|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00108 |
PTZ00108 |
DNA topoisomerase 2-like protein; Provisional |
25-1497 |
0e+00 |
|
DNA topoisomerase 2-like protein; Provisional
Pssm-ID: 240271 [Multi-domain] Cd Length: 1388 Bit Score: 1700.24 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 25 KKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVG-INYREVTFVPGLYKIFDEILVNAADNKQRDP--- 100
Cdd:PTZ00108 1 KKNKTVEERYQKKTQIEHILLRPDTYIGSIETQTEDMWVYDEEKNrMVYKTITYVPGLYKIFDEILVNAADNKARDKggh 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 101 KMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE 180
Cdd:PTZ00108 81 RMTYIKVTIDEENGEISVYNDGEGIPVQIHKEHKIYVPEMIFGHLLTSSNYDDTEKRVTGGRNGFGAKLTNIFSTKFTVE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 181 TASREYKKMFKQTWMDNMGRAGEMELKPFNG-EDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNG 259
Cdd:PTZ00108 161 CVDSKSGKKFKMTWTDNMSKKSEPRITSYDGkKDYTKVTFYPDYAKFGMTEFDDDMLRLLKKRVYDLAGCFGKLKVYLNG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 260 NKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVD 339
Cdd:PTZ00108 241 ERIAIKSFKDYVDLYLPDGEEGKKPPYPFVYTSVNGRWEVVVSLSDGQFQQVSFVNSICTTKGGTHVNYILDQLISKLQE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 340 VVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKA 419
Cdd:PTZ00108 321 KAKKKKKKGKEIKPNQIKNHLWVFVNCLIVNPSFDSQTKETLTTKPSKFGSTCELSEKLIKYVLKSPILENIVEWAQAKL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 420 QVQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHK 499
Cdd:PTZ00108 401 AAELNKKMKAGKKSRILGIPKLDDANDAGGKNSEECTLILTEGDSAKALALAGLSVVGRDYYGVFPLRGKLLNVRDASLK 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 500 QIMENAEINNIIKIVGLQYKKNYEDedsLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHR-FLEEFITPIV 578
Cdd:PTZ00108 481 QLMNNKEIQNLFKILGLDIGKKYED---PKGLRYGSLMIMTDQDHDGSHIKGLLINMIHHFWPSLLKNPgFLKEFITPIV 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 579 KVSK-NKQEMAFYSLPEFEEWKSSTPNhKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQ 657
Cdd:PTZ00108 558 KATKkGNQVISFFTIPDFEKWKQTVGL-KGWKIKYYKGLGTSTDKEGKEYFSNIDKHRIRFVYVDDSDDDSIDLAFSKKR 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 658 IDDRKEWLTNFME----DRRQRKllglpedylygqtttyLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTC 733
Cdd:PTZ00108 637 VEDRKEWITNYKGgtyvDHSKKK----------------LTYSDFVNKELILFSIADNERSIPSLVDGLKPGQRKILFAC 700
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 734 FKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSL 813
Cdd:PTZ00108 701 FKRNLKNEIKVAQLSGYVSEHSAYHHGEQSLQQTIVGMAQNFVGSNNINLLYPCGQFGSRLQGGKDHAAARYIFTKLSKI 780
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 814 ARLLFPPKDDHTLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYK 893
Cdd:PTZ00108 781 TRYIFPEEDDPILDYLEDDGQSVEPFYYVPIIPMVLVNGAEGIGTGFSTSIPNYNPLDIIDNLRRRLNGEEVRPLVPWYR 860
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 894 NFKGTIEELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEqVLEpmlNGTEKTPPLITDYREYHTDTTVKFVVKMT 973
Cdd:PTZ00108 861 GFKGTIERNPKGKFISKGIYEKVPDGTVEITELPIGKWTEDYKE-FLE---SETLKEKDVIVDYRDYSTANTVHFTVKLN 936
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 974 EEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQAR 1053
Cdd:PTZ00108 937 DGVLEQWEEEGIEKVFKLKSTISTTNMVLFDENGKIKKYSDALDILKEFYLVRLDLYKKRKEYLLGKLERELARLSNKVR 1016
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 1054 FILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPL 1133
Cdd:PTZ00108 1017 FIKHVINGELVITNAKKKDLVKELKKLGYVRFKDIIKKKSEKITAEEEEGAEEDDEADDEDDEEELGAAVSYDYLLSMPI 1096
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 1134 WYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVglpgkggkakgkktqmaevlps 1213
Cdd:PTZ00108 1097 WSLTKEKVEKLNAELEKKEKELEKLKNTTPKDMWLEDLDKFEEALEEQEEVEEKEIAK---------------------- 1154
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 1214 prgqrvipritiemkaeaekknkkkiknentegspqedgveleglKQRLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNP 1293
Cdd:PTZ00108 1155 ---------------------------------------------EQRLKSKTKGKASKLRKPKLKKKEKKKKKSSADKS 1189
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 1294 WSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQK 1373
Cdd:PTZ00108 1190 KKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSSEDNDEFSSDDLSKEG 1269
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 1374 SVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPALNSGVSQ 1453
Cdd:PTZ00108 1270 KPKNAPKRVSAVQYSPPPPSKRPDGESNGGSKPSSPTKKKVKKRLEGSLAALKKKKKSEKKTARKKKSKTRVKQASASQS 1349
|
1450 1460 1470 1480
....*....|....*....|....*....|....*....|....
gi 19913406 1454 KPdpaKTKNRRKRKPSTSDDSDsnFEKIVSKAVTSKKSKGESDD 1497
Cdd:PTZ00108 1350 SR---LLRRPRKKKSDSSSEDD--DDSEVDDSEDEDDEDDEDDD 1388
|
|
| PLN03128 |
PLN03128 |
DNA topoisomerase 2; Provisional |
29-1179 |
0e+00 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215593 [Multi-domain] Cd Length: 1135 Bit Score: 1664.46 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 29 SVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYdEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVT 108
Cdd:PLN03128 2 TIEETYQKKTQLEHILLRPDTYIGSTEKHTQTLWVY-EGGEMVNREVTYVPGLYKIFDEILVNAADNKQRDPSMDSLKVD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 109 IDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKK 188
Cdd:PLN03128 81 IDVEQNTISVYNNGKGIPVEIHKEEGVYVPELIFGHLLTSSNFDDNEKKTTGGRNGYGAKLANIFSTEFTVETADGNRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 189 MFKQTWMDNMGRAGEMELKPFNG-EDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAG-STKDVKVFLNGNKLPVKG 266
Cdd:PLN03128 161 KYKQVFTNNMSVKSEPKITSCKAsENWTKITFKPDLAKFNMTRLDEDVVALMSKRVYDIAGcLGKKLKVELNGKKLPVKS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 267 FRSYVDMYLKDKLDEtgNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNK 346
Cdd:PLN03128 241 FQDYVGLYLGPNSRE--DPLPRIYEKVNDRWEVCVSLSDGSFQQVSFVNSIATIKGGTHVDYVADQIVKHIQEKVKKKNK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 347 GGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQVQLnKK 426
Cdd:PLN03128 319 NATHVKPFQIKNHLWVFVNCLIENPTFDSQTKETLTTRPSSFGSKCELSEEFLKKVEKCGVVENILSWAQFKQQKEL-KK 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 427 CSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAE 506
Cdd:PLN03128 398 KDGAKRQRLTGIPKLDDANDAGGKKSKDCTLILTEGDSAKALAMSGLSVVGRDHYGVFPLRGKLLNVREASHKQIMKNAE 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 507 INNIIKIVGLQYKKNYeDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLR-HRFLEEFITPIVKVSKNKQ 585
Cdd:PLN03128 478 ITNIKQILGLQFGKTY-DEENTKSLRYGHLMIMTDQDHDGSHIKGLIINFFHSFWPSLLKiPGFLVEFITPIVKATKGGK 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 586 EMAFYSLPEFEEWKSST-PNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDDRKEW 664
Cdd:PLN03128 557 SLSFYTMPEYEAWKESLeGETKGWTIKYYKGLGTSTSEEAKEYFSNLDIHKKEFLWQSDEDGDLIDMAFSKKRVEDRKIW 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 665 LTNFMEDrrqrkllglpeDYLyGQTTTYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKV 744
Cdd:PLN03128 637 LNNYEPG-----------TFL-DQTGNGISYSDFINKELILFSQADLARSIPSMVDGLKPSQRKVLFACFKRNLKSEIKV 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 745 AQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDH 824
Cdd:PLN03128 705 AQLSGYVAEHSAYHHGEASLASTIIGMAQDFVGSNNINLLTPSGQFGTRLQGGKDAASARYIFTRLSPITRALFPKDDDV 784
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 825 TLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIEELAP 904
Cdd:PLN03128 785 LLNYLNEDGQSIEPEWYCPIIPMVLVNGSEGIGTGWSTFIPNYNPRDIIANIRRLLRGEELEPMHPWYRGFKGTITEVST 864
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 905 ---NQYVISGEVAILNSTTIEISELPVRTWTQTYKEqVLEPMLNGTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAE 981
Cdd:PLN03128 865 srsGSYTVTGIIEQIGDTTIRITELPVRKWTQDYKE-FLEALLTGTKKKEPEIKDFKENHTDTTVHFTVTLSEEKMARAL 943
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 982 RVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDG 1061
Cdd:PLN03128 944 AEGLEKKFKLSTTISTSNMHLFDKDGKIKKYDSPEDILEEFFHLRLDLYVKRKEVLLENLEYELKKLDNKARFILAVVKG 1023
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 1062 KIIIENKPKKELIKVLIQRGYDSDPvkawKEAQQKVPDEEENEESDNEKETEKSDSvtDSGPTFNYLLDMPLWYLTKEKK 1141
Cdd:PLN03128 1024 EIVVNNRKRAELLAELEEKGFDKFP----KTAKISETNVVGDRDGEASEEEEASDN--ELAKSYDYLLGMPISSLTLEKV 1097
|
1130 1140 1150
....*....|....*....|....*....|....*...
