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Conserved domains on  [gi|89886486|ref|NP_001034967|]
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striatin-4 isoform 2 [Mus musculus]

Protein Classification

striatin( domain architecture ID 10548818)

striatin, a WD40 repeat protein which may function as scaffolding or signaling protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 430-752 2.76e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 199.48  E-value: 2.76e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486 430 PKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQkavtakknaalDVEPIHAFRAHRGPVLAVTMGSNSEYCYSG 509
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASG 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486 510 GADARIHSWKIPDLNmdpydgydpsvLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDpsssGPSCLCTFPMDGE 589
Cdd:cd00200  70 SSDKTIRLWDLETGE-----------CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD----VETGKCLTTLRGH 134

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486 590 HGIPTSVAFTSTEpaHVVASFRSGDTV-LYDLEAGSALLTLEsrGSSGPaqINQVVSHPSQPLTITAHDDRGIRFLDNRT 668
Cdd:cd00200 135 TDWVNSVAFSPDG--TFVASSSQDGTIkLWDLRTGKCVATLT--GHTGE--VNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486 669 GKSVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLWSLDNKTCVQEITAhrkkHEEAIHAVACHPSKALIASAGADAL 748
Cdd:cd00200 209 GKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG----HTNSVTSLAWSPDGKRLASGSADGT 284


                ....
gi 89886486 749 AKVF 752
Cdd:cd00200 285 IRIW 288
Striatin pfam08232
Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a ...
 65-189 3.70e-40

Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (pfam00400) repeat domain. It acts as a scaffold protein and is involved in signalling pathways.


:

Pssm-ID: 462401  Cd Length: 85  Bit Score: 142.26  E-value: 3.70e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486    65 LPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERakyhklkfgtdlnqg 144
Cdd:pfam08232   1 LPGVLHFLQTEWHRHERDRNAWEIERAEMKARIAKLEGERRGQENLKKDLKRRIKMLEYALKQES--------------- 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 89886486   145 ekktdlseqvsngpvesvtlensplVWKEGRQLLRQYLEEVGYTD 189
Cdd:pfam08232  66 -------------------------KRKKSRQYLKKCLQEIGYLD 85
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 430-752 2.76e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 199.48  E-value: 2.76e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486 430 PKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQkavtakknaalDVEPIHAFRAHRGPVLAVTMGSNSEYCYSG 509
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASG 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486 510 GADARIHSWKIPDLNmdpydgydpsvLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDpsssGPSCLCTFPMDGE 589
Cdd:cd00200  70 SSDKTIRLWDLETGE-----------CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD----VETGKCLTTLRGH 134

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486 590 HGIPTSVAFTSTEpaHVVASFRSGDTV-LYDLEAGSALLTLEsrGSSGPaqINQVVSHPSQPLTITAHDDRGIRFLDNRT 668
Cdd:cd00200 135 TDWVNSVAFSPDG--TFVASSSQDGTIkLWDLRTGKCVATLT--GHTGE--VNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486 669 GKSVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLWSLDNKTCVQEITAhrkkHEEAIHAVACHPSKALIASAGADAL 748
Cdd:cd00200 209 GKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG----HTNSVTSLAWSPDGKRLASGSADGT 284


                ....
gi 89886486 749 AKVF 752
Cdd:cd00200 285 IRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
426-751 2.53e-56

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 198.21  E-value: 2.53e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486 426 KTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAvtakknaaldvEPIHAFRAHRGPVLAVTMGSNSEY 505
Cdd:COG2319 108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG-----------KLLRTLTGHSGAVTSVAFSPDGKL 176

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486 506 CYSGGADARIHSWKIPDLNmdpydgydpsvLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSssGPSCLCTFP 585
Cdd:COG2319 177 LASGSDDGTVRLWDLATGK-----------LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA--TGKLLRTLT 243

