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Conserved domains on  [gi|102467235|ref|NP_001035784|]
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inner centromere protein isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
INCENP_N pfam12178
Chromosome passenger complex (CPC) protein INCENP N terminal; This domain family is found in ...
 6-41 8.52e-17

Chromosome passenger complex (CPC) protein INCENP N terminal; This domain family is found in eukaryotes, and is approximately 40 amino acids in length. INCENP is a regulatory protein in the chromosome passenger complex. It is involved in regulation of the catalytic protein Aurora B. It performs this function in association with two other proteins - Survivin and Borealin. These proteins form a tight three-helical bundle. The N terminal domain is the domain involved in formation of this three helical bundle.


:

Pssm-ID: 463484 [Multi-domain]  Cd Length: 36  Bit Score: 74.66  E-value: 8.52e-17
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 102467235    6 PGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEA 41
Cdd:pfam12178   1 SGPASLLEVCDQKLSEFLCEIDNKHLVWLEEIEEEA 36
INCENP_ARK-bind pfam03941
Inner centromere protein, ARK binding region; This region of the inner centromere protein has ...
 827-881 2.81e-15

Inner centromere protein, ARK binding region; This region of the inner centromere protein has been found to be necessary and sufficient for binding to aurora-related kinase. This interaction has been implicated in the coordination of chromosome segregation with cell division in yeast.


:

Pssm-ID: 461100 [Multi-domain]  Cd Length: 53  Bit Score: 70.69  E-value: 2.81e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 102467235  827 NSDDSTDDEAHPRKPIPTWARGTPLSQAIIHQYyhPPNLLELFGTILPLDLEDIF 881
Cdd:pfam03941   1 NSDDEDDDEDEPRKPVPSWAQSPNLRQALIRQE--PIDPDEIFGPIPPLNLEEIF 53
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 535-784 2.27e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 68.04  E-value: 2.27e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235 535 VEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKfaQIDEKTEKAK 614
Cdd:COG1196  244 LEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERR--RELEERLEEL 321

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235 615 EERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERRE 694
Cdd:COG1196  322 EEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQ 401

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235 695 QERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQE 774
Cdd:COG1196  402 LEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAE 481

                        250
                 ....*....|
gi 102467235 775 EQEKKAKEAA 784
Cdd:COG1196  482 LLEELAEAAA 491
Caldesmon super family cl25547
Caldesmon;
406-615 1.15e-03

Caldesmon;


The actual alignment was detected with superfamily member pfam02029:

Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 42.55  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  406 TEIANSTPNpKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSY---------KQAVSELDEEQHLEDEELQPPR- 475
Cdd:pfam02029  94 ADEKESVAE-RKENNEEEENSSWEKEEKRDSRLGRYKEEETEIREKEYqenkwstevRQAEEEGEEEEDKSEEAEEVPTe 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  476 --SKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKER---------QRLEN 544
Cdd:pfam02029 173 nfAKEEVKDEKIKKEKKVKYESKVFLDQKRGHPEVKSQNGEEEVTKLKVTTKRRQGGLSQSQEREEeaevfleaeQKLEE 252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  545 LRRK------EEAEQLRRQK------VEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK---KKQIEQKFAQIDEK 609
Cdd:pfam02029 253 LRRRrqekesEEFEKLRQKQqeaeleLEELKKKREERRKLLEEEEQRRKQEEAERKLREEEEKrrmKEEIERRRAEAAEK 332


                  ....*.
gi 102467235  610 TEKAKE 615
Cdd:pfam02029 333 RQKLPE 338
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
141-287 1.64e-03

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK08691:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 709  Bit Score: 42.39  E-value: 1.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235 141 PSSPTPESPTMLTK---KPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMSTEPLPRTLSPTPASATAPTSQ----GIPT 213
Cdd:PRK08691 380 PSAQTAEKETAAKKpqpRPEAETAQTPVQTASAAAMPSEGKTAGPVSNQENNDVPPWEDAPDEAQTAAGTAQtsakSIQT 459

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 102467235 214 SDEESTPKK---SKARILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQVSPG-PRDSPAFPDSPWRERVLAPILP 287
Cdd:PRK08691 460 ASEAETPPEnqvSKNKAADNETDAPLSEVPSENPIQATPNDEAVETETFAHEAPAePFYGYGFPDNDCPPEDGAEIPP 537
 
Name Accession Description Interval E-value
INCENP_N pfam12178
Chromosome passenger complex (CPC) protein INCENP N terminal; This domain family is found in ...
 6-41 8.52e-17

Chromosome passenger complex (CPC) protein INCENP N terminal; This domain family is found in eukaryotes, and is approximately 40 amino acids in length. INCENP is a regulatory protein in the chromosome passenger complex. It is involved in regulation of the catalytic protein Aurora B. It performs this function in association with two other proteins - Survivin and Borealin. These proteins form a tight three-helical bundle. The N terminal domain is the domain involved in formation of this three helical bundle.


Pssm-ID: 463484 [Multi-domain]  Cd Length: 36  Bit Score: 74.66  E-value: 8.52e-17
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 102467235    6 PGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEA 41
Cdd:pfam12178   1 SGPASLLEVCDQKLSEFLCEIDNKHLVWLEEIEEEA 36
INCENP_ARK-bind pfam03941
Inner centromere protein, ARK binding region; This region of the inner centromere protein has ...
 827-881 2.81e-15

Inner centromere protein, ARK binding region; This region of the inner centromere protein has been found to be necessary and sufficient for binding to aurora-related kinase. This interaction has been implicated in the coordination of chromosome segregation with cell division in yeast.


Pssm-ID: 461100 [Multi-domain]  Cd Length: 53  Bit Score: 70.69  E-value: 2.81e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 102467235  827 NSDDSTDDEAHPRKPIPTWARGTPLSQAIIHQYyhPPNLLELFGTILPLDLEDIF 881
Cdd:pfam03941   1 NSDDEDDDEDEPRKPVPSWAQSPNLRQALIRQE--PIDPDEIFGPIPPLNLEEIF 53
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 535-784 2.27e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 68.04  E-value: 2.27e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235 535 VEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKfaQIDEKTEKAK 614
Cdd:COG1196  244 LEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERR--RELEERLEEL 321

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235 615 EERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERRE 694
Cdd:COG1196  322 EEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQ 401

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235 695 QERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQE 774
Cdd:COG1196  402 LEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAE 481

                        250
                 ....*....|
gi 102467235 775 EQEKKAKEAA 784
Cdd:COG1196  482 LLEELAEAAA 491
PTZ00121 PTZ00121
MAEBL; Provisional
 536-790 7.38e-11

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 66.70  E-value: 7.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  536 EKERQRLENLRRKEEAEQLRRQKVEEDKR-----RRLEEVK----LKREERLRKVLQARERVEQMKEEKKKQIEQKFAQI 606
Cdd:PTZ00121 1506 AEAKKKADEAKKAEEAKKADEAKKAEEAKkadeaKKAEEKKkadeLKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEE 1585

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  607 DEKTEKAK-EERLAEEKAKKKAAAKKMEEVEARR------KQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAA 679
Cdd:PTZ00121 1586 AKKAEEARiEEVMKLYEEEKKMKAEEAKKAEEAKikaeelKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAE 1665

