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Conserved domains on  [gi|4507041|ref|NP_001035|]
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sodium-dependent dopamine transporter [Homo sapiens]

Protein Classification

SLC5/6 family protein; sodium:solute symporter family protein( domain architecture ID 10183834)

SLC5/6 (solute carrier 5/6) family protein may function as a transporter; sodium:solute symporter family protein uses a sodium gradient to drive the transport of various solutes, such as sugars, amino acids, vitamins, or ions across the membrane

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SLC6sbd_DAT1 cd11514
Na(+)- and Cl(-)-dependent dopamine transporter 1; solute-binding domain; DAT1 (also called ...
60-614 0e+00

Na(+)- and Cl(-)-dependent dopamine transporter 1; solute-binding domain; DAT1 (also called DAT), is a plasma membrane transport protein that functions at the dopaminergic synapses to transport dopamine from the extracellular space back into the presynaptic nerve terminal. Human DAT1 is encoded by the SLC6A3 gene, and is expressed in the brain. DAT1 may play a role in diseases or disorders related to dopaminergic neurons, including attention-deficit hyperactivity disorder (ADHD), Tourette syndrome, Parkinson's disease, alcoholism, drug abuse, schizophrenia, extraversion, and risky behavior. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


:

Pssm-ID: 212083  Cd Length: 555  Bit Score: 1110.38  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   60 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILK 139
Cdd:cd11514   1 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLFFMVIAGMPLFYMELALGQFNREGAAGVWKICPIFK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  140 GVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFER 219
Cdd:cd11514  81 GVGFTVILISLYVGFFYNVIIAWALFYLFSSFTGELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTYKTTPAAEYFER 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  220 GVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLS 299
Cdd:cd11514 161 GVLHLHESHGIHDLGPPRWQLTSCLVVVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIKAYLS 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  300 VDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVPI 379
Cdd:cd11514 241 VDFLRLCEASVWIDAATQICFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFFSGFVVFSFLGYMAQKHNVPI 320
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  380 GDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLL 459
Cdd:cd11514 321 GDVAKDGPGLIFIIYPEAIATLPLSSVWAVIFFIMLLTLGIDSAMGGMESVITGLIDEFKFLHRHRELFTLFIVLSTFLI 400
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  460 SLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVS 539
Cdd:cd11514 401 SLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGIAWFYGVGRFSDDIEEMIGQRPGLYWRLCWKFVSPCFLLFVVVVS 480
                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4507041  540 IVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKDRELVDRGEVRQFTL 614
Cdd:cd11514 481 IVTFRPPKYGSYIFPDWANMVGWCLAISSMAMVPLYAIYKFCSLPGSFREKLAYAITPEKEHELVDRGEVRQFTL 555
 
Name Accession Description Interval E-value
SLC6sbd_DAT1 cd11514
Na(+)- and Cl(-)-dependent dopamine transporter 1; solute-binding domain; DAT1 (also called ...
60-614 0e+00

Na(+)- and Cl(-)-dependent dopamine transporter 1; solute-binding domain; DAT1 (also called DAT), is a plasma membrane transport protein that functions at the dopaminergic synapses to transport dopamine from the extracellular space back into the presynaptic nerve terminal. Human DAT1 is encoded by the SLC6A3 gene, and is expressed in the brain. DAT1 may play a role in diseases or disorders related to dopaminergic neurons, including attention-deficit hyperactivity disorder (ADHD), Tourette syndrome, Parkinson's disease, alcoholism, drug abuse, schizophrenia, extraversion, and risky behavior. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212083  Cd Length: 555  Bit Score: 1110.38  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   60 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILK 139
Cdd:cd11514   1 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLFFMVIAGMPLFYMELALGQFNREGAAGVWKICPIFK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  140 GVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFER 219
Cdd:cd11514  81 GVGFTVILISLYVGFFYNVIIAWALFYLFSSFTGELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTYKTTPAAEYFER 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  220 GVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLS 299
Cdd:cd11514 161 GVLHLHESHGIHDLGPPRWQLTSCLVVVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIKAYLS 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  300 VDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVPI 379
Cdd:cd11514 241 VDFLRLCEASVWIDAATQICFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFFSGFVVFSFLGYMAQKHNVPI 320
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  380 GDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLL 459
Cdd:cd11514 321 GDVAKDGPGLIFIIYPEAIATLPLSSVWAVIFFIMLLTLGIDSAMGGMESVITGLIDEFKFLHRHRELFTLFIVLSTFLI 400
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  460 SLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVS 539
Cdd:cd11514 401 SLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGIAWFYGVGRFSDDIEEMIGQRPGLYWRLCWKFVSPCFLLFVVVVS 480
                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4507041  540 IVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKDRELVDRGEVRQFTL 614
Cdd:cd11514 481 IVTFRPPKYGSYIFPDWANMVGWCLAISSMAMVPLYAIYKFCSLPGSFREKLAYAITPEKEHELVDRGEVRQFTL 555
SNF pfam00209
Sodium:neurotransmitter symporter family; These are twelve xTM-containing region transporters.
60-581 0e+00

Sodium:neurotransmitter symporter family; These are twelve xTM-containing region transporters.


Pssm-ID: 395155 [Multi-domain]  Cd Length: 517  Bit Score: 813.83  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041     60 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVW-KICPIL 138
Cdd:pfam00209   1 RETWSGKLDFLLSVIGFAVGLGNVWRFPYLCYKNGGGAFLIPYLIMLIFAGIPLFFLELALGQYTREGAIGVWrKICPLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041    139 KGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHpgdssGDSSGLNDTFGTTPAAEYFE 218
Cdd:pfam00209  81 KGIGYASMVIAFYIGIYYNVIIAWALYYLFSSFTTELPWASCNNSWNTPNCTEFF-----SANNTTNSLNKTSPVEEFWE 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041    219 RGVLHLHQshGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYL 298
Cdd:pfam00209 156 RKVLKLSD--GIEDLGGLRWPLALCLLVAWVVVYFCIWKGVKSSGKVVYFTATFPYVVLLVLLVRGVTLPGAADGILFYL 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041    299 SVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVP 378
Cdd:pfam00209 234 TPDWSKLLEPQVWIDAATQIFFSLGIGFGGLIAFASYNKFHNNCYRDALIVSFINSATSFLAGFVIFSVLGFMAQEQGVP 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041    379 IGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHR-HRELFTLFIVLATF 457
Cdd:pfam00209 314 ISEVAESGPGLAFIAYPEAVTMLPLSPFWSVLFFLMLITLGLDSQFGGVEGIITALVDEFPILLRkRRELFTLIVCVASF 393
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041    458 LLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVV 537
Cdd:pfam00209 394 LLGLILVTEGGIYVFTLFDYYAASFSLLFVAFFECIAIAWVYGIDRFYDDIKEMLGFRPGLFWRLCWKFVSPLILLFLFI 473
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....
gi 4507041    538 VSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFC 581
Cdd:pfam00209 474 FSIVQYQPLTYNNYVYPNWANALGWLMALSSMLCIPLYSIYKLL 517
YocR COG0733
Na+-dependent transporter, SNF family [General function prediction only];
56-540 6.16e-92

Na+-dependent transporter, SNF family [General function prediction only];


Pssm-ID: 440497 [Multi-domain]  Cd Length: 444  Bit Score: 290.85  E-value: 6.16e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   56 EAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKIC 135
Cdd:COG0733   1 ASSKREQWSSRLGFILAAAGSAVGLGNIWRFPYVAGENGGGAFLLPYLLALLLIGIPLLIAEFAIGRRGRKSPVGAFRKL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  136 ---PILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPwihcnnswnspncsdahpGDSSGDSSGLNDTFGTTP 212
Cdd:COG0733  81 apgKKWEWIGWLGVLGAFLILSYYSVVAGWVLAYLFKSLTGAFG------------------GLDAEDAGAFFGAFLSSP 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  213 aaeyfergvlhlhqshgiddlgpprWQLTACLVLVIVLLYFSLWKGVKTS-GKVVWITatMP--YVVLTALLLRGVTLPG 289
Cdd:COG0733 143 -------------------------GEVLIWHLLFLLLTALIVARGVQKGiEKASKIL--MPllFVLLIILVIRALTLPG 195
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  290 AIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLg 369
Cdd:COG0733 196 AAEGLKFLFTPDFSKLTDPEVWLAALGQAFFSLSLGMGIMITYGSYLPKDEDLPRSALIVALLDTLVALLAGLAIFPAV- 274
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  370 YMAqkhsvpiGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLlhrHRELFT 449
Cdd:COG0733 275 FAF-------GLEPAAGPGLAFVTLPAVFAQMPGGRLFGVLFFLLLLFAALTSAISLLEVVVAALIDKFGL---SRKKAT 344
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  450 LFIVLATFLLSLFCVTNG------GIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLC 523
Cdd:COG0733 345 LIVGLLIFLLGIPSALSFnvsvtiGLTFFDLVDFLVSNILLPLGGLLIAIFVGWVLGKEKLREELNAGSDIKLGKWWRFL 424
                       490
                ....*....|....*..
gi 4507041  524 WKLVSPCFLLFVVVVSI 540
Cdd:COG0733 425 IRYVAPVALLIIFLNGL 441
Na_transp NF037979
sodium-dependent transporter;
65-495 3.36e-04

sodium-dependent transporter;


Pssm-ID: 468298 [Multi-domain]  Cd Length: 417  Bit Score: 43.38  E-value: 3.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041    65 KKIDFLLS--VIGFAVDLANVWRFPYLCYKNGGGAFLVpYLLFMVIA-GMPLFYMELALGQ-------FNREGAAGVWKI 134
Cdd:NF037979   1 RKWTLYLIflVAGYAVGIGTFWLFPQFWLQYGLTGLVV-YLIFLAVLtYLAILEAESTKKSryyivelYTKVARTPAMIL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   135 cpilkgVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPwihcnnswnspncsdahpgdssgdssglndtfgttpaa 214
Cdd:NF037979  80 ------VLLMFLVIFLGVISYYTANGGLLLSPILGTGTLGIL-------------------------------------- 115
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   215 eyfergvlhlhqshgiddlgpprwqLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGi 294
Cdd:NF037979 116 -------------------------IAKLLMILLAFLILTRAKEKTLDIMAIGSVLFVIFVVVSAILFRSQVLSVAPQA- 169
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   295 RAYLSVDFYRLCE-----ASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLG 369
Cdd:NF037979 170 AQYLSMAKSMIFSfhpitLKLVVDMALQAIYSLGLGFGFYLVLGSFLPERFNAKKIIGIGILLQTLLSFLATFTVVYSLG 249
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   370 YMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQlLHRHRELFT 449
Cdd:NF037979 250 PAHPGYLTAFVYGGEEEAISLFYSLPLILRDVPGGPTLLYLLMLSLFLAGLTSILPLGEVGGQIISEVFQ-LGRNKALIY 328
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 4507041   450 LFIVlaTFLLSLFCVTNGGIYVFTLldhfAAGTSILFGVLIEAIGV 495
Cdd:NF037979 329 VLGI--SLVLGGIDSLPSIATMLLK----AVSVFIFFTAIVEAYPL 368
 
Name Accession Description Interval E-value
SLC6sbd_DAT1 cd11514
Na(+)- and Cl(-)-dependent dopamine transporter 1; solute-binding domain; DAT1 (also called ...
60-614 0e+00

