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Conserved domains on  [gi|122937422|ref|NP_001073962|]
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zinc finger protein 823 isoform 1 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016931)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-40 1.89e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.75  E-value: 1.89e-19
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 122937422    3 SVAFEDVAVNFTQEEWALLGPSQKSLYRNVMQETIRNL 40
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNL 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
109-546 3.94e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.04  E-value: 3.94e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937422 109 GHSSLNCNIRVDTGHKSCEHQEYGEKPYTHKQRGKAISHQHSFQT-HERPPTGKKPFDC--KECAKTFSSLGNLRRHMAA 185
Cdd:COG5048    6 SQSSSSNNSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTrHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937422 186 HHGDGPYKC-KLCGKAFVWPSLFHLHERTHTGEKPYECKQCSKAFPFYSSYLRHERIHTGEKAYECKQCSKAFPDYSTY- 263
Cdd:COG5048   86 HHNNPSDLNsKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSn 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937422 264 ---LRHERTHTGEKPYKCTQcgkafscyyyTRLHERTHTGEQPYACKQCGKTFYHHTSFRRHMIRHTGDGPHKCKICGKG 340
Cdd:COG5048  166 slhPPLPANSLSKDPSSNLS----------LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937422 341 FDC------PSSVRNHETTHTGEKPYECKQCGKVLSHSSSFRSHMITHTGDG-PQKCKICGKAFGCPSLFQRHERT--HT 411
Cdd:COG5048  236 SPKsllsqsPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHS 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937422 412 GE--KPYQC--KQCGKAFSLAGSLRRHEATHTGVKPYKC---QCGKAFSDLS------SFQNHETTHTgEKPYEC--KEC 476
Cdd:COG5048  316 GEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEkllNSSSKFSPLLnneppqSLQQYKDLKN-DKKSETlsNSC 394

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 122937422 477 GKAFSCFKYLSQHKRTHTVEKPYECK--TCRKAFSHFSNLKVHERIHSGEKPYECKECGKAFSWLTCLLRHE 546
Cdd:COG5048  395 IRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
542-566 1.10e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.10e-03
                          10        20
                  ....*....|....*....|....*
gi 122937422  542 LLRHERIHTGEKPYECLQCGKAFTR 566
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-40 1.89e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.75  E-value: 1.89e-19
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 122937422    3 SVAFEDVAVNFTQEEWALLGPSQKSLYRNVMQETIRNL 40
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNL 38
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-40 9.15e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.12  E-value: 9.15e-17
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 122937422   4 VAFEDVAVNFTQEEWALLGPSQKSLYRNVMQETIRNL 40
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
KRAB smart00349
krueppel associated box;
4-40 1.35e-16

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 74.17  E-value: 1.35e-16
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 122937422     4 VAFEDVAVNFTQEEWALLGPSQKSLYRNVMQETIRNL 40
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
109-546 3.94e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.04  E-value: 3.94e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937422 109 GHSSLNCNIRVDTGHKSCEHQEYGEKPYTHKQRGKAISHQHSFQT-HERPPTGKKPFDC--KECAKTFSSLGNLRRHMAA 185
Cdd:COG5048    6 SQSSSSNNSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTrHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937422 186 HHGDGPYKC-KLCGKAFVWPSLFHLHERTHTGEKPYECKQCSKAFPFYSSYLRHERIHTGEKAYECKQCSKAFPDYSTY- 263
Cdd:COG5048   86 HHNNPSDLNsKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSn 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937422 264 ---LRHERTHTGEKPYKCTQcgkafscyyyTRLHERTHTGEQPYACKQCGKTFYHHTSFRRHMIRHTGDGPHKCKICGKG 340
Cdd:COG5048  166 slhPPLPANSLSKDPSSNLS----------LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937422 341 FDC------PSSVRNHETTHTGEKPYECKQCGKVLSHSSSFRSHMITHTGDG-PQKCKICGKAFGCPSLFQRHERT--HT 411
Cdd:COG5048  236 SPKsllsqsPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHS 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937422 412 GE--KPYQC--KQCGKAFSLAGSLRRHEATHTGVKPYKC---QCGKAFSDLS------SFQNHETTHTgEKPYEC--KEC 476
Cdd:COG5048  316 GEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEkllNSSSKFSPLLnneppqSLQQYKDLKN-DKKSETlsNSC 394