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  680 EAKRlAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAErELQEREKALRLQKEQLQRELEEKK 759
Cdd:PTZ00121 1666 EAKK-AEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAE-ELKKAEEENKIKAEEAKKEAEEDK 1743

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 102467235  760 KKEEQQRLAE------RQLQEEQEKKAKEAAGASKAL 790
Cdd:PTZ00121 1744 KKAEEAKKDEeekkkiAHLKKEEEKKAEEIRKEKEAV 1780
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 536-793 1.01e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 49.35  E-value: 1.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  536 EKERQRLENLRRKEEAEQLRRQK--VEEDKRRRLEEVKLKRE---ERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKT 610
Cdd:pfam17380 347 ERELERIRQEERKRELERIRQEEiaMEISRMRELERLQMERQqknERVRQELEAARKVKILEEERQRKIQQQKVEMEQIR 426

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  611 EKAKEERlaeekakkkaaakkmeEVEARRKQEEEARRLRWLQQEEEERRHQelLQKKKEEEQERLRKAAEAKRLAEQREQ 690
Cdd:pfam17380 427 AEQEEAR----------------QREVRRLEEERAREMERVRLEEQERQQQ--VERLRQQEEERKRKKLELEKEKRDRKR 488

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  691 ERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQR---ELEEKKKKEEQQRL 767
Cdd:pfam17380 489 AEEQRRKILEKELEERKQAMIEEERKRKLLEKEMEERQKAIYEEERRREAEEERRKQQEMEERrriQEQMRKATEERSRL 568

                         250       260
                  ....*....|....*....|....*.
gi 102467235  768 AERQLQEEQEKKAKEAAGASKALNVT 793
Cdd:pfam17380 569 EAMEREREMMRQIVESEKARAEYEAT 594
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 533-784 1.73e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 45.43  E-value: 1.73e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235   533 SFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEqkfaQIDEKTEK 612
Cdd:TIGR02168  736 ARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALRE----ALDELRAE 811

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235   613 AKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLrwlqqeeeerrhqellqKKKEEEQERLRKAAEAKRLAEQREQER 692
Cdd:TIGR02168  812 LTLLNEEAANLRERLESLERRIAATERRLEDLEEQI-----------------EELSEDIESLAAEIEELEELIEELESE 874

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235   693 REQERREQERREQERREQERREQERQLAEQERRREQERLQAER-ELQEREKALRLQKEQLQRELeekkkKEEQQRLAERQ 771
Cdd:TIGR02168  875 LEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELeELREKLAQLELRLEGLEVRI-----DNLQERLSEEY 949

                          250
                   ....*....|...
gi 102467235   772 LQEEQEKKAKEAA 784
Cdd:TIGR02168  950 SLTLEEAEALENK 962
Caldesmon pfam02029
Caldesmon;
406-615 1.15e-03

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 42.55  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  406 TEIANSTPNpKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSY---------KQAVSELDEEQHLEDEELQPPR- 475
Cdd:pfam02029  94 ADEKESVAE-RKENNEEEENSSWEKEEKRDSRLGRYKEEETEIREKEYqenkwstevRQAEEEGEEEEDKSEEAEEVPTe 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  476 --SKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKER---------QRLEN 544
Cdd:pfam02029 173 nfAKEEVKDEKIKKEKKVKYESKVFLDQKRGHPEVKSQNGEEEVTKLKVTTKRRQGGLSQSQEREEeaevfleaeQKLEE 252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  545 LRRK------EEAEQLRRQK------VEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK---KKQIEQKFAQIDEK 609
Cdd:pfam02029 253 LRRRrqekesEEFEKLRQKQqeaeleLEELKKKREERRKLLEEEEQRRKQEEAERKLREEEEKrrmKEEIERRRAEAAEK 332


                  ....*.
gi 102467235  610 TEKAKE 615
Cdd:pfam02029 333 RQKLPE 338
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
 141-287 1.64e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 42.39  E-value: 1.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235 141 PSSPTPESPTMLTK---KPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMSTEPLPRTLSPTPASATAPTSQ----GIPT 213
Cdd:PRK08691 380 PSAQTAEKETAAKKpqpRPEAETAQTPVQTASAAAMPSEGKTAGPVSNQENNDVPPWEDAPDEAQTAAGTAQtsakSIQT 459

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 102467235 214 SDEESTPKK---SKARILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQVSPG-PRDSPAFPDSPWRERVLAPILP 287
Cdd:PRK08691 460 ASEAETPPEnqvSKNKAADNETDAPLSEVPSENPIQATPNDEAVETETFAHEAPAePFYGYGFPDNDCPPEDGAEIPP 537
 
Name Accession Description Interval E-value
INCENP_N pfam12178
Chromosome passenger complex (CPC) protein INCENP N terminal; This domain family is found in ...
 6-41 8.52e-17

Chromosome passenger complex (CPC) protein INCENP N terminal; This domain family is found in eukaryotes, and is approximately 40 amino acids in length. INCENP is a regulatory protein in the chromosome passenger complex. It is involved in regulation of the catalytic protein Aurora B. It performs this function in association with two other proteins - Survivin and Borealin. These proteins form a tight three-helical bundle. The N terminal domain is the domain involved in formation of this three helical bundle.


Pssm-ID: 463484 [Multi-domain]  Cd Length: 36  Bit Score: 74.66  E-value: 8.52e-17
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 102467235    6 PGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEA 41
Cdd:pfam12178   1 SGPASLLEVCDQKLSEFLCEIDNKHLVWLEEIEEEA 36
INCENP_ARK-bind pfam03941
Inner centromere protein, ARK binding region; This region of the inner centromere protein has ...
 827-881 2.81e-15

Inner centromere protein, ARK binding region; This region of the inner centromere protein has been found to be necessary and sufficient for binding to aurora-related kinase. This interaction has been implicated in the coordination of chromosome segregation with cell division in yeast.


Pssm-ID: 461100 [Multi-domain]  Cd Length: 53  Bit Score: 70.69  E-value: 2.81e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 102467235  827 NSDDSTDDEAHPRKPIPTWARGTPLSQAIIHQYyhPPNLLELFGTILPLDLEDIF 881
Cdd:pfam03941   1 NSDDEDDDEDEPRKPVPSWAQSPNLRQALIRQE--PIDPDEIFGPIPPLNLEEIF 53
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 535-784 2.27e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 68.04  E-value: 2.27e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235 535 VEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKfaQIDEKTEKAK 614
Cdd:COG1196  244 LEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERR--RELEERLEEL 321

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235 615 EERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERRE 694
Cdd:COG1196  322 EEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQ 401

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235 695 QERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQE 774
Cdd:COG1196  402 LEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAE 481

                        250
                 ....*....|
gi 102467235 775 EQEKKAKEAA 784
Cdd:COG1196  482 LLEELAEAAA 491
PTZ00121 PTZ00121
MAEBL; Provisional
 536-790 7.38e-11

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 66.70  E-value: 7.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  536 EKERQRLENLRRKEEAEQLRRQKVEEDKR-----RRLEEVK----LKREERLRKVLQARERVEQMKEEKKKQIEQKFAQI 606
Cdd:PTZ00121 1506 AEAKKKADEAKKAEEAKKADEAKKAEEAKkadeaKKAEEKKkadeLKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEE 1585