Na(+)- and Cl(-)-dependent dopamine transporter 1; solute-binding domain; DAT1 (also called DAT), is a plasma membrane transport protein that functions at the dopaminergic synapses to transport dopamine from the extracellular space back into the presynaptic nerve terminal. Human DAT1 is encoded by the SLC6A3 gene, and is expressed in the brain. DAT1 may play a role in diseases or disorders related to dopaminergic neurons, including attention-deficit hyperactivity disorder (ADHD), Tourette syndrome, Parkinson's disease, alcoholism, drug abuse, schizophrenia, extraversion, and risky behavior. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212083  Cd Length: 555  Bit Score: 1110.38  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   60 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILK 139
Cdd:cd11514   1 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLFFMVIAGMPLFYMELALGQFNREGAAGVWKICPIFK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  140 GVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFER 219
Cdd:cd11514  81 GVGFTVILISLYVGFFYNVIIAWALFYLFSSFTGELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTYKTTPAAEYFER 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  220 GVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLS 299
Cdd:cd11514 161 GVLHLHESHGIHDLGPPRWQLTSCLVVVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIKAYLS 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  300 VDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVPI 379
Cdd:cd11514 241 VDFLRLCEASVWIDAATQICFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFFSGFVVFSFLGYMAQKHNVPI 320
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  380 GDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLL 459
Cdd:cd11514 321 GDVAKDGPGLIFIIYPEAIATLPLSSVWAVIFFIMLLTLGIDSAMGGMESVITGLIDEFKFLHRHRELFTLFIVLSTFLI 400
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  460 SLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVS 539
Cdd:cd11514 401 SLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGIAWFYGVGRFSDDIEEMIGQRPGLYWRLCWKFVSPCFLLFVVVVS 480
                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4507041  540 IVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKDRELVDRGEVRQFTL 614
Cdd:cd11514 481 IVTFRPPKYGSYIFPDWANMVGWCLAISSMAMVPLYAIYKFCSLPGSFREKLAYAITPEKEHELVDRGEVRQFTL 555
SLC6sbd_SERT-like cd11497
Na(+)- and Cl(-)-dependent monoamine transporters, SERT, NET, DAT1 and related proteins; ...
60-598 0e+00

Na(+)- and Cl(-)-dependent monoamine transporters, SERT, NET, DAT1 and related proteins; solute binding domain; This subgroup represents the solute-binding domain of transmembrane transporters that transport monoamine neurotransmitters from synaptic spaces into presynaptic neurons. Members include: NET which transports norepinephrine, SERT which transports serotonin, and DAT1 which transports dopamine. These transporters may play a role in diseases including depression, anxiety disorders, attention-deficit hyperactivity disorder, and in the control of human behavior and emotional states. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271388  Cd Length: 537  Bit Score: 959.08  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   60 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVW-KICPIL 138
Cdd:cd11497   1 RETWGKKIDFLLSVIGFAVDLGNVWRFPYLCYKNGGGAFLIPYLIMLIFGGLPLFYMELALGQFNRSGCITVWkKICPLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  139 KGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDssgDSSGLNDTFGTTPAAEYFE 218
Cdd:cd11497  81 KGVGYAICIIAFYVAFYYNVIIAWALYYLFSSFTSELPWTSCNNPWNTPNCTDVSNRN---NSSSINGTGLTSPAEEYFE 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  219 RGVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYL 298
Cdd:cd11497 158 RKVLELQKSEGIDDLGPIKWQLALCLFAVFIIVYFSLWKGVKSSGKVVWVTATMPYVVLSILLIRGLTLPGASDGIKYYL 237
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  299 SVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVP 378
Cdd:cd11497 238 TPDFSKLKDPEVWIDAATQIFFSLGPGFGVLLALSSYNKFHNNCYRDALVTSSINCATSFFSGFVIFSVLGYMAHKQNVP 317
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  379 IGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFL 458
Cdd:cd11497 318 IEDVATEGPGLVFIVYPEAIATLPGSTFWAIIFFLMLITLGLDSTFGGLEAVITGLCDEFPFLSRRRELFVLGLVIICFL 397
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  459 LSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVV 538
Cdd:cd11497 398 LALPTVTYGGIYVVTLLDRYAAGISILFIVFFEAVAVSWFYGVDRFSDDIEEMLGFRPGLYWRVCWKFISPIFLLFIVIF 477
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  539 SIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPE 598
Cdd:cd11497 478 SLVSYEPLQYQDYVYPPWANVVGWVIACSSIVLIPIYAIYKLISTPGTFRQRIAYCITPE 537
SLC6sbd_NET cd11512
Na(+)- and Cl(-)-dependent norepinephrine transporter NET; solute-binding domain; NET (also ...
60-618 0e+00

Na(+)- and Cl(-)-dependent norepinephrine transporter NET; solute-binding domain; NET (also called NAT1, NET1), is a transmembrane transporter that transports the neurotransmitter norepinephrine from synaptic spaces into presynaptic neurons. Human NET is encoded by the SLC6A2 gene. NET is expressed in brain, peripheral nervous system, adrenal gland, and placenta. NET may play a role in diseases or disorders including depression, orthostatic intolerance, anorexia nervosa, cardiovascular diseases, alcoholism, and attention-deficit hyperactivity disorder. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212081  Cd Length: 560  Bit Score: 869.28  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   60 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILK 139
Cdd:cd11512   1 RETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPCFK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  140 GVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLN-DTFGTTPAAEYFE 218
Cdd:cd11512  81 GVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTSELPWTTCGNVWNSPNCTDPKLLNASVLGNGTKySKYKLTPAAEFYE 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  219 RGVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYL 298
Cdd:cd11512 161 RGVLHLHESAGIHDLGLPRWQLTLCLFVVVIVLFFSLWKGVKTSGKVVWITATLPYVVLFVLLIHGVTLPGAFNGINAYL 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  299 SVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVP 378
Cdd:cd11512 241 HIDFKRLKEATVWIDAATQIFYSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFAIFSILGYMAHEHKVK 320
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  379 IGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFL 458
Cdd:cd11512 321 IEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFIMLLTLGIDSSMGGMEAVITGLADDFSILKKHRKLFTFGVAFITFL 400
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  459 LSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVV 538
Cdd:cd11512 401 LALFCITNGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSDDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVIV 480
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  539 SIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKDRELVDRGEVRQFTLRHWL 618
Cdd:cd11512 481 SIINFKPLTYDDYNFPPWANRTGWGIALSSMLLVPIYVIYKFFTVPGTFEERLAYCITPENEHYLVAQGDIRQFKLQHWL 560
SNF pfam00209
Sodium:neurotransmitter symporter family; These are twelve xTM-containing region transporters.
60-581 0e+00

Sodium:neurotransmitter symporter family; These are twelve xTM-containing region transporters.


Pssm-ID: 395155 [Multi-domain]  Cd Length: 517  Bit Score: 813.83  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041     60 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVW-KICPIL 138
Cdd:pfam00209   1 RETWSGKLDFLLSVIGFAVGLGNVWRFPYLCYKNGGGAFLIPYLIMLIFAGIPLFFLELALGQYTREGAIGVWrKICPLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041    139 KGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHpgdssGDSSGLNDTFGTTPAAEYFE 218
Cdd:pfam00209  81 KGIGYASMVIAFYIGIYYNVIIAWALYYLFSSFTTELPWASCNNSWNTPNCTEFF-----SANNTTNSLNKTSPVEEFWE 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041    219 RGVLHLHQshGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYL 298
Cdd:pfam00209 156 RKVLKLSD--GIEDLGGLRWPLALCLLVAWVVVYFCIWKGVKSSGKVVYFTATFPYVVLLVLLVRGVTLPGAADGILFYL 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041    299 SVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVP 378
Cdd:pfam00209 234 TPDWSKLLEPQVWIDAATQIFFSLGIGFGGLIAFASYNKFHNNCYRDALIVSFINSATSFLAGFVIFSVLGFMAQEQGVP 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041    379 IGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHR-HRELFTLFIVLATF 457
Cdd:pfam00209 314 ISEVAESGPGLAFIAYPEAVTMLPLSPFWSVLFFLMLITLGLDSQFGGVEGIITALVDEFPILLRkRRELFTLIVCVASF 393
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041    458 LLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVV 537
Cdd:pfam00209 394 LLGLILVTEGGIYVFTLFDYYAASFSLLFVAFFECIAIAWVYGIDRFYDDIKEMLGFRPGLFWRLCWKFVSPLILLFLFI 473
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....
gi 4507041    538 VSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFC 581
Cdd:pfam00209 474 FSIVQYQPLTYNNYVYPNWANALGWLMALSSMLCIPLYSIYKLL 517
SLC6sbd_SERT-like_u1 cd11556
uncharacterized subgroup of the SERT-like Na(+)- and Cl(-)-dependent monoamine transporter ...
60-597 0e+00

uncharacterized subgroup of the SERT-like Na(+)- and Cl(-)-dependent monoamine transporter subfamily; solute binding domain; SERT-like Na(+)- and Cl(-)-dependent monoamine transporters, transport monoamine neurotransmitters from synaptic spaces into presynaptic neurons. Members include: the norepinephrine transporter NET, the serotonin transporter SERT , and the dopamine transporter DAT1. These latter may play a role in diseases or disorders including depression, anxiety disorders, and attention-deficit hyperactivity disorder, and in the control of human behavior and emotional states. They belongs to the solute carrier 6 (SLC6) transporter family. Members of this subgroup are uncharacterized.


Pssm-ID: 271405  Cd Length: 552  Bit Score: 718.10  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   60 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVW-KICPIL 138
Cdd:cd11556   1 RETWSKKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLIPYGIMLVVGGIPLFYMELALGQYNRKGAITSWgRLCPLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  139 KGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPG------------DSSGDSSGLND 206
Cdd:cd11556  81 KGIGYAVVLIAFYVDFFYNVIIAWSLYYFFASFTFNLPWTSCNNSWNTPNCREFHWSedgtvpcrsanqSFSAENQSAQS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  207 TFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVT 286
Cdd:cd11556 161 ENFTSAASEYFERGVLELNRSEGVHDLGNIRWDIALCLFAVYLICYFSLWKGIHTSGKVVWFTALFPYVVLFILLIRGVT 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  287 LPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFS 366
Cdd:cd11556 241 LPGSFNGIQYYLTPNFEALKKAEVWVDAATQVFFSLGPGFGVLLAYASYNKFHNNVYKDALLTSFINCATSFLSGFVIFS 320
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  367 FLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRE 446
Cdd:cd11556 321 VLGYMAHRSGVPIEDVATEGPGLVFVVYPEALSTMPGSTFWSLIFFMMLMTLGLDSSFGGSEAIITALSDEFPIIKRHRE 400
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  447 LFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKL 526
Cdd:cd11556 401 LFVGCLFSFYFVIGLASCTQGGFYFFHLLDRYAAGYSILIAVLFEAIAVSWIYGTDRFCQDIKEMLGFPPGIYWKVCWKF 480
                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4507041  527 VSPCFLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAP 597
Cdd:cd11556 481 IAPIFLLFIITYGLIGYQPLTYDDYVYPTWANALGWCIAGSSISMIPIVAIYKLLSTPGTLRQRFKILTTP 551
SLC6sbd-TauT-like cd11496
Na(+)- and Cl(-)-dependent taurine transporter TauT, and related proteins; solute-binding ...
60-597 0e+00

