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Conserved domains on  [gi|75677576|ref|NP_001028732|]
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dynein axonemal assembly factor 4 isoform c [Homo sapiens]

Protein Classification

p23_DYX1C1_like and 3a0801s09 domain-containing protein( domain architecture ID 10158101)

protein containing domains p23_DYX1C1_like, PTZ00121, and 3a0801s09

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
p23_DYX1C1_like cd06469
p23_like domain found in proteins similar to dyslexia susceptibility 1 (DYX1) candidate 1 (C1) ...
 10-87 2.49e-39

p23_like domain found in proteins similar to dyslexia susceptibility 1 (DYX1) candidate 1 (C1) protein, DYX1C1. The human gene encoding this protein is a positional candidate gene for developmental dyslexia (DD), it is located on 15q21.3 by the DYX1 DD susceptibility locus (15q15-21). Independent association studies have reported conflicting results. However, association of short-term memory, which plays a role in DD, with a variant within the DYX1C1 gene has been reported. Most proteins belonging to this group contain a C-terminal tetratricopeptide repeat (TPR) protein binding region.


:

Pssm-ID: 107226  Cd Length: 78  Bit Score: 134.71  E-value: 2.49e-39
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 75677576  10 WQQTKTAVFLSLPLKGVCVRDTDVFCTENYLKVNFPPFLFEAFLYAPIDDESSKAKIGNDTIVFTLYKKEAAMWETLS 87
Cdd:cd06469   1 WSQTDEDVKISVPLKGVKTSKVDIFCSDLYLKVNFPPYLFELDLAAPIDDEKSSAKIGNGVLVFTLVKKEPGIWEALC 78
3a0801s09 super family cl36792
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 276-349 1.32e-07

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


The actual alignment was detected with superfamily member TIGR00990:

Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 53.45  E-value: 1.32e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 75677576   276 DIAELCDLKEEEKN--PEWLKDKGNKLFATENYLAAINAYNLAIRLNNKmPLLYLNRAACHLKLKNLHKAIEDSSK 349
Cdd:TIGR00990 111 DESSVANLSEEERKkyAAKLKEKGNKAYRNKDFNKAIKLYSKAIECKPD-PVYYSNRAACHNALGDWEKVVEDTTA 185
 
Name Accession Description Interval E-value
p23_DYX1C1_like cd06469
p23_like domain found in proteins similar to dyslexia susceptibility 1 (DYX1) candidate 1 (C1) ...
 10-87 2.49e-39

p23_like domain found in proteins similar to dyslexia susceptibility 1 (DYX1) candidate 1 (C1) protein, DYX1C1. The human gene encoding this protein is a positional candidate gene for developmental dyslexia (DD), it is located on 15q21.3 by the DYX1 DD susceptibility locus (15q15-21). Independent association studies have reported conflicting results. However, association of short-term memory, which plays a role in DD, with a variant within the DYX1C1 gene has been reported. Most proteins belonging to this group contain a C-terminal tetratricopeptide repeat (TPR) protein binding region.


Pssm-ID: 107226  Cd Length: 78  Bit Score: 134.71  E-value: 2.49e-39
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 75677576  10 WQQTKTAVFLSLPLKGVCVRDTDVFCTENYLKVNFPPFLFEAFLYAPIDDESSKAKIGNDTIVFTLYKKEAAMWETLS 87
Cdd:cd06469   1 WSQTDEDVKISVPLKGVKTSKVDIFCSDLYLKVNFPPYLFELDLAAPIDDEKSSAKIGNGVLVFTLVKKEPGIWEALC 78
CS pfam04969
CS domain; The CS and CHORD (pfam04968) are fused into a single polypeptide chain in metazoans ...
 8-77 2.07e-10

CS domain; The CS and CHORD (pfam04968) are fused into a single polypeptide chain in metazoans but are found in separate proteins in plants; this is thought to be indicative of an interaction between CS and CHORD. It has been suggested that the CS domain is a binding module for HSP90, implying that CS domain-containing proteins are involved in recruiting heat shock proteins to multiprotein assemblies. Two CS domains are found at the N-terminus of Ubiquitin carboxyl-terminal hydrolase 19 (USP19), these domains may play a role in the interaction of USP19 with cellular inhibitor of apoptosis 2.


