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Conserved domains on  [gi|77020256|ref|NP_001029139|]
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adenylate kinase 2, mitochondrial isoform b [Rattus norvegicus]

Protein Classification

adenylate kinase family protein( domain architecture ID 11426204)

adenylate kinase family protein such as adenylate kinase that catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP

CATH:  3.40.50.300
EC:  2.7.4.-
Gene Ontology:  GO:0019205|GO:0005524|GO:0016310|GO:0006139
PubMed:  2841070|14568537|3023080

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 17-226 1.34e-113

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


:

Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 323.62  E-value: 1.34e-113
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256  17 RAVLLGPPGAGKGTQAPKLAENFCVCHLATGDMLRAMVASGSELGKKLKATMDAGKLVSDEMVVELIEKNLETPSCKNGF 96
Cdd:COG0563   2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDCANGF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256  97 LLDGFPRTVKQAEMLDDLMDKRKEKLDSVIEFSIQDSLLIRRITGRLIHPKSGRSYHEEFNPPKEAMKDDITGEPLIRRS 176
Cdd:COG0563  82 ILDGFPRTVAQAEALDELLAELGIKLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVCDKCGGELVQRA 161

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 77020256 177 DDNEKALKTRLEAYHTQTTPLVEYYRKRGIHCAIDASQTPDVVFASILAA 226
Cdd:COG0563 162 DDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADILAI 211
 
Name Accession Description Interval E-value
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 17-226 1.34e-113

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 323.62  E-value: 1.34e-113
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256  17 RAVLLGPPGAGKGTQAPKLAENFCVCHLATGDMLRAMVASGSELGKKLKATMDAGKLVSDEMVVELIEKNLETPSCKNGF 96
Cdd:COG0563   2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDCANGF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256  97 LLDGFPRTVKQAEMLDDLMDKRKEKLDSVIEFSIQDSLLIRRITGRLIHPKSGRSYHEEFNPPKEAMKDDITGEPLIRRS 176
Cdd:COG0563  82 ILDGFPRTVAQAEALDELLAELGIKLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVCDKCGGELVQRA 161

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 77020256 177 DDNEKALKTRLEAYHTQTTPLVEYYRKRGIHCAIDASQTPDVVFASILAA 226
Cdd:COG0563 162 DDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADILAI 211
adk PRK00279
adenylate kinase; Reviewed
 17-229 1.86e-111

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 318.25  E-value: 1.86e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256   17 RAVLLGPPGAGKGTQAPKLAENFCVCHLATGDMLRAMVASGSELGKKLKATMDAGKLVSDEMVVELIEKNLETPSCKNGF 96
Cdd:PRK00279   2 RLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDCKNGF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256   97 LLDGFPRTVKQAEMLDDLMDKRKEKLDSVIEFSIQDSLLIRRITGRLIHPKSGRSYHEEFNPPKEAMKDDITGEPLIRRS 176
Cdd:PRK00279  82 LLDGFPRTIPQAEALDEMLKELGIKLDAVIEIDVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKCDVCGEELIQRA 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 77020256  177 DDNEKALKTRLEAYHTQTTPLVEYYRKRGIHCAIDASQTPDVVFASILAAFSK 229
Cdd:PRK00279 162 DDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGTGSIDEVFADILKALGK 214
ADK pfam00406
Adenylate kinase;
20-204 1.36e-110

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 315.02  E-value: 1.36e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256    20 LLGPPGAGKGTQAPKLAENFCVCHLATGDMLRAMVASGSELGKKLKATMDAGKLVSDEMVVELIEKNLETPSCKNGFLLD 99
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDCKNGFLLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256   100 GFPRTVKQAEMLDDLMdKRKEKLDSVIEFSIQDSLLIRRITGRLIHPKSGRSYHEEFNPPKEAMKDDITGEPLIRRSDDN 179
Cdd:pfam00406  81 GFPRTVPQAEALEELL-ERGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPGKDDVTGEPLVQRSDDN 159

