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Conserved domains on  [gi|126012533|ref|NP_001075105|]
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G1/S-specific cyclin-D3 [Mus musculus]

Protein Classification

cyclin family protein( domain architecture ID 1750054)

cyclin family protein may associate with and activate its cognate cyclin-dependent kinase (CDK)

CATH:  1.10.472.10
Gene Ontology:  GO:0000079|GO:0019901|GO:0007049
PubMed:  14744433|30185601|15269391|15840440
SCOP:  4001102

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_SF super family cl40454
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 2-151 3.70e-107

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


The actual alignment was detected with superfamily member cd20575:

Pssm-ID: 477360  Cd Length: 150  Bit Score: 307.69  E-value: 3.70e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533   2 ELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQKEIKPHMRKMLAYWMLEVCEEQRCEEDVFPLA 81
Cdd:cd20575    1 ELLCCEGTRRVPRAGPDPRLLGDQRVLQNLLRLEERYVPRVSYFQCVQREIKPYMRKMLAYWMLEVCEEQKCEEEVFPLA 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533  82 MNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLGKLKWD 151
Cdd:cd20575   81 MNYVDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDNSISPRQLLDWEILVLGKLKWD 150
CYCLIN_SF super family cl40454
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 156-260 2.11e-68

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


The actual alignment was detected with superfamily member cd20578:

Pssm-ID: 477360  Cd Length: 105  Bit Score: 207.61  E-value: 2.11e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533 156 IAHDFLALILHRLSLPSDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVLGLGACSMSADELTELLAGITGT 235
Cdd:cd20578    1 IAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGT 80

                         90       100
                 ....*....|....*....|....*
gi 126012533 236 EVDCLRACQEQIEAALRESLREAAQ 260
Cdd:cd20578   81 EVDCLRACQEQIEAALRESLREASQ 105
 
Name Accession Description Interval E-value
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 2-151 3.70e-107

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 307.69  E-value: 3.70e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533   2 ELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQKEIKPHMRKMLAYWMLEVCEEQRCEEDVFPLA 81
Cdd:cd20575    1 ELLCCEGTRRVPRAGPDPRLLGDQRVLQNLLRLEERYVPRVSYFQCVQREIKPYMRKMLAYWMLEVCEEQKCEEEVFPLA 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533  82 MNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLGKLKWD 151
Cdd:cd20575   81 MNYVDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDNSISPRQLLDWEILVLGKLKWD 150
CYCLIN_CCND3_rpt2 cd20578
second cyclin box found in G1/S-specific cyclin-D3 (CCND3); CCND3 is a regulatory component of ...
 156-260 2.11e-68

second cyclin box found in G1/S-specific cyclin-D3 (CCND3); CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410281  Cd Length: 105  Bit Score: 207.61  E-value: 2.11e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533 156 IAHDFLALILHRLSLPSDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVLGLGACSMSADELTELLAGITGT 235
Cdd:cd20578    1 IAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGT 80

                         90       100
                 ....*....|....*....|....*
gi 126012533 236 EVDCLRACQEQIEAALRESLREAAQ 260
Cdd:cd20578   81 EVDCLRACQEQIEAALRESLREASQ 105
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 26-153 6.80e-44

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 145.74  E-value: 6.80e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533   26 RVLQSLLRLEERYVPRASYFqCVQKEIKPHMRKMLAYWMLEVCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTV 105
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYM-DQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVT 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 126012533  106 CLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLGKLKWDLA 153
Cdd:pfam00134  80 CLFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 155-251 4.08e-15

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 69.96  E-value: 4.08e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533  155 VIAHDFLALILHRLSLPSDRQalVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVLGLGACsmsadELTELLAGITG 234
Cdd:pfam02984   1 PTPLSFLRRFSKAADYLHDLE--LRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLNSP-----EWTETLEHYTG 73

                          90
                  ....*....|....*..
gi 126012533  235 TEVDCLRACQEQIEAAL 251
Cdd:pfam02984  74 YSEEDLKPCVKLLLELL 90
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
31-207 1.39e-13

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 70.57  E-value: 1.39e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533  31 LLRLEERYVPRASYFQcVQKEIKPHMRKMLAYWMLEVCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLA 110
Cdd:COG5024  188 LLKLELIDLPNPNYLI-KQSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEKYQLVGISALFIA 266

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533 111 SKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLGKLKWDLAAVIAHDFlaliLHRLSLPSDRQALVKKHAQTFLALCA 190
Cdd:COG5024  267 SKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSF----LRRISKASDYDIFSRTPAKFSSEISP 342

