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Conserved domains on  [gi|116008086|ref|NP_001036751|]
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crumbs, isoform B [Drosophila melanogaster]

Protein Classification

neurexin-3; calcium-binding EGF-like domain-containing protein( domain architecture ID 11363242)

neurexin-3 is a neuronal cell surface protein that may be involved in cell recognition and cell adhesion, and may also mediate intracellular signaling; calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_G_1 pfam00054
Laminin G domain;
1091-1226 1.30e-36

Laminin G domain;


:

Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 135.52  E-value: 1.30e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116008086  1091 FRTTLPNGVLAFGttGEKNEPVSYILELINGRLNLHSSLLNKWEGVFIGSKLNDSNWHKVFVAINTSHLVLSANDEQaiF 1170
Cdd:pfam00054    1 FRTTEPSGLLLYN--GTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEA--R 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 116008086  1171 PVGSYETANNSQPSFPRTYLGGTIPNLKSYLRHLTHQPSaFVGCMQDIMVNGKWIF 1226
Cdd:pfam00054   77 PTGESPLGATTDLDVDGPLYVGGLPSLGVKKRRLAISPS-FDGCIRDVIVNGKPLD 131
Laminin_G_1 pfam00054
Laminin G domain;
1324-1486 2.70e-25

Laminin G domain;


:

Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 103.17  E-value: 2.70e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116008086  1324 IRTREPTGQVFYLGTDPRKAptknigdsYVAAKLHGGELLVKMQFSGTPeAYTVGGQKLDNGYNHLIEVVRNQTLVQVKL 1403
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERD--------FLALELRDGRLEVSYDLGSGA-AVVRSGDKLNDGKWHSVELERNGRSGTLSV 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116008086  1404 NGTEyfrktlsttglldaqvlylggpAPTRESLLGATTepgIIPVPGA----GIPIEdtTVPKEADDSRDYFKGIIQDVK 1479
Cdd:pfam00054   72 DGEA----------------------RPTGESPLGATT---DLDVDGPlyvgGLPSL--GVKKRRLAISPSFDGCIRDVI 124


                   ....*..
gi 116008086  1480 VSNGSLN 1486
Cdd:pfam00054  125 VNGKPLD 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1628-1764 1.91e-09

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 57.43  E-value: 1.91e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116008086  1628 FRTRAG-GTLLYIDNVDG-FFEIGVNGGRVTITWKLSALHFGESARfEKENTDGEWSRIYLRAHNSKLeggwkgwESMVD 1705
Cdd:pfam02210    1 FRTRQPnGLLLYAGGGGSdFLALELVNGRLVLRYDLGSGPESLLSS-GKNLNDGQWHSVRVERNGNTL-------TLSVD 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 116008086  1706 PTPAFSTDIDQaaFQSLIATSTQVYLGGMPESRqaRGSTLSAQQGsqFKGCVGEARVGD 1764
Cdd:pfam02210   73 GQTVVSSLPPG--ESLLLNLNGPLYLGGLPPLL--LLPALPVRAG--FVGCIRDVRVNG 125
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 728-764 1.19e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.64  E-value: 1.19e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 116008086  728 DVDECLSF-PCLNGATCHNKINAYECVCQPGYEGENCE 764
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 945-981 1.03e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 1.03e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 116008086  945 NINECDS-NPCSKHGNCNDGIGTYTCECEPGFEGTHCE 981
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 91-228 1.11e-07

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 53.19  E-value: 1.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116008086   91 AYFNGSTYLRLTTPMPIWDHSAISF----RSCRGgeIL---AQQYNKNSIVISVLNDFLQISlagpaVHGPNNRLDVKLP 163
Cdd:cd00110     2 VSFSGSSYVRLPTLPAPRTRLSISFsfrtTSPNG--LLlyaGSQNGGDFLALELEDGRLVLR-----YDLGSGSLVLSSK 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 116008086  164 YQLLDNRWHTLQFKYEYGNLYLHVDRAASI-FANSTYNSQFLTNQDI-------GYKDAILILGNSFSGCLLD 228
Cdd:cd00110    75 TPLNDGQWHSVSVERNGRSVTLSVDGERVVeSGSPGGSALLNLDGPLylgglpeDLKSPGLPVSPGFVGCIRD 147
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1837-1873 2.85e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 2.85e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 116008086 1837 DIDECLNTE-CLNNGTCINQVAAFFCQCQPGFEGQHCE 1873
Cdd:cd00054     1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1993-2030 2.96e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 2.96e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 116008086 1993 DINECES-NPCQNGGQCKDLVGRYECDCQgTGFEGIRCE 2030
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 766-801 1.15e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 1.15e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 116008086  766 DIDECGS-NPCSNGSTCIDRINNFTCNCIPGMTGRIC 801
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 843-879 2.06e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 2.06e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 116008086  843 NIDECLS-NPCTNGAKCLDRVKDYFCDCHNGYKGKNCE 879
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1875-1910 2.54e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.54e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 116008086 1875 NIDECADQ-PCHNGGNCTDLIASYVCDCPEDYMGPQC 1910
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 804-841 3.06e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 3.06e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 116008086  804 DIDDCV-GDPCLNGGQCIDQLGGFRCDCSgTGYEGENCE 841
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 425-460 3.15e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 3.15e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 116008086  425 NVDECD-KNPCLNGGRCFDTYGWYTCQCLDGWGGEIC 460
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1529-1558 5.40e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 5.40e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 116008086 1529 NPCLHNAECRNTWNDYTCKCPNGYKGKNCQ 1558
Cdd:cd00054     9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 386-423 5.56e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 5.56e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 116008086  386 DTDECASQ-PCQNNGSCIDRINGFSCDCSgTGYTGAFCQ 423
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 689-725 4.41e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 4.41e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 116008086  689 DVDECTLHPKICGNGICKNEKGSYKCYCTPGFTGVHC 725
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 983-1018 1.48e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 1.48e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 116008086  983 NIDECDRYNPCQR-GTCYDQIDDYDCDCDANYGGKNC 1018
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 652-686 1.81e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 1.81e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 116008086  652 NQCATQ-PCQNGGECVDLPNGdYECKCTRGWTGRTC 686
Cdd:cd00054     3 DECASGnPCQNGGTCVNTVGS-YRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 466-495 6.99e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 6.99e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 116008086   466 CQTQQCLNGGTCLDKPIGFQCLCPPEYTGE 495
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2032-2069 7.77e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 7.77e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 116008086 2032 DIDECNmEGDYCGGLGRCFNKPGSFQCICQKPYCGAYC 2069
Cdd:cd00054     1 DIDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1252-1282 1.40e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 1.40e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 116008086  1252 CKPNPCHSNGECTDLWHTFACHCPRPFFGHT 1282
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2073-2111 4.14e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 4.14e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 116008086 2073 DPCNATDLCSNGGRCVESCGakpDYYCECPEGFAGKNCT 2111
Cdd:cd00054     3 DECASGNPCQNGGTCVNTVG---SYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 269-299 4.44e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 4.44e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 116008086   269 CLNDPCMGHGTCSSSPEGYECRCTARYSGKN 299
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 311-341 5.51e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 5.51e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 116008086  311 NPCENGGSClENSRGDYQCFCDPNHSGQHCE 341
Cdd:cd00054     9 NPCQNGGTC-VNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1959-1988 9.38e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 9.38e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 116008086  1959 CEITPCDNGGLCLTTGAVPMCKCSLGYTGR 1988
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
 