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  607 DEKTEKAK-EERLAEEKAKKKAAAKKMEEVEARR------KQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAA 679
Cdd:PTZ00121 1586 AKKAEEARiEEVMKLYEEEKKMKAEEAKKAEEAKikaeelKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAE 1665

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  680 EAKRlAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAErELQEREKALRLQKEQLQRELEEKK 759
Cdd:PTZ00121 1666 EAKK-AEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAE-ELKKAEEENKIKAEEAKKEAEEDK 1743

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 102467235  760 KKEEQQRLAE------RQLQEEQEKKAKEAAGASKAL 790
Cdd:PTZ00121 1744 KKAEEAKKDEeekkkiAHLKKEEEKKAEEIRKEKEAV 1780
PTZ00121 PTZ00121
MAEBL; Provisional
 537-788 2.00e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 65.16  E-value: 2.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  537 KERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMK---------EEKKKQIEQKFAQID 607
Cdd:PTZ00121 1287 EEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKkaaeaakaeAEAAADEAEAAEEKA 1366

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  608 EKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEeqerLRKAAEAKRLAEQ 687
Cdd:PTZ00121 1367 EAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEE----KKKADEAKKKAEE 1442

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  688 REQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQE-REKALRLQKEQLQRELEEKKKKEEQQR 766
Cdd:PTZ00121 1443 AKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEaKKKADEAKKAAEAKKKADEAKKAEEAK 1522

                         250       260
                  ....*....|....*....|..
gi 102467235  767 LAERQLQEEQEKKAKEAAGASK 788
Cdd:PTZ00121 1523 KADEAKKAEEAKKADEAKKAEE 1544
PTZ00121 PTZ00121
MAEBL; Provisional
 538-788 3.48e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 64.39  E-value: 3.48e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  538 ERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREErLRKVLQARERVEQMK--EEKKKQIEQKFAQIDEKTEKAKE 615
Cdd:PTZ00121 1573 EEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEE-AKKAEEAKIKAEELKkaEEEKKKVEQLKKKEAEEKKKAEE 1651

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  616 ERlaeekakKKAAAKKMEEVEARRKQEEEARRLRwlqqeeeerrhqellQKKKEEEQERlRKAAEAKRLAEQREQERREQ 695
Cdd:PTZ00121 1652 LK-------KAEEENKIKAAEEAKKAEEDKKKAE---------------EAKKAEEDEK-KAAEALKKEAEEAKKAEELK 1708

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  696 ERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEE 775
Cdd:PTZ00121 1709 KKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEE 1788

                         250
                  ....*....|...
gi 102467235  776 QEKKAKEAAGASK 788
Cdd:PTZ00121 1789 DEKRRMEVDKKIK 1801
PTZ00121 PTZ00121
MAEBL; Provisional
 536-781 1.35e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 62.47  E-value: 1.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  536 EKERQRLENLRRKEE----AEQLRRqKVEEDKRRRlEEVKlKREERLRKVLQARERVEQMK--EEKKKQIEQKfAQIDEK 609
Cdd:PTZ00121 1374 EEAKKKADAAKKKAEekkkADEAKK-KAEEDKKKA-DELK-KAAAAKKKADEAKKKAEEKKkaDEAKKKAEEA-KKADEA 1449

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  610 TEKAKEERlaeEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQ---ERLRKAAEAKRLAE 686
Cdd:PTZ00121 1450 KKKAEEAK---KAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKkkaDEAKKAEEAKKADE 1526

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  687 QREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQR 766
Cdd:PTZ00121 1527 AKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKK 1606

                         250
                  ....*....|....*
gi 102467235  767 LAERQLQEEQEKKAK 781
Cdd:PTZ00121 1607 MKAEEAKKAEEAKIK 1621
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 536-790 5.10e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 60.34  E-value: 5.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235 536 EKERQrLENLRRkeEAEQLRR-QKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAK 614
Cdd:COG1196  197 ELERQ-LEPLER--QAEKAERyRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELR 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235 615 ------EERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQR 688
Cdd:COG1196  274 leleelELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEEL 353

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235 689 EQERREQERREQERREQERREQERREQERQLAEQ---ERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQ 765
Cdd:COG1196  354 EEAEAELAEAEEALLEAEAELAEAEEELEELAEElleALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAEL 433

                        250       260
                 ....*....|....*....|....*
gi 102467235 766 RLAERQLQEEQEKKAKEAAGASKAL 790
Cdd:COG1196  434 EEEEEEEEEALEEAAEEEAELEEEE 458
PTZ00121 PTZ00121
MAEBL; Provisional
 534-683 7.14e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 60.15  E-value: 7.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  534 FVEKERQRLENLRRKEE----AEQLRRqkvEEDKRRRLEEVKLKREERLRKVLQARERVEQMK----EEKKKQIEQKfaQ 605
Cdd:PTZ00121 1601 YEEEKKMKAEEAKKAEEakikAEELKK---AEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKikaaEEAKKAEEDK--K 1675

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 102467235  606 IDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQelLQKKKEEEQERLRKAAEAKR 683
Cdd:PTZ00121 1676 KAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIK--AEEAKKEAEEDKKKAEEAKK 1751
PTZ00121 PTZ00121
MAEBL; Provisional
 537-781 8.74e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 59.77  E-value: 8.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  537 KERQRLENLRRKEE-----AEQLRRQKVEEDKRRRLEEVKLKRE-ERLRKVLQARERVEQMK-EEKKKQIEQKFAqidEK 609
Cdd:PTZ00121 1480 EEAKKADEAKKKAEeakkkADEAKKAAEAKKKADEAKKAEEAKKaDEAKKAEEAKKADEAKKaEEKKKADELKKA---EE 1556

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  610 TEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQ---ERLRKAAEAKRLAE 686
Cdd:PTZ00121 1557 LKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKikaEELKKAEEEKKKVE 1636

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  687 QREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQR 766
Cdd:PTZ00121 1637 QLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKK 1716

                         250
                  ....*....|....*
gi 102467235  767 LAERQLQEEQEKKAK 781
Cdd:PTZ00121 1717 KAEELKKAEEENKIK 1731
PTZ00121 PTZ00121
MAEBL; Provisional
 537-789 9.84e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 59.38  E-value: 9.84e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  537 KERQRLENLRRKEEAEQLRRQKVEEDKRRrLEEVKLKREERlRKVLQARERVEQMK---EEKKKQIEQ--KFAQIDEKTE 611
Cdd:PTZ00121 1275 EEARKADELKKAEEKKKADEAKKAEEKKK-ADEAKKKAEEA-KKADEAKKKAEEAKkkaDAAKKKAEEakKAAEAAKAEA 1352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  612 KAKEERLAEEKAKKKAaakkmeeveARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQ---ERLRKAA-------EA 681
Cdd:PTZ00121 1353 EAAADEAEAAEEKAEA---------AEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKkkaDELKKAAaakkkadEA 1423

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  682 KRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQK--EQLQRELEEKK 759
Cdd:PTZ00121 1424 KKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKkaEEAKKKADEAK 1503

