NCBI Conserved Domain Search

Kelch domain;

410-455

2.24e-15

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 70.28 E-value: 2.24e-15

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 87116679    410 LYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGG 455
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

BTB_POZ_BACH

cd18955

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

62-156

6.87e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349736 [Multi-domain] Cd Length: 94 Bit Score: 70.58 E-value: 6.87e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  62 LCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAEsrqtEVVIRDIDE---RAMELLIDFAYTSQITVEEGNVQTLLP 138
Cdd:cd18955   1 LCDVTIVVEDQRFRAHRAVLAACSDYFLSRVVGQTDG----DLVITLPEEvtvKGFEPLLQFAYTAKLLLSKENVLEVCR 76

                        90
                ....*....|....*...
gi 87116679 139 AACLLQLAEIQEACCEFL 156
Cdd:cd18955  77 CAEFLGVHNIEKACFDFL 94

BACK_KLHL33

cd18472

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...

160-234

7.11e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.

Pssm-ID: 350547 [Multi-domain] Cd Length: 75 Bit Score: 69.72 E-value: 7.11e-15

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 87116679 160 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWV 234
Cdd:cd18472   1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75

BTB_POZ_BACH2

cd18278

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

40-156

7.15e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349587 [Multi-domain] Cd Length: 124 Bit Score: 71.52 E-value: 7.15e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  40 YISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGElAESRQTEVVIRDIDERAMELLID 119
Cdd:cd18278   9 YESTVHCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGQ-TENDLVVSLPEEVTARGFGPLLQ 87

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 87116679 120 FAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFL 156
Cdd:cd18278  88 FAYTAKLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124

Kelch

Kelch domain;

314-360

8.12e-15

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 68.74 E-value: 8.12e-15

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 87116679    314 VLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDD 360
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

Kelch

Kelch domain;

361-408

8.28e-15

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 68.74 E-value: 8.28e-15

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 87116679    361 LLYAVGGHDGSSYLNSVERYDPKTNQWSSdVAPTSTCRTSVGVAVLGG 408
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTP-LPSMPTPRSGHGVAVING 47

BTB_POZ_SPOP-like

cd18279

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

54-160

8.37e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349588 [Multi-domain] Cd Length: 120 Bit Score: 71.02 E-value: 8.37e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  54 NLLRKHReLCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNV 133
Cdd:cd18279  11 NLWENSR-FTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDKMA 89

                        90       100
                ....*....|....*....|....*..
gi 87116679 134 QTLLPAACLLQLAEIQEACCEFLKRQL 160
Cdd:cd18279  90 DDLLAAADKYALERLKVMCEDALCSNL 116

BTB_POZ_ZBTB27-like

cd18215

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

44-155

1.26e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349524 [Multi-domain] Cd Length: 113 Bit Score: 70.29 E-value: 1.26e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  44 KHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYT 123
Cdd:cd18215   1 RHASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDQLKNNVSVINLDPEIEPEGFRILLDFMYT 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 87116679 124 SQITVEEGNVQTLLPAACLLQLAEIQEACCEF 155
Cdd:cd18215  81 SRLNLREGNIMAVMATAMYLQMEHVVDTCRKF 112

BTB_POZ_ZBTB7B_ZBTB15

cd18327

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-157

2.39e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349636 [Multi-domain] Cd Length: 127 Bit Score: 69.87 E-value: 2.39e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  31 GVPQParmpyisdKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESR------QTEV 104
Cdd:cd18327   2 GIPFP--------EHSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGGGSGdlgaggGQDV 73

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 87116679 105 VIRD-IDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLK 157
Cdd:cd18327  74 CELDfVGPEALGALLEFAYTATLTISSSNMREVLRAARLLEIPCVADACADILQ 127

BTB_POZ_calicin

cd18307

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

63-155

4.06e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349616 [Multi-domain] Cd Length: 97 Bit Score: 68.29 E-value: 4.06e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  63 CDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERA---MELLIDFAYTSQITVEEGNVQTLLPA 139
Cdd:cd18307   2 CDVVISVDNHSFAAHRNVLAAVSPFVKSLISSNDMKATDELSITIDCDYLSpetVEQLLDYFYTGKIVISEKNVEDLLKG 81

                        90
                ....*....|....*.
gi 87116679 140 ACLLQLAEIQEACCEF 155
Cdd:cd18307  82 AKYFNIPRLKDHCVDF 97

BACK_KLHL23

cd18462

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...

160-256

5.22e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.

Pssm-ID: 350537 [Multi-domain] Cd Length: 102 Bit Score: 68.22 E-value: 5.22e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679 160 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQ 239
Cdd:cd18462   1 LDIDNCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVE 80

                        90
                ....*....|....*..
gi 87116679 240 ERRPQLPQVLQHVRLPL 256
Cdd:cd18462  81 KRIECAYDLLSSIKLDL 97

BTB_POZ_BTBD18

cd18293

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

55-154

6.45e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349602 [Multi-domain] Cd Length: 120 Bit Score: 68.66 E-value: 6.45e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  55 LLRKHRE-----LCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGEL-AESRQTEVVIRDIDERAMELLIDFAYTSQITV 128
Cdd:cd18293   3 FLQLHRQqnsgvFCDVLLQAEGESVPAHCCVLSACSPYLTERLSSEPpPAGQKVVLELQGLKAHTLLKLVDFLYTSELEV 82

                        90       100
                ....*....|....*....|....*.
gi 87116679 129 EEGNVQTLLPAACLLQLAEIQEACCE 154
Cdd:cd18293  83 SSEEAQDVLAAARRLQISELESLCLE 108

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

349-388

7.65e-14

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 65.71 E-value: 7.65e-14

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 87116679   349 RRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWS 388
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWS 40

BTB_POZ_KLHL15

cd18244

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

40-165

8.25e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349553 [Multi-domain] Cd Length: 137 Bit Score: 68.83 E-value: 8.25e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  40 YISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLID 119
Cdd:cd18244   8 YNSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQ 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 87116679 120 FAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNC 165
Cdd:cd18244  88 FMYYGTIELSMLTVHEILQAAMYVQLTEVVKFCCSFLLAKICLDNC 133

BTB_POZ_ZBTB47_ZNF651

cd18231

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

61-159

1.10e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349540 [Multi-domain] Cd Length: 115 Bit Score: 67.64 E-value: 1.10e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  61 ELCDVVLVVGAKK--IYAHRVILSACSPYFRAMFTgELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLP 138
Cdd:cd18231  13 DLCDVDIVLVRQRstFPAHKGVLAAYSQFFHSLFT-QNKQLQRVELSLEALTSQGLQQILNFIYTSKLLVNSCNVQDVLN 91

                        90       100
                ....*....|....*....|.
gi 87116679 139 AACLLQLAEIQEACCEFLKRQ 159
Cdd:cd18231  92 AAAVLQMNDIAASCQELIDSR 112

BACK_KBTBD6_7

cd18482

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...

160-253

1.38e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.

Pssm-ID: 350557 [Multi-domain] Cd Length: 99 Bit Score: 66.76 E-value: 1.38e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679 160 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVM-ESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSI 238
Cdd:cd18482   1 LDLSNCAGILKFADAFDNRELKSKALAFIARNFQQLLaKEEELCELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANL 80

                        90
                ....*....|....*
gi 87116679 239 QERRPQLPQVLQHVR 253
Cdd:cd18482  81 KERAASAAEVLKCVR 95

BTB_POZ_ZBTB11

cd18202

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

44-152

1.48e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349511 [Multi-domain] Cd Length: 118 Bit Score: 67.57 E-value: 1.48e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  44 KHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVV-IRDIDERAMELLIDFAY 122
Cdd:cd18202   1 KHGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIEKGAVSSHEAVVdLSGFCKSSFLPLLEFAY 80

                        90       100       110
                ....*....|....*....|....*....|
gi 87116679 123 TSQITVEEGNVQTLLPAACLLQLAEIQEAC 152
Cdd:cd18202  81 TSELTFDFCSMAEVAMLARHLFMNEVLEIC 110

BACK_KLHL35

cd18474

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...

160-234

1.53e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.

Pssm-ID: 350549 [Multi-domain] Cd Length: 79 Bit Score: 65.99 E-value: 1.53e-13

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 87116679 160 LDPSNCLGIRAFADTHSCREL-LRIADKFTQHnFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWV 234
Cdd:cd18474   1 IGANNCLALLAAADALHCAPLqEHCIRVLLRD-FAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWV 75

BTB_POZ_BTBD17

cd18292

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

47-155

1.54e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349601 [Multi-domain] Cd Length: 114 Bit Score: 67.31 E-value: 1.54e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  47 RQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFT-GELAESRQTEVVIRDIDE--RAMELLIDFAYT 123
Cdd:cd18292   2 REFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSnDWWSESKQSEIELVEDPEcaAVFEKFLRYLYT 81

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 87116679 124 SQITVeegNVQTLLPaacLLQLAE------IQEACCEF 155
Cdd:cd18292  82 GQISV---NLETALP---LLMLADkynvtdLKQLCVDF 113

Kelch

Kelch domain;

504-549

1.81e-13

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 64.89 E-value: 1.81e-13

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 87116679    504 IYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNG 549
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

BTB_POZ_ZBTB27_BCL6

cd18331

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

44-156

1.95e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349640 [Multi-domain] Cd Length: 118 Bit Score: 67.19 E-value: 1.95e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  44 KHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYT 123
Cdd:cd18331   6 RHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEINPEGFNILLDFMYT 85

                        90       100       110
                ....*....|....*....|....*....|...
gi 87116679 124 SQITVEEGNVQTLLPAACLLQLAEIQEACCEFL 156
Cdd:cd18331  86 SRLNLREGNIMAVMATAMYLQMEHVVDTCRKFI 118

BTB_POZ_ZBTB48_TZAP_KR3

cd18232

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

45-155

5.47e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349541 [Multi-domain] Cd Length: 108 Bit Score: 65.55 E-value: 5.47e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  45 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESrqteVVIRDIDERAMELLIDFAYTS 124
Cdd:cd18232   1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGTSGS----VVLPESFAEVFGLLLDFFYTG 76

                        90       100       110
                ....*....|....*....|....*....|.
gi 87116679 125 QITVEEGNVQTLLPAACLLQLAEIQEACCEF 155
Cdd:cd18232  77 ELALTRENRDRVLLAAKELRVPEAVELCQRF 107

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

444-489

6.06e-13

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 63.40 E-value: 6.06e-13

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 87116679   444 RRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMG 489
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46

Kelch

Kelch domain;

457-502

6.44e-13

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 63.35 E-value: 6.44e-13

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 87116679    457 LYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQD 502
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

398-442

6.62e-13

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 63.01 E-value: 6.62e-13

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 87116679   398 RTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMS 442
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46

BTB_POZ_ZBTB3-like

cd18194

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

45-152

1.11e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349503 [Multi-domain] Cd Length: 128 Bit Score: 65.23 E-value: 1.11e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  45 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRaMFTGELAESRQTEVVIRDI-DERAMELLIDFAYT 123
Cdd:cd18194   6 HSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFH-LFYRDRLDKRDLVRLNSDIvTAPAFGLLLDFMYE 84

                        90       100
                ....*....|....*....|....*....
gi 87116679 124 SQITVEEGNVQTLLPAACLLQLAEIQEAC 152
Cdd:cd18194  85 GRLALRDLPVEDVLAAASYLHMYDIVKVC 113

BTB_POZ_roadkill-like

cd18345

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

64-164

2.03e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349654 [Multi-domain] Cd Length: 121 Bit Score: 64.10 E-value: 2.03e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  64 DVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLL 143
Cdd:cd18345  20 DVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTGKAPNLDKMADDLLAAADKY 99

                        90       100
                ....*....|....*....|.
gi 87116679 144 QLAEIQEACCEFLKRQLDPSN 164
Cdd:cd18345 100 ALERLKVMCEEALCSNLSVEN 120

BACK_KLHL26

cd18465

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...