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 122937422 477 GKAFSCFKYLSQHKRTHTVEKPYECK--TCRKAFSHFSNLKVHERIHSGEKPYECKECGKAFSWLTCLLRHE 546
Cdd:COG5048  395 IRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
403-426 6.52e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.52e-04
                          10        20
                  ....*....|....*....|....
gi 122937422  403 FQRHERTHTGEKPYQCKQCGKAFS 426
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
542-566 1.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.10e-03
                          10        20
                  ....*....|....*....|....*
gi 122937422  542 LLRHERIHTGEKPYECLQCGKAFTR 566
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-40 1.89e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.75  E-value: 1.89e-19
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 122937422    3 SVAFEDVAVNFTQEEWALLGPSQKSLYRNVMQETIRNL 40
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNL 38
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-40 9.15e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.12  E-value: 9.15e-17
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 122937422   4 VAFEDVAVNFTQEEWALLGPSQKSLYRNVMQETIRNL 40
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
KRAB smart00349
krueppel associated box;
4-40 1.35e-16

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 74.17  E-value: 1.35e-16
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 122937422     4 VAFEDVAVNFTQEEWALLGPSQKSLYRNVMQETIRNL 40
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
109-546 3.94e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.04  E-value: 3.94e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937422 109 GHSSLNCNIRVDTGHKSCEHQEYGEKPYTHKQRGKAISHQHSFQT-HERPPTGKKPFDC--KECAKTFSSLGNLRRHMAA 185
Cdd:COG5048    6 SQSSSSNNSVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTrHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937422 186 HHGDGPYKC-KLCGKAFVWPSLFHLHERTHTGEKPYECKQCSKAFPFYSSYLRHERIHTGEKAYECKQCSKAFPDYSTY- 263
Cdd:COG5048   86 HHNNPSDLNsKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSn 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937422 264 ---LRHERTHTGEKPYKCTQcgkafscyyyTRLHERTHTGEQPYACKQCGKTFYHHTSFRRHMIRHTGDGPHKCKICGKG 340
Cdd:COG5048  166 slhPPLPANSLSKDPSSNLS----------LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937422 341 FDC------PSSVRNHETTHTGEKPYECKQCGKVLSHSSSFRSHMITHTGDG-PQKCKICGKAFGCPSLFQRHERT--HT 411
Cdd:COG5048  236 SPKsllsqsPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHS 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937422 412 GE--KPYQC--KQCGKAFSLAGSLRRHEATHTGVKPYKC---QCGKAFSDLS------SFQNHETTHTgEKPYEC--KEC 476
Cdd:COG5048  316 GEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEkllNSSSKFSPLLnneppqSLQQYKDLKN-DKKSETlsNSC 394

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 122937422 477 GKAFSCFKYLSQHKRTHTVEKPYECK--TCRKAFSHFSNLKVHERIHSGEKPYECKECGKAFSWLTCLLRHE 546
Cdd:COG5048  395 IRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
191-605 2.55e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.79  E-value: 2.55e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937422 191 PYKCKLCGKAFVWPSLFHLHERTHTGEKPYEC--KQCSKAFPFYSSYLRHERIHTGEKAYEC-KQCSKAFPDYSTYLRHE 267
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937422 268 RTHTGEKPYKCTQCGKAFSCYYYTRLHERTHTGEQPYACKQCgkTFYHHTSFRRHMIRHTGDGPHKCKICGKgfdcPSSV 347
Cdd:COG5048  113 SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGN--NSSSVNTPQSNSLHPPLPANSLSKDPSS----NLSL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937422 348 RNHETTHTGEKPYECKQCGKVLSHSSSFRSHMITHTGDGPQKCKICGkaFGCPSLFQRHERTHTGEKpyqckqcgkafsl 427
Cdd:COG5048  187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS--QLSPKSLLSQSPSSLSSS------------- 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937422 428 agslrrHEATHTGVKPYKCQCGKAFSDLSSFQNHETTHTG-EKPYECKECGKAFSCFKYLSQHKRT--HTVE--KPYEC- 501
Cdd:COG5048  252 ------DSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCp 325