                         250       260       270
                  ....*....|....*....|....*....|
gi 102467235  760 KKEEQQRLAERQLQEEQEKKAKEAAGASKA 789
Cdd:PTZ00121 1504 KAAEAKKKADEAKKAEEAKKADEAKKAEEA 1533
PTZ00121 PTZ00121
MAEBL; Provisional
 536-789 1.01e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 59.38  E-value: 1.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  536 EKERQRLENLRRK-EEAEQLRRQKVEEDKRRRLEEVKLKREERlRKVLQARERVEQMK--EEKKKQIEQKfAQIDEKTEK 612
Cdd:PTZ00121 1414 AAAKKKADEAKKKaEEKKKADEAKKKAEEAKKADEAKKKAEEA-KKAEEAKKKAEEAKkaDEAKKKAEEA-KKADEAKKK 1491

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  613 AKEERLAEEKAKKKAAAKKMEEvEARRKqeEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQER 692
Cdd:PTZ00121 1492 AEEAKKKADEAKKAAEAKKKAD-EAKKA--EEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEE 1568

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  693 REQERREQERREQERREQERREQERQLAEQERRREQERLQAE---RELQEREKALRLQKEQLQRELEEKKKKEEQQ--RL 767
Cdd:PTZ00121 1569 AKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEeakKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEekKK 1648

                         250       260
                  ....*....|....*....|..
gi 102467235  768 AERQLQEEQEKKAKEAAGASKA 789
Cdd:PTZ00121 1649 AEELKKAEEENKIKAAEEAKKA 1670
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 535-790 1.02e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 59.18  E-value: 1.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235 535 VEKERQRLENLRRKEEAEQLRRQKVEEDKRRrLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAK 614
Cdd:COG1196  269 LEELRLELEELELELEEAQAEEYELLAELAR-LEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELE 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235 615 EERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRwlqqeeeerrhqELLQKKKEEEQERLRKAAEAKRLAEQR--EQER 692
Cdd:COG1196  348 EAEEELEEAEAELAEAEEALLEAEAELAEAEEELE------------ELAEELLEALRAAAELAAQLEELEEAEeaLLER 415

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235 693 REQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQL 772
Cdd:COG1196  416 LERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLL 495

                        250
                 ....*....|....*...
gi 102467235 773 QEEQEKKAKEAAGASKAL 790
Cdd:COG1196  496 LLEAEADYEGFLEGVKAA 513
PTZ00121 PTZ00121
MAEBL; Provisional
 537-789 3.39e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 57.84  E-value: 3.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  537 KERQRLENLRRK-EEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMK--EEKKKQIEQKFAQIDEKTEKA 613
Cdd:PTZ00121 1454 EEAKKAEEAKKKaEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKkaDEAKKAEEAKKADEAKKAEEA 1533

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  614 KEERlaeekakkkaaakkmeevEARRKQE-EEARRLRWLQQEEEERRHQELLQKKKEEEQER--LRKAAEAKRLAEQREQ 690
Cdd:PTZ00121 1534 KKAD------------------EAKKAEEkKKADELKKAEELKKAEEKKKAEEAKKAEEDKNmaLRKAEEAKKAEEARIE 1595

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  691 ERREQERREQERREQERREQERREQERQLAEQERRREQERLQAER----------ELQEREKALRLQKEQLQRELEEKKK 760
Cdd:PTZ00121 1596 EVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKkeaeekkkaeELKKAEEENKIKAAEEAKKAEEDKK 1675

                         250       260
                  ....*....|....*....|....*....
gi 102467235  761 KEEQQRLAERQLQEEQEKKAKEAAGASKA 789
Cdd:PTZ00121 1676 KAEEAKKAEEDEKKAAEALKKEAEEAKKA 1704
PTZ00121 PTZ00121
MAEBL; Provisional
 537-789 3.03e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 54.76  E-value: 3.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  537 KERQRLENLRRK-EEAEQLRRQKVEEDKRRRLEEVKLKREERlRKVLQARERVEQMK--EEKKKQIEQKFAQIDEKTEKA 613
Cdd:PTZ00121 1428 EEKKKADEAKKKaEEAKKADEAKKKAEEAKKAEEAKKKAEEA-KKADEAKKKAEEAKkaDEAKKKAEEAKKKADEAKKAA 1506

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  614 KEERLAEEKAKKKAAAKKMEEVEARRKQE-EEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQER 692
Cdd:PTZ00121 1507 EAKKKADEAKKAEEAKKADEAKKAEEAKKaDEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEA 1586

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  693 REQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQL 772
Cdd:PTZ00121 1587 KKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEE 1666

                         250
                  ....*....|....*..
gi 102467235  773 QEEQEKKAKEAAGASKA 789
Cdd:PTZ00121 1667 AKKAEEDKKKAEEAKKA 1683
PTZ00121 PTZ00121
MAEBL; Provisional
 537-789 4.04e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 54.38  E-value: 4.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  537 KERQRLENLRRKEEAEQLRRQKVEEDKR-----RRLEEVK----LKREERLRKVLQAR--------ERVEQMKEEKKKQI 599
Cdd:PTZ00121 1149 EDAKRVEIARKAEDARKAEEARKAEDAKkaeaaRKAEEVRkaeeLRKAEDARKAEAARkaeeerkaEEARKAEDAKKAEA 1228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  600 EQKFAQIDEKTEKAK---EERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEeerrhqellQKKKEEE---QE 673
Cdd:PTZ00121 1229 VKKAEEAKKDAEEAKkaeEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAE---------EKKKADEakkAE 1299

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  674 RLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERElQEREKALRLQKEQLQR 753
Cdd:PTZ00121 1300 EKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAA-EEKAEAAEKKKEEAKK 1378

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 102467235  754 ELEEKKKKEEQQRLAE--RQLQEEQEKKAKEAAGASKA 789
Cdd:PTZ00121 1379 KADAAKKKAEEKKKADeaKKKAEEDKKKADELKKAAAA 1416
PTZ00121 PTZ00121
MAEBL; Provisional
 537-789 4.11e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 54.38  E-value: 4.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  537 KERQRLENLRRKEEAeqlrrQKVEEDKR----RRLEEVKlKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEK 612
Cdd:PTZ00121 1203 EAARKAEEERKAEEA-----RKAEDAKKaeavKKAEEAK-KDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEE 1276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  613 A-KEERLAEEKAKKKAAAKkmeevearrKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERL----RKAAEAKRLAEQ 687
Cdd:PTZ00121 1277 ArKADELKKAEEKKKADEA---------KKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKAdaakKKAEEAKKAAEA 1347

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  688 REQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRL 767
Cdd:PTZ00121 1348 AKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKA 1427

                         250       260
                  ....*....|....*....|..
gi 102467235  768 AERQLQEEQEKKAKEAAGASKA 789
Cdd:PTZ00121 1428 EEKKKADEAKKKAEEAKKADEA 1449
PTZ00121 PTZ00121
MAEBL; Provisional
 536-789 7.00e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 53.61  E-value: 7.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  536 EKERQRLENLRRKEEAEQLRRqkveEDKRRRLEEVKLKREERlRKVLQARERVEQMK----EEKKKQIEQKFAqiDEKTE 611
Cdd:PTZ00121 1353 EAAADEAEAAEEKAEAAEKKK----EEAKKKADAAKKKAEEK-KKADEAKKKAEEDKkkadELKKAAAAKKKA--DEAKK 1425