Na(+)- and Cl(-)-dependent taurine transporter TauT, and related proteins; solute-binding domain; This subgroup represents the solute-binding domain of TauT-like Na(+)- and Cl(-)-dependent transporters. Family members include: human TauT which transports taurine, human GAT1, GAT2, and GAT3, and BGT1, which transport gamma-aminobutyric acid (GABA), and human CT1 which transports creatine. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271387  Cd Length: 543  Bit Score: 690.09  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   60 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILK 139
Cdd:cd11496   1 RGKWSNKIDFLLSVAGYAIGLGNVWRFPYLCYKNGGGAFLIPYFIFLVLCGIPIFFLETSLGQYTSQGGITAWKICPLFK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  140 GVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGD--SSGDSSGLNDTFGTTPAAEYF 217
Cdd:cd11496  81 GIGYASAVIVFWLNIYYIVILAWALFYLFNSFTSPLPWTTCDNWWNTECCVEFYSNNnlSNSRENASNNTNATSPVEEFW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  218 ERGVLHLhqSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAY 297
Cdd:cd11496 161 ERRVLGI--SDGIDEIGSIRWELVLCLLLAWVIVYFCIWKGVKSTGKVVYFTATFPYVMLIILLIRGVTLPGASDGIKFY 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  298 LSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSV 377
Cdd:cd11496 239 LKPDLTKLLDPQVWIDAGTQIFFSYGIGLGSLTALGSYNKFNNNCYKDSIILCFLNSGTSFFAGFAIFSILGFMAQEQGV 318
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  378 PIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHR---HRELFTLFIVL 454
Cdd:cd11496 319 PISEVAESGPGLAFIAYPRAVSLLPLPQLWAVLFFIMLLLLGLDSQFVGVEGFVTAIVDLYPRVLRrryRREIFVAIVCL 398
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  455 ATFLLSLFCVTNGGIYVFTLLDHFAA-GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLL 533
Cdd:cd11496 399 VSFLIGLPMVTEGGIYVFQLFDYYAAsGICLLWLAFFECIAISWVYGADRFYDNIKDMIGYRPGPWWKYCWLFGTPAICL 478
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4507041  534 FVVVVSIVTFRPPHYGA-YIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAP 597
Cdd:cd11496 479 GIFIFSLVKYTPLTYGNtYVYPWWAEAIGWFLALSSMLCIPLYAIYELLRTPGTFKERLRKLTTP 543
SLC6sbd_SERT cd11513
Na(+)- and Cl(-)-dependent serotonin transporter SERT; solute-binding domain; SERT (also ...
60-598 0e+00

Na(+)- and Cl(-)-dependent serotonin transporter SERT; solute-binding domain; SERT (also called 5-HTT), is a transmembrane transporter that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The antiport of a K+ ion is believed to follow the transport of serotonin and promote the reorientation of SERT for another transport cycle. Human SERT is encoded by the SLC6A4 gene. SERT is expressed in brain, peripheral nervous system, placenta, epithelium, and platelets. SERT may play a role in diseases or disorders including anxiety, depression, autism, gastrointestinal disorders, premature ejaculation, and obesity. It may also have a role in social cognition. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271399  Cd Length: 537  Bit Score: 643.80  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   60 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVW-KICPIL 138
Cdd:cd11513   1 RETWGKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLIPYTIMAIFGGIPLFYMELALGQYHRNGCISIWrKICPIF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  139 KGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDssgDSSGLNDTfgTTPAAEYFE 218
Cdd:cd11513  81 KGIGYAICIIALYVASYYNTIIAWALYYLYSSFTDELPWTSCNNSWNTGNCTNYFAKD---NITWTLHS--TSPAEEFYT 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  219 RGVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYL 298
Cdd:cd11513 156 RHVLQVHRSKGLGDLGGISWQLTLCLFLIFTIVYFSIWKGVKTSGKVVWVTATFPYIVLFILLVRGATLPGAWRGVVFYL 235
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  299 SVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVP 378
Cdd:cd11513 236 KPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLALASYNKFNNNCYQDALVTSVVNCLTSFVSGFVIFTVLGYMAEMRNED 315
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  379 IGDVAKD-GPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEF-QLLHRHRELFTLFIVLAT 456
Cdd:cd11513 316 VSEVAKDaGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFpHVWSKRREKFVLGLVIVC 395
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  457 FLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVV 536
Cdd:cd11513 396 FLGSLATLTFGGAYVVKLLEEYATGPAVLTVVLLEAVAVSWFYGITQFCNDVKEMLGFSPGWFWRVCWVAISPLFLLFII 475
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4507041  537 VVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPE 598
Cdd:cd11513 476 CSFLMNPPQLRLFDYNYPYWSIVVGYCIGTSSIICIPIYMAYRLIITPGTLKERIIKSITPE 537
SLC6sbd_PROT cd11500
Na(+)- and Cl(-)-dependent L-proline transporter PROT; solute-binding domain; PROT is a ...
60-600 0e+00

Na(+)- and Cl(-)-dependent L-proline transporter PROT; solute-binding domain; PROT is a high-affinity L-proline transporter that transports L-proline, and may have a role in excitatory neurotransmission. Human PROT is encoded by the SLC6A7 gene, a potential susceptible gene for asthma. PROT is expressed in the brain. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271390  Cd Length: 541  Bit Score: 613.68  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   60 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILK 139
Cdd:cd11500   1 RGQWGGKLEFLLSCIGYCVGLGNVWRFPYLCYRNGGGAFLIPYFIMLAFCGIPLFFMELSLGQYGSLGPLTVWKCCPIFK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  140 GVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAhpgdSSGDSSGLNDTFGTTPAAEYFER 219
Cdd:cd11500  81 GIGYGMLLVSGLVCIYYNVIIAWTLFYLFASFTSVLPWEHCGNWWNTESCLEH----RGNGALTVNLTRTVSPSEEYWNR 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  220 GVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLS 299
Cdd:cd11500 157 RVLGIQGSSGIGDPGEVRWELALCLLLAWVIVFFCLFKGVKSSGKVVYFTATFPYIILIVLLVRGVTLEGALKGIQFYLT 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  300 VDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVPI 379
Cdd:cd11500 237 PDFHRLASSQVWYDAASQIFYSLGIGFGGLLTMASYNKFNNNIYRDTLIITLGNCITSVFAGFAIFSVLGHMAHELGVPV 316
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  380 GDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEF-QLLHRHRELFTLFIVLATFL 458
Cdd:cd11500 317 KDVADAGPGLAFVAYPEALTLLPVSPFWSILFFFMLLTLGLDSQFAMLETIVTAVTDEFpYLLRKYKTWFLGLICVGMYL 396
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  459 LSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVV 538
Cdd:cd11500 397 LGLLLVTDGGMYWLTLMDWYSASFGLMVLALFMCLAISWVYGIQRFCRDIKMMIGFEPNLYFKACWMFISPALLLFILVY 476
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4507041  539 SIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD 600
Cdd:cd11500 477 SIVKYQPSEYGSYRYPPWAELLGILMGLLSCLMIPIGAIVAILREEGSLWERLKQACRPAMD 538
SLC6sbd_GAT1 cd11506
Na(+)- and Cl(-)-dependent GABA transporter 1; solute-binding domain; GAT1 transports ...
56-600 0e+00

Na(+)- and Cl(-)-dependent GABA transporter 1; solute-binding domain; GAT1 transports gamma-aminobutyric acid (GABA). GABA is the main inhibitory neurotransmitter within the mammalian CNS. Human GAT1 is encoded by the SLC6A1 gene. GAT1 is expressed in brain and peripheral nervous system. The antiepileptic drug, Tiagabine, inhibits GAT1. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212075 [Multi-domain]  Cd Length: 598  Bit Score: 573.85  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   56 EAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKIC 135
Cdd:cd11506  39 DLPDRDTWKGKFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLA 118
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  136 PILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHpgdssgdsSGLNDTFGTTPAAE 215
Cdd:cd11506 119 PMFKGVGLAAAVLSFWLNIYYIVIIAWAIYYLYNSFTTTLPWKSCDNPWNTDRCFSNY--------SMANTTNMTSAVVE 190
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  216 YFERgvlHLHQ-SHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGI 294
Cdd:cd11506 191 FWER---NMHQmTDGLEKPGQIRWPLAITLAIAWVLVYFCIWKGVGWTGKVVYFSATYPYIMLFILFFRGVTLPGAKEGI 267
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  295 RAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQK 374
Cdd:cd11506 268 LFYITPNFSKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNPFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHV 347
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  375 HSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEF-QLLHRHRELFTLFIV 453
Cdd:cd11506 348 TKRPIADVAASGPGLAFLAYPEAVTQLPISPLWAVLFFSMLLMLGIDSQFCTVEGFITALVDEFpRLLRNRREIFIAVVC 427
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  454 LATFLLSLFCVTNGGIYVFTLLDHF-AAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFL 532
Cdd:cd11506 428 IVSYLIGLSNITQGGIYVFKLFDYYsASGMSLLFLVFFECVSISWFYGVNRFYDNIEEMVGYRPCIWWKLCWSFFTPIIV 507
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4507041  533 LFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD 600
Cdd:cd11506 508 AGVFLFSAVQMTPLTMGNYVFPKWGQGVGWFMALSSMVLIPGYMAYMFLTLKGSLKQRLQVMIQPTED 575
SLC6sbd_GlyT2 cd11499
Na(+)- and Cl(-)-dependent glycine transporter GlyT2; solute-binding domain; GlyT2 (also ...
60-600 0e+00

Na(+)- and Cl(-)-dependent glycine transporter GlyT2; solute-binding domain; GlyT2 (also called NET1) is a membrane-bound transporter that re-uptakes glycine from the synaptic cleft. Human GlyT2 is encoded by the SLC6A5 gene. GlyT2 is expressed in brain and spinal cord. GlyT2 may play a role in pain, and in spasticity. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271389  Cd Length: 597  Bit Score: 543.44  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   60 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILK 139
Cdd:cd11499   1 RGNWSNKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLIMLALAGLPIFLLEVSLGQFASQGPVSVWKAIPALQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  140 GVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSD---------------------------A 192
Cdd:cd11499  81 GCGIAMLIISVLIAIYYNIIMCYTLFYLFASLVEVLPWASCNNPWNTPECKDkdmllldsciisdrpiiqiknstfcmtA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  193 HPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLhqSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATM 272
Cdd:cd11499 161 YPNVTMVNFTSVDNKTFVSGSEEYFKYNVLKI--SAGIEYPGEIRWPLAACLFLAWLIVYASLAKGIKTSGKVVYFTATF 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  273 PYVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSI 352
Cdd:cd11499 239 PYVVLVILLIRGVTLPGAGSGIWYFITPKWEKLNDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCT 318
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  353 NSLTSFSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVIT 432
Cdd:cd11499 319 NSATSIFAGFVIFSVIGFMAHELKVPIESVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVT 398
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  433 GLIDEF-QLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQM 511
Cdd:cd11499 399 SVSDEFpKYLRTHKPQFTLVCCLSFFIMGFPMITQGGIYMLQLVDTYAASYSLVIIAIFELVGISYIYGLQRFCEDIEMM 478
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  512 TGQRPSLYWRLCWKLVSPCFLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKL 591
Cdd:cd11499 479 IGFQPNKFWKVCWAFVTPTILTFILAFSFYQWEPMTYGSYTYPNWSMVLGWLMLACSVIWIPIMFVIKMHLAPGSFIERL 558

                ....*....
gi 4507041  592 AYAIAPEKD 600
Cdd:cd11499 559 KLVCSPQPD 567
SLC6sbd_BGT1 cd11511
Na(+)- and Cl(-)-dependent betaine/GABA transporter-1, and related proteins; solute-binding ...
59-597 0e+00