Pssm-ID: 461503  Cd Length: 76  Bit Score: 56.50  E-value: 2.07e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 75677576     8 YSWQQTKTAVFLSLPLKGVCVRDTDVFC--TENYLKVNFP--PFLFEAFLYAPIDDESSKAKIGNDTIVFTLYK 77
Cdd:pfam04969   3 YDWYQTLDEVTITIPVKGAGIKKKDVKVniKPRSLKVKIKggYELIDGELFHPIDPEESSWTIEGKKVEITLKK 76
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 276-349 1.32e-07

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 53.45  E-value: 1.32e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 75677576   276 DIAELCDLKEEEKN--PEWLKDKGNKLFATENYLAAINAYNLAIRLNNKmPLLYLNRAACHLKLKNLHKAIEDSSK 349
Cdd:TIGR00990 111 DESSVANLSEEERKkyAAKLKEKGNKAYRNKDFNKAIKLYSKAIECKPD-PVYYSNRAACHNALGDWEKVVEDTTA 185
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
266-346 2.36e-06

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 47.99  E-value: 2.36e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677576 266 QAEARRAMNTDIAELCDLKEEEKNPEW---LKDKGNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHK 342
Cdd:COG4785  46 LALAAAALAAAALAAERIDRALALPDLaqlYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDA 125


                ....
gi 75677576 343 AIED 346
Cdd:COG4785 126 ALED 129
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 293-349 1.21e-03

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 40.54  E-value: 1.21e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 75677576  293 LKDKGNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSK 349
Cdd:PLN03088   5 LEDKAKEAFVDDDFALAVDLYTQAIDLDPNNAELYADRAQANIKLGNFTEAVADANK 61
TPR_11 pfam13414
TPR repeat;
297-337 1.83e-03

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 35.91  E-value: 1.83e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 75677576   297 GNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKL 337
Cdd:pfam13414   1 GDAYYEQGKYEEAIEAYKKALKLDPDNPEAYYNLGLAYYKL 41
 
Name Accession Description Interval E-value
p23_DYX1C1_like cd06469
p23_like domain found in proteins similar to dyslexia susceptibility 1 (DYX1) candidate 1 (C1) ...
 10-87 2.49e-39

p23_like domain found in proteins similar to dyslexia susceptibility 1 (DYX1) candidate 1 (C1) protein, DYX1C1. The human gene encoding this protein is a positional candidate gene for developmental dyslexia (DD), it is located on 15q21.3 by the DYX1 DD susceptibility locus (15q15-21). Independent association studies have reported conflicting results. However, association of short-term memory, which plays a role in DD, with a variant within the DYX1C1 gene has been reported. Most proteins belonging to this group contain a C-terminal tetratricopeptide repeat (TPR) protein binding region.


Pssm-ID: 107226  Cd Length: 78  Bit Score: 134.71  E-value: 2.49e-39
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 75677576  10 WQQTKTAVFLSLPLKGVCVRDTDVFCTENYLKVNFPPFLFEAFLYAPIDDESSKAKIGNDTIVFTLYKKEAAMWETLS 87
Cdd:cd06469   1 WSQTDEDVKISVPLKGVKTSKVDIFCSDLYLKVNFPPYLFELDLAAPIDDEKSSAKIGNGVLVFTLVKKEPGIWEALC 78
p23_like cd06463
Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) ...
 10-86 1.16e-15

Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including the progesterone receptor. p23 also has a passive chaperoning activity and in addition may participate in prostaglandin synthesis. Both p23 and Sba1p can regulate telomerase activity. This group includes domains similar to the C-terminal CHORD-SGT1 (CS) domain of suppressor of G2 allele of Skp1 (Sgt1). Sgt1 interacts with multiple protein complexes and has the features of a co-chaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has been shown to bind Hsp90 through its CS domain. Saccharomyces cerevisiae (Sc) Sgt1 is a subunit of both core kinetochore and SCF (Skp1-Cul1-F-box) ubiquitin ligase complexes. Sgt1 is required for pathogen resistance in plants. This group also includes the p23_like domains of human butyrate-induced transcript 1 (hB-ind1), NUD (nuclear distribution) C, Melusin, and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR). hB-ind1 plays a role in the signaling pathway mediated by the small GTPase Rac1, NUDC is needed for nuclear movement, Melusin interacts with two splice variants of beta1 integrin, and NCB5OR plays a part in maintaining viable pancreatic beta cells.