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  612 KAKEERlaeEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEqerlRKAAEAKRLAEQREQE 691
Cdd:PTZ00121 1426 KAEEKK---KADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEA----KKADEAKKKAEEAKKK 1498

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  692 RREQERREQERREQERREQERREQERQLAEQERRREQErlQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERq 771
Cdd:PTZ00121 1499 ADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKA--DEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEED- 1575

                         250
                  ....*....|....*...
gi 102467235  772 lQEEQEKKAKEAAGASKA 789
Cdd:PTZ00121 1576 -KNMALRKAEEAKKAEEA 1592
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 535-792 1.27e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 52.63  E-value: 1.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235 535 VEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAK 614
Cdd:COG1196  306 RLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELA 385

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235 615 EERLAEEKAKKKAAAKKMEevEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAeqreqerre 694
Cdd:COG1196  386 EELLEALRAAAELAAQLEE--LEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAEL--------- 454

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235 695 qerreqerreqerreqerreqerqlaeqerrreqerLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQE 774
Cdd:COG1196  455 ------------------------------------EEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLE 498

                        250
                 ....*....|....*...
gi 102467235 775 EQEKKAKEAAGASKALNV 792
Cdd:COG1196  499 AEADYEGFLEGVKAALLL 516
PTZ00121 PTZ00121
MAEBL; Provisional
 537-789 2.00e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 52.07  E-value: 2.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  537 KERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKRE----ERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEK 612
Cdd:PTZ00121 1215 EEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEirkfEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADE 1294

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  613 AK--EERLAEEKAKKKAAAKKMEEvEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEE----EQERLRKAAEAKRLAE 686
Cdd:PTZ00121 1295 AKkaEEKKKADEAKKKAEEAKKAD-EAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEaaadEAEAAEEKAEAAEKKK 1373

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  687 QREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAErELQEREKALRLQKEQLQRELEEKKKKEEQQR 766
Cdd:PTZ00121 1374 EEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKAD-EAKKKAEEKKKADEAKKKAEEAKKADEAKKK 1452

                         250       260
                  ....*....|....*....|...
gi 102467235  767 LAERQLQEEQEKKAKEAAGASKA 789
Cdd:PTZ00121 1453 AEEAKKAEEAKKKAEEAKKADEA 1475
PTZ00121 PTZ00121
MAEBL; Provisional
 536-784 5.90e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 50.52  E-value: 5.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  536 EKERQRLENLRRKEE---AEQLRR----QKVEEDKR----RRLEEVK----LKREERLRKVLQARERVEQMKEEKKKQIE 600
Cdd:PTZ00121 1118 EEAKKKAEDARKAEEarkAEDARKaeeaRKAEDAKRveiaRKAEDARkaeeARKAEDAKKAEAARKAEEVRKAEELRKAE 1197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  601 QkfAQIDEKTEKAKEERLAEEKAKKKAAAKKME--EVEARRKQEEEAR-----RLRWLQQEEEERRHQELLQKKKEEEQE 673
Cdd:PTZ00121 1198 D--ARKAEAARKAEEERKAEEARKAEDAKKAEAvkKAEEAKKDAEEAKkaeeeRNNEEIRKFEEARMAHFARRQAAIKAE 1275

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  674 RLRKAAEAKRlAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQR 753
Cdd:PTZ00121 1276 EARKADELKK-AEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEA 1354

                         250       260       270
                  ....*....|....*....|....*....|.
gi 102467235  754 ELEEKKKKEEQQRLAErqLQEEQEKKAKEAA 784
Cdd:PTZ00121 1355 AADEAEAAEEKAEAAE--KKKEEAKKKADAA 1383
PRK12704 PRK12704
phosphodiesterase; Provisional
 533-615 6.89e-06

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 49.78  E-value: 6.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235 533 SFVEKERQRLENLRR------KEEAEQLRRQkVEEDKRRRLEEVK------LKREERLRKVLQARERVEQMKEEKKKQIE 600
Cdd:PRK12704  42 RILEEAKKEAEAIKKealleaKEEIHKLRNE-FEKELRERRNELQklekrlLQKEENLDRKLELLEKREEELEKKEKELE 120

                         90
                 ....*....|....*
gi 102467235 601 QKFAQIDEKTEKAKE 615
Cdd:PRK12704 121 QKQQELEKKEEELEE 135
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 536-793 1.01e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 49.35  E-value: 1.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  536 EKERQRLENLRRKEEAEQLRRQK--VEEDKRRRLEEVKLKRE---ERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKT 610
Cdd:pfam17380 347 ERELERIRQEERKRELERIRQEEiaMEISRMRELERLQMERQqknERVRQELEAARKVKILEEERQRKIQQQKVEMEQIR 426

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  611 EKAKEERlaeekakkkaaakkmeEVEARRKQEEEARRLRWLQQEEEERRHQelLQKKKEEEQERLRKAAEAKRLAEQREQ 690
Cdd:pfam17380 427 AEQEEAR----------------QREVRRLEEERAREMERVRLEEQERQQQ--VERLRQQEEERKRKKLELEKEKRDRKR 488

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  691 ERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQR---ELEEKKKKEEQQRL 767
Cdd:pfam17380 489 AEEQRRKILEKELEERKQAMIEEERKRKLLEKEMEERQKAIYEEERRREAEEERRKQQEMEERrriQEQMRKATEERSRL 568

                         250       260
                  ....*....|....*....|....*.
gi 102467235  768 AERQLQEEQEKKAKEAAGASKALNVT 793
Cdd:pfam17380 569 EAMEREREMMRQIVESEKARAEYEAT 594
PTZ00121 PTZ00121
MAEBL; Provisional
 536-789 1.32e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 49.37  E-value: 1.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  536 EKERQRlENLRRKEEAEQL----RRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAqidEKTE 611
Cdd:PTZ00121 1246 EEERNN-EEIRKFEEARMAhfarRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKA---DEAK 1321

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  612 KAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRlrwlqQEEEERRHQELLQKKKEEEQerlRKAAEAKRLAEQREQE 691
Cdd:PTZ00121 1322 KKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAAD-----EAEAAEEKAEAAEKKKEEAK---KKADAAKKKAEEKKKA 1393

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  692 RREQERREQERREQER-REQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQREleekKKKEEQQRLAER 770
Cdd:PTZ00121 1394 DEAKKKAEEDKKKADElKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAK----KAEEAKKKAEEA 1469

                         250
                  ....*....|....*....
gi 102467235  771 QLQEEQEKKAKEAAGASKA 789
Cdd:PTZ00121 1470 KKADEAKKKAEEAKKADEA 1488
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 536-790 2.17e-05

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 48.43  E-value: 2.17e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235   536 EKERQRLEnlrrkEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKqiEQKFAQIDEKTEKAKE 615
Cdd:pfam02463  152 PERRLEIE-----EEAAGSRLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKK--ALEYYQLKEKLELEEE 224

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235   616 ERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQ 695
Cdd:pfam02463  225 YLLYLDYLKLNEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLK 304

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235   696 ERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEE 775
Cdd:pfam02463  305 LERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESE 384