                        170
                 ....*....|....*..
gi 126012533 191 TDYTFAMYPPSMIATGS 207
Cdd:COG5024  343 VDYKFIQISPSWCAAAA 359
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 63-145 2.13e-13

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 64.54  E-value: 2.13e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533    63 WMLEVCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVApwQLREWEV 142
Cdd:smart00385   2 FLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGYFTEE--EILRMER 79


                   ...
gi 126012533   143 LVL 145
Cdd:smart00385  80 LLL 82
 
Name Accession Description Interval E-value
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 2-151 3.70e-107

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 307.69  E-value: 3.70e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533   2 ELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQKEIKPHMRKMLAYWMLEVCEEQRCEEDVFPLA 81
Cdd:cd20575    1 ELLCCEGTRRVPRAGPDPRLLGDQRVLQNLLRLEERYVPRVSYFQCVQREIKPYMRKMLAYWMLEVCEEQKCEEEVFPLA 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533  82 MNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLGKLKWD 151
Cdd:cd20575   81 MNYVDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDNSISPRQLLDWEILVLGKLKWD 150
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 3-151 3.39e-90

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 264.55  E-value: 3.39e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533   3 LLCCEGTRHAPRAGP-DPRLLGDQRVLQSLLRLEERYVPRASYFQCVQKEIKPHMRKMLAYWMLEVCEEQRCEEDVFPLA 81
Cdd:cd20515    1 LLCCEVDTERRAYRDrSPALLLDDRVLQNLLSLEERYLPSASYFKCVQTEIQPFMRKMVTTWMLEVCEEQNCEEEVFPLA 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533  82 MNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLGKLKWD 151
Cdd:cd20515   81 VNYLDRFLSLVPIRKSQLQLLGAVCLFLASKLKETIPLTAEKLCIYTDNSITLQELLDWELLVLTKLKWD 150
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 1-151 1.14e-81

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 242.98  E-value: 1.14e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533   1 MELLCCEGTRhAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQKEIKPHMRKMLAYWMLEVCEEQRCEEDVFPL 80
Cdd:cd20574    1 MELLCCEVDT-IRRALPDPNLLYDDRVLQNLLTIEERYLPQCSYFKCVQKDIQPFMRRMVATWMLEVCEEQKCEEEVFPL 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 126012533  81 AMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLGKLKWD 151
Cdd:cd20574   80 AMNYLDRFLAVVPTRKCHLQLLGAVCMFLASKLKETIPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKWN 150
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 1-151 3.01e-70

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 214.07  E-value: 3.01e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533   1 MELLCCEgTRHAPRAGPDPRLLGDqRVLQSLLRLEERYVPRASYFQCVQKEIKPHMRKMLAYWMLEVCEEQRCEEDVFPL 80
Cdd:cd20573    1 HQLLCCE-VETIRRAYLDANLLND-RVLQTMLKAEETCLPSVSYFKCVQKEILPSMRKIVATWMLEVCEEQKCEEEVFPL 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 126012533  81 AMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLGKLKWD 151
Cdd:cd20573   79 AMNYLDRFLSVEPTKKSRLQLLGATCMFLASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLVLNKLKWD 149
CYCLIN_CCND3_rpt2 cd20578
second cyclin box found in G1/S-specific cyclin-D3 (CCND3); CCND3 is a regulatory component of ...
 156-260 2.11e-68

second cyclin box found in G1/S-specific cyclin-D3 (CCND3); CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410281  Cd Length: 105  Bit Score: 207.61  E-value: 2.11e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533 156 IAHDFLALILHRLSLPSDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVLGLGACSMSADELTELLAGITGT 235
Cdd:cd20578    1 IAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGT 80

                         90       100
                 ....*....|....*....|....*
gi 126012533 236 EVDCLRACQEQIEAALRESLREAAQ 260
Cdd:cd20578   81 EVDCLRACQEQIEAALRESLREASQ 105
CYCLIN_CCND2_rpt2 cd20577
second cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 158-256 8.52e-47

second cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410280  Cd Length: 105  Bit Score: 152.69  E-value: 8.52e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533 158 HDFLALILHRLSLPSDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVLGL----GACSMSADELTELLAGIT 233
Cdd:cd20577    3 HDFIEHILRKLPLPKDKLPLIRKHAQTFIALCATDFKFAMYPPSMIATGSVGAAICGLqldrGDSSLSGDSLTELLAKIT 82