Name Accession Description Interval E-value
Laminin_G_1 pfam00054
Laminin G domain;
1091-1226 1.30e-36

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 135.52  E-value: 1.30e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116008086  1091 FRTTLPNGVLAFGttGEKNEPVSYILELINGRLNLHSSLLNKWEGVFIGSKLNDSNWHKVFVAINTSHLVLSANDEQaiF 1170
Cdd:pfam00054    1 FRTTEPSGLLLYN--GTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEA--R 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 116008086  1171 PVGSYETANNSQPSFPRTYLGGTIPNLKSYLRHLTHQPSaFVGCMQDIMVNGKWIF 1226
Cdd:pfam00054   77 PTGESPLGATTDLDVDGPLYVGGLPSLGVKKRRLAISPS-FDGCIRDVIVNGKPLD 131
Laminin_G_1 pfam00054
Laminin G domain;
1324-1486 2.70e-25

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 103.17  E-value: 2.70e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116008086  1324 IRTREPTGQVFYLGTDPRKAptknigdsYVAAKLHGGELLVKMQFSGTPeAYTVGGQKLDNGYNHLIEVVRNQTLVQVKL 1403
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERD--------FLALELRDGRLEVSYDLGSGA-AVVRSGDKLNDGKWHSVELERNGRSGTLSV 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116008086  1404 NGTEyfrktlsttglldaqvlylggpAPTRESLLGATTepgIIPVPGA----GIPIEdtTVPKEADDSRDYFKGIIQDVK 1479
Cdd:pfam00054   72 DGEA----------------------RPTGESPLGATT---DLDVDGPlyvgGLPSL--GVKKRRLAISPSFDGCIRDVI 124


                   ....*..
gi 116008086  1480 VSNGSLN 1486
Cdd:pfam00054  125 VNGKPLD 131
LamG smart00282
Laminin G domain;
1086-1223 4.83e-22

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 93.94  E-value: 4.83e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116008086   1086 DINLQFRTTLPNGVLAFGTTGEKNEPVSyiLELINGRLNLHSSLLNKWEGVFIGS-KLNDSNWHKVFVAINTSHLVLSAN 1164
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLA--LELRDGRLVLRYDLGSGPARLTSDPtPLNDGQWHRVAVERNGRSVTLSVD 78

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 116008086   1165 DE--QAIFPVGSYETANnsqpSFPRTYLGGTIPNLKSYLRHLTHqpsAFVGCMQDIMVNGK 1223
Cdd:smart00282   79 GGnrVSGESPGGLTILN----LDGPLYLGGLPEDLKLPPLPVTP---GFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1072-1221 7.81e-20

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 88.24  E-value: 7.81e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116008086 1072 TSLISVTTEREEG--YDINLQFRTTLPNGVLAFGTTGEKNEpvSYILELINGRLNLHSSLLnkWEGVFIGSK--LNDSNW 1147
Cdd:cd00110     7 SSYVRLPTLPAPRtrLSISFSFRTTSPNGLLLYAGSQNGGD--FLALELEDGRLVLRYDLG--SGSLVLSSKtpLNDGQW 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 116008086 1148 HKVFVAINTSHLVLSANDEQAI-FPVGSYETANNSQPSFprtYLGGTIPNLKSYLRHLTHqpsAFVGCMQDIMVN 1221
Cdd:cd00110    83 HSVSVERNGRSVTLSVDGERVVeSGSPGGSALLNLDGPL---YLGGLPEDLKSPGLPVSP---GFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
1319-1482 8.00e-15

