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Conserved domains on  [gi|197209974|ref|NP_001073991|]
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coiled-coil and C2 domain-containing protein 2A isoform a [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF5523 pfam17661
Family of unknown function (DUF5523); This is a family of unknown function found in Eukaryotes. ...
 131-383 3.12e-127

Family of unknown function (DUF5523); This is a family of unknown function found in Eukaryotes. Family members such as the human CC1D2A protein carry the domain architecture where pfam15625 and pfam00168 are found at the C-terminal region of this family. However, other family members such as Swiss:D6R9V3, do not carry either of the above mentioned Pfam families.


:

Pssm-ID: 465443  Cd Length: 255  Bit Score: 397.03  E-value: 3.12e-127
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197209974   131 LRSPSKKELETEFGTEPGKEVERTQQEVD-SQSYSRVKFHDSARKIKPKPQVPPGFPSAEEAYNFFTFNFDPEPEGSEEK 209
Cdd:pfam17661    1 LRSLRERETETRFDRESKEENRRIIEEDEgSSLSSRVKFRDSVKKVKSKSQVPPGLPSAEEAYNFFTFNFDPEPEEPFEK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197209974   210 PKARHRAGTNQEEEEGEEEEPPAQGGG---KEMDEEELLNGDDAEDFLLglDHVADDFVAVRPADYESIHDRLQMEREML 286
Cdd:pfam17661   81 SKEKERAESNQEEEEGEEEEAEEGEEEqeaEKMDEEELLVGDDEEDFLI--DQTADDFLEVRPAEYESYHERLKKEKEIL 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197209974   287 FIPSRQTVPTYKKLPENVQPRFLEDEGLYTGVRPEVARTNQNIMENRLLMQDPERRWFGDDGRILALPNPIKPFPSRPPV 366
Cdd:pfam17661  159 FVPSSLTVPTSKKLPENVQPRYLEDEGLYVGERPEVSKTNQNIMENRLLKQEEGKKWFGDDGRILALPNPIKQSPTRPPI 238

                          250
                   ....*....|....*..
gi 197209974   367 LTQEQSIKAELETLYKK 383
Cdd:pfam17661  239 FSLEESLKPELETLYKK 255
CC2D2AN-C2 pfam15625
CC2D2A N-terminal C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated ...
 645-819 1.53e-77

CC2D2A N-terminal C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated for ciliophathies. A recent study has shown that many of them contain various new versions of C2 domains which are predicted to mediate membrane localizations for Y-shaped linkers of transition zone of cilia. This is the first C2 domain of ciliary CC2D2A proteins which also have another C2 domain (CC2D2AC-C2) and a new inactive transglutaminase-like peptidase domain (CC2D2A-TGL).


:

Pssm-ID: 464780  Cd Length: 174  Bit Score: 253.86  E-value: 1.53e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197209974   645 PWEPTLVPELSLAGSVTPNDQCPRAEVSRREDVKKRSVYLKVLFNNKEVSRTVSRPLGADFRVHFGQIFNLQIVNWPESL 724
Cdd:pfam15625    1 PGEPILIPELTATGEITPLSICPRAEQQRRQDVQKTSYFVKILINGKEVSRTRSVPLSSDFRVHFNEIFSIRITNWPESI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197209974   725 TLQVYETVGHSSPTLLAEVFLPIPETTVVTGRAP-TEEVEFSSNQHVTLDHEGVGSGVPfsFEADGSNQLTLMTSGKVSH 803
Cdd:pfam15625   81 KLEIYETSGKLSKTLLAEVFIPVPGSTVLTGSAPqLEEYEFSSDPRVSFDHEGVGSGVP--LEADGSNSLGLLTSGTVSY 158

                          170
                   ....*....|....*.
gi 197209974   804 SVAWAIGENGIPLIPP 819
Cdd:pfam15625  159 SVSWAVDENGVPLAPP 174
C2 super family cl14603
C2 domain; The C2 domain was first identified in PKC. C2 domains fold into an 8-standed ...
 1097-1135 1.76e-03

C2 domain; The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.