                         90       100
                 ....*....|....*....|...
gi 126012533 234 GTEVDCLRACQEQIEAALRESLR 256
Cdd:cd20577   83 NTDVDCLKACQEQIESVLVSNLR 105
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 26-153 6.80e-44

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 145.74  E-value: 6.80e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533   26 RVLQSLLRLEERYVPRASYFqCVQKEIKPHMRKMLAYWMLEVCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTV 105
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYM-DQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVT 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 126012533  106 CLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLGKLKWDLA 153
Cdd:pfam00134  80 CLFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
CYCLIN_CCND_rpt2 cd20516
second cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 156-252 1.36e-39

second cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410220  Cd Length: 98  Bit Score: 133.89  E-value: 1.36e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533 156 IAHDFLALILHRLSLPSDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVLGLGACSM-SADELTELLAGITG 234
Cdd:cd20516    1 TPLDFLEHILHRLPLDSEDVDKVRKHAETFIALCATDYKFSSYPPSMIAAASILAALRGLLLHSGnSKEDLLEKLQQLTR 80

                         90
                 ....*....|....*...
gi 126012533 235 TEVDCLRACQEQIEAALR 252
Cdd:cd20516   81 IDEDLLRACQEQIEDLLE 98
CYCLIN_CCND1_rpt2 cd20576
second cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 158-260 5.24e-32

second cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410279  Cd Length: 110  Bit Score: 114.66  E-value: 5.24e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533 158 HDFLALILHRLSLPSDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVLGLGACS----MSADELTELLAGIT 233
Cdd:cd20576    3 HDFIEHFLSKMPLAEDTKQIIRKHAQTFVALCATDVKFISNPPSMIAAGSVAAAVQGLNLGNtnsfLSYQRLTRFLSQVI 82

                         90       100
                 ....*....|....*....|....*..
gi 126012533 234 GTEVDCLRACQEQIEAALRESLREAAQ 260
Cdd:cd20576   83 KCDPDCLRACQEQIESLLESSLRQAQQ 109
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 27-149 4.44e-27

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 102.33  E-value: 4.44e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533  27 VLQSLLRLEERYVPRASYFQcVQKEIKPHMRKMLAYWMLEVCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVC 106
Cdd:cd20504    6 IYEYLRESELKHRPKPDYMR-KQPDINPSMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLRSKLQLVGTAC 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 126012533 107 LLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLGKLK 149
Cdd:cd20504   85 MFIAAKYEEIYPPEVEEFVYITDDTYTKKQVLRMEHLVLKVLS 127
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 27-150 2.39e-24

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 95.07  E-value: 2.39e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533  27 VLQSLLRLEERYVPRASYFQcVQKEIKPHMRKMLAYWMLEVCEEQRCEEDVFPLAMNYLDRYLSCVP-TRKAQLQLLGTV 105
Cdd:cd20519    8 VWDLMLKKEELYKRDRDFLN-RHPSLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLSTQTnVPKTQLQLIGIT 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 126012533 106 CLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLGKLKW 150
Cdd:cd20519   87 CLFIAAKLEEIYPPKLSEFAYVTDGACTEDEILTMELIILKALNW 131
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 29-151 9.45e-23

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 91.32  E-value: 9.45e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533  29 QSLLRLEERYVPRASYFQCVQKEIKPHMRKMLAYWMLEVCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLL 108
Cdd:cd20562   14 LNLRVAELKRRPLPDYMEKIQRDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNYVNRQRLQLLGVSCML 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 126012533 109 LASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLGKLKWD 151
Cdd:cd20562   94 IASKYEEICAPQVEEFCYITDNTYTKQEVLEMEIDVLNALQFE 136
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 31-151 1.32e-20

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 85.49  E-value: 1.32e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533  31 LLRLEERYVPRASYFQcVQKEIKPHMRKMLAYWMLEVCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLA 110
Cdd:cd20561   12 LREMEVKCKPKVGYMK-KQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLA 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 126012533 111 SKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLGKLKWD 151
Cdd:cd20561   91 SKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFD 131
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 29-151 3.48e-20

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 85.28  E-value: 3.48e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533  29 QSLLRLEERYVPRASYFQcVQKEIKPHMRKMLAYWMLEVCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLL 108
Cdd:cd20560   42 QYLREAELKHRPKPGYMR-KQPDITTGMRTILVDWLVEVGEEYKLQTETLYLAVNYLDRFLSCMSVLRGKLQLVGTAAIL 120