                         170       180
                  ....*....|....*....|....*
gi 77020256   180 EKALKTRLEAYHTQTTPLVEYYRKR 204
Cdd:pfam00406 160 EETVKKRLETYHKQTKPLIDYYKKK 184
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 17-228 7.69e-100

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 288.75  E-value: 7.69e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256    17 RAVLLGPPGAGKGTQAPKLAENFCVCHLATGDMLRAMVASGSELGKKLKATMDAGKLVSDEMVVELIEKNLET-PSCKNG 95
Cdd:TIGR01351   1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQnDDNENG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256    96 FLLDGFPRTVKQAEMLDDLMdkrKEKLDSVIEFSIQDSLLIRRITGRLIHPKSGRSYHEEFNPPKEAMKDDITGEPLIRR 175
Cdd:TIGR01351  81 FILDGFPRTLSQAEALDALL---EEPIDAVIELDVPDEELVERLSGRRICPSCGRVYHLKFNPPKVPGCDDCTGELLVQR 157

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 77020256   176 SDDNEKALKTRLEAYHTQTTPLVEYYRKRGIHCAIDASQTPDVVFASILAAFS 228
Cdd:TIGR01351 158 EDDTEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNGPIDEVWKRILEALK 210
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 17-219 6.18e-98

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 283.36  E-value: 6.18e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256  17 RAVLLGPPGAGKGTQAPKLAENFCVCHLATGDMLRAMVASGSELGKKLKATMDAGKLVSDEMVVELIEKNLETPSCKNGF 96
Cdd:cd01428   1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKKGF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256  97 LLDGFPRTVKQAEMLDDLMDKRKeKLDSVIEFSIQDSLLIRRITGRLIHPKSGRSYHEefnppkeaMKDDITGEPLIRRS 176
Cdd:cd01428  81 ILDGFPRTVDQAEALDELLDEGI-KPDKVIELDVPDEVLIERILGRRICPVSGRVYHL--------GKDDVTGEPLSQRS 151

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 77020256 177 DDNEKALKTRLEAYHTQTTPLVEYYRKRGIHCAIDASQTPDVV 219
Cdd:cd01428 152 DDNEETIKKRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
 
Name Accession Description Interval E-value
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 17-226 1.34e-113

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 323.62  E-value: 1.34e-113
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256  17 RAVLLGPPGAGKGTQAPKLAENFCVCHLATGDMLRAMVASGSELGKKLKATMDAGKLVSDEMVVELIEKNLETPSCKNGF 96
Cdd:COG0563   2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDCANGF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256  97 LLDGFPRTVKQAEMLDDLMDKRKEKLDSVIEFSIQDSLLIRRITGRLIHPKSGRSYHEEFNPPKEAMKDDITGEPLIRRS 176
Cdd:COG0563  82 ILDGFPRTVAQAEALDELLAELGIKLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVCDKCGGELVQRA 161

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 77020256 177 DDNEKALKTRLEAYHTQTTPLVEYYRKRGIHCAIDASQTPDVVFASILAA 226
Cdd:COG0563 162 DDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADILAI 211
adk PRK00279
adenylate kinase; Reviewed
 17-229 1.86e-111

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 318.25  E-value: 1.86e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256   17 RAVLLGPPGAGKGTQAPKLAENFCVCHLATGDMLRAMVASGSELGKKLKATMDAGKLVSDEMVVELIEKNLETPSCKNGF 96
Cdd:PRK00279   2 RLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDCKNGF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256   97 LLDGFPRTVKQAEMLDDLMDKRKEKLDSVIEFSIQDSLLIRRITGRLIHPKSGRSYHEEFNPPKEAMKDDITGEPLIRRS 176
Cdd:PRK00279  82 LLDGFPRTIPQAEALDEMLKELGIKLDAVIEIDVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKCDVCGEELIQRA 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 77020256  177 DDNEKALKTRLEAYHTQTTPLVEYYRKRGIHCAIDASQTPDVVFASILAAFSK 229
Cdd:PRK00279 162 DDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGTGSIDEVFADILKALGK 214
ADK pfam00406
Adenylate kinase;
20-204 1.36e-110