The actual alignment was detected with superfamily member cd04018:

Pssm-ID: 472691 [Multi-domain]  Cd Length: 151  Bit Score: 40.69  E-value: 1.76e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 197209974 1097 VLVRPFVEVSFQ-RTVCHTTTAEGPNPSWNEELELPFRAP 1135
Cdd:cd04018    33 ELVDPYVEVSFAgQKVKTSVKKNSYNPEWNEQIVFPEMFP 72
DDA1 super family cl10867
Det1 complexing ubiquitin ligase; DDA1 (De-etiolated 1, Damaged DNA binding protein 1 ...
 1066-1099 3.61e-03

Det1 complexing ubiquitin ligase; DDA1 (De-etiolated 1, Damaged DNA binding protein 1 associated 1) protein binds strongly with DDB1 and Det1 forming a DDD complex which is part of the ubiquitin conjugation system.


The actual alignment was detected with superfamily member pfam10172:

Pssm-ID: 401980  Cd Length: 66  Bit Score: 37.34  E-value: 3.61e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 197209974  1066 PSRSSRMFSEKHAAS---------PSTYSPTHNADYPLGQVLV 1099
Cdd:pfam10172    7 PSYDPSNFSRFRPSDssikpsgkrPSVYLPTHDTDPPPEQVIV 49
 
Name Accession Description Interval E-value
DUF5523 pfam17661
Family of unknown function (DUF5523); This is a family of unknown function found in Eukaryotes. ...
 131-383 3.12e-127

Family of unknown function (DUF5523); This is a family of unknown function found in Eukaryotes. Family members such as the human CC1D2A protein carry the domain architecture where pfam15625 and pfam00168 are found at the C-terminal region of this family. However, other family members such as Swiss:D6R9V3, do not carry either of the above mentioned Pfam families.


Pssm-ID: 465443  Cd Length: 255  Bit Score: 397.03  E-value: 3.12e-127
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197209974   131 LRSPSKKELETEFGTEPGKEVERTQQEVD-SQSYSRVKFHDSARKIKPKPQVPPGFPSAEEAYNFFTFNFDPEPEGSEEK 209
Cdd:pfam17661    1 LRSLRERETETRFDRESKEENRRIIEEDEgSSLSSRVKFRDSVKKVKSKSQVPPGLPSAEEAYNFFTFNFDPEPEEPFEK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197209974   210 PKARHRAGTNQEEEEGEEEEPPAQGGG---KEMDEEELLNGDDAEDFLLglDHVADDFVAVRPADYESIHDRLQMEREML 286
Cdd:pfam17661   81 SKEKERAESNQEEEEGEEEEAEEGEEEqeaEKMDEEELLVGDDEEDFLI--DQTADDFLEVRPAEYESYHERLKKEKEIL 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197209974   287 FIPSRQTVPTYKKLPENVQPRFLEDEGLYTGVRPEVARTNQNIMENRLLMQDPERRWFGDDGRILALPNPIKPFPSRPPV 366
Cdd:pfam17661  159 FVPSSLTVPTSKKLPENVQPRYLEDEGLYVGERPEVSKTNQNIMENRLLKQEEGKKWFGDDGRILALPNPIKQSPTRPPI 238

                          250
                   ....*....|....*..
gi 197209974   367 LTQEQSIKAELETLYKK 383
Cdd:pfam17661  239 FSLEESLKPELETLYKK 255
CC2D2AN-C2 pfam15625
CC2D2A N-terminal C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated ...
 645-819 1.53e-77

CC2D2A N-terminal C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated for ciliophathies. A recent study has shown that many of them contain various new versions of C2 domains which are predicted to mediate membrane localizations for Y-shaped linkers of transition zone of cilia. This is the first C2 domain of ciliary CC2D2A proteins which also have another C2 domain (CC2D2AC-C2) and a new inactive transglutaminase-like peptidase domain (CC2D2A-TGL).


Pssm-ID: 464780  Cd Length: 174  Bit Score: 253.86  E-value: 1.53e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197209974   645 PWEPTLVPELSLAGSVTPNDQCPRAEVSRREDVKKRSVYLKVLFNNKEVSRTVSRPLGADFRVHFGQIFNLQIVNWPESL 724
Cdd:pfam15625    1 PGEPILIPELTATGEITPLSICPRAEQQRRQDVQKTSYFVKILINGKEVSRTRSVPLSSDFRVHFNEIFSIRITNWPESI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197209974   725 TLQVYETVGHSSPTLLAEVFLPIPETTVVTGRAP-TEEVEFSSNQHVTLDHEGVGSGVPfsFEADGSNQLTLMTSGKVSH 803
Cdd:pfam15625   81 KLEIYETSGKLSKTLLAEVFIPVPGSTVLTGSAPqLEEYEFSSDPRVSFDHEGVGSGVP--LEADGSNSLGLLTSGTVSY 158

