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Conserved domains on  [gi|109633046|ref|NP_001035902|]
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lactosylceramide alpha-2,3-sialyltransferase isoform 2 [Homo sapiens]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 168-378 2.02e-155

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467711  Cd Length: 211  Bit Score: 436.48  E-value: 2.02e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 168 TCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVD 247
Cdd:cd23983    1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 248 FNWLQAMVKKETLPFWVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGRDKNVPTIGVIAVVLAT 327
Cdd:cd23983   81 FAWLKAMVKKEPLSFWSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYPEPQSRLWGWDKNVPTLGVTAVVLAT 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 109633046 328 HLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKL 378
Cdd:cd23983  161 HLCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
 
Name Accession Description Interval E-value
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 168-378 2.02e-155

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 436.48  E-value: 2.02e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 168 TCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVD 247
Cdd:cd23983    1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 248 FNWLQAMVKKETLPFWVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGRDKNVPTIGVIAVVLAT 327
Cdd:cd23983   81 FAWLKAMVKKEPLSFWSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYPEPQSRLWGWDKNVPTLGVTAVVLAT 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 109633046 328 HLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKL 378
Cdd:cd23983  161 HLCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 133-383 1.22e-92

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 278.72  E-value: 1.22e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046  133 SKYDPPFgfrkfsSKVQTLLELLPEhdlPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVG 212
Cdd:pfam00777  16 SEWWLPF------TVTEELLELLPK---VSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046  213 NKTTIRMTYPEGAPLSDL-------EYYSNDLFVAVLFKSVDFNWLQAMVKKETLPF-WVRLFFWKQVaeKIPLQPKHFR 284
Cdd:pfam00777  87 SKTTLRTMNPESAIDSKYgnlgfshPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRsLRVLYTLKEV--KIPVDPDKVL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046  285 ILNPVIIKETAFDILQYSEPQSRfwgrdknVPTIGVIAVVLATHLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQT 364
Cdd:pfam00777 165 FLHPDFLRYVANFWLRSHGLKGR-------RPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGGFYG 237

                         250
                  ....*....|....*....
gi 109633046  365 MHNVTTETKFLLKLVKEGV 383
Cdd:pfam00777 238 VHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 168-378 2.02e-155

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 436.48  E-value: 2.02e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 168 TCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVD 247
Cdd:cd23983    1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 248 FNWLQAMVKKETLPFWVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGRDKNVPTIGVIAVVLAT 327
Cdd:cd23983   81 FAWLKAMVKKEPLSFWSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYPEPQSRLWGWDKNVPTLGVTAVVLAT 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 109633046 328 HLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKL 378
Cdd:cd23983  161 HLCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 168-378 1.89e-120

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 347.36  E-value: 1.89e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 168 TCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVD 247
Cdd:cd23967    1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDPEEYDSDWLLVLVPFKSMD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 248 FNWLQAMVKKETLPFWVrlFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQsrfwGRDKNVPTIGVIAVVLAT 327
Cdd:cd23967   81 LLWLQAVIKGKKPNGKG--GFWKKIATSVPKPPKKIRILNPYILQEAAFDLIGLPMNG----KQGKNVPTTGIIAIVMAL 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 109633046 328 HLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKL 378
Cdd:cd23967  155 HYCDEVDIAGFGYDPSDPNAPLHYYDSLTMKAIKRSWTHNVTKEKKYLKKL 205
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 133-383 1.22e-92

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 278.72  E-value: 1.22e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046  133 SKYDPPFgfrkfsSKVQTLLELLPEhdlPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVG 212
Cdd:pfam00777  16 SEWWLPF------TVTEELLELLPK---VSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046  213 NKTTIRMTYPEGAPLSDL-------EYYSNDLFVAVLFKSVDFNWLQAMVKKETLPF-WVRLFFWKQVaeKIPLQPKHFR 284
Cdd:pfam00777  87 SKTTLRTMNPESAIDSKYgnlgfshPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRsLRVLYTLKEV--KIPVDPDKVL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046  285 ILNPVIIKETAFDILQYSEPQSRfwgrdknVPTIGVIAVVLATHLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQT 364
Cdd:pfam00777 165 FLHPDFLRYVANFWLRSHGLKGR-------RPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGGFYG 237