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 73.14  E-value: 8.00e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116008086   1319 DISMFIRTREPTGQVFYLGTDPrkaptkniGDSYVAAKLHGGELLVKMQFSGTPEAYTVGGQKLDNGYNHLIEVVRNQTL 1398
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKG--------GGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRS 72

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116008086   1399 VQVKLNGTE--YFRKTLSTTGLLDAQVLYLGGPAPTRESLLGATTEPgiipvpgagipiedttvpkeaddsrdyFKGIIQ 1476
Cdd:smart00282   73 VTLSVDGGNrvSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTPG---------------------------FRGCIR 125


                    ....*.
gi 116008086   1477 DVKVSN 1482
Cdd:smart00282  126 NLKVNG 131
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1312-1480 1.15e-13

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 70.52  E-value: 1.15e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116008086 1312 RAIRSILDISMFIRTREPTGQVFYLGTDPrkaptkniGDSYVAAKLHGGEllVKMQFSGTPEAYTVG-GQKLDNGYNHLI 1390
Cdd:cd00110    16 PAPRTRLSISFSFRTTSPNGLLLYAGSQN--------GGDFLALELEDGR--LVLRYDLGSGSLVLSsKTPLNDGQWHSV 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116008086 1391 EVVRNQTLVQVKLNGTEYFRKTLSTTG--LLDAQVLYLGGPAPTRESLLGATtepgiipvpgagipiedttvpkeaddsR 1468
Cdd:cd00110    86 SVERNGRSVTLSVDGERVVESGSPGGSalLNLDGPLYLGGLPEDLKSPGLPV---------------------------S 138

                         170
                  ....*....|..
gi 116008086 1469 DYFKGIIQDVKV 1480
Cdd:cd00110   139 PGFVGCIRDLKV 150
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1628-1764 1.91e-09

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 57.43  E-value: 1.91e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116008086  1628 FRTRAG-GTLLYIDNVDG-FFEIGVNGGRVTITWKLSALHFGESARfEKENTDGEWSRIYLRAHNSKLeggwkgwESMVD 1705
Cdd:pfam02210    1 FRTRQPnGLLLYAGGGGSdFLALELVNGRLVLRYDLGSGPESLLSS-GKNLNDGQWHSVRVERNGNTL-------TLSVD 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 116008086  1706 PTPAFSTDIDQaaFQSLIATSTQVYLGGMPESRqaRGSTLSAQQGsqFKGCVGEARVGD 1764
Cdd:pfam02210   73 GQTVVSSLPPG--ESLLLNLNGPLYLGGLPPLL--LLPALPVRAG--FVGCIRDVRVNG 125
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 728-764 1.19e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.64  E-value: 1.19e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 116008086  728 DVDECLSF-PCLNGATCHNKINAYECVCQPGYEGENCE 764
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 945-981 1.03e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 1.03e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 116008086  945 NINECDS-NPCSKHGNCNDGIGTYTCECEPGFEGTHCE 981
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 91-228 1.11e-07

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 53.19  E-value: 1.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116008086   91 AYFNGSTYLRLTTPMPIWDHSAISF----RSCRGgeIL---AQQYNKNSIVISVLNDFLQISlagpaVHGPNNRLDVKLP 163
Cdd:cd00110     2 VSFSGSSYVRLPTLPAPRTRLSISFsfrtTSPNG--LLlyaGSQNGGDFLALELEDGRLVLR-----YDLGSGSLVLSSK 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 116008086  164 YQLLDNRWHTLQFKYEYGNLYLHVDRAASI-FANSTYNSQFLTNQDI-------GYKDAILILGNSFSGCLLD 228
Cdd:cd00110    75 TPLNDGQWHSVSVERNGRSVTLSVDGERVVeSGSPGGSALLNLDGPLylgglpeDLKSPGLPVSPGFVGCIRD 147
EGF_CA smart00179
Calcium-binding EGF-like domain;
728-764 1.56e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.17  E-value: 1.56e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 116008086    728 DVDECLSF-PCLNGATCHNKINAYECVCQPGYE-GENCE 764
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1837-1873 2.85e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 2.85e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 116008086 1837 DIDECLNTE-CLNNGTCINQVAAFFCQCQPGFEGQHCE 1873
Cdd:cd00054     1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1993-2030 2.96e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 2.96e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 116008086 1993 DINECES-NPCQNGGQCKDLVGRYECDCQgTGFEGIRCE 2030
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
LamG smart00282
Laminin G domain;
1624-1762 3.68e-07

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 51.19  E-value: 3.68e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116008086   1624 IDIAFRTRAG-GTLLYIDNVDG--FFEIGVNGGRVTITWKLSALHFGESARFEKENtDGEWSRIYLRAHNSKLeggwkgw 1700
Cdd:smart00282    2 ISFSFRTTSPnGLLLYAGSKGGgdYLALELRDGRLVLRYDLGSGPARLTSDPTPLN-DGQWHRVAVERNGRSV------- 73

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 116008086   1701 eSM-VDPTPAFSTDIDQAAfqSLIATSTQVYLGGMPESRQARGSTLSaqqgSQFKGCVGEARV 1762
Cdd:smart00282   74 -TLsVDGGNRVSGESPGGL--TILNLDGPLYLGGLPEDLKLPPLPVT----PGFRGCIRNLKV 129
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 766-801 1.15e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 1.15e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 116008086  766 DIDECGS-NPCSNGSTCIDRINNFTCNCIPGMTGRIC 801
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1624-1762 1.15e-06

