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Conserved domains on  [gi|98961138|ref|NP_001035743|]
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zinc finger protein ZXDC isoform 2 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11779830)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
284-443 9.86e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 9.86e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 98961138 284 SSHQRSHFEPER----PYKCdfPGCEKTFITVSALFSHNRA---HFREQELFSCSFPGCSKQYDKACRLKIHLRSHTGER 356
Cdd:COG5048 273 SSPNESDSSSEKgfslPIKS--KQCNISFSRSSPLTRHLRSvnhSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSIS 350

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 98961138 357 PFICDSDSCGWTFTSMS-----KLLRHRRKHDDDRRFTCPVEGCGKSFTRAEHLKGHSITHLGTKPFECPVEGCCARFSA 431
Cdd:COG5048 351 PAKEKLLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNR 430

                       170
                ....*....|..
gi 98961138 432 RSSLYIHSKKHV 443
Cdd:COG5048 431 HYNLIPHKKIHT 442
zf-C2H2_8 super family cl25789
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 240-317 6.40e-06

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


The actual alignment was detected with superfamily member pfam15909:

Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 45.10  E-value: 6.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 98961138   240 CPVGGCGKKFTTVYNLKAHMKGH------EQESLFKCEV--CAERFPTHAKLSSHQRSHFEPERPYKCDfpGCEKTFITV 311
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHcpptqsLEGKLFRCSAlsCTETFPSMQELVAHSKLHYKPNRYFKCE--NCLLRFRTH 79


                  ....*.
gi 98961138   312 SALFSH 317
Cdd:pfam15909  80 RSLFKH 85
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 204-260 5.00e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 5.00e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 98961138 204 GRRPFKCPLEGCGWAFTTSYKLKRHL---------------QSHD----KLRPFGCPVggCGKKFTTVYNLKAHMK 260
Cdd:COG5189 346 DGKPYKCPVEGCNKKYKNQNGLKYHMlhghqnqklhenpspEKMNifsaKDKPYRCEV--CDKRYKNLNGLKYHRK 419
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
284-443 9.86e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 9.86e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 98961138 284 SSHQRSHFEPER----PYKCdfPGCEKTFITVSALFSHNRA---HFREQELFSCSFPGCSKQYDKACRLKIHLRSHTGER 356
Cdd:COG5048 273 SSPNESDSSSEKgfslPIKS--KQCNISFSRSSPLTRHLRSvnhSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSIS 350

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 98961138 357 PFICDSDSCGWTFTSMS-----KLLRHRRKHDDDRRFTCPVEGCGKSFTRAEHLKGHSITHLGTKPFECPVEGCCARFSA 431
Cdd:COG5048 351 PAKEKLLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNR 430

                       170
                ....*....|..
gi 98961138 432 RSSLYIHSKKHV 443
Cdd:COG5048 431 HYNLIPHKKIHT 442
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 240-317 6.40e-06

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 45.10  E-value: 6.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 98961138   240 CPVGGCGKKFTTVYNLKAHMKGH------EQESLFKCEV--CAERFPTHAKLSSHQRSHFEPERPYKCDfpGCEKTFITV 311
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHcpptqsLEGKLFRCSAlsCTETFPSMQELVAHSKLHYKPNRYFKCE--NCLLRFRTH 79


                  ....*.
gi 98961138   312 SALFSH 317
Cdd:pfam15909  80 RSLFKH 85
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 204-260 5.00e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 5.00e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 98961138 204 GRRPFKCPLEGCGWAFTTSYKLKRHL---------------QSHD----KLRPFGCPVggCGKKFTTVYNLKAHMK 260
Cdd:COG5189 346 DGKPYKCPVEGCNKKYKNQNGLKYHMlhghqnqklhenpspEKMNifsaKDKPYRCEV--CDKRYKNLNGLKYHRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 236-291 1.09e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 1.09e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 98961138 236 RPFGCPVGGCGKKFTTVYNLKAHMK-GHEQESL------------------FKCEVCAERFPTHAKLSSHqRSHF 291
Cdd:COG5189 348 KPYKCPVEGCNKKYKNQNGLKYHMLhGHQNQKLhenpspekmnifsakdkpYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 208-232 7.72e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.72e-03
                          10        20
                  ....*....|....*....|....*
gi 98961138   208 FKCPleGCGWAFTTSYKLKRHLQSH 232
Cdd:pfam00096   1 YKCP--DCGKSFSRKSNLKRHLRTH 23
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 273-330 8.26e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 36.24  E-value: 8.26e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 98961138   273 CAERFPTHAKLSSHQRSHFEPERP-----YKCDFPGCEKTFITVSALFSHNRAHFREQELFSC 330
Cdd:pfam15909   7 CCLSFPSVRDLAQHLRTHCPPTQSlegklFRCSALSCTETFPSMQELVAHSKLHYKPNRYFKC 69
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
284-443 9.86e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 9.86e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 98961138 284 SSHQRSHFEPER----PYKCdfPGCEKTFITVSALFSHNRA---HFREQELFSCSFPGCSKQYDKACRLKIHLRSHTGER 356
Cdd:COG5048 273 SSPNESDSSSEKgfslPIKS--KQCNISFSRSSPLTRHLRSvnhSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSIS 350