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486 586 mdGEHGIPTSVAFtSTEPAHVVASFRSGDTVLYDLEAGSALLTLESRGSSgpaqINQVVSHPSQPLTITAHDDRGIRFLD 665
Cdd:COG2319 244 --GHSGSVRSVAF-SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG----VNSVAFSPDGKLLASGSDDGTVRLWD 316

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486 666 NRTGKSVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLWSLDNKTCVQEITAhrkkHEEAIHAVACHPSKALIASAGA 745
Cdd:COG2319 317 LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG----HTGAVTSVAFSPDGRTLASGSA 392


                ....*.
gi 89886486 746 DALAKV 751
Cdd:COG2319 393 DGTVRL 398
Striatin pfam08232
Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a ...
 65-189 3.70e-40

Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (pfam00400) repeat domain. It acts as a scaffold protein and is involved in signalling pathways.


Pssm-ID: 462401  Cd Length: 85  Bit Score: 142.26  E-value: 3.70e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486    65 LPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERakyhklkfgtdlnqg 144
Cdd:pfam08232   1 LPGVLHFLQTEWHRHERDRNAWEIERAEMKARIAKLEGERRGQENLKKDLKRRIKMLEYALKQES--------------- 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 89886486   145 ekktdlseqvsngpvesvtlensplVWKEGRQLLRQYLEEVGYTD 189
Cdd:pfam08232  66 -------------------------KRKKSRQYLKKCLQEIGYLD 85
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 533-572 1.33e-11

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 59.63  E-value: 1.33e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 89886486    533 PSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWD 572
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
538-572 1.45e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 56.58  E-value: 1.45e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 89886486   538 HVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWD 572
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 430-752 2.76e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 199.48  E-value: 2.76e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486 430 PKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQkavtakknaalDVEPIHAFRAHRGPVLAVTMGSNSEYCYSG 509
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASG 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486 510 GADARIHSWKIPDLNmdpydgydpsvLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDpsssGPSCLCTFPMDGE 589
Cdd:cd00200  70 SSDKTIRLWDLETGE-----------CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD----VETGKCLTTLRGH 134

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486 590 HGIPTSVAFTSTEpaHVVASFRSGDTV-LYDLEAGSALLTLEsrGSSGPaqINQVVSHPSQPLTITAHDDRGIRFLDNRT 668
Cdd:cd00200 135 TDWVNSVAFSPDG--TFVASSSQDGTIkLWDLRTGKCVATLT--GHTGE--VNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486 669 GKSVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLWSLDNKTCVQEITAhrkkHEEAIHAVACHPSKALIASAGADAL 748
Cdd:cd00200 209 GKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG----HTNSVTSLAWSPDGKRLASGSADGT 284


                ....
gi 89886486 749 AKVF 752
Cdd:cd00200 285 IRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
426-751 2.53e-56

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 198.21  E-value: 2.53e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486 426 KTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAvtakknaaldvEPIHAFRAHRGPVLAVTMGSNSEY 505
Cdd:COG2319 108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG-----------KLLRTLTGHSGAVTSVAFSPDGKL 176

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486 506 CYSGGADARIHSWKIPDLNmdpydgydpsvLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSssGPSCLCTFP 585
Cdd:COG2319 177 LASGSDDGTVRLWDLATGK-----------LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA--TGKLLRTLT 243

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486 586 mdGEHGIPTSVAFtSTEPAHVVASFRSGDTVLYDLEAGSALLTLESRGSSgpaqINQVVSHPSQPLTITAHDDRGIRFLD 665
Cdd:COG2319 244 --GHSGSVRSVAF-SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG----VNSVAFSPDGKLLASGSDDGTVRLWD 316

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486 666 NRTGKSVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLWSLDNKTCVQEITAhrkkHEEAIHAVACHPSKALIASAGA 745
Cdd:COG2319 317 LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG----HTGAVTSVAFSPDGRTLASGSA 392