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 50.11  E-value: 1.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116008086 1624 IDIAFRTR-AGGTLLYIDN--VDGFFEIGVNGGRVTITWKLSAlhfgESARFEKENT--DGEWSRIYLRAHNSKLeggwk 1698
Cdd:cd00110    24 ISFSFRTTsPNGLLLYAGSqnGGDFLALELEDGRLVLRYDLGS----GSLVLSSKTPlnDGQWHSVSVERNGRSV----- 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 116008086 1699 gweSM-VDPTPAFstDIDQAAFQSLIATSTQVYLGGMPESRQARGSTLSAqqgsQFKGCVGEARV 1762
Cdd:cd00110    95 ---TLsVDGERVV--ESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSP----GFVGCIRDLKV 150
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 843-879 2.06e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 2.06e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 116008086  843 NIDECLS-NPCTNGAKCLDRVKDYFCDCHNGYKGKNCE 879
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1875-1910 2.54e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.54e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 116008086 1875 NIDECADQ-PCHNGGNCTDLIASYVCDCPEDYMGPQC 1910
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 804-841 3.06e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 3.06e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 116008086  804 DIDDCV-GDPCLNGGQCIDQLGGFRCDCSgTGYEGENCE 841
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 425-460 3.15e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 3.15e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 116008086  425 NVDECD-KNPCLNGGRCFDTYGWYTCQCLDGWGGEIC 460
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
1993-2030 3.32e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 3.32e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 116008086   1993 DINECES-NPCQNGGQCKDLVGRYECDCQGTGFEGIRCE 2030
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
945-981 3.36e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 3.36e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 116008086    945 NINECDS-NPCSKHGNCNDGIGTYTCECEPGFE-GTHCE 981
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1529-1558 5.40e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 5.40e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 116008086 1529 NPCLHNAECRNTWNDYTCKCPNGYKGKNCQ 1558
Cdd:cd00054     9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 386-423 5.56e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 5.56e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 116008086  386 DTDECASQ-PCQNNGSCIDRINGFSCDCSgTGYTGAFCQ 423
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1526-1556 8.36e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 44.30  E-value: 8.36e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 116008086  1526 CRKNPCLHNAECRNTWNDYTCKCPNGYKGKN 1556
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
1837-1873 9.68e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 9.68e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 116008086   1837 DIDECL-NTECLNNGTCINQVAAFFCQCQPGFE-GQHCE 1873
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
766-802 1.60e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 1.60e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 116008086    766 DIDECGS-NPCSNGSTCIDRINNFTCNCIPGMT-GRICD 802
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
804-841 2.77e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 2.77e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 116008086    804 DIDDCV-GDPCLNGGQCIDQLGGFRCDCSGTGYEGENCE 841
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1875-1911 2.85e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 2.85e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 116008086   1875 NIDECA-DQPCHNGGNCTDLIASYVCDCPEDYM-GPQCD 1911
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 689-725 4.41e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 4.41e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 116008086  689 DVDECTLHPKICGNGICKNEKGSYKCYCTPGFTGVHC 725
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
843-879 5.09e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 5.09e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 116008086    843 NIDECLS-NPCTNGAKCLDRVKDYFCDCHNGYK-GKNCE 879
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
425-455 5.72e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 5.72e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 116008086    425 NVDEC-DKNPCLNGGRCFDTYGWYTCQCLDGW 455
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
386-423 1.40e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.40e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 116008086    386 DTDECAS-QPCQNNGSCIDRINGFSCDCSGTGYTGAFCQ 423
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 983-1018 1.48e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 1.48e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 116008086  983 NIDECDRYNPCQR-GTCYDQIDDYDCDCDANYGGKNC 1018
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 652-686 1.81e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 1.81e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 116008086  652 NQCATQ-PCQNGGECVDLPNGdYECKCTRGWTGRTC 686
Cdd:cd00054     3 DECASGnPCQNGGTCVNTVGS-YRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 429-458 4.67e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 4.67e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 116008086   429 CDKNPCLNGGRCFDTYGWYTCQCLDGWGGE 458
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 949-977 6.09e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 6.09e-04
                           10        20
                   ....*....|....*....|....*....
gi 116008086   949 CDSNPCSKHGNCNDGIGTYTCECEPGFEG 977
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 847-877 6.72e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 6.72e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 116008086   847 CLSNPCTNGAKCLDRVKDYFCDCHNGYKGKN 877
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 466-495 6.99e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 6.99e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 116008086   466 CQTQQCLNGGTCLDKPIGFQCLCPPEYTGE 495
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2032-2069 7.77e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 7.77e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 116008086 2032 DIDECNmEGDYCGGLGRCFNKPGSFQCICQKPYCGAYC 2069
Cdd:cd00054     1 DIDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 732-762 1.11e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 1.11e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 116008086   732 CLSFPCLNGATCHNKINAYECVCQPGYEGEN 762
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
2032-2069 1.11e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.11e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 116008086   2032 DIDECNmEGDYCGGLGRCFNKPGSFQCICQKPY-CGAYC 2069
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYtDGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1528-1558 1.11e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.11e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 116008086   1528 KNPCLHNAECRNTWNDYTCKCPNGYK-GKNCQ 1558
Cdd:smart00179    8 GNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1252-1282 1.40e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 1.40e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 116008086  1252 CKPNPCHSNGECTDLWHTFACHCPRPFFGHT 1282
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 471-498 2.04e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 2.04e-03
                          10        20
                  ....*....|....*....|....*...
gi 116008086  471 CLNGGTCLDKPIGFQCLCPPEYTGELCQ 498
Cdd:cd00054    11 CQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
689-726 2.33e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 2.33e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 116008086    689 DVDECTLHPkICGNG-ICKNEKGSYKCYCTPGFT-GVHCD 726
Cdd:smart00179    1 DIDECASGN-PCQNGgTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 654-685 2.82e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 2.82e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 116008086   654 CATQPCQNGGECVDLPnGDYECKCTRGWTGRT 685
Cdd:pfam00008    1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
983-1018 3.85e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 3.85e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 116008086    983 NIDECDRYNPCQRG-TCYDQIDDYDCDCDANY-GGKNC 1018
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYtDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2073-2111 4.14e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 4.14e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 116008086 2073 DPCNATDLCSNGGRCVESCGakpDYYCECPEGFAGKNCT 2111
Cdd:cd00054     3 DECASGNPCQNGGTCVNTVG---SYRCSCPPGYTGRNCE 38
EGF_CA pfam07645
Calcium-binding EGF domain;
689-719 4.19e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 4.19e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 116008086   689 DVDECTLHPKIC-GNGICKNEKGSYKCYCTPG 719
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 269-299 4.44e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 4.44e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 116008086   269 CLNDPCMGHGTCSSSPEGYECRCTARYSGKN 299
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1997-2028 4.53e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 4.53e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 116008086  1997 CESNPCQNGGQCKDLVGRYECDCQgTGFEGIR 2028
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 311-341 5.51e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 5.51e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 116008086  311 NPCENGGSClENSRGDYQCFCDPNHSGQHCE 341
Cdd:cd00054     9 NPCQNGGTC-VNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1254-1284 7.63e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 7.63e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 116008086 1254 PNPCHSNGECTDLWHTFACHCPRPFFGHTCQ 1284
Cdd:cd00054     8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
652-686 8.99e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 8.99e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 116008086    652 NQCAT-QPCQNGGECVDLPNGdYECKCTRGWT-GRTC 686
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGS-YRCECPPGYTdGRNC 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1959-1988 9.38e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 9.38e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 116008086  1959 CEITPCDNGGLCLTTGAVPMCKCSLGYTGR 1988
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
 