Na(+)- and Cl(-)-dependent betaine/GABA transporter-1, and related proteins; solute-binding domain; BGT1 is a relatively low-affinity transporter of gamma-aminobutyric acid (GABA), and can also transport betaine. GABA is the main inhibitory neurotransmitter within the mammalian CNS. Human BGT1 is encoded by the SLC6A12 gene, and is similar to mouse GAT2. Mouse GAT2 plays a role in transporting GABA across the blood-brain barrier. In addition to being expressed in cells of the central nervous system, BGT1 is expressed in peripheral tissues, including kidney, liver, and heart. An association has been shown between the SLC6A12 gene and the occurrence of aspirin-intolerant asthma, and BGT1 is a drug target for antiepileptic drugs. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212080  Cd Length: 541  Bit Score: 542.21  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   59 DRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVW-KICPI 137
Cdd:cd11511   1 ERGQWRNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYLIFLFTCGIPLFFLETALGQYTSQGGVTAWrKICPI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  138 LKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDaHPGDSSGDSSGLNDTFgTTPAAEYF 217
Cdd:cd11511  81 FEGIGYASQVIESYLNVYYIIILSWALFYLFSSFTSVLPWATCNNPWNSDLCVD-FLNHSGADNRTPPENA-TSPVMEFW 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  218 ERGVLHLhqSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAY 297
Cdd:cd11511 159 EKRVLGL--TDGIHKLGTVRWELALCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLVILLVRGVTLPGAAEGIIFY 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  298 LSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSV 377
Cdd:cd11511 237 LKPDLSRLADPQVWMDAGTQILFSYAICQGCLTALGSYNKYTNNCYRDCIMLCFLNSATSFVAGFAIFSVLGFMAREQGV 316
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  378 PIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHR---HRELFTLFIVL 454
Cdd:cd11511 317 PISEVAESGPGLAFIAYPTAVTMMPVSQLWSCLFFLMLIFLGLDSQFVCVESMVTASIDMFPGVFRkkgRRELLILAIAV 396
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  455 ATFLLSLFCVTNGGIYVFTLLDHFAA-GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLL 533
Cdd:cd11511 397 ICYLLGLLLVTEGGMYIFQLFDYYAAsGTCLLFLAIFEVICIGWVYGANRFYDNIEDMIGYRPWPLIKICWLVFTPGLCL 476
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4507041  534 FVVVVSIVTFRPPHY-GAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAP 597
Cdd:cd11511 477 AVFLFSLIKYTPLKYnNSYVYPPWGYVLGWLMALSSMVCIPLYAIFILLKTKGSLKQRLMQLISP 541
SLC6sbd_TauT cd11510
Na(+)- and Cl(-)-dependent taurine transporter; solute-binding domain; TauT is a Na(+)- and Cl ...
60-597 0e+00

Na(+)- and Cl(-)-dependent taurine transporter; solute-binding domain; TauT is a Na(+)- and Cl(-)-dependent, high-affinity, low-capacity transporter of taurine and beta-alanine. Human TauT is encoded by the SLC6A6 gene. TauT is expressed in brain, retina, liver, kidney, heart, spleen, and pancreas. It may play a part in the supply of taurine to the intestinal epithelium and in the between-meal-capture of taurine. It may also participate in re-absorbing taurine that has been deconjugated from bile acids in the distal lumen. Functional TauT protects kidney cells from nephrotoxicity caused by the chemotherapeutic agent cisplatin; cisplatin down-regulates TauT in a p53-dependent manner. In mice, TauT has been shown to be important for the maintenance of skeletal muscle function and total exercise capacity. TauT-/- mice develop additional clinically important diseases, some of which are characterized by apoptosis, including vision loss, olfactory dysfunction, and chronic liver disease. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271398  Cd Length: 542  Bit Score: 529.43  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   60 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVW-KICPIL 138
Cdd:cd11510   1 REKWASKIDFLLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGGGLPVFFLEVALGQYTSEGGITCWeKLCPIF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  139 KGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFE 218
Cdd:cd11510  81 TGIGYASIVIVSLLNIYYIVILAWALYYLFQSFQSELPWAHCNQKWNTPCCVEDTLRKNKTLWASINATNFTSPVTEFWE 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  219 RGVLHLhqSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYL 298
Cdd:cd11510 161 RNVLSL--SAGIEHVGTIKWDLALCLLLVWVVCFFCIWKGVKSTGKVVYFTATFPFLMLIVLLIRGVTLPGAAEGIKFYL 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  299 SVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVP 378
Cdd:cd11510 239 YPDITRLGDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNCYRDCLLLGCLNSGTSFVSGFAIFSVLGFMAQEQGVD 318
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  379 IGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHR---HRELFTLFIVLA 455
Cdd:cd11510 319 IADVAESGPGLAFIAYPKAVTMMPLPTFWAILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRkgyRREIFIAIVCFI 398
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  456 TFLLSLFCVTNGGIYVFTLLDHFAA-GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLF 534
Cdd:cd11510 399 SYLLGLTMVTEGGMYVFQLFDYYAAsGVCLLWVAFFECIAVAWVYGGDNMYDAIEDMIGYRPGPWMKYSWIVITPVLCVG 478
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4507041  535 VVVVSIVTFRPPHYG-AYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAP 597
Cdd:cd11510 479 CFIFSLVKYEPLTYNkVYVYPEWAIGLGWVLALSSMICIPMVAVIRIIQTDGPLIERIKALTTP 542
SLC6sbd cd10324
Solute carrier 6 family, neurotransmitter transporters; solute-binding domain; This family ...
61-540 0e+00

Solute carrier 6 family, neurotransmitter transporters; solute-binding domain; This family represents the solute-binding domain of SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family). These use sodium and chloride electrochemical gradients to catalyze the thermodynamically uphill movement of a variety of substrates, and include neurotransmitter transporters (NTTs). The latter are Na+/Cl--dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. NTTs are widely expressed in the mammalian brain, and are involved in regulating neurotransmitter signaling and homeostasis, through facilitating the uptake of released neurotransmitters from the extracellular space into neurons and glial cells. NTTs are the target of a range of therapeutic drugs for the treatment of psychiatric diseases, such as major depression, anxiety disorders, attention deficit hyperactivity disorder and epilepsy. In addition, they are the primary targets of cocaine, amphetamines and other psychostimulants. This family also includes Drosophila Blot which is expressed primarily in epithelial tissues of ectodermal origin and in the nervous system of the embryo and larvae, but in addition found in the developing oocyte and the freshly laid egg. A lack or reduction of Blot function during oogenesis results in early arrest of embryonic development. 12 transmembrane helices (TMs) appears to be common for eukaryotic and some prokaryotic and archaeal SLC6s, (a core inverted topology repeat, TM1-5 and TM6-10, plus TMs11-12; TMs numbered to conform to the SLC6 Aquifex aeolicus LeuT), although a majority of bacterial, and some archaeal SLC6s lack TM12, for example the functional Fusobacterium nucleatum tyrosine transporter Tyt1.


Pssm-ID: 271359 [Multi-domain]  Cd Length: 415  Bit Score: 519.77  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   61 ETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAG-VWKICPILK 139
Cdd:cd10324   1 EQWGSKLEFLLSCIGYAVGLGNIWRFPYLAYENGGGAFLIPYLIMLFLVGIPLFYLELALGQYTSRGPVGaFWRIAPLFK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  140 GVGFTVILISLYVGFFYNVIIAWALHYLFSSFttelpwihcnnswnspncsdahpgdssgdssglndtfgttpaaeyfer 219
Cdd:cd10324  81 GVGYAQVLVSFLVAIYYNVIIAWTLYYLFASF------------------------------------------------ 112
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  220 gvlhlhqshgiddlgpPRWQLTACLVLVIVLLYFSlwKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLS 299
Cdd:cd10324 113 ----------------INWELFLCLLLAWILVYLC--KGVKSIGKGVKFTGPFPYVLLLFLLIRGVTLPGAGDGILFYLT 174
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  300 VDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVPI 379
Cdd:cd10324 175 PDWSKLLDPKVWIAAATQIFFSLGIGFGGLITYASYNKFKNNIYRDALIVAILNTLTSLLAGFVIFSILGFLAHEPGTPV 254
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  380 GDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLL 459
Cdd:cd10324 255 EDVVASGPGLAFIVYPEAIAQMPGPQLWSVLFFLMLFLLGLDSQFAMVEVIVTALADEFPKLRKRRWLVTLGVCVVGFLL 334
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  460 SLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVS 539
Cdd:cd10324 335 GLPYTTPGGIYVLDLFDYYAAGFSLLVIALLELIAIAWIYGVDRFLEDIEFMLGIRPSIYWRICWKFITPVVLLIILVFS 414

                .
gi 4507041  540 I 540
Cdd:cd10324 415 L 415
SLC6sbd_GAT2 cd11507
Na(+)- and Cl(-)-dependent GABA transporter 2; solute-binding domain; This family includes ...
60-600 2.47e-177

Na(+)- and Cl(-)-dependent GABA transporter 2; solute-binding domain; This family includes human GAT2 (hGAT2) which transports gamma-aminobutyric acid (GABA). GABA is the main inhibitory neurotransmitter within the mammalian CNS. hGAT2 is encoded by the SLC6A13 gene, and is similar to mouse GAT-3, and rat GAT2. hGAT2 is expressed in brain, kidney, lung, and testis. hGAT2 is a potential drug target for treatment of epilepsy. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271396  Cd Length: 544  Bit Score: 513.76  E-value: 2.47e-177
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   60 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVW-KICPIL 138
Cdd:cd11507   1 RGQWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLIFLFTCGIPVFFLETALGQYTSQGGVTAWrKICPLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  139 KGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNdtfGTTPAAEYFE 218
Cdd:cd11507  81 EGIGYASQVIVMLLNCYYIIVLAWALFYLFSSFTIDLPWGSCGHEWNTENCMEFQKANSTLNVTSEN---ATSPVIEFWE 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  219 RGVLHLhqSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYL 298
Cdd:cd11507 158 RRVLKI--SDGIQHLGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVSLPGALQGIQFYL 235
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  299 SVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVP 378
Cdd:cd11507 236 YPDLSRLQDPQVWMDAGTQIFFSYAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGTSFVAGFAIFSILGFMAEEQGVP 315
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  379 IGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHR---HRELFTLFIVLA 455
Cdd:cd11507 316 ISEVAESGPGLAFIAYPRAVVMLPFSPLWACFFFFMVVLLGLDSQFVCVESLVTALVDMYPTIFRkknRRELLILAVSIV 395
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  456 TFLLSLFCVTNGGIYVFTLLDHFAA-GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLF 534
Cdd:cd11507 396 SFLVGLIMLTEGGMYVFQLFDYYAAsGMCLLFVAIFETLCVAWVYGADRFYDNIEDMIGYRPWAIIKYCWLFITPAVCMA 475
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4507041  535 VVVVSIVTFRPPHYGA-YIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD 600
Cdd:cd11507 476 TFLFSLIKYTPLTYNKkYVYPWWGDALGWLLALSSMVCIPLWVGYKLSTIKGSLRERFRQLTCPDED 542
SLC6sbd_CT1 cd11509
Na(+)- and Cl(-)-dependent creatine transporter 1; solute-binding domain; CT1 (also called ...
60-590 5.68e-177

Na(+)- and Cl(-)-dependent creatine transporter 1; solute-binding domain; CT1 (also called CRTR, CRT) transports creatine. Human CT1 is encoded by the SLC6A8 gene. CT1 is ubiquitously expressed, with highest levels found in skeletal muscle and kidney. Creatine is absorbed from food or synthesized from arginine and plays an important role in energy metabolism. Deficiency in human CT1 leads to X-linked cerebral creatine transporter deficiency. In males, this disorder is characterized by language and speech delays, autistic-like behavior, seizures in about 50% of cases, and can also involve midfacial hypoplasia, and short stature. In females, it is characterized by mild cognitive impairment with behavior and learning problems. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271397  Cd Length: 589  Bit Score: 514.78  E-value: 5.68e-177
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   60 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILK 139
Cdd:cd11509   1 RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYLLIAFVGGIPIFFLEIALGQFMKAGGINAWNIAPLFK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  140 GVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGT--------- 210
Cdd:cd11509  81 GLGYASMVIVFFCNTYYIMVLAWGFYYLVKSFTNTLPWATCGNPWNTPNCTEIFRHADCNNGASSAGSLANltcdelanr 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  211 -TPAAEYFERGVLHLhqSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPG 289
Cdd:cd11509 161 rSPVIEFWERKVLRL--SGGLEEPGALNWELTLCLLATWVLVYFCVWKGVKSTGKVVYFTATFPYVVLVVLLVRGVTLPG 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  290 AIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLG 369
Cdd:cd11509 239 ALDGIIYYLKPDWSKLGEAQVWIDAGTQIFFSYAIGLGALTALGSYNRFHNNCYKDAFILALINSGTSFFAGFVVFSILG 318
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  370 YMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQ---LLHRHRE 446
Cdd:cd11509 319 FMASEQGVDISKVAESGPGLAFIAYPKAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGILDLLPakyYFRYQRE 398
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  447 LFTLFIVLATFLLSLFCVTNGGIYVFTLLDHF-AAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWK 525
Cdd:cd11509 399 VVVALCCLLCFLIDLSMVTEGGMYVFQLFDYYsASGTTLLWQAFWECVVVAWVYGADRFMDDIARMIGYRPLPWMKWCWS 478
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4507041  526 LVSPCFLLFVVVVSIVTFRPPHYG-AYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREK 590
Cdd:cd11509 479 VITPLVCMGIFLFHVVNYKPLTYNkTYVYPWWGEAIGWCLALSSMLCIPLTVLYKLLRAKGSLKER 544
SLC6sbd-B0AT-like cd10332
System B(0) neutral amino acid transporter AT1, 2 and 3, and related proteins; solute-binding ...
60-579 2.02e-173