gi 19913406 1142 DELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELE 1179
Cdd:PLN03128 1098 DELRAERAKKETEVEELKKTTPEDLWRKDLDAFEEALD 1135
|
|
| PLN03237 |
PLN03237 |
DNA topoisomerase 2; Provisional |
8-1480 |
0e+00 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215641 [Multi-domain] Cd Length: 1465 Bit Score: 1492.82 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 8 PVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINyREVTFVPGLYKIFDE 87
Cdd:PLN03237 6 PLQESNSANVAAAPAASSGGKTIEEMYQKKSQLEHILLRPDTYIGSIEKHTQTLWVYETDKMVQ-RSVTYVPGLYKIFDE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 88 ILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGA 167
Cdd:PLN03237 85 ILVNAADNKQRDPKMDSLRVVIDVEQNLISVYNNGDGVPVEIHQEEGVYVPEMIFGHLLTSSNYDDNEKKTTGGRNGYGA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 168 KLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGE-MELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDI 246
Cdd:PLN03237 165 KLTNIFSTEFVIETADGKRQKKYKQVFSNNMGKKSEpVITKCKKSENWTKVTFKPDLAKFNMTHLEDDVVALMKKRVVDI 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 247 AGST-KDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRH 325
Cdd:PLN03237 245 AGCLgKTVKVELNGKRIPVKSFSDYVDLYLESANKSRPENLPRIYEKVNDRWEVCVSLSEGQFQQVSFVNSIATIKGGTH 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 326 VDYVADQIVTKLVDVVKKKNKGGvAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGC 405
Cdd:PLN03237 325 VDYVTNQIANHVMEAVNKKNKNA-NIKAHNVKNHLWVFVNALIDNPAFDSQTKETLTLRQSSFGSKCELSEDFLKKVMKS 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 406 GIVESILNWVKFKAQVQLnKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFP 485
Cdd:PLN03237 404 GIVENLLSWADFKQSKEL-KKTDGAKTTRVTGIPKLEDANEAGGKNSEKCTLILTEGDSAKALAVAGLSVVGRNYYGVFP 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 486 LRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEdedSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLL 565
Cdd:PLN03237 483 LRGKLLNVREASHKQIMNNAEIENIKQILGLQHGKQYE---SVKSLRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLL 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 566 R-HRFLEEFITPIVKVSK-NKQEMAFYSLPEFEEWKSS-TPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSG 642
Cdd:PLN03237 560 KvPSFLVEFITPIVKATRrGKKVLSFYSMPEYEEWKESlGGNATGWSIKYYKGLGTSTAKEGKEYFKNLGKHKKDFVWED 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 643 PEDDAAISLAFSKKQIDDRKEWLTNFMedrrqrkllglPEDYLyGQTTTYLTYNDFINKELILFSNSDNERSIPSMVDGL 722
Cdd:PLN03237 640 EQDGDAIELAFSKKKIEARKNWLRQYE-----------PGTHL-DQTQKDVKYSDFVNKELILFSMADLQRSIPSMVDGL 707
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 723 KPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSAS 802
Cdd:PLN03237 708 KPGQRKILFCSFKRNFVKEAKVAQLSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRLQGGKDHAS 787
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 803 PRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDG 882
Cdd:PLN03237 788 ARYIFTRLSPITRFLFPKDDDILLDYLNEDGQSIEPTWYMPIIPTVLVNGAEGIGTGWSTFIPNYNPRDIVANIRRLLNG 867
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 883 EEPLPMLPSYKNFKGTIEELAPNQ----YVISGEVAILNSTTIEISELPVRTWTQTYKEqVLEPMLNGTEKTP-PLITDY 957
Cdd:PLN03237 868 ESMEPMHPWYRGFKGTIEKTASKEggctYTITGLYEEVDETTLRITELPIRRWTDDYKE-FLESLKTDNNKNKdPFIKDV 946
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 958 REYHTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWL 1037
Cdd:PLN03237 947 KAYNDDTTVHFEVILSEENMLAAKQEGLLKKFKLTTTISTSNMHLFDSKGVIKKYDTPEQILEEFFHLRLEYYEKRKEVL 1026
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 1038 LGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAwKEAQQKVPDEEENEESDNEKETEKSDS 1117
Cdd:PLN03237 1027 LKNLEFELLKLENKVRFILAVVDGEIIVNNRKKADLVEELRQKGFTPFPKKA-KSVEAAVAGATDDAAEEEEEIDVSSSS 1105
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 1118 VTDsGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKG 1197
Cdd:PLN03237 1106 GVR-GSDYDYLLSMAIGTLTLEKVQELCADRDKLNIEVEDLKKTTPKSLWLKDLDALEKELDKLDKEDAKAEEAREKLQR 1184
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 1198 GKAkgkktqMAEVLPSPRGQRVIPRitiemkaeaekknKKKIKNENTEGSPQEDGVELEGlKQRLEKKQKREPGTKTKKQ 1277
Cdd:PLN03237 1185 AAA------RGESGAAKKVSRQAPK-------------KPAPKKTTKKASESETTEETYG-SSAMETENVAEVVKPKGRA 1244
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 1278 TTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPP-----RETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSD 1352
Cdd:PLN03237 1245 GAKKKAPAAAKEKEEEDEILDLKDRLAAYNLDSAPaqsakMEETVKAVPARRAAARKKPLASVSVISDSDDDDDDFAVEV 1324
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 1353 ASPPKTK---------------TSPKLSNKELKPQKSVVSDLEADDVKGSVPLSSSPpathfpdETEI----TNPVPKKN 1413
Cdd:PLN03237 1325 SLAERLKkkggrkpaaankkaaKPPAAAKKRGPATVQSGQKLLTEMLKPAEAIGISP-------EKKVrkmrASPFNKKS 1397
|
1450 1460 1470 1480 1490 1500
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19913406 1414 VTVKKTAAKSQSSTSTTGAkkrAAPKGTKRDPAlnsGVSQKPDPAktknRRKRKPSTSDDSDSNFEK 1480
Cdd:PLN03237 1398 GSVLGRAATNKETESSENV---SGSSSSEKDEI---DVSAKPRPQ----RANRKQTTYVLSDSESES 1454
|
|
| TOP2c |
smart00433 |
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE |
80-669 |
0e+00 |
|
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE
Pssm-ID: 214659 [Multi-domain] Cd Length: 594 Bit Score: 777.89 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 80 GLYKIFDEILVNAADNKQRDPkMSCIRVTIDPENnLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVT 159
Cdd:smart00433 1 GLHHLVDEIVDNAADEALAGY-MDTIKVTIDKDN-SISVEDNGRGIPVEIHPKEKKYAPEVIFTVLHAGGKFDDDAYKVS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 160 GGRNGYGAKLCNIFSTKFTVETASReyKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSldKDIVALM 239
Cdd:smart00433 79 GGLHGVGASVVNALSTEFEVEVARD--GKEYKQSFSNNGKPLSEPKIIGDTKKDGTKVTFKPDLEIFGMTT--DDDFELL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 240 VRRAYDIAGSTKDVKVFLNGNK-------LPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKG-FQQI 311
Cdd:smart00433 155 KRRLRELAFLNKGVKITLNDERsdeektfLFEGGIKDYVELLNKNKELLSPEPTYIEGEKDNIRVEVAFQYTDGYsENIV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 312 SFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVA-VKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFG- 389
Cdd:smart00433 235 SFVNNIATTEGGTHENGFKDALTRVINEYAKKKKKLKEKnIKGEDVREGLTAFISVKIPEPQFEGQTKEKLGTSEVRFGv 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 390 ----STCQLSEKFIKAAIGCGIVESILNWVKFKAQVQ-LNKKCSAVKHNRIKGIPKLDDANDAGGRnstECTLILTEGDS 464
Cdd:smart00433 315 ekivSECLLSFLEENPVEASKIVEKVLLAAKARAAAKkARELTRKKKLSSISLPGKLADASSAGPK---KCELFLVEGDS 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 465 AKTLAVSGLgvvGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYededSLKTLRYGKIMIMTDQDQ 544
Cdd:smart00433 392 AGGSAKSGR---DRDFQAILPLRGKILNVEKASLDKILKNEEIQALITALGLGIGKDF----DIEKLRYGKIIIMTDADV 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 545 DGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQ--EMAFYSLPEFEEWKSSTPNHK-KWKVKYYKGLGTSTS 621
Cdd:smart00433 465 DGSHIKGLLLTFFYRYMPPLIEAGFVYIAIPPLYKVTKGKKkyVYSFYSLDEYEKWLEKTEGNKsKYEIQRYKGLGEMNA 544
|
570 580 590 600
....*....|....*....|....*....|....*....|....*....