165-257

2.04e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.

Pssm-ID: 350540 Cd Length: 97 Bit Score: 63.39 E-value: 2.04e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679 165 CLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSiQERRPQ 244
Cdd:cd18465   6 CLNIGQMATTFSLASLKESVDAFTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHD-PSRRAS 84

                        90
                ....*....|...
gi 87116679 245 LPQVLQHVRLPLL 257
Cdd:cd18465  85 ASHVLCHIRFPLM 97

BTB_POZ_BTBD3_6

cd18282

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

64-160

2.13e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349591 [Multi-domain] Cd Length: 108 Bit Score: 63.57 E-value: 2.13e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  64 DVVLVVG----AKKIYAHRVILSACSPYFRAMFTGELAESRQtEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPA 139
Cdd:cd18282   9 DVHFIVGppggTQRIPAHKYVLATGSSVFYAMFYGGLAENKN-EIEIPDVEPAAFLNLLRYLYCDEIDLEPDTVLATLYA 87

                        90       100
                ....*....|....*....|.
gi 87116679 140 ACLLQLAEIQEACCEFLKRQL 160
Cdd:cd18282  88 AKKYLVPHLARACVQFLETSL 108

BTB2_POZ_RhoBTB

cd18300

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

61-160

2.16e-12

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349609 [Multi-domain] Cd Length: 108 Bit Score: 63.80 E-value: 2.16e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  61 ELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITV-EEGNVQTLLPA 139
Cdd:cd18300   8 LFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQAPIlEDGDCVGLIVL 87

                        90       100
                ....*....|....*....|.
gi 87116679 140 ACLLQLAEIQEACCEFLKRQL 160
Cdd:cd18300  88 ANRLCLPRLVALCEQYIVKEL 108

BTB_POZ_ZBTB3

cd18323

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

45-160

2.29e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349632 [Multi-domain] Cd Length: 128 Bit Score: 64.46 E-value: 2.29e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  45 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRaMFTGELAESRQTEVVIRDI-DERAMELLIDFAYT 123
Cdd:cd18323   6 HSRHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFH-MFYKEQLDKRDLVCINNEIvTAPAFSLLLEFMYE 84

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 87116679 124 SQITVEEGNVQTLLPAACLLQLAEIQEACceflKRQL 160
Cdd:cd18323  85 GRLSFNDTPVEDVLAAASYLHMNDIVKVC----KKRL 117

BTB_POZ_ZBTB37

cd18222

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

50-157

2.75e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349531 [Multi-domain] Cd Length: 123 Bit Score: 63.91 E-value: 2.75e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  50 LEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFR-AMFTGELaeSRQTEVVIRdiDERAMELLIDFAYTSQITV 128
Cdd:cd18222  13 LSHLNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFRdHMSLNEM--STVSISVIK--NPTVFEQLLSFCYTGRICL 88

                        90       100
                ....*....|....*....|....*....
gi 87116679 129 EEGNVQTLLPAACLLQLAEIQEACCEFLK 157
Cdd:cd18222  89 QLADIISYLTAASFLQMQHIIDKCTQILE 117

BTB_POZ_ZBTB6

cd18197

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

50-156

3.03e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349506 [Multi-domain] Cd Length: 116 Bit Score: 63.74 E-value: 3.03e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  50 LEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTgeLAESRQTEVVIRDIDERAMELLIDfAYTSQITVE 129
Cdd:cd18197  13 LQKMNLLRQQNLFCDVSIYINDTEFHGHKVILAACSTFMRDQFL--LNQSKQVRITILQSAEVGRKLLLS-CYTGALEVK 89

                        90       100
                ....*....|....*....|....*..
gi 87116679 130 EGNVQTLLPAACLLQLAEIQEACCEFL 156
Cdd:cd18197  90 KKELLKYLTAASYLQMVHIVEKCTEAL 116

BACK_calicin

cd18503

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...

160-236

4.50e-12

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.

Pssm-ID: 350578 [Multi-domain] Cd Length: 78 Bit Score: 61.98 E-value: 4.50e-12

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 87116679 160 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKY 236
Cdd:cd18503   1 LDRDNCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEH 77

BTB_POZ_ZBTB26_Bioref

cd18214

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

43-162

4.73e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349523 [Multi-domain] Cd Length: 122 Bit Score: 63.31 E-value: 4.73e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  43 DKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTgeLAESRQTEVVIRDIDERAMELLIDfAY 122
Cdd:cd18214   6 ENYGDSMLQKMNKLREQNKFCDVTVHIDDLEVPGHKVVFAAGSPFLRDQFL--LNDSREVQISILQNSEVGRQLLLS-CY 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 87116679 123 TSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDP 162
Cdd:cd18214  83 TGVLEFPEMELVNYLTAASFLQMSHIVERCTQALWKFIKP 122

BTB_POZ_SPOPL

cd18343

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

56-164

5.84e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349652 [Multi-domain] Cd Length: 123 Bit Score: 63.10 E-value: 5.84e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  56 LRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQT 135
Cdd:cd18343  15 LWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDKMADN 94

                        90       100
                ....*....|....*....|....*....
gi 87116679 136 LLPAACLLQLAEIQEACCEFLKRQLDPSN 164
Cdd:cd18343  95 LLAAADKYALERLKVMCEEALCNNLSVEN 123

BTB_POZ_ZBTB10

cd18201

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

48-161

6.62e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349510 [Multi-domain] Cd Length: 122 Bit Score: 62.67 E-value: 6.62e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  48 QTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESR-QTEVVIRDIDE-RAMELLIDFAYTSQ 125
Cdd:cd18201   7 QLLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKESCdQTTVTHLDVVAvQGFSVILDFMYSGN 86

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 87116679 126 ITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLD 161
Cdd:cd18201  87 LVLTSQNAIEVMSVASYLQMTEVVQSCRNFIKDALN 122

BTB_POZ_BPM_plant

cd18280

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

54-123

7.53e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349589 [Multi-domain] Cd Length: 121 Bit Score: 62.73 E-value: 7.53e-12

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  54 NLLRKhRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYT 123
Cdd:cd18280   7 ALLES-EEGADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYK 75

BTB_POZ_ZBTB21_ZNF295

cd18209

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

45-136

7.65e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349518 [Multi-domain] Cd Length: 112 Bit Score: 62.20 E-value: 7.65e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  45 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESrQTEVVIRDIDERAMELLIDFAYTS 124
Cdd:cd18209   1 HAISLLSALNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTEKENES-QSVFQLDFCEPDAFENVLNYIYSS 79

                        90
                ....*....|..
gi 87116679 125 QITVEEGNVQTL 136
Cdd:cd18209  80 SLFVEKSSLAAV 91

BACK_KLHL11

cd18451

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...

160-241

1.12e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.

Pssm-ID: 350526 [Multi-domain] Cd Length: 88 Bit Score: 61.13 E-value: 1.12e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679 160 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQ 239
Cdd:cd18451   1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                ..
gi 87116679 240 ER 241
Cdd:cd18451  81 ER 82

BACK_BTBD9

cd14822

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...

132-258

1.37e-11

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.

Pssm-ID: 350518 [Multi-domain] Cd Length: 101 Bit Score: 61.09 E-value: 1.37e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679 132 NVQTLLPAACLLQLAEIQEACCEFLKRqldpsnclgirafadthscrellriadkftqhNFQEVMESEEFMLLPANQLID 211
Cdd:cd14822   5 NVCLIYDVASLYSLDDLCQTCCQFMDR--------------------------------NAQEVLSSEGFLTLSKSALKE 52

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 87116679 212 IISSDELNVrSEEQVFNAVMAWVKYSiQERRPQLPQVLQHVRLPLLS 258
Cdd:cd14822  53 LLSRDSFCA-PEVDIFNAVRRWCEHN-PDSKEDAKEILEAVRLPLMS 97

BTB_POZ_KLHL14_printor

cd18243

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

45-164

1.47e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349552 [Multi-domain] Cd Length: 130 Bit Score: 61.98 E-value: 1.47e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  45 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTgelaesrQTEVVIRDIDERAMELLIDFAYTS 124
Cdd:cd18243  15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS-------INNLVLQGCSSIGLRLVLEYLYTA 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 87116679 125 QITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSN 164
Cdd:cd18243  88 NVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127

BTB_POZ_ZBTB49

cd18233

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

62-157

2.18e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349542 [Multi-domain] Cd Length: 112 Bit Score: 61.06 E-value: 2.18e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  62 LCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGelAESRQTEVVIRDI-DERAMELLIDFAYTSQITVEEGNVQTLLPAA 140
Cdd:cd18233  18 LCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQN--SSSQKNDVFHLDIkNVGGIGQILDFMYTSHLDLNQDNVQVMLDIA 95

                        90
                ....*....|....*..
gi 87116679 141 CLLQLAEIQEACCEFLK 157
Cdd:cd18233  96 QCLQVQNVLNMCYTFLK 112

BTB_POZ_ARIA_plant

cd18352

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

62-140

2.22e-11

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349661 [Multi-domain] Cd Length: 116 Bit Score: 60.95 E-value: 2.22e-11

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 87116679  62 LCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAA 140
Cdd:cd18352  13 LSDVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLLRAA 91

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

538-583

2.63e-11

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 58.78 E-value: 2.63e-11

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 87116679   538 RRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGMN 583
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46

BTB_POZ_KBTBD11

cd18275

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

64-168

2.86e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349584 [Multi-domain] Cd Length: 104 Bit Score: 60.58 E-value: 2.86e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  64 DVVLVVGAKKIYAHRVILSACSPYFRAMFtgelaeSRQTeVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLL 143
Cdd:cd18275   6 DLVIEVSGQRIRAHKSVLAAKSDYFRARL------SRDI-LKVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARFL 78

                        90       100
                ....*....|....*....|....*
gi 87116679 144 QLAEIQEACCEFLKRQLDPSNCLGI 168
Cdd:cd18275  79 QMPCAAQCAVDAVRAQLCLGNCYEV 103