                         250
                  ....*....|....*....
gi 109633046  365 MHNVTTETKFLLKLVKEGV 383
Cdd:pfam00777 238 VHDMPFEFKLLQKLHKEGV 256
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 168-378 5.13e-70

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 219.02  E-value: 5.13e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 168 TCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVD 247
Cdd:cd23981    1 SCRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 248 FNWLQAMVKKETlpfwVRLF--FWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEpQSRFWGRDkNVPTIGVIAVVL 325
Cdd:cd23981   81 FKWLKYIVYKEK----VSASdgFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPF-NNGLMGRG-NIPTLGSVAITM 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 109633046 326 ATHLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKL 378
Cdd:cd23981  155 ALHNCDEVAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLRKL 207
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 168-378 1.14e-65

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 207.59  E-value: 1.14e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 168 TCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSND-LFVAVLFKSV 246
Cdd:cd23982    1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPGIENDPDtLLVLVPFKPL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 247 DFNWLQAMVKKETLpfwVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQSrfwgrDKNVPTIGVIAVVLA 326
Cdd:cd23982   81 DFYWLYEILSNEKR---VRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVPGQRK-----KKQKPTTGLLAITLA 152

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 109633046 327 THLCDEVSLAGFGYDLNQ-PRTPLHYFDSQCMAAM-NFQtmHNVTTETKFLLKL 378
Cdd:cd23982  153 LHLCDEVHIAGFGYPDNGnSNQPIHYYNQITLKSMaNSG--HNLNAEAQAIQRL 204
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 169-378 3.04e-58

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 188.80  E-value: 3.04e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 169 CRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVDF 248
Cdd:cd23984    2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 249 NWL-QAMVKKETLPFWvrlfFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEpqsRFWGRDKNV-PTIGVIAVVLA 326
Cdd:cd23984   82 RWLlDLLMGKKVSAKG----FWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPK---RFPKEKKPKhPTTGIIAITLA 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 109633046 327 THLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKL 378
Cdd:cd23984  155 LHICNEVHIAGFKYDFSNLNSTLHYYGNETMSVMTKNEYHNISAEQKFLKDL 206
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 133-385 1.33e-38

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 140.09  E-value: 1.33e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 133 SKYDPPFGFRKFS-SKVQTLLELL--PEHDLPEHLKA--KTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGY 207
Cdd:cd23964   41 SHYKLPFGWGGLNrEVVERLLRNLnlTSSRYMFVLRGgrPRCIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGF 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 208 SEHVGNKTTIRMTYPEGAPLSDLEYYSND---LFVAVLFKSVDFNWLQAMVKKETLPFWVRLFFWKQVAEKIPLQPKHFR 284
Cdd:cd23964  121 EKDVGTKTSFYTFFPESLHNSLLKHVPQDkdtKYLFIPFKIRDYDYLDAVLSGKPVPDGCDKGKRPPPLFGPKLNATNVR 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 285 ILNPviiketafDILQYSEpqsRFWGRDKNV--PTIGVIAVVLATHLCDEVSLAGFGYDlnqPRTPLHYFDSQCMAAMNF 362
Cdd:cd23964  201 LLHP--------DFIRYLF---NRWLNSSTSyrPTTGALMLLTALHTCDQVSVYGFGYD---PRFSLHYYDKTFVKFTVF 266

                        250       260
                 ....*....|....*....|...
gi 109633046 363 QTMHNVTTETKFLLKLVKEGVVK 385
Cdd:cd23964  267 YANHDFTNERKLWRKLHEEGIIN 289
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 172-378 6.90e-30