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 126012533 109 LASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLGKLKWD 151
Cdd:cd20560  121 LASKYEEIYPPEVDEFVYITDDTYTKKQLLRMEHLLLKVLAFD 163
CYCLIN_vCyC_rpt1 cd20517
first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ...
 55-150 3.05e-19

first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410221  Cd Length: 99  Bit Score: 80.68  E-value: 3.05e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533  55 HMRKMLAYWMLEVCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAP 134
Cdd:cd20517    4 DNRKILLTWMFLVCESFELDKNVFPLAVSLLDRLLLKKQGTKETLQKTGAACLLIASKIRTVKPITVSKLTYLSCDCFTN 83

                         90
                 ....*....|....*.
gi 126012533 135 WQLREWEVLVLGKLKW 150
Cdd:cd20517   84 LELINQEKDILEALKW 99
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 29-149 6.19e-19

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 80.65  E-value: 6.19e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533  29 QSLLRLEERYVPRASYFQcVQKEIKPHMRKMLAYWMLEVceEQRCE---EDVFpLAMNYLDRYLSCVPTRKAQLQLLGTV 105
Cdd:cd20507   10 KYLRQLEKKYAIDPDYLS-GQPEITERMRAILVDWLVEV--HLKFKllpETLY-LTVNIIDRYLSKKQVPRKKLQLVGVT 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 126012533 106 CLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLGKLK 149
Cdd:cd20507   86 ALLIASKYEEIYPPEIKDFVYITDNAYTREEILQMERDILKTLD 129
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 27-150 5.82e-17

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 75.65  E-value: 5.82e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533  27 VLQSLLRLEERYVPRASYFQcVQKEIKPHMRKMLAYWMLEVCEEQRCEEDVFPLAMNYLDRY-LSCVPTRKAQLQLLGTV 105
Cdd:cd20580   14 VWLNMLKKESKYVHDKHFLQ-LHPALQPKMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKNINKSMLQLIGIT 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 126012533 106 CLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLGKLKW 150
Cdd:cd20580   93 SLFIASKLEEIYPPKLHEFAYVTDGACSEDDILDMELIILKALKW 137
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 57-152 6.62e-17

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 74.28  E-value: 6.62e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533  57 RKMLAYWMLEVCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQ 136
Cdd:cd20542    1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSLLQLLGITCLFIACKFEERFPPEVATLCYLTDDSYSKKQ 80

                         90
                 ....*....|....*.
gi 126012533 137 LREWEVLVLGKLKWDL 152
Cdd:cd20542   81 VLRMERRVLRRLRFDL 96
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 17-150 4.82e-16

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 73.37  E-value: 4.82e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533  17 PDPRLLGDQR--VLQSLLRLEERYVPRASYFQcVQKEIKPHMRKMLAYWMLEVCEEQRCEEDVFPLAMNYLDRYLSCVP- 93
Cdd:cd20579    2 PLPVLGWANRdeVWKNMLNKDKTYLRDKNFLQ-KHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQEn 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 126012533  94 TRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLGKLKW 150
Cdd:cd20579   81 VVKTRLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALKW 137
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 155-251 4.08e-15

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 69.96  E-value: 4.08e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533  155 VIAHDFLALILHRLSLPSDRQalVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVLGLGACsmsadELTELLAGITG 234
Cdd:pfam02984   1 PTPLSFLRRFSKAADYLHDLE--LRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLNSP-----EWTETLEHYTG 73

                          90
                  ....*....|....*..
gi 126012533  235 TEVDCLRACQEQIEAAL 251
Cdd:pfam02984  74 YSEEDLKPCVKLLLELL 90
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 31-150 8.70e-14

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 66.94  E-value: 8.70e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533  31 LLRLEERYVPRASYFQcVQKEIKPHMRKMLAYWMLEVCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLA 110
Cdd:cd20568   16 LRELELKTLPNPNYMD-DQKELRWKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLSKRVVSLNKLQLVGISALFIA 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 126012533 111 SKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLGKLKW 150
Cdd:cd20568   95 SKYEEVNSPSIKNFAYMTDGAYTVEDILRAERYMLNTLEF 134
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
31-207 1.39e-13

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 70.57  E-value: 1.39e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533  31 LLRLEERYVPRASYFQcVQKEIKPHMRKMLAYWMLEVCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLA 110
Cdd:COG5024  188 LLKLELIDLPNPNYLI-KQSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEKYQLVGISALFIA 266