Pssm-ID: 107220  Cd Length: 84  Bit Score: 71.55  E-value: 1.16e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677576  10 WQQTKTAVFLSLPLKGVCVRDTDVFCTENYLKVNF-----PPFLFEAFLYAPIDDESSKAKIGNDTIVFTLYKKEAA-MW 83
Cdd:cd06463   1 WYQTLDEVTITIPLKDVTKKDVKVEFTPKSLTVSVkggggKEYLLEGELFGPIDPEESKWTVEDRKIEITLKKKEPGeWW 80


                ...
gi 75677576  84 ETL 86
Cdd:cd06463  81 PRL 83
CS pfam04969
CS domain; The CS and CHORD (pfam04968) are fused into a single polypeptide chain in metazoans ...
 8-77 2.07e-10

CS domain; The CS and CHORD (pfam04968) are fused into a single polypeptide chain in metazoans but are found in separate proteins in plants; this is thought to be indicative of an interaction between CS and CHORD. It has been suggested that the CS domain is a binding module for HSP90, implying that CS domain-containing proteins are involved in recruiting heat shock proteins to multiprotein assemblies. Two CS domains are found at the N-terminus of Ubiquitin carboxyl-terminal hydrolase 19 (USP19), these domains may play a role in the interaction of USP19 with cellular inhibitor of apoptosis 2.


Pssm-ID: 461503  Cd Length: 76  Bit Score: 56.50  E-value: 2.07e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 75677576     8 YSWQQTKTAVFLSLPLKGVCVRDTDVFC--TENYLKVNFP--PFLFEAFLYAPIDDESSKAKIGNDTIVFTLYK 77
Cdd:pfam04969   3 YDWYQTLDEVTITIPVKGAGIKKKDVKVniKPRSLKVKIKggYELIDGELFHPIDPEESSWTIEGKKVEITLKK 76
ACD_sHsps_p23-like cd00298
This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small ...
 10-77 2.06e-08

This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is this ACD. sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps. p23 is a cochaperone of the Hsp90 chaperoning pathway. It binds Hsp90 and participates in the folding of a number of Hsp90 clients including the progesterone receptor. p23 also has a passive chaperoning activity. p23 in addition may act as the cytosolic prostaglandin E2 synthase. Included in this family is the p23-like C-terminal CHORD-SGT1 (CS) domain of suppressor of G2 allele of Skp1 (Sgt1) and the p23-like domains of human butyrate-induced transcript 1 (hB-ind1), NUD (nuclear distribution) C, Melusin, and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR).


Pssm-ID: 107219  Cd Length: 80  Bit Score: 51.05  E-value: 2.06e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677576  10 WQQTKTAVFLSLPLKGVCVRDTDVFCTENYLKV------------NFPPFLFEAFLYAPIDDESSKAKIGNDTIVFTLYK 77
Cdd:cd00298   1 WYQTDDEVVVTVDLPGVKKEDIKVEVEDNVLTIsgkreeeeererSYGEFERSFELPEDVDPEKSKASLENGVLEITLPK 80
p23_CS_SGT1_like cd06466
p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 ...
 10-86 4.06e-08

p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has been shown to bind Hsp90 through its CS domain. Saccharomyces cerevisiae (Sc) Sgt1 is a subunit of both core kinetochore and SCF (Skp1-Cul1-F-box) ubiquitin ligase complexes. Sgt1 is required for pathogen resistance in plants. ScSgt1 is needed for the G1/S and G2/M cell-cycle transitions, and for assembly of the core kinetochore complex (CBF3) via activation of Ctf13, the F-box protein. Binding of Hsp82 (a yeast Hsp90 homologue) to ScSgt1, promotes the binding of Sgt1 to Skp1 and of Skp1 to Ctf13. Some proteins in this group have an SGT1-specific (SGS) domain at the extreme C-terminus. The ScSgt1-SGS domain binds adenylate cyclase. The hSgt1-SGS domain interacts with some S100 family proteins, and studies suggest that the interaction of hSgt1 with Hsp90 and Hsp70 may be regulated by S100A6 in a Ca2+ dependent fashion. This group also includes the p23_like domains of Melusin and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR). Melusin is a vertebrate protein which interacts with two splice variants of beta1 integrin, and NCB5OR plays a part in maintaining viable pancreatic beta cells.


Pssm-ID: 107223  Cd Length: 84  Bit Score: 50.28  E-value: 4.06e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677576  10 WQQTKTAVFLSLPLKGVCVRDTDVFCTENYLKVNFP-----PFLFEAFLYAPIDDESSKAKIGNDTIVFTLYKKEAAMWE 84
Cdd:cd06466   2 WYQTDTSVTVTIYAKNVDKEDVKVEFNEQSLSVSIIlpggsEYQLELDLFGPIDPEQSKVSVLPTKVEITLKKAEPGSWP 81


                ..
gi 75677576  85 TL 86
Cdd:cd06466  82 SL 83
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 276-349 1.32e-07

