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Conserved domains on  [gi|93102401|ref|NP_001035255|]
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methyltransferase-like 26 isoform g [Homo sapiens]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 106779)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AdoMet_MTases super family cl17173
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 4-134 4.90e-53

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


The actual alignment was detected with superfamily member pfam06080:

Pssm-ID: 473071  Cd Length: 201  Bit Score: 168.02  E-value: 4.90e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102401     4 AAAAERNKDPILHVLRQYLDPAQRgvRVLEVASGSGQHAAHFARAFPLAEWQPSDVDQRCLDSIAATTQAQGLTNVKAPL 83
Cdd:pfam06080   4 APAAERNREPILSVLQSYFAKTTE--RVLEIASGTGQHAVFFAPLLPNLTWQPSDPDPNLRGSIAAWADQQGLRNLRPPL 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 93102401    84 HLDVTWGWEHWGGILPQSLDLLLCINMAHVSPLRCTEEPRMGASGHSPPGG 134
Cdd:pfam06080  82 HLDVTRPPWPVEAPAPASYDAIFSINMIHISPWSCVEGLFRGAGRLLPPGG 132
 
Name Accession Description Interval E-value
DUF938 pfam06080
Protein of unknown function (DUF938); This family consists of several hypothetical proteins ...
 4-134 4.90e-53

Protein of unknown function (DUF938); This family consists of several hypothetical proteins from both prokaryotes and eukaryotes. The function of this family is unknown.


Pssm-ID: 253548  Cd Length: 201  Bit Score: 168.02  E-value: 4.90e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102401     4 AAAAERNKDPILHVLRQYLDPAQRgvRVLEVASGSGQHAAHFARAFPLAEWQPSDVDQRCLDSIAATTQAQGLTNVKAPL 83
Cdd:pfam06080   4 APAAERNREPILSVLQSYFAKTTE--RVLEIASGTGQHAVFFAPLLPNLTWQPSDPDPNLRGSIAAWADQQGLRNLRPPL 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 93102401    84 HLDVTWGWEHWGGILPQSLDLLLCINMAHVSPLRCTEEPRMGASGHSPPGG 134
Cdd:pfam06080  82 HLDVTRPPWPVEAPAPASYDAIFSINMIHISPWSCVEGLFRGAGRLLPPGG 132
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 12-116 4.56e-04

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 39.51  E-value: 4.56e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102401  12 DPILHVLRQYLDPAQRGVRVLEVASGSGQHAAHFARAFplaEWQPS--DVDQRCLDSIAATTQAQGLTNVKaPLHLDVTw 89
Cdd:COG0500  11 LPGLAALLALLERLPKGGRVLDLGCGTGRNLLALAARF---GGRVIgiDLSPEAIALARARAAKAGLGNVE-FLVADLA- 85

                        90       100
                ....*....|....*....|....*..
gi 93102401  90 gweHWGGILPQSLDLLLCINMAHVSPL 116
Cdd:COG0500  86 ---ELDPLPAESFDLVVAFGVLHHLPP 109
 
Name Accession Description Interval E-value
DUF938 pfam06080
Protein of unknown function (DUF938); This family consists of several hypothetical proteins ...
 4-134 4.90e-53

Protein of unknown function (DUF938); This family consists of several hypothetical proteins from both prokaryotes and eukaryotes. The function of this family is unknown.


Pssm-ID: 253548  Cd Length: 201  Bit Score: 168.02  E-value: 4.90e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102401     4 AAAAERNKDPILHVLRQYLDPAQRgvRVLEVASGSGQHAAHFARAFPLAEWQPSDVDQRCLDSIAATTQAQGLTNVKAPL 83
Cdd:pfam06080   4 APAAERNREPILSVLQSYFAKTTE--RVLEIASGTGQHAVFFAPLLPNLTWQPSDPDPNLRGSIAAWADQQGLRNLRPPL 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 93102401    84 HLDVTWGWEHWGGILPQSLDLLLCINMAHVSPLRCTEEPRMGASGHSPPGG 134
Cdd:pfam06080  82 HLDVTRPPWPVEAPAPASYDAIFSINMIHISPWSCVEGLFRGAGRLLPPGG 132
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 12-116 4.56e-04

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 39.51  E-value: 4.56e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93102401  12 DPILHVLRQYLDPAQRGVRVLEVASGSGQHAAHFARAFplaEWQPS--DVDQRCLDSIAATTQAQGLTNVKaPLHLDVTw 89
Cdd:COG0500  11 LPGLAALLALLERLPKGGRVLDLGCGTGRNLLALAARF---GGRVIgiDLSPEAIALARARAAKAGLGNVE-FLVADLA- 85

                        90       100
                ....*....|....*....|....*..
gi 93102401  90 gweHWGGILPQSLDLLLCINMAHVSPL 116
Cdd:COG0500  86 ---ELDPLPAESFDLVVAFGVLHHLPP 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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