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 315.02  E-value: 1.36e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256    20 LLGPPGAGKGTQAPKLAENFCVCHLATGDMLRAMVASGSELGKKLKATMDAGKLVSDEMVVELIEKNLETPSCKNGFLLD 99
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDCKNGFLLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256   100 GFPRTVKQAEMLDDLMdKRKEKLDSVIEFSIQDSLLIRRITGRLIHPKSGRSYHEEFNPPKEAMKDDITGEPLIRRSDDN 179
Cdd:pfam00406  81 GFPRTVPQAEALEELL-ERGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPGKDDVTGEPLVQRSDDN 159

                         170       180
                  ....*....|....*....|....*
gi 77020256   180 EKALKTRLEAYHTQTTPLVEYYRKR 204
Cdd:pfam00406 160 EETVKKRLETYHKQTKPLIDYYKKK 184
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 17-228 7.69e-100

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 288.75  E-value: 7.69e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256    17 RAVLLGPPGAGKGTQAPKLAENFCVCHLATGDMLRAMVASGSELGKKLKATMDAGKLVSDEMVVELIEKNLET-PSCKNG 95
Cdd:TIGR01351   1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQnDDNENG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256    96 FLLDGFPRTVKQAEMLDDLMdkrKEKLDSVIEFSIQDSLLIRRITGRLIHPKSGRSYHEEFNPPKEAMKDDITGEPLIRR 175
Cdd:TIGR01351  81 FILDGFPRTLSQAEALDALL---EEPIDAVIELDVPDEELVERLSGRRICPSCGRVYHLKFNPPKVPGCDDCTGELLVQR 157

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 77020256   176 SDDNEKALKTRLEAYHTQTTPLVEYYRKRGIHCAIDASQTPDVVFASILAAFS 228
Cdd:TIGR01351 158 EDDTEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNGPIDEVWKRILEALK 210
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 17-219 6.18e-98

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 283.36  E-value: 6.18e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256  17 RAVLLGPPGAGKGTQAPKLAENFCVCHLATGDMLRAMVASGSELGKKLKATMDAGKLVSDEMVVELIEKNLETPSCKNGF 96
Cdd:cd01428   1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKKGF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256  97 LLDGFPRTVKQAEMLDDLMDKRKeKLDSVIEFSIQDSLLIRRITGRLIHPKSGRSYHEefnppkeaMKDDITGEPLIRRS 176
Cdd:cd01428  81 ILDGFPRTVDQAEALDELLDEGI-KPDKVIELDVPDEVLIERILGRRICPVSGRVYHL--------GKDDVTGEPLSQRS 151

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 77020256 177 DDNEKALKTRLEAYHTQTTPLVEYYRKRGIHCAIDASQTPDVV 219
Cdd:cd01428 152 DDNEETIKKRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
PLN02674 PLN02674
adenylate kinase
 17-228 2.17e-91

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 268.68  E-value: 2.17e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256   17 RAVLLGPPGAGKGTQAPKLAENFCVCHLATGDMLRAMVASGSELGKKLKATMDAGKLVSDEMVVELIEKNLETPSCKNGF 96
Cdd:PLN02674  33 RLILIGPPGSGKGTQSPIIKDEYCLCHLATGDMLRAAVAAKTPLGIKAKEAMDKGELVSDDLVVGIIDEAMKKPSCQKGF 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256   97 LLDGFPRTVKQAEMLDDLMDKRKEKLDSVIEFSIQDSLLIRRITGRLIHPKSGRSYHEEFNPPKEAMKDDITGEPLIRRS 176
Cdd:PLN02674 113 ILDGFPRTVVQAQKLDEMLAKQGAKIDKVLNFAIDDAILEERITGRWIHPSSGRTYHTKFAPPKVPGVDDVTGEPLIQRK 192