                ....*.
gi 89886486 746 DALAKV 751
Cdd:COG2319 393 DGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 417-707 7.03e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 168.28  E-value: 7.03e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486 417 LSDSKDAFKKTWN-----PKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKavtakknaaldVEPIHAFRAHR 491
Cdd:cd00200  25 ATGSGDGTIKVWDletgeLLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET-----------GECVRTLTGHT 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486 492 GPVLAVTMGSNSEYCYSGGADARIHSWKIPDlnmdpydgydpSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIW 571
Cdd:cd00200  94 SYVSSVAFSPDGRILSSSSRDKTIKVWDVET-----------GKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486 572 DPSSSgpSCLCTFPmdGEHGIPTSVAFTSTEPAHVVASfrSGDTV-LYDLEAGSALLTLESRgssgPAQINQVVSHPSQP 650
Cdd:cd00200 163 DLRTG--KCVATLT--GHTGEVNSVAFSPDGEKLLSSS--SDGTIkLWDLSTGKCLGTLRGH----ENGVNSVAFSPDGY 232

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 89886486 651 LTITAHDDRGIRFLDNRTGKSVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLWS 707
Cdd:cd00200 233 LLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
417-710 1.87e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 165.08  E-value: 1.87e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486 417 LSDSKDAFKKTWNPK-----FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAvtakknaaldvEPIHAFRAHR 491
Cdd:COG2319 136 ASGSADGTVRLWDLAtgkllRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG-----------KLLRTLTGHT 204

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486 492 GPVLAVTMGSNSEYCYSGGADARIHSWkipdlnmDPYDGydpsVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIW 571
Cdd:COG2319 205 GAVRSVAFSPDGKLLASGSADGTVRLW-------DLATG----KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486 572 DPSssGPSCLCTFpmDGEHGIPTSVAFTSTepAHVVASFRSGDTV-LYDLEAGSALLTLESRGssgpAQINQVVSHPSQP 650
Cdd:COG2319 274 DLA--TGELLRTL--TGHSGGVNSVAFSPD--GKLLASGSDDGTVrLWDLATGKLLRTLTGHT----GAVRSVAFSPDGK 343

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486 651 LTITAHDDRGIRFLDNRTGKSVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLWSLDN 710
Cdd:COG2319 344 TLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
432-752 1.48e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 156.61  E-value: 1.48e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486 432 FTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWnlqkavtakknAALDVEPIHAFRAHRGPVLAVTMGSNSEYCYSGGA 511
Cdd:COG2319  30 LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLL-----------DAAAGALLATLLGHTAAVLSVAFSPDGRLLASASA 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486 512 DARIHSWKIpdlnmdpydgyDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSsgPSCLCTFPmdGEHG 591
Cdd:COG2319  99 DGTVRLWDL-----------ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT--GKLLRTLT--GHSG 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486 592 IPTSVAFTSTEpaHVVASFRSGDTV-LYDLEAGSALLTLesRGSSGPaqINQVVSHPSQPLTITAHDDRGIRFLDNRTGK 670
Cdd:COG2319 164 AVTSVAFSPDG--KLLASGSDDGTVrLWDLATGKLLRTL--TGHTGA--VRSVAFSPDGKLLASGSADGTVRLWDLATGK 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486 671 SVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLWSLDNKTCVQEITAHrkkhEEAIHAVACHPSKALIASAGADALAK 750
Cdd:COG2319 238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH----SGGVNSVAFSPDGKLLASGSDDGTVR 313


                ..
gi 89886486 751 VF 752
Cdd:COG2319 314 LW 315
Striatin pfam08232
Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a ...
 65-189 3.70e-40

Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (pfam00400) repeat domain. It acts as a scaffold protein and is involved in signalling pathways.