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 53.45  E-value: 1.32e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 75677576   276 DIAELCDLKEEEKN--PEWLKDKGNKLFATENYLAAINAYNLAIRLNNKmPLLYLNRAACHLKLKNLHKAIEDSSK 349
Cdd:TIGR00990 111 DESSVANLSEEERKkyAAKLKEKGNKAYRNKDFNKAIKLYSKAIECKPD-PVYYSNRAACHNALGDWEKVVEDTTA 185
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
266-346 2.36e-06

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 47.99  E-value: 2.36e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677576 266 QAEARRAMNTDIAELCDLKEEEKNPEW---LKDKGNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHK 342
Cdd:COG4785  46 LALAAAALAAAALAAERIDRALALPDLaqlYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDA 125


                ....
gi 75677576 343 AIED 346
Cdd:COG4785 126 ALED 129
p23_hB-ind1_like cd06465
p23_like domain found in human (h) butyrate-induced transcript 1 (B-ind1) and similar proteins. ...
 10-83 6.59e-05

p23_like domain found in human (h) butyrate-induced transcript 1 (B-ind1) and similar proteins. hB-ind1 participates in signaling by the small GTPase Rac1. It binds to Rac1 and enhances different Rac1 effects including activation of nuclear factor (NF) kappaB and activation of c-Jun N-terminal kinase (JNK). hB-ind1 also plays a part in the RNA replication and particle production of Hepatitis C virus (HCV) through its interaction with heat shock protein Hsp90, HCV nonstructural protein 5A (NS5A), and the immunophilin FKBP8. hB-ind1 is upregulated in the outer layer of Chinese hamster V79 cells grown as multicell spheroids, versus in the same cells grown as monolayers. This group includes the Saccharomyces cerevisiae Sba1, a co-chaperone of the Hsp90. Sba1 has been shown to be is required for telomere length maintenance, and may modulate telomerase DNA-binding activity.


Pssm-ID: 107222 [Multi-domain]  Cd Length: 108  Bit Score: 41.81  E-value: 6.59e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677576  10 WQQTKTAVFLSLPLKgvCVRDTDVFCTENYLKvnfppflFEAF-------------LYAPIDDESSKAKIGNDTIVFTLY 76
Cdd:cd06465   5 WAQRSDVVYLTIELP--DAKDPKIKLEPTSLS-------FKAKgggggkkyefdleFYKEIDPEESKYKVTGRQIEFVLR 75


                ....*..
gi 75677576  77 KKEAAMW 83
Cdd:cd06465  76 KKEAGEY 82
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 249-345 1.90e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 43.44  E-value: 1.90e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677576 249 TALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEK--------------NPEWLKDKGNKLFATENYLAAINAYN 314
Cdd:COG3914  57 AALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEalalyrralalnpdNAEALFNLGNLLLALGRLEEALAALR 136

                        90       100       110
                ....*....|....*....|....*....|.
gi 75677576 315 LAIRLNNKMPLLYLNRAACHLKLKNLHKAIE 345
Cdd:COG3914 137 RALALNPDFAEAYLNLGEALRRLGRLEEAIA 167
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
283-346 2.41e-04

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 42.21  E-value: 2.41e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 75677576 283 LKEEEKNPEWLKDKGNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIED 346
Cdd:COG4785 100 LELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIAD 163
p23_NUDC_like cd06467
p23_like domain of NUD (nuclear distribution) C and similar proteins. Aspergillus nidulas (An) ...
 8-86 4.73e-04

p23_like domain of NUD (nuclear distribution) C and similar proteins. Aspergillus nidulas (An) NUDC is needed for nuclear movement. AnNUDC is localized at the hyphal cortex, and binds NUDF at spindle pole bodies (SPBs) and in the cytoplasm at different stages in the cell cycle. At the SPBs it is part of the dynein molecular motor/NUDF complex that regulates microtubule dynamics. Mammalian(m) NUDC associates both with the dynein complex and also with an anti-inflammatory enzyme, platelet activating factor acetylhydrolase I, PAF-AH(I) complex, through binding mNUDF, the regulatory beta subunit of PAF-AH(I). mNUDC is important for cell proliferation both in normal and tumor tissues. Its expression is elevated in various cell types undergoing mitosis or stimulated to proliferate, with high expression levels observed in leukemic cells and tumors. For a leukemic cell line, human NUDC was shown to activate the thrombopoietin (TPO) receptor (Mpl) by binding to its extracellular domain, and promoting cell proliferation and differentiation. This group also includes the human broadly immunogenic tumor associated antigen, CML66, which is highly expressed in a variety of solid tumors and in leukemias. In normal tissues high expression of CML66 is limited to testis and heart.