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 77020256  177 DDNEKALKTRLEAYHTQTTPLVEYYRKRGIHCAIDASQTPDVVFASILAAFS 228
Cdd:PLN02674 193 DDTAAVLKSRLEAFHKQTEPVIDYYAKKGVVANLHAEKPPKEVTAEVQKALS 244
PRK14532 PRK14532
adenylate kinase; Provisional
 19-230 2.71e-63

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 195.43  E-value: 2.71e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256   19 VLLGPPGAGKGTQAPKLAENFCVCHLATGDMLRAMVASGSELGKKLKATMDAGKLVSDEMVVELIEKNLETPSCKNGFLL 98
Cdd:PRK14532   4 ILFGPPAAGKGTQAKRLVEERGMVQLSTGDMLRAAIASGSELGQRVKGIMDRGELVSDEIVIALIEERLPEAEAAGGAIF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256   99 DGFPRTVKQAEMLDDLMDKRKEKLDSVIEFSIQDSLLIRRITGRlihpksgrsYHEEfnppkeamkdditgepliRRSDD 178
Cdd:PRK14532  84 DGFPRTVAQAEALDKMLASRGQKIDVVIRLKVDDEALIERIVKR---------FEEQ------------------GRPDD 136

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 77020256  179 NEKALKTRLEAYHTQTTPLVEYYRKRGIHCAIDASQTPDVVFASILAAFSKA 230
Cdd:PRK14532 137 NPEVFVTRLDAYNAQTAPLLPYYAGQGKLTEVDGMGSIEAVAASIDAALEGV 188
PRK14530 PRK14530
adenylate kinase; Provisional
 17-231 4.02e-59

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 185.76  E-value: 4.02e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256   17 RAVLLGPPGAGKGTQAPKLAENFCVCHLATGDMLRA---MVAS--GSELGKKlKATMDAGKLVSDEMVVELIEKNLETps 91
Cdd:PRK14530   5 RILLLGAPGAGKGTQSSNLAEEFGVEHVTTGDALRAnkqMDISdmDTEYDTP-GEYMDAGELVPDAVVNEIVEEALSD-- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256   92 cKNGFLLDGFPRTVKQAEMLDDLMDkrkekLDSVIEFSIQDSLLIRRITGRLIHPKSGRSYHEEFNPPKEAMKDDITGEP 171
Cdd:PRK14530  82 -ADGFVLDGYPRNLEQAEYLESITD-----LDVVLYLDVSEEELVDRLTGRRVCPDCGANYHVEFNQPEEEGVCDECGGE 155

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256  172 LIRRSDDNEKALKTRLEAYHTQTTPLVEYYRKRGIHCAIDASQTPDVVFASILAAFSKAT 231
Cdd:PRK14530 156 LIQRDDDTEETVRERLDVFEENTEPVIEHYRDQGVLVEVDGEQTPDEVWADIQDAIDDAT 215
adk PRK02496
adenylate kinase; Provisional
 16-226 7.44e-56

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 176.48  E-value: 7.44e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256   16 IRAVLLGPPGAGKGTQAPKLAENFCVCHLATGDMLRAMVASGSELGKKLKATMDAGKLVSDEMVVELIEKNLETPSCKNG 95
Cdd:PRK02496   2 TRLIFLGPPGAGKGTQAVVLAEHLHIPHISTGDILRQAIKEQTPLGIKAQGYMDKGELVPDQLVLDLVQERLQQPDAANG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256   96 FLLDGFPRTVKQAEMLDDLMDKRKEKLDSVIEFSIQDSLLIRRITGRlihpksgrsyheefnppkeamkdditgepliRR 175
Cdd:PRK02496  82 WILDGFPRKVTQAAFLDELLQEIGQSGERVVNLDVPDDVVVERLLAR-------------------------------GR 130

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 77020256  176 SDDNEKALKTRLEAYHTQTTPLVEYYRKRGIHCAIDASQTPDVVFASILAA 226
Cdd:PRK02496 131 KDDTEEVIRRRLEVYREQTAPLIDYYRDRQKLLTIDGNQSVEAVTTELKAA 181
PRK14531 PRK14531
adenylate kinase; Provisional
 17-228 2.92e-51