                          170
                   ....*....|....*.
gi 197209974   804 SVAWAIGENGIPLIPP 819
Cdd:pfam15625  159 SVSWAVDENGVPLAPP 174
C2C_Ferlin cd04018
C2 domain third repeat in Ferlin; Ferlins are involved in vesicle fusion events. Ferlins and ...
 1097-1135 1.76e-03

C2 domain third repeat in Ferlin; Ferlins are involved in vesicle fusion events. Ferlins and other proteins, such as Synaptotagmins, are implicated in facilitating the fusion process when cell membranes fuse together. There are six known human Ferlins: Dysferlin (Fer1L1), Otoferlin (Fer1L2), Myoferlin (Fer1L3), Fer1L4, Fer1L5, and Fer1L6. Defects in these genes can lead to a wide range of diseases including muscular dystrophy (dysferlin), deafness (otoferlin), and infertility (fer-1, fertilization factor-1). Structurally they have 6 tandem C2 domains, designated as (C2A-C2F) and a single C-terminal transmembrane domain, though there is a new study that disputes this and claims that there are actually 7 tandem C2 domains with another C2 domain inserted between C2D and C2E. In a subset of them (Dysferlin, Myoferlin, and Fer1) there is an additional conserved domain called DysF. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the third C2 repeat, C2C, and has a type-II topology.


Pssm-ID: 175985 [Multi-domain]  Cd Length: 151  Bit Score: 40.69  E-value: 1.76e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 197209974 1097 VLVRPFVEVSFQ-RTVCHTTTAEGPNPSWNEELELPFRAP 1135
Cdd:cd04018    33 ELVDPYVEVSFAgQKVKTSVKKNSYNPEWNEQIVFPEMFP 72
DDA1 pfam10172
Det1 complexing ubiquitin ligase; DDA1 (De-etiolated 1, Damaged DNA binding protein 1 ...
 1066-1099 3.61e-03

Det1 complexing ubiquitin ligase; DDA1 (De-etiolated 1, Damaged DNA binding protein 1 associated 1) protein binds strongly with DDB1 and Det1 forming a DDD complex which is part of the ubiquitin conjugation system.


Pssm-ID: 401980  Cd Length: 66  Bit Score: 37.34  E-value: 3.61e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 197209974  1066 PSRSSRMFSEKHAAS---------PSTYSPTHNADYPLGQVLV 1099
Cdd:pfam10172    7 PSYDPSNFSRFRPSDssikpsgkrPSVYLPTHDTDPPPEQVIV 49
 
Name Accession Description Interval E-value
DUF5523 pfam17661
Family of unknown function (DUF5523); This is a family of unknown function found in Eukaryotes. ...
 131-383 3.12e-127

Family of unknown function (DUF5523); This is a family of unknown function found in Eukaryotes. Family members such as the human CC1D2A protein carry the domain architecture where pfam15625 and pfam00168 are found at the C-terminal region of this family. However, other family members such as Swiss:D6R9V3, do not carry either of the above mentioned Pfam families.


Pssm-ID: 465443  Cd Length: 255  Bit Score: 397.03  E-value: 3.12e-127
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197209974   131 LRSPSKKELETEFGTEPGKEVERTQQEVD-SQSYSRVKFHDSARKIKPKPQVPPGFPSAEEAYNFFTFNFDPEPEGSEEK 209
Cdd:pfam17661    1 LRSLRERETETRFDRESKEENRRIIEEDEgSSLSSRVKFRDSVKKVKSKSQVPPGLPSAEEAYNFFTFNFDPEPEEPFEK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197209974   210 PKARHRAGTNQEEEEGEEEEPPAQGGG---KEMDEEELLNGDDAEDFLLglDHVADDFVAVRPADYESIHDRLQMEREML 286
Cdd:pfam17661   81 SKEKERAESNQEEEEGEEEEAEEGEEEqeaEKMDEEELLVGDDEEDFLI--DQTADDFLEVRPAEYESYHERLKKEKEIL 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197209974   287 FIPSRQTVPTYKKLPENVQPRFLEDEGLYTGVRPEVARTNQNIMENRLLMQDPERRWFGDDGRILALPNPIKPFPSRPPV 366
Cdd:pfam17661  159 FVPSSLTVPTSKKLPENVQPRYLEDEGLYVGERPEVSKTNQNIMENRLLKQEEGKKWFGDDGRILALPNPIKQSPTRPPI 238