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 114.00  E-value: 6.90e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 172 CVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPlsdlEYYSNDLFVAVLFKSVDFNWL 251
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAG----FYLRGPRCGCHPLPLEEEVVL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 252 QAMVKKETLPFWVRLFFWKQVAEKIPLQPKHFRILNpviiketAFDILQYSEpqSRFWGRDKNVPTIGVIAVVLATHLCD 331
Cdd:cd19952   77 ILSRAAAADFKRLKRRKKRHDNAVLLLTDPAPDLLS-------YVRKRLEKL--GLKSFFGGNAPSSGLLAVLLALQLCD 147

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 109633046 332 EVSLAGFGYD-LNQPRTPLHYFDsqCMAAMNFQTMHNVTTETKFLLKL 378
Cdd:cd19952  148 SVDLYGFGVDsGHAPKVPYHYYD--LVEAEEGTAVHSFDLEAELLRAL 193
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 148-385 5.61e-29

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 113.91  E-value: 5.61e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 148 VQTLLELLPEHDLPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPL 227
Cdd:cd23966   56 LEKLFQVVPGENPYRTRDPNRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESAVD 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 228 SDLEYYsndlFVAVLFKSVDFNWLQAMVKKETLpfwvrLFFWKQVAEKIPLQPKHFRILNPVIIKETAFdilQYSEPQSR 307
Cdd:cd23966  136 LDPGVH----LVLVPFKVLDLQWLISALTTGEI-----TRTYTPVKRFIKADKDKVLVINPAFIKYVHD---NWTEHHGR 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 308 FwgrdknvPTIGVIAVVLATHLCDEVSLAGFGYDLNQPRTplHYFDSQcMAAMNFQ--TMHNVTTETKFLLKLVKEGVVK 385
Cdd:cd23966  204 Y-------PSTGFLALIFALHICDEVSVFGFGADSKGNWH--HYWEKN-RSAGAFRktGVHDADFESDIIKKLAKEGKIR 273
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 97-385 2.68e-23

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 98.40  E-value: 2.68e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046  97 CRPKFAKTSMALLFEHRYSVDLLPFVQKAPKDSEAESKY-----DPPFGFRKFSSKVQTLLELLPEHDLPEHLKAKTCRR 171
Cdd:cd23979    3 CRRCVGDPGVSDWFDEHYDPDISPVWTKENMELPPDVQYwwmmlQPQFKPHNTKEVLSKLFQIIPGENPYRSWDPSRCRR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 172 CVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPlsdlEYYSNDLFVAVLFKSVDFNWL 251
Cdd:cd23979   83 CAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAK----NLPANVSFVLVPFKTLDLLWI 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 252 QAMVKKETLPfwvrlFFWKQVAEKIPLQPKHFRILNPVIIKetaFDILQYSEPQSRFwgrdknvPTIGVIAVVLATHLCD 331
Cdd:cd23979  159 TSALSTGQIR-----FTYAPVKQFLRVDKDKVQIYNPAFFK---YIHDRWTEHHGRY-------PSTGMLVLFFALHVCD 223

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 109633046 332 EVSLAGFGYDlnqPRTPLHYFDSQCMAAMNFQT--MHNVTTETKFLLKLVKEGVVK 385
Cdd:cd23979  224 EVNVYGFGAD---SRGNWHHYWENNRYAGEFRKtgVHDADFEAHIIDMLAKAGKIK 276
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 149-385 1.28e-22

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 96.18  E-value: 1.28e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 149 QTLLELLPEHDLPEHlkaKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKT--------TIRMT 220
Cdd:cd23963   46 KSLYELLPKTSPFSH---KRYKTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTnlttlnpsILKRR 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 221 YPEGAP-------LSDLEYYSNDLFVAVLFKsvdFNWLQAMVKKetlpfwvrlffwkqVAEKIPLQPKHFRIlnpviike 293
Cdd:cd23963  123 YNSLKKnrdrdkfLNRLKEYNGSILWYPKFS---FKSSTNLLLK--------------AARALKKNGLNLTV-------- 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 294 tAFDILQYSEPQSRFWGRDKN--VPTIGVIAVVLATHLCDEVSLAGF---GYDLNQPRTPLHYFDSqcMAAMNFQTMHNV 368
Cdd:cd23963  178 -VYSNPEHFLAVQKFWKRRGLekRPSTGLYLVSLALTFCDEIHLYGFwpfPTDPNGRPVPYHYYDD--LSPSTKNKVHNM 254