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 164.60  E-value: 2.92e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256   17 RAVLLGPPGAGKGTQAPKLAENFCVCHLATGDMLRAMVASGSELGKKLKATMDAGKLVSDEMVVELIEKNLETPScKNGF 96
Cdd:PRK14531   4 RLLFLGPPGAGKGTQAARLCAAHGLRHLSTGDLLRSEVAAGSALGQEAEAVMNRGELVSDALVLAIVESQLKALN-SGGW 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256   97 LLDGFPRTVKQAEMLDDLMDKRKEKLDSVIEFSIQDSLLIRRITGRlihpksgrsyheefnppkeamkdditgepliRRS 176
Cdd:PRK14531  83 LLDGFPRTVAQAEALEPLLEELKQPIEAVVLLELDDAVLIERLLAR-------------------------------GRA 131

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 77020256  177 DDNEKALKTRLEAYHTQTTPLVEYYRKRGIHCAIDASQTPDVVFASILAAFS 228
Cdd:PRK14531 132 DDNEAVIRNRLEVYREKTAPLIDHYRQRGLLQSVEAQGSIEAITERIEKVLA 183
PRK13808 PRK13808
adenylate kinase; Provisional
 16-230 2.61e-50

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 166.99  E-value: 2.61e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256   16 IRAVLLGPPGAGKGTQAPKLAENFCVCHLATGDMLRAMVASGSELGKKLKATMDAGKLVSDEMVVELIEKNLETPSCKNG 95
Cdd:PRK13808   1 MRLILLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVVGIISDRIEQPDAANG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256   96 FLLDGFPRTVKQAEMLDDLMDKRKEKLDSVIEFSIQDSLLIRRITGRLIHPKSgrsyheefnppkeamkddiTGEPLirR 175
Cdd:PRK13808  81 FILDGFPRTVPQAEALDALLKDKQLKLDAVVELRVNEGALLARVETRVAEMRA-------------------RGEEV--R 139

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 77020256  176 SDDNEKALKTRLEAYHTQTTPLVEYYRKRGIHCAIDASQTPDVVFASI---LAAFSKA 230
Cdd:PRK13808 140 ADDTPEVLAKRLASYRAQTEPLVHYYSEKRKLLTVDGMMTIDEVTREIgrvLAAVGAA 197
PRK14527 PRK14527
adenylate kinase; Provisional
 19-228 8.99e-49

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 158.41  E-value: 8.99e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256   19 VLLGPPGAGKGTQAPKLAENFCVCHLATGDMLRAMVASGSELGKKLKATMDAGKLVSDEMVVELIEKNLETPSCKNgFLL 98
Cdd:PRK14527  10 IFLGPPGAGKGTQAERLAQELGLKKLSTGDILRDHVARGTELGQRAKPIMEAGDLVPDELILALIRDELAGMEPVR-VIF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256   99 DGFPRTVKQAEMLDDLMDKRKEKLDSVIEFSIQDSLLIRRITGRLihpksgrsyHEEfnppkeamkdditgepliRRSDD 178
Cdd:PRK14527  89 DGFPRTLAQAEALDRLLEELGARLLAVVLLEVPDEELIRRIVERA---------RQE------------------GRSDD 141

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 77020256  179 NEKALKTRLEAYHTQTTPLVEYYRKRGIHCAIDASQTPDVVFASILAAFS 228
Cdd:PRK14527 142 NEETVRRRQQVYREQTQPLVDYYEARGHLKRVDGLGTPDEVYARILKALG 191
PRK14528 PRK14528
adenylate kinase; Provisional
 17-224 1.16e-47