gi 19913406 622 KEAKEYFADMKRHRIQFKYSGPEDDA-AISLAFSKKQIDDRKEWLTNFM 669
Cdd:smart00433 545 DQLWETTMDPERRTLLFVTLDDADEAdLIFSALMGDKVEPRKEWIEENA 593
|
|
| TOP4c |
smart00434 |
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC |
693-1169 |
0e+00 |
|
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
Pssm-ID: 214660 [Multi-domain] Cd Length: 444 Bit Score: 566.81 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 693 LTYNDFINKELILFSNS-DNERSIPSMVDGLKPGQRKVLFTCFKRNDKR-EVKVAQLAGSVAEMSSYH-HGEMSLMMTII 769
Cdd:smart00434 1 IDIEDFINKEYLDYSMSvINGRAIPDVRDGLKPVQRRILYAMFKRGLTPdEPKVKSARGVGDVMGKYHpHGDSSLYDTIV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 770 NLAQNFVgsNNLNLLQPIGQFGTRLhGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYD-DNQRVEPEWYIPIIPMV 848
Cdd:smart00434 81 RMAQDFS--NNYPLLDGQGNFGSRL-DGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNyDGQEIEPTVLPPIIPNL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 849 LINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEP----LPMLPSYKNFKGTIEELAPNQYVISGEVAILNSTTIEIS 924
Cdd:smart00434 158 LVNGSSGIAVGMATNIPPHNLREVIDAVRRLIDNPDAsideLMMIPWGPDFPTGGEIVGPGKYVVRGKIEIEDDNTIVIT 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 925 ELPVRTWTQTYKEQVLEPMLNGteKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFD 1004
Cdd:smart00434 238 ELPYQVNTADLIEKIAELVKDK--KIEGIIDVRDESHDRTGVRIVIELKRGAMAEVVLNGLYKLTKLQTTFSINMLALFD 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 1005 HvGCLKKYDTVlDILRDFFELRLKYYGLRKEWLLGMLGAEsAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDS 1084
Cdd:smart00434 316 N-GRPKKYNLK-EILKEFLDHRLEVYTRRKEYLLGKLEAE-RLHILEGLFIALSIIDEIIVLIRSSKDLAKEAKEKLMER 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 1085 dpvkawkeaqqkvpdeeeneesdneketeksdsVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPS 1164
Cdd:smart00434 393 ---------------------------------FELSEIQADAILDMRLRRLTKLEVEKLEKELKELEKEIEDLEKILAS 439
|
....*
gi 19913406 1165 DLWKE 1169
Cdd:smart00434 440 EEWLN 444
|
|
| TOP4c |
cd00187 |
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ... |
711-1174 |
1.05e-170 |
|
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.
Pssm-ID: 238111 [Multi-domain] Cd Length: 445 Bit Score: 519.82 E-value: 1.05e-170
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 711 NERSIPSMVDGLKPGQRKVLFTCFKRN---DKREVKVAQLAGSVAEMSsYHHGEMSLMMTIINLAQNFvgSNNLNLLQPI 787
Cdd:cd00187 1 NGRALPDVRDGLKPVQRRILYAMFKRGltpDKPEKKVARLVGDVAGKY-HPHGDSSLYDTIVRMAQDF--SNNIPLLDPQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 788 GQFGTRlhGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYD-DNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPN 866
Cdd:cd00187 78 GNFGSR--DGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNyDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 867 FDVREIVNNIRRLMDGEEP-------LPMLPSYKNFkGTIEELA---------PNQYVISGEVAIL---NSTTIEISELP 927
Cdd:cd00187 156 HNLREVIDALRALIDNPEAsidelmeIIKGPDFPTG-GIIEGRAgireayetgRGRYIIRGKYEIEddeGRNTIEITELP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 928 VRTWTQTYKEQVLEPMlngTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNsMVLFDHVG 1007
Cdd:cd00187 235 YQVNKAKLKEKIAELV---KDKKIEGISDVRDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQTTFGIN-MVAFDPNG 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 1008 CLKKYdTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKID--GKIIIENKPKKELIKVLIQRGYDSD 1085
Cdd:cd00187 311 RPKKL-NLKEILQEFLDHRLEVYTRRKEYELGKAEARLHILEGLLKAILNIDEviNLIRSSDEAKKALIEELEKLGFSEI 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 1086 pvkawkeaqqkvpdeeeneesdneketeksdsvtdsgpTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKS--- 1162
Cdd:cd00187 390 --------------------------------------QADAILDMRLRRLTKLEREKLLKELKELEAEIEDLEKILase 431
|
490
....*....|....
gi 19913406 1163 --PSDLWKEDLATF 1174
Cdd:cd00187 432 erPKDLWKEELDEF 445
|
|
| DNA_topoisoIV |
pfam00521 |
DNA gyrase/topoisomerase IV, subunit A; |
713-1171 |
3.18e-158 |
|
DNA gyrase/topoisomerase IV, subunit A;
Pssm-ID: 459843 [Multi-domain] Cd Length: 432 Bit Score: 486.29 E-value: 3.18e-158
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 713 RSIPSMVDGLKPGQRKVLFTCFK--RNDKREVKVAQLAGSVaeMSSYH-HGEMSLMMTIINLAQNFVGsnNLNLLQPIGQ 789
Cdd:pfam00521 1 RAIPDVRDGLKPVQRRILYAMFEllNLDKPYKKVARLVGDV--MGKYHpHGDASLYDAIVRMAQDFVG--NIPLLDGQGN 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 790 FGTRLHGGKDsASPRYIFTMLSSLARLLFPPKDDHTLKFLYD-DNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFD 868
Cdd:pfam00521 77 FGSRIDGDKD-AAMRYTETRLSKIARELFPDIDDDTVDYVPNyDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 869 VREIVNNIRRLMDGEEP-----LPMLPSYKNFKGTIEELAP--------NQYVISGEVAILNSTTIEISELPVRTWTQTY 935
Cdd:pfam00521 156 LREIIDALIALLDGPEAtllmkYIMGPDFPTGGGIIGKGGIkeayktgrGKITVRAKVEIEDRKTIVITELPYGVWTSDL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 936 KEQvLEPMLNgtEKTPPLITDYREYhTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVgclKKYDTV 1015
Cdd:pfam00521 236 IEK-IEELVK--NGKIKGISDIRDE-SDRGVRIVIELKRGADPEVVLNDLYKKTKLQTSFSTNNLVLFDGG---PKYLGL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 1016 LDILRDFFELRLKYYGLRKEWLLGMLGAESAKLN------NQARFILEKIDGKiIIENKPKKELIKVLiqrgydsdpvka 1089
Cdd:pfam00521 309 KEILKEFLDHRLEVYERRKEYLLEKLEERLHILEgllialNNIDFVIEIIRGS-IDRKKAKKNLIEEL------------ 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 1090 wKEAQqkvpdeeeneesdneketeksdsvtdsgptFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPS----- 1164
Cdd:pfam00521 376 -SEIQ------------------------------ADYLLDMRLRRLTKEEVDKLLEEIDELEKEIAELEKLLASekkln 424
|
....*..
gi 19913406 1165 DLWKEDL 1171
Cdd:pfam00521 425 DLWIEEL 431
|
|
| HATPase_TopII-like |
cd16930 |
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the ... |
77-222 |
5.57e-96 |
|
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the histidine kinase-like ATPase (HATpase) domains of human topoisomerase IIA (TopIIA) and TopIIB, Saccharomyces cerevisae TOP2p, and related proteins. These proteins catalyze the passage of DNA double strands through a transient double-strand break in the presence of ATP.
Pssm-ID: 340407 [Multi-domain] Cd Length: 147 Bit Score: 305.03 E-value: 5.57e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 77 FVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEK 156
Cdd:cd16930 1 YVPGLYKIFDEILVNAADNKQRDKSMTCIKVTIDPENNEISVWNNGKGIPVVIHKEEKIYVPEMIFGHLLTSSNYDDDEK 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19913406 157 KVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPF-NGEDYTCITFQPD 222
Cdd:cd16930 81 KVTGGRNGYGAKLCNIFSTEFTVETADSESKKKFKQTWTNNMGKASEPKITPYeKGKDYTKVTFKPD 147
|
|
| TopoIIA_Trans_ScTopoIIA |
cd03481 |
TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the ... |
265-417 |
7.37e-89 |
|
TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded by a single gene. The type IIA enzymes are the predominant form of topoisomerase and are found in some bacteriophages, viruses and archaea, and in all bacteria and eukaryotes. All type IIA topoisomerases are related to each other at amino acid sequence level, though their oligomeric organization sometimes differs. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. TopoIIA enzymes also catenate/ decatenate duplex rings. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes.
