nucleotide-sugar transporter family protein may be involved in the transport of nucleotide sugars, similar to human UDP-galactose translocator and CMP-sialic acid transporter
Nucleotide-sugar transporter; This family of membrane proteins transport nucleotide sugars ...
23-374
2.59e-32
Nucleotide-sugar transporter; This family of membrane proteins transport nucleotide sugars from the cytoplasm into Golgi vesicles. Swiss:P78382 transports CMP-sialic acid, Swiss:P78381 transports UDP-galactose and Swiss:Q9Y2D2 transports UDP-GlcNAc.
The actual alignment was detected with superfamily member pfam04142:
Pssm-ID: 398009 Cd Length: 315 Bit Score: 124.37 E-value: 2.59e-32
Nucleotide-sugar transporter; This family of membrane proteins transport nucleotide sugars ...
23-374
2.59e-32
Nucleotide-sugar transporter; This family of membrane proteins transport nucleotide sugars from the cytoplasm into Golgi vesicles. Swiss:P78382 transports CMP-sialic acid, Swiss:P78381 transports UDP-galactose and Swiss:Q9Y2D2 transports UDP-GlcNAc.
Pssm-ID: 398009 Cd Length: 315 Bit Score: 124.37 E-value: 2.59e-32
UDP-galactose transporter; The 10-12 TMS Nucleotide Sugar Transporters (TC 2.A.7.10)Nucleotide-sugar transporters (NSTs) are found in the Golgi apparatus and the endoplasmic reticulum of eukaryotic cells. Members of the family have been sequenced from yeast, protozoans and animals. Animals such as C. elegans possess many of these transporters. Humans have at least two closely related isoforms of the UDP-galactose:UMP exchange transporter.NSTs generally appear to function by antiport mechanisms, exchanging a nucleotide-sugar for a nucleotide. Thus, CMP-sialic acid is exchanged for CMP; GDP-mannose is preferentially exchanged for GMP, and UDP-galactose and UDP-N-acetylglucosamine are exchanged for UMP (or possibly UDP). Other nucleotide sugars (e.g., GDP-fucose, UDP-xylose, UDP-glucose, UDP-N-acetylgalactosamine, etc.) may also be transported in exchange for various nucleotides, but their transporters have not been molecularly characterized. Each compound appears to be translocated by its own transport protein. Transport allows the compound, synthesized in the cytoplasm, to be exported to the lumen of the Golgi apparatus or the endoplasmic reticulum where it is used for the synthesis of glycoproteins and glycolipids.
Pssm-ID: 129885 Cd Length: 222 Bit Score: 58.91 E-value: 5.93e-10
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
101-180
1.59e-04
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];
Pssm-ID: 440461 [Multi-domain] Cd Length: 290 Bit Score: 43.29 E-value: 1.59e-04
Nucleotide-sugar transporter; This family of membrane proteins transport nucleotide sugars ...
23-374
2.59e-32
Nucleotide-sugar transporter; This family of membrane proteins transport nucleotide sugars from the cytoplasm into Golgi vesicles. Swiss:P78382 transports CMP-sialic acid, Swiss:P78381 transports UDP-galactose and Swiss:Q9Y2D2 transports UDP-GlcNAc.
Pssm-ID: 398009 Cd Length: 315 Bit Score: 124.37 E-value: 2.59e-32
UDP-galactose transporter; The 10-12 TMS Nucleotide Sugar Transporters (TC 2.A.7.10)Nucleotide-sugar transporters (NSTs) are found in the Golgi apparatus and the endoplasmic reticulum of eukaryotic cells. Members of the family have been sequenced from yeast, protozoans and animals. Animals such as C. elegans possess many of these transporters. Humans have at least two closely related isoforms of the UDP-galactose:UMP exchange transporter.NSTs generally appear to function by antiport mechanisms, exchanging a nucleotide-sugar for a nucleotide. Thus, CMP-sialic acid is exchanged for CMP; GDP-mannose is preferentially exchanged for GMP, and UDP-galactose and UDP-N-acetylglucosamine are exchanged for UMP (or possibly UDP). Other nucleotide sugars (e.g., GDP-fucose, UDP-xylose, UDP-glucose, UDP-N-acetylgalactosamine, etc.) may also be transported in exchange for various nucleotides, but their transporters have not been molecularly characterized. Each compound appears to be translocated by its own transport protein. Transport allows the compound, synthesized in the cytoplasm, to be exported to the lumen of the Golgi apparatus or the endoplasmic reticulum where it is used for the synthesis of glycoproteins and glycolipids.
Pssm-ID: 129885 Cd Length: 222 Bit Score: 58.91 E-value: 5.93e-10
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
101-180
1.59e-04
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];
Pssm-ID: 440461 [Multi-domain] Cd Length: 290 Bit Score: 43.29 E-value: 1.59e-04
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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