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Conserved domains on  [gi|338968858|ref|NP_001035243|]
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SLAIN motif-containing protein 1 isoform A [Homo sapiens]

Protein Classification

SLAIN motif-containing protein( domain architecture ID 12172998)

SLAIN motif-containing protein is a microtubule plus-end tracking protein, similar to human SLAIN2 that binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SLAIN pfam15301
SLAIN motif-containing family; The SLAIN motif containing family is named after the presence ...
 46-426 2.51e-123

SLAIN motif-containing family; The SLAIN motif containing family is named after the presence of a SLAIN motif in SLAIN1. They are a family of microtubule plus-end tracking proteins.


:

Pssm-ID: 464627 [Multi-domain]  Cd Length: 420  Bit Score: 364.03  E-value: 2.51e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968858   46 LYIgSSKTFTSSEKSLTPLQWCRHVLDNPTPEMEAARRSLCFRLEQ---------------------------------- 91
Cdd:pfam15301   2 LYV-SPKKKVPSQKPLSPLKWCRQVLDHPSPETEAAKRSLIHRLDQasrwrslysspsssssaysgnaeassyssglnsp 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968858   92 ----------------GYTSRGSPLSPQSSIDSELSTSELEDDSISMGYKLQDLTDVQIMARLQEESLRQDYASTSASVS 155
Cdd:pfam15301  81 gylkstnkqlltcgssGYLRRHSALSPQSSVDSELSTSELEDDSISMGYKLQDLTDVQIMARLQEESLRQDYASTSASAS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968858  156 RHSSSVSLSSGKKGTCSDQEYDQYSLEDEEEFDhlpppqprlprCSPFQRGIPH--SQTFSSIRECRRSPSsqyfPSNNY 233
Cdd:pfam15301 161 RRSSSFSLHSLRRGTYSDQELDAYSLEDEEEEY-----------CSLPQPRLHRfsPLPHSSPRDSPRSRS----PSTSQ 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968858  234 QQQQYYSPQAQTP---------DQQPNRTNGDKLRRSMPNLARMPSttaissnISSPVTVRNSQSFDSSLHGAGNGISRI 304
Cdd:pfam15301 226 EYSRLSAQRLRQPrrslqgpgaELQKYAKSEEKLRRSMPNLARRTS-------LRSLESVRNSRSFESNLQVPNSGLSRL 298

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968858  305 Q---SCIPSPgqLQHRVHSVGHFPVSIRQPLKATAYVSPTVQGSSN-MPLSNGLQLYSNTGIPTPNKAAASGIMGRSALP 380
Cdd:pfam15301 299 QqssSSIPSP--SKLRVQSAGQSPLALRQPVKATSYVSSTVAGPSKgLPSSQSLPSGGSSGSPLPSRPSGGYSGGRSSLP 376

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 338968858  381 RPSLAING-SNLPRSKIAQPVRSFLQPPKplsSLSTLRDGNWRDGCY 426
Cdd:pfam15301 377 RPASFVGGtSPVPRSKLAQPVRRSLTPPK---TYSALRDESWKDGCY 420
 
Name Accession Description Interval E-value
SLAIN pfam15301
SLAIN motif-containing family; The SLAIN motif containing family is named after the presence ...
 46-426 2.51e-123

SLAIN motif-containing family; The SLAIN motif containing family is named after the presence of a SLAIN motif in SLAIN1. They are a family of microtubule plus-end tracking proteins.


Pssm-ID: 464627 [Multi-domain]  Cd Length: 420  Bit Score: 364.03  E-value: 2.51e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968858   46 LYIgSSKTFTSSEKSLTPLQWCRHVLDNPTPEMEAARRSLCFRLEQ---------------------------------- 91
Cdd:pfam15301   2 LYV-SPKKKVPSQKPLSPLKWCRQVLDHPSPETEAAKRSLIHRLDQasrwrslysspsssssaysgnaeassyssglnsp 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968858   92 ----------------GYTSRGSPLSPQSSIDSELSTSELEDDSISMGYKLQDLTDVQIMARLQEESLRQDYASTSASVS 155
Cdd:pfam15301  81 gylkstnkqlltcgssGYLRRHSALSPQSSVDSELSTSELEDDSISMGYKLQDLTDVQIMARLQEESLRQDYASTSASAS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968858  156 RHSSSVSLSSGKKGTCSDQEYDQYSLEDEEEFDhlpppqprlprCSPFQRGIPH--SQTFSSIRECRRSPSsqyfPSNNY 233
Cdd:pfam15301 161 RRSSSFSLHSLRRGTYSDQELDAYSLEDEEEEY-----------CSLPQPRLHRfsPLPHSSPRDSPRSRS----PSTSQ 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968858  234 QQQQYYSPQAQTP---------DQQPNRTNGDKLRRSMPNLARMPSttaissnISSPVTVRNSQSFDSSLHGAGNGISRI 304
Cdd:pfam15301 226 EYSRLSAQRLRQPrrslqgpgaELQKYAKSEEKLRRSMPNLARRTS-------LRSLESVRNSRSFESNLQVPNSGLSRL 298