BTB_POZ_ZBTB31_myoneurin

cd18217

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

45-152

2.87e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349526 [Multi-domain] Cd Length: 111 Bit Score: 60.54 E-value: 2.87e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  45 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFtgelaESRQTEVVIRD---IDERAMELLIDFA 121
Cdd:cd18217   1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQY-----KDTEDNIVFLDqsqVSADGFQKLLEFI 75

                        90       100       110
                ....*....|....*....|....*....|.
gi 87116679 122 YTSQITVEEGNVQTLLPAACLLQLAEIQEAC 152
Cdd:cd18217  76 YTGNLNLDSWNVAEIHQAASYLGMEEVVAKC 106

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

491-536

3.82e-11

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 58.01 E-value: 3.82e-11

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 87116679   491 RRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAMT 536
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46

Kelch

Kelch domain;

550-594

3.97e-11

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 57.95 E-value: 3.97e-11

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 87116679    550 QLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGMNYRRLGGGVGVI 594
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVI 45

BTB_POZ_ZBTB23_GZF1

cd18211

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

42-160

5.44e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349520 [Multi-domain] Cd Length: 128 Bit Score: 60.25 E-value: 5.44e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  42 SDKHPRQTLEVINLLRKHRELCDVVLVV---GAKKIY-AHRVILSACSPYFRAMFTGE-LAESRQTEVVIRDIDERAMEL 116
Cdd:cd18211   5 SKSAPSNLLNEMHKLRLLGHLCDVTVQVehqGSKEEFsAHKAVLAASSKYFKEVFLNEkISDGKNTNVMLNEIYTADFAS 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 87116679 117 LIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEfLKRQL 160
Cdd:cd18211  85 FLEFVYTAKVEVEEDRVQRMLEIAEKLKCLDLSETCFQ-LKKQM 127

BTB_POZ_ZBTB29-like

cd18216

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

45-158

5.49e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349525 [Multi-domain] Cd Length: 118 Bit Score: 60.24 E-value: 5.49e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  45 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVirdiDERAMELLIDFAYTS 124
Cdd:cd18216   3 HATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLVLHDNLIHLDQDMV----SPTVFQQILDFIYTG 78

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 87116679 125 QI---TVEEGNVQTLLPAACLLQLAEIQEACCEFLKR 158
Cdd:cd18216  79 KLldsLFEEPNLSEVLAAANYLQLPDLAALCRSKLKR 115

BTB_POZ_ZBTB18_2-like

cd18325

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

45-157

6.35e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349634 [Multi-domain] Cd Length: 128 Bit Score: 60.05 E-value: 6.35e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  45 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELaESRQTEVVIRDI-DERAMELLIDFAYT 123
Cdd:cd18325   6 HSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFHLFYRDQL-DKRDIVHLNSDIvTAPAFSLLLEFMYE 84

                        90       100       110
                ....*....|....*....|....*....|....
gi 87116679 124 SQITVEEGNVQTLLPAACLLQLAEIQEACCEFLK 157
Cdd:cd18325  85 GKLEFSSLPVEDVLAAASYLHMYDIVKVCKGKLK 118

BTB_POZ_ZBTB43

cd18227

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

50-157

8.05e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349536 [Multi-domain] Cd Length: 121 Bit Score: 59.57 E-value: 8.05e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  50 LEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTgeLAESRQteVVIRDI-DERAMELLIDFAYTSQITV 128
Cdd:cd18227  13 LQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFCDQVL--LKNSRR--IVLPDVmNPRVFENILLSCYTGRLVL 88

                        90       100
                ....*....|....*....|....*....
gi 87116679 129 EEGNVQTLLPAACLLQLAEIQEACCEFLK 157
Cdd:cd18227  89 PAPEIVSYLTAASFLQMWHVVDKCTELLE 117

PLN02153

epithiospecifier protein

350-556

8.31e-11

epithiospecifier protein

Pssm-ID: 177814 [Multi-domain] Cd Length: 341 Bit Score: 63.85 E-value: 8.31e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  350 RCGVGVSVLDDLLYAVGGH-------DGSSYLnsverYDPKTNQWS----SDVAPTSTCRTSVGVAVlGGFLYAVGGQDG 418
Cdd:PLN02153  23 RCSHGIAVVGDKLYSFGGElkpnehiDKDLYV-----FDFNTHTWSiapaNGDVPRISCLGVRMVAV-GTKLYIFGGRDE 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  419 VSCLNIVERYDPKENKWTRVASMSTR-----RLGVAVAVLGGFLYAVGG-SDG---TSP--LNTVERYNPQENRWHTIAP 487
Cdd:PLN02153  97 KREFSDFYSYDTVKNEWTFLTKLDEEggpeaRTFHSMASDENHVYVFGGvSKGglmKTPerFRTIEAYNIADGKWVQLPD 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  488 MG---TRRKHLGCAVYQDMIYAV---------GGRDDtTELSSAERYNPRTNQWSPVV---AMTSRRSGVGLAVVNGQLM 552
Cdd:PLN02153 177 PGenfEKRGGAGFAVVQGKIWVVygfatsilpGGKSD-YESNAVQFFDPASGKWTEVEttgAKPSARSVFAHAVVGKYII 255


                 ....
gi 87116679  553 AVGG 556
Cdd:PLN02153 256 IFGG 259

BTB_POZ_BTBD6

cd18349

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

55-160

9.70e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349658 [Multi-domain] Cd Length: 109 Bit Score: 59.23 E-value: 9.70e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  55 LLRKHRELCDVVLVVGA----KKIYAHRVILSACSPYFRAMFTGELAESRqTEVVIRDIDERAMELLIDFAYTSQITVEE 130
Cdd:cd18349   1 LMFNNELMADVHFIVGPpgasQRVPAHKYVLAVGSSVFYAMFYGDLAEVK-SEIHIPDVEPAAFLILLKYMYSDEIDLEA 79

                        90       100       110
                ....*....|....*....|....*....|
gi 87116679 131 GNVQTLLPAACLLQLAEIQEACCEFLKRQL 160
Cdd:cd18349  80 DTVLATLYAAKKYIVPALAKACVNFLETSL 109

BTB_POZ_ZBTB24_ZNF450

cd18212

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

42-151

1.04e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349521 [Multi-domain] Cd Length: 118 Bit Score: 59.42 E-value: 1.04e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  42 SDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGElAESRQTEVVIRDIDERAMELLIDFA 121
Cdd:cd18212   3 SKTHKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFADE-GEVGQSIYMLEGMVAETFGALLEFI 81

                        90       100       110
                ....*....|....*....|....*....|
gi 87116679 122 YTSQITVEEGNVQTLLPAACLLQLAEIQEA 151
Cdd:cd18212  82 YTGCLQVGEKSLEQILATAQFLKVNDLVKA 111

BTB_POZ_TDPOZ

cd18344

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

39-164

1.19e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349653 [Multi-domain] Cd Length: 128 Bit Score: 59.58 E-value: 1.19e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  39 PYISDkhPRQTLEV-INLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELL 117
Cdd:cd18344   1 PAIKD--PRHMLTDdLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEM 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 87116679 118 IDFAYTSQI-TVEEGNVQT-LLPAACLLQLAEIQEACCEFLKRQLDPSN 164
Cdd:cd18344  79 MGFIYTGKApHLHSHSMACdVLAAADKYGLEGLKVLCEDALCRNLSVEN 127

BTB_POZ_BTBD2

cd18347

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

62-164

1.30e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349656 [Multi-domain] Cd Length: 127 Bit Score: 59.32 E-value: 1.30e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  62 LCDVVLVVG----AKKIYAHRVILSACSPYFRAMFTGELAESrQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLL 137
Cdd:cd18347  22 LSDVHFLVGkglgSQRIPAHRFVLAVGSAVFDAMFNGGMATT-STEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTL 100

                        90       100
                ....*....|....*....|....*..
gi 87116679 138 PAACLLQLAEIQEACCEFLKRQLDPSN 164
Cdd:cd18347 101 YTAKKYAVPALEAHCVEFLKKNLRADN 127

BTB_POZ_ZBTB12

cd18203

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

45-162

1.37e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349512 [Multi-domain] Cd Length: 122 Bit Score: 59.12 E-value: 1.37e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  45 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTgeLAESRQTEVVIRDIDERAMELLIDfAYTS 124
Cdd:cd18203   8 HEAATLRNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQFL--LNPSSELQVSLMHSSRVVADLLLS-CYTG 84

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 87116679 125 QITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDP 162
Cdd:cd18203  85 ALEFSVRDIVNYLTAASYLQMEHVVEKCRGALSQFIEP 122

PLN02193

nitrile-specifier protein

398-576

1.41e-10

nitrile-specifier protein

Pssm-ID: 177844 [Multi-domain] Cd Length: 470 Bit Score: 63.82 E-value: 1.41e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  398 RTSVGVAVLGGFLYAVGGQdgvsclniverYDPKE--NKWTRVASMSTRR---------------LGVAVAVLGGFLYAV 460
Cdd:PLN02193 166 RCSHGIAQVGNKIYSFGGE-----------FTPNQpiDKHLYVFDLETRTwsispatgdvphlscLGVRMVSIGSTLYVF 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  461 GGSDGTSPLNTVERYNPQENRWHTIAPMG---TRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQW----SPVV 533
Cdd:PLN02193 235 GGRDASRQYNGFYSFDTTTNEWKLLTPVEegpTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWfhcsTPGD 314

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 87116679  534 AMTSrRSGVGLAVVNGQLMAVGGFDGTTyLKTIEVFDPDANTW 576
Cdd:PLN02193 315 SFSI-RGGAGLEVVQGKVWVVYGFNGCE-VDDVHYYDPVQDKW 355

BTB_POZ_GCL

cd18305

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

64-157

1.43e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349614 [Multi-domain] Cd Length: 115 Bit Score: 58.83 E-value: 1.43e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  64 DVVLVVGAKKIYAHRVILSACsPYFRAMFTGELAESRQTEVVIRDIDER--AMELLIDFA--YTSQITVEEGNVQTLLPA 139
Cdd:cd18305  17 DITICALGREWKLHKIYLCQS-GYFASMFSGSWKESKETVINLEIPDDNitVEALNVVFGslYRDEIEIKPSRVVSILAA 95

                        90
                ....*....|....*...
gi 87116679 140 ACLLQLAEIQEACCEFLK 157
Cdd:cd18305  96 ATLLQLDGLIQQCSEVMK 113

BTB_POZ_ZBTB30_HIC2

cd18334

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

45-158

1.79e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349643 [Multi-domain] Cd Length: 120 Bit Score: 58.83 E-value: 1.79e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  45 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVirdiDERAMELLIDFAYTS 124
Cdd:cd18334   4 HAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLVLHDNLINLDTDMV----NPTVFRQILDFIYTG 79

