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Conserved domains on  [gi|126722743|ref|NP_001075949|]
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zinc finger protein 623 isoform 2 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
83-454 3.18e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.57  E-value: 3.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722743  83 NPCDICGKTFTFNSDLVRHRISHAGEKPYTC--DQCGKGFGQSSHLMEHQRIHTGERLYVCNVCGKD--FIHYSGLIEHQ 158
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722743 159 RVHSgekPFKCAQCGKAFCHSSDLIRHQRVHTRERPFECKE-------------------------CGKGFSQSSLLIRH 213
Cdd:COG5048  114 SSNS---NDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLpgnnsssvntpqsnslhpplpanslSKDPSSNLSLLISS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722743 214 QRIHTGERPYECNECGKSFIRSSSLIRHYQIHTEVKqYECKECGKAFRHRSDLIEHQRIHTGERPFECNECGKAF--IRS 291
Cdd:COG5048  191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSS-LPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSlpTAS 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722743 292 SKLIQHQRIHTGER-----PYVCNECGKRFSQTSNFTQHQR--IHTGEKLYECNE----CGKAFFLSSYLIRHQKIHTGE 360
Cdd:COG5048  270 SQSSSPNESDSSSEkgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFSCpyslCGKLFSRNDALKRHILLHTSI 349

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722743 361 RVYECK--ECGKAFLQKAH-----LTEHQKIHSGDRPFEC--KDCGKAFIQSSKLLLHQIIHTGEKPYVC--SYCGKGFI 429
Cdd:COG5048  350 SPAKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFN 429

                        410       420
                 ....*....|....*....|....*
gi 126722743 430 QRSNFLQHQKIHTEEKLYECSQYGR 454
Cdd:COG5048  430 RHYNLIPHKKIHTNHAPLLCSILKS 454
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
83-454 3.18e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.57  E-value: 3.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722743  83 NPCDICGKTFTFNSDLVRHRISHAGEKPYTC--DQCGKGFGQSSHLMEHQRIHTGERLYVCNVCGKD--FIHYSGLIEHQ 158
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722743 159 RVHSgekPFKCAQCGKAFCHSSDLIRHQRVHTRERPFECKE-------------------------CGKGFSQSSLLIRH 213
Cdd:COG5048  114 SSNS---NDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLpgnnsssvntpqsnslhpplpanslSKDPSSNLSLLISS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722743 214 QRIHTGERPYECNECGKSFIRSSSLIRHYQIHTEVKqYECKECGKAFRHRSDLIEHQRIHTGERPFECNECGKAF--IRS 291
Cdd:COG5048  191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSS-LPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSlpTAS 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722743 292 SKLIQHQRIHTGER-----PYVCNECGKRFSQTSNFTQHQR--IHTGEKLYECNE----CGKAFFLSSYLIRHQKIHTGE 360
Cdd:COG5048  270 SQSSSPNESDSSSEkgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFSCpyslCGKLFSRNDALKRHILLHTSI 349

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722743 361 RVYECK--ECGKAFLQKAH-----LTEHQKIHSGDRPFEC--KDCGKAFIQSSKLLLHQIIHTGEKPYVC--SYCGKGFI 429
Cdd:COG5048  350 SPAKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFN 429

                        410       420
                 ....*....|....*....|....*
gi 126722743 430 QRSNFLQHQKIHTEEKLYECSQYGR 454
Cdd:COG5048  430 RHYNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
210-234 2.38e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.38e-04
                          10        20
                  ....*....|....*....|....*
gi 126722743  210 LIRHQRIHTGERPYECNECGKSFIR 234
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
83-454 3.18e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.57  E-value: 3.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722743  83 NPCDICGKTFTFNSDLVRHRISHAGEKPYTC--DQCGKGFGQSSHLMEHQRIHTGERLYVCNVCGKD--FIHYSGLIEHQ 158
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722743 159 RVHSgekPFKCAQCGKAFCHSSDLIRHQRVHTRERPFECKE-------------------------CGKGFSQSSLLIRH 213
Cdd:COG5048  114 SSNS---NDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLpgnnsssvntpqsnslhpplpanslSKDPSSNLSLLISS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722743 214 QRIHTGERPYECNECGKSFIRSSSLIRHYQIHTEVKqYECKECGKAFRHRSDLIEHQRIHTGERPFECNECGKAF--IRS 291
Cdd:COG5048  191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSS-LPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSlpTAS 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722743 292 SKLIQHQRIHTGER-----PYVCNECGKRFSQTSNFTQHQR--IHTGEKLYECNE----CGKAFFLSSYLIRHQKIHTGE 360
Cdd:COG5048  270 SQSSSPNESDSSSEkgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFSCpyslCGKLFSRNDALKRHILLHTSI 349

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722743 361 RVYECK--ECGKAFLQKAH-----LTEHQKIHSGDRPFEC--KDCGKAFIQSSKLLLHQIIHTGEKPYVC--SYCGKGFI 429
Cdd:COG5048  350 SPAKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFN 429