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 155.55  E-value: 1.16e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256   17 RAVLLGPPGAGKGTQAPKLAENFCVCHLATGDMLRAMVASGSELGKKLKATMDAGKLVSDEMVVELIEKNLETPSCKNGF 96
Cdd:PRK14528   3 NIIFMGPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIREADCKNGF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256   97 LLDGFPRTVKQAEMLDDLMDKRKEKLDSVIEFSIQDSLLIRRITGRLIhpKSGrsyheefnppkeamkdditgeplirRS 176
Cdd:PRK14528  83 LLDGFPRTVEQADALDALLKNEGKSIDKAINLEVPDGELLKRLLGRAE--IEG-------------------------RA 135

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 77020256  177 DDNEKALKTRLEAYHTQTTPLVEYYRKRGIHCAIDASQTPDVVFASIL 224
Cdd:PRK14528 136 DDNEATIKNRLDNYNKKTLPLLDFYAAQKKLSQVNGVGSLEEVTSLIQ 183
PLN02459 PLN02459
probable adenylate kinase
 2-205 3.33e-46

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 154.23  E-value: 3.33e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256    2 APNALAPEPEHPKGIRAVLLGPPGAGKGTQAPKLAENFCVCHLATGDMLRAMVASGSELGKKLKATMDAGKLVSDEMVVE 81
Cdd:PLN02459  16 LASACDRSLAKGRNVNWVFLGCPGVGKGTYASRLSKLLGVPHIATGDLVREEIKSSGPLGAQLKEIVNQGKLVPDEIIFS 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256   82 LIEKNLETPSCK--NGFLLDGFPRTVKQAEMLDDLMDkrkekLDSVIEFSIQDSLLIRRITGRLIHPKSGRSYH------ 153
Cdd:PLN02459  96 LLSKRLEAGEEEgeSGFILDGFPRTVRQAEILEGVTD-----IDLVVNLKLREEVLVEKCLGRRICSECGKNFNvadidl 170

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 77020256  154 -----------EEFNPPKEAMKDditgepLIRRSDDNEKALKTRLEAYHTQTTPLVEYYRKRG 205
Cdd:PLN02459 171 kgedgrpgivmPPLLPPPECASK------LITRADDTEEVVKARLRVYKEESQPVEDFYRKRG 227
PRK14526 PRK14526
adenylate kinase; Provisional
 19-229 8.50e-45

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 148.85  E-value: 8.50e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256   19 VLLGPPGAGKGTQAPKLAENFCVCHLATGDMLRAMVASGSELGKKLKATMDAGKLVSDEMVVELIEKNLETPSCKNGFLL 98
Cdd:PRK14526   4 VFLGPPGSGKGTIAKILSNELNYYHISTGDLFRENILNSTPLGKEIKQIVENGQLVPDSITIKIVEDKINTIKNNDNFIL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256   99 DGFPRTVKQAEMLDDLMDKRKekldsVIEFSIQDSLLIRRITGRLIHPKSGRSYHEEFNPPKEAMKDDITGEPLIRRSDD 178
Cdd:PRK14526  84 DGFPRNINQAKALDKFLPNIK-----IINFLIDEELLIKRLSGRRICKSCNNIFNIYTLPTKEKGICDVCKGDLYQRKDD 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 77020256  179 NEKALKTRLEAYHTQTTPLVEYYRKRGIHCAIDASQTPDVVFASILAAFSK 229
Cdd:PRK14526 159 KEESLKTRLQEYKLQTKPLIEFYSKCNRLNNIDASKDIDEVKKKLIEIISK 209
PLN02842 PLN02842
nucleotide kinase
 22-229 2.54e-42

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 149.63  E-value: 2.54e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256   22 GPPGAGKGTQAPKLAENFCVCHLATGDMLRAMVASGSELGKKLKATMDAGKLVSDEMVVELIEKNLETP-SCKNGFLLDG 100
Cdd:PLN02842   4 GAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREdAKEKGWLLDG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256  101 FPRTVKQAEMLDDLmdkrKEKLDSVIEFSIQDSLLIRRITGRLIHPKSGRSYHEEFNPPkeamKDDITGEPLIRRSDDNE 180
Cdd:PLN02842  84 YPRSFAQAQSLEKL----KIRPDIFILLDVPDEILIDRCVGRRLDPVTGKIYHIKNFPP----ESEEIKARLITRPDDTE 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 77020256  181 KALKTRLEAYHTQTTPLVEYYRKrgIHCAIDASQTPDVVFASILAAFSK 229
Cdd:PLN02842 156 EKVKARLQIYKKNAEAILSTYSD--IMVKIDGNRPKEVVFEEISSLLSQ 202
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 20-230 5.31e-42