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 87116679 125 QITVE----EGNVQTLLPAACLLQLAEIQEACCEFLKR 158
Cdd:cd18334  80 KLLTSdqpgEQNFNALLTAASYLQLHDLAALCRKKLKR 117

BTB_POZ_BTBD14B_NAC1

cd18290

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

50-155

1.84e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349599 [Multi-domain] Cd Length: 123 Bit Score: 58.89 E-value: 1.84e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  50 LEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRdidERAMELLIDFAYTSQITVE 129
Cdd:cd18290  15 LECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELPAAVQ---PQSFQQILSFCYTGRLSMN 91

                        90       100
                ....*....|....*....|....*.
gi 87116679 130 EGNVQTLLPAACLLQLAEIQEACCEF 155
Cdd:cd18290  92 VGDQFLLMYTAGFLQIQEIMEKGTEF 117

BTB_POZ_ZBTB14

cd18204

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

45-160

2.15e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349513 [Multi-domain] Cd Length: 114 Bit Score: 58.12 E-value: 2.15e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  45 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTeVVIRDIDERAMELLIDFAYTS 124
Cdd:cd18204   1 HKTVFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSSV-IEIDFLRSDIFEEVLNYMYTA 79

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 87116679 125 QITVEEGNVQTLLPAACLLQLAEIQEACCEflKRQL 160
Cdd:cd18204  80 KISVKKEDVNLMMSSGQILGIRFLDKLCSQ--KRDV 113

BTB_POZ_ZBTB42

cd18956

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

56-163

2.80e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349737 [Multi-domain] Cd Length: 129 Bit Score: 58.29 E-value: 2.80e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  56 LRKHRE---LCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDI-DERAMELLIDFAYTSQITVEEG 131
Cdd:cd18956  14 LRQQRElgfLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRPAGGRDTVRLNGDIvTAPAFGRLLDFMYEGRLDLRSL 93

                        90       100       110
                ....*....|....*....|....*....|..
gi 87116679 132 NVQTLLPAACLLQLAEIQEACCEFLkRQLDPS 163
Cdd:cd18956  94 PVEDVLAAASYLHMYDIVKVCKGRL-REKDPA 124

BTB_POZ_ZBTB18_RP58

cd18324

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

45-159

2.89e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349633 [Multi-domain] Cd Length: 147 Bit Score: 58.90 E-value: 2.89e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  45 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELaESRQTEVVIRDI-DERAMELLIDFAYT 123
Cdd:cd18324   6 HSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQL-DKRDIVHLNSDIvTAPAFALLLEFMYE 84

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 87116679 124 SQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQ 159
Cdd:cd18324  85 GKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEK 120

BTB2_POZ_BTBD8

cd18286

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

64-158

4.97e-10

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349595 [Multi-domain] Cd Length: 121 Bit Score: 57.27 E-value: 4.97e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  64 DVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYtSQITVEEGNVQ--TLLPAAC 141
Cdd:cd18286  19 DITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIY-GGVLDLPDDVNlgELLSLAD 97

                        90
                ....*....|....*..
gi 87116679 142 LLQLAEIQEACCEFLKR 158
Cdd:cd18286  98 MYGLDGLKDVVAYTLRR 114

BTB1_POZ_RhoBTB

cd18299

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

54-157

6.82e-10

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349608 [Multi-domain] Cd Length: 103 Bit Score: 56.45 E-value: 6.82e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  54 NLLrkHRELC-DVVLVVGAK-KIYAHRVILSACSPYFRAMFtgelaeSRQTEVVI-RDIDERAMELLIDFAYTSQITVEE 130
Cdd:cd18299   5 NLL--HSPSCaDVVFILQGGvRIFAHRIVLAAASSVFADLF------LMMTVVTLdSDITPEAFRRVLEFLYTGVLDENE 76

                        90       100
                ....*....|....*....|....*..
gi 87116679 131 GNVQTLLPAACLLQLAEIQEACCEFLK 157
Cdd:cd18299  77 DDLKELKDAAELLELFDLVMMCTNVLN 103

BTB_POZ_ZBTB8A_BOZF1

cd18329

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

45-156

8.08e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349638 [Multi-domain] Cd Length: 116 Bit Score: 56.76 E-value: 8.08e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  45 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDI-DERAMELLIDFAYT 123
Cdd:cd18329   4 HQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVATFDVfSPDTFTIILDFVYS 83

                        90       100       110
                ....*....|....*....|....*....|...
gi 87116679 124 SQITVEEGNVQTLLPAACLLQLAEIQEACCEFL 156
Cdd:cd18329  84 GKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116

BACK_KLHL31_KBTBD1

cd18470

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...

164-258

8.58e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).

Pssm-ID: 350545 Cd Length: 98 Bit Score: 56.04 E-value: 8.58e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679 164 NCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSiQERRP 243
Cdd:cd18470   5 NCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFD-QKRVK 83

                        90
                ....*....|....*
gi 87116679 244 QLPQVLQHVRLPLLS 258
Cdd:cd18470  84 YAADLLSNIRFGTIS 98

BTB_POZ_ZBTB8

cd18199

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

45-156

1.08e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349508 [Multi-domain] Cd Length: 113 Bit Score: 56.28 E-value: 1.08e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  45 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDI-DERAMELLIDFAYT 123
Cdd:cd18199   1 HQSRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTGRPSTASFDVfSSDAFSIILDFVYS 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 87116679 124 SQITVEEGNVQTLLPAACLLQLAEIQEACCEFL 156
Cdd:cd18199  81 GKLSLTSQNVIEVMSAASYLQMTDVINVCKTFI 113

BTB_POZ_ZBTB8B

cd18330

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

53-152

1.57e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349639 [Multi-domain] Cd Length: 113 Bit Score: 55.70 E-value: 1.57e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  53 INLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDI-DERAMELLIDFAYTSQITVEEG 131
Cdd:cd18330   9 LNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTASLDIvTSEAFSIILDFLYSGKLDLCSE 88

                        90       100
                ....*....|....*....|.
gi 87116679 132 NVQTLLPAACLLQLAEIQEAC 152
Cdd:cd18330  89 NVIEVMSAASYLQMTDVVNFC 109

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

311-347

1.95e-09

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 53.38 E-value: 1.95e-09

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 87116679   311 CGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMS 347
Cdd:pfam01344  10 VGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46

BTB1_POZ_KLHL33

cd18262

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

45-140

2.36e-09

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349571 [Multi-domain] Cd Length: 101 Bit Score: 54.91 E-value: 2.36e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  45 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRamftGELAESRQTEVVIR-DIDERAMELLIDFAYT 123
Cdd:cd18262   1 HPSQFFGEAQRLREQRLLLDETVSVGGRSYGVHSVILAAVSSLFR----ERLLGSNGPLPPLSlEVTPVGWEAVLTFAYT 76

                        90
                ....*....|....*..
gi 87116679 124 SQITVEEGNVQTLLPAA 140
Cdd:cd18262  77 GVLGRNPATVGDILVAA 93

BTB_POZ_ZBTB41

cd18226

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

42-147

3.53e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349535 [Multi-domain] Cd Length: 114 Bit Score: 54.81 E-value: 3.53e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  42 SDKHPRQTLEVINLLR-KHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTgelaESRQTEVVIRD-IDERAMELLID 119
Cdd:cd18226   1 SLQYNKNLLKYLNDDRqKQSSFCDLVITVEGKEFSAHKVVVAVGSSYFHACLS----KNPNTDAVTLDhVSYSVFQHLLE 76

                        90       100
                ....*....|....*....|....*...
gi 87116679 120 FAYTSQITVEEGNVQTLLPAACLLQLAE 147
Cdd:cd18226  77 FLYTSEFFVYENEIPLVLEAAKFLDIID 104

BTB_POZ_ZBTB39

cd18224

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

37-152

3.55e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349533 [Multi-domain] Cd Length: 123 Bit Score: 54.84 E-value: 3.55e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  37 RMPYISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVViRDIDERAMEL 116
Cdd:cd18224   1 RIKLHSSDHPNNLLKELNKCRLSETMCDVTIVVGNRSFAAHKAVLACAAGYFQKLFLSTELDVARTYVV-DFITPANFEK 79

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 87116679 117 LIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEAC 152
Cdd:cd18224  80 VLSFIYTSELFTDLINVGVIYEVAEKLGMEDLLKAC 115

BTB_POZ_SPOP

cd18342

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

56-164

3.64e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349651 [Multi-domain] Cd Length: 125 Bit Score: 55.11 E-value: 3.64e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  56 LRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQT 135
Cdd:cd18342  16 LWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMADD 95

                        90       100
                ....*....|....*....|....*....
gi 87116679 136 LLPAACLLQLAEIQEACCEFLKRQLDPSN 164
Cdd:cd18342  96 LLAAADKYALERLKVMCEDALCSNLSVEN 124

BTB_POZ_ZBTB4

cd18195

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

45-131

3.80e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349504 [Multi-domain] Cd Length: 124 Bit Score: 54.90 E-value: 3.80e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  45 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDID---ERAMEL----- 116
Cdd:cd18195   1 HAGALLLQLNEQRLRGLFCDVTLIAGDTKFRAHRSVLAASSPYFRELLSSPLPLGAAAVAAAPGATqspERVLELpgvka 80

                        90       100
                ....*....|....*....|
gi 87116679 117 -----LIDFAYTSQITVEEG 131
Cdd:cd18195  81 gvfsdVLNFIYSSRVALPGS 100

BTB1_POZ_IBtk

cd18301

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

64-124

4.10e-09

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349610 [Multi-domain] Cd Length: 99 Bit Score: 54.22 E-value: 4.10e-09

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 87116679  64 DVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQT----EVVIRDIDERAMELLIDFAYTS 124
Cdd:cd18301  20 DVVFQVGGKTFPAHKFILASRSDYFRKLFLSSLLTSEDAvgcdVVHIEKVPPEIFEQLLQFIYTD 84

BTB_POZ_BTBD1

cd18346

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

62-164

4.12e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349655 [Multi-domain] Cd Length: 133 Bit Score: 55.06 E-value: 4.12e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  62 LCDVVLVVG----------AKKIYAHRVILSACSPYFRAMFTGELAESrQTEVVIRDIDERAMELLIDFAYTSQITVEEG 131
Cdd:cd18346  22 LSDVRFVVGkgrprgpgpgAQRIPAHRFVLAAGSAVFDAMFNGGMATT-SAEIELPDVEPAAFLALLRFLYSDEVQIGPE 100

                        90       100       110
                ....*....|....*....|....*....|...
gi 87116679 132 NVQTLLPAACLLQLAEIQEACCEFLKRQLDPSN 164
Cdd:cd18346 101 TVMTTLYTAKKYAVPALEAHCVEFLTKHLRADN 133

BTB_POZ_ZBTB16_PLZF

cd18205

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

45-156

4.27e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349514 [Multi-domain] Cd Length: 107 Bit Score: 54.27 E-value: 4.27e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  45 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFtgelaeSRQTEVVIRD-IDERAMELLIDFAYT 123
Cdd:cd18205   1 HPTGLLHKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILF------HRNSQHYTLDfLSPKTFQQILEYAYT 74

