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Conserved domains on  [gi|83641878|ref|NP_001032728|]
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presenilin-associated rhomboid-like protein, mitochondrial isoform 2 [Homo sapiens]

Protein Classification

rhomboid family protein( domain architecture ID 229382)

rhomboid family protein may be a membrane-bound serine protease that catalyzes regulated intramembrane proteolysis, resulting in the release of functional polypeptides from their membrane anchors

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rhomboid super family cl21536
Rhomboid family; This family contains integral membrane proteins that are related to ...
 201-300 1.93e-14

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


The actual alignment was detected with superfamily member pfam01694:

Pssm-ID: 451297  Cd Length: 147  Bit Score: 69.56  E-value: 1.93e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83641878   201 ASSVISNFVSYVgkvATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIFLPMFTFtagnALKAIIAMDTAGMILGWKFF 280
Cdd:pfam01694  52 LSGIAGSLLSYL---FSPLSTPSVGASGAIFGLLGALLVLGPRNRILLFGLIGALL----ALLLFILLNLVLGLLPGNGV 124

                          90       100
                  ....*....|....*....|
gi 83641878   281 DHAAHLGGALFGIWYVTYGH 300
Cdd:pfam01694 125 SNLAHLGGLLVGLLLGFILL 144
 
Name Accession Description Interval E-value
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 201-300 1.93e-14

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


Pssm-ID: 426384  Cd Length: 147  Bit Score: 69.56  E-value: 1.93e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83641878   201 ASSVISNFVSYVgkvATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIFLPMFTFtagnALKAIIAMDTAGMILGWKFF 280
Cdd:pfam01694  52 LSGIAGSLLSYL---FSPLSTPSVGASGAIFGLLGALLVLGPRNRILLFGLIGALL----ALLLFILLNLVLGLLPGNGV 124

                          90       100
                  ....*....|....*....|
gi 83641878   281 DHAAHLGGALFGIWYVTYGH 300
Cdd:pfam01694 125 SNLAHLGGLLVGLLLGFILL 144
GlpG COG0705
Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein ...
 201-295 2.64e-10

Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440469 [Multi-domain]  Cd Length: 189  Bit Score: 58.72  E-value: 2.64e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83641878 201 ASSVISNFVSYVgkVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIFLPM--FTFTAGnalkaIIAMDTAGMILGWK 278
Cdd:COG0705  88 LSGLGGGLLQLL--FSPGSGYPLVGASGAIFGLLGALLVLGPRRRVLLLFIPIpaLLFLLV-----WLLLGLLFGLLGGG 160

                        90
                ....*....|....*..
gi 83641878 279 FFDHAAHLGGALFGIWY 295
Cdd:COG0705 161 GIAWEAHLGGLLAGLLL 177
 
Name Accession Description Interval E-value
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 201-300 1.93e-14

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


Pssm-ID: 426384  Cd Length: 147  Bit Score: 69.56  E-value: 1.93e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83641878   201 ASSVISNFVSYVgkvATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIFLPMFTFtagnALKAIIAMDTAGMILGWKFF 280
Cdd:pfam01694  52 LSGIAGSLLSYL---FSPLSTPSVGASGAIFGLLGALLVLGPRNRILLFGLIGALL----ALLLFILLNLVLGLLPGNGV 124

                          90       100
                  ....*....|....*....|
gi 83641878   281 DHAAHLGGALFGIWYVTYGH 300
Cdd:pfam01694 125 SNLAHLGGLLVGLLLGFILL 144
GlpG COG0705
Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein ...
 201-295 2.64e-10

Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440469 [Multi-domain]  Cd Length: 189  Bit Score: 58.72  E-value: 2.64e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83641878 201 ASSVISNFVSYVgkVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIFLPM--FTFTAGnalkaIIAMDTAGMILGWK 278
Cdd:COG0705  88 LSGLGGGLLQLL--FSPGSGYPLVGASGAIFGLLGALLVLGPRRRVLLLFIPIpaLLFLLV-----WLLLGLLFGLLGGG 160

                        90
                ....*....|....*..
gi 83641878 279 FFDHAAHLGGALFGIWY 295
Cdd:COG0705 161 GIAWEAHLGGLLAGLLL 177
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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