                          250
                   ....*....|....*
gi 102467235   776 QEKKAKEAAGASKAL 790
Cdd:pfam02463  385 RLSSAAKLKEEELEL 399
PTZ00121 PTZ00121
MAEBL; Provisional
 521-789 2.38e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 48.60  E-value: 2.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  521 KRNTPLRMDPKCSFVEKERQR---LENLRRKEEAEQLRRQKVEEDkrRRLEEVKlKREERLRKVLQARERVEQMK-EEKK 596
Cdd:PTZ00121 1070 EGLKPSYKDFDFDAKEDNRADeatEEAFGKAEEAKKTETGKAEEA--RKAEEAK-KKAEDARKAEEARKAEDARKaEEAR 1146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  597 KQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQE----EEARRLRWLQQEEEERRHQELLQKKKEEEQ 672
Cdd:PTZ00121 1147 KAEDAKRVEIARKAEDARKAEEARKAEDAKKAEAARKAEEVRKAEElrkaEDARKAEAARKAEEERKAEEARKAEDAKKA 1226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  673 ERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAE-------RELQEREKALR 745
Cdd:PTZ00121 1227 EAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEkkkadeaKKAEEKKKADE 1306

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 102467235  746 LQK--------EQLQRELEEKKKKEEQ-QRLAERQLQEEQEKKAKEAAGASKA 789
Cdd:PTZ00121 1307 AKKkaeeakkaDEAKKKAEEAKKKADAaKKKAEEAKKAAEAAKAEAEAAADEA 1359
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 546-685 3.89e-05

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 47.11  E-value: 3.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235 546 RRKEEaeqlRRQKVEEDKRRRLEEVKLKREERLRKVLQARERveqmKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKK 625
Cdd:PRK09510  75 KRAEE----QRKKKEQQQAEELQQKQAAEQERLKQLEKERLA----AQEQKKQAEEAAKQAALKQKQAEEAAAKAAAAAK 146

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 102467235 626 KAAAKKMEEVEARRKQ-EEEARRLrwlqQEEEERRHQELLQKKKEEEQERLRKAAEAKRLA 685
Cdd:PRK09510 147 AKAEAEAKRAAAAAKKaAAEAKKK----AEAEAAKKAAAEAKKKAEAEAAAKAAAEAKKKA 203
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 536-784 4.00e-05

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 47.66  E-value: 4.00e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235   536 EKERQRLENLRRKEEAEQLRR-----QKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKT 610
Cdd:pfam02463  206 AKKALEYYQLKEKLELEEEYLlyldyLKLNEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQE 285

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235   611 EKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEqreq 690
Cdd:pfam02463  286 EELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEEL---- 361

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235   691 eRREQERREQERREQERREQERREQERQLAEQERRREQERLQAERE----LQEREKALRLQKEQLQRELEEKKKKEEQQR 766
Cdd:pfam02463  362 -EKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEaqllLELARQLEDLLKEEKKEELEILEEEEESIE 440

                          250
                   ....*....|....*...
gi 102467235   767 LAERQLQEEQEKKAKEAA 784
Cdd:pfam02463  441 LKQGKLTEEKEELEKQEL 458
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 536-782 6.60e-05

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 46.89  E-value: 6.60e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235   536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLeevKLKREER-----LRKVLQARERVEQMKEEKKKQIEQKFAQIDEKT 610
Cdd:pfam02463  169 RKKKEALKKLIEETENLAELIIDLEELKLQEL---KLKEQAKkaleyYQLKEKLELEEEYLLYLDYLKLNEERIDLLQEL 245

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235   611 EKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRlrwLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQ 690
Cdd:pfam02463  246 LRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKK---LQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKE 322

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235   691 ERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAER 770
Cdd:pfam02463  323 KKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSE 402

                          250
                   ....*....|..
gi 102467235   771 QLQEEQEKKAKE 782
Cdd:pfam02463  403 EEKEAQLLLELA 414
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 529-687 1.06e-04

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 45.71  E-value: 1.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  529 DPKCSFVEKERQRLENLRR-KEEAEQLRRQKVEEDKRRRLEEVKLKREERlrkvlqarERVEQMKEEKKKQIEQKFAQID 607
Cdd:pfam15709 319 DPSKALLEKREQEKASRDRlRAERAEMRRLEVERKRREQEEQRRLQQEQL--------ERAEKMREELELEQQRRFEEIR 390

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  608 EKTEKAKEERLAEEKAKKKAAAKKMEEVE-ARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAE 686
Cdd:pfam15709 391 LRKQRLEEERQRQEEEERKQRLQLQAAQErARQQQEEFRRKLQELQRKKQQEEAERAEAEKQRQKELEMQLAEEQKRLME 470


                  .
gi 102467235  687 Q 687
Cdd:pfam15709 471 M 471
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 533-781 1.35e-04

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 45.73  E-value: 1.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235   533 SFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEK--- 609
Cdd:pfam02463  747 EEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLieq 826

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235   610 TEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQRE 689
Cdd:pfam02463  827 EEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEES 906

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235   690 QERREQERREQERREQERREQERREQERQLAEQERRREQERLQAE---RELQEREKALRLQKEQLQRE-----LEEKKKK 761
Cdd:pfam02463  907 QKLNLLEEKENEIEERIKEEAEILLKYEEEPEELLLEEADEKEKEennKEEEEERNKRLLLAKEELGKvnlmaIEEFEEK 986

                          250       260
                   ....*....|....*....|
gi 102467235   762 EEQQRLAERQLQEEQEKKAK 781
Cdd:pfam02463  987 EERYNKDELEKERLEEEKKK 1006
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 533-784 1.73e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 45.43  E-value: 1.73e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235   533 SFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEqkfaQIDEKTEK 612
Cdd:TIGR02168  736 ARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALRE----ALDELRAE 811

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235   613 AKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLrwlqqeeeerrhqellqKKKEEEQERLRKAAEAKRLAEQREQER 692
Cdd:TIGR02168  812 LTLLNEEAANLRERLESLERRIAATERRLEDLEEQI-----------------EELSEDIESLAAEIEELEELIEELESE 874

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235   693 REQERREQERREQERREQERREQERQLAEQERRREQERLQAER-ELQEREKALRLQKEQLQRELeekkkKEEQQRLAERQ 771
Cdd:TIGR02168  875 LEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELeELREKLAQLELRLEGLEVRI-----DNLQERLSEEY 949

                          250
                   ....*....|...
gi 102467235   772 LQEEQEKKAKEAA 784
Cdd:TIGR02168  950 SLTLEEAEALENK 962
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 535-682 3.22e-04

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 44.07  E-value: 3.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  535 VEKERQRLENLRRKEEAEQ--LRRQKVEEDKRRRLEEVKLKR-EERLRKVLQARErveqmKEEKKKQIEQKFAQIDEKTE 611
Cdd:TIGR02794  52 ANRIQQQKKPAAKKEQERQkkLEQQAEEAEKQRAAEQARQKElEQRAAAEKAAKQ-----AEQAAKQAEEKQKQAEEAKA 126

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 102467235  612 KAKEERLAEEKAKKKAAAKKmeevEARRKQEEEARrlrwlqqeeeerrHQELLQKKKEEEQERLRKAAEAK 682
Cdd:TIGR02794 127 KQAAEAKAKAEAEAERKAKE----EAAKQAEEEAK-------------AKAAAEAKKKAEEAKKKAEAEAK 180
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 535-791 5.18e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 43.89  E-value: 5.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235   535 VEKERQRLENLRRKEEAEQLRRQKVEEDKRR---RLEEVKLKREERLRKVLQAR----------ERVEQMKE---EKKKQ 598
Cdd:TIGR02168  234 LEELREELEELQEELKEAEEELEELTAELQEleeKLEELRLEVSELEEEIEELQkelyalaneiSRLEQQKQilrERLAN 313