                        90       100       110
                ....*....|....*....|....*....|...
gi 87116679 124 SQITVEEGNVQTLLPAACLLQLAEIQEACCEFL 156
Cdd:cd18205  75 ATLQAKVEDLDDLLYAAEILEIEYLEEQCLKIL 107

BTB_POZ_BTBD11

cd18351

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

39-166

8.76e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349660 [Multi-domain] Cd Length: 131 Bit Score: 54.21 E-value: 8.76e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  39 PYISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAeSRQTEVVIRDIDERAMELLI 118
Cdd:cd18351   1 PKLTEIKRKQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSNKPS-AENTCIEISYVKYHIFQLVM 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 87116679 119 DFAY---TSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCL 166
Cdd:cd18351  80 QYLYcggTESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTENCV 130

BTB_POZ_ZBTB29_HIC1

cd18333

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

45-158

9.18e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349642 [Multi-domain] Cd Length: 121 Bit Score: 53.75 E-value: 9.18e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  45 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIderaMELLIDFAYTS 124
Cdd:cd18333   4 HSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSLVVHDNLINLDHEMVSPGI----FRLILDYIYTG 79

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 87116679 125 QIT-VEEGNVQTL---LPAACLLQLAEIQEACCEFLKR 158
Cdd:cd18333  80 RLSeGDPGSEQNLgavLAAASYLQIPDLVALCKKKLKR 117

PRK14131

N-acetylneuraminate epimerase;

431-556

9.87e-09

N-acetylneuraminate epimerase;

Pssm-ID: 237617 [Multi-domain] Cd Length: 376 Bit Score: 57.72 E-value: 9.87e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  431 KENKWTRVASM-STRRLGVAVAVLGGFLYAVGGS----DGTSP--LNTVERYNPQENRWH---TIAPMGTrRKHLGCAVY 500
Cdd:PRK14131  60 PSKGWTKIAAFpGGPREQAVAAFIDGKLYVFGGIgktnSEGSPqvFDDVYKYDPKTNSWQkldTRSPVGL-AGHVAVSLH 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  501 QDMIYAVGGRD---------DTTEL---SSAER----------------------YNPRTNQWSPVVAMT-SRRSGVGLA 545
Cdd:PRK14131 139 NGKAYITGGVNknifdgyfeDLAAAgkdKTPKDkindayfdkkpedyffnkevlsYDPSTNQWKNAGESPfLGTAGSAVV 218

                        170
                 ....*....|.
gi 87116679  546 VVNGQLMAVGG 556
Cdd:PRK14131 219 IKGNKLWLING 229

BTB_POZ_ZBTB34

cd18220

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

50-157

1.08e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349529 [Multi-domain] Cd Length: 120 Bit Score: 53.49 E-value: 1.08e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  50 LEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVirdIDERAMELLIDFAYTSQITVE 129
Cdd:cd18220  13 LSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGLSISVI---KNPNVFEQLLSFCYTGRMSLQ 89

                        90       100
                ....*....|....*....|....*...
gi 87116679 130 EGNVQTLLPAACLLQLAEIQEACCEFLK 157
Cdd:cd18220  90 LKDVVSFLTAASFLQMQCVIDKCTQILE 117

BTB_POZ_CP190-like

cd18311

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

50-144

1.13e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349620 [Multi-domain] Cd Length: 110 Bit Score: 53.36 E-value: 1.13e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  50 LEVINLLRKHRELCDVVL-VVGAKKIYAHRVILSACSPYFrAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITV 128
Cdd:cd18311   2 LQRLQNLFNKTEYCDLTLqFRDNEQLKVHRLVLSACTDYF-NVLEQTCEIVDDTLIMPNELQADAVVPVINFMYTGQLEF 80

                        90
                ....*....|....*.
gi 87116679 129 EEGNVQTLLPAACLLQ 144
Cdd:cd18311  81 EEKSYGKLLRTAKELN 96

BTB_POZ_ZBTB1

cd18192

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

46-154

1.17e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349501 [Multi-domain] Cd Length: 114 Bit Score: 53.29 E-value: 1.17e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  46 PRQTLEVINLLRKHRE---LCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAY 122
Cdd:cd18192   2 PSHSSYVLQQLNNQREwgfLCDCCIAIDDIYFQAHKAVLAACSSYFRMMFINHQHTTAQLNLSNMKISAECFDLILQFMY 81

                        90       100       110
                ....*....|....*....|....*....|..
gi 87116679 123 TSQITVEEGNVQTLLPAACLLQLAEIQEaCCE 154
Cdd:cd18192  82 LGKIMTAPSDFEQLKVAMNYLQLYYIPE-CLE 112

BTB2_POZ_ABTB1_BPOZ1

cd18296

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

51-161

1.93e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349605 [Multi-domain] Cd Length: 121 Bit Score: 52.68 E-value: 1.93e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  51 EVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQT-----EVVIRDIDERAMELLIDFAYT-- 123
Cdd:cd18296   6 ELPFPPEQELSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEENngsipVVTLHDVSPEVFAIVLYYIYTdd 85

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 87116679 124 SQITVEegNVQTLLPAACLLQLAEIQEACCEFLKRQLD 161
Cdd:cd18296  86 TDLPPE--NAYDVLYVADMYLLPGLKRLCGTVLAQSLD 121

BTB_POZ_ZBTB22_BING1

cd18210

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

50-156

2.15e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349519 [Multi-domain] Cd Length: 112 Bit Score: 52.54 E-value: 2.15e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  50 LEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRamftGELAESRQTEVVIRDI-DERAMELLIDFAYTSQITV 128
Cdd:cd18210   9 LESLNQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPYFH----DQVLLKNMSSISLPGVmDPGAFESVLASAYTGKLTM 84

                        90       100
                ....*....|....*....|....*...
gi 87116679 129 EEGNVQTLLPAACLLQLAEIQEACCEFL 156
Cdd:cd18210  85 LADEIVNYLTVGSVLQMWHIVDKCTELL 112

BTB_POZ_ZBTB32_FAZF_TZFP

cd18218

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

45-157

3.20e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349527 [Multi-domain] Cd Length: 110 Bit Score: 51.86 E-value: 3.20e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  45 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTgelAESRQTEVVIRDIDERAMELLIDFAYTS 124
Cdd:cd18218   1 HSDRLLHLAARLRPAGALCDTLITVGSQEFPAHSLVLAGASQQLGRQLT---NPNPGQWCLGEGISPSTFKQLLDFVYGE 77

                        90       100       110
                ....*....|....*....|....*....|...
gi 87116679 125 QITVEEGNVQTLLPAACLLQLAEIQEACCEFLK 157
Cdd:cd18218  78 SVEVQPGELRPLLEAARALEVESLEEACWRALG 110

BTB_POZ_ZBTB35_ZNF131

cd18221

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

45-151

3.46e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349530 [Multi-domain] Cd Length: 113 Bit Score: 51.93 E-value: 3.46e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  45 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRqteVVIRDIDERAMELLIDFAYTS 124
Cdd:cd18221   1 HYKVMLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQDFTQEPL---VEIEGVSNMAFRHLIEFTYTA 77

                        90       100
                ....*....|....*....|....*...
gi 87116679 125 QITVE-EGNVQTLLPAACLLQLAEIQEA 151
Cdd:cd18221  78 KLMVQgEEEANDVWKAAEYLQMQEAIKA 105

BTB_POZ_ABTB2_BPOZ2

cd18350

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

59-152

4.12e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349659 [Multi-domain] Cd Length: 134 Bit Score: 52.16 E-value: 4.12e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  59 HRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTE--VVIRDIDERAMELLIDFAY---TSQITVEEGNV 133
Cdd:cd18350  21 NKEMSDVTFLVEGKLFYAHKVLLVTASNRFKSLLTNKSEQESQGSktIEISDIKYHIFQMLMQYLYyggTESMEIPIADV 100

                        90
                ....*....|....*....
gi 87116679 134 QTLLPAACLLQLAEIQEAC 152
Cdd:cd18350 101 LELLSAASLFQLDALQRHC 119

BTB_POZ_ARMC5

cd18191

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

64-156

5.98e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in armadillo repeat-containing protein 5 (ARMC5); ARMC5 plays a role in steroidogenesis, and modulates the expression and cortisol production of steroidogenic enzymes. It negatively regulates adrenal cells survival. It contains armadillo (ARM) repeats and a BTB domain, which is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349500 [Multi-domain] Cd Length: 100 Bit Score: 50.97 E-value: 5.98e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  64 DVVLVV-GAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAY--TSQITVEEGNVQTLLPAA 140
Cdd:cd18191   3 DLRFLLdGGTQLPASRAALTGASEVFRAMLEGGFAEAQQDLVPLRQVPSGAFLPVLHYLHgcRGCDANEDDEKSDQSPEG 82

                        90
                ....*....|....*...
gi 87116679 141 CLLQ--LAEIQEACCEFL 156
Cdd:cd18191  83 DLMKssLGQTLEVAGRFL 100

BTB_POZ_ZBTB20_DPZF

cd18208

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

50-158

1.20e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349517 [Multi-domain] Cd Length: 117 Bit Score: 50.45 E-value: 1.20e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  50 LEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVirdiDERAMELLIDFAYTSQITVE 129
Cdd:cd18208  13 LETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVV----SVQSVQKLIDFMYSGVLRVS 88

                        90       100
                ....*....|....*....|....*....
gi 87116679 130 EGNVQTLLPAACLLQLAEIQEACCEFLKR 158
Cdd:cd18208  89 QSEALQILTAASILQIKTVIDECTRIVSQ 117

BTB_POZ_BTBD14A_NAC2

cd18289

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

52-162

1.33e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349598 [Multi-domain] Cd Length: 131 Bit Score: 50.80 E-value: 1.33e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  52 VINLLRKHREL---CDVVLVVGAKKIYAHRVILSACSPYFRAMFTGelaESRQTEVVIRDIDERAMELLIDFAYTSQITV 128
Cdd:cd18289  16 VLGCLNEQRLMglyCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSG---NSKSAFELPATVPPACFQQILSFCYTGKLTM 92

                        90       100       110
                ....*....|....*....|....*....|....
gi 87116679 129 EEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDP 162
Cdd:cd18289  93 AASEQLVVMYTAGFLQIQHIVERGTDLMFKVSSP 126

Kelch_6

Kelch motif;

445-492

1.45e-07

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 48.10 E-value: 1.45e-07

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 87116679   445 RLGVAVAVLGGFLYAVGG-SDGTSPLNTVERYNPQENRWHTIAPMGTRR 492
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGyTNASPALNKLEVYNPLTKSWEELPPLPTPR 50