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937422 502 -KTCRKAFSHFSNLKVHERIHSGEKPYECKEC-------GKAFSWLTCLLRHERIHTGEKPYECL--QCGKAFTRSRFLR 571
Cdd:COG5048  326 ySLCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLS 405

                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 122937422 572 GHEKTHTGEKLYECK--ECGKALSSLRSLHRHKRTH 605
Cdd:COG5048  406 LHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
274-557 7.47e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 7.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937422 274 KPYKCTQCGKAFSCYYYTRLHERTHTGEQPYAC--KQCGKTFYHHTSFRRHMIRHTGDGPHKCKICGKG--FDCPSSVRN 349
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937422 350 HETTHTgEKPYECKQCGKVLSHSSSFRSHMITHTGDGPQKCKICGKAFG----------------------CPSLFQRHE 407
Cdd:COG5048  112 SSSSNS-NDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVntpqsnslhpplpanslskdpsSNLSLLISS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937422 408 RTHTGEKPYQCKQCG----KAFSLAGSLRRHEAThTGVKPYKCQCGKAFSDLSSFQNHETthtgeKPYECKECGKAFSCF 483
Cdd:COG5048  191 NVSTSIPSSSENSPLsssySIPSSSSDQNLENSS-SSLPLTTNSQLSPKSLLSQSPSSLS-----SSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937422 484 KYLSQHKRTHTVE----------KPYECKTCRKAFSHFSNLKVHER--IHSGE--KPYECKE--CGKAFSWLTCLLRHER 547
Cdd:COG5048  265 LPTASSQSSSPNEsdsssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                        330
                 ....*....|
gi 122937422 548 IHTGEKPYEC 557
Cdd:COG5048  345 LHTSISPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
252-436 1.37e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937422 252 QCSKAFPDYSTYLRHERTHTG-EKPYKCTQCGKAFSCYYYTRLHERT--HTGE--QPYAC--KQCGKTFYHHTSFRRHMI 324
Cdd:COG5048  265 LPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHIL 344

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122937422 325 RHTGDGPHKCKICGKGFD-------CPSSVRNHETTHTGEKPYEC--KQCGKVLSHSSSFRSHMITHTGDGP--QKCKIC 393
Cdd:COG5048  345 LHTSISPAKEKLLNSSSKfspllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 122937422 394 GKAFGCPSLFQRHERTHTGEKPYQCKQCGKAFSLAGSLRRHEA 436
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
403-426 6.52e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.52e-04
                          10        20
                  ....*....|....*....|....
gi 122937422  403 FQRHERTHTGEKPYQCKQCGKAFS 426
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
513-537 6.92e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.92e-04
                          10        20
                  ....*....|....*....|....*
gi 122937422  513 NLKVHERIHSGEKPYECKECGKAFS 537
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
265-287 7.06e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.06e-04
                          10        20
                  ....*....|....*....|...
gi 122937422  265 RHERTHTGEKPYKCTQCGKAFSC 287
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
542-566 1.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.10e-03
                          10        20
                  ....*....|....*....|....*
gi 122937422  542 LLRHERIHTGEKPYECLQCGKAFTR 566
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
485-510 2.04e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.04e-03
                          10        20
                  ....*....|....*....|....*.
gi 122937422  485 YLSQHKRTHTVEKPYECKTCRKAFSH 510
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
178-202 3.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.53e-03
                          10        20
                  ....*....|....*....|....*
gi 122937422  178 NLRRHMAAHHGDGPYKCKLCGKAFV 202
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
457-482 4.93e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.93e-03
                          10        20
                  ....*....|....*....|....*.
gi 122937422  457 SFQNHETTHTGEKPYECKECGKAFSC 482
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
318-343 7.68e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.68e-03
                          10        20
                  ....*....|....*....|....*.
gi 122937422  318 SFRRHMIRHTGDGPHKCKICGKGFDC 343
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
210-229 9.63e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.63e-03
                          10        20
                  ....*....|....*....|
gi 122937422  210 HERTHTGEKPYECKQCSKAF 229
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
497-562 9.94e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 9.94e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 122937422 497 KPYECKTCRKAFSHFSNLKVHERIHSGEKPYEC--KECGKAFSWLTCLLRHERIHTGEKPYECLQCGK 562
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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