Pssm-ID: 239563 [Multi-domain] Cd Length: 153 Bit Score: 285.33 E-value: 7.37e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 265 KGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKK 344
Cdd:cd03481 1 KSFKDYVKLYLKDANKEDGPPPPVVYEPVNDRWEVAVALSDGQFQQVSFVNSIATTKGGTHVDYVADQIVKKLDEVVKKK 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19913406 345 NKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKF 417
Cdd:cd03481 81 NKGGINVKPFQVKNHLWIFVNCLIENPSFDSQTKETLTTKPKSFGSKCELSEKFLKKAVKSGIVESVLSWAKF 153
|
|
| 39 |
PHA02569 |
DNA topoisomerase II large subunit; Provisional |
41-666 |
7.36e-85 |
|
DNA topoisomerase II large subunit; Provisional
Pssm-ID: 177398 [Multi-domain] Cd Length: 602 Bit Score: 290.89 E-value: 7.36e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 41 EHILLRPDTYIGSVELVTQQMWVYDedvgiNYREVTFVPGLYKIFDEILVNAADNKQR-DPKMS-CIRVTIDpeNNLISI 118
Cdd:PHA02569 11 EHILKRPGMYIGSVAYEAHERFLFG-----KFTQVEYVPGLVKIIDEIIDNSVDEAIRtNFKFAnKIDVTIK--NNQVTV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 119 WNNGKGIP---VVEHKVEKMYVPALIFGQLLTSSNYDDDEKkVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQT-W 194
Cdd:PHA02569 84 SDNGRGIPqamVTTPEGEEIPGPVAAWTRTKAGSNFDDTNR-VTGGMNGVGSSLTNFFSVLFIGETCDGKNEVTVNCSnG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 195 MDNMGrageMELKPfNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKgFRSYVDMY 274
Cdd:PHA02569 163 AENIS----WSTKP-GKGKGTSVTFIPDFSHFEVNGLDQQYLDIILDRLQTLAVVFPDIKFTFNGKKVSGK-FKKYAKQF 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 275 LKDKldetgnslkVIHEqvNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKggVAVKAH 354
Cdd:PHA02569 237 GDDT---------IVQE--NDNVSIALAPSPDGFRQLSFVNGLHTKNGGHHVDCVMDDICEELIPMIKKKHK--IEVTKA 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 355 QVKN--HMWIFVNALIeNPTFDSQTKENMTLQPKSFGSTCQLSEKFI------KAAIGCGIVESIL--NWVKFKAQVQLN 424
Cdd:PHA02569 304 RVKEclTIVLFVRNMS-NPRFDSQTKERLTSPFGEIRNHIDLDYKKIakqilkTEAIIMPIIEAALarKLAAEKAAETKA 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 425 KKcSAVKHNRIKGIPklddANDAGgrNSTECTLILTEGDSAKTLAVSglgVVGRDKYGVFPLRGKILNVREASHKQIMEN 504
Cdd:PHA02569 383 AK-KAKKAKVAKHIK----ANLIG--KDAETTLFLTEGDSAIGYLIE---VRDEELHGGYPLRGKVLNTWGMSYADILKN 452
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 505 AEINNIIKIVGLQYKknyEDEDSLKtlrYGKIMIMTDQDQDG-SHIKGLLINFIhHNWPSLL---RHRFLEefiTPIVKV 580
Cdd:PHA02569 453 KELFDICAITGLVLG---EKAENMN---YKNIAIMTDADVDGkGSIYPLLLAFF-SRWPELFeqgRIRFVK---TPVIIA 522
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 581 SKNKQEMAFYSLPEFEEWKSStpnHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEddaAISLAFSKKQiDD 660
Cdd:PHA02569 523 QVGKETKWFYSLDEFEKAKDS---LKKWSIRYIKGLGSLRKSEYRRVINNPVYDVVVLPDDWKE---LFEMLFGDDA-DL 595
|
....*.
gi 19913406 661 RKEWLT 666
Cdd:PHA02569 596 RKDWMS 601
|
|
| TOPRIM_TopoIIA |
cd03365 |
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the ... |
455-575 |
1.61e-77 |
|
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173785 [Multi-domain] Cd Length: 120 Bit Score: 251.45 E-value: 1.61e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 455 CTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKnyEDEDSLKTLRYG 534
Cdd:cd03365 1 CTLILTEGDSAKALAVAGLSVVGRDYYGVFPLRGKLLNVREASHKQIMENAEIQNIKKILGLQHGK--SDYESTKSLRYG 78
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 19913406 535 KIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHR-FLEEFIT 575
Cdd:cd03365 79 RLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKIPgFLVEFIT 120
|
|
| 52 |
PHA02592 |
DNA topisomerase II medium subunit; Provisional |
691-1179 |
3.00e-77 |
|
DNA topisomerase II medium subunit; Provisional
Pssm-ID: 222896 [Multi-domain] Cd Length: 439 Bit Score: 263.46 E-value: 3.00e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 691 TYLTYNDFINKELILFSNSD-NERSIPSMVDGLKPGQRKVLFTC--FKRNDKREV-KVAQLAGSVAEMSsYHHGEMSLMM 766
Cdd:PHA02592 4 KERSLKSIVNNEALEYAMYTvEERAIPNLIDGLKPVQRFVIHRAleYAKGNKEKFdKVAAIAGGVADLG-YHHGETSAQD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 767 TIINLAQNFvgSNNLNLLQPIGQFGTRLhgGKDSASPRYIFTMLSSLARLLFppKDDHtLKFLYDDNQRVEPEWYIPIIP 846
Cdd:PHA02592 83 AGALMANTW--NNNIPLLDGQGNFGSRL--VQKAAAARYIFARVHDNFRKIY--KDED-LAPVHEDPEHIPPAFYLPIIP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 847 MVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIEELAPNQYVISGEVAILNSTTIEISEL 926
Cdd:PHA02592 156 MVLLNGVSGIATGYATNILPHSPKSVIKAVLAALNGKDITEPKVQFPEFKGEVVEIEPGSYEIRGTYELNGKTKLHITEI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 927 PVRTWTQTYKEqVLEPMLngtEKTppLITDYREYHTDtTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLfDHV 1006
Cdd:PHA02592 236 PVKYDRETYVA-VLDPLE---EKG--KIVSYDDCTED-GFRFKVTLKREENEEATHEKIMKDFGLIERVSQNITVI-NEN 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 1007 GCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLiqrgydsdp 1086
Cdd:PHA02592 308 GKLKVYENAEDLIRDFVEIRKTYVQKRIQYEIKETEEAFDLALAKAEFIKRVIAGEIVLQGKTRSELTEEL--------- 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 1087 vKAWKeaqqkvpdeeeneesdneketeksdsvtDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDL 1166
Cdd:PHA02592 379 -SDNK----------------------------DFGEYADKLVAMNIYSMTSDEREKLQKEAEELEKEHEYWKKTTAKKE 429
|
490
....*....|...
gi 19913406 1167 WKEDLatfiEELE 1179
Cdd:PHA02592 430 YIKDL----EELK 438
|
|
| TOPRIM_C |
pfam16898 |
C-terminal associated domain of TOPRIM; TOPRIM_C is found as the C-terminal extension of the ... |
573-711 |
1.38e-75 |
|
C-terminal associated domain of TOPRIM; TOPRIM_C is found as the C-terminal extension of the TOPRIM domain, pfam01751 in metazoa.