BTB_POZ_RCBTB1_2

cd18298

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

64-158

1.52e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349607 [Multi-domain] Cd Length: 108 Bit Score: 49.95 E-value: 1.52e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  64 DVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLL 143
Cdd:cd18298  14 DLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQYSYPVYYAFLRYLYTDQVDLPPEDAIGLLDLANSY 93

                        90
                ....*....|....*
gi 87116679 144 QLAEIQEACCEFLKR 158
Cdd:cd18298  94 CEERLKKLCEDIIKQ 108

BTB_POZ_ZBTB9

cd18200

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

50-157

1.62e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349509 [Multi-domain] Cd Length: 111 Bit Score: 49.85 E-value: 1.62e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  50 LEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFtgeLAESRQTEVVIRDIDERAMELLIDFAYTSQITVE 129
Cdd:cd18200   6 LETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYFHDKL---LLNDTNCLVLPSVIEAAAFENLLQLIYSGRLTLC 82

                        90       100
                ....*....|....*....|....*...
gi 87116679 130 EGNVQTLLPAACLLQLAEIQEACCEFLK 157
Cdd:cd18200  83 MDALPSHLLVASGLQMWQVVDRCSELLK 110

BTB_POZ_ZBTB45

cd18229

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

47-158

1.80e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349538 [Multi-domain] Cd Length: 112 Bit Score: 49.86 E-value: 1.80e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  47 RQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVirdiDERAMELLIDFAYTSQI 126
Cdd:cd18229   3 KSLLETLNAQRLGGHFCDVTVRIHDASLRAHRCVLAAGSPFFHDKLLLGHSEIEVPPVV----PAQTVRQLVEFMYSGSL 78

                        90       100       110
                ....*....|....*....|....*....|..
gi 87116679 127 TVEEGNVQTLLPAACLLQLAEIQEACCEFLKR 158
Cdd:cd18229  79 VVAQSEALQILTAASILQIKTVIDECTQIISQ 110

BTB_POZ_ZBTB38_CIBZ

cd18223

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

45-140

2.14e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349532 [Multi-domain] Cd Length: 114 Bit Score: 49.79 E-value: 2.14e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  45 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTS 124
Cdd:cd18223   1 HSDTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAFSSQEIWISSHVLELPDLKAEVFAEILNFIYSS 80

                        90
                ....*....|....*.
gi 87116679 125 QITVEEGNVQTLLPAA 140
Cdd:cd18223  81 KVVVKRQETVTDLVAA 96

PLN02193

nitrile-specifier protein

333-509

2.39e-07

nitrile-specifier protein

Pssm-ID: 177844 [Multi-domain] Cd Length: 470 Bit Score: 53.42 E-value: 2.39e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  333 YDPQTNEWRM---VASMSKRRC-GVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWS--SDVAPTSTCRTSVGVAVL 406
Cdd:PLN02193 198 FDLETRTWSIspaTGDVPHLSClGVRMVSIGSTLYVFGGRDASRQYNGFYSFDTTTNEWKllTPVEEGPTPRSFHSMAAD 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  407 GGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMS---TRRLGVAVAVLGGFLYAVGGSDGTSpLNTVERYNPQENRWH 483
Cdd:PLN02193 278 EENVYVFGGVSATARLKTLDSYNIVDKKWFHCSTPGdsfSIRGGAGLEVVQGKVWVVYGFNGCE-VDDVHYYDPVQDKWT 356

                        170       180
                 ....*....|....*....|....*....
gi 87116679  484 TIAPMGTR---RKHLGCAVYQDMIYAVGG 509
Cdd:PLN02193 357 QVETFGVRpseRSVFASAAVGKHIVIFGG 385

BACK_BTBD17

cd18493

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...

137-234

2.69e-07

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.

Pssm-ID: 350568 Cd Length: 74 Bit Score: 47.96 E-value: 2.69e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679 137 LPAACLLQLAEIQEACCEFLKRqldpsnclgirafadthscrellriadkftqhNFQEVMESEEFMLLPANQLIDIISSD 216
Cdd:cd18493   9 LQYAKMCGHKELAEACLEFIAW--------------------------------NFEKVLKSPDWLNLDLDLLVSLLQSS 56

                        90
                ....*....|....*...
gi 87116679 217 ELNVRSEEQVFNAVMAWV 234
Cdd:cd18493  57 DLVVEDEYTLFQAVEKWL 74

BTB1_POZ_ABTB1_BPOZ1

cd18295

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

64-153

2.81e-07

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349604 [Multi-domain] Cd Length: 119 Bit Score: 49.56 E-value: 2.81e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  64 DVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRqtEVVIRD--IDERAMELLIDFAYTSQITVEEGNVQTLLPAA- 140
Cdd:cd18295  21 DVTFNVHGESFPAHRCILSARSPYFAEMFETKWKDKR--EINLKHplVNPDAFRALLQYLYTGRLEIHVDDVEDCKRLAk 98

                        90
                ....*....|....*
gi 87116679 141 -C-LLQLAEIQEACC 153
Cdd:cd18295  99 qCrLEELIEELEAKC 113

BACK_KLHL9_13

cd18449

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...

164-255

2.99e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.

Pssm-ID: 350524 [Multi-domain] Cd Length: 95 Bit Score: 48.57 E-value: 2.99e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679 164 NCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSiQERRP 243
Cdd:cd18449   5 NCVEIGRIANTYHLTEVDKYVNDFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHE-DDRMQ 83

                        90
                ....*....|..
gi 87116679 244 QLPQVLQHVRLP 255
Cdd:cd18449  84 FAAKLMENIRFP 95

BACK_KBTBD4

cd18481

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

164-241

4.01e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also termed BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates.

Pssm-ID: 350556 Cd Length: 88 Bit Score: 47.96 E-value: 4.01e-07

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 87116679 164 NCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSdelNVRSEEQVFNAVMAWVKYSIQER 241
Cdd:cd18481   5 NCLQVMWLADQHSDQELYTAAKHCAKTHLSQLHQTEEFLNLPLRLLTDIIKD---GVPCSQNPTAAIEAWINHNKEER 79

BTB_POZ_ZBTB40

cd18225

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

47-152

4.65e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349534 [Multi-domain] Cd Length: 116 Bit Score: 48.67 E-value: 4.65e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  47 RQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDiderAMELLIDFAYTSQI 126
Cdd:cd18225   8 RQLLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLLDSTDTISIDASVVSPE----EFALLLEMVYTGKL 83

                        90       100
                ....*....|....*....|....*.
gi 87116679 127 TVEEGNVQTLLPAACLLQLAEIQEAC 152
Cdd:cd18225  84 PPGKHNFTKIISVADSLQMFDVAVSC 109

BTB_POZ_BTBD3

cd18348

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

62-164

6.32e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349657 [Multi-domain] Cd Length: 131 Bit Score: 48.86 E-value: 6.32e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  62 LCDVVLVVG----AKKIYAHRVILSACSPYFRAMFTGELAESRQtEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLL 137
Cdd:cd18348  21 MADIHFVVGppggTQRLPGHKYVLAVGSSVFHAMFYGELAEDKD-EIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATL 99

                        90       100
                ....*....|....*....|....*..
gi 87116679 138 PAACLLQLAEIQEACCEFLKRQLDPSN 164
Cdd:cd18348 100 YAAKKYIVPHLARACVNFLETSLSAKN 126

BTB_POZ_ETO1-like

cd18190

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

64-141

1.04e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349499 [Multi-domain] Cd Length: 83 Bit Score: 46.74 E-value: 1.04e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  64 DVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRD--IDERAMELLIDFAYTSQ-ITVEEGNVQTLLPAA 140
Cdd:cd18190   1 DLVFCVGGEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFEEngISIEAMRAVIDFSVTGRlDLFSVENVHEVLELA 80


                .
gi 87116679 141 C 141
Cdd:cd18190  81 S 81

BTB2_POZ_LZTR1

cd18309

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

60-164

1.22e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349618 [Multi-domain] Cd Length: 126 Bit Score: 47.77 E-value: 1.22e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  60 RELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDI--DERAMELLIDFAYTSQITVEEGNVQTLL 137
Cdd:cd18309  18 GDFCDITLLLDGHPIPAHKAILAARCSYFEAMFRSFMPEDNTVNISIGEMvpSRQAFDSLLRYIYYGDVTMPPEDSLYLF 97

                        90       100
                ....*....|....*....|....*....
gi 87116679 138 PAACLLQLA--EIQEACCEFLKRQLDPSN 164
Cdd:cd18309  98 SAPYFYGFTnnRLQAYCKQNLEMNVSFEN 126

BACK_KLHL22

cd18461

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a ...

160-257

1.75e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of Polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.

Pssm-ID: 350536 Cd Length: 104 Bit Score: 46.68 E-value: 1.75e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679 160 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQ 239
Cdd:cd18461   1 VDEENILDVYKLADLFHLTHLSEQLDSYILKNFPTFSRTETYRQLPLEKVYSLLSSNRLEVDSENEVYEGALLYHYTPEQ 80

                        90       100
                ....*....|....*....|...
gi 87116679 240 ERRPQL-----PQVLQHVRLPLL 257
Cdd:cd18461  81 VEKDQVslqepPKLLEAVRFPLM 103

BTB2_POZ_IBtk

cd18302

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

58-137

1.90e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349611 [Multi-domain] Cd Length: 113 Bit Score: 46.97 E-value: 1.90e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  58 KHRELCDVVLV-VGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQI-TVEEGNVQT 135
Cdd:cd18302   1 KHSDLYDVTIVsEDGKEFPCHKCVLVARLEYFHSMLSSSWIEASSCSALTMPIPSDILEIILDYLYTDEAsAVKESQNVE 80


                ..
gi 87116679 136 LL 137
Cdd:cd18302  81 FL 82

Kelch_6

Kelch motif;

397-445

1.95e-06

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 45.02 E-value: 1.95e-06

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 87116679   397 CRTSVGVAVLGGFLYAVGGQ-DGVSCLNIVERYDPKENKWTRVASMSTRR 445
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLPTPR 50

BTB_POZ_ZBTB33_KAISO

cd18219

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

44-126

2.26e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349528 [Multi-domain] Cd Length: 106 Bit Score: 46.36 E-value: 2.26e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  44 KHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFT--GELAEsrqtevvIRDIDERAMELLIDFA 121
Cdd:cd18219   3 QYSGSLLKSLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQLFSvaGQVVE-------LNFIRADIFAEILNYI 75


                ....*
gi 87116679 122 YTSQI 126
Cdd:cd18219  76 YSSKI 80

BACK_BTBD7

cd18489

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7); ...

182-245

6.56e-06

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains and a BACK domain.