                        250
                 ....*....|....*..
gi 109633046 369 TTETKFLLKLVKEGVVK 385
Cdd:cd23963  255 PEEFKLLRELHKKGVLK 271
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 148-341 1.13e-21

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 93.79  E-value: 1.13e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 148 VQTLLELLP-EHDLPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEgap 226
Cdd:cd23980   59 IRELFQVVPgNVDPLLEKRLVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPE--- 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 227 lSDLEYYSNDLFVAVLFKSVDFNWLQAMVKKETLPfwvrlFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSepqs 306
Cdd:cd23980  136 -SFRELAQNVSMILVPFKTLDLEWVISATTTGTIS-----HTYVPVPRKIKVKKEKILIYHPAFIKYVFDRWLQGH---- 205

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 109633046 307 rfwGRdknVPTIGVIAVVLATHLCDEVSLAGFGYD 341
Cdd:cd23980  206 ---GR---YPSTGILSVIFSLHVCDEVDLYGFGAD 234
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 115-378 2.58e-20

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 89.64  E-value: 2.58e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 115 SVDLLPFVQKAPKDSEAEsKYDPPFGFRKFSskvqtlLELLPEHDLpehLKAKTCRRCVVIGSGGILHGLELGHTLNQFD 194
Cdd:cd23968    1 SEDLLCRLKKAAPFSTLR-KTTSPFKDLLSL------RYPFPESSL---ENTKRYNTCAVVSSSGALLGSKLGKEIDSHD 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 195 VVIRLNSAPVEGYSEHVGNKTTIR------MTYPEGAPLSDLEYYSNDLFV--AVLFKSVDFNWLqamvKKETLPFWVRL 266
Cdd:cd23968   71 AVLRFNDAPTKGFEKDVGSKTTLRlinsqiLSKPEFNFLTDPLYRNVTLLVwdPSSYNVNLEKWY----KKPDFDFFPNY 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 267 FFWKQVaekIPLQPkhFRILNPVIIKEtAFDILQYSEPQSRFwgrdKNVPTIGVIAVVLATHLCDEVSLagFGYDLNQPR 346
Cdd:cd23968  147 IKYRRR---HPEEP--FYLIDPRFLWR-LWDILQEYTPEKIK----PNPPSSGFIGIVLMLHLCDWVDV--YEYVPSVRQ 214

                        250       260       270
                 ....*....|....*....|....*....|...
gi 109633046 347 TPL-HYFDSQCMAAMNFQTMHNVTTETKFLLKL 378
Cdd:cd23968  215 TDRcHYYDVEKDLACTLGAWHPLAAEKLLVRHL 247
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 150-385 1.19e-19

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 88.22  E-value: 1.19e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 150 TLLELLPEHdlpEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPegaplSD 229
Cdd:cd23970   52 NLRSLLPEV---SPFQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNP-----SI 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 230 LEYYSNDLFVavlfKSVDFNWLQAMVKKETLPFWVRLFFWKQVAEKiplqpkhFRILNPVIIKETAFDILQYSEPQ---- 305
Cdd:cd23970  124 LEKYYNNLLT----IQDRNNFFLSLKKLDGAILWIPAFFFHTSATV-------TRTLVDFFVEHRGQLKVQLAWPGnimq 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 306 --SRFWGRDKNVP---TIGVIAVVLATHLCDEVSLAGF---GYDLNQPRTPLHYFDSQ-CMAAMNFQTMHNVTTETKFLL 376
Cdd:cd23970  193 hvNRYWKTKHLSPkrlSTGILMYTLASAICEEIHLYGFwpfGFDPTGTPLPYHYYDKKgTKFTTKWQESHQLPAEFVLLY 272