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 98961138 357 PFICDSDSCGWTFTSMS-----KLLRHRRKHDDDRRFTCPVEGCGKSFTRAEHLKGHSITHLGTKPFECPVEGCCARFSA 431
Cdd:COG5048 351 PAKEKLLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNR 430

                       170
                ....*....|..
gi 98961138 432 RSSLYIHSKKHV 443
Cdd:COG5048 431 HYNLIPHKKIHT 442
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 240-317 6.40e-06

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 45.10  E-value: 6.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 98961138   240 CPVGGCGKKFTTVYNLKAHMKGH------EQESLFKCEV--CAERFPTHAKLSSHQRSHFEPERPYKCDfpGCEKTFITV 311
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHcpptqsLEGKLFRCSAlsCTETFPSMQELVAHSKLHYKPNRYFKCE--NCLLRFRTH 79


                  ....*.
gi 98961138   312 SALFSH 317
Cdd:pfam15909  80 RSLFKH 85
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
168-382 1.76e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.76e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 98961138 168 SGPSTPGYRCPEPQCALAFAKKHQLKVHL-LTHGGGQGRRPFKCPLEGCGWAFTTSYKLKRHLQSHDKLRPFGCPVGGCG 246
Cdd:COG5048 281 SSEKGFSLPIKSKQCNISFSRSSPLTRHLrSVNHSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSS 360

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 98961138 247 KKFttvyNLKAHMKGHEqeslfkcevcaerfpthaklSSHQRSHFEPERPYKCDFPGCEKTFITVSALFSHNRAHFREQE 326
Cdd:COG5048 361 SKF----SPLLNNEPPQ--------------------SLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRP 416

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 98961138 327 LfSCSFPGCSKQYDKACRLKIHLRSHTGERPFICdsdsCGWTFTSMSKLLRHRRKH 382
Cdd:COG5048 417 Y-NCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC----SILKSFRRDLDLSNHGKD 467
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 204-260 5.00e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 5.00e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 98961138 204 GRRPFKCPLEGCGWAFTTSYKLKRHL---------------QSHD----KLRPFGCPVggCGKKFTTVYNLKAHMK 260
Cdd:COG5189 346 DGKPYKCPVEGCNKKYKNQNGLKYHMlhghqnqklhenpspEKMNifsaKDKPYRCEV--CDKRYKNLNGLKYHRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 236-291 1.09e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 1.09e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 98961138 236 RPFGCPVGGCGKKFTTVYNLKAHMK-GHEQESL------------------FKCEVCAERFPTHAKLSSHqRSHF 291
Cdd:COG5189 348 KPYKCPVEGCNKKYKNQNGLKYHMLhGHQNQKLhenpspekmnifsakdkpYRCEVCDKRYKNLNGLKYH-RKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
391-442 3.56e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 3.56e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 98961138 391 PVEGCGKSFTRAEHLKGHSITHLGTKPFECPVEGCCARFSARSSLYIHSKKH 442
Cdd:COG5048  35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTH 86
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
283-471 1.39e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.39e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 98961138 283 LSSHQRSHFEPERPYKCDFPGCEKTFITVSALFSHNRAHFREqelfSCSFPGCSKQYDKACRLKIHLRSHTGERPF--IC 360
Cdd:COG5048 215 SSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSS----ASESPRSSLPTASSQSSSPNESDSSSEKGFslPI 290

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 98961138 361 DSDSCGWTFTSMSKLLRHRRKHDDD----RRFTCPVEGCGKSFTRAEHLKGHSITHLGTKPFECPVEGCCARFS------ 430
Cdd:COG5048 291 KSKQCNISFSRSSPLTRHLRSVNHSgeslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSpllnne 370

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 98961138 431 ARSSLYIHSKKHVQDvgapKSRCPVSTCNRLFTSKHSMKAH 471
Cdd:COG5048 371 PPQSLQQYKDLKNDK----KSETLSNSCIRNFKRDSNLSLH 407
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 177-286 7.42e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 36.63  E-value: 7.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 98961138   177 CPEPQCALAFAKKHQLKVHLLTHGggqgrrPFKCPLEGcgwafttsyklkrhlqshdklRPFGCPVGGCGKKFTTVYNLK 256
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHC------PPTQSLEG---------------------KLFRCSALSCTETFPSMQELV 54

                          90       100       110
                  ....*....|....*....|....*....|.
gi 98961138   257 AHMKGHEQES-LFKCEVCAERFPTHAKLSSH 286
Cdd:pfam15909  55 AHSKLHYKPNrYFKCENCLLRFRTHRSLFKH 85
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 208-232 7.72e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.72e-03
                          10        20
                  ....*....|....*....|....*
gi 98961138   208 FKCPleGCGWAFTTSYKLKRHLQSH 232
Cdd:pfam00096   1 YKCP--DCGKSFSRKSNLKRHLRTH 23
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 273-330 8.26e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 36.24  E-value: 8.26e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 98961138   273 CAERFPTHAKLSSHQRSHFEPERP-----YKCDFPGCEKTFITVSALFSHNRAHFREQELFSC 330
Cdd:pfam15909   7 CCLSFPSVRDLAQHLRTHCPPTQSlegklFRCSALSCTETFPSMQELVAHSKLHYKPNRYFKC 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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