Pssm-ID: 107224  Cd Length: 85  Bit Score: 38.68  E-value: 4.73e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677576   8 YSWQQTKTAVFLSLPLKgVCVRDTDVFC--TENYLKV--NFPPFLFEAFLYAPIDDESSKAKI-GNDTIVFTLYK-KEAA 81
Cdd:cd06467   1 YSWTQTLDEVTVTIPLP-EGTKSKDVKVeiTPKHLKVgvKGGEPLLDGELYAKVKVDESTWTLeDGKLLEITLEKrNEGE 79


                ....*
gi 75677576  82 MWETL 86
Cdd:cd06467  80 WWPSL 84
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
283-346 5.92e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 41.15  E-value: 5.92e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 75677576 283 LKEEEKNPEWLKDKGNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIED 346
Cdd:COG0457  69 LELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEA 132
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
283-346 1.00e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 40.38  E-value: 1.00e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 75677576 283 LKEEEKNPEWLKDKGNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIED 346
Cdd:COG0457  35 LELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALED 98
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 293-349 1.21e-03

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 40.54  E-value: 1.21e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 75677576  293 LKDKGNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSK 349
Cdd:PLN03088   5 LEDKAKEAFVDDDFALAVDLYTQAIDLDPNNAELYADRAQANIKLGNFTEAVADANK 61
p23_CacyBP cd06468
p23_like domain found in proteins similar to Calcyclin-Binding Protein(CacyBP) ...
 5-86 1.70e-03

p23_like domain found in proteins similar to Calcyclin-Binding Protein(CacyBP)/Siah-1-interacting protein (SIP). CacyBP/SIP interacts with S100A6 (calcyclin), with some other members of the S100 family, with tubulin, and with Siah-1 and Skp-1. The latter two are components of the ubiquitin ligase that regulates beta-catenin degradation. The beta-catenin gene is an oncogene participating in tumorigenesis in many different cancers. Overexpression of CacyBP/SIP, in part through its effect on the expression of beta-catenin, inhibits the proliferation, tumorigenicity, and invasion of gastric cancer cells. CacyBP/SIP is abundant in neurons and neuroblastoma NB2a cells. An extensive re-organization of microtubules accompanies the differentiation of NB2a cells. CacyBP/SIP may contribute to NB2a cell differentiation through binding to and increasing the oligomerization of tubulin. CacyBP/SIP is also implicated in differentiation of erythroid cells, rat neonatal cardiomyocytes, in mouse endometrial events, and in thymocyte development.


Pssm-ID: 107225  Cd Length: 92  Bit Score: 37.24  E-value: 1.70e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677576   5 VSDYSWQQTKTAVFLSLPLKGVcvrdtDVFCTENyLKVNFPPFLFEAF---------------LYAPIDDESSKAKIGND 69
Cdd:cd06468   1 ITKYAWDQSDKFVKIYITLKGV-----HQLPKEN-IQVEFTERSFELKvhdlngknyrftinrLLKKIDPEKSSFKVKTD 74

                        90
                ....*....|....*..
gi 75677576  70 TIVFTLYKKEAAMWETL 86
Cdd:cd06468  75 RIVITLAKKKEKKWESL 91
TPR_11 pfam13414
TPR repeat;
297-337 1.83e-03

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 35.91  E-value: 1.83e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 75677576   297 GNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKL 337
Cdd:pfam13414   1 GDAYYEQGKYEEAIEAYKKALKLDPDNPEAYYNLGLAYYKL 41
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 289-345 2.38e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 39.98  E-value: 2.38e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 75677576 289 NPEWLKDKGNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIE 345
Cdd:COG3914 145 FAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIA 201
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
283-350 2.86e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 38.83  E-value: 2.86e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 75677576 283 LKEEEKNPEWLKDKGNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSKE 350
Cdd:COG0457 103 LELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKL 170
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 257-345 3.23e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 39.59  E-value: 3.23e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677576 257 AEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLK 336
Cdd:COG3914  45 LLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLA 124


                ....*....
gi 75677576 337 LKNLHKAIE 345
Cdd:COG3914 125 LGRLEEALA 133
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
283-346 3.68e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 38.45  E-value: 3.68e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 75677576 283 LKEEEKNPEWLKDKGNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIED 346
Cdd:COG0457   1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALAD 64
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 283-345 4.10e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 37.29  E-value: 4.10e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 75677576 283 LKEEEKNPEWLKDKGNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIE 345
Cdd:COG4235  10 LAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEE 72
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 283-346 5.73e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 36.71  E-value: 5.73e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 75677576 283 LKEEEKNPEWLKDKGNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIED 346
Cdd:COG4783  65 LELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAA 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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