                 ....*....
gi 109633046 377 KLVKEGVVK 385
Cdd:cd23970  273 KMHGAGVLK 281
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 135-385 3.65e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 87.11  E-value: 3.65e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 135 YDPPFGFRKFS-SKVQTLLELLPEHDLPEHLKA-----KTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYS 208
Cdd:cd23973   43 FNPPFGFMGLNyTLVKEVVELIPKPKEQQLLALsppggDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYE 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 209 EHVGNKTTIrmtYPEGAP--LSDLEYYSNDLF-----------VAVLFKSVDFNWLQAMVKKETLPfwvRLFFWKQVAEK 275
Cdd:cd23973  123 EDVGTRTSF---YVHTAHsiTSSLMILQKRGFknipqdkdikyILFPEGPRDYQWLEALLKNKTIP---SGAYYGRRPRS 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 276 I---PLQPKHFRILNPviiketafDILQYSepQSRFWgRDKNV---------PTIGVIAVVLATHLCDEVSLAGF---GY 340
Cdd:cd23973  197 YfsgDFTEDKYLVLHP--------DFLRYV--KNRFL-RSKTLkgkywaiyrPTTGAFLLLTALHLCDTVSAYGFiteDY 265

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 109633046 341 DlnqpRTPLHYFDSQcMAAMNFQTMHNVTTETKFLLKLVKEGVVK 385
Cdd:cd23973  266 R----KYPDHYYDKK-KTKLVFYINHDFRLEKKLWKRLHDEKIIK 305
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 149-385 7.91e-17

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 79.98  E-value: 7.91e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 149 QTLLELLPEhdlPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPegaplS 228
Cdd:cd23987   47 QNLYELLPR---TSPLKNKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNP-----S 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 229 DLEYYSNDLfvavlfksVDFNWLQAMVKK-ETLP---FWVRLFFWKQVAEKIplqpkhfRILNPVIIK-----ETAFDIL 299
Cdd:cd23987  119 VVQRAFEDL--------VNETWKEKFLQRlQSLNgsiLWIPAFMAKGGEERV-------EWVNDLILKhhinvRTAYPSL 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 300 QYSEPQSRFWGRDK---NVPTIGVIAVVLATHLCDEVSLAG---FGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETK 373
Cdd:cd23987  184 RLLHAVRGYWLTNKvhiKRPTTGLLMYTLATRFCNRIHLYGfwpFPRDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFK 263

                        250
                 ....*....|..
gi 109633046 374 FLLKLVKEGVVK 385
Cdd:cd23987  264 ALKNLHQQGALK 275
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 142-385 4.67e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 77.69  E-value: 4.67e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 142 RKFSSKVQTLLELLPEhdlPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVG--------N 213
Cdd:cd23988   40 RRTLNISQNLHSLLPE---VSPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGtksdfitmN 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 214 KTTIRMTYPEGAPLSDLEYYSNDLfvAVLFKSVdfnwlqamvkketlpFWVRLFFWKQvaekiplQPKHFRILNPVIIK- 292
Cdd:cd23988  117 PSVVQRAFGGFRNESDREKFVHRL--SMLNDSV---------------LWIPAFMVKG-------GEKHVEWVNALILKn 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 293 ----ETAFDILQYSEPQSRFWGRDK---NVPTIGVIAVVLATHLCDEVSLAG---FGYDLNQPRTPLHYFDSQCMAAMNF 362
Cdd:cd23988  173 klkvRTAYPSLRLIHAVRGYWLTNKvniKRPSTGLLMYTLATRFCDEIHLYGfwpFPKDANGNPVKYHYYDDLKYRYFSN 252