Pssm-ID: 465302 [Multi-domain] Cd Length: 127 Bit Score: 246.28 E-value: 1.38e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 573 FITPIVKVSKNKQEMAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLA 652
Cdd:pfam16898 1 FITPIVKVTKGKEVISFFSLPEYEEWKESTPNLKGWKIKYYKGLGTSTSEEAKEYFSNLDKHRKEFKYLGDDDDEAIDLA 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 19913406 653 FSKKQIDDRKEWLTNFMedrrqrkllglPEDYLYgQTTTYLTYNDFINKELILFSNSDN 711
Cdd:pfam16898 81 FSKKKADDRKEWLRNFN-----------PGTYLD-HSTKEISYSDFINKELILFSMADN 127
|
|
| TOPRIM_TopoIIA_like |
cd01030 |
TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain ... |
455-575 |
2.57e-63 |
|
TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173780 [Multi-domain] Cd Length: 115 Bit Score: 210.44 E-value: 2.57e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 455 CTLILTEGDSAKTLAVSGLGVVgrdKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDedsLKTLRYG 534
Cdd:cd01030 1 CELILVEGDSAGGSAKQGRDRV---FQAVFPLRGKILNVEKASLKKILKNEEIQNIIKALGLGIGKDDFD---LDKLRYG 74
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 19913406 535 KIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFIT 575
Cdd:cd01030 75 KIIIMTDADVDGSHIRTLLLTFFYRFWPSLLENGFLYIAQT 115
|
|
| PRK05559 |
PRK05559 |
DNA topoisomerase IV subunit B; Reviewed |
40-617 |
9.33e-54 |
|
DNA topoisomerase IV subunit B; Reviewed
Pssm-ID: 235501 [Multi-domain] Cd Length: 631 Bit Score: 200.33 E-value: 9.33e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 40 LEHILLRPDTYIGSvelvtqqmwvYDEDvginyrevtfvpGLYKIFDEILVNAAD-------NKqrdpkmscIRVTIDpE 112
Cdd:PRK05559 19 LEPVRKRPGMYIGS----------TDTR------------GLHHLVQEVIDNSVDealaghgKR--------IEVTLH-A 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 113 NNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETAsREyKKMFKQ 192
Cdd:PRK05559 68 DGSVSVRDNGRGIPVGIHPEEGKSGVEVILTKLHAGGKFSNKAYKFSGGLHGVGVSVVNALSSRLEVEVK-RD-GKVYRQ 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 193 TWmDNMGRAGEMEL--KPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRR-AYDIAGstkdVKVFLNGNKLPVKgFRS 269
Cdd:PRK05559 146 RF-EGGDPVGPLEVvgTAGKRKTGTRVRFWPDPKIFDSPKFSPERLKERLRSkAFLLPG----LTITLNDERERQT-FHY 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 270 yvDMYLKDKLDETGNSLKVIHEQVNHRW---------EVCLTMSEKGFQQI-SFVNSIATSKGGRHVDYVADQIVTKLVD 339
Cdd:PRK05559 220 --ENGLKDYLAELNEGKETLPEEFVGSFegeaegeavEWALQWTDEGGENIeSYVNLIPTPQGGTHENGFREGLLKAVRE 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 340 VVKKKN--KGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMtlqpksfGST-CQ-LSEKFIKAAIG------CGIVE 409
Cdd:PRK05559 298 FAEKRNllPKGKKLEGEDVREGLAAVLSVKIPEPQFEGQTKEKL-------GSReARrFVSGVVKDAFDlwlnqnPELAE 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 410 SILNWVKFKAQVQLNKKCSAVKHNRIKGI---PKLddaNDAGGRNSTECTLILTEGDSAktlavSGLGVVGRDKY--GVF 484
Cdd:PRK05559 371 KLAEKAIKAAQARLRAAKKVKRKKKTSGPalpGKL---ADCTSQDPERTELFLVEGDSA-----GGSAKQARDREfqAIL 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 485 PLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDslktLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSL 564
Cdd:PRK05559 443 PLRGKILNTWEASLDDVLANEEIHDIIVAIGIGPGDSFDLED----LRYGKIIIMTDADVDGAHIATLLLTFFYRHFPPL 518
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*.
gi 19913406 565 LR--HRFLEEfiTPIVKVSKNKQEMAFYSLPEFEEW-KSSTPNHKKWKVKYYKGLG 617
Cdd:PRK05559 519 VEagHVYIAL--PPLYRVDKGKKKIYALDEEEKEELlKKLGKKGGKPEIQRFKGLG 572
|
|
| GyrB |
COG0187 |
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair]; |
40-617 |
2.31e-40 |
|
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];
Pssm-ID: 439957 [Multi-domain] Cd Length: 635 Bit Score: 159.81 E-value: 2.31e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 40 LEHILLRPDTYIGSVelvtqqmwvyDEDvginyrevtfvpGLYKIFDEILVNA--------ADNkqrdpkmscIRVTIDp 111
Cdd:COG0187 17 LEAVRKRPGMYIGST----------DER------------GLHHLVWEIVDNSidealagyCDR---------IEVTLH- 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 112 ENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETAsREyKKMFK 191
Cdd:COG0187 65 ADGSVTVEDNGRGIPVDIHPKEGKSALEVVLTVLHAGGKFDGGSYKVSGGLHGVGASVVNALSERLEVEVK-RD-GKIYR 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 192 QTWMDnmGRAGEmELKpfNGEDY----TCITFQPDLSKFKMQSLDKDIVALMVRRaydiagstkdvKVFLNGN------- 260
Cdd:COG0187 143 QRFER--GKPVG-PLE--KIGKTdrtgTTVRFKPDPEIFETTEFDYETLAERLRE-----------LAFLNKGltitltd 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 261 ---KLPVK-------GFRSYVDMYLKDKldetgnslKVIHEQV--------NHRWEVCLTMSEKGFQQI-SFVNSIATSK 321
Cdd:COG0187 207 ereEEPKEetfhyegGIKDFVEYLNEDK--------EPLHPEViyfegekdGIEVEVALQWNDGYSENIhSFVNNINTPE 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 322 GGRHV------------DYVadqivtKLVDVVKKKNK---------GGVAVkahqvknhmwifVNALIENPTFDSQTKEn 380
Cdd:COG0187 279 GGTHEtgfrtaltrvinDYA------RKNGLLKEKDKnltgddvreGLTAV------------ISVKLPEPQFEGQTKT- 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 381 mtlqpksfgstcQLSEKFIKaaigcGIVESILN----------------WVKF-----------KAQVQLNKKCSAVKHN 433
Cdd:COG0187 340 ------------KLGNSEAR-----GIVESVVSeklehyleenpaeakkILEKailaarareaaRKARELVRRKSALESS 402
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 434 RIKGipKLDDANDaggRNSTECTLILTEGDSA----KTlavsglgvvGRD-KY-GVFPLRGKILNVREASHKQIMENAEI 507
Cdd:COG0187 403 GLPG--KLADCSS---KDPEESELFIVEGDSAggsaKQ---------GRDrEFqAILPLRGKILNVEKARLDKILKNEEI 468
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 508 NNIIKIVGLQYKKNYEDEDslktLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLeeFI--TPIVKVSKNKQ 585
Cdd:COG0187 469 RDLITALGTGIGDDFDLEK----LRYHKIIIMTDADVDGAHIRTLLLTFFYRYMRPLIEAGHV--YIaqPPLYRIKKGKK 542
|
650 660 670
....*....|....*....|....*....|..
gi 19913406 586 EMAFYSLPEFEEWKSSTPNHKKWKVKYYKGLG 617
Cdd:COG0187 543 TYYAYSDAELDELLKELKGKKKVEIQRYKGLG 574
|
|
| gyrB |
PRK05644 |
DNA gyrase subunit B; Validated |
40-617 |
5.97e-35 |
|
DNA gyrase subunit B; Validated
Pssm-ID: 235542 [Multi-domain] Cd Length: 638 Bit Score: 143.31 E-value: 5.97e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 40 LEHILLRPDTYIGSVE------LVTQqmwVYDEDVginyrevtfvpglykifDEILVNAADNkqrdpkmscIRVTIDPeN 113
Cdd:PRK05644 19 LEAVRKRPGMYIGSTGerglhhLVYE---IVDNSI-----------------DEALAGYCDH---------IEVTINE-D 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 114 NLISIWNNGKGIPVVEHKVEKmyVPAL--IFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETaSREYKKmFK 191
Cdd:PRK05644 69 GSITVTDNGRGIPVDIHPKTG--KPAVevVLTVLHAGGKFGGGGYKVSGGLHGVGVSVVNALSTWLEVEV-KRDGKI-YY 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 192 QTWMDnmGR-AGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVAlmvRRAYDIAGSTKDVKVFL----NGNKLPVK- 265
Cdd:PRK05644 145 QEYER--GVpVTPLEVIGETDETGTTVTFKPDPEIFETTEFDYDTLA---TRLRELAFLNKGLKITLtderEGEEKEETf 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 266 ----GFRSYVDmYL-KDKldetgnslKVIHEQV--------NHRWEVCLTMSEkGFQQ--ISFVNSIATSKGGRHVD--Y 328
Cdd:PRK05644 220 hyegGIKEYVE-YLnRNK--------EPLHEEPiyfegekdGIEVEVAMQYND-GYSEniLSFANNINTHEGGTHEEgfK 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 329 VAdqiVTKLV-DVVKKKNK---------------GGVAVKAhqVKnhmwifvnalIENPTFDSQTK------ENMTLQPK 386
Cdd:PRK05644 290 TA---LTRVInDYARKNKLlkekddnltgedvreGLTAVIS--VK----------HPEPQFEGQTKtklgnsEVRGIVDS 354
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 387 SFGStcQLSEKF------IKAaigcgIVESILNwvKFKAQVqlnkkcsAVKHNR----------IKGIP-KLDDANDagg 449
Cdd:PRK05644 355 VVSE--ALSEFLeenpnvAKK-----IVEKAIL--AARARE-------AARKAReltrrksaleSSSLPgKLADCSS--- 415
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 450 RNSTECTLILTEGDSAKTLAVSGlgvvgRDKY--GVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKknyeDEDS 527
Cdd:PRK05644 416 KDPEESELYIVEGDSAGGSAKQG-----RDRRfqAILPLRGKILNVEKARLDKILKNEEIRALITALGTGIG----DDFD 486
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 528 LKTLRYGKIMIMTDQDQDGSHIKGLLINFIhhnwpsllrHRFLEEFIT---------PIVKVSKNKQEMAfYSLPEFEEW 598
Cdd:PRK05644 487 ISKLRYHKIIIMTDADVDGAHIRTLLLTFF---------YRYMRPLIEagyvyiaqpPLYKIKKGGKEYA-YSDEELDEI 556
|
650 660
....*....|....*....|.
gi 19913406 599 KSSTPNH--KKWKVKYYKGLG 617
Cdd:PRK05644 557 LAELKLKgnPKYGIQRYKGLG 577
|
|
| DTHCT |
pfam08070 |
DTHCT (NUC029) region; The DTCHT region is the C-terminal part of DNA gyrases B / ... |
1435-1522 |
7.11e-34 |
|
DTHCT (NUC029) region; The DTCHT region is the C-terminal part of DNA gyrases B / topoisomerase IV / HATPase proteins. This region is composed of quite low complexity sequence.