System B(0) neutral amino acid transporter AT1, 2 and 3, and related proteins; solute-binding domain; This subgroup includes the solute-binding domain of transmembrane transporters, which transport, i) neutral amino acids: NTT4 (also called XT1), SBAT1 (also called B0AT2, v7-3, NTT7-3), and B0AT1 (also called HND); the human genes encoding these are SLC6A17, SLC6A15, and SLC6A19 respectively, ii) glycine: B0AT3 (also called Xtrp2, XT2), iii) imino acids, such as proline, pipecolate, MeAIB, and sarcosine: SIT1 (also called XTRP3, XT3, IMINO). The human genes encoding B0AT3 and SIT1 are SLC6A18 and SLC6A20 respectively. Transporters in this subgroup may play a role in disorders including major depression, Hartnup disorder, increased susceptibility to myocardial infarction, and iminoglycinuria. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271364  Cd Length: 531  Bit Score: 503.34  E-value: 2.02e-173
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   60 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVW-KICPIL 138
Cdd:cd10332   1 RPAWDNKLQFLLATIGYAVGLGNVWRFPYLCQKNGGGAFLIPYFIMLILEGIPLFFLELAIGQRLRKGSIGVWnTISPYL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  139 KGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHC----NNSWNSPNCSDAhpgdssgdssglndtfgtTPAA 214
Cdd:cd10332  81 GGVGIASVVVSFLVALYYNVIIAWCFFYLFNSFQYPLPWSSCptngNGTGYVEECAKS------------------SPTQ 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  215 EYFERGVLHLhqSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGI 294
Cdd:cd10332 143 YFWYRTTLDI--SPSIDESGGLNWWMTLCLLLAWIIVYLCMMKGIKSSGKVVYFTATFPYIVLIIFFIRGLTLKGAGDGL 220
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  295 RAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQK 374
Cdd:cd10332 221 KHMFTPKFEKLLDPQVWLDAATQIFFSLGLGFGSLIAFSSYNPPKNNCQRDAVLVSLINCFTSIFASIVVFSVLGFKINN 300
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  375 HSVPIG--------------DVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQL 440
Cdd:cd10332 301 VTLTENqtlgltncsledelDEAVQGTGLAFIVFTEAITKMPGAPFWSVLFFLMLLTLGLGSMFGTLEGVVTPLFDSKIL 380
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  441 LHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYW 520
Cdd:cd10332 381 PKVPKEYLTGLVCLVCFLIGLIFTQRSGNYWVQMFDSYAGTLPLLIIALFEMIAVSYVYGLDRFEEDIEYMTGKRPGWYW 460
                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4507041  521 RLCWKLVSPCFLLFVVVVSIVT--FRPPHYGAYI----------FPDWANALGWVIATSSMAMVPIYAAYK 579
Cdd:cd10332 461 KITWRYVSPLLMLVILVASIIQliTKPPTYSAWNaelakteslpYPNWGLAVIILLILLSILPIPGVALLR 531
SLC6sbd_GlyT1 cd11498
Na(+)- and Cl(-)-dependent glycine transporter GlyT1; solute-binding domain; GlyT1 is a ...
56-600 6.67e-169

Na(+)- and Cl(-)-dependent glycine transporter GlyT1; solute-binding domain; GlyT1 is a membrane-bound transporter that re-uptakes glycine from the synaptic cleft. Human GlyT1 is encoded by the SLC6A9 gene. GlyT1 is expressed in brain, pancreas, uterus, stomach, spleen, liver, and retina. GlyT1 may play a role in schizophrenia. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212067  Cd Length: 585  Bit Score: 494.05  E-value: 6.67e-169
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   56 EAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKIC 135
Cdd:cd11498  13 ENLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLVFCGIPLFFMELSFGQFASQGCLGVWRVS 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  136 PILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSS------------G 203
Cdd:cd11498  93 PMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFMSMTRVLPWTYCNNPWNTPDCAGVLSTNRSNATFanmsavvsnlteL 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  204 LNDTFG-TTPAAEYFERGVLHLhqSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLL 282
Cdd:cd11498 173 LNRTLKrTSPSEEYWRRYVLNI--SDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFI 250
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  283 RGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGF 362
Cdd:cd11498 251 RGITLEGAISGIMYYLTPQWDKILDAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSIIISITNCATSVYAGF 330
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  363 VVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEF--QL 440
Cdd:cd11498 331 VIFSILGFMANHLGVDVSEVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAVVDEIgnDW 410
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  441 LHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYW 520
Cdd:cd11498 411 IIRNKTYVTLGVAIIGFLLGIPLTTQAGIYWLLLMDNYAASFSLVIISCIMCIAIMYIYGHRNYFKDIEMMLGFPPPLFF 490
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  521 RLCWKLVSPCFLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGS-FREKLAYAIAPEK 599
Cdd:cd11498 491 QICWRFVSPAIIFFILIFTVIQYRPITYNDYVYPGWAIVIGFLMALSSVICIPIYAIFKICMSEGDtFLERLKNAVKPSK 570

                .
gi 4507041  600 D 600
Cdd:cd11498 571 D 571
SLC6sbd_GAT3 cd11508
Na(+)- and Cl(-)-dependent GABA transporter 3; solute-binding domain; This family includes ...
59-597 4.29e-166

Na(+)- and Cl(-)-dependent GABA transporter 3; solute-binding domain; This family includes human GAT3 (hGAT3) a high-affinity transporter of gamma-aminobutyric acid (GABA). GABA is the main inhibitory neurotransmitter within the mammalian CNS. hGAT3 is encoded by the SLC6A11 gene, and is similar to mouse GAT4, and rat GAT3/GATB. GAT3 is expressed primarily in the glia of the brain, and is a potential drug target for antiepileptic drugs. This subgroup belongs to the solute carrier 6 (SLC6) transporter family


Pssm-ID: 212077  Cd Length: 542  Bit Score: 485.26  E-value: 4.29e-166
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   59 DRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVW-KICPI 137
Cdd:cd11508   1 ERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWrKVCPL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  138 LKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSgDSSGLNDTFGTTPAAEYF 217
Cdd:cd11508  81 FEGIGYATQVIEAHLNVYYIIILAWAIFYLFNCFTTELPWATCGHEWNTENCVEFQKLNSS-NCSHVSLQNATSPVMEFW 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  218 ERGVLHLhqSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAY 297
Cdd:cd11508 160 ERRVLAI--SDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFY 237
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  298 LSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSV 377
Cdd:cd11508 238 LYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGV 317
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  378 PIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHR---HRELFTLFIVL 454
Cdd:cd11508 318 PIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRrgyRRELLILALSI 397
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  455 ATFLLSLFCVTNGGIYVFTLLDHFAA-GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLL 533
Cdd:cd11508 398 VSYFLGLVMLTEGGMYIFQLFDSYAAsGMCLLFVAIFECICIGWVYGSNRFYDNIEDMIGYRPLSLIKWCWMVITPGICA 477
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4507041  534 FVVVVSIVTFRPPHY-GAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAP 597
Cdd:cd11508 478 GIFIFFLVKYKPLKYnNVYTYPDWGYGIGWLMALSSMICIPLWICIKMWKTEGTFPEKLQKLTTP 542
SLC6sbd_ATB0 cd11501
Na(+)- and Cl(-)-dependent beta-alanine transporter ATB0+; solute-binding domain; ATB0+ (also ...
60-600 5.85e-166

Na(+)- and Cl(-)-dependent beta-alanine transporter ATB0+; solute-binding domain; ATB0+ (also known as the beta-alanine carrier) is a transmembrane transporter with a broad substrate specificity; it can transport non-alpha-amino acids such as beta-alanine with low affinity, and can transport dipolar and cationic amino acids such as leucine and lysine, with a higher affinity. It may have a role in the absorption of essential nutrients and drugs in the distal regions of the human gastrointestinal tract. Human ATB0+ is encoded by the SLC6A14 gene. ATB0+ is expressed in the lung, trachea, salivary gland, mammary gland, stomach, and pituitary gland. ATB0+ may play a role in obesity, and its upregulation may have a pathogenic role in colorectal cancer. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271391  Cd Length: 602  Bit Score: 487.08  E-value: 5.85e-166
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   60 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILK 139
Cdd:cd11501   1 RGNWSKKSDYLLSMIGYAVGLGNVWRFPYLTYKNGGGAFLIPYTIMLALAGLPLFFMECSLGQFASLGPISVWRILPLFQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  140 GVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCnNSWNSPNCSD-AHPGDSSGDSSG--------------- 203
Cdd:cd11501  81 GVGITMVLISTFVAIYYNVIIAYSLYYLFASFQSELPWSDC-FSWADENCSKtPIVTHCNVSTANngihenkswvdinnl 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  204 --LNDTF----GTTPAAEYFERgvLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVL 277
Cdd:cd11501 160 tcINGSIiyqpGQLPSEQYWNK--VALQRSSGMDETGVIVWYLALCLLLSWIIVGAALFKGIKSSGKVVYFTALFPYVVL 237
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  278 TALLLRGVTLPGAIDGIRAYLSV--DFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSL 355
Cdd:cd11501 238 LILLVRGATLEGASDGIEYYIGAqsNITKLMEAEVWKDAATQIFYSLSVAWGGLVALSSYNKFHNNCYSDAIVVCVTNCL 317
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  356 TSFSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLI 435
Cdd:cd11501 318 TSVFAGFAIFSVLGHMAHVSGRPVSEVVDSGFDLAFIAYPEALSKLPISPLWSILFFFMLLTLGLDSQFASIETITTTIQ 397
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  436 DEF-QLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQ 514
Cdd:cd11501 398 DAYpKVMKKMRIPITLGVCVILFLLGLVCVTQAGIYWVNLIDHFCAGWGILFAAVLELVGIIWIYGGNRFIEDIEMMIGA 477
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  515 RPS---LYWRLCWKLVSPCFLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKL 591
Cdd:cd11501 478 KSWifwLWWRACWFFITPVLLIAILIWSLVTFHSPTYGSVPYPDWGTALGWCMIIFCLIWIPIVAVIKIIKAKGNLFQRI 557

                ....*....
gi 4507041  592 AYAIAPEKD 600
Cdd:cd11501 558 KSCCRPTSN 566
SLC6sbd_NTT4-like cd11515
Na(+)-dependent neurotransmitter transporter 4, and related proteins; solute-binding domain; ...
60-574 3.06e-129