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235   599 IEQKFAQID---EKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERL 675
Cdd:TIGR02168  314 LERQLEELEaqlEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLEL 393

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235   676 RKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERL----QAERELQEREKALRLQKEQL 751
Cdd:TIGR02168  394 QIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELeelqEELERLEEALEELREELEEA 473

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 102467235   752 QRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALN 791
Cdd:TIGR02168  474 EQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLK 513
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 540-671 7.57e-04

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 43.28  E-value: 7.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235 540 QRLENLRRkeEAEQlrrqkveedKRRRLEEvKLKREERLRKVLQAR-ERVEQMKEEKKKQIEQKFAQIdekTEKAKEERL 618
Cdd:PRK00409 523 ASLEELER--ELEQ---------KAEEAEA-LLKEAEKLKEELEEKkEKLQEEEDKLLEEAEKEAQQA---IKEAKKEAD 587

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 102467235 619 AEEKAKKKAAAKKMEEVeaRRKQEEEARRLrwLQQEEEERRHQELLQKKKEEE 671
Cdd:PRK00409 588 EIIKELRQLQKGGYASV--KAHELIEARKR--LNKANEKKEKKKKKQKEKQEE 636
RNase_Y_N pfam12072
RNase Y N-terminal region;
535-615 1.04e-03

RNase Y N-terminal region;


Pssm-ID: 463456 [Multi-domain]  Cd Length: 201  Bit Score: 41.41  E-value: 1.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  535 VEKERQRLENLRR------KEEAEQLRRQKVEEDKRRR-----LEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKF 603
Cdd:pfam12072  40 IEEAKKEAETKKKealleaKEEIHKLRAEAERELKERRnelqrQERRLLQKEETLDRKDESLEKKEESLEKKEKELEAQQ 119

                          90
                  ....*....|..
gi 102467235  604 AQIDEKTEKAKE 615
Cdd:pfam12072 120 QQLEEKEEELEE 131
Caldesmon pfam02029
Caldesmon;
406-615 1.15e-03

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 42.55  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  406 TEIANSTPNpKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSY---------KQAVSELDEEQHLEDEELQPPR- 475
Cdd:pfam02029  94 ADEKESVAE-RKENNEEEENSSWEKEEKRDSRLGRYKEEETEIREKEYqenkwstevRQAEEEGEEEEDKSEEAEEVPTe 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  476 --SKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKER---------QRLEN 544
Cdd:pfam02029 173 nfAKEEVKDEKIKKEKKVKYESKVFLDQKRGHPEVKSQNGEEEVTKLKVTTKRRQGGLSQSQEREEeaevfleaeQKLEE 252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  545 LRRK------EEAEQLRRQK------VEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK---KKQIEQKFAQIDEK 609
Cdd:pfam02029 253 LRRRrqekesEEFEKLRQKQqeaeleLEELKKKREERRKLLEEEEQRRKQEEAERKLREEEEKrrmKEEIERRRAEAAEK 332


                  ....*.
gi 102467235  610 TEKAKE 615
Cdd:pfam02029 333 RQKLPE 338
PRK05035 PRK05035
electron transport complex protein RnfC; Provisional
 539-789 1.42e-03

electron transport complex protein RnfC; Provisional


Pssm-ID: 235334 [Multi-domain]  Cd Length: 695  Bit Score: 42.24  E-value: 1.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235 539 RQRLENLRRKEEAEQ---LRRQKVEEDKRRRLEEVKLKREERLRK----VLQARERVEQMKEEKKKQIEQKFAQIDEKTE 611
Cdd:PRK05035 439 RAIEQEKKKAEEAKArfeARQARLEREKAAREARHKKAAEARAAKdkdaVAAALARVKAKKAAATQPIVIKAGARPDNSA 518

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235 612 KAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRwlqqeEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQE 691
Cdd:PRK05035 519 VIAAREARKAQARARQAEKQAAAAADPKKAAVAAAIAR-----AKAKKAAQQAANAEAEEEVDPKKAAVAAAIARAKAKK 593

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235 692 RREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKalrlqKEQLQRELEEKK-KKEEQQRLAER 770
Cdd:PRK05035 594 AAQQAASAEPEEQVAEVDPKKAAVAAAIARAKAKKAEQQANAEPEEPVDPR-----KAAVAAAIARAKaRKAAQQQANAE 668

                        250
                 ....*....|....*....
gi 102467235 771 QLQEEQEKKAKEAAGASKA 789
Cdd:PRK05035 669 PEEAEDPKKAAVAAAIARA 687
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
 141-287 1.64e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 42.39  E-value: 1.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235 141 PSSPTPESPTMLTK---KPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMSTEPLPRTLSPTPASATAPTSQ----GIPT 213
Cdd:PRK08691 380 PSAQTAEKETAAKKpqpRPEAETAQTPVQTASAAAMPSEGKTAGPVSNQENNDVPPWEDAPDEAQTAAGTAQtsakSIQT 459

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 102467235 214 SDEESTPKK---SKARILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQVSPG-PRDSPAFPDSPWRERVLAPILP 287
Cdd:PRK08691 460 ASEAETPPEnqvSKNKAADNETDAPLSEVPSENPIQATPNDEAVETETFAHEAPAePFYGYGFPDNDCPPEDGAEIPP 537
ERM_helical pfam20492
Ezrin/radixin/moesin, alpha-helical domain; The ERM family consists of three closely-related ...
 541-649 2.04e-03

Ezrin/radixin/moesin, alpha-helical domain; The ERM family consists of three closely-related proteins, ezrin, radixin and moesin. Ezrin was first identified as a constituent of microvilli, radixin as a barbed, end-capping actin-modulating protein from isolated junctional fractions, and moesin as a heparin binding protein. A tumour suppressor molecule responsible for neurofibromatosis type 2 (NF2) is highly similar to ERM proteins and has been designated merlin (moesin-ezrin-radixin-like protein). ERM molecules contain 3 domains, an N-terminal globular domain, an extended alpha-helical domain and a charged C-terminal domain (pfam00769). Ezrin, radixin and merlin also contain a polyproline linker region between the helical and C-terminal domains. The N-terminal domain is highly conserved and is also found in merlin, band 4.1 proteins and members of the band 4.1 superfamily, designated the FERM domain. ERM proteins crosslink actin filaments with plasma membranes. They co-localize with CD44 at actin filament plasma membrane interaction sites, associating with CD44 via their N-terminal domains and with actin filaments via their C-terminal domains. This is the alpha-helical domain, which is involved in intramolecular masking of protein-protein interaction sites, regulating the activity of this proteins.