Pssm-ID: 462355 [Multi-domain] Cd Length: 97 Bit Score: 125.64 E-value: 7.11e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 1435 RAAPKGTKR------DPALNSGVSQKPDPAKTKNRRKRKPSTS-DDSDSNFEKIVSKAVTSKKSKG--ESDDFHMDFDSA 1505
Cdd:pfam08070 1 KAAPKAAKAadksssDSDSDAGASKKPAPPKGRKARKRKPSSSsDDSDSDFGKKPSKAVAKKKSKKvsDDDDFSVDLDSE 80
|
90
....*....|....*..
gi 19913406 1506 VAPRAKSVRAKKPIKYL 1522
Cdd:pfam08070 81 VAPRARPGRAKKPVKYL 97
|
|
| DNA_gyraseB |
pfam00204 |
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal ... |
266-426 |
2.43e-31 |
|
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal S5 domain 2-like fold. This family is structurally related to PF01119.
Pssm-ID: 425522 [Multi-domain] Cd Length: 173 Bit Score: 121.57 E-value: 2.43e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 266 GFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTM---SEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVK 342
Cdd:pfam00204 1 GLKDFVEELNKDKKPLHKEIIYFEGESPDNRIEVEVALqwtDSYSENILSFVNNIATPEGGTHVDGFKSALTRTINEYAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 343 KKN---KGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGC-GIVESILNWVKFK 418
Cdd:pfam00204 81 KKGllkKKDEKITGEDIREGLTAVVSVKIPDPQFEGQTKEKLGNPEVKSAVEKIVSEKLEEFLEENpEIAKKILEKALQA 160
|
....*...
gi 19913406 419 AQVQLNKK 426
Cdd:pfam00204 161 AKARLAAR 168
|
|
| PRK09631 |
PRK09631 |
DNA topoisomerase IV subunit A; Provisional |
712-1073 |
5.37e-24 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 236598 [Multi-domain] Cd Length: 635 Bit Score: 109.03 E-value: 5.37e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 712 ERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGsvaEMSSYH-HGEMSLMMTIINLAqnfvgsNNLNLLQPIGQF 790
Cdd:PRK09631 22 DRAIPDVIDGLKPVQRRILHSLFEMHDGKFHKVANVVG---NTMKYHpHGDASIYEALVNLA------NKDLFIDKQGNF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 791 GTRLHGgkDSAS-PRYIFTMLSSLARLLFPPKDDHTLKFLYdDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDV 869
Cdd:PRK09631 93 GNLFTG--DPASaARYIECRLTPLAKEVLYNKEITEYEPSY-DGRNNEPLCLPAKIPVILIQGAEGIAVGMATKILPHNF 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 870 REIVNNIRRLMDGeEPLPMLPSYKNfkGTIEELapNQY-------VISGEVAILNSTTIEISELPVRTWTQTYKEQVLEP 942
Cdd:PRK09631 170 NEILQAVKSELLG-ESFALYPDFPT--GGIVDV--SEYadgngkvLVRAKIETKDEKTIVIREIPFGTTTESLIASIEKA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 943 MLNGTEKTPPlITDYreyhTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHvgcLKKYDTVLDILRdF 1022
Cdd:PRK09631 245 ARKGKIKISS-INDY----TAENVEIEIKLPRGVYASEVIEALYAYTDCEVSISVNLLVIKDR---YPVIYTVTDIIK-F 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 19913406 1023 FELRLKYYgLRKEwllgmLGAESAKLnnqarfiLEKIDGK----IIIENKPKKEL 1073
Cdd:PRK09631 316 HAEHLQKV-LKME-----LELERAKL-------LEKIFAKtleqIFIEERIYKRI 357
|
|
| TOPRIM_TopoIIA_GyrB |
cd03366 |
TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain ... |
455-565 |
6.08e-24 |
|
TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. DNA gyrase is more effective at relaxing supercoils than decatentating DNA. DNA gyrase in addition inserts negative supercoils in the presence of ATP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173786 [Multi-domain] Cd Length: 114 Bit Score: 98.11 E-value: 6.08e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 455 CTLILTEGDSAktlavSGLGVVGRDKY--GVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEdedsLKTLR 532
Cdd:cd03366 1 SELYIVEGDSA-----GGSAKQGRDRRfqAILPLRGKILNVEKARLDKILKNEEIRALITALGTGIGEDFD----LEKLR 71
|
90 100 110
....*....|....*....|....*....|...
gi 19913406 533 YGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLL 565
Cdd:cd03366 72 YHKIIIMTDADVDGAHIRTLLLTFFFRYMRPLI 104
|
|
| PTZ00109 |
PTZ00109 |
DNA gyrase subunit b; Provisional |
266-655 |
5.20e-19 |
|
DNA gyrase subunit b; Provisional
Pssm-ID: 240272 [Multi-domain] Cd Length: 903 Bit Score: 93.79 E-value: 5.20e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 266 GFRSYVDMYLKDKL----DETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSkGGRHVDYVADQIvTKLVDVV 341
Cdd:PTZ00109 376 GTREFLEELIKDKTplykDINIISIRGVIKNVNVEVSLSWSLESYTALIKSFANNVSTT-AGTHIDGFKYAI-TRCVNGN 453
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 342 KKKN---KGG-VAVKAHQVKNHMWIFVNALIENPTFDSQTKEnmtlqpksfgstcQLSEKFIKAaigcgIVESILNWvKF 417
Cdd:PTZ00109 454 IKKNgyfKGNfVNIPGEFIREGMTAIISVKLNGAEFDGQTKT-------------KLGNHLLKT-----ILESIVFE-QL 514
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 418 KAQVQLNKKCSAVKHNRIKGIPKLDDANDAG-----GRNS-----------TECT--------LILTEGDSAktlAVSGL 473
Cdd:PTZ00109 515 SEILEFEPNLLLAIYNKSLAAKKAFEEAKAAkdlirQKNNqyystilpgklVDCIsddierneLFIVEGESA---AGNAK 591
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 474 GVVGRDKYGVFPLRGKILNVRE-ASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLK----------------------- 529
Cdd:PTZ00109 592 QARNREFQAVLPLKGKILNIEKiKNNKKVFENSEIKLLITSIGLSVNPVTWRQYDLShgtkaskdesvqnnnstltkkkn 671
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 530 -----TLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQemafyslpefEEWKSSTPN 604
Cdd:PTZ00109 672 slfdtPLRYGKIILLTDADVDGEHLRILLLTLLYRFCPSLYEHGRVYVACPPLYRITNNRM----------KQFNVSTKN 741
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 19913406 605 HKKWKVKYYKGLGTSTSKE-AKEYFADMKRHRIQFKYSGPEDDAAISLAFSK 655
Cdd:PTZ00109 742 SKKYIYTWSDEELNVLIKLlNKDYSSKETTRSVEEKGNAPDLDNEYEDEKLD 793
|
|
| gyrA |
TIGR01063 |
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ... |
713-1089 |
9.81e-19 |
|
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273423 [Multi-domain] Cd Length: 800 Bit Score: 92.76 E-value: 9.81e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 713 RSIPSMVDGLKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSSYH-HGEMSLMMTIINLAQNFvgSNNLNLLQPIG 788
Cdd:TIGR01063 25 RALPDVRDGLKPVHRRILYAMYElglTPDKPYKKSARIVGDV--MGKYHpHGDSAIYDTLVRMAQDF--SLRYPLVDGQG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 789 QFGTRlhGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFL--YDDNQRvEPEWYIPIIPMVLINGAEGIGTGWSCKIPN 866
Cdd:TIGR01063 101 NFGSI--DGDPPAAMRYTEARLTKIAEELLRDIDKETVDFVpnYDGSEQ-EPTVLPSRFPNLLVNGSSGIAVGMATNIPP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 867 FDVREIVNNIRRLMDGEE----------PLPMLP-------------SYKNFKGTIeelapnqyVISGEVAILNS----T 919
Cdd:TIGR01063 178 HNLGEIIDALLAYIDNPDisiqelleviKGPDFPtggiilgrsgirsAYETGRGSI--------VIRARAEIEEDskgrE 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 920 TIEISELPVRTWTQTYKEQVLEpMLNgtEKTPPLITDYREYHTDTTVKFVVkmtEEKLAEAERVGLHKVFK---LQTSLT 996