Name Accession Description Interval E-value
Laminin_G_1 pfam00054
Laminin G domain;
1091-1226 1.30e-36

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 135.52  E-value: 1.30e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116008086  1091 FRTTLPNGVLAFGttGEKNEPVSYILELINGRLNLHSSLLNKWEGVFIGSKLNDSNWHKVFVAINTSHLVLSANDEQaiF 1170
Cdd:pfam00054    1 FRTTEPSGLLLYN--GTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEA--R 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 116008086  1171 PVGSYETANNSQPSFPRTYLGGTIPNLKSYLRHLTHQPSaFVGCMQDIMVNGKWIF 1226
Cdd:pfam00054   77 PTGESPLGATTDLDVDGPLYVGGLPSLGVKKRRLAISPS-FDGCIRDVIVNGKPLD 131
Laminin_G_1 pfam00054
Laminin G domain;
1324-1486 2.70e-25

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 103.17  E-value: 2.70e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116008086  1324 IRTREPTGQVFYLGTDPRKAptknigdsYVAAKLHGGELLVKMQFSGTPeAYTVGGQKLDNGYNHLIEVVRNQTLVQVKL 1403
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERD--------FLALELRDGRLEVSYDLGSGA-AVVRSGDKLNDGKWHSVELERNGRSGTLSV 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116008086  1404 NGTEyfrktlsttglldaqvlylggpAPTRESLLGATTepgIIPVPGA----GIPIEdtTVPKEADDSRDYFKGIIQDVK 1479
Cdd:pfam00054   72 DGEA----------------------RPTGESPLGATT---DLDVDGPlyvgGLPSL--GVKKRRLAISPSFDGCIRDVI 124


                   ....*..
gi 116008086  1480 VSNGSLN 1486
Cdd:pfam00054  125 VNGKPLD 131
LamG smart00282
Laminin G domain;
1086-1223 4.83e-22

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 93.94  E-value: 4.83e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116008086   1086 DINLQFRTTLPNGVLAFGTTGEKNEPVSyiLELINGRLNLHSSLLNKWEGVFIGS-KLNDSNWHKVFVAINTSHLVLSAN 1164
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLA--LELRDGRLVLRYDLGSGPARLTSDPtPLNDGQWHRVAVERNGRSVTLSVD 78

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 116008086   1165 DE--QAIFPVGSYETANnsqpSFPRTYLGGTIPNLKSYLRHLTHqpsAFVGCMQDIMVNGK 1223
Cdd:smart00282   79 GGnrVSGESPGGLTILN----LDGPLYLGGLPEDLKLPPLPVTP---GFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1072-1221 7.81e-20

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 88.24  E-value: 7.81e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116008086 1072 TSLISVTTEREEG--YDINLQFRTTLPNGVLAFGTTGEKNEpvSYILELINGRLNLHSSLLnkWEGVFIGSK--LNDSNW 1147
Cdd:cd00110     7 SSYVRLPTLPAPRtrLSISFSFRTTSPNGLLLYAGSQNGGD--FLALELEDGRLVLRYDLG--SGSLVLSSKtpLNDGQW 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 116008086 1148 HKVFVAINTSHLVLSANDEQAI-FPVGSYETANNSQPSFprtYLGGTIPNLKSYLRHLTHqpsAFVGCMQDIMVN 1221
Cdd:cd00110    83 HSVSVERNGRSVTLSVDGERVVeSGSPGGSALLNLDGPL---YLGGLPEDLKSPGLPVSP---GFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1091-1223 3.54e-16

