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Conserved domains on  [gi|114796646|ref|NP_001041660|]
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regulator of chromosome condensation isoform b [Homo sapiens]

Protein Classification

RCC1 domain-containing protein( domain architecture ID 11474102)

RCC1 (regulator of chromosome condensation) domain-containing protein similar to Arabidopsis UVR8 (UV RESISTANCE LOCUS 8), which plays an important role in mediating the effects of UV-B radiation on pathogen resistance by controlling the expression of the sinapate biosynthetic pathway.

Gene Ontology:  GO:0003682|GO:0005085
PubMed:  9510255|18442486

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 46-406 6.33e-54

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 183.25  E-value: 6.33e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114796646  46 SHS---TEPGLVLTLGQGDVGQLGLGENVMeRKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSV 122
Cdd:COG5184    8 SHScalKSDGTVWCWGDNSYGQLGDGTTTD-RSTPVRVPGLSNVVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTT 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114796646 123 EGSemVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSfrDNNGVIGLLEPMKKSmVPVQVQLDV-PVVKVASGNDHL 201
Cdd:COG5184   87 DRT--TPVKVPGLTGVVAVAAGYYHSCALKSDGTVWCWGD--NSSGQLGDGTTTNRL-TPVQVDAGLsGVVAIAAGGYHT 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114796646 202 VMLTADGDLYTLGCGEQGQLG-------RVPELFANRGGrqglerllvpkcvmlksrgsrghvrFQDAFCGAYFTFAISH 274
Cdd:COG5184  162 CALKSDGTVWCWGANSYGQLGdgtttdrPTPVQVGGLSG-------------------------VVAVAAGGDHSCALKS 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114796646 275 EGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNstksWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGeGAEEKSI 354
Cdd:COG5184  217 DGTVWCWGSNSSGQLGDGTTTDRATPVQVAGLTG----VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDG-TTTDRST 291

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 114796646 355 PTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV 406
Cdd:COG5184  292 PVKVPGLSGVVAVAAGSSHTCALLTDGTVWCWGDNAYGQLGDGTTTDRSTPV 343
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 46-406 6.33e-54

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 183.25  E-value: 6.33e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114796646  46 SHS---TEPGLVLTLGQGDVGQLGLGENVMeRKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSV 122
Cdd:COG5184    8 SHScalKSDGTVWCWGDNSYGQLGDGTTTD-RSTPVRVPGLSNVVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTT 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114796646 123 EGSemVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSfrDNNGVIGLLEPMKKSmVPVQVQLDV-PVVKVASGNDHL 201
Cdd:COG5184   87 DRT--TPVKVPGLTGVVAVAAGYYHSCALKSDGTVWCWGD--NSSGQLGDGTTTNRL-TPVQVDAGLsGVVAIAAGGYHT 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114796646 202 VMLTADGDLYTLGCGEQGQLG-------RVPELFANRGGrqglerllvpkcvmlksrgsrghvrFQDAFCGAYFTFAISH 274
Cdd:COG5184  162 CALKSDGTVWCWGANSYGQLGdgtttdrPTPVQVGGLSG-------------------------VVAVAAGGDHSCALKS 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114796646 275 EGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNstksWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGeGAEEKSI 354
Cdd:COG5184  217 DGTVWCWGSNSSGQLGDGTTTDRATPVQVAGLTG----VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDG-TTTDRST 291

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 114796646 355 PTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV 406
Cdd:COG5184  292 PVKVPGLSGVVAVAAGSSHTCALLTDGTVWCWGDNAYGQLGDGTTTDRSTPV 343
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
380-431 3.62e-12

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 60.61  E-value: 3.62e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 114796646  380 DGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGkqLENRVVLSVSSGGQHTVLL 431
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEG--LSGNKVVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 46-406 6.33e-54

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 183.25  E-value: 6.33e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114796646  46 SHS---TEPGLVLTLGQGDVGQLGLGENVMeRKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSV 122
Cdd:COG5184    8 SHScalKSDGTVWCWGDNSYGQLGDGTTTD-RSTPVRVPGLSNVVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTT 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114796646 123 EGSemVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSfrDNNGVIGLLEPMKKSmVPVQVQLDV-PVVKVASGNDHL 201
Cdd:COG5184   87 DRT--TPVKVPGLTGVVAVAAGYYHSCALKSDGTVWCWGD--NSSGQLGDGTTTNRL-TPVQVDAGLsGVVAIAAGGYHT 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114796646 202 VMLTADGDLYTLGCGEQGQLG-------RVPELFANRGGrqglerllvpkcvmlksrgsrghvrFQDAFCGAYFTFAISH 274
Cdd:COG5184  162 CALKSDGTVWCWGANSYGQLGdgtttdrPTPVQVGGLSG-------------------------VVAVAAGGDHSCALKS 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114796646 275 EGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNstksWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGeGAEEKSI 354
Cdd:COG5184  217 DGTVWCWGSNSSGQLGDGTTTDRATPVQVAGLTG----VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDG-TTTDRST 291