                        250       260
                 ....*....|....*....|...
gi 109633046 363 QTMHNVTTETKFLLKLVKEGVVK 385
Cdd:cd23988  253 AGPHRMPLEFKTLNVLHNRGALK 275
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 149-385 7.61e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 77.07  E-value: 7.61e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 149 QTLLELLPEHDlPehLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPls 228
Cdd:cd23969   47 QDLYQLLPEVS-P--LKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNPSVIP-- 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 229 dlEYYSNDLFVAVLFKSVDfnwlqamvkketlpfwvRLffwKQVAEKIPLQP--------KHFRILNPVIIKE-----TA 295
Cdd:cd23969  122 --HAYGDLVNATDKEKFVE-----------------RL---RQLGDSILWIPafvskggeEHVQWTNEIILKHklnvkTA 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 296 FDILQYSEPQSRFWGRDK---NVPTIGVIAVVLATHLCDEVSLAG---FGYDLNQPRTPLHYFDSQCMAAMNFQtmHNVT 369
Cdd:cd23969  180 YPPLRLNHAIRGYWLTTKfriKRPSTGLLMYTLATRFCDEIHLYGfypFSEDGNGRAVKYHYYDNRKYLTTARP--HKMP 257

                        250
                 ....*....|....*.
gi 109633046 370 TETKFLLKLVKEGVVK 385
Cdd:cd23969  258 EEFRALRSLHQRGALR 273
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 155-356 1.12e-15

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 76.28  E-value: 1.12e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 155 LPEHDLPEhlKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIR------MTYPEGAPLS 228
Cdd:cd23985   33 LPKKSLRE--EVGPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRlinsqlVTTEKHKFLK 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 229 DLEYYSNDLFVavlfksvdfnWLQAMVKKEtLPFWVR----LFF--WKQVAEKIPLQPkhFRILNPVIIKETaFDILQYS 302
Cdd:cd23985  111 DSLYNEGILIV----------WDPAPYHSD-IPEWYKnpdyNFFenYKTYRRLNPNQP--FYILHPQMQWEL-WDIIQEN 176

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 303 EPQSrfwgRDKNVPTIGVIAVVLATHLCDEVSLAGFgydL-NQPRTPL-----HYFDSQC 356
Cdd:cd23985  177 SPEE----IQPNPPSSGMLGIILMMTLCDQVDVYEF---LpSKRKTDVchyyqKFFDRAC 229
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 133-385 1.90e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 70.62  E-value: 1.90e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 133 SKYDPPFGFRKFSSK-VQTLLELLPEHD----LPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGY 207
Cdd:cd23972   41 SQRKVPYGWKGLSHQvVASTLSLLNDSAnaklFFPRDTPGKCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGF 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 208 SEHVGNKTTIR-----------MTY--------PEGaplSDLEYysndLFVAVLFKsvDFNWLQAMVKKETLPF------ 262
Cdd:cd23972  121 EEDVGTKTSFYgftvntmknslISYwnlgftrtPQG---QDLQY----IFIPSDIR--DYVMLRSAILGVPVPEgldkgd 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 263 -WVRLFFWKQVAEKiplqpkhFRILNPVIIKETAFDILQySEPQSRFWGrDKNVPTIGVIAVVLATHLCDEVSLAGFGYD 341
Cdd:cd23972  192 rPHKYFGPEASAKK-------FKLLHPDFISYLTDRFLK-SKLLNTHYG-HLYMPSTGALMLLTALHTCDQVSAYGFITS 262

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 109633046 342 lNQPRTPLHYFDSQcMAAMNFQTMHNVTTETKFLLKLVKEGVVK 385
Cdd:cd23972  263 -NYWKFSDHYYERK-KKPLVFYANHDMLLEAALWRRLHKAGILQ 304
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 170-387 2.12e-13

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 69.87  E-value: 2.12e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 170 RRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEgaPLSDLEYYSNDlfvAVLFKSVdfn 249
Cdd:cd23986   50 RSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQ--ILTNPNHHFID---SSLYKDV--- 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 250 wlqAMVKKETLPFWVRLFFW------------KQVAEKIPLQPkhFRILNPVIIKETaFDILQYSEPQSrfwgRDKNVPT 317
Cdd:cd23986  122 ---ILVAWDPAPYSANLHKWykkpdynlftpyVQYRKRNPNQP--FYILHPKFIWQL-WDIIQENTQEK----IQPNPPS 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 109633046 318 IGVIAVVLATHLCDEVSLAGFGYDLNQprTPL-HYFDSQCMAAMNFQTMHNVTTEtKFLLKLVKEGVVKDL 387
Cdd:cd23986  192 SGFIGILIMMSMCREVHVYEYIPSVRQ--TDLcHYHERYYDAACTLGAYHPLLYE-KLLIQRMNKGTEDDL 259
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 134-385 4.22e-13