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 141.11  E-value: 5.31e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256    20 LLGPPGAGKGTQAPKLAENFCVCHLATGDMLRAMVASGSELGKKLKATMDAGKLVSDEMVVELI-EKNLETPSCKNGFLL 98
Cdd:TIGR01360   8 IVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLkDAMVAALGTSKGFLI 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256    99 DGFPRTVKQAEMLddlmDKRKEKLDSVIEFSIQDSLLIRRITGRliHPKSGrsyheefnppkeamkdditgeplirRSDD 178
Cdd:TIGR01360  88 DGYPREVKQGEEF----ERRIGPPTLVLYFDCSEDTMVKRLLKR--AETSG-------------------------RVDD 136

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 77020256   179 NEKALKTRLEAYHTQTTPLVEYYRKRGIHCAIDASQTPDVVFASILAAFSKA 230
Cdd:TIGR01360 137 NEKTIKKRLETYYKATEPVIAYYETKGKLRKINAEGTVDDVFLQVCTAIDKL 188
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 21-228 2.59e-40

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 136.73  E-value: 2.59e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256    21 LGPPGAGKGTQAPKLAENFCVCHLATGDMLRAMVA-SGSELGKKLKATMDAGKLVSDEMVVELIEKNLETPSCKNGFLLD 99
Cdd:TIGR01359   5 LGGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIKrEGSENGSLIESYIKEGKIVPSEVTVELLKKAIQEDGSSKKFLID 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256   100 GFPRTVKQAEMLDDLMDKrKEKLDSVIEFSIQDSLLIRRITGRliHPKSGrsyheefnppkeamkdditgeplirRSDDN 179
Cdd:TIGR01359  85 GFPRNEENLEAWEKLMDN-KVNFKFVLFFDCPEETMIKRLLKR--GQTSG-------------------------RVDDN 136

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 77020256   180 EKALKTRLEAYHTQTTPLVEYYRKRGIHCAIDASQTPDVVFASILAAFS 228
Cdd:TIGR01359 137 IETLKKRFRTYNEETLPIIEHFENKGKVKEINAEGSVEEVFEDVEKIFA 185
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 16-206 3.08e-32

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 117.21  E-value: 3.08e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256   16 IRAVLLGPPGAGKGTQAPKLAENFCVCHLATGDMLRAMVASGSELGKKLKATMDAGKLVSDEMVVELIEKNLE--TPSCK 93
Cdd:PTZ00088   7 LKIVLFGAPGVGKGTFAEILSKKENLKHINMGNILREEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEIAkvTDDCF 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256   94 NGFLLDGFPRTVKQAEMLDDLmdkrkEKLDSVIEFSIQDSLLIRRITGRLIHPKSGRSYH------EEFN-----PPKEA 162
Cdd:PTZ00088  87 KGFILDGFPRNLKQCKELGKI-----TNIDLFVNIYLPRNILIKKLLGRRICNTCNRNFNiahirsDPYDmppilPPADC 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 77020256  163 MKddITGEP-LIRRSDDNEKALKTRLEAYHTQTTPLVEYYRKRGI 206
Cdd:PTZ00088 162 EG--CKGNPkLQKRSDDTEEIVAHRLNTYESTNSPIIQFFKNENC 204
PRK14529 PRK14529
adenylate kinase; Provisional
 19-203 1.54e-28