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 114796646 355 PTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV 406
Cdd:COG5184  292 PVKVPGLSGVVAVAAGSSHTCALLTDGTVWCWGDNAYGQLGDGTTTDRSTPV 343
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 87-434 6.08e-52

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 177.86  E-value: 6.08e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114796646  87 VQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSemVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSfrDN 166
Cdd:COG5184    1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRS--TPVRVPGLSNVVAVAAGGDHTCALKADGTVWCWGN--NS 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114796646 167 NGVIGLLEPmKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRvpelfANRGGRqglerlLVPKCV 246
Cdd:COG5184   77 YGQLGDGTT-TDRTTPVKVPGLTGVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGD-----GTTTNR------LTPVQV 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114796646 247 MLksrgsrGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNstksWVGFSGGQHHTVCM 326
Cdd:COG5184  145 DA------GLSGVVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLSG----VVAVAAGGDHSCAL 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114796646 327 DSEGKAYSLGRAEYGRLGLGeGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPV 406
Cdd:COG5184  215 KSDGTVWCWGSNSSGQLGDG-TTTDRATPVQVAGLTGVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPV 293

                        330       340
                 ....*....|....*....|....*...
gi 114796646 407 EMMGkqLENrvVLSVSSGGQHTVLLVKD 434
Cdd:COG5184  294 KVPG--LSG--VVAVAAGSSHTCALLTD 317
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
380-431 3.62e-12

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 60.61  E-value: 3.62e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 114796646  380 DGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGkqLENRVVLSVSSGGQHTVLL 431
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEG--LSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
102-151 8.19e-11

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 56.76  E-value: 8.19e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 114796646  102 SGQVYSFGCNDEGALGRDTSVegSEMVPGKVEL--QEKVVQVSAGDSHTAAL 151
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTE--NVLVPQKVEGlsGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
275-326 2.03e-09

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 52.90  E-value: 2.03e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 114796646  275 EGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNstKSWVGFSGGQHHTVCM 326
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSG--NKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
52-99 2.30e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 47.13  E-value: 2.30e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 114796646   52 GLVLTLGQGDVGQLGLGENVmERKKPALVSIPED--VVQAEAGGMHTVCL 99
Cdd:pfam00415   2 GRVYTWGRNDYGQLGLGTTE-NVLVPQKVEGLSGnkVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
138-162 1.02e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 44.72  E-value: 1.02e-06
                          10        20
                  ....*....|....*....|....*
gi 114796646  138 VVQVSAGDSHTAALTDDGRVFLWGS 162
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGD 25
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
207-272 1.45e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 44.82  E-value: 1.45e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 114796646  207 DGDLYTLGCGEQGQLGRVPElfanrggrqglERLLVPKCVMlksrgSRGHVRFQDAFCGAYFTFAI 272
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTT-----------ENVLVPQKVE-----GLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
154-204 3.47e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 40.96  E-value: 3.47e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 114796646  154 DGRVFLWGsfRDNNGVIGlLEPMKKSMVPVQVQL--DVPVVKVASGNDHLVML 204
Cdd:pfam00415   1 DGRVYTWG--RNDYGQLG-LGTTENVLVPQKVEGlsGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
329-372 5.72e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 40.58  E-value: 5.72e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 114796646  329 EGKAYSLGRAEYGRLGLGEGaEEKSIPTLISRLPA--VSSVACGAS 372
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTT-ENVLVPQKVEGLSGnkVVQVACGGD 45
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
364-393 3.10e-04

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 37.79  E-value: 3.10e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 114796646  364 VSSVACGASVGYAVTKDGRVFAWGMGTNYQ 393
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
86-114 8.71e-04

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 36.63  E-value: 8.71e-04
                          10        20
                  ....*....|....*....|....*....
gi 114796646   86 VVQAEAGGMHTVCLSKSGQVYSFGCNDEG 114
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYG 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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