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 68.82  E-value: 4.22e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 134 KYDppfGFRKFSSKV-QTLLELLPEhDLPehLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEgYSEHVG 212
Cdd:cd23971   34 HYE---GERKKTITVnEKLFSMLPK-ESP--FSNKPLKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVG 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 213 NKT----------TIRMTYPEGAPLS---DLEYYSNDLFvavlfksvdfnWLQAMVKKETLPFWVRLFFwkqVAEKIPLQ 279
Cdd:cd23971  107 SKTnlvtanpsilREKFHNLKKRRRPfveRMKVYGNALL-----------LLPAFSYTSNTEPSLRALY---TLEDFGSP 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 280 PKHFrILNPviiketafdilQYSEPQSRFWgRDKNVPTI----GVIAVVLATHLCDEVSLAGF---GYDLNQPRTPLHYF 352
Cdd:cd23971  173 QKVL-FFNP-----------EYLRNLSRYW-KSKGLKARrlstGLMLVSAALELCENVHLYGFwpfSTDLDGNPISHHYY 239

                        250       260       270
                 ....*....|....*....|....*....|...
gi 109633046 353 DsQCMAAMNFqtmHNVTTETKFLLKLVKEGVVK 385
Cdd:cd23971  240 D-NVLPKKGV---HAMPEEFLRYLKLHSQGVLR 268
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 169-220 3.47e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 65.34  E-value: 3.47e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 109633046 169 CRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMT 220
Cdd:cd23965    1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVV 52
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 169-385 2.01e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 64.39  E-value: 2.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 169 CRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMtypegaplsdleYYSNDLFVAVL-FKSVD 247
Cdd:cd23974   84 CIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYT------------FSTNTLMNSLRaYAGVG 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 248 FNWLQamVKKET----LPFWVRLFFWKQVA------EKIP-------------LQPKHFRILNPviiketafDILQYSep 304
Cdd:cd23974  152 FNGPP--QSKETryifLPDHDRDYLLVKAAlthtpiDRGRdkskrpskyfgkdVTAEKFKIYHP--------DFIRYL-- 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 305 QSRF-WG-------RDKNVPTIGVIAVVLATHLCDEVSLAGF---GYDLNQPrtplHYFDSQcMAAMNFQTMHNVTTETK 373
Cdd:cd23974  220 RNRFlWSpilntkqRDIYRPSTGAVMLLAALHTCDQVSAYGFmtpDYGKYSD----HYYDKT-YHKVVFYANHDLRLEMQ 294

                        250
                 ....*....|..
gi 109633046 374 FLLKLVKEGVVK 385
Cdd:cd23974  295 LWQKLHKAGLIK 306
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 162-353 1.92e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 60.65  E-value: 1.92e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 162 EHLKAKT-CRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTypegaPLSDLEYysndlfva 240
Cdd:cd23976    7 DHKPLKMhCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVI-----AHSSIQR-------- 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 241 VLFKSvdfNWLQAMVKKETLPFWVRLFFWKQVAEKipLQPKHFRILNPVIIKETAFDI-----LQYSEPQSRFWGRDKNV 315
Cdd:cd23976   74 ILRNR---NELLNVSQGTVFIFWGPSNYMRRDGKG--LVYNNLQLMNQILPKLKVYTItrhkmLQFDELFKRETGKDRKI 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 109633046 316 P----TIGVIAVVLATHLCDEVSLAG-----FGYDLNQPRTPLHYFD 353
Cdd:cd23976  149 SntwlSTGWFTMIIALELCDRINVYGmvppdFCRDPNHPSVPYHYYE 195
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 169-219 5.21e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 59.10  E-value: 5.21e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 109633046 169 CRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRM 219
Cdd:cd23978    1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRV 51
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 169-227 8.41e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 58.33  E-value: 8.41e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 109633046 169 CRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPL 227
Cdd:cd23977    1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVPL 59
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 169-227 2.27e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 51.09  E-value: 2.27e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 109633046 169 CRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPL 227
Cdd:cd23975    1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVPL 59
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 170-385 2.53e-07