                          250
                   ....*....|....*..
gi 197209974   367 LTQEQSIKAELETLYKK 383
Cdd:pfam17661  239 FSLEESLKPELETLYKK 255
CC2D2AN-C2 pfam15625
CC2D2A N-terminal C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated ...
 645-819 1.53e-77

CC2D2A N-terminal C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated for ciliophathies. A recent study has shown that many of them contain various new versions of C2 domains which are predicted to mediate membrane localizations for Y-shaped linkers of transition zone of cilia. This is the first C2 domain of ciliary CC2D2A proteins which also have another C2 domain (CC2D2AC-C2) and a new inactive transglutaminase-like peptidase domain (CC2D2A-TGL).


Pssm-ID: 464780  Cd Length: 174  Bit Score: 253.86  E-value: 1.53e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197209974   645 PWEPTLVPELSLAGSVTPNDQCPRAEVSRREDVKKRSVYLKVLFNNKEVSRTVSRPLGADFRVHFGQIFNLQIVNWPESL 724
Cdd:pfam15625    1 PGEPILIPELTATGEITPLSICPRAEQQRRQDVQKTSYFVKILINGKEVSRTRSVPLSSDFRVHFNEIFSIRITNWPESI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197209974   725 TLQVYETVGHSSPTLLAEVFLPIPETTVVTGRAP-TEEVEFSSNQHVTLDHEGVGSGVPfsFEADGSNQLTLMTSGKVSH 803
Cdd:pfam15625   81 KLEIYETSGKLSKTLLAEVFIPVPGSTVLTGSAPqLEEYEFSSDPRVSFDHEGVGSGVP--LEADGSNSLGLLTSGTVSY 158

                          170
                   ....*....|....*.
gi 197209974   804 SVAWAIGENGIPLIPP 819
Cdd:pfam15625  159 SVSWAVDENGVPLAPP 174
C2C_Ferlin cd04018
C2 domain third repeat in Ferlin; Ferlins are involved in vesicle fusion events. Ferlins and ...
 1097-1135 1.76e-03

C2 domain third repeat in Ferlin; Ferlins are involved in vesicle fusion events. Ferlins and other proteins, such as Synaptotagmins, are implicated in facilitating the fusion process when cell membranes fuse together. There are six known human Ferlins: Dysferlin (Fer1L1), Otoferlin (Fer1L2), Myoferlin (Fer1L3), Fer1L4, Fer1L5, and Fer1L6. Defects in these genes can lead to a wide range of diseases including muscular dystrophy (dysferlin), deafness (otoferlin), and infertility (fer-1, fertilization factor-1). Structurally they have 6 tandem C2 domains, designated as (C2A-C2F) and a single C-terminal transmembrane domain, though there is a new study that disputes this and claims that there are actually 7 tandem C2 domains with another C2 domain inserted between C2D and C2E. In a subset of them (Dysferlin, Myoferlin, and Fer1) there is an additional conserved domain called DysF. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the third C2 repeat, C2C, and has a type-II topology.


Pssm-ID: 175985 [Multi-domain]  Cd Length: 151  Bit Score: 40.69  E-value: 1.76e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 197209974 1097 VLVRPFVEVSFQ-RTVCHTTTAEGPNPSWNEELELPFRAP 1135
Cdd:cd04018    33 ELVDPYVEVSFAgQKVKTSVKKNSYNPEWNEQIVFPEMFP 72
DDA1 pfam10172
Det1 complexing ubiquitin ligase; DDA1 (De-etiolated 1, Damaged DNA binding protein 1 ...
 1066-1099 3.61e-03

Det1 complexing ubiquitin ligase; DDA1 (De-etiolated 1, Damaged DNA binding protein 1 associated 1) protein binds strongly with DDB1 and Det1 forming a DDD complex which is part of the ubiquitin conjugation system.


Pssm-ID: 401980  Cd Length: 66  Bit Score: 37.34  E-value: 3.61e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 197209974  1066 PSRSSRMFSEKHAAS---------PSTYSPTHNADYPLGQVLV 1099
Cdd:pfam10172    7 PSYDPSNFSRFRPSDssikpsgkrPSVYLPTHDTDPPPEQVIV 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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