                        410       420
                 ....*....|....*....|....*
gi 126722743 430 QRSNFLQHQKIHTEEKLYECSQYGR 454
Cdd:COG5048  430 RHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
86-292 7.20e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 7.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722743  86 DICGKTFTFNSDLVRHRISHagekpYTCDQCGKGFGQSSHLMEHQRIHTGERL-YVCNVCGKDFIHYSGLIEHQR--VHS 162
Cdd:COG5048  241 LSQSPSSLSSSDSSSSASES-----PRSSLPTASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRsvNHS 315

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722743 163 GE--KPFKC--AQCGKAFCHSSDLIRHQRVHTRERPFECKECGKGFSQSSLL-------IRHQRIHTGERPYEC--NECG 229
Cdd:COG5048  316 GEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETlsNSCI 395

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 126722743 230 KSFIRSSSLIRHYQIHTEVKQYECK--ECGKAFRHRSDLIEHQRIHTGERPFECNECGKAFIRSS 292
Cdd:COG5048  396 RNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
165-442 2.06e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 2.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722743 165 KPFKCAQCGKAFCHSSDLIRHQRVHTRERPFEC--KECGKGFSQSSLLIRHQRIHTGERPYECNECG---KSFIRSSSLI 239
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722743 240 RHYQIHTEVKQYECKECGKAFRHRSDLIEHQRIHTGERPFE-CNECGKAFIRSSKLIQ-------------------HQR 299
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPgNNSSSVNTPQSNSLHPplpanslskdpssnlslliSSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126722743 300 IHTGERPYVCNECGKRFSQTSNFTQHQRIHTGEKLYECNECGKAFFLSSYLIRHQKIHTGERVYECKECGKAFLQKAHLT 379
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 126722743 380 EHQKIHSG-------DRPFECKDCGKAFIQSSKLLLHQ--IIHTGE--KPYVC--SYCGKGFIQRSNFLQHQKIHT 442
Cdd:COG5048  272 SSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347
zf-H2C2_2 pfam13465
Zinc-finger double domain;
210-234 2.38e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.38e-04
                          10        20
                  ....*....|....*....|....*
gi 126722743  210 LIRHQRIHTGERPYECNECGKSFIR 234
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
294-318 6.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.95e-04
                          10        20
                  ....*....|....*....|....*
gi 126722743  294 LIQHQRIHTGERPYVCNECGKRFSQ 318
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
265-290 7.97e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.97e-04
                          10        20
                  ....*....|....*....|....*.
gi 126722743  265 DLIEHQRIHTGERPFECNECGKAFIR 290
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
349-374 1.54e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.54e-03
                          10        20
                  ....*....|....*....|....*.
gi 126722743  349 YLIRHQKIHTGERVYECKECGKAFLQ 374
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
377-402 2.77e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.77e-03
                          10        20
                  ....*....|....*....|....*.
gi 126722743  377 HLTEHQKIHSGDRPFECKDCGKAFIQ 402
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
181-206 2.91e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.91e-03
                          10        20
                  ....*....|....*....|....*.
gi 126722743  181 DLIRHQRVHTRERPFECKECGKGFSQ 206
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
388-461 3.23e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 3.23e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 126722743 388 DRPFECKDCGKAFIQSSKLLLHQIIHTGEKPYVCSY--CGKGFIQRSNFLQHQKIHTEEKLYECSQYGRDFNSTTN 461
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKAS 106
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 195-217 3.26e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 3.26e-03
                          10        20
                  ....*....|....*....|...
gi 126722743  195 FECKECGKGFSQSSLLIRHQRIH 217
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 251-273 3.75e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 3.75e-03
                          10        20
                  ....*....|....*....|...
gi 126722743  251 YECKECGKAFRHRSDLIEHQRIH 273
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
154-176 4.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.53e-03
                          10        20
                  ....*....|....*....|...
gi 126722743  154 LIEHQRVHSGEKPFKCAQCGKAF 176
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 223-245 4.88e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.88e-03
                          10        20
                  ....*....|....*....|...
gi 126722743  223 YECNECGKSFIRSSSLIRHYQIH 245
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 167-189 6.18e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 6.18e-03
                          10        20
                  ....*....|....*....|...
gi 126722743  167 FKCAQCGKAFCHSSDLIRHQRVH 189
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
125-150 6.27e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.27e-03
                          10        20
                  ....*....|....*....|....*.
gi 126722743  125 HLMEHQRIHTGERLYVCNVCGKDFIH 150
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
321-344 7.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.12e-03
                          10        20
                  ....*....|....*....|....
gi 126722743  321 NFTQHQRIHTGEKLYECNECGKAF 344
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 307-329 7.37e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 7.37e-03
                          10        20
                  ....*....|....*....|...
gi 126722743  307 YVCNECGKRFSQTSNFTQHQRIH 329
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 279-301 8.71e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 8.71e-03
                          10        20
                  ....*....|....*....|...
gi 126722743  279 FECNECGKAFIRSSKLIQHQRIH 301
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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