Na(+)-dependent neurotransmitter transporter 4, and related proteins; solute-binding domain; This subgroup includes the solute-binding domain of NTT4 (also called XT1) and SBAT1 (also called B0AT2, v7-3, NTT7-3); both these proteins can transport neutral amino acids. Human SBAT1 is encoded by the SLC6A15 gene, a susceptibility gene for major depression. SBAT1 is expressed in brain, and may have a role in transporting neurotransmitter precursors into neurons. Human NTT4 is encoded by the SLC6A17 gene. NTT4 is specifically expressed in the nervous system, in synaptic vesicles of glutamatergic and GABAergic neurons, and may play an important role in synaptic transmission. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271400 [Multi-domain]  Cd Length: 530  Bit Score: 390.46  E-value: 3.06e-129
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   60 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWK-ICPIL 138
Cdd:cd11515   1 RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLIVIGIPLFFLELSVGQRIRRGSIGVWNyISPRL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  139 KGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCnnswnspncsdahPGDSSGDSSGLNDTFGTTPAAEYF- 217
Cdd:cd11515  81 GGIGFASCVVCLFVALYYNVIIGWSLFYFSQSFQQPLPWDQC-------------PLVKNASHTFVEPECEKSSATTYYw 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  218 ERGVLHLHQShgIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAY 297
Cdd:cd11515 148 YREALNISDS--ISESGGLNWKMTICLLAAWVIVCLAMIKGIQSSGKIMYFSSLFPYVVLICFLIRALLLNGSVDGIRHM 225
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  298 LSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQK--- 374
Cdd:cd11515 226 FTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKIQKvke 305
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  375 ------HSVPIG-----DVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLlhr 443
Cdd:cd11515 306 eefpalHLNPCLiedelNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGITTPIVDTFKV--- 382
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  444 HRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLC 523
Cdd:cd11515 383 RKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILENIAVAFVYGIDKFMEDLKDMLGFRPYRYYYYM 462
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4507041  524 WKLVSPCFLLFVVVVSIVTF--RPPHYGAYI----------FPDWANALgwVIATSSMAMVPI 574
Cdd:cd11515 463 WKYISPLMLLSLLIASIVNMglSPPGYNAWIedkaserflsYPTWGMVL--CISLIVVAILPI 523
SLC6sbd_B0AT3 cd11517
glycine transporter, B0AT3; solute-binding domain; B0AT3 (also called Xtrp2, XT2) transports ...
59-579 1.27e-121

glycine transporter, B0AT3; solute-binding domain; B0AT3 (also called Xtrp2, XT2) transports glycine. Human B0AT3 is encoded by the SLC6A18 gene. B0AT3 is expressed in the kidney. Mutations in the SLC6A18 gene may contribute to the autosomal recessive disorder iminoglycinuria and its related disorder hyperglycinuria. SLC6A18 or its neighboring genes are associated with increased susceptibility to myocardial infarction. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212086 [Multi-domain]  Cd Length: 576  Bit Score: 372.22  E-value: 1.27e-121
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   59 DRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWK-ICPI 137
Cdd:cd11517   1 ERPKWDNKAQYLLSCIGFAVGLGNIWRFPYLCQTYGGGAFLIPYFIALVFEGIPLFHLELAIGQRLRKGSIGVWTtISPY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  138 LKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSpncsdahpgdssgdsSGLN-DTFGTTPAAEY 216
Cdd:cd11517  81 LGGVGLGCVTVSFLVSLYYNTILAWVLWYFLNSFQHPLPWSSCPLDLNR---------------TGFVeECQGSTAVSYF 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  217 FERGVLHLhqSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRA 296
Cdd:cd11517 146 WYRQTLNI--TPDINDSGSIQWWLLLCLAACWAIVYLCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATEGLIY 223
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  297 YLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMA---- 372
Cdd:cd11517 224 LFTPNMHILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNPPRNDCEKDAVTIALVNSMTSLYASIPVFSVLGFKAtndy 303
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  373 ------------QKHSVPIGDVAKD------------------------------------GPGLIFIIYPEAIATLPLS 404
Cdd:cd11517 304 ehcldrnilsliNEFDFPEQSISRDnypsvlmhlnatwpervaqlplkaclledfldksasGPGLAFIVFTEAVLHMPGA 383
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  405 SAWAVVFFIMLLTLGIDSAMGGMESVITGLIDeFQLLHRH--RELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGT 482
Cdd:cd11517 384 QVWAVLFFGMLFTLGLSSMFGNVEGVITPLLD-VGVLPRWvpKEALTGLVCLVCFLSALCFTLQSGNYWLEIFDSFAASL 462
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  483 SILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPcFLLFVVVVSIVTF---RPPHYGAY-------- 551
Cdd:cd11517 463 NLLVIAFFEVVGVVYVYGIKRFCDDIEWMTGRRPSLYWRLTWRVVSP-LLLLTIFVAYIILlfqKPPSYKAWnpkyelfp 541
                       570       580       590
                ....*....|....*....|....*....|...
gi 4507041  552 -----IFPDWANALGWVIATSSMAMVPIYAAYK 579
Cdd:cd11517 542 sreekLYPGWVQAICVLLSLLPVLWVPVVALAQ 574
SLC6sbd_NTT4 cd11521
Na(+)-dependent neurotransmitter transporter 4; solute-binding domain; NTT4 (also called XT1) ...
60-574 3.76e-117

Na(+)-dependent neurotransmitter transporter 4; solute-binding domain; NTT4 (also called XT1) transports the neutral amino acids, proline, glycine, leucine, and alanine, and may play an important role in synaptic transmission. Human NTT4 is encoded by the SLC6A17 gene. NTT4 is specifically expressed in the nervous system, in synaptic vesicles of glutamatergic and GABAergic neurons. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271403 [Multi-domain]  Cd Length: 589  Bit Score: 361.22  E-value: 3.76e-117
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   60 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWK-ICPIL 138
Cdd:cd11521   1 RPAWNSKLQYILAQIGYSVGLGNVWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELAVGQRIRRGSIGVWNyICPRL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  139 KGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCnnswnspncsdahPGDSSGDSSGLNDTFGTTPAAEYF- 217
Cdd:cd11521  81 GGIGYASCLVCFFVGLYYNVIIGWSIFYFFKSFQYPLPWSEC-------------PVVRNGSVAVVEAECEKSSATTYFw 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  218 ERGVLHLhqSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAY 297
Cdd:cd11521 148 YREALDI--SNSISESGGLNWKMTLCLLVAWSLVGMAMIKGIQSSGKVMYFSSLFPYVVLVCFLVRGLLLRGAVDGILHM 225
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  298 LSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMA----- 372
Cdd:cd11521 226 FTPKLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKAnimne 305
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  373 -------------------------------------------------QKHSVPIG----------DVAKDGPGLIFII 393
Cdd:cd11521 306 kcvvenaekilgylntnvlshdlipphvnfshlttkdynemyrvimtvkEDHFKELGldaclledelDKSVQGTGLAFIA 385
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  394 YPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLlhrHRELFTLFIVLATFLLSLFCVTNGGIYVFT 473
Cdd:cd11521 386 FTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMSGITTPIIDTFKV---RKEVFTVGCCIFAFLVGLIFVQRSGNYFVT 462
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  474 LLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVTF--RPPHYGAY 551
Cdd:cd11521 463 MFDDYSATLPLTVVVILENIAVAWIYGTKKFMQELTEMLGFRPYQFYFYTWKYVSPICMAVLMTASIIQLgvSPPGYSAW 542
                       570       580       590
                ....*....|....*....|....*....|...
gi 4507041  552 I----------FPDWANALgwVIATSSMAMVPI 574
Cdd:cd11521 543 IreeaaekflfYPTWAMAL--LITLIILASLPL 573
SLC6sbd_SBAT1 cd11522
Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain; SBAT1 (also ...
60-574 5.33e-114

Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain; SBAT1 (also called B0AT2, v7-3, NTT7-3) is a high-affinity Na(+)-dependent transporter for large neutral amino acids, including leucine, isoleucine, valine, proline and methionine. Human SBAT1 is encoded by the SLC6A15 gene, a susceptibility gene for major depression. SBAT1 is expressed in brain, and may have a role in transporting neurotransmitter precursors into neurons. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212091 [Multi-domain]  Cd Length: 580  Bit Score: 352.69  E-value: 5.33e-114
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   60 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWK-ICPIL 138
Cdd:cd11522   1 RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLVPYLILLLVIGIPLFFLELSVGQRIRRGSIGVWNyISPKL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  139 KGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHC------NNSWNSPNCSDahpgdssgdssglndtfgTTP 212
Cdd:cd11522  81 GGIGFASCIVCFFVALYYNVIIGWSLFYFSQSFQQPLPWDQCplvknaSHTFVEPECEK------------------SSA 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  213 AAEYFERGVLHLHQShgIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAID 292
Cdd:cd11522 143 TTYYWYREALNISSS--ISESGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIMYFSSLFPYVVLICFLIRALLLNGSVD 220
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  293 GIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMA 372
Cdd:cd11522 221 GIRHMFTPKLEIMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKA 300
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  373 Q----------------------------KHSVPIGDV------------------------------------AKDGPG 388
Cdd:cd11522 301 NvinekciiqnsekiikllkmgnlsqdiiPHHINFSSItaedynlvydiiqkvkeeefpalglkscqiedelnkAVQGTG 380
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  389 LIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLlhrHRELFTLFIVLATFLLSLFCVTNGG 468
Cdd:cd11522 381 LAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGIITPIVDTFKV---RKEILTVICCLLAFCIGLIFVQRSG 457
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  469 IYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVT--FRPP 546
Cdd:cd11522 458 NYFVTMFDDYSATLPLLIVVILENIAVSFVYGIDKFMEDLKDMLGFTPNRYYYYMWKYISPLVLLSLLVASVVQmgLSPP 537
                       570       580       590       600
                ....*....|....*....|....*....|....*....|
gi 4507041  547 HYGAYI----------FPDWanalGWVIATSSM--AMVPI 574
Cdd:cd11522 538 GYNAWIedkateeflsYPTW----GLVVCISLVvlAILPV 573
SLC6sbd_SIT1 cd11518
Na(+)- and Cl(-)-dependent imino acid transporter SIT1; solute-binding domain; SIT1 (also ...
60-584 8.08e-114

Na(+)- and Cl(-)-dependent imino acid transporter SIT1; solute-binding domain; SIT1 (also called XTRP3, XT3, IMINO) transports imino acids, such as proline, pipecolate, MeAIB, and sarcosine. It has weak affinity for neutral amino acids such as phenylalanine. Human SIT1 is encoded by the SLC6A20 gene. SIT1 is expressed in brain, kidney, small intestine, thymus, spleen, ovary, and lung. SLC6A20 is a candidate gene for the rare disorder iminoglycinuria. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271401 [Multi-domain]  Cd Length: 576  Bit Score: 351.95  E-value: 8.08e-114
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   60 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWK-ICPIL 138
Cdd:cd11518   4 RPLWDNPLQFVFACISYAVGLGNVWRFPYLCQMYGGGGFLIPYLIMLILEGMPLLYLELAVGQLMRQGSIGAWKsISPYL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  139 KGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCnnswnspncsdahpgDSSGDSSGLNDTFGTTPAAEYF- 217
Cdd:cd11518  84 GGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSNC---------------PLNSNHTAYNEECEKASPTQYFw 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  218 ERGVLHLHQShgIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAY 297
Cdd:cd11518 149 YRKTLNISPS--ILENGGIQWELAVCLILAWLVVYLCILRGTESTGKVVYVTALIPYLVLLIYLIRGLTLHGAANGLAYM 226
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  298 LSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMA----- 372
Cdd:cd11518 227 FTPKLEQLANPKTWINAATQIFFSLGLGFGSLIAFASYNEPSNNCERHAIIVSLINSGTSIFASIVTFSIYGFKAtfnye 306
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  373 --------------------------------------QKHS--VPI---------GDVAKDGPGLIFIIYPEAIATLPL 403
Cdd:cd11518 307 ncmkkvillltntfdleegsvttenlgdmknylasafpQEYSsiVPQikncslekeLDTAVQGTGLAFIVYTEAIKNMEV 386
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  404 SSAWAVVFFIMLLTLGIDSAMGGMESVITGLID-EFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGT 482
Cdd:cd11518 387 SQLWSVLYFLMLLMLGIGSMLGNTAAILTPLTDsKFISSHLPKEAISGLLCFTNCIIGLVFTMEAGNYWFDIFNDYAATL 466
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  483 SILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPcfllfVVVVSIVTFRPPHY---GAYIFPDWANA 559
Cdd:cd11518 467 SLLLIVLVETIAVCYVYGLRRFENDLEAMTGHKLSWYWKIMWAFVSP-----LLIVSLFIFYLTDYimtGTLQYQAWDAT 541
                       570       580
                ....*....|....*....|....*....
gi 4507041  560 LGWVIA----TSSMAMVPIYAAYKFCSLP 584
Cdd:cd11518 542 LGQLVTkdypPYALAVIGLLVAASTCCIP 570
SLC6sbd_B0AT1 cd11516
Na(+)-dependent neutral amino acids transporter, B0AT1; solute-binding domain; B0AT1 (also ...
60-579 1.02e-112