Pssm-ID: 462401  Cd Length: 85  Bit Score: 142.26  E-value: 3.70e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486    65 LPGILHFIQHEWARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERakyhklkfgtdlnqg 144
Cdd:pfam08232   1 LPGVLHFLQTEWHRHERDRNAWEIERAEMKARIAKLEGERRGQENLKKDLKRRIKMLEYALKQES--------------- 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 89886486   145 ekktdlseqvsngpvesvtlensplVWKEGRQLLRQYLEEVGYTD 189
Cdd:pfam08232  66 -------------------------KRKKSRQYLKKCLQEIGYLD 85
WD40 COG2319
WD40 repeat [General function prediction only];
445-752 7.05e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.79  E-value: 7.05e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486 445 AFHHSQSALLTASEDGTLKLWnlqkavtakknAALDVEPIHAFRAHRGPVLAVTMGSNSEYCYSGGADARIHSWKIpdln 524
Cdd:COG2319   1 ALSADGAALAAASADLALALL-----------AAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDA---- 65

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486 525 mdpydgyDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSgpscLCTFPMDGEHGIPTSVAFTSTepA 604
Cdd:COG2319  66 -------AAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG----LLLRTLTGHTGAVRSVAFSPD--G 132

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486 605 HVVASFRSGDTV-LYDLEAGSALLTLesRGSSGPaqINQVVSHPSQPLTITAHDDRGIRFLDNRTGKSVHSMVAHLDAVT 683
Cdd:COG2319 133 KTLASGSADGTVrLWDLATGKLLRTL--TGHSGA--VTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVR 208

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 89886486 684 CLAVDPNGVFLMSGSHDCSLRLWSLDNKTCVQEITAhrkkHEEAIHAVACHPSKALIASAGADALAKVF 752
Cdd:COG2319 209 SVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTG----HSGSVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 533-572 1.33e-11

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 59.63  E-value: 1.33e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 89886486    533 PSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWD 572
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
538-572 1.45e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 56.58  E-value: 1.45e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 89886486   538 HVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWD 572
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 668-707 1.46e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 1.46e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 89886486    668 TGKSVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLWS 707
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 427-466 2.14e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.39  E-value: 2.14e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 89886486    427 TWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWN 466
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
669-707 2.39e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.42  E-value: 2.39e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 89886486   669 GKSVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLWS 707
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
428-466 3.98e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 3.98e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 89886486   428 WNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWN 466
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 547-692 5.56e-04

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 42.60  E-value: 5.56e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 89886486 547 VW--GLAF-SPTSQR-LASCSADGTVRIWDPSSSG-PSCLCTFpmdGEHGIpTSVAfTSTEPAHVVASFRSGDTVLYDLE 621
Cdd:cd22857 179 VWvtDLTFlSKDDHRkIVTGTGYHQVRLYDTRAQRrPVVSVDF---GETPI-KAVA-EDPDGHTVYVGDTSGDLASIDLR 253

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 89886486 622 AGSALLTLesRGSSGpAQINQVVSHPSQPLTITAHDDRGIRFLDNRTGKSVHSMVA--HLdavTCLAVDPNGV 692
Cdd:cd22857 254 TGKLLGCF--KGKCG-GSIRSIARHPELPLIASCGLDRYLRIWDTETRQLLSKVYLkqRL---TAVVFDSSFS 320
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 669-706 1.82e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 41.21  E-value: 1.82e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 89886486   669 GKSVHSMVAHLDAVTCLAVDPNGVFLMSGSHDCSLRLW 706
Cdd:pfam20426 114 GRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVW 151
WD40 pfam00400
WD domain, G-beta repeat;
482-518 5.22e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 5.22e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 89886486   482 EPIHAFRAHRGPVLAVTMGSNSEYCYSGGADARIHSW 518
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
CusB_dom_1 pfam00529
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ...
 77-130 7.62e-03

Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.


Pssm-ID: 425733 [Multi-domain]  Cd Length: 322  Bit Score: 39.33  E-value: 7.62e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 89886486    77 ARFEAEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERA 130
Cdd:pfam00529  54 TDYQAALDSAEAQLAKAQAQVARLQAELDRLQALESELAISRQDYDGATAQLRA 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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