Pssm-ID: 350564 Cd Length: 98 Bit Score: 44.99 E-value: 6.56e-06

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 87116679 182 RIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVrSEEQVFNAVMAWVKYS----IQERRPQL 245
Cdd:cd18489  24 RQALHFLREEFSQIAQSPVLFELTKEYLIEALQSDFLQA-SELDILKAVLKWGEHQlikrMEEREPNL 90

BTB2_POZ_RHOBTB1

cd18358

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

64-161

7.42e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349667 [Multi-domain] Cd Length: 126 Bit Score: 45.72 E-value: 7.42e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  64 DVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQIT-VEEGNVQTLLPAA-- 140
Cdd:cd18358  22 DVTFKLDDGTINAHKPLLICSCEWMAAMFGGSFIESANSEVVLPNISKVSMQAVLDYLYTKQLSpTADLDPLELIALAnr 101

                        90       100
                ....*....|....*....|....
gi 87116679 141 -CLLQLAEI--QEACCEFLKRQLD 161
Cdd:cd18358 102 fCLPHLVALteQHAVQELTKASKS 125

PRK14131

N-acetylneuraminate epimerase;

451-574

1.10e-05

N-acetylneuraminate epimerase;

Pssm-ID: 237617 [Multi-domain] Cd Length: 376 Bit Score: 48.09 E-value: 1.10e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  451 AVLGGFLYaVG-GSDGTS--PLNTveryNPQENRWHTIAPM-GTRRKHLGCAVYQDMIYAVGGRDDTTE------LSSAE 520
Cdd:PRK14131  35 AIDNNTVY-VGlGSAGTSwyKLDL----NAPSKGWTKIAAFpGGPREQAVAAFIDGKLYVFGGIGKTNSegspqvFDDVY 109

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 87116679  521 RYNPRTNQWSPVvaMTsrRSGVGLAVV------NGQLMAVGG-----FDGttYLKTIEVFDPDAN 574
Cdd:PRK14131 110 KYDPKTNSWQKL--DT--RSPVGLAGHvavslhNGKAYITGGvnkniFDG--YFEDLAAAGKDKT 168

Kelch_6

Kelch motif;

492-539

1.53e-05

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 42.32 E-value: 1.53e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 87116679   492 RKHLGCAVYQDMIYAVGGRDDTTELSSA-ERYNPRTNQWSPVVAMTSRR 539
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNASPALNKlEVYNPLTKSWEELPPLPTPR 50

PLN02153

epithiospecifier protein

398-576

1.67e-05

epithiospecifier protein

Pssm-ID: 177814 [Multi-domain] Cd Length: 341 Bit Score: 47.29 E-value: 1.67e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  398 RTSVGVAVLGGFLYAVGGQ--DGVSCLNIVERYDPKENKWT------RVASMSTrrLGVAVAVLGGFLYAVGGSDGTSPL 469
Cdd:PLN02153  23 RCSHGIAVVGDKLYSFGGElkPNEHIDKDLYVFDFNTHTWSiapangDVPRISC--LGVRMVAVGTKLYIFGGRDEKREF 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  470 NTVERYNPQENRWHTIAPMGTR-----RKHLGCAVYQDMIYAVGG------RDDTTELSSAERYNPRTNQWSPVV---AM 535
Cdd:PLN02153 101 SDFYSYDTVKNEWTFLTKLDEEggpeaRTFHSMASDENHVYVFGGvskgglMKTPERFRTIEAYNIADGKWVQLPdpgEN 180

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 87116679  536 TSRRSGVGLAVVNGQLMAVGGFdGTTYL---------KTIEVFDPDANTW 576
Cdd:PLN02153 181 FEKRGGAGFAVVQGKIWVVYGF-ATSILpggksdyesNAVQFFDPASGKW 229

BTB2_POZ_RHOBTB2

cd18359

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

45-127

2.10e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2); RhoBTB2, also called Deleted in breast cancer 2 gene protein (DBC2) or p83, is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB2 functions as a tumor suppressor that regulates the expression of the methyltransferase METTL7A. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349668 [Multi-domain] Cd Length: 124 Bit Score: 44.22 E-value: 2.10e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  45 HPRQTLEVINLLRKHrELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTS 124
Cdd:cd18359   4 HVRRTNRVKECLAKG-TFSDVTFMLDDGTISAHKPLLISSCDWMAAMFGGPFVESSTTEVVFPYTSRSSMRAVLEYLYTG 82


                ...
gi 87116679 125 QIT 127
Cdd:cd18359  83 QFS 85

Kelch_6

Kelch motif;

539-586

4.47e-05

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 41.17 E-value: 4.47e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 87116679   539 RSGVGLAVVNGQLMAVGGF-DGTTYLKTIEVFDPDANTWRLYGGMNYRR 586
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLPTPR 50

COG5276

Uncharacterized secreted protein, contains LVIVD repeats, choice-of-anchor domain [Function ...

352-573

1.04e-04

Uncharacterized secreted protein, contains LVIVD repeats, choice-of-anchor domain [Function unknown];

Pssm-ID: 444087 [Multi-domain] Cd Length: 320 Bit Score: 44.55 E-value: 1.04e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679 352 GVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNqwSSDVAPTSTCRtsvGVAVLGGFLYAVG-GQDGVSCLNIVERYDP 430
Cdd:COG5276  22 ANDVWVSGEYAYVAGGSNGLAIVDVSDPANPVLV--GSLPTPGGTWR---DVKVSGDYLYVASeGSEGLQIFDISDPANP 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679 431 KEnkwtrVASMSTRRLGV-AVAVLGGFLYAVGGSDG-------TSPLNTVErynpqENRWHTIapmGTRRKHlGCAVYQD 502
Cdd:COG5276  97 KL-----VGRYDTGGSGAhNIAVDGNYAYVAGGSDNglvivdiSDPTNPVL-----VGRYSLP---GQAYLH-DVQVVGD 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679 503 MIYAVGGRD-----DTTELS-----SAERYNPRTNQWSPVVamtsrrsgvglaVVNGQLMAVGG-FDGTTYLKTIEVFDP 571
Cdd:COG5276 163 YAYVADWEDglvivDVSDPSnpkliGSYDYSPPGYTHTAVP------------VEDGNYAYVGDeLGGPNGLRILDVSDP 230


                ..
gi 87116679 572 DA 573
Cdd:COG5276 231 AN 232

Kelch_2

pfam07646

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

349-388

1.08e-04

Pssm-ID: 462220 [Multi-domain] Cd Length: 47 Bit Score: 40.01 E-value: 1.08e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 87116679   349 RRCGVGVSVLDDLLYAVGGHD--GSSYLNSVERYDPKTNQWS 388
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDglGDLSSSDVLVYDPETNVWT 42

BTB_POZ_Rank-5

cd18303

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

52-165

1.09e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349612 [Multi-domain] Cd Length: 120 Bit Score: 41.93 E-value: 1.09e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  52 VINLLRKHReLCDVVLVVGAKKIYAHRVILSACSPYFRAmftGELAESRQTEvvIRDIDERAMELLIDFAYTSQI--TVE 129
Cdd:cd18303   9 VASLFDKEL-YSDITIKLADKSIPAHKFVLAARSEKWSN---ENLASTNELD--LSDISYEVVLALLRWLYTDELdlTLD 82

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 87116679 130 EGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNC 165
Cdd:cd18303  83 DEFLLELMKAAKRFQLTDLVERCERALMSSVNVDNC 118

Kelch_4

pfam13418

Galactose oxidase, central domain;

349-388

1.43e-04

Galactose oxidase, central domain;

Pssm-ID: 433191 [Multi-domain] Cd Length: 49 Bit Score: 39.52 E-value: 1.43e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 87116679   349 RRCGVGVSVLDDLLYAVGGHDGS-SYLNSVERYDPKTNQWS 388
Cdd:pfam13418   2 RAYHTSTSIPDDTIYLFGGEGEDgTLLSDLWVFDLSTNEWT 42

YncE

COG3391

DNA-binding beta-propeller fold protein YncE [General function prediction only];

245-480

1.49e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 43.53 E-value: 1.49e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679 245 LPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVggwCSG 324
Cdd:COG3391  12 LLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVA---NSG 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679 325 DaiSSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVgghdgSSYLNSVERYDPKTNQwssDVAPTSTCRTSVGVA 404
Cdd:COG3391  89 S--GRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVA-----DSGNGRVSVIDTATGK---VVATIPVGAGPHGIA 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679 405 V--LGGFLYAV-GGQDGVSClnIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTS--PLNTVERYNPQE 479
Cdd:COG3391 159 VdpDGKRLYVAnSGSNTVSV--IVSVIDTATGKVVATIPVGGGPVGVAVSPDGRRLYVANRGSNTSngGSNTVSVIDLAT 236


                .
gi 87116679 480 N 480
Cdd:COG3391 237 L 237

PRK14131

N-acetylneuraminate epimerase;

404-463

1.50e-04

N-acetylneuraminate epimerase;

Pssm-ID: 237617 [Multi-domain] Cd Length: 376 Bit Score: 44.24 E-value: 1.50e-04

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 87116679  404 AVLGGFLYAVGG-----QDG-VSCLNIVERYDPKENKWTRVASMSTRRL--GVAVAVLGGFLYAVGGS 463
Cdd:PRK14131  81 AFIDGKLYVFGGigktnSEGsPQVFDDVYKYDPKTNSWQKLDTRSPVGLagHVAVSLHNGKAYITGGV 148

BACK_KLHL32_BKLHD5

cd18471

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...

160-257

1.63e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.

Pssm-ID: 350546 [Multi-domain] Cd Length: 98 Bit Score: 41.04 E-value: 1.63e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679 160 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMES--EEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYS 237
Cdd:cd18471   1 LNSFNYLDLYKLADLFNLTLLEEAVVDFLVKHLSELLKShpEEVLALPYRLLREVLKSDRLTSLSEEQIWQLAVRWLEHN 80

                        90       100
                ....*....|....*....|
gi 87116679 238 IqeRRPQLPQVLQHVRLPLL 257
Cdd:cd18471  81 C--RYQYMDELLQYVRFGLM 98

Kelch_6

Kelch motif;

350-398

1.92e-04

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 39.24 E-value: 1.92e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 87116679   350 RCGVGVSVLDDLLYAVGG-HDGSSYLNSVERYDPKTNQWSSdVAPTSTCR 398
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGyTNASPALNKLEVYNPLTKSWEE-LPPLPTPR 50

Kelch_3

pfam13415

Galactose oxidase, central domain;

407-453

2.28e-04

Galactose oxidase, central domain;

Pssm-ID: 433188 [Multi-domain] Cd Length: 49 Bit Score: 39.20 E-value: 2.28e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 87116679   407 GGFLYAVGG--QDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVL 453
Cdd:pfam13415   1 GDKLYIFGGlgFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49

Kelch_4

pfam13418

Galactose oxidase, central domain;

444-490

2.73e-04

Galactose oxidase, central domain;

Pssm-ID: 433191 [Multi-domain] Cd Length: 49 Bit Score: 38.75 E-value: 2.73e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 87116679   444 RRLGVAVAVLGGFLYAVGGSDG-TSPLNTVERYNPQENRWHTIAPMGT 490
Cdd:pfam13418   2 RAYHTSTSIPDDTIYLFGGEGEdGTLLSDLWVFDLSTNEWTRLGSLPS 49