Na(+)-dependent neutral amino acids transporter, B0AT1; solute-binding domain; B0AT1 (also called HND) transports neutral amino acids. Human B0AT1 is encoded by the SLC6A19 gene. B0AT1 is expressed primarily in the kidney and intestine; it requires collectrin for expression in the kidney, and angiotensin-converting enzyme 2 for expression in the intestine. Interaction with these two proteins implicates B0AT1 in more complex processes such as glomerular structure, exocytosis, and blood pressure control. The autosomal recessive disorder, Hartnup disorder, is caused by mutations in B0AT1. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212085 [Multi-domain]  Cd Length: 581  Bit Score: 349.19  E-value: 1.02e-112
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   60 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWK-ICPIL 138
Cdd:cd11516   1 RPKWDNKAQYMLTCVGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVFEGIPLLHLEFAIGQRLRKGSVGVWStIHPTL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  139 KGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHC----NNSWNSPNCSDAHPGDSsgdssglndtfgttpaa 214
Cdd:cd11516  81 KGVGIASMCVSFLVSLYYNTIIAWVMWYFFNSFQEPLPWSQCplneNRTGYIPECAKSSPVDY----------------- 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  215 eYFERGVLHLhqSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGI 294
Cdd:cd11516 144 -FWYRETLNT--STSIDDSGGIQWWMVLCLACAWGVLYVCTIRGIETTGKAVYVTSTLPYLVLTIFLIRGLTLKGSVNGI 220
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  295 RAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQK 374
Cdd:cd11516 221 KFLFTPDINELANPVTWLDAGAQVFYSFSLAFGGLISFSSYNSVHNNCEKDAVIISVINGFTSIYAATVIYSIIGFRATE 300
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  375 H----------------SVPIGDVAKD------------------------------------GPGLIFIIYPEAIATLP 402
Cdd:cd11516 301 RfddcfdgniltlinafDLPEGNITQDnyqdmqqslnstdpdiisslslqtcdlnnflsegveGTGLAFIVFTEAITKMP 380
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  403 LSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDeFQLLHRH--RELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAA 480
Cdd:cd11516 381 LSPLWSVLFFIMLFCLGLSSMFGNMEGVLVPLQD-LKVIPKSwpKEIITGLICLVSFLIGLIFVLGSGNYWLALFDSFAG 459
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  481 GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLL------FVVVVS----IVTFRP----- 545
Cdd:cd11516 460 SIPLLIIAFCEMFSVVYVYGIDRFNKDIEFMIGHKPNIFWQATWRVISPLIMLviflfyFVVKVSqelfYSAWDPeyeef 539
                       570       580       590
                ....*....|....*....|....*....|....
gi 4507041  546 PHYGAYIFPDWANALGWVIATSSMAMVPIYAAYK 579
Cdd:cd11516 540 PKSQKISYPTWIYVIIVILAGVPSLAIPGYAIYK 573
SLC6sbd_u1 cd10334
uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; SLC6 ...
60-565 3.64e-111

uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family) include neurotransmitter transporters (NTTs): these are sodium- and chloride-dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. These NTTs are widely expressed in the mammalian brain, involved in regulating neurotransmitter signaling and homeostasis, and the target of a range of therapeutic drugs for the treatment of psychiatric diseases. Bacterial members of the SLC6 family include the LeuT amino acid transporter.


Pssm-ID: 271366 [Multi-domain]  Cd Length: 480  Bit Score: 341.78  E-value: 3.64e-111
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   60 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVW-KICPIL 138
Cdd:cd10334   1 REQWGSRAGFILAAIGSAVGLGNIWRFPYVAYENGGGAFLIPYLIALLTAGIPLLILEYGLGHKYRGSAPLAFrRLNKKF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  139 KGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTelpwihcnnSWnspncsdahpgdssgdssglndtfGTTPAAEYFE 218
Cdd:cd10334  81 EWIGWWQVLVAFVIATYYAVIIAWALSYLFFSFTL---------AW------------------------GDDPEAFFFG 127
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  219 RgvlHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTS-GKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAY 297
Cdd:cd10334 128 D---FLQLSDSPFDLGGIVWPILIALVLVWLIIWFILYRGVKKGiEKASKIFMPLLFVLFLILVIRALTLPGAADGLNAL 204
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  298 LSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSV 377
Cdd:cd10334 205 FTPDWSALLDPKVWIAAYGQIFFSLSLGFGIMITYASYLPKKSDLTNNALITAFANSGFEILAGIGVFSILGFMAQAQGV 284
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  378 PIGDVAKDGPGLIFIIYPEAIATL-PLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLlhrHRELFTLFIVLAT 456
Cdd:cd10334 285 PVSEVVSSGIGLAFVAFPKAINLMpPLGALFGVLFFLSLVFAGLTSLISLVEVVISAVQDKFGL---SRKKAVTIVCLVG 361
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  457 FLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVV 536
Cdd:cd10334 362 FLVSLLFATGAGLYLLDIVDHFINNYGIVLVGLVEVIVVGWVFGAEKLREHLNAVSDFKVGKWWDFLIKVVTPLVLGYML 441
                       490       500       510
                ....*....|....*....|....*....|
gi 4507041  537 VVSIVT-FRPPhYGAYIfPDWANALGWVIA 565
Cdd:cd10334 442 ILGLIGlLTEP-YGGYP-VWALLLFGWGIV 469
SLC6sbd_NTT5 cd11502
Neurotransmitter transporter 5; solute-binding domain; Human NTT5 is encoded by the SLC6A16 ...
60-573 1.06e-97

Neurotransmitter transporter 5; solute-binding domain; Human NTT5 is encoded by the SLC6A16 gene. NTT5 is expressed in testis, pancreas, and prostate; its expression is predominantly intracellular, indicative of a vesicular location. Its substrates are unknown. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271392  Cd Length: 535  Bit Score: 308.98  E-value: 1.06e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   60 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWK-ICPIL 138
Cdd:cd11502   1 RPLWSKKTEYILAQVGFSVGLSSIWRFPYLWHHNGGGSFLLIYILMLFLVGIPLLFLEMAVGQRLRQGSIGVWKiLSPWL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  139 KGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSpncsdahpgdSSGDSSGLNdtfgTTPAAEYFE 218
Cdd:cd11502  81 GGVGYSSFLVCFIVGLYNNVLNSWSLFYLSQSFQFPLPWEKCPLVKNS----------SDFDPECAR----TTPSQYFWY 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  219 RGVLHlhQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYL 298
Cdd:cd11502 147 RQTLK--ASDRIEDGGVLVLSLTLSLFLAWCLLCVFMINGLKSTGKMLYVLVLLPYIILLCFLIRTLFLEGAKFGLKHLL 224
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  299 SVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQK---- 374
Cdd:cd11502 225 VAKVSALYSLSVWRQAGGQVLYSLGLGFGTIISFSSYMPRSNNCLKDAFLVALVNLVTSLLTTPFIFAVLGFWATPasiy 304
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  375 ----------------HSVPIGDV------AKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVIT 432
Cdd:cd11502 305 lswlnnlpqhiksqvlSKVPECSIqkqkekIMEGPGFAFLAFSEAISLFPGSSFWSILFFLMLLILGLSTMLGIMQGIIT 384
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  433 GLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMT 512
Cdd:cd11502 385 PLQDTFSFFRKHPKLLTVGVCLLMFLCSLIFTRPSGSYYVSLLDDYWVPMPIIFIVICENLAVAWAYGAKRFLADLMILL 464
                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4507041  513 GQRPSLYWRLCWKLVSPCFLLFVVVVSIVTF--RPPHYGAY----------IFPDWanALGWVIATSSMAMVP 573
Cdd:cd11502 465 GHPISPIFTWLWCYLTPVVLLVLFTITLIQLyvKPITYLAWdsstshevtrPYPSW--ALGLVIFLSVIVLLP 535
YocR COG0733
Na+-dependent transporter, SNF family [General function prediction only];
56-540 6.16e-92

Na+-dependent transporter, SNF family [General function prediction only];


Pssm-ID: 440497 [Multi-domain]  Cd Length: 444  Bit Score: 290.85  E-value: 6.16e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   56 EAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKIC 135
Cdd:COG0733   1 ASSKREQWSSRLGFILAAAGSAVGLGNIWRFPYVAGENGGGAFLLPYLLALLLIGIPLLIAEFAIGRRGRKSPVGAFRKL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  136 ---PILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPwihcnnswnspncsdahpGDSSGDSSGLNDTFGTTP 212
Cdd:COG0733  81 apgKKWEWIGWLGVLGAFLILSYYSVVAGWVLAYLFKSLTGAFG------------------GLDAEDAGAFFGAFLSSP 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  213 aaeyfergvlhlhqshgiddlgpprWQLTACLVLVIVLLYFSLWKGVKTS-GKVVWITatMP--YVVLTALLLRGVTLPG 289
Cdd:COG0733 143 -------------------------GEVLIWHLLFLLLTALIVARGVQKGiEKASKIL--MPllFVLLIILVIRALTLPG 195
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  290 AIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLg 369
Cdd:COG0733 196 AAEGLKFLFTPDFSKLTDPEVWLAALGQAFFSLSLGMGIMITYGSYLPKDEDLPRSALIVALLDTLVALLAGLAIFPAV- 274
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  370 YMAqkhsvpiGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLlhrHRELFT 449
Cdd:COG0733 275 FAF-------GLEPAAGPGLAFVTLPAVFAQMPGGRLFGVLFFLLLLFAALTSAISLLEVVVAALIDKFGL---SRKKAT 344
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  450 LFIVLATFLLSLFCVTNG------GIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLC 523
Cdd:COG0733 345 LIVGLLIFLLGIPSALSFnvsvtiGLTFFDLVDFLVSNILLPLGGLLIAIFVGWVLGKEKLREELNAGSDIKLGKWWRFL 424
                       490
                ....*....|....*..
gi 4507041  524 WKLVSPCFLLFVVVVSI 540
Cdd:COG0733 425 IRYVAPVALLIIFLNGL 441
SLC6sbd_u2 cd11554
uncharacterized eukaryotic solute carrier 6 subfamily; solute-binding domain; SLC6 proteins ...
63-510 3.17e-85

uncharacterized eukaryotic solute carrier 6 subfamily; solute-binding domain; SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family) include neurotransmitter transporters (NTTs): these are sodium- and chloride-dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. These NTTs are widely expressed in the mammalian brain, and are involved in regulating neurotransmitter signaling and homeostasis, and are the target of a range of therapeutic drugs for the treatment of psychiatric diseases. Bacterial members of the SLC6 family include the LeuT amino acid transporter.


