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Conserved domains on  [gi|84781764|ref|NP_001033976|]
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P2X purinoceptor 7 isoform d [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P2X_receptor super family cl02993
ATP P2X receptor;
11-122 5.89e-43

ATP P2X receptor;


The actual alignment was detected with superfamily member pfam00864:

Pssm-ID: 470714  Cd Length: 362  Bit Score: 145.39  E-value: 5.89e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781764    11 LQYETNKVTRIQSTNYGTVKWVLHMIVFSY-ISFALVSDKLYQRKEPVISSVHTKVKGIAEVTenvteggVTKLGHSIFD 89
Cdd:pfam00864   1 FDYETPKVVVIRSKKVGLIYRLVQLLILGYiIGWVFVYEKGYQEKDTVVSSVTTKVKGVAVTN-------VSDYGIRVWD 73

                          90       100       110
                  ....*....|....*....|....*....|....
gi 84781764    90 TADYTFPLQG-NSFFVMTNYVKSEGQVQTLCPED 122
Cdd:pfam00864  74 VADYVIPPQGeNVFFVMTNLIVTPNQTQGTCPES 107
 
Name Accession Description Interval E-value
P2X_receptor pfam00864
ATP P2X receptor;
11-122 5.89e-43

ATP P2X receptor;


Pssm-ID: 459968  Cd Length: 362  Bit Score: 145.39  E-value: 5.89e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781764    11 LQYETNKVTRIQSTNYGTVKWVLHMIVFSY-ISFALVSDKLYQRKEPVISSVHTKVKGIAEVTenvteggVTKLGHSIFD 89
Cdd:pfam00864   1 FDYETPKVVVIRSKKVGLIYRLVQLLILGYiIGWVFVYEKGYQEKDTVVSSVTTKVKGVAVTN-------VSDYGIRVWD 73

                          90       100       110
                  ....*....|....*....|....*....|....
gi 84781764    90 TADYTFPLQG-NSFFVMTNYVKSEGQVQTLCPED 122
Cdd:pfam00864  74 VADYVIPPQGeNVFFVMTNLIVTPNQTQGTCPES 107
P2X TIGR00863
cation transporter protein; ATP-gated Cation Channel (ACC) Family (TC 1.A.7)Members of the ACC ...
 3-121 8.49e-22

cation transporter protein; ATP-gated Cation Channel (ACC) Family (TC 1.A.7)Members of the ACC family (also called P2X receptors) respond to ATP, a functional neurotransmitter released by exocytosis from many types of neurons.These channels, which function at neuron-neuron and neuron-smooth muscle junctions, may play roles in the control of blood pressure and pain sensation. They may also function in lymphocyte and plateletphysiology. They are found only in animals.ACC channels are probably hetero- or homomultimers and transport small monovalent cations (Me+). Some also transport Ca2+; a few also transport small metabolites. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273307  Cd Length: 372  Bit Score: 89.40  E-value: 8.49e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781764     3 ACCS--WNDVLQYETNKVTRIQSTNYGTVKWVLHMIVFSY-ISFALVSDKLYQRKEP-VISSVHTKVKGIAevtenVTEg 78
Cdd:TIGR00863   4 RLAAglSSFFFDYKTPKYVLVRNKKVGVIYRLVQLLILVYvIGWVFLAEKGYQESDTsPQSSVITKVKGVA-----VTQ- 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 84781764    79 gVTKLGHSIFDTADYTFPLQG-NSFFVMTNYVKSEGQVQTLCPE 121
Cdd:TIGR00863  78 -TSELGNRVWDVADYVKPPQGeNVFFVMTNFIVTPNQTQGRCPE 120
 
Name Accession Description Interval E-value
P2X_receptor pfam00864
ATP P2X receptor;
11-122 5.89e-43

ATP P2X receptor;


Pssm-ID: 459968  Cd Length: 362  Bit Score: 145.39  E-value: 5.89e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781764    11 LQYETNKVTRIQSTNYGTVKWVLHMIVFSY-ISFALVSDKLYQRKEPVISSVHTKVKGIAEVTenvteggVTKLGHSIFD 89
Cdd:pfam00864   1 FDYETPKVVVIRSKKVGLIYRLVQLLILGYiIGWVFVYEKGYQEKDTVVSSVTTKVKGVAVTN-------VSDYGIRVWD 73

                          90       100       110
                  ....*....|....*....|....*....|....
gi 84781764    90 TADYTFPLQG-NSFFVMTNYVKSEGQVQTLCPED 122
Cdd:pfam00864  74 VADYVIPPQGeNVFFVMTNLIVTPNQTQGTCPES 107
P2X TIGR00863
cation transporter protein; ATP-gated Cation Channel (ACC) Family (TC 1.A.7)Members of the ACC ...
 3-121 8.49e-22

cation transporter protein; ATP-gated Cation Channel (ACC) Family (TC 1.A.7)Members of the ACC family (also called P2X receptors) respond to ATP, a functional neurotransmitter released by exocytosis from many types of neurons.These channels, which function at neuron-neuron and neuron-smooth muscle junctions, may play roles in the control of blood pressure and pain sensation. They may also function in lymphocyte and plateletphysiology. They are found only in animals.ACC channels are probably hetero- or homomultimers and transport small monovalent cations (Me+). Some also transport Ca2+; a few also transport small metabolites. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273307  Cd Length: 372  Bit Score: 89.40  E-value: 8.49e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781764     3 ACCS--WNDVLQYETNKVTRIQSTNYGTVKWVLHMIVFSY-ISFALVSDKLYQRKEP-VISSVHTKVKGIAevtenVTEg 78
Cdd:TIGR00863   4 RLAAglSSFFFDYKTPKYVLVRNKKVGVIYRLVQLLILVYvIGWVFLAEKGYQESDTsPQSSVITKVKGVA-----VTQ- 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 84781764    79 gVTKLGHSIFDTADYTFPLQG-NSFFVMTNYVKSEGQVQTLCPE 121
Cdd:TIGR00863  78 -TSELGNRVWDVADYVKPPQGeNVFFVMTNFIVTPNQTQGRCPE 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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