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 51.68  E-value: 2.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 170 RRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEG-YSEHVGNKTT--------IRMTYPE----GAP-LSDLEYYSN 235
Cdd:cd23991   65 KQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNlvtanpsiISIKYAKlnerRKPfLETVSVYGD 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 236 DLFvavLFKSVDFNWLQAMVKK--ETLpfwvRLFFWKQvaekiplQPKHFrilNPVIIKETAfdilqysepqsRFWgRDK 313
Cdd:cd23991  145 AFL---LLPAFSYRSNTALSFKvyYTL----EDFKAKQ-------KVIFF---HPIYLKHLA-----------QFW-RSK 195

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 109633046 314 NVP----TIGVIAVVLATHLCDEVSLAGF-GYDLNQPRTPL--HYFDSQcMAAMNFqtmHNVTTETKFLLKLVKEGVVK 385
Cdd:cd23991  196 GVQvyrlSTGLMITSAALELCEEVKLYGFwPFSKNTEGKPIshHYYDNQ-LPKPGF---HSMPKEFYQLLQLHSKGILK 270
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 149-366 2.32e-06

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 48.68  E-value: 2.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 149 QTLLELLPEhDLPEHlkAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPV-EGYSEHVGNKTTIRMTYPEgapl 227
Cdd:cd23990   47 SEIFKMFPK-DMPYS--RSQFKKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPIsEKYVRDVGVKTDVVTINPS---- 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 228 sdleyysndlFVAVLFKSVDfnwlqamvkKETLPFWVRLffwkQVAEKIP-LQPKHFRILNPVIIKETAFDILQYSEPQ- 305
Cdd:cd23990  120 ----------IITERFHKLE---------KWRRPFYEVL----QVYENASvVLPAFYNTRNTDVSIRVKYVLDDFESQQa 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 306 ------------SRFWGRD---KNVPTIGVIAVVLATHLCDEVSLAGFG---------------YDLNQPRTPLHYFDSQ 355
Cdd:cd23990  177 vyyfhpqyllnvSRFWLRQgvrAKRISSGLMLVTAALELCEEVHLYGFWafpmnpsgifithhyYDNVKPRPGFHAMPSE 256

                        250
                 ....*....|.
gi 109633046 356 CmaaMNFQTMH 366
Cdd:cd23990  257 I---FNFLHMH 264
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 170-385 5.97e-05

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 44.44  E-value: 5.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 170 RRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPV-EGYSEHVGNKTTIRMTYPEgapLSDLEYYSNDLFVAVLFKSV-- 246
Cdd:cd23989   64 KKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPLsREYTDDVGTKTQLVTANPS---IIDKRFQNLLWSRKSFVESMkv 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633046 247 ---DFNWLQAM-VKKETLP-FWVrlffWKQVAEKIPLQPKHFRilNPVIIKETafdilqysepqSRFW-GRD---KNVPT 317
Cdd:cd23989  141 ygrSYIYMPAFsMKTGTDPsLRV----YYTLADVGANQTVLFA--NPNFLRNV-----------GKFWkSKGvhaKRLST 203

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 109633046 318 iGVIAVVLATHLCDEVSLAG---FGYDLNQPRTPLHYFDSQcmaaMNFQTMHNVTTETKFLLKLVKEGVVK 385
Cdd:cd23989  204 -GLFLVSAALGLCEEVTIYGfwpFSVDLDERTISHHYYDNV----LPDSGFHAMPEEFLQLWHLHKSGVLR 269
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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