Pssm-ID: 212092 [Multi-domain]  Cd Length: 406  Bit Score: 272.27  E-value: 3.17e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   63 WGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVW-KICPILKGV 141
Cdd:cd11554   3 WGSRTAFVLAAMGGAVGLGNLLRFPSVVYNNGGLQFFIPYLLALVLLAIPILILELALGQAYRGGCVKAFnLINRRAKGV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  142 GFTVILISLYVGFFYNVIIAWALHYLFSSFTTelpwihcnnSWnspncsdahpgdssgdssglndtfgttpaaeyfergv 221
Cdd:cd11554  83 GAAVVFGGFVVCTYYVPILAWIMVYFRHSFTV---------GW------------------------------------- 116
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  222 lhlhqshgiddlgpprwqltacLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSVD 301
Cdd:cd11554 117 ----------------------LAFTWFVVWLCVFRGVGSTGRVVYITMGLPIVLIIILLGRGASLPNAGDGIRLYFATW 174
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  302 FY-RLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAqkHSVPIG 380
Cdd:cd11554 175 RGdKLASGEIWQAAAGQVFFSTGVGFGYMTAYASYNSKFSNAVQDALIIAGSNSLFEIIAGFAVFGIVGYLG--MTPGVE 252
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  381 DVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLS 460
Cdd:cd11554 253 GEALGGFVLGFVTYPEAIAQMPGSNFFAVLFFLTLFLLGISSAFALLEAVVTLICDSGWGRKVKRWWIATVVCFVSFLLS 332
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|
gi 4507041  461 LFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGvgqFSDDIQQ 510
Cdd:cd11554 333 LPYCTRFGYYLLDAVDAWISNVALVFVVWAECVAATTVYR---FEDVVDQ 379
SLC6sbd_Tyt1-Like cd10336
solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; SLC6 ...
61-540 8.50e-68

solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family) include neurotransmitter transporters (NTTs): these are sodium- and chloride-dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. These NTTs are widely expressed in the mammalian brain, involved in regulating neurotransmitter signaling and homeostasis, and the target of a range of therapeutic drugs for the treatment of psychiatric diseases. Bacterial members of the SLC6 family include the LeuT amino acid transporter. An arrangement of 12 transmembrane (TM) helices appears to be as a common topological motif for eukaryotic and some prokaryotic and archaeal NTTs. However, this subfamily which contains the majority of bacterial members and some archaeal members, appears to contain only 11 TMs; for example the functional Fusobacterium nucleatum tyrosine transporter Tyt1.


Pssm-ID: 271367 [Multi-domain]  Cd Length: 440  Bit Score: 227.32  E-value: 8.50e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   61 ETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKIC----P 136
Cdd:cd10336   1 EQWSSRLGFILAAAGSAVGLGNIWRFPYLAGENGGGAFLLVYLLFVLLIGLPLLIAEFAIGRRTRKNPVGAFAKLagggK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  137 ILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELpwihcnnswnspncsdahpgdSSGDSSGLNDTFGTTPAAEy 216
Cdd:cd10336  81 KWKLIGWLGVLGGFLILSFYSVVGGWVLKYLFKSLTGLF---------------------AGADAAEVGAAFFGFIASP- 138
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  217 fergvlhlhqshgiddlgpprWQLTACLVLVIVLLYFSLWKGVKtSG--KVVWITatMP--YVVLTALLLRGVTLPGAID 292
Cdd:cd10336 139 ---------------------LSPLLWHLLFLLLTALIVARGVK-KGieRANKIL--MPllFILLIILAIRSLTLPGAGE 194
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  293 GIRAYLSVDFYRLcEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFL-GYM 371
Cdd:cd10336 195 GLKFLLKPDFSKL-TPEVVLAALGQAFFSLSLGMGVMITYGSYLSKDENLPKSALIVAVLDTLVALLAGLVIFPAVfAFG 273
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  372 AQKHSvpigdvakdGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFqllHRHRELFTLF 451
Cdd:cd10336 274 LDPAA---------GPGLLFITLPAVFAQMPGGRLFGILFFLLLLFAALTSAISLLEVVVAYLIDEF---GWSRKKATLI 341
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  452 IVLATFLLSLFCV---------TNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRP-SLYWR 521
Cdd:cd10336 342 VGIIIFLLGIPSAlsfgvlsdvTIFGKTFFDLLDFLVSNILLPLGGLLIAIFVGWVLGKEALLEELNKGGLGKKlFKIWL 421
                       490
                ....*....|....*....
gi 4507041  522 LCWKLVSPCFLLFVVVVSI 540
Cdd:cd10336 422 FLLRYVAPVAILIIFLLGL 440
LeuT-like_sbd cd10333
Aquifex aeolicus LeuT and related proteins; solute binding domain; LeuT is a bacterial amino ...
60-579 6.53e-47

Aquifex aeolicus LeuT and related proteins; solute binding domain; LeuT is a bacterial amino acid transporter with specificity for the hydrophobic amino acids glycine, alanine, methionine, and leucine. This subgroup belongs to the solute carrier 6 (SLC6) transporter family; LeuT has been used as a structural template for understanding fundamental aspects of SLC6 function. It has an arrangement of 12 transmembrane helices (TMs), which appears to be a common motif for eukaryotic and some prokaryotic and archaeal SLC6s: an inverted topology repeat: TMs1-5 and TMs6-10, and TMs11-12.


Pssm-ID: 271365 [Multi-domain]  Cd Length: 496  Bit Score: 172.50  E-value: 6.53e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   60 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNreGAAG--------- 130
Cdd:cd10333   1 REHWGSRIGLILAMAGNAVGLGNFLRFPVQAAQNGGGAFMIPYFIAFLLLGIPLMWIEWAMGRYG--GKYGhgttpmifl 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  131 VWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPwihcnnswnspncsdaHPGDSSGdssglndtfgt 210
Cdd:cd10333  79 LAWENRFAKILGAIGLAIPLLVNSYYVYIESWTLGYAFKSLTGAYP----------------EPPSILR----------- 131
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  211 tPAAEYFergVLHLHQSHGiddlgPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVwitatMP--YVVLTALLLRGVTLP 288
Cdd:cd10333 132 -PTAEFF---YSYIGKPSG-----LAYIFFLITMALNFFILYRGVSKGIEAFAKIA-----MPllYVFAIILLIRVLTLG 197
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  289 -------GAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSG 361
Cdd:cd10333 198 spvnpnwTALKGLNFLWNPDFSKLKNPKVWLAAAGQIFFTLSLGMGIIQNYASYLKKDDDVVLSGLTAASLNEFAEVILG 277
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  362 F-----VVFSFLGYMAQkhsvpigDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLID 436
Cdd:cd10333 278 GsiaipAAFAFLGVAVA-------IAKAGGFGLGFIALPNVFSQMPGGQFFGFLWFLLLFFAGITSSIAMYQPLIAFLEE 350
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  437 EFQLLHRHRELFTLFIVlatFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRP 516
Cdd:cd10333 351 ELGISRKHAAWVVFAIV---FFLGLPVVLEFDLKALDELDFWVGTILLVILGLIEIIVFGWIFGAKKGWEEINRGALIKV 427
                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4507041  517 SLYWRLCWKLVSPCFLLFVVVVSIVTFRPPHYGAYIFPDWAN-ALGWVIATSSMAMVPIYAAYK 579
Cdd:cd10333 428 PRFYKYVMKYITPAFLAVVLVFWTISYIPKGYFKMNLIPTVWiARFVIIGLFLFLAFLVYLAIK 491
SLC5-6-like_sbd cd06857
Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the ...
67-543 5.19e-39

Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporters or solute sodium symporters), SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporters or Na+/Cl--dependent transporters), and nucleobase-cation-symport-1 (NCS1) transporters. SLC5s co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. SLC6s include Na+/Cl--dependent plasma membrane transporters for the monoamine neurotransmitters serotonin, dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. Members of this superfamily are important in human physiology and disease. They contain a functional core of 10 transmembrane helices (TMs): an inverted structural repeat, TMs1-5 and TMs6-10; TMs numbered to conform to the SLC6 Aquifex aeolicus LeuT.


Pssm-ID: 271356 [Multi-domain]  Cd Length: 407  Bit Score: 148.27  E-value: 5.19e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   67 IDFLLSVIGFAVDLANVWRFPYLCYKNGGGaFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILKGVGFTVI 146
Cdd:cd06857   1 FDLILACIGLALGLANFIRFPQMTYSYGGA-FILPYIVLSIIVGIPLLVLELSMGQFSGIGFISMWRCSPFFKGLGVVSL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  147 LISLYVGFFYNVIIAWALHYLfssfttelpwIHCNNswnspncsdahpgdssgdssglndtfgttpaaeyfergvlhlhq 226
Cdd:cd06857  80 FLSFLLLIYYTYLAALALVYI----------INLYY-------------------------------------------- 105
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  227 shgiddlgpprWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLP--GAIDGIRAYLSVDFYR 304
Cdd:cd06857 106 -----------WILALGLFLIWVTIYGIFFRGLKSIGKLIVIAVIVLLVLLLVLTVRALFLEgaGASEGLNKGGTPDFME 174
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  305 LCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQ--KHSVPIGDV 382
Cdd:cd06857 175 LNNSGIWTAATIQVFFSLGAGWGSVITIASFCLFKKNAQRDALIAAFLNLIASIIFVGLIGIAAGVLSFdpQNMVVLGLL 254
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  383 AKDgpGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLF 462
Cdd:cd06857 255 NSL--YLTFIASPQAISSLAGSNLWAFLYYAALLLAGLSSMATITNTVAQSLFDEFRRKLKTGVIDTALIVVLLVAAVIF 332
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041  463 CVTNGGIyvFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWrlcWKLVSPCfLLFVVVVSIVT 542
Cdd:cd06857 333 LVLGLRI--LFLTDKQLVGTSVVPLLLILLLVVFWIYGRERIQRDIEFMLGPVGSIVW---FWLWVIA-PAILVIILVWA 406

                .
gi 4507041  543 F 543
Cdd:cd06857 407 A 407
Na_transp NF037979
sodium-dependent transporter;
65-495 3.36e-04

sodium-dependent transporter;


Pssm-ID: 468298 [Multi-domain]  Cd Length: 417  Bit Score: 43.38  E-value: 3.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041    65 KKIDFLLS--VIGFAVDLANVWRFPYLCYKNGGGAFLVpYLLFMVIA-GMPLFYMELALGQ-------FNREGAAGVWKI 134
Cdd:NF037979   1 RKWTLYLIflVAGYAVGIGTFWLFPQFWLQYGLTGLVV-YLIFLAVLtYLAILEAESTKKSryyivelYTKVARTPAMIL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   135 cpilkgVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPwihcnnswnspncsdahpgdssgdssglndtfgttpaa 214
Cdd:NF037979  80 ------VLLMFLVIFLGVISYYTANGGLLLSPILGTGTLGIL-------------------------------------- 115
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   215 eyfergvlhlhqshgiddlgpprwqLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGi 294
Cdd:NF037979 116 -------------------------IAKLLMILLAFLILTRAKEKTLDIMAIGSVLFVIFVVVSAILFRSQVLSVAPQA- 169
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   295 RAYLSVDFYRLCE-----ASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLG 369
Cdd:NF037979 170 AQYLSMAKSMIFSfhpitLKLVVDMALQAIYSLGLGFGFYLVLGSFLPERFNAKKIIGIGILLQTLLSFLATFTVVYSLG 249
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507041   370 YMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQlLHRHRELFT 449
Cdd:NF037979 250 PAHPGYLTAFVYGGEEEAISLFYSLPLILRDVPGGPTLLYLLMLSLFLAGLTSILPLGEVGGQIISEVFQ-LGRNKALIY 328
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 4507041   450 LFIVlaTFLLSLFCVTNGGIYVFTLldhfAAGTSILFGVLIEAIGV 495
Cdd:NF037979 329 VLGI--SLVLGGIDSLPSIATMLLK----AVSVFIFFTAIVEAYPL 368
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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