Cdd:TIGR01063 250 AIIVTEIPYQVNKARLIEKIAE-LVR--EKKIEGISDIRDESDREGIRIVI---ELKRDAVAEVVLNNLYKqtqLQVSFG 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 997 CNSMVLFDHvgcLKKYDTVLDILRDFFELRLK------YYGLRK-----EWLLGMLGAesakLNNqarfilekIDGKI-I 1064
Cdd:TIGR01063 324 INMLALVKG---LPKVLNLKELLEAFVEHRKDvitrrtIFELRKaeeraHILEGLLIA----LDN--------IDEVIaL 388
|
410 420
....*....|....*....|....*
gi 19913406 1065 IENKPKKELIKVLIQRGYDSDPVKA 1089
Cdd:TIGR01063 389 IRASQNTEEAKTRLVERFSLSEIQA 413
|
|
| gyrB |
PRK14939 |
DNA gyrase subunit B; Provisional |
105-586 |
1.31e-18 |
|
DNA gyrase subunit B; Provisional
Pssm-ID: 237860 [Multi-domain] Cd Length: 756 Bit Score: 92.08 E-value: 1.31e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 105 IRVTIDPENNlISIWNNGKGIPVVEHKVEKmyVPAL--IFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVeTA 182
Cdd:PRK14939 61 ITVTIHADGS-VSVSDNGRGIPTDIHPEEG--VSAAevIMTVLHAGGKFDQNSYKVSGGLHGVGVSVVNALSEWLEL-TI 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 183 SREyKKMFKQTWmdNMGRA-------GEMELKpfnGedyTCITFQPDLSKFKMQSLDKDIVAlmvRRAYDIAgstkdvkv 255
Cdd:PRK14939 137 RRD-GKIHEQEF--EHGVPvaplkvvGETDKT---G---TEVRFWPSPEIFENTEFDYDILA---KRLRELA-------- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 256 FLNgnklpvkgfrSYVDMYLKDKLDETGNSL-----------------KVIHEQVNH--------RWEVCL----TMSEK 306
Cdd:PRK14939 197 FLN----------SGVRIRLKDERDGKEEEFhyeggikafveylnrnkTPLHPNIFYfsgekdgiGVEVALqwndSYQEN 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 307 GFqqiSFVNSIATSKGGRHV------------DYVADQIVTKlvdvvKKKNK--------GGVAVKAhqVKnhmwifvna 366
Cdd:PRK14939 267 VL---CFTNNIPQRDGGTHLagfraaltrtinNYIEKEGLAK-----KAKVSltgddareGLTAVLS--VK--------- 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 367 lIENPTFDSQTKENMtlqpksfGStcqlSEkfIKaaigcGIVESILN--WVKF------KAQVQLNKKCSAVKH------ 432
Cdd:PRK14939 328 -VPDPKFSSQTKDKL-------VS----SE--VR-----PAVESLVNekLSEFleenpnEAKIIVGKIIDAARAreaark 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 433 ----NRIKGIpkLDDAN------DAGGRNSTECTLILTEGDSA----KTlavsglgvvGRD-KY-GVFPLRGKILNVREA 496
Cdd:PRK14939 389 arelTRRKGA--LDIAGlpgklaDCQEKDPALSELYLVEGDSAggsaKQ---------GRDrKFqAILPLKGKILNVEKA 457
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 497 SHKQIMENAEINNIIKIVGLQYKKnyeDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIhhnwpsllrHRFLEEFIT- 575
Cdd:PRK14939 458 RFDKMLSSQEIGTLITALGCGIGR---DEFNPDKLRYHKIIIMTDADVDGSHIRTLLLTFF---------YRQMPELIEr 525
|
570
....*....|....*....
gi 19913406 576 --------PIVKVSKNKQE 586
Cdd:PRK14939 526 ghlyiaqpPLYKVKKGKQE 544
|
|
| PRK09630 |
PRK09630 |
DNA topoisomerase IV subunit A; Provisional |
712-934 |
2.07e-17 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 170022 Cd Length: 479 Bit Score: 87.26 E-value: 2.07e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 712 ERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVaeMSSYHHGEMSLMMTIINLAqnfvgsNNLNLLQPIGQFG 791
Cdd:PRK09630 22 ERAIPHILDGLKPVQRRLLWTLFRMDDGKMHKVANIAGRT--MALHPHGDAPIVEALVVLA------NKGYLIDTQGNFG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 792 TRLHGGKDSASpRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRvEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVRE 871
Cdd:PRK09630 94 NPLTGDPHAAA-RYIEARLSPLAKEVLFNTDLMTFHDSYDGREK-EPDILPAKLPLLLLHGVDGIAVGMTTKIFPHNFCE 171
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19913406 872 IVN-NIRRLMDgeEPLPMLPSYKNfKGTIEelaPNQY-------VISGEVAILNSTTIEISELPVRTWTQT 934
Cdd:PRK09630 172 LLEaQIAILND--QPFTLLPDFPS-GGTMD---ASEYqdglgsiTLRASIDIINDKTLLIKEICPSTTTET 236
|
|
| PRK12758 |
PRK12758 |
DNA gyrase/topoisomerase IV subunit A; |
712-867 |
1.81e-12 |
|
DNA gyrase/topoisomerase IV subunit A;
Pssm-ID: 237192 [Multi-domain] Cd Length: 869 Bit Score: 72.34 E-value: 1.81e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 712 ERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEmssYH-HGEMSLMMTIINLAQnfvgsNNLnLLQPIGQF 790
Cdd:PRK12758 41 ERAVPHIEDGLKPVQRRILHSMKEMDDGRYNKVANVVGHTMQ---YHpHGDASIGDALVQLGQ-----KDL-LIDTQGNW 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 791 GTRLhGGKDSASPRYIFTMLSSLA-RLLFPPKDDHtLKFLYDDNQRvEPEwYIPI-IPMVLINGAEGIGTGWSCKI-P-N 866
Cdd:PRK12758 112 GNIL-TGDGAAAPRYIEARLSKFAlEVVFNPKTTE-WQLSYDGRKK-EPV-TLPVkFPLLLAQGAEGIAVGLSTKIlPhN 187
|
.
gi 19913406 867 F 867
Cdd:PRK12758 188 F 188
|
|
| TopoII_MutL_Trans |
cd00329 |
MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the ... |
267-379 |
2.90e-11 |
|
MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes. The GyrB dimerizes in response to ATP binding, and is homologous to the N-terminal half of eukaryotic Topo II and the ATPase fragment of MutL. Type II DNA topoisomerases catalyze the ATP-dependent transport of one DNA duplex through another, in the process generating transient double strand breaks via covalent attachments to both DNA strands at the 5' positions. Included in this group are proteins similar to human MLH1 and PMS2. MLH1 forms a heterodimer with PMS2 which functions in meiosis and in DNA mismatch repair (MMR). Cells lacking either hMLH1 or hPMS2 have a strong mutator phenotype and display microsatellite instability (MSI). Mutation in hMLH1 accounts for a large fraction of Lynch syndrome (HNPCC) families.
Pssm-ID: 238202 [Multi-domain] Cd Length: 107 Bit Score: 61.51 E-value: 2.90e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 267 FRSYVDMYLKDKLDEtgnslKVIHEQVNH---RWEVCLTMSE----KGFQQISFVNSIATSKGGRHVDYVADQIVTKLvd 339
Cdd:cd00329 1 LKDRLAEILGDKVAD-----KLIYVEGESdgfRVEGAISYPDsgrsSKDRQFSFVNGRPVREGGTHVKAVREAYTRAL-- 73
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 19913406 340 vvkkknkggvavKAHQVKNHMWIFVNALIEN--PTFD-SQTKE 379
Cdd:cd00329 74 ------------NGDDVRRYPVAVLSLKIPPslVDVNvHPTKE 104
|
|
| HATPase_GyrB-like |
cd16928 |
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes ... |
81-258 |
1.70e-10 |
|
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes histidine kinase-like ATPase domain of the B subunit of DNA gyrase. Bacterial DNA gyrase is a type II topoisomerase (type II as it transiently cleaves both strands of DNA) which catalyzes the introduction of negative supercoils into DNA, possibly by a mechanism in which one segment of the double-stranded DNA substrate is passed through a transient break in a second segment. It consists of GyrA and GyrB subunits in an A2B2 stoichiometry; GyrA subunits catalyze strand-breakage and reunion reactions, and GyrB subunits hydrolyze ATP. DNA gyrase is found in bacteria, plants and archaea, but as it is absent in humans it is a possible drug target for the treatment of bacterial and parasite infections.