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 107.11  E-value: 1.54e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256   19 VLLGPPGAGKGTQAPKLAENFCVCHLATGDMLRAMVASGSELGKKLKATMDAGKLVSDEMVVELIEKNLETPScKNGFLL 98
Cdd:PRK14529   4 LIFGPNGSGKGTQGALVKKKYDLAHIESGAIFREHIGGGTELGKKAKEYIDRGDLVPDDITIPMILETLKQDG-KNGWLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256   99 DGFPRTVKQAEMLDDLMDKRKEKLDSVIEFSIQDSLLIRRITGRLI------HPKsgrsyheefNPPKEAMKDD-----I 167
Cdd:PRK14529  83 DGFPRNKVQAEKLWEALQKEGMKLDYVIEILLPREVAKNRIMGRRLckndnnHPN---------NIFIDAIKPDgdvcrV 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 77020256  168 TGEPLIRRSDD-NEKALKTRLEAYH---TQTTPLVEYYRK 203
Cdd:PRK14529 154 CGGELSTRADDqDEEAINKRHDIYYdteTGTLAAAYFFKD 193
PLN02200 PLN02200
adenylate kinase family protein
 20-228 3.36e-27

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 104.20  E-value: 3.36e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256   20 LLGPPGAGKGTQAPKLAENFCVCHLATGDMLRAMVASGSELGKKLKATMDAGKLVSDEMVVELIEKNLETpSCKNGFLLD 99
Cdd:PLN02200  48 VLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIASNSEHGAMILNTIKEGKIVPSEVTVKLIQKEMES-SDNNKFLID 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256  100 GFPRTVKQAEMLDDLMdkrKEKLDSVIEFSIQDSLLIRRITGRlihpKSGrsyheefnppkeamkdditgeplirRSDDN 179
Cdd:PLN02200 127 GFPRTEENRIAFERII---GAEPNVVLFFDCPEEEMVKRVLNR----NQG-------------------------RVDDN 174

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 77020256  180 EKALKTRLEAYHTQTTPLVEYYRKRGIHCAIDASQTPDVVFASILAAFS 228
Cdd:PLN02200 175 IDTIKKRLKVFNALNLPVIDYYSKKGKLYTINAVGTVDEIFEQVRPIFA 223
AAA_17 pfam13207
AAA domain;
21-152 3.00e-25

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 96.15  E-value: 3.00e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77020256    21 LGPPGAGKGTQAPKLAENFCVCHLATGDMLRAMVASGsELGKKLKAtMDAGKLVSDEMVVELIEKNLETPSCKNGFLLDG 100
Cdd:pfam13207   1 TGVPGSGKTTQLKKLAEKLGFPHISAGDLLREEAKER-GLVEDRDE-MRKLPLEPQKELQKLAAERIAEEAGEGGVIVDG 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 77020256   101 FPRTVKQAEMLDDLMDKRKEKL--DSVIEFSIQDSLLIRRitgRLIHPKSGRSY 152
Cdd:pfam13207  79 HPRIKTPAGYLPGLPVEVLRELkpDAIILLEADPEEILER---RLKDRTRGRDD 129
ADK_lid pfam05191
Adenylate kinase, active site lid; Comparisons of adenylate kinases have revealed a particular ...
 142-177 2.20e-16

Adenylate kinase, active site lid; Comparisons of adenylate kinases have revealed a particular divergence in the active site lid. In some organizms, particularly the Gram-positive bacteria, residues in the lid domain have been mutated to cysteines and these cysteine residues are responsible for the binding of a zinc ion. The bound zinc ion in the lid domain, is clearly structurally homologous to Zinc-finger domains. However, it is unclear whether the adenylate kinase lid is a novel zinc-finger DNA/RNA binding domain, or that the lid bound zinc serves a purely structural function.


Pssm-ID: 461578 [Multi-domain]  Cd Length: 36  Bit Score: 70.18  E-value: 2.20e-16
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 77020256   142 RLIHPKSGRSYHEEFNPPKEAMKDDITGEPLIRRSD 177
Cdd:pfam05191   1 RRVCPKCGRIYHVYFNPPKVEGVCDVCGGELVQRDD 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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