Pssm-ID: 466641 [Multi-domain]  Cd Length: 120  Bit Score: 39.13  E-value: 2.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  541 RLENLRRKEEAEQLRRQKVEEDKR-----RRLEEVKLKREERLRKVLQARERVEQmkeeKKKQIEQKFAQIDEKTEKAKE 615
Cdd:pfam20492   1 REEAEREKQELEERLKQYEEETKKaqeelEESEETAEELEEERRQAEEEAERLEQ----KRQEAEEEKERLEESAEMEAE 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 102467235  616 ERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLR 649
Cdd:pfam20492  77 EKEQLEAELAEAQEEIARLEEEVERKEEEARRLQ 110
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 535-683 2.79e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 41.65  E-value: 2.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  535 VEKERQRlENLRRKEEAEQLRRQKV-EEDKRRRLEEVKLK-----------REERLRKVLQAR----ERVEQMKEEKKKQ 598
Cdd:pfam17380 383 LQMERQQ-KNERVRQELEAARKVKIlEEERQRKIQQQKVEmeqiraeqeeaRQREVRRLEEERaremERVRLEEQERQQQ 461

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  599 IE----QKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERrhqellQKKKEEEQER 674
Cdd:pfam17380 462 VErlrqQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEERKRKLLEKEMEER------QKAIYEEERR 535


                  ....*....
gi 102467235  675 lRKAAEAKR 683
Cdd:pfam17380 536 -REAEEERR 543
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 538-790 3.95e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 40.29  E-value: 3.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  538 ERQRLENLRRKEEAEQLR---RQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAK 614
Cdd:pfam13868  79 EEQIEEREQKRQEEYEEKlqeREQMDEIVERIQEEDQAEAEEKLEKQRQLREEIDEFNEEQAEWKELEKEEEREEDERIL 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  615 EERLAEEKAKKKAAAKKMeevEARRKQEEEARRLRWLQQEEEERRHQ--ELLQKKKEEEQERLRKAAEAKRLAEQREQER 692
Cdd:pfam13868 159 EYLKEKAEREEEREAERE---EIEEEKEREIARLRAQQEKAQDEKAErdELRAKLYQEEQERKERQKEREEAEKKARQRQ 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  693 REQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREkalRLQKEQLQRELEEKKKKEEQQRLAERQL 772
Cdd:pfam13868 236 ELQQAREEQIELKERRLAEEAEREEEEFERMLRKQAEDEEIEQEEAEKR---RMKRLEHRRELEKQIEEREEQRAAEREE 312

                         250
                  ....*....|....*...
gi 102467235  773 QEEQEKKAKEAAGASKAL 790
Cdd:pfam13868 313 ELEEGERLREEEAERRER 330
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 536-649 4.25e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.08  E-value: 4.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235 536 EKERQRLENLRRKEEAEQLRRQKVEEdkRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKE 615
Cdd:COG1196  666 SRRELLAALLEAEAELEELAERLAEE--ELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLE 743

                         90       100       110
                 ....*....|....*....|....*....|....
gi 102467235 616 ERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLR 649
Cdd:COG1196  744 EEELLEEEALEELPEPPDLEELERELERLEREIE 777
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 142-513 4.65e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 40.67  E-value: 4.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  142 SSPTPE------SPTMLTKKPEDNHTqcqlvpvveigisERQNAEQHVTQLMSTEPLPRTLSPTPAsATAPTSQGIPTSD 215
Cdd:pfam05109 474 TSPTPAgttsgaSPVTPSPSPRDNGT-------------ESKAPDMTSPTSAVTTPTPNATSPTPA-VTTPTPNATSPTL 539

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  216 EESTPKKSKARILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQVSPGPrDSPAFPDSPWRERVLAPILPDNFSTPTG 295
Cdd:pfam05109 540 GKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNA-TSPTVGETSPQANTTNHTLGGTSSTPVV 618

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  296 SrtdsQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVrraSRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQ 375
Cdd:pfam05109 619 T----SPPKNATSAVTTGQHNITSSSTSSMSLRPSSI---SETLSPSTSDNSTSHMPLLTSAHPTGGENITQVTPASTST 691

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  376 KEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQ 455
Cdd:pfam05109 692 HHVSTSSPAPRPGTTSQASGPGNSSTSTKPGEVNVTKGTPPKNATSPQAPSGQKTAVPTVTSTGGKANSTTGGKHTTGHG 771

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 102467235  456 AVSELDEEQHLEDEElQPPRSK---TPSSPCPASKVVRPLRTFLH---TVQRNQMLMTPTSAPR 513
Cdd:pfam05109 772 ARTSTEPTTDYGGDS-TTPRTRynaTTYLPPSTSSKLRPRWTFTSppvTTAQATVPVPPTSQPR 834
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 536-616 5.42e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.82  E-value: 5.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235   536 EKERQRLENLRRKEEAEQLRR----------QKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK---------- 595
Cdd:TIGR02169  332 DKLLAEIEELEREIEEERKRRdklteeyaelKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREInelkreldrl 411

                           90       100
                   ....*....|....*....|....
gi 102467235   596 ---KKQIEQKFAQIDEKTEKAKEE 616
Cdd:TIGR02169  412 qeeLQRLSEELADLNAAIAGIEAK 435
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 566-682 6.20e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 40.20  E-value: 6.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235 566 RLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEErlaeekakkkaaaKKMEEVEARRKQEEEA 645
Cdd:PRK00409 524 SLEELERELEQKAEEAEALLKEAEKLKEELEEKKEKLQEEEDKLLEEAEKE-------------AQQAIKEAKKEADEII 590

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 102467235 646 RRLRWLQQEEEERRHQELLQkkkeEEQERLRKAAEAK 682
Cdd:PRK00409 591 KELRQLQKGGYASVKAHELI----EARKRLNKANEKK 623
hsdR PRK11448
type I restriction enzyme EcoKI subunit R; Provisional
 534-617 6.69e-03

type I restriction enzyme EcoKI subunit R; Provisional


Pssm-ID: 236912 [Multi-domain]  Cd Length: 1123  Bit Score: 40.32  E-value: 6.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  534 FVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLqarERVEQMKEEKKKQIEQKFAQIDEKTEKA 613
Cdd:PRK11448  134 FVPPEDPENLLHALQQEVLTLKQQLELQAREKAQSQALAEAQQQELVAL---EGLAAELEEKQQELEAQLEQLQEKAAET 210


                  ....
gi 102467235  614 KEER 617
Cdd:PRK11448  211 SQER 214
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
525-615 7.02e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 40.41  E-value: 7.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235 525 PLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEdKRRRLEEVKlKREERLRKVLQARERVEQMKEEKKKQIEQKFA 604
Cdd:PRK02224 460 PVEGSPHVETIEEDRERVEELEAELEDLEEEVEEVEE-RLERAEDLV-EAEDRIERLEERREDLEELIAERRETIEEKRE 537

                         90
                 ....*....|.
gi 102467235 605 QIDEKTEKAKE 615
Cdd:PRK02224 538 RAEELRERAAE 548
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 538-674 8.28e-03

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 38.10  E-value: 8.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 102467235  538 ERQRLENLRRKEEaEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEER 617
Cdd:pfam05672  18 EKRRQAREQRERE-EQERLEKEEEERLRKEELRRRAEEERARREEEARRLEEERRREEEERQRKAEEEAEEREQREQEEQ 96

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 102467235  618 LAEEKAKKkaaakkmeevEARRKQEEEARRLRwlqqeeeeRRHQELLQKKKEEEQER 674
Cdd:pfam05672  97 ERLQKQKE----------EAEAKAREEAERQR--------QEREKIMQQEEQERLER 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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