Pssm-ID: 340405 [Multi-domain] Cd Length: 180 Bit Score: 61.78 E-value: 1.70e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 81 LYKIFDEILVNAAD-------NKqrdpkmscIRVTIDpENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDD 153
Cdd:cd16928 1 LHHLVWEIVDNSIDealagyaTE--------IEVTLH-EDNSITVEDNGRGIPVDIHPKTGKSAVEVVLTVLHAGGKFDG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 154 DEKKVTGGRNGYGAKLCNIFSTKFTVETAsREyKKMFKQTWMDNmGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDK 233
Cdd:cd16928 72 GSYKVSGGLHGVGVSVVNALSERLEVEVK-RD-GKIYRQEFSRG-GPLTPLEVIGETKKTGTTVRFWPDPEIFEKTEFDF 148
|
170 180
....*....|....*....|....*
gi 19913406 234 DIVAlmvRRAYDIAGSTKDVKVFLN 258
Cdd:cd16928 149 DTLK---RRLRELAFLNKGLKIVLE 170
|
|
| PRK05561 |
PRK05561 |
DNA topoisomerase 4 subunit A; |
712-958 |
2.46e-10 |
|
DNA topoisomerase 4 subunit A;
Pssm-ID: 235503 [Multi-domain] Cd Length: 742 Bit Score: 65.13 E-value: 2.46e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 712 ERSIPSMVDGLKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSSYH-HGEMSLMMTIINLAQNFvgSNNLNLLQPI 787
Cdd:PRK05561 33 DRALPDVRDGLKPVQRRILYAMSElglTPDAKFKKSARVVGDV--LGKYHpHGDSSIYDAMVRMAQDF--SYRYPLVDGQ 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 788 GQFGTRlhGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFL--YDDNQRvEPEWYIPIIPMVLINGAEGIGTGWSCKIP 865
Cdd:PRK05561 109 GNFGSI--DGDPAAAMRYTEARLSPIAELLLEEIDEGTVDFVpnFDGTLK-EPTVLPARFPNLLLNGATGIAVGMATDIP 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 866 NFDVREIVNNIRRLMDGEE----------PLPMLPS--------------YKNFKG--------TIEELAPNQYVisgev 913
Cdd:PRK05561 186 PHNLREVIDAAIHLIDNPDatleelmefvPGPDFPTggeiitgrdgirkaYETGRGsirvrarwEIEDLAGGRWQ----- 260
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 19913406 914 ailnsttIEISELPVrtwtQTYKEQVLEPMLNGT-EKTPPLITDYR 958
Cdd:PRK05561 261 -------IVITELPY----QVSKAKLIEQIAELMnAKKLPGIADVR 295
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
80-187 |
3.17e-08 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 53.14 E-value: 3.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 80 GLYKIFDEILVNAADNKqrdPKMSCIRVTIDPENNL-ISIWNNGKGIPVVEHKvekmyvpaLIFGQLLTSSnydddekKV 158
Cdd:pfam02518 5 RLRQVLSNLLDNALKHA---AKAGEITVTLSEGGELtLTVEDNGIGIPPEDLP--------RIFEPFSTAD-------KR 66
|
90 100 110
....*....|....*....|....*....|.
gi 19913406 159 TGGRNGYGAKLCNIFSTKF--TVETASREYK 187
Cdd:pfam02518 67 GGGGTGLGLSIVRKLVELLggTITVESEPGG 97
|
|
| PRK13979 |
PRK13979 |
DNA topoisomerase IV subunit A; Provisional |
712-884 |
4.96e-08 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 237576 [Multi-domain] Cd Length: 957 Bit Score: 57.81 E-value: 4.96e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 712 ERSIPSMVDGLKPGQRKVLFTCFKRN---DKREVKVAQLAGSVaeMSSYH-HGEMSLMMTIINLAQNFvgSNNLNLLQPI 787
Cdd:PRK13979 36 DRALPDVRDGLKPVHRRILYGAYMLKafpDKPYYKSARIVGDI--LGKYHpHGDSSVYDAMVILAQDF--TTRMPLIDGH 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 788 GQFGTRlhGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFL--YDDNQRvEPEWYIPIIPMVLINGAEGIGTGWSCKIP 865
Cdd:PRK13979 112 GNWGSI--DGDSAAAMRYTEARLTPIAMEMLRDIDKDVVNMVdnYSDSEK-EPEVLPARYPNLLVNGAFGIAVGLATNIP 188
|
170
....*....|....*....
gi 19913406 866 NFDVREIVNNIRRLMDGEE 884
Cdd:PRK13979 189 PHNLKEVIDGTLAYIDNNE 207
|
|
| GyrA |
COG0188 |
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair]; |
713-881 |
1.82e-07 |
|
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
Pssm-ID: 439958 [Multi-domain] Cd Length: 804 Bit Score: 55.82 E-value: 1.82e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 713 RSIPSMVDGLKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSSYH-HGEMSLMMTIINLAQNFvgSNNLNLLQPIG 788
Cdd:COG0188 34 RALPDVRDGLKPVHRRILYAMHElglTPDKPYKKSARVVGDV--MGKYHpHGDSAVYDALVRMAQDF--SMRYPLVDGQG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 789 QFGTRlhGGkDS-ASPRYIFTMLSSLARLLFPPKDDHTLKFL--YDDNQRvEPEwYIP-IIPMVLINGAEGIGTGWSCKI 864
Cdd:COG0188 110 NFGSI--DG-DPaAAMRYTEARLAKIAEELLADIDKDTVDFVpnYDGSEQ-EPT-VLPaRFPNLLVNGSSGIAVGMATNI 184
|
170
....*....|....*....
gi 19913406 865 P--NfdVREIVNNIRRLMD 881
Cdd:COG0188 185 PphN--LGEVIDACIALID 201
|
|
| PRK05560 |
PRK05560 |
DNA gyrase subunit A; Validated |
713-902 |
2.62e-07 |
|
DNA gyrase subunit A; Validated
Pssm-ID: 235502 [Multi-domain] Cd Length: 805 Bit Score: 55.42 E-value: 2.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 713 RSIPSMVDGLKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSSYH-HGEMSLMMTIINLAQNFvgSNNLNLLQPIG 788
Cdd:PRK05560 29 RALPDVRDGLKPVHRRILYAMNElgnTPDKPYKKSARIVGDV--MGKYHpHGDSAVYDALVRMAQDF--SMRYPLVDGQG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 789 QFGTRlhGGkDS-ASPRYIFTMLSSLARLLFPPKDDHTLKFL--YDDNQRvEPEwYIPI-IPMVLINGAEGIGTGWSCKI 864
Cdd:PRK05560 105 NFGSI--DG-DPaAAMRYTEARMSKIAHELLADIDKETVDFVpnYDGSEQ-EPT-VLPArFPNLLVNGSSGIAVGMATNI 179
|
170 180 190
....*....|....*....|....*....|....*...
gi 19913406 865 PNFDVREIVNNIRRLMDGEEplpmlpsyknfkGTIEEL 902
Cdd:PRK05560 180 PPHNLGEVIDACLALIDNPD------------ITIEEL 205
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
80-180 |
1.45e-06 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 48.41 E-value: 1.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 80 GLYKIFDEILVNAADNKqrdPKMSCIRVTIDPENN--LISIWNNGKGIPvvEHKVEKMYVPaliFGQLltssnyddDEKK 157
Cdd:smart00387 5 RLRQVLSNLLDNAIKYT---PEGGRITVTLERDGDhvEITVEDNGPGIP--PEDLEKIFEP---FFRT--------DKRS 68
|
90 100
....*....|....*....|...
gi 19913406 158 VTGGRNGYGAKLCNIFSTKFTVE 180
Cdd:smart00387 69 RKIGGTGLGLSIVKKLVELHGGE 91
|
|
| Toprim |
pfam01751 |
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim ... |
456-556 |
1.59e-06 |
|
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.
Pssm-ID: 396354 [Multi-domain] Cd Length: 93 Bit Score: 47.74 E-value: 1.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 456 TLILTEGDS-AKTLAvsglGVVGRDKYGVFPLRGKILNVREASHKQIMenaeinNIIKIVGLQYKKnyededslktlryg 534
Cdd:pfam01751 1 ELIIVEGPSdAIALE----KALGGGFQAVVAVLGHLLSLEKGPKKKAL------KALKELALKAKE-------------- 56
|
90 100
....*....|....*....|..
gi 19913406 535 kIMIMTDQDQDGSHIKGLLINF 556
Cdd:pfam01751 57 -VILATDPDREGEAIALKLLEL 77
|
|
| TOPRIM |
cd00188 |
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type ... |
455-566 |
5.36e-04 |
|
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from bacterial and archaea, and bacterial DNA repair proteins of the RecR/M family. This domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in nucleotide polymerization by primases and in strand joining in topoisomerases and, as a general acid in strand cleavage by topisomerases and nucleases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173773 [Multi-domain] Cd Length: 83 Bit Score: 40.10 E-value: 5.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913406 455 CTLILTEGDS-AKTLAVSGlgvvgRDKYGVFPLRGKILNvreashkqimenAEINNIIKIVGlqykknyededslktlRY 533
Cdd:cd00188 1 KKLIIVEGPSdALALAQAG-----GYGGAVVALGGHALN------------KTRELLKRLLG----------------EA 47
|
90 100 110
....*....|....*....|....*....|...
gi 19913406 534 GKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLR 566
Cdd:cd00188 48 KEVIIATDADREGEAIALRLLELLKSLGKKVRR 80
|
|
| |