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533 111 SKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLGKLKWDLAAVIAHDFlaliLHRLSLPSDRQALVKKHAQTFLALCA 190
Cdd:COG5024  267 SKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSF----LRRISKASDYDIFSRTPAKFSSEISP 342

                        170
                 ....*....|....*..
gi 126012533 191 TDYTFAMYPPSMIATGS 207
Cdd:COG5024  343 VDYKFIQISPSWCAAAA 359
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 63-145 2.13e-13

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 64.54  E-value: 2.13e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533    63 WMLEVCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVApwQLREWEV 142
Cdd:smart00385   2 FLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGYFTEE--EILRMER 79


                   ...
gi 126012533   143 LVL 145
Cdd:smart00385  80 LLL 82
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 44-150 7.75e-13

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 64.67  E-value: 7.75e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533  44 YFQCVQKEIKPHMRKMLAYWMLEVCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEK 123
Cdd:cd20567   41 YYMSQQPDINEKMRAILIDWLIEVHLKFELMPETLYLTVNLIDRFLSVKQVPRKELQLVGVTAMLIASKYEEIWAPEVND 120

                         90       100
                 ....*....|....*....|....*..
gi 126012533 124 LCIYTDQAVAPWQLREWEVLVLGKLKW 150
Cdd:cd20567  121 FVYISDNAYTRKQILVMEKTMLNTLEF 147
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 18-150 2.30e-12

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 62.96  E-value: 2.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533  18 DPRLLGD--QRVLQSLLRLEERYVPRASYFQcvQKEIKPHMRKMLAYWMLEVCEEQRCEEDVFPLAMNYLDRYLSCVPTR 95
Cdd:cd20566    1 NPQLCSDyvKDIYQYLRQLEVQQSIRPHYLD--GKEINERMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQPVS 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 126012533  96 KAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLGKLKW 150
Cdd:cd20566   79 RKKLQLVGVTALLLASKYEEMYSPEIGDFVYITDNAYTKAQIREMEMLILKELNF 133
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 31-150 6.44e-12

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 61.82  E-value: 6.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533  31 LLRLEERYVPRASYFQcvQKEIKPHMRKMLAYWMLEVCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLA 110
Cdd:cd20565   12 LRQLEEEQAVRPKYLE--GQEVTGNMRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQNNPVPKKMLQLVGVTAMFIA 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 126012533 111 SKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLGKLKW 150
Cdd:cd20565   90 SKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALDF 129
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 35-151 7.53e-12

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 61.89  E-value: 7.53e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533  35 EERYVPRaSYFQcVQKEIKPHMRKMLAYWMLEVCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLR 114
Cdd:cd20508   28 EEKFVVP-DYLE-KQTELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDLYLSKKVVKKEKLQLLGATAILIASKFD 105

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 126012533 115 ETTPLTIEKLCIYTDQAVAPWQLREWEVLVLGKLKWD 151
Cdd:cd20508  106 ERCPPCVDDFLYICDDAYTREELLKMEREILKTLDFD 142
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 56-148 4.80e-11

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 58.11  E-value: 4.80e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533  56 MRKMLAYWMLEVCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPW 135
Cdd:cd20536    1 MRAKLISWLIPVHRHFNLSQETLFLAVNILDRFLATTPVARDCFQLLGVTSLLIACKQEEIYPPEVKDLLALCCGAYTRE 80

                         90
                 ....*....|...
gi 126012533 136 QLREWEVLVLGKL 148
Cdd:cd20536   81 QICNLECIILTKL 93
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 63-150 1.47e-10

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 56.94  E-value: 1.47e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533  63 WMLEVCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQ---LQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAV-APWQLR 138
Cdd:cd20543    8 WILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPKDKpwmLQLLAVACLSLAAKMEETDVPLLVDLQVEEPKYVfEAKTIQ 87

                         90
                 ....*....|..
gi 126012533 139 EWEVLVLGKLKW 150
Cdd:cd20543   88 RMELLVLSTLEW 99
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 63-141 7.39e-10

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 54.72  E-value: 7.39e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 126012533  63 WMLEVCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLREtTPLTIEKLCIYTDqaVAPWQLREWE 141
Cdd:cd00043    5 FIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEE-LPRTLKEIAKVSG--VSEKELRKAE 80
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 54-129 2.64e-09

