 185
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320

                          90       100
                  ....*....|....*....|....
gi 139948179  186 FGNLRSTFMALMIGSYASSAITFP 209
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGALGP 344
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 105-241 5.04e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 39.50  E-value: 5.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139948179 105 GFTIGSFLLSA--TTLPLGILMDRFGPRPLRLVGSACFAASCTLMALASrdtevlSPLIFLALSL-NGFA-GICLTFTSL 180
Cdd:cd17489   34 GLVVGLFTLAAllARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT------SVALLLVLRLiHGIGwGAFTTAAAT 107

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 139948179 181 TLPNMFGN-LRSTFMALM-IGSYASSAItFPGIKLIYDAGVPFTVIMFTWSGLACLIFLNCAL 241
Cdd:cd17489  108 LVADIIPPsRRGEGIGYYgLATTLAMAL-GPALGLFLYQHLGFAVLFIVAAVLALLALLLVFL 169
2A0108 TIGR00886
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
 118-240 6.73e-03

nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]


Pssm-ID: 273322 [Multi-domain]  Cd Length: 354  Bit Score: 39.21  E-value: 6.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139948179  118 LPLGILMDRFGPRPLRLVGSACFAASCTLMALASRDTEVLSPLIFLAlslnGFAG----ICLTFTSLTLPNM-------- 185
Cdd:TIGR00886  55 IILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVQSYSVLLLIRLFI----GIAGgsfaSCMPWISFFFPKKiqgtalgl 130

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 139948179  186 ---FGNLRSTFMALMIGSYASSAITFPGIKLIYDAGVPFTVIMFTWSGL-ACLIFLNCA 240
Cdd:TIGR00886 131 aagWGNMGGGVAQFVMPPIIGSLIFGGGQPAHLAWGWAFVIVPAGILLLpALLIFFVGA 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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