BTB_POZ_NPY3-like

cd18312

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

61-147

3.06e-04

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349621 [Multi-domain] Cd Length: 105 Bit Score: 40.39 E-value: 3.06e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  61 ELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTgELAESRQTEVVIRDI--DERAMELLIDFAYTSQITVEEGNVQTLLP 138
Cdd:cd18312   8 EPSDITVRVGNTTFHLHKFPLCSKSGYFKRLAS-SSSESDPSEIELNDFpgGAEAFELVAKFCYGMPINLTATNVVGLRC 86


                ....*....
gi 87116679 139 AACLLQLAE 147
Cdd:cd18312  87 AAEYLEMTE 95

Kelch_3

pfam13415

Galactose oxidase, central domain;

312-358

4.54e-04

Galactose oxidase, central domain;

Pssm-ID: 433188 [Multi-domain] Cd Length: 49 Bit Score: 38.43 E-value: 4.54e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 87116679   312 GEVLFAVGGWC--SGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVL 358
Cdd:pfam13415   1 GDKLYIFGGLGfdGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49

Kelch_2

pfam07646

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

444-488

5.16e-04

Pssm-ID: 462220 [Multi-domain] Cd Length: 47 Bit Score: 38.09 E-value: 5.16e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 87116679   444 RRLGVAVAVLGGFLYAVGGSDGTSPL--NTVERYNPQENRWHTIAPM 488
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGDLssSDVLVYDPETNVWTEVPRL 47

Kelch_4

pfam13418

Galactose oxidase, central domain;

491-532

6.44e-04

Galactose oxidase, central domain;

Pssm-ID: 433191 [Multi-domain] Cd Length: 49 Bit Score: 37.98 E-value: 6.44e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 87116679   491 RRKHLGCAVYQDMIYAVGGR-DDTTELSSAERYNPRTNQWSPV 532
Cdd:pfam13418   2 RAYHTSTSIPDDTIYLFGGEgEDGTLLSDLWVFDLSTNEWTRL 44

PLN02153

epithiospecifier protein

312-462

6.76e-04

epithiospecifier protein

Pssm-ID: 177814 [Multi-domain] Cd Length: 341 Bit Score: 42.28 E-value: 6.76e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  312 GEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMS-----KRRCGVGVSVLDDLLYAVGGHDGSSYLNSVER------Y 380
Cdd:PLN02153  85 GTKLYIFGGRDEKREFSDFYSYDTVKNEWTFLTKLDeeggpEARTFHSMASDENHVYVFGGVSKGGLMKTPERfrtieaY 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  381 DPKTNQWSS--DVAPTSTCRTSVGVAVLGGFLYAV---------GGQDGVSClNIVERYDPKENKWTRVASMSTR---RL 446
Cdd:PLN02153 165 NIADGKWVQlpDPGENFEKRGGAGFAVVQGKIWVVygfatsilpGGKSDYES-NAVQFFDPASGKWTEVETTGAKpsaRS 243

                        170
                 ....*....|....*.
gi 87116679  447 GVAVAVLGGFLYAVGG 462
Cdd:PLN02153 244 VFAHAVVGKYIIIFGG 259

BACK_KLHL15

cd18454

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a ...

164-259

7.14e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for Cullin3 E3 ubiquitin-protein ligase complex that target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation.

Pssm-ID: 350529 Cd Length: 108 Bit Score: 39.49 E-value: 7.14e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679 164 NCLGIRAFADTHSC-----RELLriaDKFTQHNFQEVMESEEFM-LLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYS 237
Cdd:cd18454   5 NCAEIMRLLDDFSVniegvREKL---DSFLLENFVPLMSRPDFLsYLSFEKLMSYLDNDHLSRFPEIELYEAVQAWLRHD 81

                        90       100
                ....*....|....*....|..
gi 87116679 238 iQERRPQLPQVLQHVRLPLLSP 259
Cdd:cd18454  82 -RRRWRHTDTIIQNIRFCLMTP 102

BTB1_POZ_BTBD7

cd18283

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

64-147

7.97e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349592 [Multi-domain] Cd Length: 92 Bit Score: 38.85 E-value: 7.97e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  64 DVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIR--DIDERAMELLIDFAYTSQITVEEGNVQTLlpaAC 141
Cdd:cd18283   4 DVDLVFQGTCFPVHRAILSARCPFFRDLLSSSPGYGAEIPVDLPtaGIDVPMFSALLRYLYTGEFGSEDSRSQNL---DV 80


                ....*.
gi 87116679 142 LLQLAE 147
Cdd:cd18283  81 LIQLSE 86

PRK14131

N-acetylneuraminate epimerase;

336-462

8.10e-04

N-acetylneuraminate epimerase;

Pssm-ID: 237617 [Multi-domain] Cd Length: 376 Bit Score: 41.92 E-value: 8.10e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  336 QTNEWRMVASM-SKRRCGVGVSVLDDLLYAVGG-----HDGS-SYLNSVERYDPKTNQWSSdvAPTSTCRT---SVGVAV 405
Cdd:PRK14131  60 PSKGWTKIAAFpGGPREQAVAAFIDGKLYVFGGigktnSEGSpQVFDDVYKYDPKTNSWQK--LDTRSPVGlagHVAVSL 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  406 LGGFLYAVGG----------QDGVSC------------------------LNIVERYDPKENKWtRVASMST--RRLGVA 449
Cdd:PRK14131 138 HNGKAYITGGvnknifdgyfEDLAAAgkdktpkdkindayfdkkpedyffNKEVLSYDPSTNQW-KNAGESPflGTAGSA 216

                        170
                 ....*....|...
gi 87116679  450 VAVLGGFLYAVGG 462
Cdd:PRK14131 217 VVIKGNKLWLING 229

Kelch_3

pfam13415

Galactose oxidase, central domain;

454-499

1.10e-03

Galactose oxidase, central domain;

Pssm-ID: 433188 [Multi-domain] Cd Length: 49 Bit Score: 37.27 E-value: 1.10e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 87116679   454 GGFLYAVGGSD--GTSPLNTVERYNPQENRWHTIAPMGT-RRKHLGCAV 499
Cdd:pfam13415   1 GDKLYIFGGLGfdGQTRLNDLYVYDLDTNTWTQIGDLPPpRSGHSATYI 49

BTB2_POZ_RHOBTB3

cd18360

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

62-160

2.38e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349669 [Multi-domain] Cd Length: 110 Bit Score: 37.91 E-value: 2.38e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679  62 LCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYT-SQITVEEGNVQTLLPAA 140
Cdd:cd18360  10 LADVVFKIQGTTVPAHRAVLVARCEVMAAMFNGNYAEAKSFLVPIYGVSKDTFLSFLEYLYTdSCCPASILQAMALLICA 89

                        90       100
                ....*....|....*....|
gi 87116679 141 CLLQLAEIQEACCEFLKRQL 160
Cdd:cd18360  90 EMYQVSRLQHICELYIITQL 109

Vgb

COG4257

Streptogramin lyase [Defense mechanisms];

300-546

4.87e-03

Streptogramin lyase [Defense mechanisms];

Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 39.23 E-value: 4.87e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679 300 GPRTRPRKPircgevlfAVGG----WCSGDAISSVERYDPQTNEWRMVASMSkrrcGVGVSVLddllyAVgGHDGS---- 371
Cdd:COG4257  14 APGSGPRDV--------AVDPdgavWFTDQGGGRIGRLDPATGEFTEYPLGG----GSGPHGI-----AV-DPDGNlwft 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679 372 -SYLNSVERYDPKTNQWSSdVAPTSTCRTSVGVAVLG-GFLYaVGGQDGvsclNIVERYDPKENKWTRVASMSTrrlgva 449
Cdd:COG4257  76 dNGNNRIGRIDPKTGEITT-FALPGGGSNPHGIAFDPdGNLW-FTDQGG----NRIGRLDPATGEVTEFPLPTG------ 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679 450 vavlGGFLYAVG-GSDGT-----SPLNTVERYNPQENRWHTIAPM----GTRRkhlGCAVYQDMIYAVggrdDTTElSSA 519
Cdd:COG4257 144 ----GAGPYGIAvDPDGNlwvtdFGANAIGRIDPDTGTLTEYALPtpgaGPRG---LAVDPDGNLWVA----DTGS-GRI 211

                       250       260
                ....*....|....*....|....*..
gi 87116679 520 ERYNPRTNQWSPVVAMTSRRSGVGLAV 546
Cdd:COG4257 212 GRFDPKTGTVTEYPLPGGGARPYGVAV 238

BACK_GPRS_like

cd18507

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster serine-enriched ...

178-235

5.13e-03

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster serine-enriched protein (GPRS) and similar proteins; The family includes uncharacterized Drosophila melanogaster serine-enriched protein (GPRS) and similar proteins.

Pssm-ID: 350582 Cd Length: 80 Bit Score: 36.33 E-value: 5.13e-03

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 87116679 178 RELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVrSEEQVFNAVMAWVK 235
Cdd:cd18507  22 KTLVQKVLEFVDKHGTDVLNLPEFLLLPEHVVRLILSRDSLGA-DEMTKFQAALAWSR 78

BTB_POZ_ZBTB25_ZNF46_KUP

cd18213

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

45-123

5.31e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349522 [Multi-domain] Cd Length: 128 Bit Score: 37.57 E-value: 5.31e-03

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 87116679  45 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVirDIDERAMELLIDFAYT 123
Cdd:cd18213   4 HSLVLLQQLNMQREFGFLCDCTVAIGDVYFKAHRAVLAAFSNYFKMIFIHQSSECIKIQPT--DIQPDIFSYLLHIMYT 80

PQQ_2

pfam13360

PQQ-like domain; This domain contains several repeats of the PQQ repeat.

376-556

5.34e-03

PQQ-like domain; This domain contains several repeats of the PQQ repeat.

Pssm-ID: 433144 [Multi-domain] Cd Length: 233 Bit Score: 38.92 E-value: 5.34e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679   376 SVERYDPKTNQ--WSSDVAPTSTCrtsvGVAVLGGFLYAVGGQDGVSCLNIveryDPKENKWTRVASmstRRLGVAVAVL 453
Cdd:pfam13360   4 VVTALDAATGAelWRVDLETGLGG----GVAVDGGRLFVATGGGQLVALDA----ATGKLLWRQTLS---GEVLGAPLVA 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87116679   454 GGFLYAVGGSdgtsplNTVERYNPQENR--WH--TIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELssaeryNPRTNQ- 528
Cdd:pfam13360  73 GGRVFVVAGD------GSLIALDAADGRrlWSyqRSGEPLALRSSGSPAVVGDTVVAGFSSGKLVAL------DPATGKv 140

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 87116679   529 -WSPVVAMTSRRSGV--------GLAVVNGQLMAVGG 556
Cdd:pfam13360 141 rWEAPLAAPRGTNELerlvditgTPVVAGGRVFASAY 177

Kelch_6