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 53.47  E-value: 2.64e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 126012533  54 PHMRKMLAYWMLEVCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTD 129
Cdd:cd20521    1 DTMRYILVDWLVEVATMKDFSSLTLHVAVSCVDRYLMVRKVPRSKLQLLGIACMVIATRFLGKDILTIREAAWLTD 76
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 55-150 1.12e-08

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 51.84  E-value: 1.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533  55 HMRKMLAYWMLEVCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLT--IEKLCIYTDQAV 132
Cdd:cd20528    5 HLRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQLHLVALTCLLLAAKFEELDDNIpkISDLNRYLCNSV 84

                         90
                 ....*....|....*....
gi 126012533 133 APWQ-LREWEVLVLGKLKW 150
Cdd:cd20528   85 YSKQeYLQMELLILEFFQW 103
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 76-151 2.61e-07

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 47.76  E-value: 2.61e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 126012533  76 DVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTP--LTIEKLCIYTDQAVAPWQLREWEVLVLGKLKWD 151
Cdd:cd20559   18 QTFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASKFWESKArvPLLSELSKMCCNSYGEELFIQMEMHILNTLNWD 95
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 63-152 4.95e-07

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 47.31  E-value: 4.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533  63 WMLEVCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTP--LTIEKLCIYTDQAVAPWQLREW 140
Cdd:cd20526    8 WLAELNSQFKFYPETFALAVSILDRFLASVKARPKYLRCIAISCLFLAAKTNEEDEviPSTKDLVRVSKCGCSVAEVLRM 87

                         90
                 ....*....|..
gi 126012533 141 EVLVLGKLKWDL 152
Cdd:cd20526   88 ERIILDKLHWDL 99
CYCLIN_AtCycD-like_rpt2 cd20544
second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant ...
 155-247 3.29e-04

second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410247  Cd Length: 90  Bit Score: 38.83  E-value: 3.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533 155 VIAHDFLALILHRLSLPSDRQALVKKHAQTFLALCAtDYTFAMYPPSMIATGSIGAAVLGLGACSMSADELTELLAGItg 234
Cdd:cd20544    1 VTPFSFLDYFISKIGLSDSREELLSRATELLLSTTK-DIRFLEYRPSVIAAAAILCALDELPPDDADDASSRLSLLLS-- 77

                         90
                 ....*....|...
gi 126012533 235 TEVDCLRACQEQI 247
Cdd:cd20544   78 PNKEKVKKCYELM 90
CYCLIN_vCyC_rpt2 cd20518
second cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ...
 156-253 1.34e-03

second cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410222  Cd Length: 100  Bit Score: 37.53  E-value: 1.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533 156 IAHDFLALILHRLSLPSDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVLGLGACSMSADELTELLAGITGT 235
Cdd:cd20518    1 LATDVTSPLLLKLKGGSDQLDALHHAVNTLITKALVDPNTGSLPPSLISAAGCLLLVPANVTPQTHSGGVLPRLASILGC 80

                         90
                 ....*....|....*...
gi 126012533 236 EVDCLRACQEQIEAALRE 253
Cdd:cd20518   81 SVSTLQAAVEQVLTSLSD 98
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 80-208 1.77e-03

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 39.33  E-value: 1.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533  80 LAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTP-LTIEKLCIYTDQAVAPWQLR----EWEVLVLGKLKWDLAA 154
Cdd:COG5333   68 TAILFFSRFYLKNSVEEISLYSVVTTCVYLACKVEDTPRdISIESFEARDLWSEEPKSSRerilEYEFELLEALDFDLHV 147

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 126012533 155 VIAHDFLALILH--RLSLPSDRQALVKKHAQTFLALcatdYTFAMYPPSMIATGSI 208
Cdd:COG5333  148 HHPYKYLEGFLKdlQEKDKYKLLQIAWKIINDALRT----DLCLLYPPHIIALAAL 199
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 157-247 2.87e-03

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 36.13  E-value: 2.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126012533 157 AHDFLALILHRLSLPSDRQALvkkhAQTFLALCATDYTFAMYPPSMIATGSIgaaVLGLGACSMSADElTELLAGITGTE 236
Cdd:cd20537    3 PLSFLRRYLSLLGLDEKVRHL----ARYLLELSLLDYEFLKYRPSLIAAAAL---YLARKILGEPPPS-PQLLQLVTGYS 74

                         90
                 ....*....|.
gi 126012533 237 VDCLRACQEQI 247
Cdd:cd20537   75 ENDLQECAKEL 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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