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 76.69  E-value: 3.54e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116008086  1091 FRTTLPNGVLAFgTTGEKNEPVSyiLELINGRLNLHSSLLNKWEGVF-IGSKLNDSNWHKVFVAINTSHLVLSANDEQAI 1169
Cdd:pfam02210    1 FRTRQPNGLLLY-AGGGGSDFLA--LELVNGRLVLRYDLGSGPESLLsSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVV 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 116008086  1170 FPVGSYETANNSQPSfpRTYLGGTIPNLksyLRHLTHQPSAFVGCMQDIMVNGK 1223
Cdd:pfam02210   78 SSLPPGESLLLNLNG--PLYLGGLPPLL---LLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
1319-1482 8.00e-15

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 73.14  E-value: 8.00e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116008086   1319 DISMFIRTREPTGQVFYLGTDPrkaptkniGDSYVAAKLHGGELLVKMQFSGTPEAYTVGGQKLDNGYNHLIEVVRNQTL 1398
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKG--------GGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRS 72

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116008086   1399 VQVKLNGTE--YFRKTLSTTGLLDAQVLYLGGPAPTRESLLGATTEPgiipvpgagipiedttvpkeaddsrdyFKGIIQ 1476
Cdd:smart00282   73 VTLSVDGGNrvSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTPG---------------------------FRGCIR 125


                    ....*.
gi 116008086   1477 DVKVSN 1482
Cdd:smart00282  126 NLKVNG 131
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1312-1480 1.15e-13

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 70.52  E-value: 1.15e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116008086 1312 RAIRSILDISMFIRTREPTGQVFYLGTDPrkaptkniGDSYVAAKLHGGEllVKMQFSGTPEAYTVG-GQKLDNGYNHLI 1390
Cdd:cd00110    16 PAPRTRLSISFSFRTTSPNGLLLYAGSQN--------GGDFLALELEDGR--LVLRYDLGSGSLVLSsKTPLNDGQWHSV 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116008086 1391 EVVRNQTLVQVKLNGTEYFRKTLSTTG--LLDAQVLYLGGPAPTRESLLGATtepgiipvpgagipiedttvpkeaddsR 1468
Cdd:cd00110    86 SVERNGRSVTLSVDGERVVESGSPGGSalLNLDGPLYLGGLPEDLKSPGLPV---------------------------S 138

                         170
                  ....*....|..
gi 116008086 1469 DYFKGIIQDVKV 1480
Cdd:cd00110   139 PGFVGCIRDLKV 150
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1628-1764 1.91e-09

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 57.43  E-value: 1.91e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116008086  1628 FRTRAG-GTLLYIDNVDG-FFEIGVNGGRVTITWKLSALHFGESARfEKENTDGEWSRIYLRAHNSKLeggwkgwESMVD 1705
Cdd:pfam02210    1 FRTRQPnGLLLYAGGGGSdFLALELVNGRLVLRYDLGSGPESLLSS-GKNLNDGQWHSVRVERNGNTL-------TLSVD 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 116008086  1706 PTPAFSTDIDQaaFQSLIATSTQVYLGGMPESRqaRGSTLSAQQGsqFKGCVGEARVGD 1764
Cdd:pfam02210   73 GQTVVSSLPPG--ESLLLNLNGPLYLGGLPPLL--LLPALPVRAG--FVGCIRDVRVNG 125
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 728-764 1.19e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.64  E-value: 1.19e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 116008086  728 DVDECLSF-PCLNGATCHNKINAYECVCQPGYEGENCE 764
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 945-981 1.03e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 1.03e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 116008086  945 NINECDS-NPCSKHGNCNDGIGTYTCECEPGFEGTHCE 981
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 91-228 1.11e-07

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 53.19  E-value: 1.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116008086   91 AYFNGSTYLRLTTPMPIWDHSAISF----RSCRGgeIL---AQQYNKNSIVISVLNDFLQISlagpaVHGPNNRLDVKLP 163
Cdd:cd00110     2 VSFSGSSYVRLPTLPAPRTRLSISFsfrtTSPNG--LLlyaGSQNGGDFLALELEDGRLVLR-----YDLGSGSLVLSSK 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 116008086  164 YQLLDNRWHTLQFKYEYGNLYLHVDRAASI-FANSTYNSQFLTNQDI-------GYKDAILILGNSFSGCLLD 228
Cdd:cd00110    75 TPLNDGQWHSVSVERNGRSVTLSVDGERVVeSGSPGGSALLNLDGPLylgglpeDLKSPGLPVSPGFVGCIRD 147
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1324-1482 1.22e-07

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 52.42  E-value: 1.22e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116008086  1324 IRTREPTGQVFYLGtdprkaptkNIGDSYVAAKLHGGELLVKMQFSGTPEAYTVGGQKLDNGYNHLIEVVRNQTLVQVKL 1403
Cdd:pfam02210    1 FRTRQPNGLLLYAG---------GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSV 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116008086  1404 NG--TEYFRKTLSTTGLLDAQVLYLGGPAPTResllgattepgiipvpgagipiedttvPKEADDSRDYFKGIIQDVKVS 1481
Cdd:pfam02210   72 DGqtVVSSLPPGESLLLNLNGPLYLGGLPPLL---------------------------LLPALPVRAGFVGCIRDVRVN 124