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968858  305 Q---SCIPSPgqLQHRVHSVGHFPVSIRQPLKATAYVSPTVQGSSN-MPLSNGLQLYSNTGIPTPNKAAASGIMGRSALP 380
Cdd:pfam15301 299 QqssSSIPSP--SKLRVQSAGQSPLALRQPVKATSYVSSTVAGPSKgLPSSQSLPSGGSSGSPLPSRPSGGYSGGRSSLP 376

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 338968858  381 RPSLAING-SNLPRSKIAQPVRSFLQPPKplsSLSTLRDGNWRDGCY 426
Cdd:pfam15301 377 RPASFVGGtSPVPRSKLAQPVRRSLTPPK---TYSALRDESWKDGCY 420
 
Name Accession Description Interval E-value
SLAIN pfam15301
SLAIN motif-containing family; The SLAIN motif containing family is named after the presence ...
 46-426 2.51e-123

SLAIN motif-containing family; The SLAIN motif containing family is named after the presence of a SLAIN motif in SLAIN1. They are a family of microtubule plus-end tracking proteins.


Pssm-ID: 464627 [Multi-domain]  Cd Length: 420  Bit Score: 364.03  E-value: 2.51e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968858   46 LYIgSSKTFTSSEKSLTPLQWCRHVLDNPTPEMEAARRSLCFRLEQ---------------------------------- 91
Cdd:pfam15301   2 LYV-SPKKKVPSQKPLSPLKWCRQVLDHPSPETEAAKRSLIHRLDQasrwrslysspsssssaysgnaeassyssglnsp 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968858   92 ----------------GYTSRGSPLSPQSSIDSELSTSELEDDSISMGYKLQDLTDVQIMARLQEESLRQDYASTSASVS 155
Cdd:pfam15301  81 gylkstnkqlltcgssGYLRRHSALSPQSSVDSELSTSELEDDSISMGYKLQDLTDVQIMARLQEESLRQDYASTSASAS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968858  156 RHSSSVSLSSGKKGTCSDQEYDQYSLEDEEEFDhlpppqprlprCSPFQRGIPH--SQTFSSIRECRRSPSsqyfPSNNY 233
Cdd:pfam15301 161 RRSSSFSLHSLRRGTYSDQELDAYSLEDEEEEY-----------CSLPQPRLHRfsPLPHSSPRDSPRSRS----PSTSQ 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968858  234 QQQQYYSPQAQTP---------DQQPNRTNGDKLRRSMPNLARMPSttaissnISSPVTVRNSQSFDSSLHGAGNGISRI 304
Cdd:pfam15301 226 EYSRLSAQRLRQPrrslqgpgaELQKYAKSEEKLRRSMPNLARRTS-------LRSLESVRNSRSFESNLQVPNSGLSRL 298

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 338968858  305 Q---SCIPSPgqLQHRVHSVGHFPVSIRQPLKATAYVSPTVQGSSN-MPLSNGLQLYSNTGIPTPNKAAASGIMGRSALP 380
Cdd:pfam15301 299 QqssSSIPSP--SKLRVQSAGQSPLALRQPVKATSYVSSTVAGPSKgLPSSQSLPSGGSSGSPLPSRPSGGYSGGRSSLP 376

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 338968858  381 RPSLAING-SNLPRSKIAQPVRSFLQPPKplsSLSTLRDGNWRDGCY 426
Cdd:pfam15301 377 RPASFVGGtSPVPRSKLAQPVRRSLTPPK---TYSALRDESWKDGCY 420
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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