                   .
gi 116008086  1482 N 1482
Cdd:pfam02210  125 G 125
EGF_CA smart00179
Calcium-binding EGF-like domain;
728-764 1.56e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.17  E-value: 1.56e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 116008086    728 DVDECLSF-PCLNGATCHNKINAYECVCQPGYE-GENCE 764
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1837-1873 2.85e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 2.85e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 116008086 1837 DIDECLNTE-CLNNGTCINQVAAFFCQCQPGFEGQHCE 1873
Cdd:cd00054     1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1993-2030 2.96e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 2.96e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 116008086 1993 DINECES-NPCQNGGQCKDLVGRYECDCQgTGFEGIRCE 2030
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
LamG smart00282
Laminin G domain;
1624-1762 3.68e-07

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 51.19  E-value: 3.68e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116008086   1624 IDIAFRTRAG-GTLLYIDNVDG--FFEIGVNGGRVTITWKLSALHFGESARFEKENtDGEWSRIYLRAHNSKLeggwkgw 1700
Cdd:smart00282    2 ISFSFRTTSPnGLLLYAGSKGGgdYLALELRDGRLVLRYDLGSGPARLTSDPTPLN-DGQWHRVAVERNGRSV------- 73

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 116008086   1701 eSM-VDPTPAFSTDIDQAAfqSLIATSTQVYLGGMPESRQARGSTLSaqqgSQFKGCVGEARV 1762
Cdd:smart00282   74 -TLsVDGGNRVSGESPGGL--TILNLDGPLYLGGLPEDLKLPPLPVT----PGFRGCIRNLKV 129
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 766-801 1.15e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 1.15e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 116008086  766 DIDECGS-NPCSNGSTCIDRINNFTCNCIPGMTGRIC 801
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1624-1762 1.15e-06

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 50.11  E-value: 1.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116008086 1624 IDIAFRTR-AGGTLLYIDN--VDGFFEIGVNGGRVTITWKLSAlhfgESARFEKENT--DGEWSRIYLRAHNSKLeggwk 1698
Cdd:cd00110    24 ISFSFRTTsPNGLLLYAGSqnGGDFLALELEDGRLVLRYDLGS----GSLVLSSKTPlnDGQWHSVSVERNGRSV----- 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 116008086 1699 gweSM-VDPTPAFstDIDQAAFQSLIATSTQVYLGGMPESRQARGSTLSAqqgsQFKGCVGEARV 1762
Cdd:cd00110    95 ---TLsVDGERVV--ESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSP----GFVGCIRDLKV 150
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 843-879 2.06e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 2.06e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 116008086  843 NIDECLS-NPCTNGAKCLDRVKDYFCDCHNGYKGKNCE 879
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1875-1910 2.54e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.54e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 116008086 1875 NIDECADQ-PCHNGGNCTDLIASYVCDCPEDYMGPQC 1910
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 804-841 3.06e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 3.06e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 116008086  804 DIDDCV-GDPCLNGGQCIDQLGGFRCDCSgTGYEGENCE 841
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 425-460 3.15e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 3.15e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 116008086  425 NVDECD-KNPCLNGGRCFDTYGWYTCQCLDGWGGEIC 460
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
1993-2030 3.32e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 3.32e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 116008086   1993 DINECES-NPCQNGGQCKDLVGRYECDCQGTGFEGIRCE 2030
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
945-981 3.36e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 3.36e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 116008086    945 NINECDS-NPCSKHGNCNDGIGTYTCECEPGFE-GTHCE 981
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1529-1558 5.40e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 5.40e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 116008086 1529 NPCLHNAECRNTWNDYTCKCPNGYKGKNCQ 1558
Cdd:cd00054     9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 386-423 5.56e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 5.56e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 116008086  386 DTDECASQ-PCQNNGSCIDRINGFSCDCSgTGYTGAFCQ 423
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1526-1556 8.36e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 44.30  E-value: 8.36e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 116008086  1526 CRKNPCLHNAECRNTWNDYTCKCPNGYKGKN 1556
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
1837-1873 9.68e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 9.68e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 116008086   1837 DIDECL-NTECLNNGTCINQVAAFFCQCQPGFE-GQHCE 1873
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
766-802 1.60e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 1.60e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 116008086    766 DIDECGS-NPCSNGSTCIDRINNFTCNCIPGMT-GRICD 802
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
804-841 2.77e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 2.77e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 116008086    804 DIDDCV-GDPCLNGGQCIDQLGGFRCDCSGTGYEGENCE 841
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1875-1911 2.85e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 2.85e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 116008086   1875 NIDECA-DQPCHNGGNCTDLIASYVCDCPEDYM-GPQCD 1911
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 689-725 4.41e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 4.41e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 116008086  689 DVDECTLHPKICGNGICKNEKGSYKCYCTPGFTGVHC 725
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
843-879 5.09e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 5.09e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 116008086    843 NIDECLS-NPCTNGAKCLDRVKDYFCDCHNGYK-GKNCE 879
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
425-455 5.72e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 5.72e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 116008086    425 NVDEC-DKNPCLNGGRCFDTYGWYTCQCLDGW 455
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
386-423 1.40e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.40e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 116008086    386 DTDECAS-QPCQNNGSCIDRINGFSCDCSGTGYTGAFCQ 423
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 983-1018 1.48e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 1.48e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 116008086  983 NIDECDRYNPCQR-GTCYDQIDDYDCDCDANYGGKNC 1018
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 652-686 1.81e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 1.81e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 116008086  652 NQCATQ-PCQNGGECVDLPNGdYECKCTRGWTGRTC 686
Cdd:cd00054     3 DECASGnPCQNGGTCVNTVGS-YRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 429-458 4.67e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 4.67e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 116008086   429 CDKNPCLNGGRCFDTYGWYTCQCLDGWGGE 458
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 949-977 6.09e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 6.09e-04
                           10        20
                   ....*....|....*....|....*....
gi 116008086   949 CDSNPCSKHGNCNDGIGTYTCECEPGFEG 977
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 847-877 6.72e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 6.72e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 116008086   847 CLSNPCTNGAKCLDRVKDYFCDCHNGYKGKN 877
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 466-495 6.99e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 6.99e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 116008086   466 CQTQQCLNGGTCLDKPIGFQCLCPPEYTGE 495
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2032-2069 7.77e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 7.77e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 116008086 2032 DIDECNmEGDYCGGLGRCFNKPGSFQCICQKPYCGAYC 2069
Cdd:cd00054     1 DIDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 732-762 1.11e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 1.11e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 116008086   732 CLSFPCLNGATCHNKINAYECVCQPGYEGEN 762
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
2032-2069 1.11e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.11e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 116008086   2032 DIDECNmEGDYCGGLGRCFNKPGSFQCICQKPY-CGAYC 2069
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYtDGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1528-1558 1.11e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.11e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 116008086   1528 KNPCLHNAECRNTWNDYTCKCPNGYK-GKNCQ 1558
Cdd:smart00179    8 GNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1252-1282 1.40e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 1.40e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 116008086  1252 CKPNPCHSNGECTDLWHTFACHCPRPFFGHT 1282
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 471-498 2.04e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 2.04e-03
                          10        20
                  ....*....|....*....|....*...
gi 116008086  471 CLNGGTCLDKPIGFQCLCPPEYTGELCQ 498
Cdd:cd00054    11 CQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
689-726 2.33e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 2.33e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 116008086    689 DVDECTLHPkICGNG-ICKNEKGSYKCYCTPGFT-GVHCD 726
Cdd:smart00179    1 DIDECASGN-PCQNGgTCVNTVGSYRCECPPGYTdGRNCE 39
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1529-1558 2.38e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.46  E-value: 2.38e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 116008086 1529 NPCLHNAECRNTWNDYTCKCPNGYKG-KNCQ 1558
Cdd:cd00053     6 NPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 654-685 2.82e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 2.82e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 116008086   654 CATQPCQNGGECVDLPnGDYECKCTRGWTGRT 685
Cdd:pfam00008    1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
983-1018 3.85e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 3.85e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 116008086    983 NIDECDRYNPCQRG-TCYDQIDDYDCDCDANY-GGKNC 1018
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYtDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2073-2111 4.14e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 4.14e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 116008086 2073 DPCNATDLCSNGGRCVESCGakpDYYCECPEGFAGKNCT 2111
Cdd:cd00054     3 DECASGNPCQNGGTCVNTVG---SYRCSCPPGYTGRNCE 38
EGF_CA pfam07645
Calcium-binding EGF domain;
689-719 4.19e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 4.19e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 116008086   689 DVDECTLHPKIC-GNGICKNEKGSYKCYCTPG 719
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 269-299 4.44e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 4.44e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 116008086   269 CLNDPCMGHGTCSSSPEGYECRCTARYSGKN 299
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1997-2028 4.53e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 4.53e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 116008086  1997 CESNPCQNGGQCKDLVGRYECDCQgTGFEGIR 2028
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 311-341 5.51e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 5.51e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 116008086  311 NPCENGGSClENSRGDYQCFCDPNHSGQHCE 341
Cdd:cd00054     9 NPCQNGGTC-VNTVGSYRCSCPPGYTGRNCE 38
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 731-764 5.60e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.30  E-value: 5.60e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 116008086  731 ECLSF-PCLNGATCHNKINAYECVCQPGYEGE-NCE 764
Cdd:cd00053     1 ECAASnPCSNGGTCVNTPGSYRCVCPPGYTGDrSCE 36
EGF_CA pfam07645
Calcium-binding EGF domain;
728-757 6.66e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 6.66e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 116008086   728 DVDECLSFP--CLNGATCHNKINAYECVCQPG 757
Cdd:pfam07645    1 DVDECATGThnCPANTVCVNTIGSFECRCPDG 32
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 948-981 6.89e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.30  E-value: 6.89e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 116008086  948 ECD-SNPCSKHGNCNDGIGTYTCECEPGFEG-THCE 981
Cdd:cd00053     1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1254-1284 7.63e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 7.63e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 116008086 1254 PNPCHSNGECTDLWHTFACHCPRPFFGHTCQ 1284
Cdd:cd00054     8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 737-758 8.27e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 35.77  E-value: 8.27e-03
                           10        20
                   ....*....|....*....|..
gi 116008086   737 CLNGATCHNKINAYECVCQPGY 758
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF_CA smart00179
Calcium-binding EGF-like domain;
652-686 8.99e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 8.99e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 116008086    652 NQCAT-QPCQNGGECVDLPNGdYECKCTRGWT-GRTC 686
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGS-YRCECPPGYTdGRNC 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1959-1988 9.38e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 9.38e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 116008086  1959 CEITPCDNGGLCLTTGAVPMCKCSLGYTGR 1988
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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